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Yansheng Du

Research Profile

Disorders

Alzheimer's Disease

Chemicals & Drugs

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Publications

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Yvonne Roettger; Inga Zerr; Michael Bacher; Richard Dodel; Yansheng Du; Jan-Philipp Bach
Immunotherapy in prion disease.
Huiying Gu; Lan Hong; Yulia N Pushkar; Gregory Robison; Xing Wei; Raul Barrea; Yansheng Du; Martin R Farlow; Wei Zheng
Increased β-amyloid deposition in Tg-SWDI transgenic mouse brain following in vivo lead exposure.
C V Fontanilla; B Johnstone; R M Pascuzzi; Xing Wei; L Zhao; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester extends survival of a mouse model of amyotrophic lateral sclerosis.

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All Publications

2013: Yvonne Roettger; Inga Zerr; Michael Bacher; Richard Dodel; Yansheng Du; Jan-Philipp Bach
Immunotherapy in prion disease.
Nature reviews. Neurology 2013;9(2):98-105.
2012: Huiying Gu; Lan Hong; Yulia N Pushkar; Gregory Robison; Xing Wei; Raul Barrea; Yansheng Du; Martin R Farlow; Wei Zheng
Increased β-amyloid deposition in Tg-SWDI transgenic mouse brain following in vivo lead exposure.
Toxicology letters 2012;213(2):211-9.
2012: C V Fontanilla; B Johnstone; R M Pascuzzi; Xing Wei; L Zhao; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester extends survival of a mouse model of amyotrophic lateral sclerosis.
Neuroscience 2012;205():185-93.
2011: C V Fontanilla; J Klotsche; Z Ma; Wolfgang H Oertel; Xing Wei; Paul Wisniowski; L Zhao; Richard Dodel; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration.
Neuroscience 2011;188():135-41.
2011: B Tan; Z Luan; Xing Wei; Y He; G Wei; B H Johnstone; Martin R Farlow; Yansheng Du
AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells.
Neuroscience 2011;181():40-7.
2011: Richard Dodel; Karthikeyan Balakrishnan; Kathy Keyvani; Oliver Deuster; Frauke Neff; Luminita-Cornelia Andrei-Selmer; Stephan Röskam; Carsten Stüer; Yousef Al-Abed; Carmen Noelker; Monika Balzer-Geldsetzer; Wolfgang Oertel; Yansheng Du; Michael Bacher
Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(15):5847-54.
2011: Huiying Gu; Xing Wei; Andrew D Monnot; Christine V Fontanilla; Mamta Behl; Martin R Farlow; Wei Zheng; Yansheng Du
Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice.
Neuroscience letters 2011;490(1):16-20.
2010: Richard Dodel; Frauke Neff; Carmen Noelker; Refik Pul; Yansheng Du; Michael Bacher; Wolfgang Oertel
Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence.
Drugs 2010;70(5):513-28.
2009: Xing Wei; L Zhao; J Zhong; H Gu; D Feng; B H Johnstone; Keith March; Martin R Farlow; Yansheng Du
Adipose stromal cells-secreted neuroprotective media against neuronal apoptosis.
Neuroscience letters 2009;462(1):76-9.
2009: Jin Zhong; Limin Zhao; Yansheng Du; Gang Wei; Wei-Guo Yao; Wei-Hua Lee
Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats.
Neurological research 2009;31(5):483-9.
2009: Yan Hou; Wanfang Shao; Rong Xiao; Kunlong Xu; Zhizhong Ma; Brian H Johnstone; Yansheng Du
Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model.
Experimental gerontology 2009;44(6-7):434-9.
2009: L Zhao; Xing Wei; Z Ma; D Feng; P Tu; B H Johnstone; Keith March; Yansheng Du
Adipose stromal cells-conditional medium protected glutamate-induced CGNs neuronal death by BDNF.
Neuroscience letters 2009;452(3):238-40.
2009: Xing Wei; Zhimei Du; Liming Zhao; Dongni Feng; Gang Wei; Yongzheng He; Jiangning Tan; Wei-Hui Lee; Harald Hampel; Richard Dodel; Brian H Johnstone; Keith March; Martin R Farlow; Yansheng Du
IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats.
Stem cells (Dayton, Ohio) 2009;27(2):478-88.
2009: Michael Bacher; Candan Depboylu; Yansheng Du; Carmen Noelker; Wolfgang H Oertel; Thomas Behr; Gjermund Henriksen; Martin Behe; Richard Dodel
Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease.
Neuroscience letters 2009;449(3):240-5.
2008: Xing Wei; Z Ma; C V Fontanilla; L Zhao; Zao C Xu; V Taggliabraci; Brian H Johnstone; Richard Dodel; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity.
Neuroscience 2008;155(4):1098-105.
2008: Frauke Neff; Xing Wei; Carmen Nölker; Michael Bacher; Yansheng Du; Richard Dodel
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.
Autoimmunity reviews 2008;7(6):501-7.
2007: Xing Wei; Xianming Chen; Christine Fontanilla; Liming Zhao; Zhong Liang; Richard Dodel; Harald Hampel; Martin R Farlow; Yansheng Du
C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line.
Life sciences 2007;80(12):1152-6.
2006: Zhizhong Ma; Xing Wei; Christine Fontanilla; Carmen Noelker; Richard Dodel; Harald Hampel; Yansheng Du
Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity.
Life sciences 2006;79(13):1307-11.
2006: Candan Depboylu; Frank Lohmüller; Yansheng Du; Matthias Riemenschneider; Alexander Kurz; Thomas Gasser; Ulrich Müller; Richard Dodel
Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.
Neuroscience letters 2006;400(3):187-90.
2005: Katharina Buerger; Stefan J Teipel; Raymond Zinkowski; Trey Sunderland; Niels Andreasen; Kaj Blennow; Michael Ewers; John DeBernardis; Yong Shen; Daniel Kerkman; Yansheng Du; Harald Hampel
Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment.
Neuroscience letters 2005;391(1-2):48-50.
2005: Jiangning Tan; Zhizhong Ma; Ling Han; Ruyu Du; Liming Zhao; Xing Wei; Dongming Hou; Brian H Johnstone; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2265-71.
2005: Suizhen Lin; Vincent S Tagliabracci; Xianming Chen; Yansheng Du
Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity.
Neuroreport 2005;16(13):1461-5.
2005: Carmen Noelker; Michael Bacher; Petra Gocke; Xing Wei; Thomas Klockgether; Yansheng Du; Richard Dodel
The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity.
Neuroscience letters 2005;383(1-2):39-43.
2005: Suizhen Lin; Xing Wei; Kelly R Bales; Aaron B C Paul; Zhizhong Ma; Guangmei Yan; Steven M Paul; Yansheng Du
Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat.
The European journal of neuroscience 2005;22(1):21-7.
2005: Yansheng Du; Xianming Chen; Xing Wei; Kelly R Bales; David T Berg; Steven M Paul; Martin R Farlow; Bryan Maloney; Yuan-Wen Ge; Debomoy K Lahiri
NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells.
Brain research. Molecular brain research 2005;136(1-2):177-88.
2005: Sylvia Brettschneider; Nils G. Morgenthaler; Stefan J Teipel; Christina Fischer-Schulz; Katharina Bürger; Richard Dodel; Yansheng Du; Hans-Jürgen Möller; Andreas Bergmann; Harald Hampel
Decreased serum amyloid beta(1-42) autoantibody levels in Alzheimer's disease, determined by a newly developed immuno-precipitation assay with radiolabeled amyloid beta(1-42) peptide.
Biological psychiatry 2005;57(7):813-6.
2005: X Wei; L Zhao; J Liu; Richard Dodel; Martin R Farlow; Yansheng Du
Minocycline prevents gentamicin-induced ototoxicity by inhibiting p38 MAP kinase phosphorylation and caspase 3 activation.
Neuroscience 2005;131(2):513-21.
2004: Xing Wei; Liming Zhao; Zhizhong Ma; David M Holtzman; Chong Yan; Richard Dodel; Harald Hampel; Wolfgang H Oertel; Martin R Farlow; Yansheng Du
Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury.
Brain : a journal of neurology 2004;127(Pt 12):2629-35.
2004: Richard Dodel; Yansheng Du; Candan Depboylu; Harald Hampel; Lutz Froelich; A Haag; U Hemmeter; S Paulsen; Stefan J Teipel; Sylvia Brettschneider; Annika Spottke; C Nölker; Hans-Jürgen Möller; X Wei; Martin R Farlow; Norbert Sommer; Wolfgang H Oertel
Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 2004;75(10):1472-4.
2004: Harald Hampel; Stefan J Teipel; T Fuchsberger; Niels Andreasen; J Wiltfang; M Otto; Yong Shen; Richard Dodel; Yansheng Du; Martin R Farlow; Hans-Jürgen Möller; Kaj Blennow; Katharina Buerger
Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment.
Molecular psychiatry 2004;9(7):705-10.
2004: Elsa Diguet; Pierre-Olivier Fernagut; Xing Wei; Yansheng Du; Richard Rouland; Christian Gross; Erwan Bezard; François Tison
Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease.
The European journal of neuroscience 2004;19(12):3266-76.
2004: J Carsten Möller; Candan Depboylu; Heike Kölsch; Frank Lohmüller; Oliver Bandmann; Petra Gocke; Yansheng Du; Sebastian Paus; Ullrich Wüllner; Thomas Gasser; Wolfgang H Oertel; Thomas Klockgether; Richard Dodel
Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease.
Neuroscience letters 2004;359(3):195-7.
2004: Candan Depboylu; Frank Lohmüller; Petra Gocke; Yansheng Du; Reinhilde Zimmer; Thomas Gasser; Thomas Klockgether; Richard Dodel
An interleukin-6 promoter variant is not associated with an increased risk for Alzheimer's disease.
Dementia and geriatric cognitive disorders 2004;17(3):170-3.
2003: Suizhen Lin; Chong Yan; Xing Wei; Steven M Paul; Yansheng Du
p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons.
Neuroscience letters 2003;353(3):209-12.
2003: Yansheng Du; Xing Wei; Richard Dodel; Norbert Sommer; Harald Hampel; Feng Gao; Zhizhong Ma; Liming Zhao; Wolfgang H Oertel; Martin R Farlow
Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity.
Brain : a journal of neurology 2003;126(Pt 9):1935-9.
2003: Candan Depboylu; Yansheng Du; Ulrich Müller; Alexander Kurz; Reinhilde Zimmer; Matthias Riemenschneider; Thomas Gasser; Wolfgang H Oertel; Thomas Klockgether; Richard Dodel; Wolfgang H Oertelf
Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease.
Neuroscience letters 2003;342(1-2):132-4.
2003: Richard Dodel; Harald Hampel; Yansheng Du
Immunotherapy for Alzheimer's disease.
Lancet neurology 2003;2(4):215-20.
2003: Suizhen Lin; Xing Wei; Yong Xu; Chong Yan; Richard Dodel; Yuqin Zhang; Junyi Liu; James Klaunig; Martin R Farlow; Yansheng Du
Minocycline blocks 6-hydroxydopamine-induced neurotoxicity and free radical production in rat cerebellar granule neurons.
Life sciences 2003;72(14):1635-41.
2002: Debomoy K Lahiri; George M Alley; Yuan-Wen Ge; Yansheng Du
Functional characterization of the 5'-regulatory region of the murine apolipoprotein gene.
Annals of the New York Academy of Sciences 2002;973():340-4.
2002: Stefan Nessler; Richard Dodel; Alwina Bittner; Stefanie Reuss; Yansheng Du; Bernhard Hemmer; Norbert Sommer
Effect of minocycline in experimental autoimmune encephalomyelitis.
Annals of neurology 2002;52(5):689-90; author reply 690.
2002: Feng Gao; Kelly R Bales; Richard Dodel; Junyi Liu; Xianming Chen; Harald Hample; Martin R Farlow; Steven M Paul; Yansheng Du
NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line.
Brain research. Molecular brain research 2002;105(1-2):108-14.
2002: Richard Dodel; Harald Hampel; Candan Depboylu; Suizhen Lin; Feng Gao; Sabine Schock; Steffi Jäckel; Xing Wei; Katharina Buerger; Christine Höft; Bernhard Hemmer; Hans-Jürgen Möller; Martin R Farlow; Wolfgang H Oertel; Norbert Sommer; Yansheng Du
Human antibodies against amyloid beta peptide: a potential treatment for Alzheimer's disease.
Annals of neurology 2002;52(2):253-6.
2002: Kara L Arvin; Byung H Han; Yansheng Du; Sui-zhen Lin; Steven M Paul; David M Holtzman
Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury.
Annals of neurology 2002;52(1):54-61.
2002: Richard Dodel; Yansheng Du; Candan Depboylu; Alexander Kurz; BJ Eastwood; Martin R Farlow; Wolfgang H Oertel; Ulrich Müller; Matthias Riemenschneider
A polymorphism in the cystatin C promoter region is not associated with an increased risk of AD.
Neurology 2002;58(4):664.
2001: Yansheng Du; Z Ma; Suizhen Lin; Richard Dodel; F Gao; Kelly R Bales; Lazaros C Triarhou; Eyassu Chernet; Kenneth W Perry; D L Nelson; S Luecke; Lee A Phebus; Frank P Bymaster; Steven M Paul
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14669-74.
2001: Suizhen Lin; Y Zhang; Richard Dodel; Martin R Farlow; Steven M Paul; Yansheng Du
Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons.
Neuroscience letters 2001;315(1-2):61-4.
2001: Yansheng Du; Richard Dodel; Harald Hampel; Katharina Buerger; S Lin; BJ Eastwood; K Bales; Feng Gao; H- J Moeller; Wolfgang H Oertel; Martin R Farlow; S Paul
Reduced levels of amyloid beta-peptide antibody in Alzheimer disease.
Neurology 2001;57(5):801-5.
2001: Richard Dodel; Frank Lohmüller; Yansheng Du; BJ Eastwood; Petra Gocke; Wolfgang H Oertel; Thomas Gasser
A polymorphism in the intronic region of the IL-1alpha gene and the risk for Parkinson's disease.
Neurology 2001;56(7):982-3.
2000: Yansheng Du; Richard Dodel; BJ Eastwood; Kelly R Bales; Feng Gao; Frank Lohmüller; Ulrich Müller; Alexander Kurz; R Zimmer; RM Evans; Ann Marie Hake; Thomas Gasser; Wolfgang H Oertel; W S Griffin; Steven M Paul; Martin R Farlow
Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.
Neurology 2000;55(4):480-3.
2000: Kelly R Bales; Yansheng Du; David M Holtzman; Barbara Cordell; Steven M Paul
Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.
Neurobiology of aging 2000;21(3):427-32; discussion 451-3.
2000: Richard Dodel; Yansheng Du; Kelly R Bales; Feng Gao; BJ Eastwood; Bradley S Glazier; R Zimmer; Barbara Cordell; Ann Marie Hake; R Evans; Dolores Gallagher-Thompson; Larry Wolford Thompson; Jared R Tinklenberg; A Pfefferbaum; Edith Sullivan; Jerome A Yesavage; L Alstiel; Thomas Gasser; Martin R Farlow; Greer M Murphy; Steven M Paul
Alpha2 macroglobulin and the risk of Alzheimer's disease.
Neurology 2000;54(2):438-42.
1999: Kelly R Bales; Tatyana Verina; D J Cummins; Yansheng Du; RC Dodel; Josep Saura; C E Fishman; Cynthia A DeLong; P Piccardo; Valérie Petegnief; Bernardino Ghetti; Steven M Paul
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15233-8.
1999: R C Dodel; Yansheng Du; Kelly R Bales; F Gao; Steven M Paul
Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides.
Journal of neurochemistry 1999;73(4):1453-60.
1999: X Liu; JA Clemens; T Yin; DT Stephenson; Edward M Johnstone; Yansheng Du; J A Panetta; Steven M Paul; Sheila P Little
Rat B(2) sequences are induced in the hippocampal CA1 region after transient global cerebral ischemia.
The Journal of biological chemistry 1999;274(40):28674-81.
1999: R C Dodel; Kelly R Bales; Martin R Farlow; T Gasser; S M Paul; Yansheng Du
Rapid detection of a pentanucleotide deletion polymorphism in the human alpha2-macroglobulin gene.
Clinical chemistry 1999;45(2):307-17.
1999: Richard Dodel; Yansheng Du; Kelly R Bales; Zaodung Ling; Paul Carvey; Steven M Paul
Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.
Brain research. Molecular brain research 1999;64(1):141-8.
1998: Richard Dodel; Yansheng Du; Kelly R Bales; ZD Ling; Paul Carvey; Steven M Paul
Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons.
Neuroscience 1998;86(3):701-7.
1998: Kelly R Bales; Yansheng Du; RC Dodel; G M Yan; E Hamilton-Byrd; Steven M Paul
The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation.
Brain research. Molecular brain research 1998;57(1):63-72.
1998: Yansheng Du; Kelly R Bales; RC Dodel; X Liu; MA Glinn; J W Horn; Sheila P Little; Steven M Paul
Alpha2-macroglobulin attenuates beta-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons.
Journal of neurochemistry 1998;70(3):1182-8.
1997: K R Bales; Tatyana Verina; R C Dodel; Yansheng Du; L Altstiel; M Bender; P Hyslop; Edward M Johnstone; Sheila P Little; D J Cummins; P Piccardo; Bernardino Ghetti; S M Paul
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
Nature genetics 1997;17(3):263-4.
1997: Yansheng Du; Kelly R Bales; RC Dodel; E Hamilton-Byrd; J W Horn; DL Czilli; L K Simmons; B Ni; Steven M Paul
Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11657-62.
1997: Yansheng Du; RC Dodel; Kelly R Bales; R Jemmerson; E Hamilton-Byrd; Steven M Paul
Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.
Journal of neurochemistry 1997;69(4):1382-8.
1997: Yansheng Du; B Ni; MA Glinn; R C Dodel; Kelly R Bales; Z Zhang; P A Hyslop; Steven M Paul
alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.
Journal of neurochemistry 1997;69(1):299-305.
1997: B Ni; X Wu; Yansheng Du; Y Su; E Hamilton-Byrd; P K Rockey; PR Rosteck; G G Poirier; Steven M Paul
Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(5):1561-9.
1996: B Ni; Yansheng Du; X Wu; B S DeHoff; PR Rosteck; S M Paul
Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter.
Journal of neurochemistry 1996;66(6):2227-38.