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James J-W Duan
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Network (preview)
23
Liu, Rui-Qin
21
Covington, Maryanne
21
Decicco, Carl
15
Newton, Robert
13
Trzaskos, James
12
Qian, Mingxin
11
Christ, David
11
Xue, Chu-Biao
10
Vaddi, Kris
8
Wasserman, Zelda
6
Gilmore, John
6
Roderick, John
6
Magolda, Ronald
5
Sheppeck, James
5
Hardman, Karl
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All Publications
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2008: Lu Zhonghui; Ott Gregory R; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James; Duan James J-W
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(6):1958-62.
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2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James M; Duan James J-W
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(5):1577-82.
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2008: Ott Gregory R; Asakawa Naoyuki; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna; Newton Robert C; Trzaskos James M; Christ David D; Galya Laurine; Scholz Thomas; Marshall Will; Duan James J-W
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(4):1288-92.
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2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Traskos James M; Decicco Carl P; Duan James J-W
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(2):694-9.
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2008: Duan James J-W; Chen Lihua; Lu Zhonghui; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Vaddi Krishna; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
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2007: Qian Mingxin; Bai Stephen A; Brogdon Bernice; Wu Jing-Tao; Liu Rui-Qin; Covington Maryanne B; Vaddi Kris; Newton Robert C; Fossler Michael J; Garner C Edwin; Deng Yuzhong; Maduskuie Thomas; Trzaskos James; Duan James J-W; Decicco Carl P; Christ David D
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1916-25.
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2007: Gilmore John L; King Bryan W; Asakawa Naoyuki; Harrison Kimberly; Tebben Andrew; Sheppeck James E; Liu Rui-Qin; Covington Maryanne; Duan James J-W
Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(16):4678-82.
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2007: Sheppeck James E; Gilmore John L; Tebben Andrew; Xue Chu-Biao; Liu Rui-Qin; Decicco Carl P; Duan James J-W
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(10):2769-74.
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2007: Chen Xiao-Tao; Ghavimi Bahman; Corbett Ronald L; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna G; Christ David D; Hartman Karl D; Ribadeneira Maria D; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1865-70.
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2007: Sheppeck James E; Gilmore John L; Yang Anle; Chen Xiao-Tao; Xue Chu-Biao; Roderick John; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P; Duan James J-W
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(5):1413-7.
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2007: Sheppeck James E; Tebben Andrew; Gilmore John L; Yang Anle; Wasserman Zelda R; Decicco Carl P; Duan James J-W
A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE.
Bioorganic & medicinal chemistry letters 2007;17(5):1408-12.
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2007: Barnett Joshua M; McCollum Gary W; Fowler Jessica A; Duan James J-W; Kay Jesse D; Liu Rui-Qin; Bingaman David P; Penn John S
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Investigative ophthalmology & visual science 2007;48(2):907-15.
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2007: Duan James J-W; Chen Lihua; Lu Zhonghui; Jiang Bin; Asakawa Naoyuki; Sheppeck James E; Liu Rui-Qin; Covington Maryanne B; Pitts William; Kim Soong-Hoon; Decicco Carl P
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(1):266-71.
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2006: Gilmore John L; King Bryan W; Harris Cathy; Maduskuie Thomas; Mercer Stephen E; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneria Maria D; Vaddi Krishna; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2699-704.
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2006: Cherney Robert J; King Bryan W; Gilmore John L; Liu Rui-Qin; Covington Maryanne B; Duan James J-W; Decicco Carl P
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(4):1028-31.
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2005: Duan James J-W; Lu Zhonghui; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Bioorganic & medicinal chemistry letters 2005;15(12):2970-3.
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2004: Xue Chu-Biao; Chen Xiao-Tao; He Xiaohua; Roderick John; Corbett Ronald L; Ghavimi Bahman; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Trzaskos James; Newton Robert C; Duan James J-W; Decicco Carl P
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(17):4453-9.
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2004: Wang Xinkang; Feuerstein Giora Z; Xu Lin; Wang Hugh; Schumacher William A; Ogletree Martin L; Taub Rebecca; Duan James J-W; Decicco Carl P; Liu Rui-Qin
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Molecular pharmacology 2004;65(4):890-6.
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2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Christ David D; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorganic & medicinal chemistry letters 2003;13(24):4299-304.
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2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Bioorganic & medicinal chemistry letters 2003;13(24):4293-7.
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2003: Duan James J-W; Lu Zhonghui; Xue Chu-Biao; He Xiaohua; Seng Jennifer L; Roderick John J; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Magolda Ronald L; Newton Robert C; Trzaskos James M; Decicco Carl P
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
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2003: Cherney Robert J; Duan James J-W; Voss Matthew E; Chen Lihua; Wang Li; Meyer Dayton T; Wasserman Zelda R; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Mandlekar Sandhya; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
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2003: Wasserman Zelda R; Duan James J-W; Voss Matthew E; Xue Chu Biao; Cherney Robert J; Nelson David J; Hardman Karl D; Decicco Carl P
Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.
Chemistry & biology 2003;10(3):215-23.
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2002: Duan James J-W; Chen Lihua; Wasserman Zelda R; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Hardman Karl D; Magolda Ronald L; Newton Robert C; Christ David D; Wexler Ruth R; Decicco Carl P
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
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2001: Xue C B; Voss M E; Nelson D J; Duan J J; Cherney R J; Jacobson I C; He X; Roderick J; Chen L; Corbett R L; Wang L; Meyer D T; Kennedy K; DeGradodagger W F; Hardman K D; Teleha C A; Jaffee B D; Liu R Q; Copeland R A; Covington M B; Christ D D; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 2001;44(16):2636-60.
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2000: Smith A B; Nittoli T; Sprengeler P A; Duan J J; Liu R Q; Hirschmann R F
Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.
Organic letters 2000;2(24):3809-12.
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1999: Duan J J; Chen L; Xue C B; Wasserman Z R; Hardman K D; Covington M B; Copeland R R; Arner E C; Decicco C P
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(10):1453-8.
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