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Wei Duan

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Wee Guan Lim; Xiao Chen; Jun-Ping Liu; Bee Jen Tan; Shufeng Zhou; Adam Smith; Nathaniel Lees; Liansheng Hou; Fukang Gu; Xi-Yong Yu; Yaomin Du; Derek Smith; Chandra Verma; Ke Liu; Wei Duan
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Weishi Zhang; Wei Duan; Nam Sang Cheung; Zhili Huang; Ke Shao; Qiu-Tian Li
Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells.
Xi-Yong Yu; Shu-Guang Lin; Zhi-Wei Zhou; Xiao Chen; Jun Liang; Xue-Qing Yu; Balram Chowbay; Jing-Yuan Wen; Wei Duan; Eli Chan; Xiao-Tian Li; Jie Cao; Chun-Guang Li; Charlie Changli Xue; Shu-Feng Zhou
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.

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All Publications

2008: Wee Guan Lim; Xiao Chen; Jun-Ping Liu; Bee Jen Tan; Shufeng Zhou; Adam Smith; Nathaniel Lees; Liansheng Hou; Fukang Gu; Xi-Yong Yu; Yaomin Du; Derek Smith; Chandra Verma; Ke Liu; Wei Duan
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Archives of biochemistry and biophysics 2008;479(2):170-8.
2007: Weishi Zhang; Wei Duan; Nam Sang Cheung; Zhili Huang; Ke Shao; Qiu-Tian Li
Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells.
Journal of neurochemistry 2007;103(3):1157-67.
2007: Xi-Yong Yu; Shu-Guang Lin; Zhi-Wei Zhou; Xiao Chen; Jun Liang; Xue-Qing Yu; Balram Chowbay; Jing-Yuan Wen; Wei Duan; Eli Chan; Xiao-Tian Li; Jie Cao; Chun-Guang Li; Charlie Changli Xue; Shu-Feng Zhou
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.
Pharmaceutical research 2007;24(9):1668-90.
2007: Xi-Yong Yu; Shu-Guang Lin; Zhi-Wei Zhou; Xiao Chen; Jun Liang; Wei Duan; Xue-Qing Yu; Jing-Yuan Wen; Balram Chowbay; Chun-Guang Li; Fwu-Shan Sheu; Eli Chan; Shu-Feng Zhou
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.
Neuroscience letters 2007;417(3):261-5.
2007: Xi-Yong Yu; Shu-Guang Lin; Xiao Chen; Zhi-Wei Zhou; Jun Liang; Wei Duan; Balram Chowbay; Jing-Yuan Wen; Eli Chan; Jie Cao; Chun-Guang Li; Shu-Feng Zhou
Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.
Current drug metabolism 2007;8(4):365-78.
2007: Xi-Yong Yu; Shu-Guang Lin; Zhi-Wei Zhou; Xiao Chen; Jun Liang; Pei-Qing Liu; Wei Duan; Balram Chowbay; Jing-Yuan Wen; Chun-Guang Li; Shu-Feng Zhou
Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.
Current drug metabolism 2007;8(4):325-40.
2007: Zeping Hu; Xiao-Xia Yang; Xiao Chen; Eli Chan; Wei Duan; Shu-Feng Zhou
Simultaneous determination of irinotecan (CPT-11) and SN-38 in tissue culture media and cancer cells by high performance liquid chromatography: application to cellular metabolism and accumulation studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):575-80.
2007: Xi-Yong Yu; Zhi-Wei Zhou; Shu-Guang Lin; Xiao Chen; Xue-Qing Yu; Jun Liang; Wei Duan; Jing-Yuan Wen; Xiao-Tian Li; Shu-Feng Zhou
Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(4):375-415.
2007: Zeping Hu; Xiao-Xia Yang; Xiao Chen; Jie Cao; Eli Chan; Wei Duan; Min Huang; Xue-Qing Yu; Jing-Yuan Wen; Shu-Feng Zhou
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.
Current drug metabolism 2007;8(2):157-71.
2007: Ke Shao; Qingsong Hou; Mei-Lin Go; Wei Duan; Nam Sang Cheung; Si-Shen Feng; Kim Ping Wong; A Yoram; W Zhang; Zhili Huang; Qiu-Tian Li
Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells.
Cellular and molecular life sciences : CMLS 2007;64(4):506-15.
2006: Zeping Hu; Xiao-Xia Yang; Sui Yung Chan; An-Long Xu; Wei Duan; Yi-Zhun Zhu; Fwu-Shan Sheu; Urs A Boelsterli; Eli Chan; Qiang Zhang; Jian-Cheng Wang; Pui Lai Rachel Ee; Hwee-Ling Koh; Min Huang; Shu-Feng Zhou
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.
Toxicology and applied pharmacology 2006;216(2):225-37.
2006: Sui Sum Yeong; Yimin Zhu; Derek Smith; Chandra Verma; Wee Guan Lim; Bee Jen Tan; Qiu-Tian Li; Nam Sang Cheung; Minnie Cai; Yi-Zhun Zhu; Shu-Feng Zhou; Seng-Lai Tan; Wei Duan
The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha.
The Journal of biological chemistry 2006;281(41):30768-81.
2006: Ke Shao; Qingsong Hou; Wei Duan; Mei-Lin Go; Kim Ping Wong; Qiu-Tian Li
Intracellular drug delivery by sulfatide-mediated liposomes to gliomas.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(2):150-7.
2006: Shilong Zhong; Min Huang; Xiuyan Yang; Liuqin Liang; Yixi Wang; Marjorie Romkes; Wei Duan; Eli Chan; Shu-Feng Zhou
Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus.
British journal of clinical pharmacology 2006;62(4):457-72.
2006: Xiao-Xia Yang; Zeping Hu; An-Long Xu; Wei Duan; Yi-Zhun Zhu; Min Huang; Fwu-Shan Sheu; Qiang Zhang; Jin-Song Bian; Eli Chan; Xiaotian Li; Jian-Cheng Wang; Shu-Feng Zhou
A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor.
The Journal of pharmacology and experimental therapeutics 2006;319(1):82-104.
2006: Chor Hui Vivien Koh; Robert Z Qi; Dianbo Qu; Alirio J Melendez; Manikandan Jayapal; Boon-Huat Bay; Wei Duan; Nam Sang Cheung
U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases.
Cellular signalling 2006;18(10):1572-83.
2006: Su Guan; Min Huang; Eli Chan; Xiao Chen; Wei Duan; Shu-Feng Zhou
Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(1):14-21.
2006: Jie Chen; Xiao-Xia Yang; Min Huang; Zeping Hu; Ming He; Wei Duan; Eli Chan; Fwu-Shan Sheu; Xiao Chen; Shu-Feng Zhou
Small interfering RNA-mediated silencing of cytochrome P450 3A4 gene.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1650-7.
2006: Wee Guan Lim; Bee Jen Tan; Yimin Zhu; Shufeng Zhou; Jeffrey S Armstrong; Qiu-Tian Li; Qihan Dong; Eli Chan; Derek Smith; Chandra Verma; Seng-Lai Tan; Wei Duan
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Cellular signalling 2006;18(9):1473-81.
2006: Li-zi Zhao; Ming Huang; Jie Chen; Pui Lai Rachel Ee; Eli Chan; Wei Duan; Yong-Yuna Guan; Yun-Han Hong; Xiao Chen; Shufeng Zhou
Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.
Current drug metabolism 2006;7(6):577-87.
2006: Xiao-Xia Yang; Ze-Ping Hu; Eli Chan; Wei Duan; Shufeng Zhou
Pharmacokinetics of recombinant human endostatin in rats.
Current drug metabolism 2006;7(6):565-76.
2006: Piek Ngoh Chang; Jian Chun Mao; Shan Hong Huang; Li Ning; Zhong Jing Wang; Todd On; Wei Duan; Yi-Zhun Zhu
Analysis of cardioprotective effects using purified Salvia miltiorrhiza extract on isolated rat hearts.
Journal of pharmacological sciences 2006;101(3):245-9.
2006: Jing Zhang; Min Huang; Su Guan; Hui-Chang Bi; Ying Pan; Wei Duan; Sui Yung Chan; Xiao Chen; Yun-Han Hong; Jin-Song Bian; Hong-Yuan Yang; Shufeng Zhou
A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1285-94.
2006: Yimin Zhu; Derek Smith; Chandra Verma; Wee Guan Lim; Bee Jen Tan; Jeffrey S Armstrong; Shufeng Zhou; Eli Chan; Seng-Lai Tan; Yi-Zhun Zhu; Nam Sang Cheung; Wei Duan
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1.
Cellular signalling 2006;18(6):807-18.
2006: Xiao-Xia Yang; Zeping Hu; Sui Yung Chan; Wei Duan; Paul C Ho; Urs A Boelsterli; Ka-yun Ng; Eli Chan; Jin-Song Bian; Yu Zong Chen; Min Huang; Shu-Feng Zhou
Pharmacokinetic mechanisms for reduced toxicity of irinotecan by coadministered thalidomide.
Current drug metabolism 2006;7(4):431-55.
2006: Shi-long Zhong; Shu-Feng Zhou; Xiao Chen; Sui Yung Chan; Eli Chan; Ka-yun Ng; Wei Duan; Min Huang
Relationship between genotype and enzyme activity of glutathione S-transferases M1 and P1 in Chinese.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(1-2):77-85.
2006: Kian Ping Loh; L S Low; W H Wong; Shufeng Zhou; S H Huang; R De Silva; Wei Duan; W H Chou; Yi-Zhun Zhu
A comparison study of cerebral protection using Ginkgo biloba extract and Losartan on stroked rats.
Neuroscience letters 2006;398(1-2):28-33.
2006: Minghui Jessica Chen; Yann Wan Yap; Meng Shyan Choy; Chor Hui Vivien Koh; Sze Jee Seet; Wei Duan; Matthew Whiteman; Nam Sang Cheung
Early induction of calpains in rotenone-mediated neuronal apoptosis.
Neuroscience letters 2006;397(1-2):69-73.
2006: Eli Chan; Shufeng Zhou; Sahasranaman Srikumar; Wei Duan
Use of in vitro critical inhibitory concentration, a novel approach to predict in vivo synergistic bactericidal effect of combined amikacin and piperacillin against Pseudomonas aeruginosa in a systemic rat infection model.
Pharmaceutical research 2006;23(4):729-41.
2006: Xiao Chen; Zeping Hu; Xiao-Xia Yang; Min Huang; Yihuai Gao; Wenbo Tang; Sui Yung Chan; Xihu Dai; Jinxian Ye; Paul C Ho; Wei Duan; Hong-Yuan Yang; Yi-Zhun Zhu; Shu-Feng Zhou
Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer.
International immunopharmacology 2006;6(3):499-508.
2006: Matthew Whiteman; Yeow Leng Chua; Dawei Zhang; Wei Duan; Yih-Cherng Liou; Jeffrey S Armstrong
Nitric oxide protects against mitochondrial permeabilization induced by glutathione depletion: role of S-nitrosylation?
Biochemical and biophysical research communications 2006;339(1):255-62.
2006: Yang Zhang; Jun Ding; Wei Duan
A study of the effects of flux density and frequency of pulsed electromagnetic field on neurite outgrowth in PC12 cells.
Journal of biological physics 2006;32(1):1-9.
2006: Xiao-Xia Yang; Zeping Hu; Wei Duan; Yi-Zhun Zhu; Shu-Feng Zhou
Drug-herb interactions: eliminating toxicity with hard drug design.
Current pharmaceutical design 2006;12(35):4649-64.
2006: Quan Tian; Jing Zhang; Sui Yung Chan; Theresa May Chin Tan; Wei Duan; Min Huang; Yi-Zhun Zhu; Eli Chan; Qiang Yu; Yu-Qiang Nie; Paul C Ho; Qi Li; Ka-yun Ng; Hong-Yuan Yang; Hong Wei; Jin-Song Bian; Shu-Feng Zhou
Topotecan is a substrate for multidrug resistance associated protein 4.
Current drug metabolism 2006;7(1):105-18.
2005: Quan Tian; Jing Zhang; Theresa May Chin Tan; Eli Chan; Wei Duan; Sui Yung Chan; Urs A Boelsterli; Paul C Ho; Hongyuan Yang; Jin-Song Bian; Min Huang; Yi-Zhun Zhu; Weiping Xiong; Xiaotian Li; Shufeng Zhou
Human multidrug resistance associated protein 4 confers resistance to camptothecins.
Pharmaceutical research 2005;22(11):1837-53.
2005: Jing Li; Shufeng Zhou; Hung Huynh; Wei Duan; Eli Chan
Alteration of the pharmacokinetics of COL-3, a matrix metalloproteinase inhibitor, due to acute gastrointestinal toxicity of doxorubicin.
Pharmaceutical research 2005;22(11):1954-63.
2005: Jing Zhang; Quan Tian; Sui Yung Chan; Wei Duan; Shufeng Zhou
Insights into oxazaphosphorine resistance and possible approaches to its circumvention.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(5):271-97.
2005: Penghua Wang; Wei Duan; Alan L Munn; Hongyuan Yang
Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae.
The FEBS journal 2005;272(18):4703-15.
2005: Xiaoxia Yang; Zeping Hu; Sui Yung Chan; Paul C Ho; Eli Chan; Wei Duan; Boon Cher Goh; Shufeng Zhou
Determination of thalidomide by high performance liquid chromatography: plasma pharmacokinetic studies in the rat.
Journal of pharmaceutical and biomedical analysis 2005;39(1-2):299-304.
2005: Yimin Zhu; Wee Guan Lim; Bee Jen Tan; Tian Seng Teo; Wei Duan
Identification of an integral plasma membrane pool of protein kinase C in mammalian tissues and cells.
Cellular signalling 2005;17(9):1125-36.
2005: Wee Guan Lim; Yimin Zhu; Chern-Hoe Wang; Bee Jen Tan; Jeffrey S Armstrong; Terje Dokland; Hongyuan Yang; Yi-Zhun Zhu; Tian Seng Teo; Wei Duan
The last five amino acid residues at the C-terminus of PRK1/PKN is essential for full lipid responsiveness.
Cellular signalling 2005;17(9):1084-97.
2005: Xiaoxia Yang; Zeping Hu; Sui Yung Chan; Boon Cher Goh; Wei Duan; Eli Chan; Shufeng Zhou
Simultaneous determination of the lactone and carboxylate forms of irinotecan (CPT-11) and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in the rat.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(2):221-8.
2005: Shufeng Zhou; Min Huang; Anlong Xu; Hongyuan Yang; Wei Duan; James W Paxton
Prediction of herb-drug metabolic interactions: a simulation study.
Phytotherapy research : PTR 2005;19(6):464-71.
2005: Zeping Hu; Xiaoxia Yang; Paul C Ho; Eli Chan; Sui Yung Chan; Congjian Xu; Xiaotian Li; Yi-Zhun Zhu; Wei Duan; Xiao Chen; Min Huang; Hongyuan Yang; Shufeng Zhou
St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats.
Pharmaceutical research 2005;22(6):902-14.
2005: Yimin Zhu; Qihan Dong; Bee Jen Tan; Wee Guan Lim; Shufeng Zhou; Wei Duan
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals.
Cancer research 2005;65(11):4520-4.
2005: Jian Sun; Shan Hong Huang; Benny K H Tan; Matthew Whiteman; Yi Chun Zhu; Ya Jun Wu; Yeekong Ng; Wei Duan; Yi-Zhun Zhu
Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction.
Life sciences 2005;76(24):2849-60.
2005: Wei Duan; Jasmine H P Chan; Kelly McKay; Jeffrey R Crosby; Hui Hwa Choo; Bernard P Leung; James G Karras; W S Fred Wong
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.
American journal of respiratory and critical care medicine 2005;171(6):571-8.
2005: Wei Duan; Ana M K Aguinaldo Datiles; Bernard P Leung; chris vlahos; W S Fred Wong
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model.
International immunopharmacology 2005;5(3):495-502.
2005: Jing Zhang; Quan Tian; Sui Yung Chan; Shu Chuen Li; Shufeng Zhou; Wei Duan; Yi-Zhun Zhu
Metabolism and transport of oxazaphosphorines and the clinical implications.
Drug metabolism reviews 2005;37(4):611-703.
2005: Xiaoxia Yang; Zeping Hu; Sui Yung Chan; Eli Chan; Boon Cher Goh; Wei Duan; Shufeng Zhou
Novel agents that potentially inhibit irinotecan-induced diarrhea.
Current medicinal chemistry 2005;12(11):1343-58.
2005: Zeping Hu; Xiaoxia Yang; Paul C Ho; Sui Yung Chan; Paul Wan Sia Heng; Eli Chan; Wei Duan; Hwee-Ling Koh; Shufeng Zhou
Herb-drug interactions: a literature review.
Drugs 2005;65(9):1239-82.
2005: Shufeng Zhou; Sui Yung Chan; Boon Cher Goh; Eli Chan; Wei Duan; Min Huang; howard mcleod
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.
Clinical pharmacokinetics 2005;44(3):279-304.
2005: Shufeng Zhou; Eli Chan; Wei Duan; Min Huang; Yu Zong Chen
Drug bioactivation, covalent binding to target proteins and toxicity relevance.
Drug metabolism reviews 2005;37(1):41-213.
2004: Jeffrey S Armstrong; Hongyuan Yang; Wei Duan; Matthew Whiteman
Cytochrome bc(1) regulates the mitochondrial permeability transition by two distinct pathways.
The Journal of biological chemistry 2004;279(48):50420-8.
2004: Yimin Zhu; Donna B Stolz; Fengli Guo; Mark A Ross; simon simon watkins; Bee Jen Tan; Robert Z Qi; Ed Manser; Qiu-Tian Li; Boon-Huat Bay; Tian Seng Teo; Wei Duan
Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1722-4.
2004: Cherng-Jye Seow; Sung-Chian Chue; Wei Duan; K S L Yeo; Alan H M Koh; W S Fred Wong
Effects of inhibitors of the tyrosine signalling cascade on antigen challenge of guinea pig airways in vitro.
Annals of the Academy of Medicine, Singapore 2004;33(5 Suppl):S41-3.
2004: Sung-Chian Chue; Cherng-Jye Seow; Wei Duan; K S Leonard Yeo; Alan H M Koh; W S Fred Wong
Inhibitor of p42/44 mitogen-activated protein kinase, but not p38 MAPK, attenuated antigen challenge of guinea pig airways in vitro.
International immunopharmacology 2004;4(8):1089-98.
2004: Wei Duan; Jasmine H P Chan; Chui Hong Wong; Bernard P Leung; W S Fred Wong
Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7053-9.
2003: Wei Duan; I-Chun Kuo; Sathiyamoorthy Selvarajan; Kaw Yan Chua; Boon-Huat Bay; W S Fred Wong
Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma.
American journal of respiratory and critical care medicine 2003;167(2):185-92.
2002: Rongxian Jin; Vincent T K Chow; Puay Hoon Tan; S Thameem Dheen; Wei Duan; Boon-Huat Bay
Metallothionein 2A expression is associated with cell proliferation in breast cancer.
Carcinogenesis 2002;23(1):81-6.
2001: T Li; Wei Duan; Hongyuan Yang; M K Lee; F Bte Mustafa; B H Lee; Tian Seng Teo
Identification of two proteins, S14 and UIP1, that interact with UCH37.
FEBS letters 2001;488(3):201-5.
2000: Wei Duan; B Sun; T W Li; Bee Jen Tan; M K Lee; Tian Seng Teo
Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo.
Gene 2000;256(1-2):113-21.