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Raymond DuBois

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
24
Sheng, Hongmiao
23
Wang, Dingzhi
19
Shao, Jinyi
19
Dey, Sudhansu
18
Gupta, Rajnish
17
Williams, Christopher
16
Beauchamp, Daniel
14
Buchanan, Gregory
13
Morrow, Jason
11
Mann, Jason
8
Backlund, Michael
8
Holla, Vijaykumar
8
Wang, Haibin
7
Katkuri, Sharada
7
Das, Sanjoy

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Publications

TOP 3
Dubois Raymond N
New, long-term insights from the Adenoma Prevention with Celecoxib Trial on a promising but troubled class of drugs.
Pedchenko Tetyana V; Gonzalez Adriana L; Wang DingZhi; DuBois Raymond N; Massion Pierre P
Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.
Backlund Michael G; Mann Jason R; Holla Vijaykumar R; Shi Qiong; Daikoku Takikoku; Dey Sudhansu K; DuBois Raymond N
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.

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All Publications

2009: Dubois Raymond N
New, long-term insights from the Adenoma Prevention with Celecoxib Trial on a promising but troubled class of drugs.
Cancer prevention research (Philadelphia, Pa.) 2009;2(4):285-7.
2008: Pedchenko Tetyana V; Gonzalez Adriana L; Wang DingZhi; DuBois Raymond N; Massion Pierre P
Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer.
American journal of respiratory cell and molecular biology 2008;39(6):689-96.
2008: Backlund Michael G; Mann Jason R; Holla Vijaykumar R; Shi Qiong; Daikoku Takikoku; Dey Sudhansu K; DuBois Raymond N
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer.
Cancer research 2008;68(22):9331-7.
2008: Wang Dingzhi; Wang Haibin; Ning Wei; Backlund Michael G; Dey Sudhansu K; DuBois Raymond N
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth.
Cancer research 2008;68(15):6468-76.
2008: Wang Dingzhi; DuBois Raymond N
Pro-inflammatory prostaglandins and progression of colorectal cancer.
Cancer letters 2008;267(2):197-203.
2008: Holla Vijaykumar R; Backlund Michael G; Yang Peying; Newman Robert A; DuBois Raymond N
Regulation of prostaglandin transporters in colorectal neoplasia.
Cancer prevention research (Philadelphia, Pa.) 2008;1(2):93-9.
2008: Wang Dingzhi; Dubois Raymond N
Peroxisome proliferator-activated receptors and progression of colorectal cancer.
PPAR research 2008;2008():931074.
2007: Wang Haibin; Xie Huirong; Sun Xiaofei; Tranguch Susanne; Zhang Hao; Jia Xiangxu; Wang Dingzhi; Das Sanjoy K; Desvergne Béatrice; Wahli Walter; DuBois Raymond N; Dey Sudhansu K
Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.
The Journal of biological chemistry 2007;282(52):37770-82.
2007: Lee Seon Hwa; Rangiah Kannan; Williams Michelle V; Wehr Angela Y; DuBois Raymond N; Blair Ian A
Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells.
Chemical research in toxicology 2007;20(11):1665-75.
2007: Buchanan F Gregory; Holla Vijay; Katkuri Sharada; Matta Pranathi; DuBois Raymond N
Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer.
Cancer research 2007;67(19):9380-8.
2007: Horikawa Youhei; Otaka Michiro; Komatsu Koga; Jin Mario; Odashima Masaru; Wada Isao; Matsuhashi Tamotsu; Ohba Reina; Oyake Jinko; Hatakeyama Natsumi; Dubois Raymond N; Watanabe Sumio
MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism.
Digestive diseases and sciences 2007;52(10):2757-65.
2007: Daikoku Takiko; Tranguch Susanne; Chakrabarty Anindita; Wang Dingzhi; Khabele Dineo; Orsulic Sandra; Morrow Jason D; Dubois Raymond N; Dey Sudhansu K
Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer.
Cancer research 2007;67(11):5285-92.
2007: Wang Dingzhi; DuBois Raymond N
Inflammatory mediators and nuclear receptor signaling in colorectal cancer.
Cell cycle (Georgetown, Tex.) 2007;6(6):682-5.
2007: Wang Dingzhi; DuBois Raymond N
Measurement of eicosanoids in cancer tissues.
Methods in enzymology 2007;433():27-50.
2007: Cha Yong I; DuBois Raymond N
NSAIDs and cancer prevention: targets downstream of COX-2.
Annual review of medicine 2007;58():239-52.
2006: Wang Dingzhi; Wang Haibin; Guo Yong; Ning Wei; Katkuri Sharada; Wahli Walter; Desvergne Beatrice; Dey Sudhansu K; DuBois Raymond N
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19069-74.
2006: Buchanan F Gregory; DuBois Raymond N
Emerging roles of beta-arrestins.
Cell cycle (Georgetown, Tex.) 2006;5(18):2060-3.
2006: Mann Jason R; Backlund Michael G; Buchanan F Gregory; Daikoku Taki; Holla Vijaykumar R; Rosenberg Daniel W; Dey Sudhansu K; DuBois Raymond N
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.
Cancer research 2006;66(13):6649-56.
2006: DuBois Raymond N
Cyclooxygenase-2 selective inhibitors and prostate cancer: what is the clinical benefit?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(18):2691-3.
2006: DuBois Raymond N
Cancer prevention: strategy for the future.
Carcinogenesis 2006;27(6):1126-7.
2006: Batts Lorene E; Polk D Brent; Dubois Raymond N; Kulessa Holger
Bmp signaling is required for intestinal growth and morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2006;235(6):1563-70.
2006: Wang Dingzhi; Wang Haibin; Brown Joanne; Daikoku Takiko; Ning Wei; Shi Qiong; Richmond Ann; Strieter Robert; Dey Sudhansu K; DuBois Raymond N
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer.
The Journal of experimental medicine 2006;203(4):941-51.
2006: DuBois Raymond N
NSAIDs and prostate cancer risk.
Cancer journal (Sudbury, Mass.) 2006;12(2):108-9.
2006: Holla Vijaykumar R; Mann Jason R; Shi Qiong; DuBois Raymond N
Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer.
The Journal of biological chemistry 2006;281(5):2676-82.
2006: Buchanan F Gregory; Gorden D Lee; Matta Pranathi; Shi Qiong; Matrisian Lynn M; DuBois Raymond N
Role of beta-arrestin 1 in the metastatic progression of colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1492-7.
2006: Buchanan F Gregory; DuBois Raymond N
Connecting COX-2 and Wnt in cancer.
Cancer cell 2006;9(1):6-8.
2006: DuBois Raymond N
The COX-2 story: is any drug completely "safe?".
Gastroenterology 2006;130(1):6.
2006: Cha Yong I; Kim Seok-Hyung; Sepich Diane; Buchanan F Gregory; Solnica-Krezel Lilianna; DuBois Raymond N
Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation.
Genes & development 2006;20(1):77-86.
2006: Cha Yong I; Solnica-Krezel Lilianna; DuBois Raymond N
Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins.
Developmental biology 2006;289(2):263-72.
2006: Komatsu Koga; Buchanan F Gregory; Otaka Michiro; Jin Mario; Odashima Masaru; Horikawa Yohei; Watanabe Sumio; Dubois Raymond N
Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.
Molecular cancer 2006;5():63.
2006: Backlund Michael G; Mann Jason R; Wang Dingzhi; Dubois Raymond N
Ras up-regulation of cyclooxygenase-2.
Methods in enzymology 2006;407():401-10.
2005: Peek Richard M; Mohla Suresh; DuBois Raymond N
Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting.
Cancer research 2005;65(19):8583-6.
2005: Musiek Erik S; Gao Ling; Milne Ginger L; Han Wei; Everhart M Brett; Wang Dingzhi; Backlund Michael G; DuBois Raymond N; Zanoni Giuseppe; Vidari Giovanni; Blackwell Timothy S; Morrow Jason D
Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.
The Journal of biological chemistry 2005;280(42):35562-70.
2005: Komatsu Koga; Buchanan F Gregory; Katkuri Sharada; Morrow Jason D; Inoue Hiroyasu; Otaka Michiro; Watanabe Sumio; DuBois Raymond N
Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2.
Gastroenterology 2005;129(2):577-90.
2005: Lee Seon Hwa; Williams Michelle V; Dubois Raymond N; Blair Ian A
Cyclooxygenase-2-mediated DNA damage.
The Journal of biological chemistry 2005;280(31):28337-46.
2005: Cha Yong I; Kim Seok-Hyung; Solnica-Krezel Lilianna; Dubois Raymond N
Cyclooxygenase-1 signaling is required for vascular tube formation during development.
Developmental biology 2005;282(1):274-83.
2005: Wang Dingzhi; Mann Jason R; DuBois Raymond N
The role of prostaglandins and other eicosanoids in the gastrointestinal tract.
Gastroenterology 2005;128(5):1445-61.
2005: Daikoku Takiko; Wang Dingzhi; Tranguch Susanne; Morrow Jason D; Orsulic Sandra; DuBois Raymond N; Dey Sudhansu K
Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.
Cancer research 2005;65(9):3735-44.
2005: Mann Jason R; Backlund Michael G; DuBois Raymond N
Mechanisms of disease: Inflammatory mediators and cancer prevention.
Nature clinical practice. Oncology 2005;2(4):202-10.
2005: Brown Joanne R; DuBois Raymond N
COX-2: a molecular target for colorectal cancer prevention.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(12):2840-55.
2005: Wang Dingzhi; Buchanan F Gregory; Wang Haibin; Dey Sudhansu K; DuBois Raymond N
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
Cancer research 2005;65(5):1822-9.
2005: Buchanan F Gregory; McReynolds Matt; Couvillon Anthony; Kam Yoonseok; Holla Vijaykumar R; Dubois Raymond N; Exton John H
Requirement of phospholipase D1 activity in H-RasV12-induced transformation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1638-42.
2005: Backlund Michael G; Mann Jason R; Holla Vijaykumar R; Buchanan F Gregory; Tai Hsin-Hsiung; Musiek Erik S; Milne Ginger L; Katkuri Sharada; DuBois Raymond N
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer.
The Journal of biological chemistry 2005;280(5):3217-23.
2005: Dannenberg Andrew J; Lippman Scott M; Mann Jason R; Subbaramaiah Kotha; DuBois Raymond N
Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(2):254-66.
2005: Holla Vijaykumar R; Wang Dingzhi; Brown Joanne R; Mann Jason R; Katkuri Sharada; DuBois Raymond N
Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer.
The Journal of biological chemistry 2005;280(1):476-83.
2005: Backlund Michael G; Mann Jason R; Dubois Raymond N
Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2.
Oncology 2005;69 Suppl 1():28-32.
2004: Wang Dingzhi; Mann Jason R; DuBois Raymond N
WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth.
Cell cycle (Georgetown, Tex.) 2004;3(12):1512-5.
2004: Buchanan F Gregory; Chang Woogki; Sheng Hongmiao; Shao Jinyi; Morrow Jason D; DuBois Raymond N
Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor.
Gastroenterology 2004;127(5):1391-400.
2004: Dubois Raymond N
Disease prevention: the future is here.
Gastroenterology 2004;127(5):1289.
2004: Wang Haibin; Guo Yong; Wang Dingzhi; Kingsley Philip J; Marnett Lawrence J; Das Sanjoy K; DuBois Raymond N; Dey Sudhansu K
Aberrant cannabinoid signaling impairs oviductal transport of embryos.
Nature medicine 2004;10(10):1074-80.
2004: Wang Dingzhi; Wang Haibin; Shi Qiong; Katkuri Sharada; Walhi Walter; Desvergne Beatrice; Das Sanjoy K; Dey Sudhansu K; DuBois Raymond N
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta.
Cancer cell 2004;6(3):285-95.
2004: Organ Edward L; Nalbantyan Christopher D; Nanney Lillian B; Woodward Stephen C; Sheng Jinsong; Dubois Raymond N; Price James; Sutcliffe Marilyn; Coffey Robert J; Rubin Donald H
Effects of transforming growth factor-alpha (TGF-alpha) in vitro and in vivo on reovirus replication.
DNA and cell biology 2004;23(7):430-41.
2004: Brown Joanne R; DuBois Raymond N
Cyclooxygenase as a target in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 2):4266s-4269s.
2004: Lynch Thomas J; Adjei Alex A; Bunn Paul A; DuBois Raymond N; Gandara David R; Giaccone Giuseppe; Govindan Ramaswamy; Herbst Roy S; Johnson Bruce E; Khuri Fadlo R; Perez-Soler Roman; Rosell Rafael; Rowinsky Eric K; Sandler Alan B; Scagliotti Giorgio V; Schiller Joan H; Shapiro Geoffrey I; Socinski Mark A; Hart Carol S
Novel agents in the treatment of lung cancer: conference summary statement.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 2):4199s-4204s.
2004: Mann Jason R; DuBois Raymond N
Cyclooxygenase-2 and gastrointestinal cancer.
Cancer journal (Sudbury, Mass.) 2004;10(3):145-52.
2004: DuBois Raymond N
Aspirin and breast cancer prevention: the estrogen connection.
JAMA : the journal of the American Medical Association 2004;291(20):2488-9.
2004: Brown Joanne R; DuBois Raymond N
Cyclooxygenase-2 in lung carcinogenesis and chemoprevention: Roger S. Mitchell lecture.
Chest 2004;125(5 Suppl):134S-40S.
2004: Koehne Claus-Henning; Dubois Raymond N
COX-2 inhibition and colorectal cancer.
Seminars in oncology 2004;31(2 Suppl 7):12-21.
2004: Gupta Rajnish A; Wang Dingzhi; Katkuri Sharada; Wang Haibin; Dey Sudhansu K; DuBois Raymond N
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth.
Nature medicine 2004;10(3):245-7.
2004: Wang Dingzhi; Dubois Raymond N
Cyclooxygenase-2: a potential target in breast cancer.
Seminars in oncology 2004;31(1 Suppl 3):64-73.
2004: Yoshinaga Masahiro; Buchanan F Gregory; DuBois Raymond N
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Prostaglandins & other lipid mediators 2004;73(1-2):111-22.
2004: Wang Dingzhi; DuBois Raymond N
Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):415-6.
2003: Dubois Raymond N
The physician-scientist in gastroenterology.
Gastroenterology 2003;125(3):652.
2003: Buchanan F Gregory; Wang Dingzhi; Bargiacchi Francesca; DuBois Raymond N
Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor.
The Journal of biological chemistry 2003;278(37):35451-7.
2003: Dubois Raymond N
Will an aspirin a day keep the endoscope away?
Gastroenterology 2003;125(2):612-4.
2003: DuBois Raymond N
Leukotriene A4 signaling, inflammation, and cancer.
Journal of the National Cancer Institute 2003;95(14):1028-9.
2003: Gupta Rajnish A; Sarraf Pasha; Mueller Elisabetta; Brockman Jeffrey A; Prusakiewicz Jeffery J; Eng Charis; Willson Timothy M; DuBois Raymond N
Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms.
The Journal of biological chemistry 2003;278(25):22669-77.
2003: Crosby Colin G; DuBois Raymond N
The cyclooxygenase-2 pathway as a target for treatment or prevention of cancer.
Expert opinion on emerging drugs 2003;8(1):1-7.
2003: Wagenaar-Miller R A; Hanley G; Shattuck-Brandt R; DuBois R N; Bell R L; Matrisian L M; Morgan D W
Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction.
British journal of cancer 2003;88(9):1445-52.
2003: Berger David H; O'Mahony Christine A; Sheng Hongmiao; Shao Jinyi; Albo Daniel; DuBois Raymond N; Beauchamp R Daniel
Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions.
Surgery 2003;133(5):568-79.
2003: DuBois Raymond N
Evaluation of the whole prostaglandin biosynthetic pathway in lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1577-8.
2003: Gupta Rajnish A; Tejada Lovella V; Tong Beverly J; Das Sanjoy K; Morrow Jason D; Dey Sudhansu K; DuBois Raymond N
Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer.
Cancer research 2003;63(5):906-11.
2003: Daikoku Takiko; Matsumoto Hiromichi; Gupta Rajnish A; Das Sanjoy K; Gassmann Max; DuBois Raymond N; Dey Sudhansu K
Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy.
The Journal of biological chemistry 2003;278(9):7683-91.
2003: Gupta Rajnish A; Sarraf Pasha; Brockman Jeffrey A; Shappell Scott B; Raftery Laurel A; Willson Timothy M; DuBois Raymond N
Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.
The Journal of biological chemistry 2003;278(9):7431-8.
2003: Lee Seon Hwa; Williams Michelle V; DuBois Raymond N; Blair Ian A
Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(19):2168-76.
2003: DuBois Raymond N
Cyclooxygenase-2 and colorectal cancer.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 2003;37():124-37.
2002: Gupta Rajnish A; DuBois Raymond N; Wallace Mina C
New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity.
Best practice & research. Clinical gastroenterology 2002;16(6):945-56.
2002: DuBois Raymond N
New agents for cancer prevention.
Journal of the National Cancer Institute 2002;94(23):1732-3.
2002: Turini Marco E; DuBois Raymond N
Primary prevention: phytoprevention and chemoprevention of colorectal cancer.
Hematology/oncology clinics of North America 2002;16(4):811-40.
2002: DuBois Raymond N
Modern academic medicine.
The American journal of the medical sciences 2002;324(2):55-6.
2002: Gupta Rajnish A; Dubois Raymond N
Controversy: PPARgamma as a target for treatment of colorectal cancer.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(2):G266-9.
2002: Simon Lee S; Smolen Josef S; Abramson Steven B; Appel Gerald; Bombardier Claire; Brater D Craig; Breedveld Ferdinand C; Brune K; Burmester Gerd R; Crofford Leslie J; Dougados Maxime; DuBois Raymond N; Fitzgerald Garret A; Frishman W; García Rodríguez Luis A; Hochberg Marc C; Kalden Joachim R; Laine Loren; Langman Michael J S; Prescott Stephen M; van de Putte Leo B A; Whelton Andrew; White William B; Willaims Gordon H
Controversies in COX-2 selective inhibition.
The Journal of rheumatology 2002;29(7):1501-10.
2002: Dubois Raymond N
The evolution of modern academic medicine continues.
Gastroenterology 2002;122(7):1719.
2002: Shao Jinyi; Sheng Hongmiao; DuBois Raymond N
Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells.
Cancer research 2002;62(11):3282-8.
2002: Kozak Kevin R; Gupta Rajnish A; Moody John S; Ji Chuan; Boeglin William E; DuBois Raymond N; Brash Alan R; Marnett Lawrence J
15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
The Journal of biological chemistry 2002;277(26):23278-86.
2002: Hawk Ernest T; Viner Jaye L; Dannenberg Andrew; DuBois Raymond N
COX-2 in cancer--a player that's defining the rules.
Journal of the National Cancer Institute 2002;94(8):545-6.
2002: Gupta Rajnish A; DuBois Raymond N
Cyclooxygenase-2 inhibitor therapy for the prevention of esophageal adenocarcinoma in Barrett's esophagus.
Journal of the National Cancer Institute 2002;94(6):406-7.
2002: Turini Marco E; DuBois Raymond N
Cyclooxygenase-2: a therapeutic target.
Annual review of medicine 2002;53():35-57.
2002: Marnett Lawrence J; DuBois Raymond N
COX-2: a target for colon cancer prevention.
Annual review of pharmacology and toxicology 2002;42():55-80.
2001: Stack E; DuBois R N
Role of cyclooxygenase inhibitors for the prevention of colorectal cancer.
Gastroenterology clinics of North America 2001;30(4):1001-10.
2001: Reese J; Das S K; Paria B C; Lim H; Song H; Matsumoto H; Knudtson K L; DuBois R N; Dey S K
Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation.
The Journal of biological chemistry 2001;276(47):44137-45.
2001: Gupta R A; Dubois R N
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.
Nature reviews. Cancer 2001;1(1):11-21.
2001: Pyo H; Choy H; Amorino G P; Kim J S; Cao Q; Hercules S K; DuBois R N
A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):2998-3005.
2001: Stack E; DuBois R N
Regulation of cyclo-oxygenase-2.
Best practice & research. Clinical gastroenterology 2001;15(5):787-800.
2001: Williams C S; Sheng H; Brockman J A; Armandla R; Shao J; Washington M K; Elkahloun A G; DuBois R N
A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts.
Neoplasia (New York, N.Y.) 2001;3(5):428-36.
2001: Gupta R A; Polk D B; Krishna U; Israel D A; Yan F; DuBois R N; Peek R M
Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells.
The Journal of biological chemistry 2001;276(33):31059-66.
2001: Gupta R A; Brockman J A; Sarraf P; Willson T M; DuBois R N
Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells.
The Journal of biological chemistry 2001;276(32):29681-7.
2001: Zhang Z; DuBois R N
Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor.
Oncogene 2001;20(33):4450-6.
2001: Mann M; Sheng H; Shao J; Williams C S; Pisacane P I; Sliwkowski M X; DuBois R N
Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth.
Gastroenterology 2001;120(7):1713-9.
2001: Krause W F; DuBois R N
The molecular basis for prevention of colorectal cancer.
Clinical colorectal cancer 2001;1(1):47-54.
2001: DuBois R N
New paradigms for cancer prevention.
Carcinogenesis 2001;22(5):691-2.
2001: Souto E O; Miyoshi H; Dubois R N; Gores G J
Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G805-11.
2001: Sheng H; Shao J; Washington M K; DuBois R N
Prostaglandin E2 increases growth and motility of colorectal carcinoma cells.
The Journal of biological chemistry 2001;276(21):18075-81.
2001: Kandil H M; Tanner G; Smalley W; Halter S; Radhika A; Dubois R N
Cyclooxygenase-2 expression in Barrett's esophagus.
Digestive diseases and sciences 2001;46(4):785-9.
2001: Sheng H; Shao J; DuBois R N
Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells.
The Journal of biological chemistry 2001;276(17):14498-504.
2001: Sheng H; Shao J; Dubois R N
K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1.
Cancer research 2001;61(6):2670-5.
2001: Dubois R N
Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention.
Current opinion in gastroenterology 2001;17(1):65-71.
2001: Shappell S B; Gupta R A; Manning S; Whitehead R; Boeglin W E; Schneider C; Case T; Price J; Jack G S; Wheeler T M; Matusik R J; Brash A R; Dubois R N
15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.
Cancer research 2001;61(2):497-503.
2000: Zhang Z; Sheng H; Shao J; Beauchamp R D; DuBois R N
Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells.
Neoplasia (New York, N.Y.) 2000;2(6):523-30.
2000: Tong B J; Tan J; Tajeda L; Das S K; Chapman J A; DuBois R N; Dey S K
Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma.
Neoplasia (New York, N.Y.) 2000;2(6):483-90.
2000: Gupta R A; Tan J; Krause W F; Geraci M W; Willson T M; Dey S K; DuBois R N
Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13275-80.
2000: Williams C S; Watson A J; Sheng H; Helou R; Shao J; DuBois R N
Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models.
Cancer research 2000;60(21):6045-51.
2000: Shao J; Sheng H; Inoue H; Morrow J D; DuBois R N
Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells.
The Journal of biological chemistry 2000;275(43):33951-6.
2000: Shao J; Sheng H; DuBois R N; Beauchamp R D
Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.
The Journal of biological chemistry 2000;275(30):22916-24.
2000: Gupta R A; DuBois R N
Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer.
Annals of the New York Academy of Sciences 2000;910():196-204; discussion 204-6.
2000: Williams C S; Tsujii M; Reese J; Dey S K; DuBois R N
Host cyclooxygenase-2 modulates carcinoma growth.
The Journal of clinical investigation 2000;105(11):1589-94.
2000: Zhang Z; DuBois R N
Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Gastroenterology 2000;118(6):1012-7.
2000: Krause W; DuBois R N
Eicosanoids and the large intestine.
Prostaglandins & other lipid mediators 2000;61(3-4):145-61.
2000: Dubois R N
Review article: cyclooxygenase--a target for colon cancer prevention.
Alimentary pharmacology & therapeutics 2000;14 Suppl 1():64-7.
2000: Sheng H; Shao J; Dixon D A; Williams C S; Prescott S M; DuBois R N; Beauchamp R D
Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.
The Journal of biological chemistry 2000;275(9):6628-35.
2000: Shattuck-Brandt R L; Varilek G W; Radhika A; Yang F; Washington M K; DuBois R N
Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice.
Gastroenterology 2000;118(2):337-45.
1999: Williams C S; Mann M; DuBois R N
The role of cyclooxygenases in inflammation, cancer, and development.
Oncogene 1999;18(55):7908-16.
1999: DuBOIS R N
COX-2 in large bowel cancer: a one-sided story.
Gut 1999;45(5):636-7.
1999: O'Mahony C A; Beauchamp R D; Albo D; Tsujii M; Sheng H M; Shao J; Dubois R N; Berger D H
Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis.
Surgery 1999;126(2):364-70.
1999: Williams C S; Goldman A P; Sheng H; Morrow J D; DuBois R N
Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth.
Neoplasia (New York, N.Y.) 1999;1(2):170-6.
1999: Lim H; Gupta R A; Ma W G; Paria B C; Moller D E; Morrow J D; DuBois R N; Trzaskos J M; Dey S K
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.
Genes & development 1999;13(12):1561-74.
1999: Shattuck-Brandt R L; Lamps L W; Heppner Goss K J; DuBois R N; Matrisian L M
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.
Molecular carcinogenesis 1999;24(3):177-87.
1999: Shao J; Sheng H; Aramandla R; Pereira M A; Lubet R A; Hawk E; Grogan L; Kirsch I R; Washington M K; Beauchamp R D; DuBois R N
Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors.
Carcinogenesis 1999;20(2):185-91.
1999: Shattuck-Brandt R L; DuBois R N
The molecular basis of colorectal carcinogenesis.
Current opinion in gastroenterology 1999;15(1):3-8.
1999: Williams C S; Shattuck-Brandt R L; DuBois R N
The role of COX-2 in intestinal cancer.
Expert opinion on investigational drugs 1999;8(1):1-12.
1999: Sheng H; Shao J; O'Mahony C A; Lamps L; Albo D; Isakson P C; Berger D H; DuBois R N; Beauchamp R D
Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2.
Oncogene 1999;18(4):855-67.
1999: Williams C; Shattuck-Brandt R L; DuBois R N
The role of COX-2 in intestinal cancer.
Annals of the New York Academy of Sciences 1999;889():72-83.
1998: Goldman A P; Williams C S; Sheng H; Lamps L W; Williams V P; Pairet M; Morrow J D; DuBois R N
Meloxicam inhibits the growth of colorectal cancer cells.
Carcinogenesis 1998;19(12):2195-9.
1998: Lipsky L P; Abramson S B; Crofford L; Dubois R N; Simon L S; van de Putte L B
The classification of cyclooxygenase inhibitors.
The Journal of rheumatology 1998;25(12):2298-303.
1998: Brockman J A; Gupta R A; Dubois R N
Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells.
Gastroenterology 1998;115(5):1049-55.
1998: Dubois R N; Abramson S B; Crofford L; Gupta R A; Simon L S; Van De Putte L B; Lipsky P E
Cyclooxygenase in biology and disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1063-73.
1998: Sheng H; Williams C S; Shao J; Liang P; DuBois R N; Beauchamp R D
Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway.
The Journal of biological chemistry 1998;273(34):22120-7.
1998: Tsujii M; Kawano S; Tsuji S; Sawaoka H; Hori M; DuBois R N
Cyclooxygenase regulates angiogenesis induced by colon cancer cells.
Cell 1998;93(5):705-16.
1998: Gupta R A; DuBois R N
Aspirin, NSAIDS, and colon cancer prevention: mechanisms?
Gastroenterology 1998;114(5):1095-8.
1998: Sheng H; Shao J; Williams C S; Pereira M A; Taketo M M; Oshima M; Reynolds A B; Washington M K; DuBois R N; Beauchamp R D
Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas.
Carcinogenesis 1998;19(4):543-9.
1998: DuBois R N; Gupta R; Brockman J; Reddy B S; Krakow S L; Lazar M A
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers.
Carcinogenesis 1998;19(1):49-53.
1998: Sheng H; Shao J; Morrow J D; Beauchamp R D; DuBois R N
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
Cancer research 1998;58(2):362-6.
1997: Sheng G G; Shao J; Sheng H; Hooton E B; Isakson P C; Morrow J D; Coffey R J; DuBois R N; Beauchamp R D
A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells.
Gastroenterology 1997;113(6):1883-91.
1997: Williams C S; Smalley W; DuBois R N
Aspirin use and potential mechanisms for colorectal cancer prevention.
The Journal of clinical investigation 1997;100(6):1325-9.
1997: Sheng H; Shao J; Kirkland S C; Isakson P; Coffey R J; Morrow J; Beauchamp R D; DuBois R N
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.
The Journal of clinical investigation 1997;99(9):2254-9.
1997: Zhang T; Nanney L B; Peeler M O; Williams C S; Lamps L; Heppner K J; DuBois R N; Beauchamp R D
Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression.
Cancer research 1997;57(9):1638-43.
1997: Sheng H; Shao J; Hooton E B; Tsujii M; DuBois R N; Beauchamp R D
Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(4):463-70.
1997: Tsujii M; Kawano S; DuBois R N
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3336-40.
1997: Coffey R J; Hawkey C J; Damstrup L; Graves-Deal R; Daniel V C; Dempsey P J; Chinery R; Kirkland S C; DuBois R N; Jetton T L; Morrow J D
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):657-62.
1997: Zhang T; Nanney L B; Luongo C; Lamps L; Heppner K J; DuBois R N; Beauchamp R D
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.
Cancer research 1997;57(1):169-75.
1997: Smalley W E; DuBois R N
Colorectal cancer and nonsteroidal anti-inflammatory drugs.
Advances in pharmacology (San Diego, Calif.) 1997;39():1-20.
1996: Williams C S; Luongo C; Radhika A; Zhang T; Lamps L W; Nanney L B; Beauchamp R D; DuBois R N
Elevated cyclooxygenase-2 levels in Min mouse adenomas.
Gastroenterology 1996;111(4):1134-40.
1996: DuBois R N; Eberhart C F; Williams C S
Introduction to eicosanoids and the gastroenteric tract.
Gastroenterology clinics of North America 1996;25(2):267-77.
1996: DuBois R N; Radhika A; Reddy B S; Entingh A J
Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors.
Gastroenterology 1996;110(4):1259-62.
1996: Williams C S; DuBois R N
Prostaglandin endoperoxide synthase: why two isoforms?
The American journal of physiology 1996;270(3 Pt 1):G393-400.
1996: DuBois R N; Shao J; Tsujii M; Sheng H; Beauchamp R D
G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2.
Cancer research 1996;56(4):733-7.
1995: Tsujii M; DuBois R N
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.
Cell 1995;83(3):493-501.
1995: Zeldin D C; DuBois R N; Falck J R; Capdevila J H
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Archives of biochemistry and biophysics 1995;322(1):76-86.
1995: Eberhart C E; Dubois R N
Eicosanoids and the gastrointestinal tract.
Gastroenterology 1995;109(1):285-301.
1995: DuBois R N; Bishop P R; Graves-Deal R; Coffey R J
Transforming growth factor alpha regulation of two zinc finger-containing immediate early response genes in intestine.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(5):523-9.
1995: Capdevila J H; Morrow J D; Belosludtsev Y Y; Beauchamp D R; DuBois R N; Falck J R
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).
Biochemistry 1995;34(10):3325-37.
1995: Barnard J A; Beauchamp R D; Russell W E; Dubois R N; Coffey R J
Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology.
Gastroenterology 1995;108(2):564-80.
1994: Harris R C; McKanna J A; Akai Y; Jacobson H R; Dubois R N; Breyer M D
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
The Journal of clinical investigation 1994;94(6):2504-10.
1994: Eberhart C E; Coffey R J; Radhika A; Giardiello F M; Ferrenbach S; DuBois R N
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.
Gastroenterology 1994;107(4):1183-8.
1994: DuBois R N; Tsujii M; Bishop P; Awad J A; Makita K; Lanahan A
Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells.
The American journal of physiology 1994;266(5 Pt 1):G822-7.
1994: DuBois R N; Awad J; Morrow J; Roberts L J; Bishop P R
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.
The Journal of clinical investigation 1994;93(2):493-8.
1993: Karara A; Makita K; Jacobson H R; Falck J R; Guengerich F P; DuBois R N; Capdevila J H
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.
The Journal of biological chemistry 1993;268(18):13565-70.
1992: Capdevila J H; Wei S; Yan J; Karara A; Jacobson H R; Falck J R; Guengerich F P; DuBois R N
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
The Journal of biological chemistry 1992;267(30):21720-6.

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