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Juan Dubrot

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Publications

TOP 3
José I Quetglas; Miguel F Sanmamed; Cristian Smerdou; Jaione Bezunartea; Juan Dubrot; Sandra Hervas-Stubbs; Ignacio Melero
Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12.
Maria C Ochoa; Asis Palazon; Jesus Prieto; Aizea Morales-Kastresana; Oihana Murillo; Carlos Alfaro; Ainhoa Arina; Pedro Berraondo; Juan Dubrot; Erwin H Duitman; Jessica Fioravanti; Sandra Hervas-Stubbs; Jose Medina-Echeverz; Ignacio Melero
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.
Natalia Suarez; Aizea Morales-Kastresana; Asis Palazon; Jose Luis Perez-Gracia; Bruno Sangro; Carlos Alfaro; Elixabet Bolaños; Juan Dubrot; Lorena Erro; Alvaro Gonzalez; Sandra Hervas-Stubbs; Fernando Lecanda; Salvador Martin-Algarra; Ivan Martinez-Forero; Ignacio Melero
Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo.

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All Publications

2012: José I Quetglas; Miguel F Sanmamed; Cristian Smerdou; Jaione Bezunartea; Juan Dubrot; Sandra Hervas-Stubbs; Ignacio Melero
Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(9):1664-75.
2012: Maria C Ochoa; Asis Palazon; Jesus Prieto; Aizea Morales-Kastresana; Oihana Murillo; Carlos Alfaro; Ainhoa Arina; Pedro Berraondo; Juan Dubrot; Erwin H Duitman; Jessica Fioravanti; Sandra Hervas-Stubbs; Jose Medina-Echeverz; Ignacio Melero
Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.
PloS one 2012;7(12):e52370.
2011: Natalia Suarez; Aizea Morales-Kastresana; Asis Palazon; Jose Luis Perez-Gracia; Bruno Sangro; Carlos Alfaro; Elixabet Bolaños; Juan Dubrot; Lorena Erro; Alvaro Gonzalez; Sandra Hervas-Stubbs; Fernando Lecanda; Salvador Martin-Algarra; Ivan Martinez-Forero; Ignacio Melero
Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo.
International journal of cancer. Journal international du cancer 2011;129(2):374-86.
2011: Asís Palazón; Alvaro Teijeira; Iván Martínez-Forero; Sandra Hervás-Stubbs; Carmen Roncal; Iván Peñuelas; Juan Dubrot; Aizea Morales-Kastresana; José Luis Pérez-Gracia; M Carmen Ochoa; Laura Ochoa; Alfredo Martínez; Alfonso Luque; Joseph Dinchuk; Ana Rouzaut; Maria Jure-Kunkel; Ignacio Melero
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.
Cancer research 2011;71(3):801-11.
2011: Carlos Alfaro; Natalia Suárez; Ivan Martínez-Forero; Asís Palazón; Ana Rouzaut; Sarai Solano; Esperanza Feijoo; Alfonso Gúrpide; Elixabet Bolaños; Lorena Erro; Juan Dubrot; Sandra Hervás-Stubbs; Alvaro Gonzalez; Jose Luis Perez-Gracia; Ignacio Melero
Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.
PloS one 2011;6(3):e17922.
2011: Juan Dubrot; Asis Palazón; Carlos Alfaro; Arantza Azpilikueta; María Carmen Ochoa; Ana Rouzaut; Iván Martinez-Forero; Alvaro Teijeira; Pedro Berraondo; Agnes Le Bon; Sandra Hervás-Stubbs; Ignacio Melero
Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.
International journal of cancer. Journal international du cancer 2011;128(1):105-18.
2010: Sandra Hervas-Stubbs; José I Riezu-Boj; Iranzu Gonzalez; Uxua Mancheño; Juan Dubrot; Arantza Azpilicueta; Izaskun Gabari; Asis Palazon; Alicia Aranguren; Juan Ruiz; Jesus Prieto; Esther Larrea; Ignacio Melero
Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells.
European journal of immunology 2010;40(12):3389-402.
2010: Ana Rouzaut; Saray Garasa; Alvaro Teijeira; Iranzu González; Ivan Martinez-Forero; Natalia Suarez; Esther Larrea; Carlos Alfaro; Asís Palazón; Juan Dubrot; Sandra Hervás-Stubbs; Ignacio Melero
Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α.
European journal of immunology 2010;40(11):3054-63.
2010: Juan Dubrot; Aitziber Portero; Gorka Orive; Rosa María Hernández; Asis Palazón; Ana Rouzaut; Jose L Perez-Gracia; Sandra Hervás-Stubbs; Jose Luis Pedraz; Ignacio Melero
Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells.
Cancer immunology, immunotherapy : CII 2010;59(11):1621-31.
2010: Juan Dubrot; Francisca Milheiro; Carlos Alfaro; Asis Palazón; Ivan Martinez-Forero; Jose L Perez-Gracia; Aizea Morales-Kastresana; José L Romero-Trevejo; María C Ochoa; Sandra Hervás-Stubbs; Jesús Prieto; Maria Jure-Kunkel; Lieping Chen; Ignacio Melero
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Cancer immunology, immunotherapy : CII 2010;59(8):1223-33.
2010: Antonio Fontanellas; Sandra Hervás-Stubbs; Itsaso Mauleón; Juan Dubrot; Uxua Mancheño; María Collantes; Ana Sampedro; Carmen Unzu; Carlos Alfaro; Asis Palazón; Cristian Smerdou; Alberto Benito; Jesús Prieto; Iván Peñuelas; Ignacio Melero
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(4):754-65.
2010: Carmen Unzu; Ana Sampedro; Itsaso Mauleón; Lucía Vanrell; Juan Dubrot; Rafael Enríquez de Salamanca; Gloria González-Aseguinolaza; Ignacio Melero; Jesús Prieto; Antonio Fontanellas
Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria.
Journal of hepatology 2010;52(3):417-24.
2009: Ivan Martinez-Forero; Ana Rouzaut; Asis Palazon; Juan Dubrot; Ignacio Melero
Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6751-7.
2009: Oihana Murillo; Juan Dubrot; Asís Palazón; Ainhoa Arina; Arantza Azpilikueta; Carlos Alfaro; Sarai Solano; María C Ochoa; Carmen Berasain; Izaskun Gabari; Jose L Pérez-Gracia; Pedro Berraondo; Sandra Hervás-Stubbs; Ignacio Melero
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.
European journal of immunology 2009;39(9):2424-36.
2009: Carlos Alfaro; N Suarez; A Gonzalez; S Solano; L Erro; Juan Dubrot; A Palazon; Sandra Hervas-Stubbs; Alfonso Gurpide; Jose Maria Lopez-Picazo; E Grande-Pulido; I Melero; J L Perez-Gracia
Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes.
British journal of cancer 2009;100(7):1111-9.
2009: Ignacio Melero; Ivan Martinez-Forero; Juan Dubrot; Natalia Suarez; Asis Palazón; Lieping Chen
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1507-9.
2008: Oihana Murillo; Ainhoa Arina; Sandra Hervas-Stubbs; Anjana Gupta; Brandon McCluskey; Juan Dubrot; Asís Palazón; Arantza Azpilikueta; Maria C Ochoa; Carlos Alfaro; Sarai Solano; José L Pérez-Gracia; Babatunde Oyajobi; Ignacio Melero
Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6895-906.
2008: Ignacio Melero; Oihana Murillo; Juan Dubrot; Sandra Hervás-Stubbs; José L Perez-Gracia
Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.
Trends in pharmacological sciences 2008;29(8):383-90.
2008: Ainhoa Arina; Oihana Murillo; Juan Dubrot; A Azpilikueta; Izaskun Gabari; J L Perez-Gracia; Carlos Alfaro; Carmen Berasain; Jesús Prieto; S Ferrini; Sandra Hervas-Stubbs; Ignacio Melero
Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.
Gene therapy 2008;15(7):473-83.
2007: Guillermo Mazzolini; Oihana Murillo; Catalina Atorrasagasti; Juan Dubrot; Iñigo Tirapu; Miguel Rizzo; Ainhoa Arina; Carlos Alfaro; Arantza Azpilicueta; Carmen Berasain; José L Perez-Gracia; Alvaro Gonzalez; Ignacio Melero
Immunotherapy and immunoescape in colorectal cancer.
World journal of gastroenterology : WJG 2007;13(44):5822-31.
2007: Ainhoa Arina; Oihana Murillo; Sandra Hervás-Stubbs; Arantza Azpilikueta; Juan Dubrot; Iñigo Tirapu; Eduardo Huarte; Carlos Alfaro; Jose L Pérez-Gracia; Gloria González-Aseguinolaza; Pablo Sarobe; Juan José Lasarte; Amanda Jamieson; Jesús Prieto; David H Raulet; Ignacio Melero
The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.
International journal of cancer. Journal international du cancer 2007;121(6):1282-95.
2007: Ainhoa Arina; Oihana Murillo; Juan Dubrot; Arantza Azpilikueta; Carlos Alfaro; Jose L Pérez-Gracia; Maurizio Bendandi; Belen Palencia; Sandra Hervás-Stubbs; Ignacio Melero
Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer.
Expert opinion on biological therapy 2007;7(5):599-615.
2006: Ignacio Melero; Ainhoa Arina; Oihana Murillo; Juan Dubrot; Carlos Alfaro; Jose L Pérez-Gracia; Maurizio Bendandi; Sandra Hervás-Stubbs
Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2385-9.