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Subramaniam Ananthan

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Dong-Hoon Chung; Jennifer E Golden; Fuli Jia; Colleen B Jonsson; Clinton Maddox; Daljit S Matharu; Blake P Moore; Lynn Rasmussen; Melinda I Sosa; E Lucile White; Subramaniam Ananthan; William Severson
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.
Blake P Moore; James W Noah; Thomas E Prisinzano; Lynn Rasmussen; Melinda I Sosa; Nichole A Tower; E Lucile White; Subramaniam Ananthan; Jeffrey Aubé; Dong Hoon Chung; Jennifer E Golden; Fuli Jia; Colleen B Jonsson; Clinton Maddox; Daljit S Matharu; William Severson
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.
Subramaniam Ananthan; Edward J Bilsky; Christina M Dersch; Denise Giuvelis; Nicholas McGlinchey; Surendra K Saini; Heng Xu; Richard B Rothman
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.

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All Publications

2013: Dong-Hoon Chung; Jennifer E Golden; Fuli Jia; Colleen B Jonsson; Clinton Maddox; Daljit S Matharu; Blake P Moore; Lynn Rasmussen; Melinda I Sosa; E Lucile White; Subramaniam Ananthan; William Severson
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.
Virology journal 2013;10():19.
2012: Blake P Moore; James W Noah; Thomas E Prisinzano; Lynn Rasmussen; Melinda I Sosa; Nichole A Tower; E Lucile White; Subramaniam Ananthan; Jeffrey Aubé; Dong Hoon Chung; Jennifer E Golden; Fuli Jia; Colleen B Jonsson; Clinton Maddox; Daljit S Matharu; William Severson
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.
Journal of medicinal chemistry 2012;55(20):8582-7.
2012: Subramaniam Ananthan; Edward J Bilsky; Christina M Dersch; Denise Giuvelis; Nicholas McGlinchey; Surendra K Saini; Heng Xu; Richard B Rothman
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.
Journal of medicinal chemistry 2012;55(19):8350-63.
2012: Frank Bennett; Robert Chase; Jeremy L Clark; Stephanie Curry; Anita T Fowler; Feng Geng; F George Njoroge; Viyyoor Girijavallabhan; Hsueh-Cheng Huang; Yuhua Huang; Regina Huelgas; Hollis S Kezar; Cecil D Kwong; Cheng Li; Malcolm MacCoss; Joseph A Maddry; John J Piwinski; Robert C Reynolds; RR Rossman; Abhijit Roychowdhury; John A Secrist; Neng-Yang Shih; Xiao Tong; Subramaniam Ananthan; Ashok Arasappan
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(15):5144-9.
2012: Carsten Nielsen; Jeffrey A Simms; Subramaniam Ananthan; Jade J Bito-Onon; Rui Li; Selena Bartlett
The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking.
Addiction biology 2012;17(2):224-34.
2012: Sandlin P Seguin; Melinda Sosa; Nichole A Tower; E Lucile White; Lynn Rasmussen; Subramaniam Ananthan; Jeffrey Aubé; Jeffrey L Brodsky; Carrie W Evans; Jennifer E Golden; Brooks E Maki; Daljit S Matharu; Sara McKellip; Miranda Nebane-Akah; James W Noah
High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity.
Journal of biomolecular screening 2012;17(2):194-203.
2012: Robert C Reynolds; Subramaniam Ananthan; Ellen Faaleolea; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Melinda I Sosa; Elizabeth Thammasuvimol; E Lucile White; Wei Zhang; John A Secrist
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.
Tuberculosis (Edinburgh, Scotland) 2012;92(1):72-83.
2011: Jun Zhu; Charles F Mactutus; Subramaniam Ananthan; Rosemarie M Booze
Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.
Synapse (New York, N.Y.) 2011;65(11):1251-4.
2011: Joseph A Maddry; Xi Chen; Colleen B Jonsson; Subramaniam Ananthan; Judith Hobrath; Donald F Smee; James W Noah; Diana Noah; Xiaolin Xu; Fuli Jia; Clinton Maddox; Melinda I Sosa; E Lucile White; William Severson
Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen.
Journal of biomolecular screening 2011;16(1):73-81.
2011: Marina S Manuvakhova; Guyla G Johnson; Misti C White; Subramaniam Ananthan; Melinda Sosa; Clinton Maddox; Sara McKellip; Lynn Rasmussen; Krister Wennerberg; Judith V Hobrath; E Lucile White; Joseph A Maddry; Maurizio Grimaldi
Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.
Journal of neuroscience research 2011;89(1):58-72.
2010: Lisha Zhang; N Miranda Nebane; Krister Wennerberg; Yujie Li; Valerie Neubauer; Judith V Hobrath; Sara McKellip; Lynn Rasmussen; Nice Shindo; Melinda Sosa; Joseph A Maddry; Subramaniam Ananthan; Gary A Piazza; E Lucile White; Edina Harsay
A high-throughput screen for chemical inhibitors of exocytic transport in yeast.
Chembiochem : a European journal of chemical biology 2010;11(9):1291-301.
2010: Dong Hoon Chung; Colleen B Jonsson; Clinton Maddox; Sara N McKellip; Blake P Moore; Marintha Heil; E Lucile White; Subramaniam Ananthan; Qianjun Li; Shuang Feng; Lynn Rasmussen
HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity.
Molecules (Basel, Switzerland) 2010;15(3):1690-704.
2009: Joseph A Maddry; Subramaniam Ananthan; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Melinda I Sosa; E Lucile White; Wei Zhang
Antituberculosis activity of the molecular libraries screening center network library.
Tuberculosis (Edinburgh, Scotland) 2009;89(5):354-63.
2009: Subramaniam Ananthan; Ellen R Faaleolea; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Barbara E Laughon; Joseph A Maddry; Alka Mehta; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Nice Shindo; Dustin N Showe; Melinda I Sosa; William J Suling; E Lucile White
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.
Tuberculosis (Edinburgh, Scotland) 2009;89(5):334-53.
2009: Richard B Rothman; Christina M Dersch; Subramaniam Ananthan; John S Partilla
Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release.
The Journal of pharmacology and experimental therapeutics 2009;329(2):718-28.
2009: Subramaniam Ananthan; Wei Zhang; Judith Varady Hobrath
Recent advances in structure-based virtual screening of G-protein coupled receptors.
The AAPS journal 2009;11(1):178-85.
2008: Carsten Nielsen; Jeffrey A Simms; Haley B Pierson; Rui Li; Surendra K Saini; Subramaniam Ananthan; Selena Bartlett
A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats.
Biological psychiatry 2008;64(11):974-81.
2008: William Severson; Michael McDowell; Subramaniam Ananthan; Dong-Hoon Chung; Lynn Rasmussen; Melinda I Sosa; E Lucile White; James Noah; Colleen B Jonsson
High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).
Journal of biomolecular screening 2008;13(9):879-87.
2008: Joseph J Pariser; John S Partilla; Christina M Dersch; Subramaniam Ananthan; Richard B Rothman
Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release.
The Journal of pharmacology and experimental therapeutics 2008;326(1):286-95.
2007: William Severson; Nice Shindo; Mindy Sosa; Thomas Fletcher; E Lucile White; Subramaniam Ananthan; Colleen B Jonsson
Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library.
Journal of biomolecular screening 2007;12(1):33-40.
2006: Subramaniam Ananthan
Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics.
The AAPS journal 2006;8(1):E118-25.
2005: Diana Caballero-Hernández; Richard J. Weber; Mary E Hicks; Reyes S Tamez-Guerra; Cristina Rodríguez Padilla; Patricia Tamez-Guerra; Kenner C Rice; Subramaniam Ananthan; ricardo gomez
Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids.
International immunopharmacology 2005;5(7-8):1271-8.
2004: Ayon Nandi; Christina M Dersch; Manish Kulshrestha; Subramaniam Ananthan; Richard B Rothman
Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter.
Synapse (New York, N.Y.) 2004;53(3):176-83.
2004: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Lainne E Seitz; Jeffrey L Bartlett; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman; Edward J Bilsky
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Journal of medicinal chemistry 2004;47(6):1400-12.
2003: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry 2003;11(18):4143-54.
2003: Subramaniam Ananthan; Hollis S Kezar; Surendra K Saini; Naveen K Khare; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry letters 2003;13(3):529-32.
2002: Subramaniam Ananthan; Surendra K Saini; Rashmi Khare; Sarah D Clayton; Christina M Dersch; Richard B Rothman
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.
Bioorganic & medicinal chemistry letters 2002;12(16):2225-8.
2002: Richard B Rothman; Christina M Dersch; Frank carroll; Subramaniam Ananthan
Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
Synapse (New York, N.Y.) 2002;43(4):268-74.
2001: Heng Xu; Yi-Feng Lu; Kenner C Rice; Subramaniam Ananthan; Richard B Rothman
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Brain research bulletin 2001;55(4):507-11.
2001: J L Wells; J L Bartlett; Subramaniam Ananthan; Edward J Bilsky
In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.
The Journal of pharmacology and experimental therapeutics 2001;297(2):597-605.
1999: Subramaniam Ananthan; Hollis S Kezar; R L Carter; Surendra K Saini; Kenner C Rice; J L Wells; Peg Davis; Heng Xu; Christina M Dersch; Edward J Bilsky; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Journal of medicinal chemistry 1999;42(18):3527-38.
1998: Subramaniam Ananthan; Cheryl A Johnson; R L Carter; S D Clayton; Kenner C Rice; Heng Xu; Peg Davis; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Journal of medicinal chemistry 1998;41(15):2872-81.
1998: M E Riley; Subramaniam Ananthan; Richard J. Weber
Novel non-peptidic opioid compounds with immunopotentiating effects.
Advances in experimental medicine and biology 1998;437():183-7.
1998: Heng Xu; Yi-Feng Lu; John S Partilla; J Pinto; S N Calderon; Dorota Matecka; Kenner C Rice; J Lai; Frank Porreca; Subramaniam Ananthan; Richard B Rothman
Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.
Peptides 1998;19(2):343-50.
1993: M D Erion; S Niwas; J D Rose; Subramaniam Ananthan; M Allen; John A Secrist; Yarlagadda S Babu; C E Bugg; W C Guida; Steven E Ealick
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Journal of medicinal chemistry 1993;36(24):3771-83.
1993: Subramaniam Ananthan; S D Clayton; Steven E Ealick; G Wong; G E Evoniuk; P Skolnick
Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.
Journal of medicinal chemistry 1993;36(4):479-90.