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Vellareddy Anantharam

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Anumantha G Kanthasamy; Vellareddy Anantharam; C Choi; D S Harischandra; H Jin; A Kanthasamy
Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.
Anumantha Kanthasamy; Ajay Rana; Velusamy Rangasamy; Gautam Sondarva; Vellareddy Anantharam; Huajun Jin; Arthi Kanthasamy
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.
M Lin; Anumantha G Kanthasamy; S Ali; Vellareddy Anantharam; P Chandramani-Shivalingappa; A Ghosh; H Jin; PRASHANTH CHANDRAMANI SHIVALINGAPPA
Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells.

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All Publications

2012: Anumantha G Kanthasamy; Vellareddy Anantharam; C Choi; D S Harischandra; H Jin; A Kanthasamy
Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.
Toxicology letters 2012;214(3):288-95.
2012: Anumantha Kanthasamy; Ajay Rana; Velusamy Rangasamy; Gautam Sondarva; Vellareddy Anantharam; Huajun Jin; Arthi Kanthasamy
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.
Neurotoxicology 2012;33(4):833-7.
2012: M Lin; Anumantha G Kanthasamy; S Ali; Vellareddy Anantharam; P Chandramani-Shivalingappa; A Ghosh; H Jin; PRASHANTH CHANDRAMANI SHIVALINGAPPA
Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells.
Neuroscience 2012;210():308-32.
2012: Anamitra Ghosh; Joy Joseph; Balaraman Kalyanaraman; Arthi Kanthasamy; Vellareddy Anantharam; Brian P Dranka; Pallavi Srivastava; Anumantha G Kanthasamy
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.
Journal of neuroinflammation 2012;9():241.
2012: Prashanth Chandramani Shivalingappa; Huajun Jin; PRASHANTH CHANDRAMANI SHIVALINGAPPA; Vellareddy Anantharam; Arthi Kanthasamy
N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells.
Parkinson's disease 2012;2012():424285.
2012: Richard Gordon; Vellareddy Anantharam; Anumantha G Kanthasamy; Arthi Kanthasamy
Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation.
Journal of neuroinflammation 2012;9():82.
2011: Hilary Afeseh Ngwa; Vellareddy Anantharam; Ning Fang; Yan Gu; Arthi Kanthasamy; Anumantha G Kanthasamy
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.
Toxicology and applied pharmacology 2011;256(3):227-40.
2011: Calivarathan Latchoumycandane, Ph.D., DABT.,; Vellareddy Anantharam; Huajun Jin; Anumantha G Kanthasamy; Arthi Kanthasamy
Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease.
Toxicology and applied pharmacology 2011;256(3):314-23.
2011: Dustin P Martin; Travis Witte; Vellareddy Anantharam; Robert Houk; Huajun Jin; Arthi Kanthasamy; Anumantha G Kanthasamy
Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.
Neurotoxicology 2011;32(5):554-62.
2011: Hariharan Saminathan; Anumantha G Kanthasamy; Vellareddy Anantharam; Arunkumar Asaithambi; Arthi Kanthasamy
Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.
Neurotoxicology 2011;32(5):567-77.
2011: C Song; Vellareddy Anantharam; H Jin; A Kanthasamy; Anumantha G Kanthasamy
Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration.
Neurotoxicology 2011;32(5):586-95.
2011: Danhui Zhang; Arthi Kanthasamy; Vellareddy Anantharam; Anumantha Kanthasamy
Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line.
Toxicology and applied pharmacology 2011;254(2):65-71.
2011: Huajun Jin; Arthi Kanthasamy; Vellareddy Anantharam; Ajay Rana; Anumantha G Kanthasamy
Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.
The Journal of biological chemistry 2011;286(22):19840-59.
2011: Kavin Kanthasamy; Anumantha G Kanthasamy; Syed Ali; Vellareddy Anantharam; Richard Gordon; Huajun Jin; Arthi Kanthasamy
Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity.
Current neuropharmacology 2011;9(1):49-53.
2011: Huajun Jin; Arthi Kanthasamy; Anamitra Ghosh; Yongjie Yang; Vellareddy Anantharam; Anumantha G Kanthasamy
α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(6):2035-51.
2011: Richard Gordon; Colleen E Hogan; Matthew L Neal; Vellareddy Anantharam; Anumantha G Kanthasamy; Arthi Kanthasamy
A simple magnetic separation method for high-yield isolation of pure primary microglia.
Journal of neuroscience methods 2011;194(2):287-96.
2011: Arunkumar Asaithambi; Arthi Kanthasamy; Vellareddy Anantharam; Hariharan Saminathan; Anumantha G Kanthasamy
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration.
Molecular neurodegeneration 2011;6():43.
2010: Christopher J Choi; Vellareddy Anantharam; Dustin P Martin; Eric M Nicholson; Jürgen A Richt; Arthi Kanthasamy; Anumantha G Kanthasamy
Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(2):535-46.
2009: Miguel A Ortiz-Ortiz; José M Morán; Jose M Bravosanpedro; Rosa A González-Polo; Mireia Niso-Santano; Vellareddy Anantharam; Anumantha G Kanthasamy; Germán Soler; José M Fuentes
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Neurotoxicology 2009;30(6):1008-18.
2009: Hilary Afeseh Ngwa; Arthi Kanthasamy; Vellareddy Anantharam; Chunjuan Song; Travis Witte; Robert Houk; Anumantha G Kanthasamy
Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.
Toxicology and applied pharmacology 2009;240(2):273-85.
2009: Faneng Sun; Arthi Kanthasamy; Vellareddy Anantharam; Anumantha G Kanthasamy
Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63.
Journal of cellular and molecular medicine 2009;13(8B):1632-43.
2008: Vellareddy Anantharam; Arthi Kanthasamy; Christopher J Choi; Dustin P Martin; Calivarathan Latchoumycandane, Ph.D., DABT.,; Jüergen A Richt; Anumantha G Kanthasamy
Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.
Free radical biology & medicine 2008;45(11):1530-41.
2008: Faneng Sun; Arthi Kanthasamy; Chunjuan Song; Yongjie Yang; Vellareddy Anantharam; Anumantha G Kanthasamy
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.
Journal of cellular and molecular medicine 2008;12(6A):2467-81.
2008: Martha Carvour; Chunjuan Song; Siddharth Kaul; Vellareddy Anantharam; Anumantha G Kanthasamy; Arthi Kanthasamy
Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration.
Annals of the New York Academy of Sciences 2008;1139():197-205.
2008: Anumantha G Kanthasamy; Masashi Kitazawa; Yongjie Yang; Vellareddy Anantharam; Arthi Kanthasamy
Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease.
Molecular brain 2008;1():12.
2007: Vellareddy Anantharam; Siddharth Kaul; Chunjuan Song; Arthi Kanthasamy; Anumantha G Kanthasamy
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.
Neurotoxicology 2007;28(5):988-97.
2007: Danhui Zhang; Vellareddy Anantharam; Anumantha G Kanthasamy; Anumantha G Kanthasamy
Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics 2007;322(3):913-22.
2007: Christopher J Choi; Vellareddy Anantharam; Nathan J Saetveit; Robert S Houk; Arthi Kanthasamy; Anumantha G Kanthasamy
Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):495-509.
2007: Faneng Sun; Arthi Kanthasamy; Vellareddy Anantharam; Anumantha G Kanthasamy
Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.
Pharmacology & therapeutics 2007;114(3):327-44.
2007: Danhui Zhang; Anumantha G Kanthasamy; Yongjie Yang; Vellareddy Anantharam; Anumantha Kanthasamy
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(20):5349-62.
2007: Vellareddy Anantharam; Elin Lehrmann; Arthi Kanthasamy; Yongjie Yang; Probal Banerjee; Kevin G Becker; William J Freed; Anumantha G Kanthasamy
Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease.
Neurochemistry international 2007;50(6):834-47.
2006: Anumantha G Kanthasamy; Vellareddy Anantharam; Danhui Zhang; Calivarathan Latchoumycandane, Ph.D., DABT.,; Huajun Jin; Siddharth Kaul; Anumantha G Kanthasamy
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.
Free radical biology & medicine 2006;41(10):1578-89.
2006: Faneng Sun; Vellareddy Anantharam; Danhui Zhang; Calivarathan Latchoumycandane, Ph.D., DABT.,; Arthi Kanthasamy; Anumantha G Kanthasamy
Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.
Neurotoxicology 2006;27(5):807-15.
2006: Christopher J Choi; Anumantha G Kanthasamy; Vellareddy Anantharam; Anumantha G Kanthasamy
Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases.
Neurotoxicology 2006;27(5):777-87.
2006: Arthi Kanthasamy; Vellareddy Anantharam; Syed F Ali; Anumantha G Kanthasamy
Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death.
Annals of the New York Academy of Sciences 2006;1074():234-44.
2005: Faneng Sun; Vellareddy Anantharam; Calivarathan Latchoumycandane, Ph.D., DABT.,; Arthi Kanthasamy; Anumantha G Kanthasamy
Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death.
The Journal of pharmacology and experimental therapeutics 2005;315(1):69-79.
2005: Siddharth Kaul; Vellareddy Anantharam; Anumantha G Kanthasamy; Anumantha G Kanthasamy
Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.
Brain research. Molecular brain research 2005;139(1):137-52.
2005: Siddharth Kaul; Vellareddy Anantharam; Yongjie Yang; Christopher J Choi; Arthi Kanthasamy; Anumantha G Kanthasamy
Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells.
The Journal of biological chemistry 2005;280(31):28721-30.
2005: Anumantha G Kanthasamy; Masashi Kitazawa; Arthi Kanthasamy; Vellareddy Anantharam
Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis.
Neurotoxicology 2005;26(4):701-19.
2005: Calivarathan Latchoumycandane, Ph.D., DABT.,; Vellareddy Anantharam; Masashi Kitazawa; Yongjie Yang; Arthi Kanthasamy; Anumantha G Kanthasamy
Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.
The Journal of pharmacology and experimental therapeutics 2005;313(1):46-55.
2005: Masashi Kitazawa; Vellareddy Anantharam; Yongjie Yang; Yoko Hirata; Anumantha G Kanthasamy; Anumantha G Kanthasamy
Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.
Biochemical pharmacology 2005;69(1):133-46.
2004: Vellareddy Anantharam; Masashi Kitazawa; Calivarathan Latchoumycandane, Ph.D., DABT.,; A Kanthasamy; Anumantha G Kanthasamy
Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death.
Annals of the New York Academy of Sciences 2004;1035():271-89.
2004: Masashi Kitazawa; Vellareddy Anantharam; Arthi Kanthasamy; Anumantha G Kanthasamy
Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2.
Neurotoxicology 2004;25(4):589-98.
2004: Yongjie Yang; Siddharth Kaul; Danhui Zhang; Vellareddy Anantharam; Anumantha G Kanthasamy
Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration.
Molecular and cellular neurosciences 2004;25(3):406-21.
2003: A G Kanthasamy; Masashi Kitazawa; Siddharth Kaul; Yongjie Yang; Debomoy K Lahiri; Vellareddy Anantharam; Anumantha G Kanthasamy
Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease.
Annals of the New York Academy of Sciences 2003;1010():683-6.
2003: Anumantha G Kanthasamy; Masashi Kitazawa; Arthi Kanthasamy; Vellareddy Anantharam
Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis.
Antioxidants & redox signaling 2003;5(5):609-20.
2003: Siddharth Kaul; Anumantha G Kanthasamy; Masashi Kitazawa; Vellareddy Anantharam; Anumantha G Kanthasamy
Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.
The European journal of neuroscience 2003;18(6):1387-401.
2003: Lalitha Madhavan; William J Freed; Vellareddy Anantharam; Anumantha G Kanthasamy
5-hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures.
The Journal of pharmacology and experimental therapeutics 2003;304(3):913-23.
2003: Masashi Kitazawa; Vellareddy Anantharam; Anumantha G Kanthasamy
Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration.
Neuroscience 2003;119(4):945-64.
2002: Masashi Kitazawa; Jarrad R Wagner; Michael L Kirby; Vellareddy Anantharam; Anumantha G Kanthasamy
Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl.
The Journal of pharmacology and experimental therapeutics 2002;302(1):26-35.
2002: Vellareddy Anantharam; Masashi Kitazawa; Jarrad Wagner; Siddharth Kaul; Anumantha G Kanthasamy
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1738-51.
2001: Masashi Kitazawa; Vellareddy Anantharam; Anumantha G Kanthasamy
Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells.
Free radical biology & medicine 2001;31(11):1473-85.