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Daniel Dumont

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Phenomena

Disorders

Neovascularization, Pathologic

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Publications

TOP 3
Qing Cai; Daniel J Dumont; Marie Jeansson; Greg Poffenberger; Susan E Quaggin; Aramandla Radhika; Rachel B Reinert; Alena Shostak; W Gray Jerome; Fong Cheng Pan; Priyanka Brahmachary; Marcela Brissova; Alvin C Powers
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.
Gurpreet K Lakhanpal; Laura M Vecchiarelli-Federico; You-Jun Li; Jiu-Wei Cui; Monica L Bailey; David E Spaner; Daniel J Dumont; Dwayne Barber; Yaacov Ben David
The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.
Celina Sturk; Harold Kim; Nina Jones; Daniel J Dumont
A negative regulatory role for Y1111 on the Tie-2 RTK.

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All Publications

2012: Qing Cai; Daniel J Dumont; Marie Jeansson; Greg Poffenberger; Susan E Quaggin; Aramandla Radhika; Rachel B Reinert; Alena Shostak; W Gray Jerome; Fong Cheng Pan; Priyanka Brahmachary; Marcela Brissova; Alvin C Powers
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.
Developmental biology 2012;367(1):40-54.
2010: Gurpreet K Lakhanpal; Laura M Vecchiarelli-Federico; You-Jun Li; Jiu-Wei Cui; Monica L Bailey; David E Spaner; Daniel J Dumont; Dwayne Barber; Yaacov Ben David
The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis.
Blood 2010;116(3):428-36.
2010: Celina Sturk; Harold Kim; Nina Jones; Daniel J Dumont
A negative regulatory role for Y1111 on the Tie-2 RTK.
Cellular signalling 2010;22(4):676-83.
2010: Adam Tuer; Danielle Tokarz; Nicole Prent; Richard Cisek; Jennifer Alami; Daniel J Dumont; L Bakueva; John Rowlands; Virginijus Barzda
Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections.
Journal of biomedical optics 2010;15(2):026018.
2010: Shahrzad Jalali; Yuexi Huang; Daniel J Dumont; Kullervo Hynynen
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.
BMC neurology 2010;10():114.
2010: Vicky Pkh Nguyen; Stephen H Chen; Katerina Pizzuto; Alyssa Cantarutti; Alyssa Terminesi; Cassandra Mendonca; Daniel J Dumont
25-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner.
Journal of angiogenesis research 2010;2():24.
2010: Celina Sturk; Daniel J Dumont
Tyrosine phosphorylation of Grb14 by Tie2.
Cell communication and signaling : CCS 2010;8():30.
2009: Christina Wehrle; Paul Van Slyke; Daniel J Dumont
Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
The Biochemical journal 2009;423(3):375-80.
2009: Lakshmi Kugathasan; Julie Basu Ray; Yupu Deng; Effat Rezaei; Daniel J Dumont; Duncan J Stewart
The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice.
The Journal of experimental medicine 2009;206(10):2221-34.
2009: Elena Bogdanovic; Neil Coombs; Daniel J Dumont
Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1.
Histochemistry and cell biology 2009;132(2):225-37.
2008: Marja Lohela; Hanna Heloterä; Paula Haiko; Daniel J Dumont; Kari Alitalo
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
The American journal of pathology 2008;173(6):1891-901.
2008: John M L Ebos; Christina Lee; Elena Bogdanovic; Jennifer Alami; Paul Van Slyke; Giulio Francia; Ping Xu; Anthony J Mutsaers; Daniel J Dumont; Robert S Kerbel
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth.
Cancer research 2008;68(2):521-9.
2007: Sarah D McCarter; Shirley H J Mei; Patrick F H Lai; Qiu Wang Zhang; Colleen H Parker; Renée S Suen; Roberta D Hood; Yidan D Zhao; Yupu Deng; Robin N Han; Daniel J Dumont; Duncan J Stewart
Cell-based angiopoietin-1 gene therapy for acute lung injury.
American journal of respiratory and critical care medicine 2007;175(10):1014-26.
2007: Azadeh Jila; Harold Kim; Vicky P K H Nguyen; Daniel J Dumont; John Semple; Dianna Armstrong; Eva Seto; Miles Johnston
Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep.
Microvascular research 2007;73(3):214-23.
2007: Vicky P K H Nguyen; Stephen H Chen; Jason Trinh; Harold Kim; Brenda L Coomber; Daniel J Dumont
Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.
BMC cell biology 2007;8():10.
2006: Betsy N Perry; Baskaran Govindarajan; Sulochana S Bhandarkar; Ulla G Knaus; Monika Valo; Celina Sturk; Carol O Carrillo; Allie Sohn; Francesca Cerimele; Daniel J Dumont; Albert Losken; Joseph Williams; Lawrence F Brown; Xiaolian Tan; Ella Ioffe; George D Yancopoulos; Jack L Arbiser
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
The Journal of investigative dermatology 2006;126(10):2316-22.
2006: Elena Bogdanovic; Vicky P K H Nguyen; Daniel J Dumont
Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization.
Journal of cell science 2006;119(Pt 17):3551-60.
2006: Hanako Kobayashi; Laura M DeBusk; Yael Olya Babichev; Daniel J Dumont; P Charles Lin
Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.
Blood 2006;108(4):1260-6.
2006: W Bureau; Paul Van Slyke; Jamie Jones; Robin N Han; Nicole L Ward; Duncan J Stewart; Daniel J Dumont
Chronic systemic delivery of angiopoietin-2 reveals a possible independent angiogenic effect.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H948-56.
2006: Alexandra L Haninec; Daniel Voskas; Andrew Needles; Allison S Brown; F Stuart Foster; Daniel J Dumont
Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture.
Biochemical and biophysical research communications 2006;345(4):1299-307.
2006: Isao Hamaguchi; Tohru Morisada; Masaki Azuma; Kyoko Murakami; Madoka Kuramitsu; Takuo Mizukami; Kazuyuki Ohbo; Kazunari Yamaguchi; Yuichi Oike; Daniel J Dumont; Toshio Suda
Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.
Blood 2006;107(3):1207-13.
2005: Kelly E Fathers; Courtney M Stone; Kanwal Minhas; Jason J A Marriott; Janice D Greenwood; Daniel J Dumont; Brenda L Coomber
Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy.
The American journal of pathology 2005;167(6):1753-62.
2005: Stephen H Chen; Yael Olya Babichev; Natalie Rodrigues; Daniel Voskas; Ling Ling; Vicky P K H Nguyen; Daniel J Dumont
Gene expression analysis of Tek/Tie2 signaling.
Physiological genomics 2005;22(2):257-67.
2005: Paul Van Slyke; Mariano Loza Coll; Zubin Master; Harold Kim; Jorge Filmus; Daniel J Dumont
Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.
Molecular and cellular biology 2005;25(9):3831-41.
2005: Daniel Voskas; Nina Jones; Paul Van Slyke; Celina Sturk; Wing Chang; Alexandra L Haninec; Yael Olya Babichev; Jennifer Tran; Zubin Master; Stephen Chen; Nicole Ward; Maribelle Cruz; Jamie Jones; Robert S Kerbel; Serge Jothy; Lina Dagnino; Jack Arbiser; Giannoula Klement; Daniel J Dumont
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.
The American journal of pathology 2005;166(3):843-55.
2005: Nicole L Ward; Tracy Putoczki; Karen Mearow; Tammy L Ivanco; Daniel J Dumont
Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes.
The Journal of comparative neurology 2005;482(3):244-56.
2005: Yuval Shaked; Francesco Bertolini; Shan Man; Michael S Rogers; Dave Cervi; Thomas Foutz; Kimberley Rawn; Daniel Voskas; Daniel J Dumont; Yaacov Ben David; Jack Lawler; Jack Henkin; Jim Huber; Daniel J Hicklin; Robert J D'Amato; Robert S Kerbel
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.
Cancer cell 2005;7(1):101-11.
2004: Nicole L Ward; Paul Van Slyke; Daniel J Dumont
Functional inhibition of secreted angiopoietin: a novel role for angiopoietin 1 in coronary vessel patterning.
Biochemical and biophysical research communications 2004;323(3):937-46.
2004: Nicole L Ward; Alexandra L Haninec; Paul Van Slyke; John G Sled; Celina Sturk; R Mark Henkelman; Ian Wanless; Daniel J Dumont
Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.
The American journal of pathology 2004;165(3):889-99.
2004: Qi Niu; Carole Perruzzi; Daniel Voskas; Jack Lawler; Daniel J Dumont; Laura E Benjamin
Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.
Cancer biology & therapy 2004;3(4):402-5.
2004: Nicole L Ward; Paul Van Slyke; Celina Sturk; Maribelle Cruz; Daniel J Dumont
Angiopoietin 1 expression levels in the myocardium direct coronary vessel development.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;229(3):500-9.
2003: Harold Kim; Daniel J Dumont
Molecular mechanisms in lymphangiogenesis: model systems and implications in human disease.
Clinical genetics 2003;64(4):282-92.
2003: Zubin Master; Jennifer Tran; Aseem Bishnoi; Stephen H Chen; John M L Ebos; Paul Van Slyke; Robert S Kerbel; Daniel J Dumont
Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.
The Journal of biological chemistry 2003;278(32):30170-9.
2003: Saeid Babaei; Krystyna Teichert-Kuliszewska; Qiuwang Zhang; Nina Jones; Daniel J Dumont; Duncan J Stewart
Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.
The American journal of pathology 2003;162(6):1927-36.
2003: Nina Jones; Stephen H Chen; Celina Sturk; Zubin Master; Jennifer Tran; Robert S Kerbel; Daniel J Dumont
A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.
Molecular and cellular biology 2003;23(8):2658-68.
2002: John M L Ebos; Jennifer Tran; Zubin Master; Daniel J Dumont; Junia V Melo; Elisabeth Buchdunger; Robert S Kerbel
Imatinib mesylate (STI-571) reduces Bcr-Abl-mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia.
Molecular cancer research : MCR 2002;1(2):89-95.
2002: Jennifer Tran; Zubin Master; Joanne L Yu; Janusz Rak; Daniel J Dumont; Robert S Kerbel
A role for survivin in chemoresistance of endothelial cells mediated by VEGF.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4349-54.
2002: Nicole L Ward; Daniel J Dumont
The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.
Seminars in cell & developmental biology 2002;13(1):19-27.
2001: Zubin Master; Nina Jones; Jennifer Tran; Jamie Jones; Robert S Kerbel; Daniel J Dumont
Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.
The EMBO journal 2001;20(21):5919-28.
2001: Nina Jones; Daniel Voskas; Zubin Master; Renu Sarao; Jamie Jones; Daniel J Dumont
Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function.
EMBO reports 2001;2(5):438-45.
2001: Nina Jones; K Iljin; Daniel J Dumont; Kari Alitalo
Tie receptors: new modulators of angiogenic and lymphangiogenic responses.
Nature reviews. Molecular cell biology 2001;2(4):257-67.
2001: Krystyna Teichert-Kuliszewska; P C Maisonpierre; Nina Jones; Andrew I M Campbell; Zubin Master; Michelle P Bendeck; Kari Alitalo; Daniel J Dumont; G D Yancopoulos; Duncan J Stewart
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.
Cardiovascular research 2001;49(3):659-70.
2000: Koichi Hamada; Yuichi Oike; Nobuyuki Takakura; Yasuhiro Ito; Lotta Jussila; Daniel J Dumont; Kari Alitalo; Toshio Suda
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.
Blood 2000;96(12):3793-800.
2000: B Zochodne; Amandine H L Truong; K Stetler; RR Higgins; J Howard; Daniel J Dumont; Stuart A Berger; Yaacov Ben David
Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia.
Oncogene 2000;19(19):2296-304.
2000: Jacqueline M Mason; Bryan K Beattie; Q Liu; Daniel J Dumont; Dwayne Barber
The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.
The Journal of biological chemistry 2000;275(6):4398-406.
2000: Nina Jones; Daniel J Dumont
Tek/Tie2 signaling: new and old partners.
Cancer metastasis reviews 2000;19(1-2):13-7.
1999: Nina Jones; Zubin Master; Jamie Jones; Denis Bouchard; Y Gunji; H Sasaki; R Daly; Kari Alitalo; Daniel J Dumont
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Journal of biological chemistry 1999;274(43):30896-905.
1999: Nina Jones; Daniel J Dumont
Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation.
Current biology : CB 1999;9(18):1057-60.
1999: Q Liu; T Sasaki; Ivona Kozieradzki; Andrew Wakeham; Annick Itie; Daniel J Dumont; Josef M Penninger
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.
Genes & development 1999;13(7):786-91.
1998: Renu Sarao; Daniel J Dumont
Conditional transgene expression in endothelial cells.
Transgenic research 1998;7(6):421-7.
1998: Nobuyuki Takakura; XL Huang; T Naruse; Isao Hamaguchi; Daniel J Dumont; G D Yancopoulos; Toshio Suda
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis.
Immunity 1998;9(5):677-86.
1998: Daniel J Dumont; Lotta Jussila; Jussi Taipale; A Lymboussaki; T Mustonen; Katri Pajusola; M Breitman; Kari Alitalo
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.
Science (New York, N.Y.) 1998;282(5390):946-9.
1998: Q Liu; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; J Jones; Renu Sarao; Ivona Kozieradzki; Pamela S Ohashi; Josef M Penninger; Daniel J Dumont
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
The Journal of experimental medicine 1998;188(7):1333-42.
1998: Nina Jones; Daniel J Dumont
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.
Oncogene 1998;17(9):1097-108.
1998: Q Liu; F Shalaby; J Jones; Denis Bouchard; Daniel J Dumont
The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis.
Blood 1998;91(8):2753-9.
1995: J Korhonen; I Lahtinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; Daniel J Dumont; Kari Alitalo
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1995: A Kaipainen; J Korhonen; Tuija Mustonen; V W van Hinsbergh; G H Fang; Daniel J Dumont; M Breitman; Kari Alitalo
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3566-70.