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Francis Dumont

Research Profile

Anatomy

Chemicals & Drugs

Living Beings

Physiology

Lymphocyte Activation

Disorders

Lymphoma, T-Cell

Co-author Network

Publications

TOP 3
Sam L Koprak; Stephen Matheravidathu; Martin Springer; Sandra Gould; Francis J Dumont
Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin.
Francis J Dumont
FK506, an immunosuppressant targeting calcineurin function.
Gloria C Koo; JT Blake; Kashmira Shah; Mary Jo Staruch; Francis J Dumont; Denise Wunderler; Manuel Sanchez; Owen B McManus; A Sirotina-Meisher; P Fischer; R C Boltz; Michael A Goetz; R Baker; Jianming Bao; Frank Kayser; Kathleen M Rupprecht; William H Parsons; X C Tong; I E Ita; James V Pivnichny; S Vincent; P Cunningham; Donald F Hora; William P Feeney; Gregory J Kaczorowski
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels.

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All Publications

2003: Sam L Koprak; Stephen Matheravidathu; Martin Springer; Sandra Gould; Francis J Dumont
Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin.
Cellular immunology 2003;223(1):1-12.
2000: Francis J Dumont
FK506, an immunosuppressant targeting calcineurin function.
Current medicinal chemistry 2000;7(7):731-48.
1999: Gloria C Koo; JT Blake; Kashmira Shah; Mary Jo Staruch; Francis J Dumont; Denise Wunderler; Manuel Sanchez; Owen B McManus; A Sirotina-Meisher; P Fischer; R C Boltz; Michael A Goetz; R Baker; Jianming Bao; Frank Kayser; Kathleen M Rupprecht; William H Parsons; X C Tong; I E Ita; James V Pivnichny; S Vincent; P Cunningham; Donald F Hora; William P Feeney; Gregory J Kaczorowski
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels.
Cellular immunology 1999;197(2):99-107.
1999: H M Armstrong; Frederick Wong; M A Holmes; Peter J Sinclair; Mark T Goulet; Francis J Dumont; Mary Jo Staruch; Sam L Koprak; Laurence B Peterson; R Rosa; MB Wilusz; GJ Wiederrecht; JG Cryan; Matthew J Wyvratt; William H Parsons
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Bioorganic & medicinal chemistry letters 1999;9(14):2089-94.
1999: Mark T Goulet; Peter J Sinclair; Frederick Wong; Mary Jo Staruch; Francis J Dumont; JG Cryan; GJ Wiederrecht; Matthew J Wyvratt; William H Parsons
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Bioorganic & medicinal chemistry letters 1999;9(14):2085-8.
1999: Sam L Koprak; Mary Jo Staruch; Francis J Dumont
A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production.
Cellular immunology 1999;192(2):87-95.
1998: Mary Jo Staruch; R Camacho; Francis J Dumont
Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cells.
Cellular immunology 1998;190(2):121-31.
1998: Mark T Goulet; S R McAlpine; Mary Jo Staruch; Sam L Koprak; Francis J Dumont; JG Cryan; GJ Wiederrecht; R Rosa; MB Wilusz; Laurence B Peterson; Matthew J Wyvratt; William H Parsons
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.
Bioorganic & medicinal chemistry letters 1998;8(16):2253-8.
1998: Francis J Dumont; Mary Jo Staruch; P Fischer; C DaSilva; R Camacho
Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2579-89.
1996: Q Su; Hans-Pietro Eugster; B Ryffel; Francis J Dumont
Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma.
Biochemical and biophysical research communications 1996;229(1):249-56.
1996: Sam L Koprak; A Sirotina; H Ok; Francis J Dumont
Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities.
Transplantation 1996;61(6):926-32.
1996: Francis J Dumont; H Ok; S Lin; C A Kastner; JG Cryan; M M Martin; GJ Wiederrecht; Mary Jo Staruch
Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1078-88.
1996: Francis J Dumont; Q Su
Mechanism of action of the immunosuppressant rapamycin.
Life sciences 1996;58(5):373-95.
1995: Francis J Dumont; P Fischer; A Sirotina
Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by rapamycin in a T cell lymphoma.
Experimental cell research 1995;219(1):146-58.
1995: Francis J Dumont; Mary Jo Staruch; T Grammer; John Blenis; C A Kastner; Kathleen M Rupprecht
Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma.
Cellular immunology 1995;163(1):70-9.
1995: C J Sabers; M M Martin; GJ Brunn; J M Williams; Francis J Dumont; GJ Wiederrecht; Robert T Abraham
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
The Journal of biological chemistry 1995;270(2):815-22.
1995: GJ Wiederrecht; C J Sabers; GJ Brunn; M M Martin; Francis J Dumont; Robert T Abraham
Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells.
Progress in cell cycle research 1995;1():53-71.
1994: Francis J Dumont; C A Kastner
Transforming growth factor beta 1 inhibits interleukin-1-induced but enhances ionomycin-induced interferon-gamma production in a T cell lymphoma: comparison with the effects of rapamycin.
Journal of cellular physiology 1994;160(1):141-53.
1994: Francis J Dumont; A Altmeyer; C Kastner; P A Fischer; K P Lemon; J Chung; John Blenis; Mary Jo Staruch
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):992-1003.
1994: Francis J Dumont; C Kastner; F Iacovone; P A Fischer
Quantitative and temporal analysis of the cellular interaction of FK-506 and rapamycin in T-lymphocytes.
The Journal of pharmacology and experimental therapeutics 1994;268(1):32-41.
1993: A Altmeyer; Francis J Dumont
Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma.
Cytokine 1993;5(2):133-43.
1992: Francis J Dumont; Mary Jo Staruch; Sam L Koprak; John Siekierka; C S Lin; R Harrison; T Sewell; V M Kindt; T R Beattie; Matthew J Wyvratt
The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
The Journal of experimental medicine 1992;176(3):751-60.
1992: Nolan Sigal; Francis J Dumont
Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction.
Annual review of immunology 1992;10():519-60.
1991: Francis J Dumont; Mary Jo Staruch; A Flattery; A Altmeyer; Nolan Sigal
Up-regulation of gene expression by FK 506.
Transplantation proceedings 1991;23(6):2870-2.
1991: Nolan Sigal; Francis J Dumont; John Siekierka; GJ Wiederrecht; S A Parent; leonardo brizuela
Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?
Transplantation proceedings 1991;23(6):2846-9.
1991: A Altmeyer; Mary Jo Staruch; F Cofano; S Landolfo; Francis J Dumont
Multiple cytokine interactions regulate Ly-6E antigen expression: cooperative Ly-6E induction by IFNs, TNF, and IL-1 in a T cell lymphoma and in its induction-deficient variants.
Cellular immunology 1991;138(1):94-107.
1991: Francis J Dumont; A Altmeyer
Modulation of IFN-mediated Ly-6E antigen induction by cAMP in a T cell lymphoma: opposite effects on the responses to IFN-gamma and IFN-alpha/beta.
Cellular immunology 1991;132(2):466-80.
1991: A Altmeyer; Mary Jo Staruch; P A Fischer; P L Durette; M J Tocci; Nolan Sigal; Francis J Dumont
Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: both immunosuppressants augment Ly-6E antigen induction by interferon-gamma in the presence of ionomycin.
International journal of immunopharmacology 1991;13(8):1187-99.
1991: Mary Jo Staruch; Nolan Sigal; Francis J Dumont
Differential effects of the immunosuppressive macrolides FK-506 and rapamycin on activation-induced T-cell apoptosis.
International journal of immunopharmacology 1991;13(6):677-85.
1990: Nolan Sigal; John Siekierka; Francis J Dumont
Observations on the mechanism of action of FK-506. A pharmacologic probe of lymphocyte signal transduction.
Biochemical pharmacology 1990;40(10):2201-8.
1990: Francis J Dumont; A Altmeyer; Mary Jo Staruch; R Dijkmans; R G Palfree; P A Fischer
Role of protein kinase C in IFN-mediated Ly-6E antigen induction.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3795-803.
1990: Francis J Dumont; M R Melino; Mary Jo Staruch; Sam L Koprak; P A Fischer; Nolan Sigal
The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1418-24.
1990: Francis J Dumont; Mary Jo Staruch; Sam L Koprak; M R Melino; Nolan Sigal
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(1):251-8.
1989: K P LeClair; M M Bridgett; Francis J Dumont; R G Palfree; U Hämmerling; Alfred L M Bothwell
Kinetic analysis of Ly-6 gene induction in a T lymphoma by interferons and interleukin 1, and demonstration of Ly-6 inducibility in diverse cell types.
European journal of immunology 1989;19(7):1233-9.
1988: Francis J Dumont
Recombinant human interferon-alpha A/D enhances the expression of Ly-6A/E, Ly-6C, and TAP antigens on murine T lymphocytes.
Journal of interferon research 1988;8(3):347-56.
1988: Francis J Dumont; R G Palfree; P A Fisher
The T-cell activating protein (TAP) is up-regulated by endogenous IFN-gamma in activated T cells.
Immunology 1988;64(2):267-71.
1988: M Toulon; R G Palfree; S Palfree; Francis J Dumont; U Hämmerling
Ly-6 A/E antigen of murine T cells is associated with a distinct pathway of activation. Requirements for interferon and exogenous interleukin 2.
European journal of immunology 1988;18(6):937-42.
1988: R G Palfree; S Sirlin; Francis J Dumont; U Hämmerling
N-terminal and cDNA characterization of murine lymphocyte antigen Ly-6C.2.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(1):305-10.
1987: Francis J Dumont; R C Boltz
The augmentation of surface Ly-6A/E molecules in activated T cells is mediated by endogenous interferon-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(12):4088-95.
1987: Francis J Dumont; R Dijkmans; R G Palfree; R D Boltz; L Coker
Selective up-regulation by interferon-gamma of surface molecules of the Ly-6 complex in resting T cells: the Ly-6A/E and TAP antigens are preferentially enhanced.
European journal of immunology 1987;17(8):1183-91.
1986: Francis J Dumont; R C Habbersett
Alterations of the T-cell population in BXSB mice: early imbalance of 9F3-defined Lyt-2+ subsets occurs in the males with rapid onset lupic syndrome.
Cellular immunology 1986;101(1):39-50.
1986: Francis J Dumont; L Z Coker
Interferon-alpha/beta enhances the expression of Ly-6 antigens on T cells in vivo and in vitro.
European journal of immunology 1986;16(7):735-40.
1986: Francis J Dumont; R G Palfree; L Z Coker
Phenotypic changes induced by interferon in resting T cells: major enhancement of Ly-6 antigen expression.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):201-10.
1986: R G Palfree; Francis J Dumont; Ulrich Hammerling
Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1.
Immunogenetics 1986;23(3):197-207.
1985: Francis J Dumont; R C Habbersett; L Z Coker; E A Nichols; J A Treffinger
High level expression of the plasma cell antigen PC.1 on the T-cell subset expanding in MRL/MpJ-lpr/lpr mice: detection with a xenogeneic monoclonal antibody and alloantisera.
Cellular immunology 1985;96(2):327-37.
1985: Francis J Dumont; L Z Coker; R C Habbersett; J A Treffinger
Xenogeneic monoclonal antibody to an Ly-6-linked murine cell surface antigen: differential reactivity with T cell subpopulations and bone marrow cells.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(4):2357-65.
1985: Francis J Dumont; R C Habbersett; L Z Coker
Subsets of Lyt-2+ cells defined by differential expression of the 9F3 antigen: alterations in mice of the lpr/lpr genotype.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(1):196-203.
1984: Francis J Dumont; R C Habbersett; E A Nichols
A new lymphocyte surface antigen defined by a monoclonal antibody (9F3) to the T cell population expanding in MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(2):809-15.
1983: Francis J Dumont; R C Habbersett; E A Nichols; J A Treffinger; A S Tung
A monoclonal antibody (100C5) to the Lyt-2-T cell population expanding in MRL/Mp-lpr/lpr mice detects a surface antigen normally expressed on Lyt-2+ cells and B cells.
European journal of immunology 1983;13(6):455-9.
1983: M R Melino; Francis J Dumont; R C Habbersett; T H Hansen
Expression of a bone marrow-associated Ly-6 determinant on the T cell population expanding in the lymph nodes of the autoimmune mouse strain MRL/Mp-lpr/lpr.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(4):1843-7.