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Debra Dunaway-Mariano

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Chun Wu; Debra Dunaway-Mariano; Patrick S Mariano
Design, synthesis, and evaluation of inhibitors of pyruvate phosphate dikinase.
Danqi Chen; Jeremiah Farelli; John Latham; Hong Zhao; Marco Bisoffi; Debra Dunaway-Mariano
Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.
Feng Song; James B Thoden; Michael Trujillo; Zhihao Zhuang; Hazel M Holden; John Latham; Debra Dunaway-Mariano
The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.

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All Publications

2013: Chun Wu; Debra Dunaway-Mariano; Patrick S Mariano
Design, synthesis, and evaluation of inhibitors of pyruvate phosphate dikinase.
The Journal of organic chemistry 2013;78(5):1910-22.
2012: Danqi Chen; Jeremiah Farelli; John Latham; Hong Zhao; Marco Bisoffi; Debra Dunaway-Mariano
Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.
Biochemistry 2012;51(35):6990-9.
2012: Feng Song; James B Thoden; Michael Trujillo; Zhihao Zhuang; Hazel M Holden; John Latham; Debra Dunaway-Mariano
The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.
Biochemistry 2012;51(35):7000-16.
2012: Hong Zhao; Anthony Choudry; Dennis Dominguez; Osnat Herzberg; John A Latham; Kap Lim; Lusong Luo; Manish C Pathak; Debra Dunaway-Mariano
Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Biochemistry 2012;51(33):6490-2.
2012: Zhihao Zhuang; John Latham; Feng Song; Michael Trujillo; Wenhai Zhang; Debra Dunaway-Mariano
Investigation of the catalytic mechanism of the hotdog-fold enzyme superfamily Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase.
Biochemistry 2012;51(3):786-94.
2011: John Alan Gerlt; Heidi J Imker; Matthew P Jacobson; Wladek Minor; C Dale Poulter; Frank M Raushel; Andrej Sali; Brian K Shoichet; Karen N Allen; Steven C Almo; Richard N Armstrong; Patricia C Babbitt; John E Cronan; Debra Dunaway-Mariano; Jonathan V Sweedler
The Enzyme Function Initiative.
Biochemistry 2011;50(46):9950-62.
2011: Zhibing Lu; Debra Dunaway-Mariano; Karen N Allen
The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: comparison of paralogous functions in B. thetaiotaomicron.
Proteins 2011;79(11):3099-107.
2011: Hua Huang; Chetanya Pandya; Yury Patskovsky; Rafael Toro; Karen N Allen; Steven C Almo; Jeremiah D Farelli; Debra Dunaway-Mariano
Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.
Biochemistry 2011;50(41):8937-49.
2011: Alexander Kim; Matthew M Benning; Sang OkLee; John Quinn; Brian M Martin; Hazel M Holden; Debra Dunaway-Mariano
Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.
Biochemistry 2011;50(17):3481-94.
2011: Rui Wu; Megan Garland; Debra Dunaway-Mariano; Karen N Allen
Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.
Biochemistry 2011;50(15):3045-7.
2011: Dae Won Cho; John A Latham; Hea Jung Park; Ung Chan Yoon; Paul Langan; Debra Dunaway-Mariano; Patrick S Mariano
Regioselectivity of enzymatic and photochemical single electron transfer promoted carbon-carbon bond fragmentation reactions of tetrameric lignin model compounds.
The Journal of organic chemistry 2011;76(8):2840-52.
2011: Zhimin Li; Zhengang Liu; Dae Won Cho; Jiwen Zou; Maozhen Gong; Robert M Breece; Andrey Galkin; Ling Li; Hong Zhao; Gabriel D Maestas; David L Tierney; Osnat Herzberg; Debra Dunaway-Mariano; Patrick S Mariano
Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.
Journal of inorganic biochemistry 2011;105(4):509-17.
2010: Dae Won Cho; Ramakrishnan Parthasarathi; Adam S Pimentel; Gabriel D Maestas; Hea Jung Park; Ung Chan Yoon; Debra Dunaway-Mariano; S Gnanakaran; Paul Langan; Patrick S Mariano
Nature and kinetic analysis of carbon-carbon bond fragmentation reactions of cation radicals derived from SET-oxidation of lignin model compounds.
The Journal of organic chemistry 2010;75(19):6549-62.
2010: Andrey Galkin; Liudmila Kulakova; Rui Wu; Theodore E Nash; Debra Dunaway-Mariano; Osnat Herzberg
X-ray structure and characterization of carbamate kinase from the human parasite Giardia lamblia.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 4):386-90.
2010: Liangbing Wang; Hua Huang; Henry Nguyen; Karen N Allen; Patrick S Mariano; Debra Dunaway-Mariano
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
Biochemistry 2010;49(6):1072-81.
2010: Henry Nguyen; Liangbing Wang; Hua Huang; Ezra Peisach; Debra Dunaway-Mariano; Karen N Allen
Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) .
Biochemistry 2010;49(6):1082-92.
2009: Karen N Allen; Debra Dunaway-Mariano
Markers of fitness in a successful enzyme superfamily.
Current opinion in structural biology 2009;19(6):658-65.
2009: Zhili Li; Feng Song; Zhihao Zhuang; Debra Dunaway-Mariano; Karen S Anderson
Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry.
Analytical biochemistry 2009;394(2):209-16.
2009: Zhimin Li; Liudmila Kulakova; Ling Li; Andrey Galkin; Zhiming Zhao; Theodore E Nash; Patrick S Mariano; Osnat Herzberg; Debra Dunaway-Mariano
Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia.
Bioorganic chemistry 2009;37(5):149-61.
2009: Andrey Galkin; Liudmila Kulakova; Rui Wu; Maozhen Gong; Debra Dunaway-Mariano; Osnat Herzberg
X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia.
Proteins 2009;76(4):1049-53.
2009: Hong Zhao; Brian M Martin; Marco Bisoffi; Debra Dunaway-Mariano
The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.
Biochemistry 2009;48(24):5507-9.
2009: Rui Wu; Albert S Reger; Xuefeng Lu; Andrew Gulick; Debra Dunaway-Mariano
The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase.
Biochemistry 2009;48(19):4115-25.
2009: Andrey Galkin; Zhimin Li; Ling Li; Liudmila Kulakova; Lipika R Pal; Debra Dunaway-Mariano; Osnat Herzberg
Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.
Biochemistry 2009;48(14):3186-96.
2009: Jianying Dai; Lorenzo Finci; Chunchun Zhang; Sushmita Lahiri; Guofeng Zhang; Ezra Peisach; Karen N Allen; Debra Dunaway-Mariano
Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.
Biochemistry 2009;48(9):1984-95.
2009: Buvaneswari Narayanan; Weiling Niu; Henk-Jan Joosten; Zhimin Li; Remko K P Kuipers; Peter J Schaap; Debra Dunaway-Mariano; Osnat Herzberg
Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member.
Journal of molecular biology 2009;386(2):486-503.
2009: Jian Cao; Hang Xu; Hong Zhao; Weimin Gong; Debra Dunaway-Mariano
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis.
Biochemistry 2009;48(6):1293-304.
2009: Danqi Chen; Rui Wu; Tyrel L Bryan; Debra Dunaway-Mariano
In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH.
Biochemistry 2009;48(3):511-3.
2009: Zhibing Lu; Liangbing Wang; Debra Dunaway-Mariano; Karen N Allen
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.
The Journal of biological chemistry 2009;284(2):1224-33.
2008: Debra Dunaway-Mariano
Enzyme function discovery.
Structure (London, England : 1993) 2008;16(11):1599-600.
2008: Liangbing Wang; Zhibing Lu; Karen N Allen; Patrick S Mariano; Debra Dunaway-Mariano
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
Chemistry & biology 2008;15(9):893-7.
2008: Rui Wu; Jian Cao; Xuefeng Lu; Albert S Reger; Andrew Gulick; Debra Dunaway-Mariano
Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis.
Biochemistry 2008;47(31):8026-39.
2008: Albert S Reger; Rui Wu; Debra Dunaway-Mariano; Andrew Gulick
Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase.
Biochemistry 2008;47(31):8016-25.
2008: Ling Li; Zhimin Li; Canhui Wang; Dingguo Xu; Patrick S Mariano; Hua Guo; Debra Dunaway-Mariano
The electrostatic driving force for nucleophilic catalysis in L-arginine deiminase: a combined experimental and theoretical study.
Biochemistry 2008;47(16):4721-32.
2008: Zhibing Lu; Debra Dunaway-Mariano; Karen N Allen
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5687-92.
2008: Mark A Willis; Zhihao Zhuang; Feng Song; Andrew Howard; Debra Dunaway-Mariano; Osnat Herzberg
Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase.
Biochemistry 2008;47(9):2797-805.
2008: Zhihao Zhuang; Feng Song; Hong Zhao; Ling Li; Jian Cao; Edward Eisenstein; Osnat Herzberg; Debra Dunaway-Mariano
Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA.
Biochemistry 2008;47(9):2789-96.
2008: Ling Li; Zhimin Li; Danqi Chen; Xuefeng Lu; Xiaohua Feng; Elizabeth C Wright; Nathan O Solberg; Debra Dunaway-Mariano; Patrick S Mariano; Andrey Galkin; Liudmila Kulakova; Osnat Herzberg; Kari B Green-Church; Liwen Zhang
Inactivation of microbial arginine deiminases by L-canavanine.
Journal of the American Chemical Society 2008;130(6):1918-31.
2008: Buvaneswari C Narayanan; Weiling Niu; Ying Han; Jiwen Zou; Patrick S Mariano; Debra Dunaway-Mariano; Osnat Herzberg
Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
Biochemistry 2008;47(1):167-82.
2008: Henk-Jan Joosten; Ying Han; Weiling Niu; Jacques Vervoort; Debra Dunaway-Mariano; Peter J Schaap
Identification of fungal oxaloacetate hydrolyase within the isocitrate lyase/PEP mutase enzyme superfamily using a sequence marker-based method.
Proteins 2008;70(1):157-66.
2008: Ezra Peisach; Liangbing Wang; A Maxwell Burroughs; L Aravind; Debra Dunaway-Mariano; Karen N Allen
The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function.
Proteins 2008;70(1):197-207.
2007: Kap Lim; Randy J Read; Celia C H Chen; Aleksandra Tempczyk; Min Wei; Dongmei Ye; Chun Wu; Debra Dunaway-Mariano; Osnat Herzberg
Swiveling domain mechanism in pyruvate phosphate dikinase.
Biochemistry 2007;46(51):14845-53.
2007: Rui Wu; Albert S Reger; Jian Cao; Andrew Gulick; Debra Dunaway-Mariano
Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range.
Biochemistry 2007;46(50):14487-99.
2007: Ying Han; Henk-Jan Joosten; Weiling Niu; Zhiming Zhao; Patrick S Mariano; Melisa McCalman; Jan van Kan; Peter J Schaap; Debra Dunaway-Mariano
Oxaloacetate hydrolase, the C-C bond lyase of oxalate secreting fungi.
The Journal of biological chemistry 2007;282(13):9581-90.
2007: Andrey Galkin; Liudmila Kulakova; Eugene Melamud; Ling Li; Chun Wu; Patrick S Mariano; Debra Dunaway-Mariano; Theodore E Nash; Osnat Herzberg
Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia.
The Journal of biological chemistry 2007;282(7):4859-67.
2007: Feng Song; Zhihao Zhuang; Debra Dunaway-Mariano
Structure-activity analysis of base and enzyme-catalyzed 4-hydroxybenzoyl coenzyme A hydrolysis.
Bioorganic chemistry 2007;35(1):1-10.
2006: Sushmita D Lahiri; Guofeng Zhang; Debra Dunaway-Mariano; Karen N Allen
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.
Bioorganic chemistry 2006;34(6):394-409.
2006: Zhongjun Cheng; Feng Song; Xiaoyue Shan; Zhiyi Wei; Yanli Wang; Debra Dunaway-Mariano; Weimin Gong
Crystal structure of human thioesterase superfamily member 2.
Biochemical and biophysical research communications 2006;349(1):172-7.
2006: Celia C H Chen; Ying Han; Weiling Niu; Anna N Kulakova; Andrew Howard; John P Quinn; Debra Dunaway-Mariano; Osnat Herzberg
Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily.
Biochemistry 2006;45(38):11491-504.
2006: A Maxwell Burroughs; Karen N Allen; Debra Dunaway-Mariano; L Aravind
Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes.
Journal of molecular biology 2006;361(5):1003-34.
2006: Jianying Dai; Liangbing Wang; Karen N Allen; Peter Radstrom; Debra Dunaway-Mariano
Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.
Biochemistry 2006;45(25):7818-24.
2006: Nicholas R Silvaggi; Chunchun Zhang; Zhibing Lu; Jianying Dai; Debra Dunaway-Mariano; Karen N Allen
The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a.
The Journal of biological chemistry 2006;281(21):14918-26.
2006: Feng Song; Zhihao Zhuang; Lorenzo Finci; Debra Dunaway-Mariano; Ryan Kniewel; John A Buglino; Veronica Solorzano; Jin Wu; Christopher D Lima
Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI.
The Journal of biological chemistry 2006;281(16):11028-38.
2006: Ying Lin; Jacqueline D Lusin; Dongmei Ye; Debra Dunaway-Mariano; James B Ames
Examination of the structure, stability, and catalytic potential in the engineered phosphoryl carrier domain of pyruvate phosphate dikinase.
Biochemistry 2006;45(6):1702-11.
2006: Lee W Tremblay; Debra Dunaway-Mariano; Karen N Allen
Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily.
Biochemistry 2006;45(4):1183-93.
2006: Xuefeng Lu; Ling Li; Rui Wu; Xiaohua Feng; Zhimin Li; Heyi Yang; Canhui Wang; Hua Guo; Andrey Galkin; Osnat Herzberg; Patrick S Mariano; Brian M Martin; Debra Dunaway-Mariano
Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function.
Biochemistry 2006;45(4):1162-72.
2006: Jingbo Wu; Dingguo Xu; Xuefeng Lu; Canhui Wang; Hua Guo; Debra Dunaway-Mariano
Contributions of long-range electrostatic interactions to 4-chlorobenzoyl-CoA dehalogenase catalysis: a combined theoretical and experimental study.
Biochemistry 2006;45(1):102-12.
2005: Alexey Teplyakov; Sijiu Liu; Zhibing Lu; Andrew Howard; Debra Dunaway-Mariano; Osnat Herzberg
Crystal structure of the petal death protein from carnation flower.
Biochemistry 2005;44(50):16377-84.
2005: Zhibing Lu; Xiaohua Feng; Ling Song; Ying Han; Alexander Kim; Osnat Herzberg; William R Woodson; Brian M Martin; Patrick S Mariano; Debra Dunaway-Mariano
Diversity of function in the isocitrate lyase enzyme superfamily: the Dianthus caryophyllus petal death protein cleaves alpha-keto and alpha-hydroxycarboxylic acids.
Biochemistry 2005;44(50):16365-76.
2005: Xuefeng Lu; Ling Li; Xiaohua Feng; Yan Wu; Debra Dunaway-Mariano; John R Engen; Patrick S Mariano
L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase.
Journal of the American Chemical Society 2005;127(47):16412-3.
2005: Andrey Galkin; Xuefeng Lu; Debra Dunaway-Mariano; Osnat Herzberg
Crystal structures representing the Michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase.
The Journal of biological chemistry 2005;280(40):34080-7.
2005: Guofeng Zhang; Jianying Dai; Liangbing Wang; Debra Dunaway-Mariano; Lee W Tremblay; Karen N Allen
Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis.
Biochemistry 2005;44(27):9404-16.
2005: Zhibing Lu; Debra Dunaway-Mariano; Karen N Allen
HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.
Biochemistry 2005;44(24):8684-96.
2005: Mark A Willis; Feng Song; Zhihao Zhuang; Wojciech Krajewski; Vani Rao Chalamasetty; Prasad Reddy; Andrew Howard; Debra Dunaway-Mariano; Osnat Herzberg
Structure of YciI from Haemophilus influenzae (HI0828) reveals a ferredoxin-like alpha/beta-fold with a histidine/aspartate centered catalytic site.
Proteins 2005;59(3):648-52.
2005: Lee W Tremblay; Guofeng Zhang; Jianying Dai; Debra Dunaway-Mariano; Karen N Allen
Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase.
Journal of the American Chemical Society 2005;127(15):5298-9.
2005: Sijiu Liu; Zhibing Lu; Yin Han; Eugene Melamud; Debra Dunaway-Mariano; Osnat Herzberg
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution.
Biochemistry 2005;44(8):2949-62.
2004: Dingguo Xu; Yanseng Wei; Jingbo Wu; Debra Dunaway-Mariano; Hua Guo; Qiang Cui; Jiali Gao
QM/MM studies of the enzyme-catalyzed dechlorination of 4-chlorobenzoyl-CoA provide insight into reaction energetics.
Journal of the American Chemical Society 2004;126(42):13649-58.
2004: Ezra Peisach; Jeremy D Selengut; Debra Dunaway-Mariano; Karen N Allen
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.
Biochemistry 2004;43(40):12770-9.
2004: Karen N Allen; Debra Dunaway-Mariano
Phosphoryl group transfer: evolution of a catalytic scaffold.
Trends in biochemical sciences 2004;29(9):495-503.
2004: Andrew Gulick; Xuefeng Lu; Debra Dunaway-Mariano
Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states.
Biochemistry 2004;43(27):8670-9.
2004: Xuefeng Lu; Andrey Galkin; Osnat Herzberg; Debra Dunaway-Mariano
Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis.
Journal of the American Chemical Society 2004;126(17):5374-5.
2004: Guofeng Zhang; Marc C Morais; Jianying Dai; Wenhai Zhang; Debra Dunaway-Mariano; Karen N Allen
Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily.
Biochemistry 2004;43(17):4990-7.
2004: Sijiu Liu; Zhibing Lu; Ying Han; Yong Jia; Andrew Howard; Debra Dunaway-Mariano; Osnat Herzberg
Conformational flexibility of PEP mutase.
Biochemistry 2004;43(15):4447-53.
2004: Sushmita D Lahiri; Guofeng Zhang; Jianying Dai; Debra Dunaway-Mariano; Karen N Allen
Analysis of the substrate specificity loop of the HAD superfamily cap domain.
Biochemistry 2004;43(10):2812-20.
2004: Marc C Morais; Guofeng Zhang; Wenhai Zhang; David B Olsen; Debra Dunaway-Mariano; Karen N Allen
X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis.
The Journal of biological chemistry 2004;279(10):9353-61.
2004: Zhihao Zhuang; Feng Song; Hideto Takami; Debra Dunaway-Mariano
The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase.
Journal of bacteriology 2004;186(2):393-9.
2003: Guofeng Zhang; Karen N Allen; Debra Dunaway-Mariano
Enzymatic synthesis of radiolabeled phosphonoacetaldehyde.
Analytical biochemistry 2003;322(2):233-7.
2003: James B Thoden; Zhihao Zhuang; Debra Dunaway-Mariano; Hazel M Holden
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU.
The Journal of biological chemistry 2003;278(44):43709-16.
2003: Guofeng Zhang; Jiaying Dai; Zhibing Lu; Debra Dunaway-Mariano
The phosphonopyruvate decarboxylase from Bacteroides fragilis.
The Journal of biological chemistry 2003;278(42):41302-8.
2003: Jian Dong; Xuefeng Lu; Yansheng Wei; Lusong Luo; Debra Dunaway-Mariano; Paul R Carey
The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation.
Biochemistry 2003;42(31):9482-90.
2003: Zhihao Zhuang; Karl-Heinz Gartemann; Rudolf Eichenlaub; Debra Dunaway-Mariano
Characterization of the 4-hydroxybenzoyl-coenzyme A thioesterase from Arthrobacter sp. strain SU.
Applied and environmental microbiology 2003;69(5):2707-11.
2003: Sushmita D Lahiri; Guofeng Zhang; Debra Dunaway-Mariano; Karen N Allen
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction.
Science (New York, N.Y.) 2003;299(5615):2067-71.
2002: Guofeng Zhang; Andrew Mazurkie; Debra Dunaway-Mariano; Karen N Allen
Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis.
Biochemistry 2002;41(45):13370-7.
2002: Zhihao Zhuang; Feng Song; Wenhai Zhang; Kimberly Taylor; Angela Archambault; Debra Dunaway-Mariano; Jian Dong; Paul R Carey
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site.
Biochemistry 2002;41(37):11152-60.
2002: Sijiu Liu; Zhibing Lu; Yong Jia; Debra Dunaway-Mariano; Osnat Herzberg
Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants.
Biochemistry 2002;41(32):10270-6.
2002: Alexander D Kim; Angela S Baker; Debra Dunaway-Mariano; W W Metcalf; B L Wanner; Brian M Martin
The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway.
Journal of bacteriology 2002;184(15):4134-40.
2002: James B Thoden; Hazel M Holden; Zhihao Zhuang; Debra Dunaway-Mariano
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.
The Journal of biological chemistry 2002;277(30):27468-76.
2002: Sushmita D Lahiri; Guofeng Zhang; Debra Dunaway-Mariano; Karen N Allen
Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis.
Biochemistry 2002;41(26):8351-9.
2002: Jian Dong; Paul R Carey; Yansheng Wei; Lusong Luo; Xuefeng Lu; Rui-Qin Liu; Debra Dunaway-Mariano
Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme A catalyzed by 4-chlorobenzoyl-coenzyme A dehalogenase.
Biochemistry 2002;41(23):7453-63.
2002: Zhihao Zhuang; Feng Song; Brian M Martin; Debra Dunaway-Mariano
The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis.
FEBS letters 2002;516(1-3):161-3.
2002: Andrzej Lewandowicz; Juliusz Rudzinski; Lusong Luo; Debra Dunaway-Mariano; Piotr Paneth
Determination of the chlorine kinetic isotope effect on the 4-chlorobenzoyl-CoA dehalogenase-catalyzed nucleophilic aromatic substitution.
Archives of biochemistry and biophysics 2002;398(2):249-52.
2002: Sushmita D Lahiri; Guofeng Zhang; Peter Radstrom; Debra Dunaway-Mariano; Karen N Allen
Crystallization and preliminary X-ray diffraction studies of beta-phosphoglucomutase from Lactococcus lactus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 2):324-6.
2002: Osnat Herzberg; Celia C H Chen; Sijiu Liu; Aleksandra Tempczyk; Andrew Howard; Min Wei; Dongmei Ye; Debra Dunaway-Mariano
Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis.
Biochemistry 2002;41(3):780-7.
2001: Lusong Luo; Kimberly Taylor; H Xiang; Yansheng Wei; Wenhai Zhang; Debra Dunaway-Mariano
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
Biochemistry 2001;40(51):15684-92.
2001: Wenhai Zhang; Yansheng Wei; Lusong Luo; Kimberly Taylor; G Yang; Debra Dunaway-Mariano; Matthew M Benning; Hazel M Holden
Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis.
Biochemistry 2001;40(45):13474-82.
2001: M Wei; Dongmei Ye; Debra Dunaway-Mariano
Investigation of the role of the domain linkers in separate site catalysis by Clostridium symbiosum pyruvate phosphate dikinase.
Biochemistry 2001;40(45):13466-73.
2001: Dongmei Ye; M Wei; M McGuire; K Huang; Geeta Kapadia; Osnat Herzberg; Brian M Martin; Debra Dunaway-Mariano
Investigation of the catalytic site within the ATP-grasp domain of Clostridium symbiosum pyruvate phosphate dikinase.
The Journal of biological chemistry 2001;276(40):37630-9.
2000: M Wei; Z Li; Dongmei Ye; Osnat Herzberg; Debra Dunaway-Mariano
Identification of domain-domain docking sites within Clostridium symbiosum pyruvate phosphate dikinase by amino acid replacement.
The Journal of biological chemistry 2000;275(52):41156-65.
2000: Marc C Morais; Wenhai Zhang; Angela S Baker; Guofeng Zhang; Debra Dunaway-Mariano; Karen N Allen
The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily.
Biochemistry 2000;39(34):10385-96.
2000: Marc C Morais; Angela S Baker; Debra Dunaway-Mariano; Karen N Allen
Crystallization and preliminary crystallographic analysis of phosphonoacetaldehyde hydrolase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 2):206-9.
1999: Y Jia; Zhibing Lu; K Huang; Osnat Herzberg; Debra Dunaway-Mariano
Insight into the mechanism of phosphoenolpyruvate mutase catalysis derived from site-directed mutagenesis studies of active site residues.
Biochemistry 1999;38(43):14165-73.
1999: H Xiang; Lusong Luo; Kimberly Taylor; Debra Dunaway-Mariano
Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template.
Biochemistry 1999;38(24):7638-52.
1999: K Huang; Z Li; Yong Jia; Debra Dunaway-Mariano; Osnat Herzberg
Helix swapping between two alpha/beta barrels: crystal structure of phosphoenolpyruvate mutase with bound Mg(2+)-oxalate.
Structure (London, England : 1993) 1999;7(5):539-48.
1999: H Xiang; Jian Dong; Paul R Carey; Debra Dunaway-Mariano
Product catalyzes the deamidation of D145N dehalogenase to produce the wild-type enzyme.
Biochemistry 1999;38(13):4207-13.
1999: Jian Dong; H Xiang; Lusong Luo; Debra Dunaway-Mariano; Paul R Carey
Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group.
Biochemistry 1999;38(13):4198-206.
1999: Debra Dunaway-Mariano
Intermediates and energetics in pyruvate phosphate dikinase.
Methods in enzymology 1999;308():149-76.
1998: Matthew M Benning; Gary E Wesenberg; R Liu; K L Taylor; Debra Dunaway-Mariano; Hazel M Holden
The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3.
The Journal of biological chemistry 1998;273(50):33572-9.
1998: M McGuire; K Huang; Geeta Kapadia; Osnat Herzberg; Debra Dunaway-Mariano
Location of the phosphate binding site within Clostridium symbiosum pyruvate phosphate dikinase.
Biochemistry 1998;37(39):13463-74.
1998: Angela S Baker; M J Ciocci; W W Metcalf; J Kim; Patricia C Babbitt; B L Wanner; Brian M Martin; Debra Dunaway-Mariano
Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis.
Biochemistry 1998;37(26):9305-15.
1998: A Kim; J Kim; Brian M Martin; Debra Dunaway-Mariano
Isolation and characterization of the carbon-phosphorus bond-forming enzyme phosphoenolpyruvate mutase from the mollusk Mytilus edulis.
The Journal of biological chemistry 1998;273(8):4443-8.
1997: K H Chang; H Xiang; Debra Dunaway-Mariano
Acyl-adenylate motif of the acyl-adenylate/thioester-forming enzyme superfamily: a site-directed mutagenesis study with the Pseudomonas sp. strain CBS3 4-chlorobenzoate:coenzyme A ligase.
Biochemistry 1997;36(50):15650-9.
1997: J Clarkson; P J Tonge; K L Taylor; Debra Dunaway-Mariano; Paul R Carey
Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.
Biochemistry 1997;36(33):10192-9.
1997: K L Taylor; H Xiang; R Q Liu; G Yang; Debra Dunaway-Mariano
Investigation of substrate activation by 4-chlorobenzoyl-coenzyme A dehalogenase.
Biochemistry 1997;36(6):1349-61.
1996: K H Chang; Debra Dunaway-Mariano
Determination of the chemical pathway for 4-chlorobenzoate:coenzyme A ligase catalysis.
Biochemistry 1996;35(41):13478-84.
1996: G Yang; R Q Liu; K L Taylor; H Xiang; J Price; Debra Dunaway-Mariano
Identification of active site residues essential to 4-chlorobenzoyl-coenzyme A dehalogenase catalysis by chemical modification and site directed mutagenesis.
Biochemistry 1996;35(33):10879-85.
1996: M McGuire; L J Carroll; L Yankie; S H Thrall; Debra Dunaway-Mariano; Osnat Herzberg; B Jayaram; B H Haley
Determination of the nucleotide binding site within Clostridium symbiosum pyruvate phosphate dikinase by photoaffinity labeling, site-directed mutagenesis, and structural analysis.
Biochemistry 1996;35(26):8544-52.
1996: Matthew M Benning; K L Taylor; G Yang; H Xiang; Gary E Wesenberg; Debra Dunaway-Mariano; Hazel M Holden
Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation.
Biochemistry 1996;35(25):8103-9.
1996: J Kim; Debra Dunaway-Mariano
Phosphoenolpyruvate mutase catalysis of phosphoryl transfer in phosphoenolpyruvate: kinetics and mechanism of phosphorus-carbon bond formation.
Biochemistry 1996;35(14):4628-35.
1996: Osnat Herzberg; Celia C H Chen; Geeta Kapadia; M McGuire; L J Carroll; S J Noh; Debra Dunaway-Mariano
Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2652-7.
1995: K L Taylor; R Q Liu; P H Liang; J Price; Debra Dunaway-Mariano; Peter J Tonge; J Clarkson; Paul R Carey
Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman, and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.
Biochemistry 1995;34(42):13881-8.
1995: Y Xu; M McGuire; Debra Dunaway-Mariano; B M Martin
Separate site catalysis by pyruvate phosphate dikinase as revealed by deletion mutants.
Biochemistry 1995;34(7):2195-202.
1995: L Yankie; Y Xu; Debra Dunaway-Mariano
Location of the catalytic site for phosphoenolpyruvate formation within the primary structure of Clostridium symbiosum pyruvate phosphate dikinase. 2. Site-directed mutagenesis of an essential arginine contained within an apparent P-loop.
Biochemistry 1995;34(7):2188-94.
1995: Y Xu; L Yankie; L Shen; Y S Jung; P S Mariano; Debra Dunaway-Mariano; B M Martin
Location of the catalytic site for phosphoenolpyruvate formation within the primary structure of Clostridium symbiosum pyruvate phosphate dikinase. 1. Identification of an essential cysteine by chemical modification with [1-14C]bromopyruvate and site-directed mutagenesis.
Biochemistry 1995;34(7):2181-7.
1994: Debra Dunaway-Mariano; Patricia C Babbitt
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
Biodegradation 1994;5(3-4):259-76.
1994: G Yang; P H Liang; Debra Dunaway-Mariano
Evidence for nucleophilic catalysis in the aromatic substitution reaction catalyzed by (4-chlorobenzoyl)coenzyme A dehalogenase.
Biochemistry 1994;33(28):8527-31.
1994: L J Carroll; Y Xu; S H Thrall; B M Martin; Debra Dunaway-Mariano
Substrate binding domains in pyruvate phosphate dikinase.
Biochemistry 1994;33(5):1134-42.
1994: S H Thrall; Debra Dunaway-Mariano
Kinetic evidence for separate site catalysis by pyruvate phosphate dikinase.
Biochemistry 1994;33(5):1103-7.
1994: Andrew F Mehl; Y Xu; Debra Dunaway-Mariano
Energetics of pyruvate phosphate dikinase catalysis.
Biochemistry 1994;33(5):1093-102.
1993: P H Liang; G Yang; Debra Dunaway-Mariano
Specificity of 4-chlorobenzoyl coenzyme A dehalogenase catalyzed dehalogenation of halogenated aromatics.
Biochemistry 1993;32(45):12245-50.
1993: Z Lu; A L Shorter; Debra Dunaway-Mariano
Investigations of kinase substrate specificity with aqua Rh(III) complexes of adenosine 5'-triphosphate.
Biochemistry 1993;32(9):2378-85.
1993: S H Thrall; Andrew F Mehl; L J Carroll; Debra Dunaway-Mariano
Characterization of the covalent enzyme intermediates formed during pyruvate phosphate dikinase catalysis.
Biochemistry 1993;32(7):1803-9.
1992: D B Olsen; T W Hepburn; S L Lee; B M Martin; P S Mariano; Debra Dunaway-Mariano
Investigation of the substrate binding and catalytic groups of the P-C bond cleaving enzyme, phosphonoacetaldehyde hydrolase.
Archives of biochemistry and biophysics 1992;296(1):144-51.
1992: K H Chang; P H Liang; W Beck; J D Scholten; Debra Dunaway-Mariano
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
Biochemistry 1992;31(24):5605-10.
1992: Patricia C Babbitt; G L Kenyon; B M Martin; H Charest; M Slyvestre; J D Scholten; K H Chang; P H Liang; Debra Dunaway-Mariano
Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases.
Biochemistry 1992;31(24):5594-604.
1991: J D Scholten; K H Chang; Patricia C Babbitt; H Charest; Michel Sylvestre; Debra Dunaway-Mariano
Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic.
Science (New York, N.Y.) 1991;253(5016):182-5.
1990: D J Pocalyko; L J Carroll; B M Martin; Patricia C Babbitt; Debra Dunaway-Mariano
Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs.
Biochemistry 1990;29(48):10757-65.
1990: L J Carroll; Debra Dunaway-Mariano; C M Smith; R Chollet
Determination of the catalytic pathway of C4-leaf pyruvate, orthophosphate dikinase from maize.
FEBS letters 1990;274(1-2):178-80.
1990: E D Bowman; M S McQueney; J D Scholten; Debra Dunaway-Mariano
Purification and characterization of the Tetrahymena pyriformis P-C bond forming enzyme phosphoenolpyruvate phosphomutase.
Biochemistry 1990;29(30):7059-63.
1989: S Hanley-Trawick; M E Carpen; Debra Dunaway-Mariano; Peter L Pedersen; J Hullihen
Investigation of the substrate structure and metal cofactor requirements of the rat liver mitochondrial ATP synthase/ATPase complex.
Archives of biochemistry and biophysics 1989;268(1):116-23.
1988: R J Barry; E Bowman; M McQueney; Debra Dunaway-Mariano
Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis.
Biochemical and biophysical research communications 1988;153(1):177-82.
1988: D B Olsen; T W Hepburn; M Moos; P S Mariano; Debra Dunaway-Mariano
Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue.
Biochemistry 1988;27(6):2229-34.
1988: H C Wang; L Ciskanik; Debra Dunaway-Mariano; W von der Saal; J J Villafranca
Investigations of the partial reactions catalyzed by pyruvate phosphate dikinase.
Biochemistry 1988;27(2):625-33.
1987: R J Barry; Debra Dunaway-Mariano
The kinetic mechanism of yeast inorganic pyrophosphatase.
Archives of biochemistry and biophysics 1987;259(1):196-203.
1987: A L Shorter; T P Haromy; T Scalzo-Brush; W B Knight; Debra Dunaway-Mariano; Muttaiya Sundaralingam
Structural and biochemical properties of bidentate tetraaquarhodium(III) complexes of inorganic pyrophosphate and adenosine 5'-diphosphate.
Biochemistry 1987;26(7):2060-6.
1986: I Lin; W B Knight; A Hsueh; Debra Dunaway-Mariano
Investigation of the regiospecificity and stereospecificity of proton transfer in the yeast inorganic pyrophosphatase catalyzed reaction.
Biochemistry 1986;25(16):4688-92.
1986: L Ciskanik; Debra Dunaway-Mariano
Inhibition and inactivation of pyruvate phosphate dikinase with Cr(III) complexes of adenosine 5'-triphosphate and inorganic pyrophosphate.
Journal of enzyme inhibition 1986;1(2):113-25.
1984: W B Knight; Debra Dunaway-Mariano; S C Ransom; J J Villafranca
Investigations of the metal ion-binding sites of yeast inorganic pyrophosphatase.
The Journal of biological chemistry 1984;259(5):2886-95.
1984: S J Ting; Debra Dunaway-Mariano
Investigation of the role of the substrate metal ion in the yeast inorganic pyrophosphatase reaction.
FEBS letters 1984;165(2):251-3.
1983: W B Knight; S J Ting; S Chuang; Debra Dunaway-Mariano; T Haromy; Muttaiya Sundaralingam
Yeast inorganic pyrophosphatase substrate recognition.
Archives of biochemistry and biophysics 1983;227(1):302-9.
1982: T P Haromy; W B Knight; Debra Dunaway-Mariano; Muttaiya Sundaralingam
X-ray crystallographic and nuclear magnetic resonance spectral studies of the products from the yeast inorganic pyrophosphatase-Co(NH3)4PP reaction. Investigation of the pyrophosphatase reaction mechanism.
Biochemistry 1982;21(26):6950-6.
1981: W B Knight; S W Fitts; Debra Dunaway-Mariano
Investigation of the catalytic mechanism of yeast inorganic pyrophosphatase.
Biochemistry 1981;20(14):4079-86.