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Debra Dunaway-Mariano

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Phenomena

Catalysis

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Chemicals & Drugs

Procedures

X-Ray Crystallography

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Amino Acid Sequence

Physiology

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Co-Publications
Name
28
Herzberg, Osnat
25
Allen, Karen
14
Zhang, Guofeng
10
Mariano, Patrick
8
Lu, Xuefeng
8
Galkin, Andrey
7
Dai, Jianying
7
Martin, Brian
7
Luo, Lusong
6
Zhuang, Zhihao
6
Carey, Paul
6
Howard, Andrew
5
Kulakova, Liudmila
5
Lahiri, Sushmita
5
Holden, Hazel

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Publications

TOP 3
Li Zhili; Song Feng; Zhuang Zhihao; Dunaway-Mariano Debra; Anderson Karen S
Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry.
Li Zhimin; Kulakova Liudmila; Li Ling; Galkin Andrey; Zhao Zhiming; Nash Theodore E; Mariano Patrick S; Herzberg Osnat; Dunaway-Mariano Debra
Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia.
Galkin Andrey; Kulakova Liudmila; Wu Rui; Gong Maozhen; Dunaway-Mariano Debra; Herzberg Osnat
X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia.

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All Publications

2009: Li Zhili; Song Feng; Zhuang Zhihao; Dunaway-Mariano Debra; Anderson Karen S
Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry.
Analytical biochemistry 2009;394(2):209-16.
2009: Li Zhimin; Kulakova Liudmila; Li Ling; Galkin Andrey; Zhao Zhiming; Nash Theodore E; Mariano Patrick S; Herzberg Osnat; Dunaway-Mariano Debra
Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia.
Bioorganic chemistry 2009;37(5):149-61.
2009: Galkin Andrey; Kulakova Liudmila; Wu Rui; Gong Maozhen; Dunaway-Mariano Debra; Herzberg Osnat
X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia.
Proteins 2009;76(4):1049-53.
2009: Zhao Hong; Martin Brian M; Bisoffi Marco; Dunaway-Mariano Debra
The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.
Biochemistry 2009;48(24):5507-9.
2009: Wu Rui; Reger Albert S; Lu Xuefeng; Gulick Andrew M; Dunaway-Mariano Debra
The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase.
Biochemistry 2009;48(19):4115-25.
2009: Galkin Andrey; Li Zhimin; Li Ling; Kulakova Liudmila; Pal Lipika R; Dunaway-Mariano Debra; Herzberg Osnat
Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.
Biochemistry 2009;48(14):3186-96.
2009: Dai Jianying; Finci Lorenzo; Zhang Chunchun; Lahiri Sushmita; Zhang Guofeng; Peisach Ezra; Allen Karen N; Dunaway-Mariano Debra
Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.
Biochemistry 2009;48(9):1984-95.
2009: Cao Jian; Xu Hang; Zhao Hong; Gong Weimin; Dunaway-Mariano Debra
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis.
Biochemistry 2009;48(6):1293-304.
2009: Narayanan Buvaneswari; Niu Weiling; Joosten Henk-Jan; Li Zhimin; Kuipers Remko K P; Schaap Peter J; Dunaway-Mariano Debra; Herzberg Osnat
Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member.
Journal of molecular biology 2009;386(2):486-503.
2009: Chen Danqi; Wu Rui; Bryan Tyrel L; Dunaway-Mariano Debra
In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH.
Biochemistry 2009;48(3):511-3.
2009: Lu Zhibing; Wang Liangbing; Dunaway-Mariano Debra; Allen Karen N
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.
The Journal of biological chemistry 2009;284(2):1224-33.
2008: Dunaway-Mariano Debra
Enzyme function discovery.
Structure (London, England : 1993) 2008;16(11):1599-600.
2008: Wang Liangbing; Lu Zhibing; Allen Karen N; Mariano Patrick S; Dunaway-Mariano Debra
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
Chemistry & biology 2008;15(9):893-7.
2008: Wu Rui; Cao Jian; Lu Xuefeng; Reger Albert S; Gulick Andrew M; Dunaway-Mariano Debra
Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis.
Biochemistry 2008;47(31):8026-39.
2008: Reger Albert S; Wu Rui; Dunaway-Mariano Debra; Gulick Andrew M
Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase.
Biochemistry 2008;47(31):8016-25.
2008: Lu Zhibing; Dunaway-Mariano Debra; Allen Karen N
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5687-92.
2008: Li Ling; Li Zhimin; Wang Canhui; Xu Dingguo; Mariano Patrick S; Guo Hua; Dunaway-Mariano Debra
The electrostatic driving force for nucleophilic catalysis in L-arginine deiminase: a combined experimental and theoretical study.
Biochemistry 2008;47(16):4721-32.
2008: Willis Mark A; Zhuang Zhihao; Song Feng; Howard Andrew; Dunaway-Mariano Debra; Herzberg Osnat
Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase.
Biochemistry 2008;47(9):2797-805.
2008: Zhuang Zhihao; Song Feng; Zhao Hong; Li Ling; Cao Jian; Eisenstein Edward; Herzberg Osnat; Dunaway-Mariano Debra
Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA.
Biochemistry 2008;47(9):2789-96.
2008: Li Ling; Li Zhimin; Chen Danqi; Lu Xuefeng; Feng Xiaohua; Wright Elizabeth C; Solberg Nathan O; Dunaway-Mariano Debra; Mariano Patrick S; Galkin Andrey; Kulakova Liudmila; Herzberg Osnat; Green-Church Kari B; Zhang Liwen
Inactivation of microbial arginine deiminases by L-canavanine.
Journal of the American Chemical Society 2008;130(6):1918-31.
2008: Narayanan Buvaneswari C; Niu Weiling; Han Ying; Zou Jiwen; Mariano Patrick S; Dunaway-Mariano Debra; Herzberg Osnat
Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily.
Biochemistry 2008;47(1):167-82.
2008: Joosten Henk-Jan; Han Ying; Niu Weiling; Vervoort Jacques; Dunaway-Mariano Debra; Schaap Peter J
Identification of fungal oxaloacetate hydrolyase within the isocitrate lyase/PEP mutase enzyme superfamily using a sequence marker-based method.
Proteins 2008;70(1):157-66.
2008: Peisach Ezra; Wang Liangbing; Burroughs A Maxwell; Aravind L; Dunaway-Mariano Debra; Allen Karen N
The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function.
Proteins 2008;70(1):197-207.
2007: Lim Kap; Read Randy J; Chen Celia C H; Tempczyk Aleksandra; Wei Min; Ye Dongmei; Wu Chun; Dunaway-Mariano Debra; Herzberg Osnat
Swiveling domain mechanism in pyruvate phosphate dikinase.
Biochemistry 2007;46(51):14845-53.
2007: Wu Rui; Reger Albert S; Cao Jian; Gulick Andrew M; Dunaway-Mariano Debra
Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range.
Biochemistry 2007;46(50):14487-99.
2007: Han Ying; Joosten Henk-Jan; Niu Weiling; Zhao Zhiming; Mariano Patrick S; McCalman Melisa; van Kan Jan; Schaap Peter J; Dunaway-Mariano Debra
Oxaloacetate hydrolase, the C-C bond lyase of oxalate secreting fungi.
The Journal of biological chemistry 2007;282(13):9581-90.
2007: Galkin Andrey; Kulakova Liudmila; Melamud Eugene; Li Ling; Wu Chun; Mariano Patrick; Dunaway-Mariano Debra; Nash Theodore E; Herzberg Osnat
Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia.
The Journal of biological chemistry 2007;282(7):4859-67.
2007: Song Feng; Zhuang Zhihao; Dunaway-Mariano Debra
Structure-activity analysis of base and enzyme-catalyzed 4-hydroxybenzoyl coenzyme A hydrolysis.
Bioorganic chemistry 2007;35(1):1-10.
2006: Lahiri Sushmita D; Zhang Guofeng; Dunaway-Mariano Debra; Allen Karen N
Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.
Bioorganic chemistry 2006;34(6):394-409.
2006: Cheng Zhongjun; Song Feng; Shan Xiaoyue; Wei Zhiyi; Wang Yanli; Dunaway-Mariano Debra; Gong Weimin
Crystal structure of human thioesterase superfamily member 2.
Biochemical and biophysical research communications 2006;349(1):172-7.
2006: Chen Celia C H; Han Ying; Niu Weiling; Kulakova Anna N; Howard Andrew; Quinn John P; Dunaway-Mariano Debra; Herzberg Osnat
Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily.
Biochemistry 2006;45(38):11491-504.
2006: Burroughs A Maxwell; Allen Karen N; Dunaway-Mariano Debra; Aravind L
Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes.
Journal of molecular biology 2006;361(5):1003-34.
2006: Dai Jianying; Wang Liangbing; Allen Karen N; Radstrom Peter; Dunaway-Mariano Debra
Conformational cycling in beta-phosphoglucomutase catalysis: reorientation of the beta-D-glucose 1,6-(Bis)phosphate intermediate.
Biochemistry 2006;45(25):7818-24.
2006: Silvaggi Nicholas R; Zhang Chunchun; Lu Zhibing; Dai Jianying; Dunaway-Mariano Debra; Allen Karen N
The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a.
The Journal of biological chemistry 2006;281(21):14918-26.
2006: Song Feng; Zhuang Zhihao; Finci Lorenzo; Dunaway-Mariano Debra; Kniewel Ryan; Buglino John A; Solorzano Veronica; Wu Jin; Lima Christopher D
Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI.
The Journal of biological chemistry 2006;281(16):11028-38.
2006: Lin Ying; Lusin Jacqueline D; Ye Dongmei; Dunaway-Mariano Debra; Ames James B
Examination of the structure, stability, and catalytic potential in the engineered phosphoryl carrier domain of pyruvate phosphate dikinase.
Biochemistry 2006;45(6):1702-11.
2006: Tremblay Lee W; Dunaway-Mariano Debra; Allen Karen N
Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily.
Biochemistry 2006;45(4):1183-93.
2006: Lu Xuefeng; Li Ling; Wu Rui; Feng Xiaohua; Li Zhimin; Yang Heyi; Wang Canhui; Guo Hua; Galkin Andrey; Herzberg Osnat; Mariano Patrick S; Martin Brian M; Dunaway-Mariano Debra
Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function.
Biochemistry 2006;45(4):1162-72.
2006: Wu Jingbo; Xu Dingguo; Lu Xuefeng; Wang Canhui; Guo Hua; Dunaway-Mariano Debra
Contributions of long-range electrostatic interactions to 4-chlorobenzoyl-CoA dehalogenase catalysis: a combined theoretical and experimental study.
Biochemistry 2006;45(1):102-12.
2005: Teplyakov Alexey; Liu Sijiu; Lu Zhibing; Howard Andrew; Dunaway-Mariano Debra; Herzberg Osnat
Crystal structure of the petal death protein from carnation flower.
Biochemistry 2005;44(50):16377-84.
2005: Lu Zhibing; Feng Xiaohua; Song Ling; Han Ying; Kim Alexander; Herzberg Osnat; Woodson William R; Martin Brian M; Mariano Patrick S; Dunaway-Mariano Debra
Diversity of function in the isocitrate lyase enzyme superfamily: the Dianthus caryophyllus petal death protein cleaves alpha-keto and alpha-hydroxycarboxylic acids.
Biochemistry 2005;44(50):16365-76.
2005: Lu Xuefeng; Li Ling; Feng Xiaohua; Wu Yan; Dunaway-Mariano Debra; Engen John R; Mariano Patrick S
L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase.
Journal of the American Chemical Society 2005;127(47):16412-3.
2005: Galkin Andrey; Lu Xuefeng; Dunaway-Mariano Debra; Herzberg Osnat
Crystal structures representing the Michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase.
The Journal of biological chemistry 2005;280(40):34080-7.
2005: Zhang Guofeng; Dai Jianying; Wang Liangbing; Dunaway-Mariano Debra; Tremblay Lee W; Allen Karen N
Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis.
Biochemistry 2005;44(27):9404-16.
2005: Lu Zhibing; Dunaway-Mariano Debra; Allen Karen N
HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.
Biochemistry 2005;44(24):8684-96.
2005: Willis Mark A; Song Feng; Zhuang Zhihao; Krajewski Wojciech; Chalamasetty Vani Rao; Reddy Prasad; Howard Andrew; Dunaway-Mariano Debra; Herzberg Osnat
Structure of YciI from Haemophilus influenzae (HI0828) reveals a ferredoxin-like alpha/beta-fold with a histidine/aspartate centered catalytic site.
Proteins 2005;59(3):648-52.
2005: Tremblay Lee W; Zhang Guofeng; Dai Jianying; Dunaway-Mariano Debra; Allen Karen N
Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase.
Journal of the American Chemical Society 2005;127(15):5298-9.
2005: Liu Sijiu; Lu Zhibing; Han Yin; Melamud Eugene; Dunaway-Mariano Debra; Herzberg Osnat
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution.
Biochemistry 2005;44(8):2949-62.
2004: Xu Dingguo; Wei Yanseng; Wu Jingbo; Dunaway-Mariano Debra; Guo Hua; Cui Qiang; Gao Jiali
QM/MM studies of the enzyme-catalyzed dechlorination of 4-chlorobenzoyl-CoA provide insight into reaction energetics.
Journal of the American Chemical Society 2004;126(42):13649-58.
2004: Peisach Ezra; Selengut Jeremy D; Dunaway-Mariano Debra; Allen Karen N
X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily.
Biochemistry 2004;43(40):12770-9.
2004: Allen Karen N; Dunaway-Mariano Debra
Phosphoryl group transfer: evolution of a catalytic scaffold.
Trends in biochemical sciences 2004;29(9):495-503.
2004: Gulick Andrew M; Lu Xuefeng; Dunaway-Mariano Debra
Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states.
Biochemistry 2004;43(27):8670-9.
2004: Lu Xuefeng; Galkin Andrey; Herzberg Osnat; Dunaway-Mariano Debra
Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis.
Journal of the American Chemical Society 2004;126(17):5374-5.
2004: Zhang Guofeng; Morais Marc C; Dai Jianying; Zhang Wenhai; Dunaway-Mariano Debra; Allen Karen N
Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily.
Biochemistry 2004;43(17):4990-7.
2004: Liu Sijiu; Lu Zhibing; Han Ying; Jia Yong; Howard Andrew; Dunaway-Mariano Debra; Herzberg Osnat
Conformational flexibility of PEP mutase.
Biochemistry 2004;43(15):4447-53.
2004: Lahiri Sushmita D; Zhang Guofeng; Dai Jianying; Dunaway-Mariano Debra; Allen Karen N
Analysis of the substrate specificity loop of the HAD superfamily cap domain.
Biochemistry 2004;43(10):2812-20.
2004: Morais Marc C; Zhang Guofeng; Zhang Wenhai; Olsen David B; Dunaway-Mariano Debra; Allen Karen N
X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis.
The Journal of biological chemistry 2004;279(10):9353-61.
2004: Zhuang Zhihao; Song Feng; Takami Hideto; Dunaway-Mariano Debra
The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase.
Journal of bacteriology 2004;186(2):393-9.
2003: Zhang Guofeng; Allen Karen N; Dunaway-Mariano Debra
Enzymatic synthesis of radiolabeled phosphonoacetaldehyde.
Analytical biochemistry 2003;322(2):233-7.
2003: Thoden James B; Zhuang Zhihao; Dunaway-Mariano Debra; Holden Hazel M
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU.
The Journal of biological chemistry 2003;278(44):43709-16.
2003: Zhang Guofeng; Dai Jiaying; Lu Zhibing; Dunaway-Mariano Debra
The phosphonopyruvate decarboxylase from Bacteroides fragilis.
The Journal of biological chemistry 2003;278(42):41302-8.
2003: Dong Jian; Lu Xuefeng; Wei Yansheng; Luo Lusong; Dunaway-Mariano Debra; Carey Paul R
The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation.
Biochemistry 2003;42(31):9482-90.
2003: Zhuang Zhihao; Gartemann Karl-Heinz; Eichenlaub Rudolf; Dunaway-Mariano Debra
Characterization of the 4-hydroxybenzoyl-coenzyme A thioesterase from Arthrobacter sp. strain SU.
Applied and environmental microbiology 2003;69(5):2707-11.
2003: Lahiri Sushmita D; Zhang Guofeng; Dunaway-Mariano Debra; Allen Karen N
The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction.
Science (New York, N.Y.) 2003;299(5615):2067-71.
2002: Zhang Guofeng; Mazurkie Andrew S; Dunaway-Mariano Debra; Allen Karen N
Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis.
Biochemistry 2002;41(45):13370-7.
2002: Zhuang Zhihao; Song Feng; Zhang Wenhai; Taylor Kimberly; Archambault Angela; Dunaway-Mariano Debra; Dong Jian; Carey Paul R
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site.
Biochemistry 2002;41(37):11152-60.
2002: Liu Sijiu; Lu Zhibing; Jia Yong; Dunaway-Mariano Debra; Herzberg Osnat
Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants.
Biochemistry 2002;41(32):10270-6.
2002: Kim Alexander D; Baker Angela S; Dunaway-Mariano Debra; Metcalf W W; Wanner B L; Martin Brian M
The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway.
Journal of bacteriology 2002;184(15):4134-40.
2002: Lahiri Sushmita D; Zhang Guofeng; Dunaway-Mariano Debra; Allen Karen N
Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis.
Biochemistry 2002;41(26):8351-9.
2002: Thoden James B; Holden Hazel M; Zhuang Zhihao; Dunaway-Mariano Debra
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.
The Journal of biological chemistry 2002;277(30):27468-76.
2002: Dong Jian; Carey Paul R; Wei Yansheng; Luo Lusong; Lu Xuefeng; Liu Rui-Qin; Dunaway-Mariano Debra
Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme A catalyzed by 4-chlorobenzoyl-coenzyme A dehalogenase.
Biochemistry 2002;41(23):7453-63.
2002: Zhuang Zhihao; Song Feng; Martin Brian M; Dunaway-Mariano Debra
The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis.
FEBS letters 2002;516(1-3):161-3.
2002: Lewandowicz Andrzej; Rudzinski Juliusz; Luo Lusong; Dunaway-Mariano Debra; Paneth Piotr
Determination of the chlorine kinetic isotope effect on the 4-chlorobenzoyl-CoA dehalogenase-catalyzed nucleophilic aromatic substitution.
Archives of biochemistry and biophysics 2002;398(2):249-52.
2002: Lahiri Sushmita D; Zhang Guofeng; Radstrom Peter; Dunaway-Mariano Debra; Allen Karen N
Crystallization and preliminary X-ray diffraction studies of beta-phosphoglucomutase from Lactococcus lactus.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 2):324-6.
2002: Herzberg Osnat; Chen Celia C H; Liu Sijiu; Tempczyk Aleksandra; Howard Andrew; Wei Min; Ye Dongmei; Dunaway-Mariano Debra
Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis.
Biochemistry 2002;41(3):780-7.
2001: Luo L; Taylor K L; Xiang H; Wei Y; Zhang W; Dunaway-Mariano D
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
Biochemistry 2001;40(51):15684-92.
2001: Zhang W; Wei Y; Luo L; Taylor K L; Yang G; Dunaway-Mariano D; Benning M M; Holden H M
Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis.
Biochemistry 2001;40(45):13474-82.
2001: Wei M; Ye D; Dunaway-Mariano D
Investigation of the role of the domain linkers in separate site catalysis by Clostridium symbiosum pyruvate phosphate dikinase.
Biochemistry 2001;40(45):13466-73.
2001: Ye D; Wei M; McGuire M; Huang K; Kapadia G; Herzberg O; Martin B M; Dunaway-Mariano D
Investigation of the catalytic site within the ATP-grasp domain of Clostridium symbiosum pyruvate phosphate dikinase.
The Journal of biological chemistry 2001;276(40):37630-9.
2000: Wei M; Li Z; Ye D; Herzberg O; Dunaway-Mariano D
Identification of domain-domain docking sites within Clostridium symbiosum pyruvate phosphate dikinase by amino acid replacement.
The Journal of biological chemistry 2000;275(52):41156-65.
2000: Morais M C; Zhang W; Baker A S; Zhang G; Dunaway-Mariano D; Allen K N
The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily.
Biochemistry 2000;39(34):10385-96.
2000: Morais M C; Baker A S; Dunaway-Mariano D; Allen K N
Crystallization and preliminary crystallographic analysis of phosphonoacetaldehyde hydrolase.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 2):206-9.
1999: Jia Y; Lu Z; Huang K; Herzberg O; Dunaway-Mariano D
Insight into the mechanism of phosphoenolpyruvate mutase catalysis derived from site-directed mutagenesis studies of active site residues.
Biochemistry 1999;38(43):14165-73.
1999: Xiang H; Luo L; Taylor K L; Dunaway-Mariano D
Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template.
Biochemistry 1999;38(24):7638-52.
1999: Huang K; Li Z; Jia Y; Dunaway-Mariano D; Herzberg O
Helix swapping between two alpha/beta barrels: crystal structure of phosphoenolpyruvate mutase with bound Mg(2+)-oxalate.
Structure (London, England : 1993) 1999;7(5):539-48.
1999: Xiang H; Dong J; Carey P R; Dunaway-Mariano D
Product catalyzes the deamidation of D145N dehalogenase to produce the wild-type enzyme.
Biochemistry 1999;38(13):4207-13.
1999: Dong J; Xiang H; Luo L; Dunaway-Mariano D; Carey P R
Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group.
Biochemistry 1999;38(13):4198-206.
1999: Dunaway-Mariano D
Intermediates and energetics in pyruvate phosphate dikinase.
Methods in enzymology 1999;308():149-76.
1998: Benning M M; Wesenberg G; Liu R; Taylor K L; Dunaway-Mariano D; Holden H M
The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3.
The Journal of biological chemistry 1998;273(50):33572-9.
1998: McGuire M; Huang K; Kapadia G; Herzberg O; Dunaway-Mariano D
Location of the phosphate binding site within Clostridium symbiosum pyruvate phosphate dikinase.
Biochemistry 1998;37(39):13463-74.
1998: Baker A S; Ciocci M J; Metcalf W W; Kim J; Babbitt P C; Wanner B L; Martin B M; Dunaway-Mariano D
Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis.
Biochemistry 1998;37(26):9305-15.
1998: Kim A; Kim J; Martin B M; Dunaway-Mariano D
Isolation and characterization of the carbon-phosphorus bond-forming enzyme phosphoenolpyruvate mutase from the mollusk Mytilus edulis.
The Journal of biological chemistry 1998;273(8):4443-8.
1997: Chang K H; Xiang H; Dunaway-Mariano D
Acyl-adenylate motif of the acyl-adenylate/thioester-forming enzyme superfamily: a site-directed mutagenesis study with the Pseudomonas sp. strain CBS3 4-chlorobenzoate:coenzyme A ligase.
Biochemistry 1997;36(50):15650-9.
1997: Clarkson J; Tonge P J; Taylor K L; Dunaway-Mariano D; Carey P R
Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.
Biochemistry 1997;36(33):10192-9.
1997: Taylor K L; Xiang H; Liu R Q; Yang G; Dunaway-Mariano D
Investigation of substrate activation by 4-chlorobenzoyl-coenzyme A dehalogenase.
Biochemistry 1997;36(6):1349-61.
1996: Chang K H; Dunaway-Mariano D
Determination of the chemical pathway for 4-chlorobenzoate:coenzyme A ligase catalysis.
Biochemistry 1996;35(41):13478-84.
1996: Yang G; Liu R Q; Taylor K L; Xiang H; Price J; Dunaway-Mariano D
Identification of active site residues essential to 4-chlorobenzoyl-coenzyme A dehalogenase catalysis by chemical modification and site directed mutagenesis.
Biochemistry 1996;35(33):10879-85.
1996: McGuire M; Carroll L J; Yankie L; Thrall S H; Dunaway-Mariano D; Herzberg O; Jayaram B; Haley B H
Determination of the nucleotide binding site within Clostridium symbiosum pyruvate phosphate dikinase by photoaffinity labeling, site-directed mutagenesis, and structural analysis.
Biochemistry 1996;35(26):8544-52.
1996: Benning M M; Taylor K L; Liu R-Q; Yang G; Xiang H; Wesenberg G; Dunaway-Mariano D; Holden H M
Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation.
Biochemistry 1996;35(25):8103-9.
1996: Herzberg O; Chen C C; Kapadia G; McGuire M; Carroll L J; Noh S J; Dunaway-Mariano D
Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):2652-7.
1996: Kim J; Dunaway-Mariano D
Phosphoenolpyruvate mutase catalysis of phosphoryl transfer in phosphoenolpyruvate: kinetics and mechanism of phosphorus-carbon bond formation.
Biochemistry 1996;35(14):4628-35.
1995: Taylor K L; Liu R Q; Liang P H; Price J; Dunaway-Mariano D; Tonge P J; Clarkson J; Carey P R
Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman, and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.
Biochemistry 1995;34(42):13881-8.
1995: Xu Y; McGuire M; Dunaway-Mariano D; Martin B M
Separate site catalysis by pyruvate phosphate dikinase as revealed by deletion mutants.
Biochemistry 1995;34(7):2195-202.
1995: Yankie L; Xu Y; Dunaway-Mariano D
Location of the catalytic site for phosphoenolpyruvate formation within the primary structure of Clostridium symbiosum pyruvate phosphate dikinase. 2. Site-directed mutagenesis of an essential arginine contained within an apparent P-loop.
Biochemistry 1995;34(7):2188-94.
1995: Xu Y; Yankie L; Shen L; Jung Y S; Mariano P S; Dunaway-Mariano D; Martin B M
Location of the catalytic site for phosphoenolpyruvate formation within the primary structure of Clostridium symbiosum pyruvate phosphate dikinase. 1. Identification of an essential cysteine by chemical modification with [1-14C]bromopyruvate and site-directed mutagenesis.
Biochemistry 1995;34(7):2181-7.
1994: Dunaway-Mariano D; Babbitt P C
On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway.
Biodegradation 1994;5(3-4):259-76.
1994: Yang G; Liang P H; Dunaway-Mariano D
Evidence for nucleophilic catalysis in the aromatic substitution reaction catalyzed by (4-chlorobenzoyl)coenzyme A dehalogenase.
Biochemistry 1994;33(28):8527-31.
1994: Carroll L J; Xu Y; Thrall S H; Martin B M; Dunaway-Mariano D
Substrate binding domains in pyruvate phosphate dikinase.
Biochemistry 1994;33(5):1134-42.
1994: Thrall S H; Dunaway-Mariano D
Kinetic evidence for separate site catalysis by pyruvate phosphate dikinase.
Biochemistry 1994;33(5):1103-7.
1994: Mehl A; Xu Y; Dunaway-Mariano D
Energetics of pyruvate phosphate dikinase catalysis.
Biochemistry 1994;33(5):1093-102.
1993: Liang P H; Yang G; Dunaway-Mariano D
Specificity of 4-chlorobenzoyl coenzyme A dehalogenase catalyzed dehalogenation of halogenated aromatics.
Biochemistry 1993;32(45):12245-50.
1993: Lu Z; Shorter A L; Dunaway-Mariano D
Investigations of kinase substrate specificity with aqua Rh(III) complexes of adenosine 5'-triphosphate.
Biochemistry 1993;32(9):2378-85.
1993: Thrall S H; Mehl A F; Carroll L J; Dunaway-Mariano D
Characterization of the covalent enzyme intermediates formed during pyruvate phosphate dikinase catalysis.
Biochemistry 1993;32(7):1803-9.
1992: Olsen D B; Hepburn T W; Lee S L; Martin B M; Mariano P S; Dunaway-Mariano D
Investigation of the substrate binding and catalytic groups of the P-C bond cleaving enzyme, phosphonoacetaldehyde hydrolase.
Archives of biochemistry and biophysics 1992;296(1):144-51.
1992: Chang K H; Liang P H; Beck W; Scholten J D; Dunaway-Mariano D
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
Biochemistry 1992;31(24):5605-10.
1992: Babbitt P C; Kenyon G L; Martin B M; Charest H; Slyvestre M; Scholten J D; Chang K H; Liang P H; Dunaway-Mariano D
Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases.
Biochemistry 1992;31(24):5594-604.
1991: Scholten J D; Chang K H; Babbitt P C; Charest H; Sylvestre M; Dunaway-Mariano D
Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic.
Science (New York, N.Y.) 1991;253(5016):182-5.
1990: Pocalyko D J; Carroll L J; Martin B M; Babbitt P C; Dunaway-Mariano D
Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs.
Biochemistry 1990;29(48):10757-65.
1990: Carroll L J; Dunaway-Mariano D; Smith C M; Chollet R
Determination of the catalytic pathway of C4-leaf pyruvate, orthophosphate dikinase from maize.
FEBS letters 1990;274(1-2):178-80.
1990: Bowman E D; McQueney M S; Scholten J D; Dunaway-Mariano D
Purification and characterization of the Tetrahymena pyriformis P-C bond forming enzyme phosphoenolpyruvate phosphomutase.
Biochemistry 1990;29(30):7059-63.
1989: Hanley-Trawick S; Carpen M E; Dunaway-Mariano D; Pedersen P L; Hullihen J
Investigation of the substrate structure and metal cofactor requirements of the rat liver mitochondrial ATP synthase/ATPase complex.
Archives of biochemistry and biophysics 1989;268(1):116-23.
1988: Barry R J; Bowman E; McQueney M; Dunaway-Mariano D
Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis.
Biochemical and biophysical research communications 1988;153(1):177-82.
1988: Olsen D B; Hepburn T W; Moos M; Mariano P S; Dunaway-Mariano D
Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue.
Biochemistry 1988;27(6):2229-34.
1988: Wang H C; Ciskanik L; Dunaway-Mariano D; von der Saal W; Villafranca J J
Investigations of the partial reactions catalyzed by pyruvate phosphate dikinase.
Biochemistry 1988;27(2):625-33.
1987: Barry R J; Dunaway-Mariano D
The kinetic mechanism of yeast inorganic pyrophosphatase.
Archives of biochemistry and biophysics 1987;259(1):196-203.
1987: Shorter A L; Haromy T P; Scalzo-Brush T; Knight W B; Dunaway-Mariano D; Sundaralingam M
Structural and biochemical properties of bidentate tetraaquarhodium(III) complexes of inorganic pyrophosphate and adenosine 5'-diphosphate.
Biochemistry 1987;26(7):2060-6.
1986: Lin I; Knight W B; Hsueh A; Dunaway-Mariano D
Investigation of the regiospecificity and stereospecificity of proton transfer in the yeast inorganic pyrophosphatase catalyzed reaction.
Biochemistry 1986;25(16):4688-92.
1986: Ciskanik L; Dunaway-Mariano D
Inhibition and inactivation of pyruvate phosphate dikinase with Cr(III) complexes of adenosine 5'-triphosphate and inorganic pyrophosphate.
Journal of enzyme inhibition 1986;1(2):113-25.
1984: Knight W B; Dunaway-Mariano D; Ransom S C; Villafranca J J
Investigations of the metal ion-binding sites of yeast inorganic pyrophosphatase.
The Journal of biological chemistry 1984;259(5):2886-95.
1984: Ting S J; Dunaway-Mariano D
Investigation of the role of the substrate metal ion in the yeast inorganic pyrophosphatase reaction.
FEBS letters 1984;165(2):251-3.
1983: Knight W B; Ting S J; Chuang S; Dunaway-Mariano D; Haromy T; Sundaralingam M
Yeast inorganic pyrophosphatase substrate recognition.
Archives of biochemistry and biophysics 1983;227(1):302-9.
1982: Haromy T P; Knight W B; Dunaway-Mariano D; Sundaralingam M
X-ray crystallographic and nuclear magnetic resonance spectral studies of the products from the yeast inorganic pyrophosphatase-Co(NH3)4PP reaction. Investigation of the pyrophosphatase reaction mechanism.
Biochemistry 1982;21(26):6950-6.
1981: Knight W B; Fitts S W; Dunaway-Mariano D
Investigation of the catalytic mechanism of yeast inorganic pyrophosphatase.
Biochemistry 1981;20(14):4079-86.

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