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Ruth Duncan

Research Profile

Chemicals & Drugs

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Experimental Melanomas

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Publications

TOP 3
Joseph T Hardwicke; Jeff Hart; Andrea Bell; Ruth Duncan; David W Thomas; Ryan Moseley
The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse.
Samuel P E Deacon; Bojana Apostolovic; Rodrigo J Carbajo; Anne-Kathrin Schott; Konrad Beck; María J Vicent; Antonio Pineda-Lucena; Harm-Anton Klok; Ruth Duncan
Polymer coiled-coil conjugates: potential for development as a new class of therapeutic "molecular switch".
Peter C Griffiths; Renuka Nilmini; Emma Carter; Patrick Dodds; Damien M Murphy; Zeena Khayat; Ettore Lattanzio; Paolo Ferruti; Richard K Heenan; Stephen M King; Ruth Duncan
Interaction of an endosomolytic polyamidoamine ISA23 with vesicles mimicking intracellular membranes: A SANS/EPR study.

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All Publications

2011: Joseph T Hardwicke; Jeff Hart; Andrea Bell; Ruth Duncan; David W Thomas; Ryan Moseley
The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse.
Journal of controlled release : official journal of the Controlled Release Society 2011;152(3):411-7.
2011: Samuel P E Deacon; Bojana Apostolovic; Rodrigo J Carbajo; Anne-Kathrin Schott; Konrad Beck; María J Vicent; Antonio Pineda-Lucena; Harm-Anton Klok; Ruth Duncan
Polymer coiled-coil conjugates: potential for development as a new class of therapeutic "molecular switch".
Biomacromolecules 2011;12(1):19-27.
2010: Peter C Griffiths; Renuka Nilmini; Emma Carter; Patrick Dodds; Damien M Murphy; Zeena Khayat; Ettore Lattanzio; Paolo Ferruti; Richard K Heenan; Stephen M King; Ruth Duncan
Interaction of an endosomolytic polyamidoamine ISA23 with vesicles mimicking intracellular membranes: A SANS/EPR study.
Macromolecular bioscience 2010;10(8):963-73.
2010: Joseph Hardwicke; Ryan Moseley; Phil Stephens; Keith Harding; Ruth Duncan; David W Thomas
Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds.
Molecular pharmaceutics 2010;7(3):699-707.
2010: Elaine L Ferguson; Simon C W Richardson; Ruth Duncan
Studies on the mechanism of action of dextrin-phospholipase A2 and its suitability for use in combination therapy.
Molecular pharmaceutics 2010;7(2):510-21.
2010: Ruth Duncan; María J Vicent
Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities.
Advanced drug delivery reviews 2010;62(2):272-82.
2009: Ruth Duncan
Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt.
Advanced drug delivery reviews 2009;61(13):1131-48.
2009: Elaine L Ferguson; Ruth Duncan
Dextrin-phospholipase A2: synthesis and evaluation as a bioresponsive anticancer conjugate.
Biomacromolecules 2009;10(6):1358-64.
2009: Nathalie Lavignac; Johanna L Nicholls; Paolo Ferruti; Ruth Duncan
Poly(amidoamine) conjugates containing doxorubicin bound via an acid-sensitive linker.
Macromolecular bioscience 2009;9(5):480-7.
2008: Joseph Hardwicke; Elaine L Ferguson; Ryan Moseley; Phil Stephens; David W Thomas; Ruth Duncan
Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair.
Journal of controlled release : official journal of the Controlled Release Society 2008;130(3):275-83.
2008: Simon C W Richardson; Kerri-Lee Wallom; Elaine L Ferguson; Samuel P E Deacon; Matthew W Davies; Alison J Powell; Robert C Piper; Ruth Duncan
The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(1):1-11.
2008: Ruth Duncan; Helena R P Gilbert; Rodrigo J Carbajo; María J Vicent
Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activation.
Biomacromolecules 2008;9(4):1146-54.
2007: Ruth Duncan; Len Seymour
Hiroshi Maeda--defining the pathway to targeted cancer therapy.
Journal of drug targeting 2007;15(7-8):456.
2007: Alison Paul; María J Vicent; Ruth Duncan
Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates.
Biomacromolecules 2007;8(5):1573-9.
2007: Peter C Griffiths; Zeena Khayat; Stephanie Tse; Richard K Heenan; Stephen M King; Ruth Duncan
Studies on the mechanism of interaction of a bioresponsive endosomolytic polyamidoamine with interfaces. 1. Micelles as model surfaces.
Biomacromolecules 2007;8(3):1004-12.
2007: F Philipp Seib; Arwyn T Jones; Ruth Duncan
Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):291-300.
2007: Ruth Duncan
Designing polymer conjugates as lysosomotropic nanomedicines.
Biochemical Society transactions 2007;35(Pt 1):56-60.
2007: Francesca Greco; María J Vicent; Siobhan Gee; Arwyn T Jones; Julia Gee; Robert I Nicholson; Ruth Duncan
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(1):28-39.
2007: Maria Manunta; Lorella Izzo; Ruth Duncan; Arwyn T Jones
Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging.
Journal of drug targeting 2007;15(1):37-50.
2006: Frazia Bettio; Mirta Canevari; Cristina Marzano; Franco Bordin; Andrea Guiotto; F Greco; Ruth Duncan; Francesco M Veronese
Synthesis and biological in vitro evaluation of novel PEG-psoralen conjugates.
Biomacromolecules 2006;7(12):3534-41.
2006: Ruth Duncan
Polymer conjugates as anticancer nanomedicines.
Nature reviews. Cancer 2006;6(9):688-701.
2006: Zeena Khayat; Peter C Griffiths; Isabelle Grillo; Richard K Heenan; Stephen M King; Ruth Duncan
Characterising the size and shape of polyamidoamines in solution as a function of pH using neutron scattering and pulsed-gradient spin-echo NMR.
International journal of pharmaceutics 2006;317(2):175-86.
2006: F Philipp Seib; Arwyn T Jones; Ruth Duncan
Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer - doxorubicin.
Journal of drug targeting 2006;14(6):375-90.
2006: Ruth Duncan; Helmut Ringsdorf; Ronit Satchi-Fainaro
Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities.
Journal of drug targeting 2006;14(6):337-41.
2006: Ruth Duncan
Polymer conjugates for drug targeting. From inspired to inspiration!
Journal of drug targeting 2006;14(6):333-5.
2006: Manuela Berna; Daniele Dalzoppo; Gianfranco Pasut; Maria Manunta; Lorella Izzo; Arwyn T Jones; Ruth Duncan; Francesco M Veronese
Novel monodisperse PEG-dendrons as new tools for targeted drug delivery: synthesis, characterization and cellular uptake.
Biomacromolecules 2006;7(1):146-53.
2006: María J Vicent; Ruth Duncan
Polymer conjugates: nanosized medicines for treating cancer.
Trends in biotechnology 2006;24(1):39-47.
2005: Ruth Duncan; Lorella Izzo
Dendrimer biocompatibility and toxicity.
Advanced drug delivery reviews 2005;57(15):2215-37.
2005: Francesca Greco; María J Vicent; Neal A Penning; Robert I Nicholson; Ruth Duncan
HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines.
Journal of drug targeting 2005;13(8-9):459-70.
2005: Nathalie Lavignac; Michelle Lazenby; Jacopo Franchini; Paolo Ferruti; Ruth Duncan
Synthesis and preliminary evaluation of poly(amidoamine)-melittin conjugates as endosomolytic polymers and/or potential anticancer therapeutics.
International journal of pharmaceutics 2005;300(1-2):102-12.
2005: Ruth Duncan; María J Vicent; Francesca Greco; Robert I Nicholson
Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.
Endocrine-related cancer 2005;12 Suppl 1():S189-99.
2005: Francesco M Veronese; Oddone Schiavon; Gianfranco Pasut; Raniero Mendichi; Lars Andersson; Anders Tsirk; Jayne Ford; Gefei Wu; Samantha Kneller; John Davies; Ruth Duncan
PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity.
Bioconjugate chemistry 2005;16(4):775-84.
2005: María J Vicent; Francesca Greco; Robert I Nicholson; Alison Paul; Peter C Griffiths; Ruth Duncan
Polymer therapeutics designed for a combination therapy of hormone-dependent cancer.
Angewandte Chemie (International ed. in English) 2005;44(26):4061-6.
2005: Lars Andersson; John Davies; Ruth Duncan; Paolo Ferruti; Jayne Ford; Samantha Kneller; Raniero Mendichi; Gianfranco Pasut; Oddone Schiavon; Clive Summerford; Anders Tirk; Francesco M Veronese; Veronica Vincenzi; Gefei Wu
Poly(ethylene glycol)-poly(ester-carbonate) block copolymers carrying PEG-peptidyl-doxorubicin pendant side chains: synthesis and evaluation as anticancer conjugates.
Biomacromolecules 2005;6(2):914-26.
2004: Nathalie Lavignac; Michelle Lazenby; Peli Foka; Beatrice Malgesini; Ilario Verpilio; Paolo Ferruti; Ruth Duncan
Synthesis and endosomolytic properties of poly(amidoamine) block copolymers.
Macromolecular bioscience 2004;4(10):922-9.
2004: Sunil Shaunak; Sharyn Thomas; Elisabetta Gianasi; Antony Godwin; Emma Jones; Ian Teo; Kamiar Mireskandari; Philip J Luthert; Ruth Duncan; Steve Patterson; Peng Khaw; Steve Brocchini
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation.
Nature biotechnology 2004;22(8):977-84.
2004: Peter C Griffiths; Alison Paul; Zeena Khayat; Ka-Wai Wan; Stephen M King; Isabelle Grillo; R Schweins; Paolo Ferruti; Jacopo Franchini; Ruth Duncan
Understanding the mechanism of action of poly(amidoamine)s as endosomolytic polymers: correlation of physicochemical and biological properties.
Biomacromolecules 2004;5(4):1422-7.
2004: Ka-Wai Wan; Beatrice Malgesini; Ilario Verpilio; Paolo Ferruti; Peter C Griffiths; Alison Paul; Anthony C Hann; Ruth Duncan
Poly(amidoamine) salt form: effect on pH-dependent membrane activity and polymer conformation in solution.
Biomacromolecules 2004;5(3):1102-9.
2004: María J Vicent; Sonia Manzanaro; Jesús Angel de la Fuente; Ruth Duncan
HPMA copolymer-1,5-diazaanthraquinone conjugates as novel anticancer therapeutics.
Journal of drug targeting 2004;12(8):503-15.
2004: María J Vicent; Ryan Tomlinson; Steve Brocchini; Ruth Duncan
Polyacetal-diethylstilboestrol: a polymeric drug designed for pH-triggered activation.
Journal of drug targeting 2004;12(8):491-501.
2003: Arwyn T Jones; Mark Gumbleton; Ruth Duncan
Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems.
Advanced drug delivery reviews 2003;55(11):1353-7.
2003: Ryan Tomlinson; Jorge Heller; Steve Brocchini; Ruth Duncan
Polyacetal-doxorubicin conjugates designed for pH-dependent degradation.
Bioconjugate chemistry 2003;14(6):1096-106.
2003: Ronit Satchi-Fainaro; Hanna Hailu; John W Davies; Clive Summerford; Ruth Duncan
PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination.
Bioconjugate chemistry 2003;14(4):797-804.
2003: Maya Thanou; Ruth Duncan
Polymer-protein and polymer-drug conjugates in cancer therapy.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):701-9.
2003: Ruth Duncan
The dawning era of polymer therapeutics.
Nature reviews. Drug discovery 2003;2(5):347-60.
2002: Elisabetta Gianasi; Robert G Buckley; John R Latigo; Mo Wasil; Ruth Duncan
HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation.
Journal of drug targeting 2002;10(7):549-56.
2001: N G Pattrick; S C Richardson; M Casolaro; Paolo Ferruti; Ruth Duncan
Poly(amidoamine)-mediated intracytoplasmic delivery of ricin A-chain and gelonin.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(3):225-32.
2001: D Hreczuk-Hirst; D Chicco; L German; Ruth Duncan
Dextrins as potential carriers for drug targeting: tailored rates of dextrin degradation by introduction of pendant groups.
International journal of pharmaceutics 2001;230(1-2):57-66.
2001: R Satchi; T A Connors; Ruth Duncan
PDEPT: polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combination.
British journal of cancer 2001;85(7):1070-6.
2001: Frances Searle; S Gac-Breton; R Keane; S Dimitrijevic; Steve Brocchini; Edward A Sausville; Ruth Duncan
N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis, in vitro, and preliminary in vivo evaluation.
Bioconjugate chemistry 2001;12(5):711-8.
2001: Ruth Duncan; S Gac-Breton; R Keane; R Musila; Y N Sat; R Satchi; Frances Searle
Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):135-46.
2001: S C Richardson; N G Pattrick; Y K Man; Paolo Ferruti; Ruth Duncan
Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro.
Biomacromolecules 2001;2(3):1023-8.
2000: R Wiwattanapatapee; B Carreño-Gómez; N Malik; Ruth Duncan
Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system?
Pharmaceutical research 2000;17(8):991-8.
2000: N Malik; R Wiwattanapatapee; R Klopsch; K Lorenz; H Frey; J W Weener; E W Meijer; W Paulus; Ruth Duncan
Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):133-48.
1999: N Malik; E G Evagorou; Ruth Duncan
Dendrimer-platinate: a novel approach to cancer chemotherapy.
Anti-cancer drugs 1999;10(8):767-76.
1999: Elisabetta Gianasi; M Wasil; E G Evagorou; A Keddle; G Wilson; Ruth Duncan
HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo.
European journal of cancer (Oxford, England : 1990) 1999;35(6):994-1002.
1999: S C Richardson; H V Kolbe; Ruth Duncan
Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA.
International journal of pharmaceutics 1999;178(2):231-43.
1999: S Richardson; P Ferruti; Ruth Duncan
Poly(amidoamine)s as potential endosomolytic polymers: evaluation in vitro and body distribution in normal and tumour-bearing animals.
Journal of drug targeting 1999;6(6):391-404.
1998: Ruth Duncan; J K Coatsworth; S Burtles
Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymer-doxorubicin (PK1).
Human & experimental toxicology 1998;17(2):93-104.
1997: Ruth Duncan
Drug targeting: where are we now and where are we going?
Journal of drug targeting 1997;5(1):1-4.
1996: M V Pimm; Alan C Perkins; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic human colon carcinoma.
Journal of drug targeting 1996;3(5):385-90.
1996: M V Pimm; Alan C Perkins; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Gamma scintigraphy of the biodistribution of 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in mice with transplanted melanoma and mammary carcinoma.
Journal of drug targeting 1996;3(5):375-83.
1995: T A Connors; Ruth Duncan; Richard J Knox
The chemotherapy of colon cancer.
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1373-8.
1995: Leonard W Seymour; Y Miyamoto; H Maeda; M Brereton; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):766-70.
1994: Leonard W Seymour; Karel Ulbrich; Peter S Steyger; M Brereton; Vladimir Subr; Jirí Strohalm; Ruth Duncan
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.
British journal of cancer 1994;70(4):636-41.
1993: S Woerly; G Maghami; Ruth Duncan; Vladimir Subr; Karel Ulbrich
Synthetic polymer derivatives as substrata for neuronal adhesion and growth.
Brain research bulletin 1993;30(3-4):423-32.
1993: K B O'Hare; Ruth Duncan; Jirí Strohalm; Karel Ulbrich; P Kopeckova
Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma.
Journal of drug targeting 1993;1(3):217-29.
1993: M V Pimm; Alan C Perkins; Ruth Duncan; Karel Ulbrich
Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies.
Journal of drug targeting 1993;1(2):125-31.
1991: Leonard W Seymour; Karel Ulbrich; S R Wedge; I C Hume; Jirí Strohalm; Ruth Duncan
N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
British journal of cancer 1991;63(6):859-66.
1991: S R Wedge; Ruth Duncan; P Kopeckova
Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.
British journal of cancer 1991;63(4):546-9.
1991: T K Yeung; John W Hopewell; R H Simmonds; Leonard W Seymour; Ruth Duncan; O Bellini; M Grandi; F Spreafico; Jirí Strohalm; Karel Ulbrich
Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.
Cancer chemotherapy and pharmacology 1991;29(2):105-11.
1991: Leonard W Seymour; P A Flanagan; A al-Shamkhani; Vladimir Subr; Karel Ulbrich; J Cassidy; Ruth Duncan
Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery.
Selective cancer therapeutics 1991;7(2):59-73.
1990: Leonard W Seymour; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
1990: V Subr; Ruth Duncan; Jindrich Kopecek
Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds.
Journal of biomaterials science. Polymer edition 1990;1(4):261-78.
1989: P A Flanagan; Pavla Kopecková; Jindrich Kopecek; Ruth Duncan
Evaluation of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of transferrin and anti-transferrin receptor antibody conjugates.
Biochimica et biophysica acta 1989;993(1):83-91.
1989: K B O'Hare; I C Hume; L Scarlett; V Chytrý; Pavla Kopecková; Jindrich Kopecek; Ruth Duncan
Effect of galactose on interaction of N-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: preliminary application to an anticancer agent, daunomycin.
Hepatology (Baltimore, Md.) 1989;10(2):207-14.
1989: B Rihova; Martin Bilej; V Vetvicka; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Biomaterials 1989;10(5):335-42.
1989: J Cassidy; Ruth Duncan; G J Morrison; Jirí Strohalm; D Plocova; Jindrich Kopecek; S B Kaye
Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model.
Biochemical pharmacology 1989;38(6):875-9.
1988: Ruth Duncan; Pavla Kopecková; Jirí Strohalm; I C Hume; J B Lloyd; Jindrich Kopecek
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.
British journal of cancer 1988;57(2):147-56.
1987: Leonard W Seymour; Ruth Duncan; Pavla Kopecková; Jindrich Kopecek
Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Cancer treatment reviews 1987;14(3-4):319-27.
1987: Leonard W Seymour; Ruth Duncan; Jirí Strohalm; Jindrich Kopecek
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Journal of biomedical materials research 1987;21(11):1341-58.
1987: Ruth Duncan; P Kopecková-Rejmanová; Jirí Strohalm; I Hume; H C Cable; J Pohl; J B Lloyd; Jindrich Kopecek
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
British journal of cancer 1987;55(2):165-74.
1986: Ruth Duncan; H C Cable; Jirí Strohalm; Jindrich Kopecek
Pinocytic capture and exocytosis of rat immunoglobulin IgG-N-(2-hydroxypropyl)methacrylamide copolymer conjugates by rat visceral yolk sacs cultured in vitro.
Bioscience reports 1986;6(10):869-77.
1986: Ruth Duncan; L C Seymour; L Scarlett; J B Lloyd; P Rejmanová; Jindrich Kopecek
Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats.
Biochimica et biophysica acta 1986;880(1):62-71.
1985: P Rejmanová; Jindrich Kopecek; Ruth Duncan; J B Lloyd
Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers.
Biomaterials 1985;6(1):45-8.
1985: Jindrich Kopecek; P Rejmanová; Ruth Duncan; J B Lloyd
Controlled release of drug model from N-(2-hydroxypropyl)-methacrylamide copolymers.
Annals of the New York Academy of Sciences 1985;446():93-104.
1984: Ruth Duncan; H C Cable; P Rejmanová; Jindrich Kopecek; J B Lloyd
Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers.
Biochimica et biophysica acta 1984;799(1):1-8.
1983: Ruth Duncan; Jindrich Kopecek; P Rejmanová; J B Lloyd
Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues.
Biochimica et biophysica acta 1983;755(3):518-21.
1982: Ruth Duncan; H C Cable; J B Lloyd; P Rejmanová; Jindrich Kopecek
Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases.
Bioscience reports 1982;2(12):1041-6.