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Ben Dunn

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Chemicals & Drugs

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Ben M Dunn
Volume 14 of Current Protein and Peptide Science. Preface.
Xi Huang; Jamie L Kear; James R Rocca; Carlos Simmerling; Angelo M Veloro; Mandy E Blackburn; Jeffery D Carter; Ian Mitchelle S De Vera; Ben M Dunn; Gail E Fanucci
Inhibitor-induced conformational shifts and ligand-exchange dynamics for HIV-1 protease measured by pulsed EPR and NMR spectroscopy.
Ben M Dunn
Protein & peptide letters. Editorial.

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All Publications

2013: Ben M Dunn
Volume 14 of Current Protein and Peptide Science. Preface.
Current protein & peptide science 2013;14(1):1.
2012: Xi Huang; Jamie L Kear; James R Rocca; Carlos Simmerling; Angelo M Veloro; Mandy E Blackburn; Jeffery D Carter; Ian Mitchelle S De Vera; Ben M Dunn; Gail E Fanucci
Inhibitor-induced conformational shifts and ligand-exchange dynamics for HIV-1 protease measured by pulsed EPR and NMR spectroscopy.
The journal of physical chemistry. B 2012;116(49):14235-44.
2012: Ben M Dunn
Protein & peptide letters. Editorial.
Protein and peptide letters 2012;19(6):573-4.
2012: Ahu Demir; Tomozumi Imamichi; Andrew Magis; Raphael M Oguariri; David A Ostrov; Ben M Dunn
Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells.
Antiviral therapy 2012;17(5):883-92.
2011: Mi Li; Krisztina Matúz; Sirilak Namwong; József Tözsér; Ben M Dunn; Nathan E Goldfarb; Alla Gustchina; Alexander Wlodawer
Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
The FEBS journal 2011;278(22):4413-24.
2011: Ben M Dunn
Protein & Peptide Letters. Editorial.
Protein and peptide letters 2011;18(3):219.
2010: Arthur H Robbins; Roxana M Coman; Edith Bracho-Sanchez; Marty A Fernandez; C Taylor Gilliland; Mi Li; Mavis Agbandje-McKenna; Alexander Wlodawer; Ben M Dunn; Robert McKenna
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 3):233-42.
2009: Jamie L Kear; Mandy E Blackburn; Angelo M Veloro; Ben M Dunn; Gail E Fanucci
Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility.
Journal of the American Chemical Society 2009;131(41):14650-1.
2009: Ben M Dunn; Vladimir Uversky
Cryoenzymology: enzyme action in slow motion.
Current protein & peptide science 2009;10(5):408-15.
2009: Sarah K Ho; Elena E Perez; Stephanie L Rose; Roxana M Coman; Amanda C Lowe; Wei Hou; Changxing Ma; Robert M Lawrence; Ben M Dunn; John W Sleasman; Maureen M Goodenow
Genetic determinants in HIV-1 Gag and Env V3 are related to viral response to combination antiretroviral therapy with a protease inhibitor.
AIDS (London, England) 2009;23(13):1631-40.
2009: Kristina M Orrling; Melissa R Marzahn; Hugo Gutierrez de teran; Johan Aqvist; Ben M Dunn; Mats Larhed
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
Bioorganic & medicinal chemistry 2009;17(16):5933-49.
2009: Peng Liu; Melissa R Marzahn; Arthur H Robbins; Hugo Gutierrez de teran; David Rodríguez; Scott H McClung; Stanley M Stevens; Charles A Yowell; John B Dame; Robert McKenna; Ben M Dunn
Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
Biochemistry 2009;48(19):4086-99.
2009: Arthur H Robbins; Ben M Dunn; Mavis Agbandje-McKenna; Robert McKenna
Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 3):294-6.
2008: Sarah K Ho; Roxana M Coman; Joshua C Bunger; Stephanie L Rose; Patricia O'Brien; Isabel Munoz; Ben M Dunn; John W Sleasman; Maureen M Goodenow
Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response.
Virology 2008;378(2):272-81.
2008: Roxana M Coman; Arthur H Robbins; Maureen M Goodenow; Ben M Dunn; Robert McKenna
High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):754-63.
2008: José C Clemente; Arthur Robbins; Paula Graña; M Rita Paleo; Juan F Correa; M Carmen Villaverde; F Javier Sardina; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; Robert McKenna; Ben M Dunn; Fredy Sussman
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
Journal of medicinal chemistry 2008;51(4):852-60.
2008: Roxana M Coman; Arthur H Robbins; Marty A Fernandez; C Taylor Gilliland; Anthony A Sochet; Maureen M Goodenow; Robert McKenna; Ben M Dunn
The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.
Biochemistry 2008;47(2):731-43.
2008: Linda Janka; José C Clemente; N Vaiana; A Sparatore; Sergio Romeo; Ben M Dunn
Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors.
Protein and peptide letters 2008;15(9):868-73.
2008: Ben M Dunn
Protein and peptide letters.
Protein and peptide letters 2008;15(9):866-7.
2008: Ben M Dunn
Editorial. BACE or beta-secretase -a target for drug discovery for treatment of Alzheimer's disease.
Protein and peptide letters 2008;15(2):118.
2007: Rebecca E Moose; José C Clemente; Larry R Jackson; Minh Ngo; Kimberly Wooten; Richard Chang; Antonette Bennett; Sibani Chakraborty; Charles A Yowell; John B Dame; Mavis Agbandje-McKenna; Ben M Dunn
Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.
Biochemistry 2007;46(49):14198-205.
2007: Roxana M Coman; Arthur Robbins; Maureen M Goodenow; Robert McKenna; Ben M Dunn
Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 4):320-3.
2006: Hugo Gutierrez de teran; Martin Nervall; Ben M Dunn; José C Clemente; Johan Aqvist
Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor.
FEBS letters 2006;580(25):5910-6.
2006: Ayumi Okubo; Mi Li; Masako Ashida; Hiroshi Oyama; Alla Gustchina; Kohei Oda; Ben M Dunn; Alexander Wlodawer; Toru Nakayama
Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
The FEBS journal 2006;273(11):2563-76.
2006: José C Clemente; Roxana M Coman; Michele M Thiaville; Linda K Janka; Jennifer A Jeung; Sarawut Nukoolkarn; Lakshmanan Govindasamy; Mavis Agbandje-McKenna; Robert McKenna; Wichet Leelamanit; Maureen M Goodenow; Ben M Dunn
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry 2006;45(17):5468-77.
2006: Karolina Ersmark; Martin Nervall; Hugo Gutierrez de teran; Elizabeth Hamelink; Linda K Janka; José C Clemente; Ben M Dunn; Adolf Gogoll; Bertil Samuelsson; Johan Qvist; Anders Hallberg
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV.
Bioorganic & medicinal chemistry 2006;14(7):2197-208.
2006: José C Clemente; Lakshmanan Govindasamy; Amrita Madabushi; S Zoë Fisher; Rebecca E Moose; Charles A Yowell; Koushi Hidaka; Tooru Kimura; Yoshio Hayashi; Yoshiaki Kiso; Mavis Agbandje-McKenna; John B Dame; Ben M Dunn; Robert McKenna
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 3):246-52.
2005: Nathan E Goldfarb; Minh T Lam; Arjo K Bose; Ambar M Patel; Alexander J Duckworth; Ben M Dunn
Electrostatic switches that mediate the pH-dependent conformational change of "short" recombinant human pseudocathepsin D.
Biochemistry 2005;44(48):15725-33.
2005: Karolina Ersmark; Martin Nervall; Elizabeth Hamelink; Linda K Janka; José C Clemente; Ben M Dunn; Michael J Blackman; Bertil Samuelsson; Johan Aqvist; Anders Hallberg
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.
Journal of medicinal chemistry 2005;48(19):6090-106.
2005: Hiroshi Oyama; Tomoko Fujisawa; Takao Suzuki; Ben M Dunn; Alexander Wlodawer; Kohei Oda
Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2).
Journal of biochemistry 2005;138(2):127-34.
2005: Steve Pettit; José C Clemente; Jennifer A Jeung; Ben M Dunn; Andrew H Kaplan
Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral protease.
Journal of virology 2005;79(16):10601-7.
2005: Pedro Castanheira; Bart Samyn; kjell sergeant; José C Clemente; Ben M Dunn; Euclides Pires; Jozef Van Beeumen; Carlos Faro
Activation, proteolytic processing, and peptide specificity of recombinant cardosin A.
The Journal of biological chemistry 2005;280(13):13047-54.
2005: Bret B Beyer; Jodie V Johnson; Alfred Y Chung; Tang Li; Amrita Madabushi; Mavis Agbandje-McKenna; Robert McKenna; John B Dame; Ben M Dunn
Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.
Biochemistry 2005;44(6):1768-79.
2005: Amrita Madabushi; Sibani Chakraborty; S Zoë Fisher; José C Clemente; Charles A Yowell; Mavis Agbandje-McKenna; John B Dame; Ben M Dunn; Robert McKenna
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):228-31.
2004: José C Clemente; Rebecca E Moose; Reena Hemrajani; Lisa R S Whitford; Lakshmanan Govindasamy; Robbie Reutzel; Robert McKenna; Mavis Agbandje-McKenna; Maureen M Goodenow; Ben M Dunn
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry 2004;43(38):12141-51.
2004: Bret B Beyer; Nathan E Goldfarb; Ben M Dunn
Expression, purification, and characterization of aspartic endopeptidases: Plasmodium plasmepsins and "short" recombinant human pseudocathepsin.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 21():Unit 21.14.
2004: Steve Pettit; Lori Everitt; Sumana Choudhury; Ben M Dunn; Andrew H Kaplan
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism.
Journal of virology 2004;78(16):8477-85.
2004: Tang Li; Charles A Yowell; Bret B Beyer; Su-Hwi Hung; Jennifer Westling; Minh T Lam; Ben M Dunn; John B Dame
Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man.
Molecular and biochemical parasitology 2004;135(1):101-9.
2004: Terry B Green; Omjoy Ganesh; Kyle Perry; Leif Smith; Lowri H Phylip; Timothy M Logan; Stephen J Hagen; Ben M Dunn; Arthur S Edison
IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution.
Biochemistry 2004;43(14):4071-81.
2004: Alexander Wlodawer; Mi Li; Alla Gustchina; Hiroshi Oyama; Kohei Oda; Bret B Beyer; Jose Clemente; Ben M Dunn
Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.
Biochemical and biophysical research communications 2004;314(2):638-45.
2003: José C Clemente; Reena Hemrajani; Lisa E Blum; Maureen M Goodenow; Ben M Dunn
Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.
Biochemistry 2003;42(51):15029-35.
2003: Alexander Wlodawer; Stewart R Durell; Mi Li; Hiroshi Oyama; Kohei Oda; Ben M Dunn
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases.
BMC structural biology 2003;3():8.
2003: Alexander Wlodawer; Mi Li; Alla Gustchina; Hiroshi Oyama; Ben M Dunn; Kohei Oda
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Acta biochimica Polonica 2003;50(1):81-102.
2002: Ben M Dunn
Structure and mechanism of the pepsin-like family of aspartic peptidases.
Chemical reviews 2002;102(12):4431-58.
2002: Hiroshi Oyama; Takatoshi Hamada; Shin Ogasawara; Kenichi Uchida; Sawao Murao; Bret B Beyer; Ben M Dunn; Kohei Oda
A CLN2-related and thermostable serine-carboxyl proteinase, kumamolysin: cloning, expression, and identification of catalytic serine residue.
Journal of biochemistry 2002;131(5):757-65.
2002: Maureen M Goodenow; Gregory Bloom; Stephanie L Rose; Steven M Pomeroy; Patricia O O'Brien; Elena E Perez; John W Sleasman; Ben M Dunn
Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
Virology 2002;292(1):137-49.
2002: Ben M Dunn
Anatomy and pathology of HIV-1 peptidase.
Essays in biochemistry 2002;38():113-27.
2002: Ben M Dunn; Maureen M Goodenow; Alla Gustchina; Alexander Wlodawer
Retroviral proteases.
Genome biology 2002;3(4):REVIEWS3006.
2001: Alexander Wlodawer; M Li; Alla Gustchina; Zbigniew Dauter; K Uchida; H Oyama; N E Goldfarb; Ben M Dunn; Kohei Oda
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase.
Biochemistry 2001;40(51):15602-11.
2001: Ben M Dunn
Overview of pepsin-like aspartic peptidases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 21():Unit 21.3.
2001: Alexander Wlodawer; Mi Li; Zbigniew Dauter; Alla Gustchina; K Uchida; Hiroshi Oyama; Ben M Dunn; Kohei Oda
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nature structural biology 2001;8(5):442-6.
2001: E E Perez; Stephanie L Rose; B Peyser; Susanna Lamers; Brant R Burkhardt; Ben M Dunn; A D Hutson; John W Sleasman; Maureen M Goodenow
Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients.
The Journal of infectious diseases 2001;183(4):579-88.
2001: Ben M Dunn
The 2-A postdoc.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1319-20.
2001: Lowri H Phylip; Wendy E Lees; B G Brownsey; Daniel Bur; Ben M Dunn; J R Winther; Alla Gustchina; Mi Li; T Copeland; Alexander Wlodawer; John Kay
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(3):2023-30.
2000: Kohei Oda; S Ogasawara; Hiroshi Oyama; Ben M Dunn
Subsite preferences of pepstatin-insensitive carboxyl proteinases from prokaryotes: kumamolysin, a thermostable pepstatin-insensitive carboxyl proteinase.
Journal of biochemistry 2000;128(3):499-507.
2000: Kenneth K-S Ng; JF Petersen; Maia M Cherney; Craig Garen; J J Zalatoris; C Rao-Naik; Ben M Dunn; M R Martzen; R J Peanasky; Michael N G James
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nature structural biology 2000;7(8):653-7.
2000: Ben M Dunn; S Hung
The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases.
Biochimica et biophysica acta 2000;1477(1-2):231-40.
2000: Mi Li; Lowri H Phylip; Wendy E Lees; J R Winther; Ben M Dunn; Alexander Wlodawer; John Kay; Alla Gustchina
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nature structural biology 2000;7(2):113-7.
1999: Jennifer Westling; P Cipullo; Su-Hwi Hung; H Saft; John B Dame; Ben M Dunn
Active site specificity of plasmepsin II.
Protein science : a publication of the Protein Society 1999;8(10):2001-9.
1999: Ben M Dunn; Michael Pennington; D C Frase; K Nash
Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem.
Biopolymers 1999;51(1):69-77.
1999: S Narutaki; Ben M Dunn; Kohei Oda
Subsite preferences of pepstatin-insensitive carboxyl proteinases from bacteria.
Journal of biochemistry 1999;125(1):75-81.
1998: Jukka Kervinen; Jacek Lubkowski; Alexander Zdanov; D Bhatt; Ben M Dunn; K Y Hui; David J Powell; John Kay; Alexander Wlodawer; Alla Gustchina
Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein science : a publication of the Protein Society 1998;7(11):2314-23.
1998: M Shibata; Ben M Dunn; Kohei Oda
Substrate specificity of pepstatin-insensitive carboxyl proteinase from Bacillus coagulans J-4.
Journal of biochemistry 1998;124(3):642-7.
1998: L Tyas; RP Moon; Hansruedi Loetscher; Ben M Dunn; John Kay; RG Ridley; Colin Berry
Plasmepsins I and II from the malarial parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1998;436():407-11.
1998: JF Petersen; MM Chernaia; C Rao-Naik; J L Zalatoris; Ben M Dunn; Michael N G James
X-ray crystallographic studies of the complex between porcine pepsin and the aspartic proteinase inhibitor PI-3 from the nematode Ascaris suum.
Advances in experimental medicine and biology 1998;436():391-5.
1998: J Zalatoris; C Rao-Naik; G Fecho; K Girdwood; J Kay; Ben M Dunn
Expression, purification, and characterization of the recombinant pepsin inhibitor from Ascaris suum.
Advances in experimental medicine and biology 1998;436():387-9.
1998: M Bukhtiyarova; C Rao-Naik; P J Tatnell; P C White; J Kay; Ben M Dunn
Detailed analysis of human cathepsin E prime region specificity.
Advances in experimental medicine and biology 1998;436():219-22.
1998: Ben M Dunn; Kohei Oda; J Kay; C Rao-Naik; W T Lowther; B M Beyer; P E Scarborough; M Bukhtiyarova
Comparison of the specificity of the aspartic proteinases towards internally consistent sets of oligopeptide substrates.
Advances in experimental medicine and biology 1998;436():133-8.
1998: S I Wilson; Lowri H Phylip; Sergei V Gulnik; J S Mills; Daniel Bur; Ben M Dunn; John Kay
Sensitivity to inhibition and catalytic efficiency of HIV proteinase mutants.
Advances in experimental medicine and biology 1998;436():85-9.
1998: G Bloom; E Perez; S Parikh; J Kay; J Mills; Maureen M Goodenow; Ben M Dunn
A comparison of gag-pol precursor cleavage in naturally arising HIV variants.
Advances in experimental medicine and biology 1998;436():53-7.
1998: David J Powell; Daniel Bur; Alexander Wlodawer; Alla Gustchina; Ben M Dunn; John Kay
The aspartic proteinase from equine infectious anaemia virus.
Advances in experimental medicine and biology 1998;436():41-5.
1998: B M Beyer; Ben M Dunn
Prime region subsite specificity characterization of human cathepsin D: the dominant role of position 128.
Protein science : a publication of the Protein Society 1998;7(1):88-95.
1997: Jennifer Westling; Charles A Yowell; P Majer; John W Erickson; John B Dame; Ben M Dunn
Plasmodium falciparum, P. vivax, and P. malariae: a comparison of the active site properties of plasmepsins cloned and expressed from three different species of the malaria parasite.
Experimental parasitology 1997;87(3):185-93.
1997: S I Wilson; Lowri H Phylip; J S Mills; Sergei V Gulnik; John W Erickson; Ben M Dunn; John Kay
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.
Biochimica et biophysica acta 1997;1339(1):113-25.
1997: RP Moon; L Tyas; U Certa; K Rupp; Daniel Bur; C Jacquet; Hugues Matile; Hansruedi Loetscher; F Grueninger-Leitch; John Kay; Ben M Dunn; Colin Berry; RG Ridley
Expression and characterisation of plasmepsin I from Plasmodium falciparum.
European journal of biochemistry / FEBS 1997;244(2):552-60.
1996: David J Powell; Daniel Bur; Alexander Wlodawer; Alla Gustchina; S L Payne; Ben M Dunn; J Kay
Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.
European journal of biochemistry / FEBS 1996;241(2):664-74.
1996: M Ito; Ben M Dunn; Kohei Oda
Substrate specificities of pepstatin-insensitive carboxyl proteinases from gram-negative bacteria.
Journal of biochemistry 1996;120(4):845-50.
1996: B M Beyer; Ben M Dunn
Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, "short" pseudocathepsin D.
The Journal of biological chemistry 1996;271(26):15590-6.
1996: K A Barrie; E E Perez; Susanna Lamers; William G Farmerie; Ben M Dunn; John W Sleasman; Maureen M Goodenow
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.
Virology 1996;219(2):407-16.
1996: J Kay; L Tyas; M J Humphreys; jeffrey hill; Ben M Dunn; Colin Berry
Aspartic proteinases from parasites.
Advances in experimental medicine and biology 1996;389():247-50.
1995: S D Fowler; J Kay; Ben M Dunn; P J Tatnell
Monomeric human cathepsin E.
FEBS letters 1995;366(1):72-4.
1995: C Rao-Naik; K Guruprasad; BL Batley; Stephen T Rapundalo; J Hill; jeffrey hill; J Kay; Ben M Dunn
Exploring the binding preferences/specificity in the active site of human cathepsin E.
Proteins 1995;22(2):168-81.
1995: W T Lowther; P Majer; Ben M Dunn
Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1.
Protein science : a publication of the Protein Society 1995;4(4):689-702.
1995: C Rao; Ben M Dunn
Evidence for electrostatic interactions in the S2 subsite of porcine pepsin.
Advances in experimental medicine and biology 1995;362():91-4.
1995: N Tarasova; N D Denslow; B F Parten; N Tran; H P Nhuyen; A Jones; N B Roberts; Ben M Dunn
A comparative study on amino acid sequences of three major isoforms of human pepsin A.
Advances in experimental medicine and biology 1995;362():77-81.
1995: W T Lowther; Ben M Dunn
Site-directed mutagenesis of rhizopuspepsin: an analysis of unique specificity.
Advances in experimental medicine and biology 1995;362():555-8.
1995: Colin Berry; J B Dame; Ben M Dunn; J Kay
Aspartic proteinases from the human malaria parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1995;362():511-8.
1995: Lowri H Phylip; J T Griffiths; J S Mills; M C Graves; Ben M Dunn; J Kay
Activities of precursor and tethered dimer forms of HIV proteinase.
Advances in experimental medicine and biology 1995;362():467-72.
1995: B M Beyer; Ben M Dunn
Site-directed mutagenesis of a disulfide bridge in cathepsin D: expression, activation, purification, and characterization.
Advances in experimental medicine and biology 1995;362():285-7.
1995: Ben M Dunn; P E Scarborough; W T Lowther; C Rao-Naik
Comparison of the active site specificity of the aspartic proteinases based on a systematic series of peptide substrates.
Advances in experimental medicine and biology 1995;362():1-9.
1994: P J Johansson; CC Malone; W Swietnicki; Ben M Dunn; RC Williams
Fv structure of monoclonal antibody II-481 against herpes simplex virus Fc gamma-binding glycoprotein gE contains immunodominant complementarity determining region epitopes that react with human immunoglobulin M rheumatoid factors.
The Journal of experimental medicine 1994;180(5):1873-88.
1994: jeffrey hill; L Tyas; Lowri H Phylip; J Kay; Ben M Dunn; Colin Berry
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum.
FEBS letters 1994;352(2):155-8.
1994: Colin Berry; J B Dame; Ben M Dunn; J Kay
Aspartic proteinases from the human malarial parasite Plasmodium falciparum.
Biochemical Society transactions 1994;22(3):305S.
1994: John B Dame; GR Reddy; Charles A Yowell; Ben M Dunn; J Kay; C Berry
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum.
Molecular and biochemical parasitology 1994;64(2):177-90.
1994: P E Scarborough; Ben M Dunn
Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite.
Protein engineering 1994;7(4):495-502.
1994: J T Griffiths; L A Tomchak; J S Mills; M C Graves; N D Cook; Ben M Dunn; J Kay
Interactions of substrates and inhibitors with a family of tethered HIV-1 and HIV-2 homo- and heterodimeric proteinases.
The Journal of biological chemistry 1994;269(7):4787-93.
1994: Ben M Dunn; A Gustchina; A Wlodawer; J Kay
Subsite preferences of retroviral proteinases.
Methods in enzymology 1994;241():254-78.
1994: Ben M Dunn; P E Scarborough; R Davenport; W Swietnicki
Analysis of proteinase specificity by studies of peptide substrates. The use of UV and fluorescence spectroscopy to quantitate rates of enzymatic cleavage.
Methods in molecular biology (Clifton, N.J.) 1994;36():225-43.
1993: C M Rao; P E Scarborough; J Kay; BL Batley; Stephen T Rapundalo; Sylvester R Klutchko; M D Taylor; Elizabeth A Lunney; Christine Humblet; Ben M Dunn
Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.
Journal of medicinal chemistry 1993;36(18):2614-20.
1993: P E Scarborough; K Guruprasad; C Topham; G R Richo; Gregory Conner; Tom L Blundell; Ben M Dunn
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.
Protein science : a publication of the Protein Society 1993;2(2):264-76.
1992: Lowri H Phylip; J S Mills; B F Parten; Ben M Dunn; J Kay
Intrinsic activity of precursor forms of HIV-1 proteinase.
FEBS letters 1992;314(3):449-54.
1992: J Cooper; W Quail; C Frazao; SI Foundling; Tom L Blundell; Christine Humblet; Elizabeth A Lunney; W T Lowther; Ben M Dunn
X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.
Biochemistry 1992;31(35):8142-50.
1992: David Jewell; W Swietnicki; Ben M Dunn; B A Malcolm
Hepatitis A virus 3C proteinase substrate specificity.
Biochemistry 1992;31(34):7862-9.
1992: J T Griffiths; Lowri H Phylip; Jan Konvalinka; P Strop; A Gustchina; A Wlodawer; R J Davenport; R Briggs; Ben M Dunn; J Kay
Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites.
Biochemistry 1992;31(22):5193-200.
1992: A D Richards; J Kay; Ben M Dunn; C M Bessant; P A Charlton
Inhibition of aspartic proteinases by synthetic peptides derived from the propart region of human prorenin.
The International journal of biochemistry 1992;24(2):297-301.
1992: J Kay; Ben M Dunn
Substrate specificity and inhibitors of aspartic proteinases.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1992;210():23-30.
1991: R A Jupp; A D Richards; Lowri H Phylip; J Kay; Jan Konvalinka; P Strop; V Kostka; P E Scarborough; William G Farmerie; Ben M Dunn
Substrate cleavage by HIV-1 proteinase.
Advances in experimental medicine and biology 1991;306():461-7.
1991: P E Scarborough; G R Richo; J Kay; Gregory Conner; Ben M Dunn
Comparison of kinetic properties of native and recombinant human cathepsin D.
Advances in experimental medicine and biology 1991;306():343-7.
1991: W T Lowther; Z Chen; Xinli Lin; Jordan Tang; Ben M Dunn
Substrate specificity study of recombinant Rhizopus chinensis aspartic proteinase.
Advances in experimental medicine and biology 1991;306():275-9.
1991: C Rao; P E Scarborough; W T Lowther; J Kay; BL Batley; Stephen T Rapundalo; Sylvester R Klutchko; M D Taylor; Ben M Dunn
Structure-function database for active site binding to the aspartic proteinases.
Advances in experimental medicine and biology 1991;306():143-7.
1991: William G Farmerie; Maureen M Goodenow; Ben M Dunn
Cloning, expression and kinetic characterization of the feline immunodeficiency virus proteinase.
Advances in experimental medicine and biology 1991;306():511-3.
1990: Michael Pennington; William R Kem; Raymond S Norton; Ben M Dunn
Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus.
International journal of peptide and protein research 1990;36(4):335-43.
1990: Michael Pennington; William R Kem; Ben M Dunn
Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin.
Peptide research 1990;3(5):228-32.
1990: Jan Konvalinka; P Strop; J Velek; V Cerna; V Kostka; Lowri H Phylip; A D Richards; Ben M Dunn; J Kay
Sub-site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1.
FEBS letters 1990;268(1):35-8.
1990: A D Richards; Lowri H Phylip; William G Farmerie; P E Scarborough; A Alvarez; Ben M Dunn; P H Hirel; Jan Konvalinka; P Strop; L Pavlickova
Sensitive, soluble chromogenic substrates for HIV-1 proteinase.
The Journal of biological chemistry 1990;265(14):7733-6.
1990: R A Jupp; Ben M Dunn; J W Jacobs; G Vlasuk; K E Arcuri; D F Veber; Debra S Perlow; L S Payne; J Boger; Stephen E de Laszlo
The selectivity of statine-based inhibitors against various human aspartic proteinases.
The Biochemical journal 1990;265(3):871-8.
1990: J Kay; Ben M Dunn
Viral proteinases: weakness in strength.
Biochimica et biophysica acta 1990;1048(1):1-18.
1989: A D Richards; A V Broadhurst; A J Ritchie; Ben M Dunn; J Kay
Inhibition of the aspartic proteinase from HIV-2.
FEBS letters 1989;253(1-2):214-6.
1989: William R Kem; B Parten; Michael Pennington; D A Price; Ben M Dunn
Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus.
Biochemistry 1989;28(8):3483-9.
1989: A D Richards; R Roberts; Ben M Dunn; M C Graves; J Kay
Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.
FEBS letters 1989;247(1):113-7.
1989: D J Thomas; A D Richards; R A Jupp; E Ueno; K Yamamoto; I M Samloff; Ben M Dunn; J Kay
Stabilisation of cathepsin E by ATP.
FEBS letters 1989;243(2):145-8.
1988: R A Jupp; A D Richards; J Kay; Ben M Dunn; Jeffrey Bruce Wyckoff; I M Samloff; K Yamamoto
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.
The Biochemical journal 1988;254(3):895-8.
1988: J Pohl; Ben M Dunn
Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site.
Biochemistry 1988;27(13):4827-34.
1988: J Kay; R A Jupp; C G Norey; A D Richards; W A Reid; R T Taggart; I M Samloff; Ben M Dunn
Aspartic proteinases and inhibitors for their control in health and disease.
Advances in experimental medicine and biology 1988;240():1-11.
1988: William R Kem; Ben M Dunn
Separation and characterization of four different amino acid sequence variants of a sea anemone (Stichodactyla helianthus) protein cytolysin.
Toxicon : official journal of the International Society on Toxinology 1988;26(11):997-1008.
1987: Ben M Dunn; M J Valler; C E Rolph; SI Foundling; M Jimenez; J Kay
The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2.
Biochimica et biophysica acta 1987;913(2):122-30.
1986: Ben M Dunn; M Jimenez; B F Parten; M J Valler; C E Rolph; J Kay
A systematic series of synthetic chromophoric substrates for aspartic proteinases.
The Biochemical journal 1986;237(3):899-906.
1985: T Dreyer; M J Valler; J Kay; P Charlton; Ben M Dunn
The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).
The Biochemical journal 1985;231(3):777-9.
1985: M J Valler; J Kay; T Aoyagi; Ben M Dunn
The interaction of aspartic proteinases with naturally-occurring inhibitors from actinomycetes and Ascaris lumbricoides.
Journal of enzyme inhibition 1985;1(1):77-82.