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Ben Dunn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Procedures

X-Ray Crystallography

Living Beings

HIV-1

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Co-Publications
Name
14
Goodenow, Maureen
13
Clemente, José
13
Wlodawer, Alexander
12
Phylip, Lowri
11
Gustchina, Alla
11
McKenna, Robert
11
Oda, Kohei
9
Dame, John
8
Agbandje-McKenna, Mavis
8
Oyama, Hiroshi
8
Kay, John
7
Li, Mi
7
Rao-Naik, C
7
Yowell, Charles
6
Berry, Colin

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Publications

TOP 3
Kear Jamie L; Blackburn Mandy E; Veloro Angelo M; Dunn Ben M; Fanucci Gail E
Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility.
Dunn Ben M; Uversky Vladimir N
Cryoenzymology: enzyme action in slow motion.
Orrling Kristina M; Marzahn Melissa R; Gutiérrez-de-Terán Hugo; Aqvist Johan; Dunn Ben M; Larhed Mats
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.

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All Publications

2009: Kear Jamie L; Blackburn Mandy E; Veloro Angelo M; Dunn Ben M; Fanucci Gail E
Subtype polymorphisms among HIV-1 protease variants confer altered flap conformations and flexibility.
Journal of the American Chemical Society 2009;131(41):14650-1.
2009: Dunn Ben M; Uversky Vladimir N
Cryoenzymology: enzyme action in slow motion.
Current protein & peptide science 2009;10(5):408-15.
2009: Orrling Kristina M; Marzahn Melissa R; Gutiérrez-de-Terán Hugo; Aqvist Johan; Dunn Ben M; Larhed Mats
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
Bioorganic & medicinal chemistry 2009;17(16):5933-49.
2009: Ho Sarah K; Perez Elena E; Rose Stephanie L; Coman Roxana M; Lowe Amanda C; Hou Wei; Ma Changxing; Lawrence Robert M; Dunn Ben M; Sleasman John W; Goodenow Maureen M
Genetic determinants in HIV-1 Gag and Env V3 are related to viral response to combination antiretroviral therapy with a protease inhibitor.
AIDS (London, England) 2009;23(13):1631-40.
2009: Liu Peng; Marzahn Melissa R; Robbins Arthur H; Gutiérrez-de-Terán Hugo; Rodríguez David; McClung Scott H; Stevens Stanley M; Yowell Charles A; Dame John B; McKenna Robert; Dunn Ben M
Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
Biochemistry 2009;48(19):4086-99.
2009: Robbins Arthur H; Dunn Ben M; Agbandje-McKenna Mavis; McKenna Robert
Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 3):294-6.
2008: Ho Sarah K; Coman Roxana M; Bunger Joshua C; Rose Stephanie L; O'Brien Patricia; Munoz Isabel; Dunn Ben M; Sleasman John W; Goodenow Maureen M
Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response.
Virology 2008;378(2):272-81.
2008: Coman Roxana M; Robbins Arthur H; Goodenow Maureen M; Dunn Ben M; McKenna Robert
High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):754-63.
2008: Clemente José C; Robbins Arthur; Graña Paula; Paleo M Rita; Correa Juan F; Villaverde M Carmen; Sardina F Javier; Govindasamy Lakshmanan; Agbandje-McKenna Mavis; McKenna Robert; Dunn Ben M; Sussman Fredy
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
Journal of medicinal chemistry 2008;51(4):852-60.
2008: Coman Roxana M; Robbins Arthur H; Fernandez Marty A; Gilliland C Taylor; Sochet Anthony A; Goodenow Maureen M; McKenna Robert; Dunn Ben M
The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.
Biochemistry 2008;47(2):731-43.
2008: Janka Linda; Clemente Jose; Vaiana N; Sparatore A; Romeo Sergio; Dunn Ben M
Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors.
Protein and peptide letters 2008;15(9):868-73.
2008: Dunn Ben M
Protein and peptide letters.
Protein and peptide letters 2008;15(9):866-7.
2008: Dunn Ben M
Editorial. BACE or beta-secretase -a target for drug discovery for treatment of Alzheimer's disease.
Protein and peptide letters 2008;15(2):118.
2007: Moose Rebecca E; Clemente José C; Jackson Larry R; Ngo Minh; Wooten Kimberly; Chang Richard; Bennett Antonette; Chakraborty Sibani; Yowell Charles A; Dame John B; Agbandje-McKenna Mavis; Dunn Ben M
Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.
Biochemistry 2007;46(49):14198-205.
2007: Coman Roxana M; Robbins Arthur; Goodenow Maureen M; McKenna Robert; Dunn Ben M
Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 4):320-3.
2006: Gutiérrez-de-Terán Hugo; Nervall Martin; Dunn Ben M; Clemente Jose C; Aqvist Johan
Computational analysis of plasmepsin IV bound to an allophenylnorstatine inhibitor.
FEBS letters 2006;580(25):5910-6.
2006: Okubo Ayumi; Li Mi; Ashida Masako; Oyama Hiroshi; Gustchina Alla; Oda Kohei; Dunn Ben M; Wlodawer Alexander; Nakayama Toru
Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
The FEBS journal 2006;273(11):2563-76.
2006: Clemente José C; Coman Roxana M; Thiaville Michele M; Janka Linda K; Jeung Jennifer A; Nukoolkarn Sarawut; Govindasamy Lakshmanan; Agbandje-McKenna Mavis; McKenna Robert; Leelamanit Wichet; Goodenow Maureen M; Dunn Ben M
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry 2006;45(17):5468-77.
2006: Ersmark Karolina; Nervall Martin; Gutiérrez-de-Terán Hugo; Hamelink Elizabeth; Janka Linda K; Clemente Jose C; Dunn Ben M; Gogoll Adolf; Samuelsson Bertil; Qvist Johan; Hallberg Anders
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV.
Bioorganic & medicinal chemistry 2006;14(7):2197-208.
2006: Clemente José C; Govindasamy Lakshmanan; Madabushi Amrita; Fisher S Zoë; Moose Rebecca E; Yowell Charles A; Hidaka Koushi; Kimura Tooru; Hayashi Yoshio; Kiso Yoshiaki; Agbandje-McKenna Mavis; Dame John B; Dunn Ben M; McKenna Robert
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 3):246-52.
2005: Goldfarb Nathan E; Lam Minh T; Bose Arjo K; Patel Ambar M; Duckworth Alexander J; Dunn Ben M
Electrostatic switches that mediate the pH-dependent conformational change of "short" recombinant human pseudocathepsin D.
Biochemistry 2005;44(48):15725-33.
2005: Ersmark Karolina; Nervall Martin; Hamelink Elizabeth; Janka Linda K; Clemente Jose C; Dunn Ben M; Blackman Michael J; Samuelsson Bertil; Aqvist Johan; Hallberg Anders
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.
Journal of medicinal chemistry 2005;48(19):6090-106.
2005: Oyama Hiroshi; Fujisawa Tomoko; Suzuki Takao; Dunn Ben M; Wlodawer Alexander; Oda Kohei
Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2).
Journal of biochemistry 2005;138(2):127-34.
2005: Pettit Steven C; Clemente Jose C; Jeung Jennifer A; Dunn Ben M; Kaplan Andrew H
Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral protease.
Journal of virology 2005;79(16):10601-7.
2005: Castanheira Pedro; Samyn Bart; Sergeant Kjell; Clemente José C; Dunn Ben M; Pires Euclides; Van Beeumen Jozef; Faro Carlos
Activation, proteolytic processing, and peptide specificity of recombinant cardosin A.
The Journal of biological chemistry 2005;280(13):13047-54.
2005: Madabushi Amrita; Chakraborty Sibani; Fisher S Zoë; Clemente José C; Yowell Charles; Agbandje-McKenna Mavis; Dame John B; Dunn Ben M; McKenna Robert
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):228-31.
2005: Beyer Bret B; Johnson Jodie V; Chung Alfred Y; Li Tang; Madabushi Amrita; Agbandje-McKenna Mavis; McKenna Robert; Dame John B; Dunn Ben M
Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.
Biochemistry 2005;44(6):1768-79.
2004: Clemente José C; Moose Rebecca E; Hemrajani Reena; Whitford Lisa R S; Govindasamy Lakshmanan; Reutzel Robbie; McKenna Robert; Agbandje-McKenna Mavis; Goodenow Maureen M; Dunn Ben M
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry 2004;43(38):12141-51.
2004: Beyer Bret B; Goldfarb Nathan E; Dunn Ben M
Expression, purification, and characterization of aspartic endopeptidases: Plasmodium plasmepsins and "short" recombinant human pseudocathepsin.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 21():Unit 21.14.
2004: Pettit Steven C; Everitt Lorraine E; Choudhury Sumana; Dunn Ben M; Kaplan Andrew H
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism.
Journal of virology 2004;78(16):8477-85.
2004: Li Tang; Yowell Charles A; Beyer Bret B; Hung Su-Hwi; Westling Jennifer; Lam Minh T; Dunn Ben M; Dame John B
Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man.
Molecular and biochemical parasitology 2004;135(1):101-9.
2004: Green Terry B; Ganesh Omjoy; Perry Kyle; Smith Leif; Phylip Lowri H; Logan Timothy M; Hagen Stephen J; Dunn Ben M; Edison Arthur S
IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution.
Biochemistry 2004;43(14):4071-81.
2004: Wlodawer Alexander; Li Mi; Gustchina Alla; Oyama Hiroshi; Oda Kohei; Beyer Bret B; Clemente Jose; Dunn Ben M
Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.
Biochemical and biophysical research communications 2004;314(2):638-45.
2003: Clemente José C; Hemrajani Reena; Blum Lisa E; Goodenow Maureen M; Dunn Ben M
Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.
Biochemistry 2003;42(51):15029-35.
2003: Wlodawer Alexander; Durell Stewart R; Li Mi; Oyama Hiroshi; Oda Kohei; Dunn Ben M
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases.
BMC structural biology 2003;3():8.
2003: Wlodawer Alexander; Li Mi; Gustchina Alla; Oyama Hiroshi; Dunn Ben M; Oda Kohei
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Acta biochimica Polonica 2003;50(1):81-102.
2002: Dunn Ben M
Structure and mechanism of the pepsin-like family of aspartic peptidases.
Chemical reviews 2002;102(12):4431-58.
2002: Oyama Hiroshi; Hamada Takatoshi; Ogasawara Shin; Uchida Kenichi; Murao Sawao; Beyer Bret B; Dunn Ben M; Oda Kohei
A CLN2-related and thermostable serine-carboxyl proteinase, kumamolysin: cloning, expression, and identification of catalytic serine residue.
Journal of biochemistry 2002;131(5):757-65.
2002: Goodenow Maureen M; Bloom Gregory; Rose Stephanie L; Pomeroy Steven M; O'Brien Patricia O; Perez Elena E; Sleasman John W; Dunn Ben M
Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
Virology 2002;292(1):137-49.
2002: Dunn Ben M
Anatomy and pathology of HIV-1 peptidase.
Essays in biochemistry 2002;38():113-27.
2002: Dunn Ben M; Goodenow Maureen M; Gustchina Alla; Wlodawer Alexander
Retroviral proteases.
Genome biology 2002;3(4):REVIEWS3006.
2001: Wlodawer A; Li M; Gustchina A; Dauter Z; Uchida K; Oyama H; Goldfarb N E; Dunn B M; Oda K
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase.
Biochemistry 2001;40(51):15602-11.
2001: Dunn B M
Overview of pepsin-like aspartic peptidases.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2001;Chapter 21():Unit 21.3.
2001: Wlodawer A; Li M; Dauter Z; Gustchina A; Uchida K; Oyama H; Dunn B M; Oda K
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nature structural biology 2001;8(5):442-6.
2001: Dunn B M
The 2-A postdoc.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1319-20.
2001: Perez E E; Rose S L; Peyser B; Lamers S L; Burkhardt B; Dunn B M; Hutson A D; Sleasman J W; Goodenow M M
Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients.
The Journal of infectious diseases 2001;183(4):579-88.
2001: Phylip L H; Lees W E; Brownsey B G; Bur D; Dunn B M; Winther J R; Gustchina A; Li M; Copeland T; Wlodawer A; Kay J
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(3):2023-30.
2000: Oda K; Ogasawara S; Oyama H; Dunn B M
Subsite preferences of pepstatin-insensitive carboxyl proteinases from prokaryotes: kumamolysin, a thermostable pepstatin-insensitive carboxyl proteinase.
Journal of biochemistry 2000;128(3):499-507.
2000: Ng K K; Petersen J F; Cherney M M; Garen C; Zalatoris J J; Rao-Naik C; Dunn B M; Martzen M R; Peanasky R J; James M N
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nature structural biology 2000;7(8):653-7.
2000: Dunn B M; Hung S
The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases.
Biochimica et biophysica acta 2000;1477(1-2):231-40.
2000: Li M; Phylip L H; Lees W E; Winther J R; Dunn B M; Wlodawer A; Kay J; Gustchina A
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nature structural biology 2000;7(2):113-7.
1999: Westling J; Cipullo P; Hung S H; Saft H; Dame J B; Dunn B M
Active site specificity of plasmepsin II.
Protein science : a publication of the Protein Society 1999;8(10):2001-9.
1999: Narutaki S; Dunn B M; Oda K
Subsite preferences of pepstatin-insensitive carboxyl proteinases from bacteria.
Journal of biochemistry 1999;125(1):75-81.
1999: Dunn B M; Pennington M W; Frase D C; Nash K
Comparison of inhibitor binding to feline and human immunodeficiency virus proteases: structure-based drug design and the resistance problem.
Biopolymers 1999;51(1):69-77.
1998: Kervinen J; Lubkowski J; Zdanov A; Bhatt D; Dunn B M; Hui K Y; Powell D J; Kay J; Wlodawer A; Gustchina A
Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein science : a publication of the Protein Society 1998;7(11):2314-23.
1998: Shibata M; Dunn B M; Oda K
Substrate specificity of pepstatin-insensitive carboxyl proteinase from Bacillus coagulans J-4.
Journal of biochemistry 1998;124(3):642-7.
1998: Beyer B M; Dunn B M
Prime region subsite specificity characterization of human cathepsin D: the dominant role of position 128.
Protein science : a publication of the Protein Society 1998;7(1):88-95.
1998: Tyas L; Moon R P; Loetscher H; Dunn B M; Kay J; Ridley R G; Berry C
Plasmepsins I and II from the malarial parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1998;436():407-11.
1998: Petersen J F; Chernaia M M; Rao-Naik C; Zalatoris J L; Dunn B M; James M N
X-ray crystallographic studies of the complex between porcine pepsin and the aspartic proteinase inhibitor PI-3 from the nematode Ascaris suum.
Advances in experimental medicine and biology 1998;436():391-5.
1998: Zalatoris J; Rao-Naik C; Fecho G; Girdwood K; Kay J; Dunn B M
Expression, purification, and characterization of the recombinant pepsin inhibitor from Ascaris suum.
Advances in experimental medicine and biology 1998;436():387-9.
1998: Bukhtiyarova M; Rao-Naik C; Tatnell P J; White P C; Kay J; Dunn B M
Detailed analysis of human cathepsin E prime region specificity.
Advances in experimental medicine and biology 1998;436():219-22.
1998: Dunn B M; Oda K; Kay J; Rao-Naik C; Lowther W T; Beyer B M; Scarborough P E; Bukhtiyarova M
Comparison of the specificity of the aspartic proteinases towards internally consistent sets of oligopeptide substrates.
Advances in experimental medicine and biology 1998;436():133-8.
1998: Wilson S I; Phylip L H; Gulnik S V; Mills J S; Bur D; Dunn B M; Kay J
Sensitivity to inhibition and catalytic efficiency of HIV proteinase mutants.
Advances in experimental medicine and biology 1998;436():85-9.
1998: Bloom G; Perez E; Parikh S; Kay J; Mills J; Goodenow M; Dunn B M
A comparison of gag-pol precursor cleavage in naturally arising HIV variants.
Advances in experimental medicine and biology 1998;436():53-7.
1998: Powell D J; Bur D; Wlodawer A; Gustchina A; Dunn B M; Kay J
The aspartic proteinase from equine infectious anaemia virus.
Advances in experimental medicine and biology 1998;436():41-5.
1997: Westling J; Yowell C A; Majer P; Erickson J W; Dame J B; Dunn B M
Plasmodium falciparum, P. vivax, and P. malariae: a comparison of the active site properties of plasmepsins cloned and expressed from three different species of the malaria parasite.
Experimental parasitology 1997;87(3):185-93.
1997: Wilson S I; Phylip L H; Mills J S; Gulnik S V; Erickson J W; Dunn B M; Kay J
Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.
Biochimica et biophysica acta 1997;1339(1):113-25.
1997: Moon R P; Tyas L; Certa U; Rupp K; Bur D; Jacquet C; Matile H; Loetscher H; Grueninger-Leitch F; Kay J; Dunn B M; Berry C; Ridley R G
Expression and characterisation of plasmepsin I from Plasmodium falciparum.
European journal of biochemistry / FEBS 1997;244(2):552-60.
1996: Ito M; Dunn B M; Oda K
Substrate specificities of pepstatin-insensitive carboxyl proteinases from gram-negative bacteria.
Journal of biochemistry 1996;120(4):845-50.
1996: Powell D J; Bur D; Wlodawer A; Gustchina A; Payne S L; Dunn B M; Kay J
Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.
European journal of biochemistry / FEBS 1996;241(2):664-74.
1996: Beyer B M; Dunn B M
Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, "short" pseudocathepsin D.
The Journal of biological chemistry 1996;271(26):15590-6.
1996: Barrie K A; Perez E E; Lamers S L; Farmerie W G; Dunn B M; Sleasman J W; Goodenow M M
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.
Virology 1996;219(2):407-16.
1996: Kay J; Tyas L; Humphreys M J; Hill J; Dunn B M; Berry C
Aspartic proteinases from parasites.
Advances in experimental medicine and biology 1996;389():247-50.
1995: Fowler S D; Kay J; Dunn B M; Tatnell P J
Monomeric human cathepsin E.
FEBS letters 1995;366(1):72-4.
1995: Rao-Naik C; Guruprasad K; Batley B; Rapundalo S; Hill J; Blundell T; Kay J; Dunn B M
Exploring the binding preferences/specificity in the active site of human cathepsin E.
Proteins 1995;22(2):168-81.
1995: Lowther W T; Majer P; Dunn B M
Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1.
Protein science : a publication of the Protein Society 1995;4(4):689-702.
1995: Rao C; Dunn B M
Evidence for electrostatic interactions in the S2 subsite of porcine pepsin.
Advances in experimental medicine and biology 1995;362():91-4.
1995: Tarasova N; Denslow N D; Parten B F; Tran N; Nhuyen H P; Jones A; Roberts N B; Dunn B M
A comparative study on amino acid sequences of three major isoforms of human pepsin A.
Advances in experimental medicine and biology 1995;362():77-81.
1995: Lowther W T; Dunn B M
Site-directed mutagenesis of rhizopuspepsin: an analysis of unique specificity.
Advances in experimental medicine and biology 1995;362():555-8.
1995: Berry C; Dame J B; Dunn B M; Kay J
Aspartic proteinases from the human malaria parasite Plasmodium falciparum.
Advances in experimental medicine and biology 1995;362():511-8.
1995: Phylip L H; Griffiths J T; Mills J S; Graves M C; Dunn B M; Kay J
Activities of precursor and tethered dimer forms of HIV proteinase.
Advances in experimental medicine and biology 1995;362():467-72.
1995: Beyer B M; Dunn B M
Site-directed mutagenesis of a disulfide bridge in cathepsin D: expression, activation, purification, and characterization.
Advances in experimental medicine and biology 1995;362():285-7.
1995: Dunn B M; Scarborough P E; Lowther W T; Rao-Naik C
Comparison of the active site specificity of the aspartic proteinases based on a systematic series of peptide substrates.
Advances in experimental medicine and biology 1995;362():1-9.
1994: Johansson P J; Malone C; Swietnicki W; Dunn B M; Williams R C
Fv structure of monoclonal antibody II-481 against herpes simplex virus Fc gamma-binding glycoprotein gE contains immunodominant complementarity determining region epitopes that react with human immunoglobulin M rheumatoid factors.
The Journal of experimental medicine 1994;180(5):1873-88.
1994: Hill J; Tyas L; Phylip L H; Kay J; Dunn B M; Berry C
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum.
FEBS letters 1994;352(2):155-8.
1994: Berry C; Dame J B; Dunn B M; Kay J
Aspartic proteinases from the human malarial parasite Plasmodium falciparum.
Biochemical Society transactions 1994;22(3):305S.
1994: Dame J B; Reddy G R; Yowell C A; Dunn B M; Kay J; Berry C
Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum.
Molecular and biochemical parasitology 1994;64(2):177-90.
1994: Scarborough P E; Dunn B M
Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite.
Protein engineering 1994;7(4):495-502.
1994: Griffiths J T; Tomchak L A; Mills J S; Graves M C; Cook N D; Dunn B M; Kay J
Interactions of substrates and inhibitors with a family of tethered HIV-1 and HIV-2 homo- and heterodimeric proteinases.
The Journal of biological chemistry 1994;269(7):4787-93.
1994: Dunn B M; Gustchina A; Wlodawer A; Kay J
Subsite preferences of retroviral proteinases.
Methods in enzymology 1994;241():254-78.
1994: Dunn B M; Scarborough P E; Davenport R; Swietnicki W
Analysis of proteinase specificity by studies of peptide substrates. The use of UV and fluorescence spectroscopy to quantitate rates of enzymatic cleavage.
Methods in molecular biology (Clifton, N.J.) 1994;36():225-43.
1993: Rao C M; Scarborough P E; Kay J; Batley B; Rapundalo S; Klutchko S; Taylor M D; Lunney E A; Humblet C C; Dunn B M
Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.
Journal of medicinal chemistry 1993;36(18):2614-20.
1993: Scarborough P E; Guruprasad K; Topham C; Richo G R; Conner G E; Blundell T L; Dunn B M
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.
Protein science : a publication of the Protein Society 1993;2(2):264-76.
1992: Phylip L H; Mills J S; Parten B F; Dunn B M; Kay J
Intrinsic activity of precursor forms of HIV-1 proteinase.
FEBS letters 1992;314(3):449-54.
1992: Cooper J; Quail W; Frazao C; Foundling S I; Blundell T L; Humblet C; Lunney E A; Lowther W T; Dunn B M
X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.
Biochemistry 1992;31(35):8142-50.
1992: Jewell D A; Swietnicki W; Dunn B M; Malcolm B A
Hepatitis A virus 3C proteinase substrate specificity.
Biochemistry 1992;31(34):7862-9.
1992: Griffiths J T; Phylip L H; Konvalinka J; Strop P; Gustchina A; Wlodawer A; Davenport R J; Briggs R; Dunn B M; Kay J
Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites.
Biochemistry 1992;31(22):5193-200.
1992: Richards A D; Kay J; Dunn B M; Bessant C M; Charlton P A
Inhibition of aspartic proteinases by synthetic peptides derived from the propart region of human prorenin.
The International journal of biochemistry 1992;24(2):297-301.
1992: Kay J; Dunn B M
Substrate specificity and inhibitors of aspartic proteinases.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1992;210():23-30.
1991: Jupp R A; Richards A D; Phylip L H; Kay J; Konvalinka J; Strop P; Kostka V; Scarborough P E; Farmerie W G; Dunn B M
Substrate cleavage by HIV-1 proteinase.
Advances in experimental medicine and biology 1991;306():461-7.
1991: Scarborough P E; Richo G R; Kay J; Conner G E; Dunn B M
Comparison of kinetic properties of native and recombinant human cathepsin D.
Advances in experimental medicine and biology 1991;306():343-7.
1991: Lowther W T; Chen Z; Lin X L; Tang J; Dunn B M
Substrate specificity study of recombinant Rhizopus chinensis aspartic proteinase.
Advances in experimental medicine and biology 1991;306():275-9.
1991: Rao C; Scarborough P E; Lowther W T; Kay J; Batley B; Rapundalo S; Klutchko S; Taylor M D; Dunn B M
Structure-function database for active site binding to the aspartic proteinases.
Advances in experimental medicine and biology 1991;306():143-7.
1991: Farmerie W G; Goodenow M M; Dunn B M
Cloning, expression and kinetic characterization of the feline immunodeficiency virus proteinase.
Advances in experimental medicine and biology 1991;306():511-3.
1990: Pennington M W; Kem W R; Norton R S; Dunn B M
Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus.
International journal of peptide and protein research 1990;36(4):335-43.
1990: Pennington M W; Kem W R; Dunn B M
Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin.
Peptide research 1990;3(5):228-32.
1990: Konvalinka J; Strop P; Velek J; Cerna V; Kostka V; Phylip L H; Richards A D; Dunn B M; Kay J
Sub-site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1.
FEBS letters 1990;268(1):35-8.
1990: Richards A D; Phylip L H; Farmerie W G; Scarborough P E; Alvarez A; Dunn B M; Hirel P H; Konvalinka J; Strop P; Pavlickova L
Sensitive, soluble chromogenic substrates for HIV-1 proteinase.
The Journal of biological chemistry 1990;265(14):7733-6.
1990: Jupp R A; Dunn B M; Jacobs J W; Vlasuk G; Arcuri K E; Veber D F; Perlow D S; Payne L S; Boger J; de Laszlo S
The selectivity of statine-based inhibitors against various human aspartic proteinases.
The Biochemical journal 1990;265(3):871-8.
1990: Kay J; Dunn B M
Viral proteinases: weakness in strength.
Biochimica et biophysica acta 1990;1048(1):1-18.
1989: Richards A D; Broadhurst A V; Ritchie A J; Dunn B M; Kay J
Inhibition of the aspartic proteinase from HIV-2.
FEBS letters 1989;253(1-2):214-6.
1989: Richards A D; Roberts R; Dunn B M; Graves M C; Kay J
Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.
FEBS letters 1989;247(1):113-7.
1989: Kem W R; Parten B; Pennington M W; Price D A; Dunn B M
Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus.
Biochemistry 1989;28(8):3483-9.
1989: Thomas D J; Richards A D; Jupp R A; Ueno E; Yamamoto K; Samloff I M; Dunn B M; Kay J
Stabilisation of cathepsin E by ATP.
FEBS letters 1989;243(2):145-8.
1988: Jupp R A; Richards A D; Kay J; Dunn B M; Wyckoff J B; Samloff I M; Yamamoto K
Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.
The Biochemical journal 1988;254(3):895-8.
1988: Pohl J; Dunn B M
Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site.
Biochemistry 1988;27(13):4827-34.
1988: Kay J; Jupp R A; Norey C G; Richards A D; Reid W A; Taggart R T; Samloff I M; Dunn B M
Aspartic proteinases and inhibitors for their control in health and disease.
Advances in experimental medicine and biology 1988;240():1-11.
1988: Kem W R; Dunn B M
Separation and characterization of four different amino acid sequence variants of a sea anemone (Stichodactyla helianthus) protein cytolysin.
Toxicon : official journal of the International Society on Toxinology 1988;26(11):997-1008.
1987: Dunn B M; Valler M J; Rolph C E; Foundling S I; Jimenez M; Kay J
The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2.
Biochimica et biophysica acta 1987;913(2):122-30.
1986: Dunn B M; Jimenez M; Parten B F; Valler M J; Rolph C E; Kay J
A systematic series of synthetic chromophoric substrates for aspartic proteinases.
The Biochemical journal 1986;237(3):899-906.
1985: Dreyer T; Valler M J; Kay J; Charlton P; Dunn B M
The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).
The Biochemical journal 1985;231(3):777-9.
1985: Valler M J; Kay J; Aoyagi T; Dunn B M
The interaction of aspartic proteinases with naturally-occurring inhibitors from actinomycetes and Ascaris lumbricoides.
Journal of enzyme inhibition 1985;1(1):77-82.

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