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Philip Dunn

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David I Fletcher; C Robin Ganellin; Alessandro Piergentili; Philip M Dunn; Donald H Jenkinson
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)).
Bei Ma; Gregory Wynn; Philip M Dunn; Geoffrey Burnstock
Increased 5-HT(3)-mediated signalling in pelvic afferent neurons from mice deficient in P2X(2) and/or P2X (3) receptor subunits.
Philip M Dunn; Joel Gever; Huai Zhen Ruan; Geoffrey Burnstock
Developmental changes in heteromeric P2X(2/3) receptor expression in rat sympathetic ganglion neurons.

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All Publications

2007: David I Fletcher; C Robin Ganellin; Alessandro Piergentili; Philip M Dunn; Donald H Jenkinson
Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)).
Bioorganic & medicinal chemistry 2007;15(16):5457-79.
2006: Bei Ma; Gregory Wynn; Philip M Dunn; Geoffrey Burnstock
Increased 5-HT(3)-mediated signalling in pelvic afferent neurons from mice deficient in P2X(2) and/or P2X (3) receptor subunits.
Purinergic signalling 2006;2(3):481-9.
2005: Philip M Dunn; Joel Gever; Huai Zhen Ruan; Geoffrey Burnstock
Developmental changes in heteromeric P2X(2/3) receptor expression in rat sympathetic ganglion neurons.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(3):505-11.
2005: Debra A Cockayne; Philip M Dunn; Yu Zhong; Weifang Rong; Sara G Hamilton; Gillian E Knight; Huai Zhen Ruan; Bei Ma; Ping Yip; Philip A Nunn; Stephen McMahon; Geoffrey Burnstock; Anthony P D W Ford
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP.
The Journal of physiology 2005;567(Pt 2):621-39.
2005: Bei Ma; Huai Zhen Ruan; Geoffrey Burnstock; Philip M Dunn
Differential expression of P2X receptors on neurons from different parasympathetic ganglia.
Neuropharmacology 2005;48(5):766-77.
2005: Robson Coutinho-Silva; David M Ojcius; Darek C Górecki; Pedro Persechini; Rodrigo C Bisaggio; Anderson N Mendes; Joanne Marks; Geoffrey Burnstock; Philip M Dunn
Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages.
Biochemical pharmacology 2005;69(4):641-55.
2004: Mina Ryten; Shi-Yu Yang; Philip M Dunn; Geoffrey Goldspink; Geoffrey Burnstock
Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1404-6.
2004: Dimitrios Galanakis; C Robin Ganellin; Jian-Quing Chen; Diyan Gunasekera; Philip M Dunn
Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons.
Bioorganic & medicinal chemistry letters 2004;14(16):4231-5.
2004: Bei Ma; Huai Zhen Ruan; Debra A Cockayne; Anthony P D W Ford; Geoffrey Burnstock; Philip M Dunn
Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies.
Neuropharmacology 2004;46(7):1039-48.
2003: Kate A Hillman; Hitoshi Harada; Choong M Chan; Andrea Townsend-Nicholson; Stephen E Moss; Kengo Miyamoto; Yasunobu Suketa; Geoffrey Burnstock; Robert J Unwin; Philip M Dunn
Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: a system suitable for the study of purine receptor-mediated cell death.
Biochemical pharmacology 2003;66(3):415-24.
2002: Mina Ryten; Philip M Dunn; Joseph T Neary; Geoffrey Burnstock
ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.
The Journal of cell biology 2002;158(2):345-55.
2001: Y Zhong; Philip M Dunn; M Bardini; Anthony P D W Ford; Debra A Cockayne; Geoffrey Burnstock
Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice.
The European journal of neuroscience 2001;14(11):1784-92.
2001: Philip M Dunn; Y Zhong; Geoffrey Burnstock
P2X receptors in peripheral neurons.
Progress in neurobiology 2001;65(2):107-34.
2001: Ramine Hosseini; David C H Benton; Philip M Dunn; Donald H Jenkinson; Guy W J Moss
SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones.
The Journal of physiology 2001;535(Pt 2):323-34.
2001: Min Liu; Brian F King; Philip M Dunn; Weifang Rong; Andrea Townsend-Nicholson; Geoffrey Burnstock
Coexpression of P2X(3) and P2X(2) receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons.
The Journal of pharmacology and experimental therapeutics 2001;296(3):1043-50.
2001: Y Zhong; Philip M Dunn; Geoffrey Burnstock
Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties.
British journal of pharmacology 2001;132(1):221-33.
2000: Debra A Cockayne; S G Hamilton; Quan-Ming Zhu; Philip M Dunn; Y Zhong; SD Novakovic; A B Malmberg; G Cain; A Berson; LC Kassotakis; LR Hedley; WG Lachnit; G Burnstock; Stephen McMahon; Anthony P D W Ford
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice.
Nature 2000;407(6807):1011-5.
2000: J Q Chen; Dimitrios Galanakis; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.
Journal of medicinal chemistry 2000;43(19):3478-81.
2000: Philip M Dunn; Min Liu; Y Zhong; Brian F King; Geoffrey Burnstock
Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones.
British journal of pharmacology 2000;130(6):1378-84.
2000: Y Zhong; Philip M Dunn; Geoffrey Burnstock
Guinea-pig sympathetic neurons express varying proportions of two distinct P2X receptors.
The Journal of physiology 2000;523 Pt 2():391-402.
2000: J Campos Rosa; Dimitrios Galanakis; Alessandro Piergentili; K Bhandari; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel.
Journal of medicinal chemistry 2000;43(3):420-31.
2000: Y Zhong; Philip M Dunn; Geoffrey Burnstock
Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons.
Neuropharmacology 2000;39(2):172-80.
1999: Min Liu; Philip M Dunn; Brian F King; Geoffrey Burnstock
Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology.
British journal of pharmacology 1999;128(1):61-8.
1999: Philip M Dunn
UCL 1684: a potent blocker of Ca2+ -activated K+ channels in rat adrenal chromaffin cells in culture.
European journal of pharmacology 1999;368(1):119-23.
1998: Y Zhong; Philip M Dunn; Zhenghua Xiang; X Bo; Geoffrey Burnstock
Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons.
British journal of pharmacology 1998;125(4):771-81.
1998: Philip M Dunn
The action of blocking agents applied to the inner face of Ca(2+)-activated K+ channels from human erythrocytes.
The Journal of membrane biology 1998;165(2):133-43.
1998: J C Rosa; Dimitrios Galanakis; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel.
Journal of medicinal chemistry 1998;41(1):2-5.
1996: Dimitrios Galanakis; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
On the concept of a bivalent pharmacophore for SKCa channel blockers: synthesis, pharmacological testing, and radioligand binding studies on mono-, bis-, and tris-quinolinium compounds.
Archiv der Pharmazie 1996;329(12):524-8.
1996: J Campos Rosa; Dimitrios Galanakis; C Robin Ganellin; Philip M Dunn
Synthesis, molecular modeling, and K+ channel-blocking activity of dequalinium analogues having semirigid linkers.
Journal of medicinal chemistry 1996;39(21):4247-54.
1996: Dimitrios Galanakis; C Robin Ganellin; S Malik; Philip M Dunn
Synthesis and pharmacological testing of dequalinium analogues as blockers of the apamin-sensitive Ca(2+)-activated K+ channel: variation of the length of the alkylene chain.
Journal of medicinal chemistry 1996;39(18):3592-5.
1996: C J Roxburgh; C Robin Ganellin; M A Shiner; D C Benton; Philip M Dunn; Y Ayalew; Donald H Jenkinson
The synthesis and some pharmacological actions of the enantiomers of the K(+)-channel blocker cetiedil.
The Journal of pharmacy and pharmacology 1996;48(8):851-7.
1996: Dimitrios Galanakis; C A Davis; C Robin Ganellin; Philip M Dunn
Synthesis and quantitative structure-activity relationship of a novel series of small conductance Ca(2+)-activated K+ channel blockers related to dequalinium.
Journal of medicinal chemistry 1996;39(2):359-70.
1996: Philip M Dunn; D C Benton; J Campos Rosa; C Robin Ganellin; Donald H Jenkinson
Discrimination between subtypes of apamin-sensitive Ca(2+)-activated K+ channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530.
British journal of pharmacology 1996;117(1):35-42.
1995: Dimitrios Galanakis; J A Calder; C Robin Ganellin; C S Owen; Philip M Dunn
Synthesis and quantitative structure-activity relationships of dequalinium analogues as K+ channel blockers: investigation into the role of the substituent at position 4 of the quinoline ring.
Journal of medicinal chemistry 1995;38(18):3536-46.
1995: Dimitrios Galanakis; C A Davis; B Del Rey Herrero; C Robin Ganellin; Philip M Dunn; Donald H Jenkinson
Synthesis and structure-activity relationships of dequalinium analogues as K+ channel blockers. Investigations on the role of the charged heterocycle.
Journal of medicinal chemistry 1995;38(4):595-606.
1994: Philip M Dunn
Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurones in culture.
European journal of pharmacology 1994;252(2):189-94.
1993: Philip M Dunn
Ganglion-blocking activity of dequalinium in frog and rat sympathetic ganglia in vitro.
European journal of pharmacology 1993;230(3):335-9.