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David Dunne

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Shona Wilson; Aissata Doucouré; Hassan K M Fofana; Frances M Jones; Gachuhi Kimani; Aly Landouré; Joseph K Mwatha; Moussa Sacko; Birgitte J Vennervald; David W Dunne
Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils.
Angela Pinot de Moira; Jose C Sousa-Figueiredo; J Russell Stothard; Martha Betson; Colin M Fitzsimmons; Frances M Jones; Narcis B Kabatereine; David W Dunne
Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.
Angela Pinot de Moira; Edridah M Tukahebwa; Shona Wilson; Jeffrey M Bethony; Colin M Fitzsimmons; Frances M Jones; Narcis B Kabatereine; Joseph K Mwatha; David W Dunne
Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections.

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All Publications

2013: Shona Wilson; Aissata Doucouré; Hassan K M Fofana; Frances M Jones; Gachuhi Kimani; Aly Landouré; Joseph K Mwatha; Moussa Sacko; Birgitte J Vennervald; David W Dunne
Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils.
PLoS neglected tropical diseases 2013;7(3):e2149.
2013: Angela Pinot de Moira; Jose C Sousa-Figueiredo; J Russell Stothard; Martha Betson; Colin M Fitzsimmons; Frances M Jones; Narcis B Kabatereine; David W Dunne
Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.
The Journal of infectious diseases 2013;207(2):362-6.
2013: Angela Pinot de Moira; Edridah M Tukahebwa; Shona Wilson; Jeffrey M Bethony; Colin M Fitzsimmons; Frances M Jones; Narcis B Kabatereine; Joseph K Mwatha; David W Dunne
Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections.
Infection and immunity 2013;81(1):23-32.
2012: Colin M Fitzsimmons; Frances M Jones; Jamal Khalife; Angela Pinot de Moira; Anna V Protasio; Edridah M Tukahebwa; Harriet A Dickinson; David W Dunne
Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?
Infection and immunity 2012;80(12):4264-70.
2012: Yun Yun Gong; H Curtis Kariuki; Gachuhi Kimani; Joseph K Mwatha; Michael N Routledge; Birgitte J Vennervald; Jovita M Castelino; David W Dunne; Shona Wilson; Bin Zhao; Christopher P Wild
Aflatoxin exposure may contribute to chronic hepatomegaly in Kenyan school children.
Environmental health perspectives 2012;120(6):893-6.
2012: Shona Wilson; David W Dunne
Advances in our understanding of the epidemiology of Plasmodium and schistosome infection: informing coinfection studies.
Current opinion in HIV and AIDS 2012;7(3):225-30.
2012: Angela van Diepen; Loes van Egmond; David W Dunne; Narcis B Kabatereine; Angela Pinot de Moira; Cornelis H Smit; Cornelis H Hokke
Differential anti-glycan antibody responses in Schistosoma mansoni-infected children and adults studied by shotgun glycan microarray.
PLoS neglected tropical diseases 2012;6(11):e1922.
2012: Colin M Fitzsimmons; Karl F Hoffmann; Frances M Jones; Narcis B Kabatereine; Alex Stearn; Jakub Wawrzyniak; Shona Wilson; Iain W Chalmers; David W Dunne
The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses.
PLoS neglected tropical diseases 2012;6(4):e1593.
2011: Paola Zaccone; Oliver T Burton; Michael J Doenhoff; David W Dunne; Sarah E Gibbs; Helmut Haas; Frances M Jones; Nigel Miller; Gabriele Schramm; Anne Cooke
The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4⁺ T cells.
European journal of immunology 2011;41(9):2709-18.
2011: Shona Wilson; Birgitte J Vennervald; David W Dunne
Chronic hepatosplenomegaly in African school children: a common but neglected morbidity associated with schistosomiasis and malaria.
PLoS neglected tropical diseases 2011;5(8):e1149.
2011: Harriet Mpairwe; Emily L Webb; Lawrence Muhangi; Juliet Ndibazza; Denise Akishule; Margaret Nampijja; Sophy Ngom-wegi; Josephine Tumusime; Frances M Jones; Colin M Fitzsimmons; David W Dunne; Moses Muwanga; Laura C Rodrigues; Alison M Elliott
Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2011;22(3):305-12.
2011: Angela Pinot de Moira; Narcis B Kabatereine; David W Dunne; Mark Booth
Understanding ethnic differences in behaviour relating to Schistosoma mansoni re-infection after mass treatment.
Journal of biosocial science 2011;43(2):185-209.
2011: Robert Tweyongyere; Birgitte J Vennervald; Emily L Webb; Stephen Cose; David W Dunne; Frances M Jones; Macklyn Kihembo; Patrice A Mawa; Alison M Elliott
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.
BMC infectious diseases 2011;11():234.
2010: Oliver T Burton; Sarah Gibbs; Nigel Miller; Frances M Jones; Li Wen; David W Dunne; Anne Cooke; Paola Zaccone
Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.
European journal of immunology 2010;40(8):2221-9.
2010: Dean Everett; Kathy J Baisely; Ruth McNerney; Ian Hambleton; Tobias Chirwa; David A Ross; John Changalucha; Deborah Watson-Jones; Helena Helmby; David W Dunne; David Mabey; Richard J Hayes
Association of schistosomiasis with false-positive HIV test results in an African adolescent population.
Journal of clinical microbiology 2010;48(5):1570-7.
2010: Shona Wilson; Birgitte J Vennervald; Hilda Kadzo; Edmund Ireri; Clifford Amaganga; Mark Booth; H Curtis Kariuki; Joseph K Mwatha; Gachuhi Kimani; John H Ouma; Eric Muchiri; David W Dunne
Health implications of chronic hepatosplenomegaly in Kenyan school-aged children chronically exposed to malarial infections and Schistosoma mansoni.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2010;104(2):110-6.
2010: Angela Pinot de Moira; Anthony J C Fulford; Narcis B Kabatereine; John H Ouma; Mark Booth; David W Dunne
Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE.
PLoS neglected tropical diseases 2010;4(9):.
2010: Paola Zaccone; Oliver T Burton; Sarah Gibbs; Nigel Miller; Frances M Jones; David W Dunne; Anne Cooke
Immune modulation by Schistosoma mansoni antigens in NOD mice: effects on both innate and adaptive immune systems.
Journal of biomedicine & biotechnology 2010;2010():795210.
2009: Colin M Fitzsimmons; David W Dunne
Survival of the fittest: allergology or parasitology?
Trends in parasitology 2009;25(10):447-51.
2009: Paola Zaccone; Oliver Burton; Nigel Miller; Frances M Jones; David W Dunne; Anne Cooke
Schistosoma mansoni egg antigens induce Treg that participate in diabetes prevention in NOD mice.
European journal of immunology 2009;39(4):1098-107.
2009: S Wilson; Frances M Jones; Joseph K Mwatha; Gachuhi Kimani; Mark Booth; H Curtis Kariuki; Birgitte J Vennervald; John H Ouma; Eric Muchiri; David W Dunne
Hepatosplenomegaly associated with chronic malaria exposure: evidence for a pro-inflammatory mechanism exacerbated by schistosomiasis.
Parasite immunology 2009;31(2):64-71.
2009: Robert Tweyongyere; Patrice A Mawa; Nicholas O Emojong; Harriet Mpairwe; Frances M Jones; Trinh Duong; David W Dunne; Birgitte J Vennervald; E Katunguka-Rwakishaya; Alison M Elliott
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial.
BMC infectious diseases 2009;9():32.
2008: Robert Tweyongyere; Patrice A Mawa; Sophy Ngom-Wegi; Juliet Ndibazza; Trinh Duong; Birgitte J Vennervald; David W Dunne; Eli Katunguka-Rwakishaya; Alison M Elliott
Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens: results of a randomized, placebo-controlled trial.
The Journal of infectious diseases 2008;198(12):1870-9.
2008: Shona Wilson; Frances M Jones; Joseph K Mwatha; Gachuhi Kimani; Mark Booth; H Curtis Kariuki; Birgitte J Vennervald; John H Ouma; Eric Muchiri; David W Dunne
Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection.
Infection and immunity 2008;76(5):2212-8.
2008: Claus Reimert; Edridah M Tukahebwa; Narcis B Kabatereine; David W Dunne; Birgitte J Vennervald
Assessment of Schistosoma mansoni induced intestinal inflammation by means of eosinophil cationic protein, eosinophil protein X and myeloperoxidase before and after treatment with praziquantel.
Acta tropica 2008;105(3):253-9.
2008: Akhmed Aslam; Phyllis Quinn; Richard S McIntosh; Jianguo Shi; Ashfaq Ghumra; James H McKerrow; Karen A Bunting; David W Dunne; Michael J Doenhoff; Sherie L Morrison; Ke Zhang; Richard J Pleass
Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.
Molecular immunology 2008;45(2):567-74.
2007: Shona Wilson; Birgitte J Vennervald; Hilda Kadzo; Edmund Ireri; Clifford Amaganga; Mark Booth; H Curtis Kariuki; Joseph K Mwatha; Gachuhi Kimani; John H Ouma; Eric Muchiri; David W Dunne
Hepatosplenomegaly in Kenyan schoolchildren: exacerbation by concurrent chronic exposure to malaria and Schistosoma mansoni infection.
Tropical medicine & international health : TM & IH 2007;12(12):1442-9.
2007: Angela Pinot de Moira; Anthony J C Fulford; Narcis B Kabatereine; Francis Kazibwe; John H Ouma; David W Dunne; Mark Booth
Microgeographical and tribal variations in water contact and Schistosoma mansoni exposure within a Ugandan fishing community.
Tropical medicine & international health : TM & IH 2007;12(6):724-35.
2007: Shona Wilson; Mark Booth; Frances M Jones; Joseph K Mwatha; Gachuhi Kimani; H Curtis Kariuki; Birgitte J Vennervald; John H Ouma; Eric Muchiri; David W Dunne
Age-adjusted Plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to Plasmodium infection.
BMC infectious diseases 2007;7():67.
2007: Colin M Fitzsimmons; Rowena McBeath; Sarah Joseph; Frances M Jones; Klaudia Walter; Karl F Hoffmann; H Curtis Kariuki; Joseph K Mwatha; Gachuhi Kimani; Narcis B Kabatereine; Birgitte J Vennervald; John H Ouma; David W Dunne
Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure.
International archives of allergy and immunology 2007;142(1):40-50.
2006: Klaudia Walter; Anthony J C Fulford; Rowena McBeath; Sarah Joseph; Frances M Jones; H Curtis Kariuki; Joseph K Mwatha; Gachuhi Kimani; Narcis B Kabatereine; Birgitte J Vennervald; John H Ouma; David W Dunne
Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5490-8.
2006: Paola Zaccone; Zoltan Fehervari; Jenny M Phillips; David W Dunne; Anne Cooke
Parasitic worms and inflammatory diseases.
Parasite immunology 2006;28(10):515-23.
2006: Richard S McIntosh; Frances M Jones; David W Dunne; James H McKerrow; Richard J Pleass
Characterization of immunoglobulin binding by schistosomes.
Parasite immunology 2006;28(9):407-19.
2006: Christine Pierrot; Shona Wilson; Hélène Lallet; Sophia Lafitte; Frances M Jones; Wassim Daher; Monique Capron; David W Dunne; Jamal Khalife
Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria.
Infection and immunity 2006;74(6):3347-54.
2006: Mark Booth; Marie-Anne Shaw; Danielle Carpenter; Sarah Joseph; Narcis B Kabatereine; H Curtis Kariuki; Joseph K Mwatha; Frances M Jones; Birgitte J Vennervald; John H Ouma; David W Dunne
Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7112-8.
2006: Michael Brown; George Miiro; Peter Nkurunziza; Christine Watera; Maria A Quigley; David W Dunne; James A G Whitworth; Alison M Elliott
Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans.
The American journal of tropical medicine and hygiene 2006;74(5):819-25.
2006: Claus Reimert; Colin M Fitzsimmons; Sarah Joseph; Joseph K Mwatha; Frances M Jones; Gachuhi Kimani; Karl F Hoffmann; Mark Booth; Narcis B Kabatereine; David W Dunne; Birgitte J Vennervald
Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel.
Clinical and vaccine immunology : CVI 2006;13(5):584-93.
2006: Manfred Wuhrer; Crina I A Balog; M Isabel Catalina; Frances M Jones; Gabriele Schramm; Helmut Haas; Michael J Doenhoff; David W Dunne; André M Deelder; Cornelis H Hokke
IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans.
The FEBS journal 2006;273(10):2276-92.
2006: David W Dunne; Birgitte J Vennervald; Mark Booth; Sarah Joseph; Colin M Fitzsimmons; Pierre Cahen; Robert F Sturrock; John H Ouma; Joseph K Mwatha; Gachuhi Kimani; H Curtis Kariuki; Francis Kazibwe; Edridah M Tukahebwa; Narcis B Kabatereine
Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100(3):216-23.
2005: Colin M Fitzsimmons; Gabriele Schramm; Frances M Jones; Iain W Chalmers; Karl F Hoffmann; Christoph G Grevelding; Manfred Wuhrer; Cornelis H Hokke; Helmut Haas; Michael J Doenhoff; David W Dunne
Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.
Molecular and biochemical parasitology 2005;144(1):123-7.
2005: Michael Brown; Patrice A Mawa; Sarah Joseph; Joseph Bukusuba; Christine Watera; James A G Whitworth; David W Dunne; Alison M Elliott
Treatment of Schistosoma mansoni infection increases helminth-specific type 2 cytokine responses and HIV-1 loads in coinfected Ugandan adults.
The Journal of infectious diseases 2005;191(10):1648-57.
2005: David W Dunne; Anne Cooke
A worm's eye view of the immune system: consequences for evolution of human autoimmune disease.
Nature reviews. Immunology 2005;5(5):420-6.
2005: Jennifer M Fitzpatrick; David A Johnston; Gary W Williams; Debbie J Williams; Tom C Freeman; David W Dunne; Karl F Hoffmann
An oligonucleotide microarray for transcriptome analysis of Schistosoma mansoni and its application/use to investigate gender-associated gene expression.
Molecular and biochemical parasitology 2005;141(1):1-13.
2005: Birgitte J Vennervald; Mark Booth; Anthony Butterworth; H Curtis Kariuki; Hilda Kadzo; Edmund Ireri; Clifford Amaganga; Gachuhi Kimani; LeeCarol Kenty; Joseph K Mwatha; John H Ouma; David W Dunne
Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2005;99(2):150-60.
2004: Mark Booth; David W Dunne
Spatial awareness in parasite immuno-epidemiology.
Parasite immunology 2004;26(11-12):499-507.
2004: Tim Raine; Paola Zaccone; David W Dunne; Anne Cooke
Can helminth antigens be exploited therapeutically to downregulate pathological Th1 responses?
Current opinion in investigational drugs (London, England : 2000) 2004;5(11):1184-91.
2004: Mark Booth; Birgitte J Vennervald; Anthony Butterworth; H Curtis Kariuki; Clifford Amaganga; Gachuhi Kimani; Joseph K Mwatha; Amos Otedo; John H Ouma; David W Dunne
Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children.
BMC medicine 2004;2():36.
2004: Johannes J P M Bogers; Shyama Chatterjee; Werner Jacobs; Padraic G Fallon; David W Dunne; Jan A M Langermans; André M Deelder; Alan Thomas; Eric A Van Marck
Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni.
Virchows Archiv : an international journal of pathology 2004;445(3):285-91.
2004: Sarah Joseph; Frances M Jones; Klaudia Walter; Anthony J C Fulford; Gachuhi Kimani; Joseph K Mwatha; Timothy Kamau; H Curtis Kariuki; Francis Kazibwe; Edridah M Tukahebwa; Narcis B Kabatereine; John H Ouma; Birgitte J Vennervald; David W Dunne
Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel.
The Journal of infectious diseases 2004;190(4):835-42.
2004: Colin M Fitzsimmons; T J Stewart; Karl F Hoffmann; Jane Grogan; Maria Yazdanbakhsh; David W Dunne
Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.
Parasite immunology 2004;26(8-9):371-6.
2004: Jennifer M Fitzpatrick; Maria Vang Johansen; David A Johnston; David W Dunne; Karl F Hoffmann
Gender-associated gene expression in two related strains of Schistosoma japonicum.
Molecular and biochemical parasitology 2004;136(2):191-209.
2004: Sarah Joseph; Frances M Jones; Maureen E Laidlaw; Gamal Mohamed; Patrice A Mawa; Proscovia B Namujju; Moses Kizza; Christine Watera; James A G Whitworth; David W Dunne; Alison M Elliott
Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
The Journal of infectious diseases 2004;190(3):613-8.
2004: Colin M Fitzsimmons; Sarah Joseph; Frances M Jones; Claus Reimert; Karl F Hoffmann; Francis Kazibwe; Gachuhi Kimani; Joseph K Mwatha; John H Ouma; Edridah M Tukahebwa; H Curtis Kariuki; Birgitte J Vennervald; Narcis B Kabatereine; David W Dunne
Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E.
Infection and immunity 2004;72(7):4023-30.
2004: Anne Cooke; Paola Zaccone; Tim Raine; Jenny M Phillips; David W Dunne
Infection and autoimmunity: are we winning the war, only to lose the peace?
Trends in parasitology 2004;20(7):316-21.
2004: Mark Booth; Birgitte J Vennervald; LeeCarol Kenty; Anthony Butterworth; H Curtis Kariuki; Hilda Kadzo; Edmund Ireri; Clifford Amaganga; Gachuhi Kimani; Joseph K Mwatha; Amos Otedo; John H Ouma; Eric Muchiri; David W Dunne
Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children.
BMC infectious diseases 2004;4():13.
2004: Mohamed Z Satti; Pierre Cahen; Per Stahl Skov; Sarah Joseph; Frances M Jones; Colin M Fitzsimmons; Karl F Hoffmann; Claus Reimert; H Curtis Kariuki; Francis Kazibwe; Joseph K Mwatha; Gachuhi Kimani; Birgitte J Vennervald; John H Ouma; Narcis B Kabatereine; David W Dunne
Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel.
BMC immunology 2004;5():6.
2004: Birgitte J Vennervald; LeeCarol Kenty; Anthony Butterworth; Curtis H Kariuki; Hilda Kadzo; Edmund Ireri; Clifford Amaganga; Gachuhi Kimani; Joseph K Mwatha; Amos Otedo; Mark Booth; John H Ouma; David W Dunne
Detailed clinical and ultrasound examination of children and adolescents in a Schistosoma mansoni endemic area in Kenya: hepatosplenic disease in the absence of portal fibrosis.
Tropical medicine & international health : TM & IH 2004;9(4):461-70.
2004: Mark Booth; Birgitte J Vennervald; Narcis B Kabatereine; Francis Kazibwe; John H Ouma; Curtis H Kariuki; Eric Muchiri; Hilda Kadzo; Edmund Ireri; Gachuhi Kimani; Joseph K Mwatha; David W Dunne
Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2004;98(2):125-36.
2004: Sarah Joseph; Frances M Jones; Gachuhi Kimani; Joseph K Mwatha; Timothy Kamau; Francis Kazibwe; Jovanice Kemijumbi; Narcis B Kabatereine; Mark Booth; H Curtis Kariuki; John H Ouma; Birgitte J Vennervald; David W Dunne
Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens.
Infection and immunity 2004;72(2):728-34.
2004: Mark Booth; Joseph K Mwatha; Sarah Joseph; Frances M Jones; Hilda Kadzo; Edmund Ireri; Francis Kazibwe; Jovanice Kemijumbi; Curtis H Kariuki; Gachuhi Kimani; John H Ouma; Narcis B Kabatereine; Birgitte J Vennervald; David W Dunne
Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1295-303.
2004: Margaret M Mentink-Kane; Allen W Cheever; Robert W Thompson; Danielle M Hari; Narcis B Kabatereine; Birgitte J Vennervald; John H Ouma; Joseph K Mwatha; Frances M Jones; Debra D Donaldson; Michael J Grusby; David W Dunne; Thomas A Wynn
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):586-90.
2004: T David; C Thomas; Paola Zaccone; David W Dunne; Anne Cooke
The impact of infection on the incidence of autoimmune disease.
Current topics in medicinal chemistry 2004;4(5):521-9.
2003: Cynthia W A Naus; Alexandra Van Remoortere; John H Ouma; Gachuhi Kimani; David W Dunne; Johannis P Kamerling; André M Deelder; Cornelis H Hokke
Specific antibody responses to three schistosome-related carbohydrate structures in recently exposed immigrants and established residents in an area of Schistosoma mansoni endemicity.
Infection and immunity 2003;71(10):5676-81.
2003: Narcis B Kabatereine; Jovanice Kemijumbi; John H Ouma; Robert F Sturrock; Anthony Butterworth; H Madsen; N Ornbjerg; David W Dunne; B J Vennnervald
Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(5):599-603.
2003: Cynthia W A Naus; Mark Booth; Frances M Jones; Jovanice Kemijumbi; Birgitte J Vennervald; Curtis H Kariuki; John H Ouma; Narcis B Kabatereine; David W Dunne
The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community.
Tropical medicine & international health : TM & IH 2003;8(6):561-8.
2003: Paola Zaccone; Zoltán Fehérvári; Frances M Jones; Stéphane Sidobre; Mitchell Kronenberg; David W Dunne; Anne Cooke
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes.
European journal of immunology 2003;33(5):1439-49.
2003: Joseph K Mwatha; Frances M Jones; Gamal Mohamed; Cynthia W A Naus; Eleanor M Riley; Anthony Butterworth; Gachuhi Kimani; Curtis H Kariuki; John H Ouma; Davy K Koech; David W Dunne
Associations between anti-Schistosoma mansoni and anti-Plasmodium falciparum antibody responses and hepatosplenomegaly, in Kenyan schoolchildren.
The Journal of infectious diseases 2003;187(8):1337-41.
2003: Cynthia W A Naus; Frances M Jones; Mohamed Z Satti; Sarah Joseph; Eleanor M Riley; Gachuhi Kimani; Joseph K Mwatha; Curtis H Kariuki; John H Ouma; Narcis B Kabatereine; Birgitte J Vennervald; David W Dunne
Serological responses among individuals in areas where both schistosomiasis and malaria are endemic: cross-reactivity between Schistosoma mansoni and Plasmodium falciparum.
The Journal of infectious diseases 2003;187(8):1272-82.
2003: Padraic G Fallon; Jason Gibbons; Richard Vervenne; Emma J Richardson; Anthony J C Fulford; Simon Kiarie; Robert F Sturrock; Patricia S Coulson; André M Deelder; Jan A M Langermans; Alan Thomas; David W Dunne
Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni.
The Journal of infectious diseases 2003;187(6):939-45.
2003: Karl F Hoffmann; David W Dunne
Characterization of the Schistosoma transcriptome opens up the world of helminth genomics.
Genome biology 2003;5(1):203.
2003: Alison M Elliott; Patrice A Mawa; Sarah Joseph; Proscovia B Namujju; Moses Kizza; Jessica Nakiyingi; Christine Watera; David W Dunne; James A G Whitworth
Associations between helminth infection and CD4+ T cell count, viral load and cytokine responses in HIV-1-infected Ugandan adults.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003;97(1):103-8.
2002: Karl F Hoffmann; David A Johnston; David W Dunne
Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling.
Genome biology 2002;3(8):RESEARCH0041.
2002: Walderez O Dutra; Rodrigo Correa-Oliveira; David W Dunne; Luiza Fosenca Cecchini; Lúcia A O Fraga; Morven Roberts; Alda Maria Soares-Silveira; Michelle Webster; Hans Yssel; Kenneth Gollob
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients.
BMC immunology 2002;3():8.
2002: Karl F Hoffmann; Thomas A Wynn; David W Dunne
Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology.
Advances in parasitology 2002;52():265-307.
2001: Philip Smith; David W Dunne; Padraic G Fallon
Defective in vivo induction of functional type 2 cytokine responses in aged mice.
European journal of immunology 2001;31(5):1495-502.
2000: Padraic G Fallon; Philip Smith; Emma J Richardson; F J Jones; Helen Faulkner; Jacques Van Snick; Jean-Christophe Renauld; Richard K Grencis; David W Dunne
Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections.
Infection and immunity 2000;68(10):6005-11.
2000: L R Brunet; S Joseph; David W Dunne; B Fried
Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni.
Parasitology 2000;120 ( Pt 6)():565-71.
2000: Padraic G Fallon; Emma J Richardson; Philip Smith; David W Dunne
Elevated type 1, diminished type 2 cytokines and impaired antibody response are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice.
European journal of immunology 2000;30(2):470-80.
1999: M G Hernandez; Julius Hafalla; Luz P Acosta; F F Aligui; Gemiliano Aligui; BL Ramirez; David W Dunne; ML Santiago
Paramyosin is a major target of the human IgA response against Schistosoma japonicum.
Parasite immunology 1999;21(12):641-7.
1999: Cynthia W A Naus; Gachuhi Kimani; John H Ouma; Anthony J C Fulford; M Webster; Govert van Dam; André M Deelder; Anthony Butterworth; David W Dunne
Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age.
Infection and immunity 1999;67(7):3444-51.
1999: David W Dunne; E J Pearce
Immunology of hepatosplenic schistosomiasis mansoni: a human perspective.
Microbes and infection / Institut Pasteur 1999;1(7):553-60.
1999: Anne Cooke; P Tonks; Frances M Jones; Helen O'Shea; Patricia Hutchings; Anthony J C Fulford; David W Dunne
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice.
Parasite immunology 1999;21(4):169-76.
1999: Padraic G Fallon; David W Dunne
Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):4122-32.
1999: Julius Hafalla; J G Alamares; Luz P Acosta; David W Dunne; BL Ramirez; ML Santiago
Molecular identification of a 21.7 kDa schistosoma japonicum antigen as a target of the human IgE response.
Molecular and biochemical parasitology 1999;98(1):157-61.
1999: Narcis B Kabatereine; Birgitte J Vennervald; John H Ouma; Jovanice Kemijumbi; Anthony Butterworth; David W Dunne; Anthony J C Fulford
Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns.
Parasitology 1999;118 ( Pt 1)():101-5.
1998: ML Santiago; Julius Hafalla; Jonathan D Kurtis; Gemiliano Aligui; Peter M Wiest; Remigio M Olveda; G Richard Olds; David W Dunne; BL Ramirez
Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the human IgE response: similarity of IgE-binding epitopes to allergen peptides.
International archives of allergy and immunology 1998;117(2):94-104.
1998: John H Ouma; Anthony J C Fulford; H Curtis Kariuki; Gachuhi Kimani; Robert F Sturrock; G Muchemi; Anthony Butterworth; David W Dunne
The development of schistosomiasis mansoni in an immunologically naive immigrant population in Masongaleni, Kenya.
Parasitology 1998;117 ( Pt 2)():123-32.
1998: M Webster; M Roberts; Anthony J C Fulford; M Marguerite; M C Gallisot; M Diagne; M Niang; Gilles Riveau; André Capron; David W Dunne
Human IgE responses to rSm22.6 are associated with infection intensity rather than age per se, in a recently established focus of Schistomiasis mansoni.
Tropical medicine & international health : TM & IH 1998;3(4):318-26.
1998: Padraic G Fallon; Philip Smith; David W Dunne
Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection.
European journal of immunology 1998;28(4):1408-16.
1998: Padraic G Fallon; Emma J Richardson; Frances M Jones; David W Dunne
Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni.
Clinical and diagnostic laboratory immunology 1998;5(2):251-3.
1998: Joseph K Mwatha; Gachuhi Kimani; Timothy Kamau; GG Mbugua; John H Ouma; J Mumo; Anthony J C Fulford; Frances M Jones; Anthony Butterworth; M B Roberts; David W Dunne
High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1992-9.
1998: Anthony J C Fulford; M Webster; John H Ouma; Gachuhi Kimani; David W Dunne
Puberty and Age-related Changes in Susceptibility to Schistosome Infection.
Parasitology today (Personal ed.) 1998;14(1):23-6.
1997: M Webster; Rodrigo Correa-Oliveira; Giovanni Gazzinelli; IR Viana; Lúcia A O Fraga; Alda M S Silveira; David W Dunne
Factors affecting high and low human IgE responses to schistosome worm antigens in an area of Brazil endemic for Schistosoma mansoni and hookworm.
The American journal of tropical medicine and hygiene 1997;57(4):487-94.
1997: M Webster; Padraic G Fallon; Anthony J C Fulford; Anthony Butterworth; John H Ouma; Gachuhi Kimani; David W Dunne
Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm.
Parasite immunology 1997;19(7):333-5.
1997: M Webster; B D Libranda-Ramirez; Gemiliano Aligui; Remigio M Olveda; John H Ouma; H Curtis Kariuki; Gachuhi Kimani; G Richard Olds; Anthony J C Fulford; Anthony Butterworth; David W Dunne
The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines.
Parasitology 1997;114 ( Pt 4)():383-93.
1997: M Webster; Padraic G Fallon; Anthony J C Fulford; Anthony Butterworth; John H Ouma; Gachuhi Kimani; David W Dunne
IgG4 and IgE responses to Schistosoma mansoni adult worms after treatment.
The Journal of infectious diseases 1997;175(2):493-4.
1997: David W Dunne; M Webster; P Smith; J G Langley; B A Richardson; Anthony J C Fulford; Anthony Butterworth; Robert F Sturrock; H Curtis Kariuki; John H Ouma
The isolation of a 22 kDa band after SDS-PAGE of Schistosoma mansoni adult worms and its use to demonstrate that IgE responses against the antigen(s) it contains are associated with human resistance to reinfection.
Parasite immunology 1997;19(2):79-89.
1996: Anthony Butterworth; David W Dunne; Anthony J C Fulford; J H Ouma; Robert F Sturrock
Immunity and morbidity in Schistosoma mansoni infection: quantitative aspects.
The American journal of tropical medicine and hygiene 1996;55(5 Suppl):109-15.
1996: M Webster; Anthony J C Fulford; G Braun; J H Ouma; H Curtis Kariuki; J C Havercroft; K Gachuhi; Robert F Sturrock; Anthony Butterworth; David W Dunne
Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment.
Infection and immunity 1996;64(10):4042-6.
1995: David W Dunne; P Hagan; F G Abath
Prospects for immunological control of schistosomiasis.
Lancet 1995;345(8963):1488-91.
1995: A J Curry; Kathryn J Else; F Jones; Allison J Bancroft; Richard K Grencis; David W Dunne
Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris.
The Journal of experimental medicine 1995;181(2):769-74.
1994: David W Dunne; Frances M Jones; L Cook; N A Moloney
Passively transferable protection against Schistosoma japonicum induced in the mouse by multiple vaccination with attenuated larvae: the development of immunity, antibody isotype responses and antigen recognition.
Parasite immunology 1994;16(12):655-68.
1994: J G Langley; H Curtis Kariuki; A P Hammersley; J H Ouma; Anthony Butterworth; David W Dunne
Human IgG subclass responses and subclass restriction to Schistosoma mansoni egg antigens.
Immunology 1994;83(4):651-8.
1994: Anthony Butterworth; A J Curry; David W Dunne; Anthony J C Fulford; Gachuhi Kimani; H Curtis Kariuki; R Klumpp; Davy K Koech; G Mbugua; J H Ouma
Immunity and morbidity in human schistosomiasis mansoni.
Tropical and geographical medicine 1994;46(4 Spec No):197-208.
1993: M Roberts; Anthony Butterworth; Gachuhi Kimani; T Kamau; Anthony J C Fulford; David W Dunne; J H Ouma; Robert F Sturrock
Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection.
Infection and immunity 1993;61(12):4984-93.
1993: David W Dunne; B A Richardson; Frances M Jones; M Clark; K J Thorne; Anthony Butterworth
The use of mouse/human chimaeric antibodies to investigate the roles of different antibody isotypes, including IgA2, in the killing of Schistosoma mansoni schistosomula by eosinophils.
Parasite immunology 1993;15(3):181-5.
1992: C A Varley; David W Dunne; J C Havercroft
The influence of adjuvant on humoral responses to glutathione-S-transferase fusion proteins.
Parasite immunology 1992;14(5):557-62.
1992: Anthony Butterworth; David W Dunne; Anthony J C Fulford; K J Thorne; K Gachuhi; J H Ouma; Robert F Sturrock
Human immunity to Schistosoma mansoni: observations on mechanisms, and implications for control.
Immunological investigations 1992;21(5):391-407.
1992: David W Dunne; Anthony Butterworth; Anthony J C Fulford; H Curtis Kariuki; J G Langley; J H Ouma; André Capron; R J Pierce; Robert F Sturrock
Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection.
European journal of immunology 1992;22(6):1483-94.
1992: J G Langley; David W Dunne
Temporal variation in the carbohydrate and peptide surface epitopes in antibody-dependent, eosinophil-mediated killing of Schistosoma mansoni schistosomula.
Parasite immunology 1992;14(2):185-200.
1992: David W Dunne; Anthony Butterworth; Anthony J C Fulford; J H Ouma; Robert F Sturrock
Human IgE responses to Schistosoma mansoni and resistance to reinfection.
Memórias do Instituto Oswaldo Cruz 1992;87 Suppl 4():99-103.
1991: David W Dunne; Frances M Jones; M J Doenhoff
The purification, characterization, serological activity and hepatotoxic properties of two cationic glycoproteins (alpha 1 and omega 1) from Schistosoma mansoni eggs.
Parasitology 1991;103 Pt 2():225-36.
1990: G Mazza; David W Dunne; Anthony Butterworth
Antibody isotype responses to the Schistosoma mansoni schistosomulum in the CBA/N mouse induced by different stages of the parasite life cycle.
Parasite immunology 1990;12(5):529-43.
1990: David W Dunne
Schistosome carbohydrates.
Parasitology today (Personal ed.) 1990;6(2):45-8.
1990: J C Havercroft; M C Huggins; David W Dunne; D W Taylor
Characterisation of Sm20, a 20-kilodalton calcium-binding protein of Schistosoma mansoni.
Molecular and biochemical parasitology 1990;38(2):211-9.
1989: Jamal Khalife; David W Dunne; B A Richardson; G Mazza; K J Thorne; A Capron; Anthony Butterworth
Functional role of human IgG subclasses in eosinophil-mediated killing of schistosomula of Schistosoma mansoni.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4422-7.
1988: Anthony Butterworth; Anthony J C Fulford; David W Dunne; J H Ouma; Robert F Sturrock
Longitudinal studies on human schistosomiasis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1988;321(1207):495-511.
1988: A Butterworth; David W Dunne; Anthony J C Fulford; M Capron; Jamal Khalife; A Capron; Davy K Koech; J Ouma; R Sturrock
Immunity in human schistosomiasis mansoni: cross-reactive IgM and IgG2 anti-carbohydrate antibodies block the expression of immunity.
Biochimie 1988;70(8):1053-63.
1988: J C Havercroft; M C Huggins; Vishvanath Nene; David W Dunne; B A Richardson; D W Taylor; Anthony Butterworth
Cloning of the gene encoding a 50 kilodalton potential surface antigen of Schistosoma mansoni.
Molecular and biochemical parasitology 1988;30(1):83-8.
1988: David W Dunne; G V Hillyer; G Vazquez
Schistosoma mansoni cationic egg antigens (CEF6): immunoserology with oxamniquine-treated patients and involvement of CEF6 in the circumoval precipitin reaction.
The American journal of tropical medicine and hygiene 1988;38(3):508-14.
1988: David W Dunne; A M Grabowska; Anthony J C Fulford; Anthony Butterworth; Robert F Sturrock; Davy K Koech; J H Ouma
Human antibody responses to Schistosoma mansoni: the influence of epitopes shared between different life-cycle stages on the response to the schistosomulum.
European journal of immunology 1988;18(1):123-31.
1987: Anthony Butterworth; R Bensted-Smith; A Capron; M Capron; P R Dalton; David W Dunne; Jean-Marie Grzych; H Curtis Kariuki; Jamal Khalife; Davy K Koech
Immunity in human schistosomiasis mansoni: prevention by blocking antibodies of the expression of immunity in young children.
Parasitology 1987;94 ( Pt 2)():281-300.
1987: David W Dunne; Anthony J C Fulford; Anthony Butterworth; Davy K Koech; J H Ouma
Human antibody responses to Schistosoma mansoni: does antigen directed, isotype restriction result in the production of blocking antibodies?
Memórias do Instituto Oswaldo Cruz 1987;82 Suppl 4():101-4.
1986: Vishvanath Nene; David W Dunne; K S Johnson; D W Taylor; J S Cordingley
Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins.
Molecular and biochemical parasitology 1986;21(2):179-88.
1986: Jamal Khalife; M Capron; A Capron; Jean-Marie Grzych; Anthony Butterworth; David W Dunne; J H Ouma
Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies.
The Journal of experimental medicine 1986;164(5):1626-40.
1986: D W Taylor; J S Cordingley; David W Dunne; K S Johnson; W J Haddow; Carlos E Hormaeche; Vishvanath Nene; Anthony Butterworth
Molecular cloning of schistosome genes.
Parasitology 1986;92 Suppl():S73-81.
1985: Anthony Butterworth; M Capron; J S Cordingley; P R Dalton; David W Dunne; H Curtis Kariuki; Gachuhi Kimani; Davy K Koech; M Mugambi; J H Ouma
Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune responses.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1985;79(3):393-408.
1984: Anthony Butterworth; P R Dalton; David W Dunne; M Mugambi; J H Ouma; B A Richardson; T K Siongok; Robert F Sturrock
Immunity after treatment of human schistosomiasis mansoni. I. Study design, pretreatment observations and the results of treatment.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1984;78(1):108-23.
1983: J S Cordingley; D W Taylor; David W Dunne; Anthony Butterworth
Clone banks of cDNA from the parasite Schistosoma mansoni: isolation of clones containing a potentially immunodiagnostic antigen gene.
Gene 1983;26(1):25-39.