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Maria Luisa Dupuis

Research Profile

Chemicals & Drugs

Physiology

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Roberta Riccioni; Maria Luisa Dupuis; Manuela Bernabei; Eleonora Petrucci; Luca Pasquini; Gualtieri Mariani; Maurizio Cianfriglia; Ugo Testa
The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.
Maurizio Cianfriglia; Alessandra Mallano; Alessandro Ascione; Maria Luisa Dupuis
Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line.
Alessandro Ascione; Maurizio Cianfriglia; Maria Luisa Dupuis; Alessandra Mallano; Andrea Sau; Francesca Pellizzari Tregno; Silvia Pezzola; Anna Maria Caccuri
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.

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All Publications

2010: Roberta Riccioni; Maria Luisa Dupuis; Manuela Bernabei; Eleonora Petrucci; Luca Pasquini; Gualtieri Mariani; Maurizio Cianfriglia; Ugo Testa
The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.
Blood cells, molecules & diseases 2010;45(1):86-92.
2010: Maurizio Cianfriglia; Alessandra Mallano; Alessandro Ascione; Maria Luisa Dupuis
Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line.
International journal of oncology 2010;36(6):1513-20.
2009: Alessandro Ascione; Maurizio Cianfriglia; Maria Luisa Dupuis; Alessandra Mallano; Andrea Sau; Francesca Pellizzari Tregno; Silvia Pezzola; Anna Maria Caccuri
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.
Cancer chemotherapy and pharmacology 2009;64(2):419-24.
2008: Silvia Zamboni; Alessandra Mallano; Michela Flego; Alessandro Ascione; Maria Luisa Dupuis; Mara Gellini; Stefano Barca; Maurizio Cianfriglia
Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast.
International journal of oncology 2008;32(6):1245-51.
2008: Giuseppe Filomeni; Paola Turella; Maria Luisa Dupuis; Olindo Forini; Maria Rosa Ciriolo; Maurizio Cianfriglia; Silvia Pezzola; Giorgio Federici; Anna Maria Caccuri
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.
Molecular cancer therapeutics 2008;7(2):371-9.
2007: Michela Flego; Alessandro Ascione; Silvia Zamboni; Maria Luisa Dupuis; Valentina Imperiale; Maurizio Cianfriglia
Generation of human scFvs antibodies recognizing a prion protein epitope expressed on the surface of human lymphoblastoid cells.
BMC biotechnology 2007;7():38.
2007: Maurizio Cianfriglia; Maria Luisa Dupuis; Agnese Molinari; Antonio Verdoliva ; Roberta Costi; Clementina M Galluzzo; Mauro Andreotti; Andrea Cara; Roberto Di Santo; Lucia Palmisano
HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein.
Retrovirology 2007;4():17.
2006: Paola Turella; Giuseppe Filomeni; Maria Luisa Dupuis; Maria Rosa Ciriolo; Agnese Molinari; Francesca De Maria; Marina Tombesi; Maurizio Cianfriglia; Giorgio Federici; Giorgio Ricci; Anna Maria Caccuri
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
The Journal of biological chemistry 2006;281(33):23725-32.
2006: Ernesto Pavoni; Michela Flego; Maria Luisa Dupuis; Stefano Barca; Fiorella Petronzelli; Anna Maria Anastasi; Valeria D'Alessio; Angela Pelliccia; Paola Vaccaro; Giorgia Monteriù; Alessandro Ascione; Rita De Santis; Franco Felici; Maurizio Cianfriglia; Olga Minenkova
Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein.
BMC cancer 2006;6():41.
2005: Stefania Meschini; Manuela Marra; Maria Condello; Annarica Calcabrini; Elena Federici; Maria Luisa Dupuis; Maurizio Cianfriglia; Giuseppe Arancia
Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells.
International journal of oncology 2005;27(6):1597-603.
2005: Alessandro Ascione; Michela Flego; Silvia Zamboni; Emanuela De Cinti; Maria Luisa Dupuis; Maurizio Cianfriglia
Application of a synthetic phage antibody library (ETH-2) for the isolation of single chain fragment variable (scFv) human antibodies to the pathogenic isoform of the hamster prion protein (HaPrPsc).
Hybridoma (2005) 2005;24(3):127-32.
2004: Alessandro Ascione; Michela Flego; Silvia Zamboni; Emanuela De Cinti; Maria Luisa Dupuis; Maurizio Cianfriglia
Isolation and characterization of the human monoclonal antibodies C10 in single-chain fragment variable (scFv) format to glucose oxidase from Aspergillus niger.
Hybridoma and hybridomics 2004;23(6):380-4.
2004: Ernesto Pavoni; Paola Vaccaro; Andrea Pucci; Giorgia Monteriù; Elisa Beghetto; Stefano Barca; Maria Luisa Dupuis; Adolfo De Pasquale Ceratti; Antonio Lugini; Maurizio Cianfriglia; Enrico Cortesi; Franco Felici; Olga Minenkova
Identification of a panel of tumor-associated antigens from breast carcinoma cell lines, solid tumors and testis cDNA libraries displayed on lambda phage.
BMC cancer 2004;4():78.
2004: Carlo Ramoni; Francesca Spadaro; Bianca Barletta; Maria Luisa Dupuis; Franca Podo
Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts.
Experimental cell research 2004;299(2):370-82.
2004: A Maffeo; Francesca Bellomi; I Solimeo; Federica Bambacioni; Carolina Scagnolari; Francesca De Pisa; Maria Luisa Dupuis; Maurizio Cianfriglia; Guido Antonelli; Ombretta Turriziani
P-glycoprotein expression affects the intracellular concentration and antiviral activity of the protease inhibitor saquinavir in a T cell line.
The new microbiologica 2004;27(2 Suppl 1):119-26.
2003: Maria Luisa Dupuis; Michela Flego; Agnese Molinari; Maurizio Cianfriglia
Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells.
HIV medicine 2003;4(4):338-45.
2003: Maria Luisa Dupuis; Marina Tombesi; Marco Sabatini; Maurizio Cianfriglia
Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM cell line.
Chemotherapy 2003;49(1-2):8-16.
2003: Michela Flego; Vito Mennella; Franca Moretti; Francesca Poloni; Maria Luisa Dupuis; Alessandro Ascione; Stefano Barca; Franco Felici; Maurizio Cianfriglia
Identification by phage display of the linear continuous MRPr1 epitope in the multidrug resistance-associated protein (MRP1).
Biological chemistry 2003;384(1):139-42.
2002: Maurizio Cianfriglia; Carlo Cenciarelli; Stefano Barca; Marina Tombesi; Michela Flego; Maria Luisa Dupuis
Monoclonal antibodies as a tool for structure-function studies of the MDR1-P-glycoprotein.
Current protein & peptide science 2002;3(5):513-30.
2002: Michela Flego; Alessandro Ascione; Alessandro Pini; Vito Mennella; Maria Luisa Dupuis; Giuseppe BENAGIANO; Maurizio Cianfriglia
[Use of phage libraries for the in vitro production of recombinant monoclonal antibodies of predetermined specificity].
Annali dell'Istituto superiore di sanità 2002;38(4):401-10.
2002: Maria Luisa Dupuis; Marina Tombesi; Maurizio Cianfriglia
Modulation of the multidrug resistance (MDR) phenotype in CEM MDR cells simultaneously exposed to anti HIV-1 protease inhibitors (PI's) and cytotoxic drugs.
Annali dell'Istituto superiore di sanità 2002;38(4):387-92.
2000: Maria Teresa Fiorillo; M Maragno; R Butler; Maria Luisa Dupuis; Rosa Sorrentino
CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis.
The Journal of clinical investigation 2000;106(1):47-53.
2000: M R Fizzano; Luisa Valvo; Maria Luisa Dupuis; Vito Mennella; Maurizio Cianfriglia
LC determination of indinavir in biological matrices with electrochemical detection.
Journal of pharmaceutical and biomedical analysis 2000;22(2):307-14.
1999: Patrizia Puddu; Stefano Fais; Francesca Luciani; Giovanni Gherardi; Maria Luisa Dupuis; Giulia Romagnoli; Carlo Ramoni; Maurizio Cianfriglia; Sandra Gessani
Interferon-gamma up-regulates expression and activity of P-glycoprotein in human peripheral blood monocyte-derived macrophages.
Laboratory investigation; a journal of technical methods and pathology 1999;79(10):1299-309.
1998: Maria Teresa Fiorillo; G Greco; M Maragno; I Potolicchio; A Monizio; Maria Luisa Dupuis; Rosa Sorrentino
The naturally occurring polymorphism Asp116-->His116, differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition.
European journal of immunology 1998;28(8):2508-16.
1997: Carlo Ramoni; C Ceracchini; Maria Luisa Dupuis; Carlo Petrini; A Polichetti; Paolo Vecchia
Human natural killer cell-target cell conjugate formation after exposure to extremely low frequency magnetic fields: a cytometric analysis.
European journal of histochemistry : EJH 1997;41 Suppl 2():185-6.
1995: Carlo Ramoni; Maria Luisa Dupuis; Paolo Vecchia; A Polichetti; Carlo Petrini; F Bersani; M Capri; Andrea Cossarizza; Claudio Franceschi; Michele E Grandolfo
Human natural killer cytotoxic activity is not affected by in vitro exposure to 50-Hz sinusoidal magnetic fields.
International journal of radiation biology 1995;68(6):693-705.
1995: Giuseppe Arancia; Agnese Molinari; Pasqualina Crateri; Annarita Stringaro; Carlo Ramoni; Maria Luisa Dupuis; MJ Gomez; Antonella Torosantucci; Antonio Cassone
Noninhibitory binding of human interleukin-2-activated natural killer cells to the germ tube forms of Candida albicans.
Infection and immunity 1995;63(1):280-8.
1991: Maria Luisa Dupuis; Carlo Ramoni; A Yassen; Paola Samoggia; M Tombesi; M Caserta; Maurizio Cianfriglia
The over-expression of P-glycoprotein in K-562 and DAUDI cells, is associated with a high susceptibility to NK and LAK cells.
Journal of biological regulators and homeostatic agents 1991;5(4):137-41.
1991: C Cenciarelli; S J Currier; M C Willingham; F Thiebaut; ursula germann; A V Rutherford; Michael M Gottesman; Stefano Barca; M Tombesi; S Morrone; A Santoni; M Mariani; Carlo Ramoni; Maria Luisa Dupuis; Maurizio Cianfriglia
Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein): determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants.
International journal of cancer. Journal international du cancer 1991;47(4):533-43.
1991: Walter Malorni; Silvia Paradisi; Maria Luisa Dupuis; Carla Fiorentini; Carlo Ramoni
Enhancement of cell-mediated cytotoxicity by Clostridium difficile toxin A: an in vitro study.
Toxicon : official journal of the International Society on Toxinology 1991;29(4-5):417-28.
1990: Carlo Ramoni; Maria Luisa Dupuis; C Cenciarelli; F Ciccolini; Maurizio Cianfriglia
Susceptibility of multidrug-resistant human T-lymphoblastoid CEM cell line to cell-mediated cytolysis.
Annali dell'Istituto superiore di sanità 1990;26(3-4):433-9.