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Andrea Duranti

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Mauro DE Santi; Andrea Duranti; Luca Galluzzi; Mauro Magnani; Giorgio Brandi
The Indole-3-carbinol Cyclic Tetrameric Derivative CTet Synergizes with Cisplatin and Doxorubicin in Triple-negative Breast Cancer Cell Lines.
Giorgio Brandi; Barbara Cervasi; Mauro De Santi; Andrea Duranti; Alessandra Fraternale; Luca Galluzzi; Simone Lucarini; Mirko Paiardini; Maria F Paoletti; Mauro Magnani
Antitumoral Activity of Indole-3-carbinol Cyclic tri- and Tetrameric Derivatives Mixture in Human Breast Cancer Cells: In Vitro and In Vivo Studies.
Oscar Sasso; Glauco Tarozzo; Giorgio Tarzia; Natalia Realini; Angelo Reggiani; Rosalia Bertorelli; Mauro Dionisi; Andrea Duranti; Cataldo Martucci; Luisa Mengatto; Marco Mor; Guillermo Moreno-Sanz; Daniele Piomelli
Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models.

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All Publications

2013: Mauro DE Santi; Andrea Duranti; Luca Galluzzi; Mauro Magnani; Giorgio Brandi
The Indole-3-carbinol Cyclic Tetrameric Derivative CTet Synergizes with Cisplatin and Doxorubicin in Triple-negative Breast Cancer Cell Lines.
Anticancer research 2013;33(5):1867-72.
2013: Giorgio Brandi; Barbara Cervasi; Mauro De Santi; Andrea Duranti; Alessandra Fraternale; Luca Galluzzi; Simone Lucarini; Mirko Paiardini; Maria F Paoletti; Mauro Magnani
Antitumoral Activity of Indole-3-carbinol Cyclic tri- and Tetrameric Derivatives Mixture in Human Breast Cancer Cells: In Vitro and In Vivo Studies.
Anti-cancer agents in medicinal chemistry 2013;13(4):654-62.
2013: Oscar Sasso; Glauco Tarozzo; Giorgio Tarzia; Natalia Realini; Angelo Reggiani; Rosalia Bertorelli; Mauro Dionisi; Andrea Duranti; Cataldo Martucci; Luisa Mengatto; Marco Mor; Guillermo Moreno-Sanz; Daniele Piomelli
Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models.
Pain 2013;154(3):350-60.
2012: Silvia Carloni; Andrea Duranti; Silvia Girelli; Enrique Hilario; Daniele Piomelli; Andrea Tontini; Daniel Alonso-Alconada; Antonia Alvarez; Walter Balduini
Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats.
Pediatric research 2012;72(4):400-6.
2012: Andrea Duranti; Alessandro Fioni; Alessio Lodola; Daniele Piomelli; Silvia Rivara; Claudia Silva; Carlos Solorzano; Giorgio Tarzia; Andrea Tontini; Federica Vacondio; Francesca Antonietti; Marco Mor
N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships.
Journal of medicinal chemistry 2012;55(10):4824-36.
2012: Luca Galluzzi; Nadia Zaffaroni; Giorgio Brandi; Rita Crinelli; Cinzia De Marco; Mauro De Santi; Andrea Duranti; Mauro Magnani
Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines.
PloS one 2012;7(8):e43249.
2011: Federica Vacondio; Caterina Carmi; Jason R Clapper; Andrea Duranti; Alessio Lodola; Daniele Piomelli; Silvia Rivara; Silvano Sanchini; Claudia Silva; Giorgio Tarzia; Andrea Tontini; sha mor
Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.
European journal of medicinal chemistry 2011;46(9):4466-73.
2011: Andrea Cippitelli; Andrea Duranti; Marsida Kallupi; Daniele Piomelli; Fernando Rodrìguez de Fonseca; Gianni Sagratini; Serena Stopponi; Massimo Ubaldi; Giuseppe Astarita; Giovanni Caprioli; Roberto Ciccocioppo
Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.
PloS one 2011;6(11):e28142.
2011: Mauro De Santi; Andrea Duranti; Mirco Fanelli; Alessandra Fraternale; Luca Galluzzi; Simone Lucarini; Giorgio Brandi; Cinzia De Marco; Maria Filomena Paoletti; Nadia Zaffaroni; Mauro Magnani
The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines.
Breast cancer research : BCR 2011;13(2):R33.
2010: Jason R Clapper; Guillermo Moreno-Sanz; Roberto Russo; Ana Guijarro; Federica Vacondio; Andrea Duranti; Andrea Tontini; Silvano Sanchini; Natale R Sciolino; Jessica M Spradley; Andrea G Hohmann; Antonio Calignano; sha mor; Giorgio Tarzia; Daniele Piomelli
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Nature neuroscience 2010;13(10):1265-70.
2010: Alessia Carocci; Alessia Catalano; Angelo Lovece; Giovanni Lentini; Andrea Duranti; Valeria Lucini; Marilou Pannacci; Francesco Scaglione; Carlo Franchini
Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors.
Bioorganic & medicinal chemistry 2010;18(17):6496-511.
2010: Carlos Solorzano; Francesca Antonietti; Andrea Duranti; Andrea Tontini; Silvia Rivara; Alessio Lodola; Federica Vacondio; Giorgio Tarzia; Daniele Piomelli; sha mor
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.
Journal of medicinal chemistry 2010;53(15):5770-81.
2010: Simone Lucarini; Mauro De Santi; Francesca Antonietti; Giorgio Brandi; Giuseppe Diamantini; Alessandra Fraternale; Maria Filomena Paoletti; Andrea Tontini; Mauro Magnani; Andrea Duranti
Synthesis and biological evaluation of a gamma-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b':7,8-b'':10,11-b''']tetraindole (CTet).
Molecules (Basel, Switzerland) 2010;15(6):4085-93.
2009: Carlos Solorzano; Chenggang Zhu; Natalia Battista; Giuseppe Astarita; Alessio Lodola; Silvia Rivara; sha mor; Roberto Russo; Mauro Maccarrone; Francesca Antonietti; Andrea Duranti; Andrea Tontini; Salvatore Cuzzocrea; Giorgio Tarzia; Daniele Piomelli
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20966-71.
2009: Jason R Clapper; Federica Vacondio; Alvin R King; Andrea Duranti; Andrea Tontini; Claudia Silva; Silvano Sanchini; Giorgio Tarzia; sha mor; Daniele Piomelli
A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo.
ChemMedChem 2009;4(9):1505-13.
2009: Federica Vacondio; Claudia Silva; Alessio Lodola; Alessandro Fioni; Silvia Rivara; Andrea Duranti; Andrea Tontini; Silvano Sanchini; Jason R Clapper; Daniele Piomelli; sha mor; Giorgio Tarzia
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.
ChemMedChem 2009;4(9):1495-504.
2009: Jesse LoVerme; Andrea Duranti; Andrea Tontini; Gilberto Spadoni; sha mor; Silvia Rivara; Nephi Stella; Cong Xu; Giorgio Tarzia; Daniele Piomelli
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice.
Bioorganic & medicinal chemistry letters 2009;19(3):639-43.
2009: Francis Bambico; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; Gabriella Gobbi
Endocannabinoids in the treatment of mood disorders: evidence from animal models.
Current pharmaceutical design 2009;15(14):1623-46.
2007: Alvin R King; Andrea Duranti; Andrea Tontini; Silvia Rivara; Anja Rosengarth; Jason R Clapper; Giuseppe Astarita; Jennifer A Geaga; Hartmut Luecke; sha mor; Giorgio Tarzia; Daniele Piomelli
URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.
Chemistry & biology 2007;14(12):1357-65.
2007: Giovanni Valitutti; Andrea Duranti; Alessio Lodola; sha mor; Giovanni Piersanti; Daniele Piomelli; Silvia Rivara; Andrea Tontini; Giorgio Tarzia; Pietro Traldi
Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors.
Journal of mass spectrometry : JMS 2007;42(12):1624-7.
2007: Marco Bortolato; Regina A Mangieri; Jin Fu; Janet H Kim; Oliver Arguello; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress.
Biological psychiatry 2007;62(10):1103-10.
2007: Giorgio Tarzia; Francesca Antonietti; Andrea Duranti; Andrea Tontini; sha mor; Silvia Rivara; Pietro Traldi; Giuseppe Astarita; Alvin King; Jason R Clapper; Daniele Piomelli
Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).
Annali di chimica 2007;97(9):887-94.
2007: Roberto Russo; Jesse LoVerme; Giovanna La Rana; Timothy R Compton; Jeff Parrott; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Antonio Calignano; Daniele Piomelli
The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.
The Journal of pharmacology and experimental therapeutics 2007;322(1):236-42.
2006: Jason R Clapper; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;54(5):341-4.
2006: Giorgio Tarzia; Andrea Duranti; Giuseppe Gatti; Giovanni Piersanti; Andrea Tontini; Silvia Rivara; Alessio Lodola; Pier Vincenzo Plazzi; sha mor; Satish Kathuria; Daniele Piomelli
Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
ChemMedChem 2006;1(1):130-9.
2006: Daniele Piomelli; Giorgio Tarzia; Andrea Duranti; Andrea Tontini; sha mor; Timothy R Compton; Olivier Dasse; Edward P Monaghan; Jeff A Parrott; David Putman
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
CNS drug reviews 2006;12(1):21-38.
2005: Gabriella Gobbi; Francis Bambico; Regina A Mangieri; Marco Bortolato; Patrizia Campolongo; M Solinas; Tommaso Cassano; Maria Grazia Morgese; Guy Debonnel; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; sha mor; Viviana Trezza; S R Goldberg; Vincenzo Cuomo; Daniele Piomelli
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18620-5.
2005: sha mor; Silvia Rivara; Alessio Lodola; Simone Lorenzi; Fabrizio Bordi; Pier Vincenzo Plazzi; Gilberto Spadoni; Annalida Bedini; Andrea Duranti; Andrea Tontini; Giorgio Tarzia
Application of 3D-QSAR in the rational design of receptor ligands and enzyme inhibitors.
Chemistry & biodiversity 2005;2(11):1438-51.
2005: Judit K Makara; sha mor; Darren Fegley; Szilárd I Szabó; Satish Kathuria; Giuseppe Astarita; Andrea Duranti; Andrea Tontini; Giorgio Tarzia; Silvia Rivara; Tamás F Freund; Daniele Piomelli
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.
Nature neuroscience 2005;8(9):1139-41.
2005: Andrea G Hohmann; Richard L Suplita; Nathan M Bolton; Mark H Neely; Darren Fegley; Regina A Mangieri; Jocelyn F Krey; J Michael Walker; Philip V Holmes; Jonathon D Crystal; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
An endocannabinoid mechanism for stress-induced analgesia.
Nature 2005;435(7045):1108-12.
2005: Darren Fegley; Silvana Gaetani; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Daniele Piomelli
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.
The Journal of pharmacology and experimental therapeutics 2005;313(1):352-8.
2004: Elisa Basso; Andrea Duranti; sha mor; Daniele Piomelli; Andrea Tontini; Giorgio Tarzia; Pietro Traldi
Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters.
Journal of mass spectrometry : JMS 2004;39(12):1450-5.
2004: sha mor; Silvia Rivara; Alessio Lodola; Pier Vincenzo Plazzi; Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Giovanni Piersanti; Satish Kathuria; Daniele Piomelli
Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2004;47(21):4998-5008.
2003: Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Gilberto Spadoni; sha mor; Silvia Rivara; Pier Vincenzo Plazzi; Satish Kathuria; Daniele Piomelli
Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists.
Bioorganic & medicinal chemistry 2003;11(18):3965-73.
2003: Giorgio Tarzia; Andrea Duranti; Andrea Tontini; Giovanni Piersanti; sha mor; Silvia Rivara; Pier Vincenzo Plazzi; Chris Park; Satish Kathuria; Daniele Piomelli
Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.
Journal of medicinal chemistry 2003;46(12):2352-60.
2003: Satish Kathuria; Silvana Gaetani; Darren Fegley; Fernando Valiño; Andrea Duranti; Andrea Tontini; sha mor; Giorgio Tarzia; Giovanna La Rana; Antonio Calignano; Arcangela Giustino; Maria Tattoli; Maura Palmery; Vincenzo Cuomo; Daniele Piomelli
Modulation of anxiety through blockade of anandamide hydrolysis.
Nature medicine 2003;9(1):76-81.
2000: Andrea Duranti; Carlo Franchini; Giovanni Lentini; Fulvio Loiodice; Vincenzo Tortorella; A De Luca; Sabata Pierno; Diana Conte Camerino
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels.
European journal of medicinal chemistry 2000;35(1):147-56.
1997: Annamaria De Luca; Fedele Natuzzi; G Falcone; Andrea Duranti; Giovanni Lentini; Carlo Franchini; Vincenzo Tortorella; Diana Conte Camerino
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(6):777-87.
1997: Annamaria De Luca; Sabata Pierno; Fedele Natuzzi; Carlo Franchini; Andrea Duranti; Giovanni Lentini; Vincenzo Tortorella; Harald Jockusch; Diana Conte Camerino
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.
The Journal of pharmacology and experimental therapeutics 1997;282(1):93-100.