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Donald Durden

Research Profile

Physiology

Signal Transduction

Chemicals & Drugs

Phenomena

Phosphorylation

Living Beings

Mouse

Anatomy

Concepts & Ideas

Disorders

Neovascularization, Pathologic

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Pradip De; Nandini Dey; P Leif Bergsagel; Joseph R Garlich; Zhi Hua Li; Daruka Mahadevan; Milan T Makale; Breanne Terakedis; Suzanne Trudel; Donald L Durden
An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.
Susan K Peirce; Chengyu Prince; Todd Cooper; Anindya Dasgupta; Harry W Findley; Donald L Durden
The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention.
Tuba Ozbay; Donald L Durden; Tongrui Liu; Ruth M O'Regan; Rita Nahta
In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.

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All Publications

2013: Pradip De; Nandini Dey; P Leif Bergsagel; Joseph R Garlich; Zhi Hua Li; Daruka Mahadevan; Milan T Makale; Breanne Terakedis; Suzanne Trudel; Donald L Durden
An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.
Cancer chemotherapy and pharmacology 2013;71(4):867-81.
2011: Susan K Peirce; Chengyu Prince; Todd Cooper; Anindya Dasgupta; Harry W Findley; Donald L Durden
The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention.
Cancer chemotherapy and pharmacology 2011;68(2):325-35.
2010: Tuba Ozbay; Donald L Durden; Tongrui Liu; Ruth M O'Regan; Rita Nahta
In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.
Cancer chemotherapy and pharmacology 2010;65(4):697-706.
2010: Robert Craig Castellino; Benjamin G Barwick; Matthew Schniederjan; Meghan C Buss; Oren Josh Becher; Dolares Hambardzumyan; Tobey J MacDonald; Daniel J Brat; Donald L Durden
Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
PloS one 2010;5(5):e10849.
2009: Lubing Gu; Ningxi Zhu; Hongying Zhang; Donald L Durden; Yue Feng; Muxiang Zhou
Regulation of XIAP translation and induction by MDM2 following irradiation.
Cancer cell 2009;15(5):363-75.
2009: Yuan Rong; Vladimir E Belozerov; Carol Tucker-Burden; Gang Chen; Donald L Durden; Jeffrey J Olson; Erwin Van Meir; Nigel Mackman; Daniel J Brat
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
Cancer research 2009;69(6):2540-9.
2009: Pradip De; Qiong Peng; Dmitry O Traktuev; Dmitry O Traktuevc; Weiming Li; Mervin C Yoder; Keith March; Donald L Durden
Expression of RAC2 in endothelial cells is required for the postnatal neovascular response.
Experimental cell research 2009;315(2):248-63.
2009: Hal E Crosswell; Anindya Dasgupta; Carlos S Alvarado; Tanya Watt; James G Christensen; Pradip De; Donald L Durden; Harry W Findley
PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells.
BMC cancer 2009;9():411.
2009: Robert Craig Castellino; C R Muh; Donald L Durden
PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis.
Current pharmaceutical design 2009;15(4):380-8.
2008: Nandini Dey; Hal E Crosswell; Pradip De; Ramon Parsons; Qiong Peng; Jing Dong Su; Donald L Durden
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
Cancer research 2008;68(6):1862-71.
2008: Joseph R Garlich; Pradip De; Nandini Dey; Jing Dong Su; Xiaodong Peng; Antoinette Miller; Ravoori Murali; Yiling Lu; Gordon B Mills; Vikas Kundra; H-K Shu; Qiong Peng; Donald L Durden
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.
Cancer research 2008;68(1):206-15.
2007: Yu Li; Jingliang Yan; Pradip De; Hua-Chen Chang; Akira Yamauchi; Kent W Christopherson; Nivanka C Paranavitana; Xiaodong Peng; Chaekyun Kim; Veerendra Munugalavadla; Veerendra Munugulavadla; Reuben Kapur; Hanying Chen; Weinian Shou; James C Stone; Mark H Kaplan; Mary C Dinauer; Donald L Durden; Lawrence A Quilliam
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(12):8322-31.
2007: Robert Craig Castellino; Donald L Durden
Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors.
Nature clinical practice. Neurology 2007;3(12):682-93.
2007: Gabriela D. Denning; B Jean-Joseph; C Prince; Donald L Durden; Peter K Vogt
A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.
Oncogene 2007;26(27):3930-40.
2007: Nandini Dey; Pradip De; Mu Wang; Hongying Zhang; Erika A Dobrota; Kent A Robertson; Donald L Durden
CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation.
Molecular and cellular biology 2007;27(11):4179-97.
2006: Rachel B Reinert; L Morgan Oberle; Sheree A Wek; Piyawan Bunpo; Xue Ping Wang; Izolda Mileva; Leslie O Goodwin; Carla J Aldrich; Donald L Durden; Margaret A McNurlan; Ronald C Wek; Tracy G Anthony
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
The Journal of biological chemistry 2006;281(42):31222-33.
2006: Yuan Rong; Fang Hu; Ruopan Huang; Nigel Mackman; Jonathan M Horowitz; Randy L Jensen; Donald L Durden; Erwin Van Meir; Daniel J Brat
Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.
Cancer research 2006;66(14):7067-74.
2006: Yuan Rong; Donald L Durden; Erwin Van Meir; Daniel J Brat
'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.
Journal of neuropathology and experimental neurology 2006;65(6):529-39.
2005: Nandini Dey; Brian Howell; Pradip De; Donald L Durden
CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity.
Experimental cell research 2005;307(1):1-14.
2005: Yuan Rong; Dawn E Post; Russell O Pieper; Donald L Durden; Erwin Van Meir; Daniel J Brat
PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.
Cancer research 2005;65(4):1406-13.
2005: Kyung D Moon; Carol Beth Post; Donald L Durden; Qing Zhou; Pradip De; Marietta L Harrison; Robert L Geahlen
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.
The Journal of biological chemistry 2005;280(2):1543-51.
2003: De Pradip; Xiaodong Peng; Donald L Durden
Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase.
The Journal of biological chemistry 2003;278(43):41661-9.
2003: Jing Dong Su; Lindsey D Mayo; David B Donner; Donald L Durden
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
Cancer research 2003;63(13):3585-92.
2002: Anat Erdreich-Epstein; Linda B Tran; Nina N Bowman; Hongtao Wang; Myles C Cabot; Donald L Durden; Jitka Vlckova; Charles Patrick Reynolds; Monique F Stins; Susan Groshen; Melissa Millard
Ceramide signaling in fenretinide-induced endothelial cell apoptosis.
The Journal of biological chemistry 2002;277(51):49531-7.
2002: Anita M Kant; Pradip De; Xiaodong Peng; Taolin Yi; David J Rawlings; Jong Suk Kim; Donald L Durden
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood 2002;100(5):1852-9.
2002: Lindsey D Mayo; Jack E Dixon; Donald L Durden; Nicholas K Tonks; David B Donner
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
The Journal of biological chemistry 2002;277(7):5484-9.
2002: Jong Suk Kim; Xiaodong Peng; Pradip De; Robert L Geahlen; Donald L Durden
PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac.
Blood 2002;99(2):694-7.
2001: Andreas Reiff; M Zastrow; B C Sun; Syuji Takei; H Mitsuhada; Bram Bernstein; Donald L Durden
Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase.
Clinical and experimental rheumatology 2001;19(6):639-46.
2001: C Isogai; Walter E Laug; Hiroyuki Shimada; P J Declerck; Monique F Stins; Donald L Durden; Anat Erdreich-Epstein; Yves A DeClerck
Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin.
Cancer research 2001;61(14):5587-94.
2001: S Wen; JP Stolarov; Michael P Myers; Jing Dong Su; Michael Wigler; Nicholas K Tonks; Donald L Durden
PTEN controls tumor-induced angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4622-7.
2000: Anat Erdreich-Epstein; Hiroyuki Shimada; Susan Groshen; M Liu; Leonid S Metelitsa; Kwang S Kim; Monique F Stins; Robert C Seeger; Donald L Durden
Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide.
Cancer research 2000;60(3):712-21.
1999: RK Park; Anat Erdreich-Epstein; M Liu; KD Izadi; Donald L Durden
High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6023-34.
1999: RK Park; KD Izadi; Y M Deo; Donald L Durden
Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.
Blood 1999;94(6):2112-20.
1999: Anat Erdreich-Epstein; M Liu; Anita M Kant; KD Izadi; Jan A Nolta; Donald L Durden
Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.
Journal of leukocyte biology 1999;65(4):523-34.
1998: KD Izadi; Anat Erdreich-Epstein; Y Liu; Donald L Durden
Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.
Experimental cell research 1998;245(2):330-42.
1998: W T Kyono; Ron de Jong; RK Park; Yi Liu; Nora Heisterkamp; John Groffen; Donald L Durden
Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5555-63.
1998: J Chu; Yi Liu; G A Koretzky; Donald L Durden
SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.
Blood 1998;92(5):1697-706.
1998: RK Park; W T Kyono; Yi Liu; Donald L Durden
CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):5018-27.
1997: Anat Erdreich-Epstein; M Liu; Yi Liu; Donald L Durden
Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling.
Experimental cell research 1997;237(2):288-95.
1997: N Taylor; Thomas Jahn; S Smith; T Lamkin; L Uribe; Y Liu; Donald L Durden; Kenneth I Weinberg
Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc gamma RI stimulation.
Blood 1997;89(2):388-96.
1996: RK Park; Yi Liu; Donald L Durden
A role for Shc, Grb2, and Raf-1 in FcgammaRI signal relay.
The Journal of biological chemistry 1996;271(23):13342-8.
1995: M Arditi; J Zhou; M Torres; Donald L Durden; Monique F Stins; Kwang S Kim
Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD14-dependent manner. Role of protein tyrosine phosphorylation in lipopolysaccharide-induced stimulation of endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3994-4003.
1995: Donald L Durden; H M Kim; B Calore; Yi Liu
The Fc gamma RI receptor signals through the activation of hck and MAP kinase.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):4039-47.
1994: Donald L Durden; Y B Liu
Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling.
Blood 1994;84(7):2102-8.
1994: Donald L Durden; H Rosen; J A Cooper
Serine/threonine phosphorylation of the gamma-subunit after activation of the high-affinity Fc receptor for immunoglobulin G.
The Biochemical journal 1994;299 ( Pt 2)():569-77.
1994: Donald L Durden; H Rosen; B R Michel; J A Cooper
Protein tyrosine phosphatase inhibitors block myeloid signal transduction through the Fc gamma RI receptor.
Experimental cell research 1994;211(1):150-62.
1991: Andrius Kazlauskas; Donald L Durden; Jonathan A Cooper
Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.
Cell regulation 1991;2(6):413-25.
1983: Donald L Durden; A M Salazar; J A Distasio
Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases.
Cancer research 1983;43(4):1602-5.
1982: J A Distasio; A M Salazar; Mehrdad Nadji; Donald L Durden
Glutaminase-free asparaginase from vibrio succinogenes: an antilymphoma enzyme lacking hepatotoxicity.
International journal of cancer. Journal international du cancer 1982;30(3):343-7.
1982: J A Distasio; Donald L Durden; R D Paul; Mehrdad Nadji
Alteration in spleen lymphoid populations associated with specific amino acid depletion during L-asparaginase treatment.
Cancer research 1982;42(1):252-8.
1981: Donald L Durden; J A Distasio
Characterization of the effects of asparaginase from Escherichia coli and a glutaminase-free asparaginase from Vibrio succinogenes on specific ell-mediated cytotoxicity.
International journal of cancer. Journal international du cancer 1981;27(1):59-65.
1980: Donald L Durden; J A Distasio
Comparison of the immunosuppressive effects of asparaginases from Escherichia coli and Vibrio succinogenes.
Cancer research 1980;40(4):1125-9.
1979: V Charyulu; M M Sigel; Donald L Durden; Diana M Lopez
Mouse mammary tumor virus (MMTV) antigen(s) are present on B lymphocytes of BALB/c mice.
International journal of cancer. Journal international du cancer 1979;24(6):813-8.