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Heather Durham

Research Profile

Living Beings

Anatomy

Disorders

Amyotrophic Lateral Sclerosis

Chemicals & Drugs

Physiology

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Publications

TOP 3
Edor Kabashi; Michael J Strong; Jeffrey N Agar; Heather D Durham
Impaired proteasome function in sporadic amyotrophic lateral sclerosis.
benoit Gentil; Jean-Pierre Julien; Sandra Minotti; Robert H Baloh; Madeleine Beange; Heather D Durham
Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease.
Miranda L Tradewell; Laura A Cooper; Sandra Minotti; Heather D Durham
Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention.

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All Publications

2012: Edor Kabashi; Michael J Strong; Jeffrey N Agar; Heather D Durham
Impaired proteasome function in sporadic amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2012;13(4):367-71.
2012: benoit Gentil; Jean-Pierre Julien; Sandra Minotti; Robert H Baloh; Madeleine Beange; Heather D Durham
Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1194-203.
2011: Miranda L Tradewell; Laura A Cooper; Sandra Minotti; Heather D Durham
Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention.
Neurobiology of disease 2011;42(3):265-75.
2010: Miranda L Tradewell; Heather D Durham
Calpastatin reduces toxicity of SOD1G93A in a culture model of amyotrophic lateral sclerosis.
Neuroreport 2010;21(15):976-9.
2009: Miranda L Tradewell; Heather D Durham; Walter E Mushynski; benoit Gentil
Mitochondrial and axonal abnormalities precede disruption of the neurofilament network in a model of charcot-marie-tooth disease type 2E and are prevented by heat shock proteins in a mutant-specific fashion.
Journal of neuropathology and experimental neurology 2009;68(6):642-52.
2009: Cara L Ryan; David C Baranowski; Babykumari P Chitramuthu; Suneil Malik; Zhi Li; Mingju Cao; Sandra Minotti; Heather D Durham; Denis George Kay; Christopher Shaw; Hugh P J Bennett; Andrew Bateman
Progranulin is expressed within motor neurons and promotes neuronal cell survival.
BMC neuroscience 2009;10():130.
2008: Edor Kabashi; Jeffrey N Agar; Yu Hong; David M Taylor; Sandra Minotti; Denise A Figlewicz; Heather D Durham
Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2008;105(6):2353-66.
2008: Marie Gingras; Marie-Michèle Beaulieu; Vicky Gagnon; Heather D Durham; François Berthod
In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model.
Glia 2008;56(3):354-64.
2007: Marie Gingras; Vicky Gagnon; Sandra Minotti; Heather D Durham; François Berthod
Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord.
Journal of neuroscience methods 2007;163(1):111-8.
2007: David M Taylor; Bernard F Gibbs; Edor Kabashi; Sandra Minotti; Heather D Durham; Jeffrey N Agar
Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis.
The Journal of biological chemistry 2007;282(22):16329-35.
2007: David M Taylor; Miranda L Tradewell; Sandra Minotti; Heather D Durham
Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.
Cell stress & chaperones 2007;12(2):151-62.
2007: David M Taylor; Paul De Koninck; Sandra Minotti; Heather D Durham
Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells.
Molecular and cellular neurosciences 2007;34(1):20-33.
2006: Zarah Batulan; David M Taylor; Rebecca Aarons; Sandra Minotti; Mohammad M Doroudchi; Josephine Nalbantoglu; Heather D Durham
Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis.
Neurobiology of disease 2006;24(2):213-25.
2006: Edor Kabashi; Heather D Durham
Failure of protein quality control in amyotrophic lateral sclerosis.
Biochimica et biophysica acta 2006;1762(11-12):1038-50.
2005: David M Taylor; Edor Kabashi; Jeffrey N Agar; Sandra Minotti; Heather D Durham
Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts.
Cell stress & chaperones 2005;10(3):230-41.
2005: Zarah Batulan; Josephine Nalbantoglu; Heather D Durham
Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells.
Cell stress & chaperones 2005;10(3):185-96.
2004: David M Taylor; Sandra Minotti; Jeffrey N Agar; Heather D Durham
Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity.
Neurotoxicology 2004;25(5):779-92.
2004: Edor Kabashi; Jeffrey N Agar; David M Taylor; Sandra Minotti; Heather D Durham
Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis.
Journal of neurochemistry 2004;89(6):1325-35.
2003: Jeff Agar; Heather D Durham
Relevance of oxidative injury in the pathogenesis of motor neuron diseases.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2003;4(4):232-42.
2003: Marie Gingras; Julie Bergeron; Julien Déry; Heather D Durham; François Berthod
In vitro development of a tissue-engineered model of peripheral nerve regeneration to study neurite growth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2124-6.
2003: Zarah Batulan; Gayle A Shinder; Sandra Minotti; Bei Ping He; Mohammad M Doroudchi; Josephine Nalbantoglu; Michael J Strong; Heather D Durham
High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5789-98.
2003: Janice Robertson; Mohammad M Doroudchi; Minh Dang Nguyen; Heather D Durham; Michael J Strong; Gerry Shaw; Jean-Pierre Julien; Walter E Mushynski
A neurotoxic peripherin splice variant in a mouse model of ALS.
The Journal of cell biology 2003;160(6):939-49.
2002: Elizabeth Kriscenski-Perry; Heather D Durham; Shey-Shing Sheu; Denise A Figlewicz
Synergistic effects of low level stressors in an oxidative damage model of spinal motor neuron degeneration.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2002;3(3):151-7.
2001: Janice Robertson; Jean-Martin Beaulieu; Mohammad M Doroudchi; Heather D Durham; Jean-Pierre Julien; Walter E Mushynski
Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha.
The Journal of cell biology 2001;155(2):217-26.
2001: Mohammad M Doroudchi; Sandra Minotti; Denise A Figlewicz; Heather D Durham
Nitrotyrosination contributes minimally to toxicity of mutant SOD1 associated with ALS.
Neuroreport 2001;12(6):1239-43.
2001: G A Shinder; M C Lacourse; Sandra Minotti; Heather D Durham
Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis.
The Journal of biological chemistry 2001;276(16):12791-6.
1999: Benoit I Giasson; Wendy Bruening; Heather D Durham; Walter E Mushynski
Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells.
Journal of neurochemistry 1999;72(3):1081-7.
1999: Wendy Bruening; J Roy; Benoit I Giasson; Denise A Figlewicz; Walter E Mushynski; Heather D Durham
Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis.
Journal of neurochemistry 1999;72(2):693-9.
1998: J Roy; Sandra Minotti; L Dong; Denise A Figlewicz; Heather D Durham
Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9673-84.
1998: Wendy Bruening; Benoit I Giasson; Walter E Mushynski; Heather D Durham
Activation of stress-activated MAP protein kinases up-regulates expression of transgenes driven by the cytomegalovirus immediate/early promoter.
Nucleic acids research 1998;26(2):486-9.
1997: Mohammad M Doroudchi; Heather D Durham
Activation of NMDA receptors and Ca2+/calmodulin-dependent protein kinase participate in phosphorylation of neurofilaments induced by protein kinase C.
Journal of neuroscience research 1997;50(4):514-21.
1997: Heather D Durham; MA Alonso-Vanegas; Abbas F Sadikot; L Zhu; H Lochmüller; B Massie; Josephine Nalbantoglu; George Karpati
The immunosuppressant FK506 prolongs transgene expression in brain following adenovirus-mediated gene transfer.
Neuroreport 1997;8(9-10):2111-5.
1997: Heather D Durham; J Roy; L Dong; Denise A Figlewicz
Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS.
Journal of neuropathology and experimental neurology 1997;56(5):523-30.
1996: Heather D Durham; Hanns Lochmüller; Agnes Jani; Gyula Acsadi; Bernard Massie; George Karpati
Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue.
Experimental neurology 1996;140(1):14-20.
1996: Heather D Durham; S Minotti; E Caporicci; S Chakrabarti; J C Panisset
Sensitivity of platelet microtubules to disassembly by methylmercury.
Journal of toxicology and environmental health 1996;48(1):57-69.
1996: George Karpati; Hanns Lochmüller; Josephine Nalbantoglu; Heather D Durham
The principles of gene therapy for the nervous system.
Trends in neurosciences 1996;19(2):49-54.
1996: M M Doroudchi; Heather D Durham
Activation of protein kinase C induces neurofilament fragmentation, hyperphosphorylation of perikaryal neurofilaments and proximal dendritic swellings in cultured motor neurons.
Journal of neuropathology and experimental neurology 1996;55(2):246-56.
1995: Heather D Durham; C O'Brien; Josephine Nalbantoglu; Denise A Figlewicz
Use of tissue culture models to study environmental-genetic interactions relevant to neurodegenerative diseases.
Clinical and experimental pharmacology & physiology 1995;22(5):366-7.
1995: J Kohn; S Minotti; Heather D Durham
Assessment of the neurotoxicity of styrene, styrene oxide, and styrene glycol in primary cultures of motor and sensory neurons.
Toxicology letters 1995;75(1-3):29-37.
1994: Heather D Durham; S Minotti; NP Dooley; Josephine Nalbantoglu
Expression of the intermediate filament-associated protein related to beta-amyloid precursor protein is developmentally regulated in cultured cells.
Journal of neuroscience research 1994;38(6):629-39.
1993: J Kohn; Heather D Durham
S9 liver fraction is cytotoxic to neurons in dissociated culture.
Neurotoxicology 1993;14(4):381-6.
1993: Heather D Durham; S Dahrouge; Neil R Cashman
Evaluation of the spinal cord neuron X neuroblastoma hybrid cell line NSC-34 as a model for neurotoxicity testing.
Neurotoxicology 1993;14(4):387-95.
1992: NP Dooley; S Gauthier; Heather D Durham
Antibody to beta-amyloid precursor protein recognizes an intermediate filament-associated protein in Alzheimer's and control fibroblasts.
Journal of neuroscience research 1992;33(1):60-7.
1992: Neil R Cashman; Heather D Durham; J K Blusztajn; K Oda; Takeshi Tabira; I T Shaw; S Dahrouge; J P Antel
Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons.
Developmental dynamics : an official publication of the American Association of Anatomists 1992;194(3):209-21.
1992: Heather D Durham
An antibody against hyperphosphorylated neurofilament proteins collapses the neurofilament network in motor neurons but not in dorsal root ganglion cells.
Journal of neuropathology and experimental neurology 1992;51(3):287-97.
1989: Heather D Durham; I Salera; S Dahrouge
Evidence that formation of an intermediate filament-protein complex plays a primary role in aggregation of neurofilaments, glial fibrillary acidic protein (GFAP)-filaments and vimentin-filaments by 2,5-hexanedione.
Journal of neuropathology and experimental neurology 1989;48(2):197-211.
1988: Heather D Durham
Aggregation of intermediate filaments by 2,5-hexanedione: comparison of effects on neurofilaments, GFAP-filaments and vimentin-filaments in dissociated cultures of mouse spinal cord-dorsal root ganglia.
Journal of neuropathology and experimental neurology 1988;47(4):432-42.
1988: Heather D Durham; S D Peña; D J Ecobichon
Hexahydrocarbon effects on intermediate filament organization in human fibroblasts.
Muscle & nerve 1988;11(2):160-5.
1988: George Karpati; S Carpenter; Heather D Durham
A hypothesis for the pathogenesis of amyotrophic lateral sclerosis.
Revue neurologique 1988;144(11):672-5.
1986: Heather D Durham; D J Ecobichon
An assessment of the neurotoxic potential of fenitrothion in the hen.
Toxicology 1986;41(3):319-32.
1984: Heather D Durham; D J Ecobichon
The function of motor nerves innervating slow tonic skeletal muscle in hens with delayed neuropathy induced by tri-o-tolyl phosphate.
Canadian journal of physiology and pharmacology 1984;62(10):1268-73.
1982: Heather D Durham; A M Comeau; P H Cameron; D J Ecobichon
Subacute toxicity in rats of orally administered fenitrothion alone and in a selected formulation.
Toxicology and applied pharmacology 1982;62(3):455-64.
1982: C Breckenridge; M Pesant; Heather D Durham; D J Ecobichon
A 30-day toxicity study of inhaled fenitrothion in the albino rat.
Toxicology and applied pharmacology 1982;62(1):32-43.