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Ginger Dutschman

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Dongyuan Piao; Adrian S Ray; Fei You; David J Austin; Aravind Basavapathruni; Guangxiu Dai; Ginger E Dutschman; Joy Y Feng; Wolfgang Hinz; Pinar Iyidogan; Eisuke Murakami; Kathlyn A Parker; Karen S Anderson
Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.
Lun K Tsou; Chin-Ho Chen; Yung-Chi Cheng; Ginger E Dutschman; Andrew D Hamilton
Blocking HIV-1 entry by a gp120 surface binding inhibitor.
Wei Zhang; Edward Chu; Ginger E Dutschman; Elizabeth Gullen; Elijah Paintsil; Shenglan Tan; Yung-Chi Cheng
Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique.

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2013: Dongyuan Piao; Adrian S Ray; Fei You; David J Austin; Aravind Basavapathruni; Guangxiu Dai; Ginger E Dutschman; Joy Y Feng; Wolfgang Hinz; Pinar Iyidogan; Eisuke Murakami; Kathlyn A Parker; Karen S Anderson
Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.
Bioorganic & medicinal chemistry letters 2013;23(5):1511-8.
2012: Lun K Tsou; Chin-Ho Chen; Yung-Chi Cheng; Ginger E Dutschman; Andrew D Hamilton
Blocking HIV-1 entry by a gp120 surface binding inhibitor.
Bioorganic & medicinal chemistry letters 2012;22(9):3358-61.
2011: Wei Zhang; Edward Chu; Ginger E Dutschman; Elizabeth Gullen; Elijah Paintsil; Shenglan Tan; Yung-Chi Cheng
Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique.
Biochemical pharmacology 2011;82(4):411-7.
2011: Wei Zhang; Ginger E Dutschman; Xin Li; Yung-Chi Cheng
Quantitation of paclitaxel and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(22):2018-22.
2011: Francesca Esposito; Giovanni Floris; Tatyana Kharlamova; Patrick Martk; Yung-Chi Cheng; Angela Corona; Simona Distinto; Ginger E Dutschman; Luca Zinzula; Enzo Tramontano
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.
The FEBS journal 2011;278(9):1444-57.
2011: Elijah Paintsil; Ginger E Dutschman; Rong Hu; Susan P Grill; Chuan-Jen Wang; Wing Lam; Fang-Yong Li; Musie Ghebremichael; Veronika Northrup; Yung-Chi Cheng
Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites.
Antimicrobial agents and chemotherapy 2011;55(2):895-903.
2010: Wei Zhang; Muhammad W Saif; Ginger E Dutschman; Xin Li; Wing Lam; Scott Bussom; Zaoli Jiang; Min Ye; Edward Chu; Yung-Chi Cheng
Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
Journal of chromatography. A 2010;1217(37):5785-93.
2010: John Hines; Rong Ju; Ginger E Dutschman; Yung-Chi Cheng; Craig M Crews
Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides.
The Journal of pharmacology and experimental therapeutics 2010;334(3):729-38.
2010: Lun K Tsou; Ginger E Dutschman; Elizabeth Gullen; Maria Telpoukhovskaia; Yung-Chi Cheng; Andrew D Hamilton
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.
Bioorganic & medicinal chemistry letters 2010;20(7):2137-9.
2010: Yao Cheng; Lun K Tsou; Jianfeng Cai; Toshihiro Aya; Ginger E Dutschman; Elizabeth Gullen; Susan P Grill; Annie Pei-Chun Chen; Brett D Lindenbach; Andrew D Hamilton; Yung-Chi Cheng
A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.
Antimicrobial agents and chemotherapy 2010;54(1):197-206.
2009: Guangwei Yang; Elijah Paintsil; Ginger E Dutschman; Susan P Grill; Chuan-Jen Wang; Jimin Wang; Hiromichi Tanaka; Takayuki Hamasaki; Masanori Baba; Yung-Chi Cheng
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Antimicrobial agents and chemotherapy 2009;53(11):4640-6.
2009: Wei Zhang; Ginger E Dutschman; Xin Li; Min Ye; Yung-Chi Cheng
Quantitation of Irinotecan and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometric.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(27):3038-44.
2009: Kazuhiro Haraguchi; Hisashi Shimada; Genta Akutsu; Keigo Kimura; Hiromichi Tanaka; Takayuki Hamasaki; Masanori Baba; Elizabeth A Gullen; Ginger E Dutschman; Yung-Chi Cheng; Jan Balzarini
Synthesis and anti-HIV activity of 4'-C-ethynyl-2'-deoxy-4'-thio-nucleosides.
Nucleic acids symposium series (2004) 2009;(53):97-8.
2009: Elijah Paintsil; Susan P Grill; Ginger E Dutschman; Yung-Chi Cheng
Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture.
AIDS research and therapy 2009;6():5.
2008: Guangwei Yang; Jimin Wang; Yao Cheng; Ginger E Dutschman; Hiromichi Tanaka; Masanori Baba; Yung-Chi Cheng
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate.
Antimicrobial agents and chemotherapy 2008;52(6):2035-42.
2008: Kazuhiro Haraguchi; Hisashi Shimada; Hiromichi Tanaka; Takayuki Hamasaki; Masanori Baba; Elizabeth A Gullen; Ginger E Dutschman; Yung-Chi Cheng
Synthesis and anti-HIV activity of 4'-substituted 4'-thiothymidines: a new entry based on nucleophilic substitution of the 4'-acetoxy group.
Journal of medicinal chemistry 2008;51(6):1885-93.
2007: Elijah Paintsil; Ginger E Dutschman; Rong Hu; Susan P Grill; Wing Lam; Masanori Baba; Hiromichi Tanaka; Yung-Chi Cheng
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
Antimicrobial agents and chemotherapy 2007;51(11):3870-9.
2007: Chih-Hung Hsu; Rong Hu; Ginger E Dutschman; Guangwei Yang; Preethi Krishnan; Hiromichi Tanaka; Masanori Baba; Yung-Chi Cheng
Comparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs.
Antimicrobial agents and chemotherapy 2007;51(5):1687-93.
2007: Guangwei Yang; Ginger E Dutschman; Chuan-Jen Wang; Hiromichi Tanaka; Masanori Baba; Karen S Anderson; Yung-Chi Cheng
Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT.
Antiviral research 2007;73(3):185-91.
2006: Hiroki Kumamoto; Sayoko Onuma; Hiromichi Tanaka; Ginger E Dutschman; Yung-Chi Cheng
3'-Carbon-substituted pyrimidine nucleosides having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy structure: synthesis and antiviral evaluation.
Antiviral chemistry & chemotherapy 2006;17(4):225-34.
2005: Rong Hu; Ling Li; Bart Degrève; Ginger E Dutschman; Wing Lam; Yung-Chi Cheng
Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.
Antimicrobial agents and chemotherapy 2005;49(5):2044-9.
2005: Adrian S Ray; Brenda I Hernandez-Santiago; Judy S Mathew; Eisuke Murakami; Carey Bozeman Clark; Meng-Yu Xie; Ginger E Dutschman; Elizabeth Gullen; Zhenjun Yang; Selwyn Hurwitz; Yung-Chi Cheng; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi; Karen S Anderson
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.
Antimicrobial agents and chemotherapy 2005;49(5):1994-2001.
2005: Chih-Hung Hsu; Jieh-Yuan Liou; Ginger E Dutschman; Yung-Chi Cheng
Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.
Molecular pharmacology 2005;67(3):806-14.
2005: Hosup Yeo; Ying Li; Lei Fu; Ju-Liang Zhu; Elizabeth Gullen; Ginger E Dutschman; Yashang Lee; Raymond Chung; Eng-Shang Huang; David J Austin; Yung-Chi Cheng
Synthesis and antiviral activity of helioxanthin analogues.
Journal of medicinal chemistry 2005;48(2):534-46.
2005: Kazuhiro Haraguchi; Shingo Takeda; Masanori Sumino; Hiromichi Tanaka; Ginger E Dutschman; Yung-Chi Cheng; Takao Nitanda; Masanori Baba
A new approach to the synthesis of 4'-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2', 3'-didehydro-3'-deoxy-4'-ethynylthymidine.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):343-7.
2005: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of 2',3'-didehydro-2',3'-dideoxy-9-deazaguanosine, a monophosphate prodrug and two analogues, 2',3'-dideoxy-9-deazaguanosine and 2',3'-didehydro-2',3'-dideoxy-9-deazainosine.
Nucleosides, nucleotides & nucleic acids 2005;24(2):135-45.
2005: Hiroki Kumamoto; Kazuhiro Haraguchi; Hiromichi Tanaka; Takao Nitanda; Masanori Baba; Ginger E Dutschman; Yung-Chi Cheng; Keisuke Kato
Synthesis of (+/-)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T).
Nucleosides, nucleotides & nucleic acids 2005;24(2):73-83.
2004: Tracy E Kim; Shin-Young Park; Chih-Hung Hsu; Ginger E Dutschman; Yung-Chi Cheng
Synergistic antitumor activity of troxacitabine and camptothecin in selected human cancer cell lines.
Molecular pharmacology 2004;66(2):285-92.
2004: Ginger E Dutschman; Susan P Grill; Elizabeth Gullen; Kazuhiro Haraguchi; Shingo Takeda; Hiromichi Tanaka; Masanori Baba; Yung-Chi Cheng
Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.
Antimicrobial agents and chemotherapy 2004;48(5):1640-6.
2004: Wing Lam; Ying Li; Jieh-Yuan Liou; Ginger E Dutschman; Yung-Chi Cheng
Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates.
Molecular pharmacology 2004;65(2):400-6.
2004: Hiroki Kumamoto; Keisuke Kato; Kazuhiro Haraguchi; Hiromichi Tanaka; Takao Nitanda; Masanori Baba; Ginger E Dutschman; Yung-Chi Cheng
Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.
Nucleic acids symposium series (2004) 2004;(48):41-2.
2004: Kazuhiro Haraguchi; Yoshiharu Itoh; Shingo Takeda; Yosuke Honma; Hiromichi Tanaka; Takao Nitanda; Masanori Baba; Ginger E Dutschman; Yung-Chi Cheng
Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.
Nucleosides, nucleotides & nucleic acids 2004;23(4):647-54.
2003: Kazuhiro Haraguchi; Shingo Takeda; Hiromichi Tanaka; Takao Nitanda; Masanori Baba; Ginger E Dutschman; Yung-Chi Cheng
Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.
Bioorganic & medicinal chemistry letters 2003;13(21):3775-7.
2003: Preethi Krishnan; Elizabeth Gullen; Wing Lam; Ginger E Dutschman; Susan P Grill; Yung-Chi Cheng
Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents.
The Journal of biological chemistry 2003;278(38):36726-32.
2003: Jieh-Yuan Liou; Preethi Krishnan; Cheng-Chih Hsieh; Ginger E Dutschman; Yung-Chi Cheng
Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase.
Molecular pharmacology 2003;63(1):105-10.
2002: Jieh-Yuan Liou; Ginger E Dutschman; Wing Lam; Zaoli Jiang; Yung-Chi Cheng
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
Cancer research 2002;62(6):1624-31.
2002: Preethi Krishnan; Qin Fu; Wing Lam; Jieh-Yuan Liou; Ginger E Dutschman; Yung-Chi Cheng
Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase.
The Journal of biological chemistry 2002;277(7):5453-9.
2001: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents.
Nucleosides, nucleotides & nucleic acids 2001;20(12):1975-2000.
2001: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of L- and D-configurations of 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine analogues.
Bioorganic & medicinal chemistry letters 2001;11(17):2301-4.
2000: T Kira; Susan P Grill; Ginger E Dutschman; J S Lin; F Qu; Yongseok Choi; Chung (David) K. Chu; Yung-Chi Cheng
Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase.
Antimicrobial agents and chemotherapy 2000;44(12):3278-84.
2000: Ling Li; Ginger E Dutschman; Elizabeth Gullen; E Tsujii; Susan P Grill; Yongseok Choi; Chung (David) K. Chu; Yung-Chi Cheng
Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.
Molecular pharmacology 2000;58(5):1109-14.
2000: Mei-Zhen Luo; Mao-Chin Liu; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.
Bioorganic & medicinal chemistry letters 2000;10(18):2145-8.
2000: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; Alan C Sartorelli
Synthesis and biological evaluation of 1,3-oxathiolane 5-azapyrimidine, 6-azapyrimidine, and fluorosubstituted 3-deazapyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(3):603-18.
1999: Mao-Chin Liu; Mei-Zhen Luo; Diane E Mozdziesz; TS Lin; Ginger E Dutschman; Yung-Chi Cheng; Alan C Sartorelli
Synthesis of 2'-methylene-substituted 5-azapyrimidine, 6-azapyrimidine, and 3-deazaguanine nucleoside analogues as potential antitumor/antiviral agents.
Nucleosides & nucleotides 1999;18(1):55-72.
1998: Shu-Hui Chen; S Lin; Ivan King; T Spinka; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; TW Doyle
Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.
Bioorganic & medicinal chemistry letters 1998;8(22):3245-50.
1998: Shu-Hui Chen; Q Wang; J Mao; Ivan King; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng; TW Doyle
Synthesis and biological evaluation of a series of 2'-fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.
Bioorganic & medicinal chemistry letters 1998;8(13):1589-94.
1998: Ginger E Dutschman; EG Bridges; SH Liu; Elizabeth Gullen; X Guo; Marina K Kukhanova; Yung-Chi Cheng
Metabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitro.
Antimicrobial agents and chemotherapy 1998;42(7):1799-804.
1998: Rekha B Pai; S Balakrishna Pai; Marina K Kukhanova; Ginger E Dutschman; X Guo; Yung-Chi Cheng
Telomerase from human leukemia cells: properties and its interaction with deoxynucleoside analogues.
Cancer research 1998;58(9):1909-13.
1996: T S Lin; M Z Luo; Mao-Chin Liu; Y L Zhu; Elizabeth Gullen; Ginger E Dutschman; Yung-Chi Cheng
Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.
Journal of medicinal chemistry 1996;39(9):1757-9.
1996: E G Bridges; Ginger E Dutschman; Elizabeth Gullen; Yung-Chi Cheng
Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus.
Biochemical pharmacology 1996;51(6):731-6.
1995: G Piras; Ginger E Dutschman; G J Im; B C Pan; S H Chu; Yung-Chi Cheng
Action of uracil analogs on human immunodeficiency virus type 1 and its reverse transcriptase.
Antimicrobial agents and chemotherapy 1995;39(2):539-41.
1994: Yun Yen; S P Grill; Ginger E Dutschman; C N Chang; Bing-Sen Zhou; Yung-Chi Cheng
Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine.
Cancer research 1994;54(14):3686-91.
1994: T S Lin; M Z Luo; Mao-Chin Liu; S Balakrishna Pai; Ginger E Dutschman; Yung-Chi Cheng
Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).
Journal of medicinal chemistry 1994;37(6):798-803.
1994: T S Lin; M Z Luo; Mao-Chin Liu; S Balakrishna Pai; Ginger E Dutschman; Yung-Chi Cheng
Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro.
Biochemical pharmacology 1994;47(2):171-4.
1993: V Skalski; C N Chang; Ginger E Dutschman; Yung-Chi Cheng
The biochemical basis for the differential anti-human immunodeficiency virus activity of two cis enantiomers of 2',3'-dideoxy-3'-thiacytidine.
The Journal of biological chemistry 1993;268(31):23234-8.
1993: T S Lin; J L Zhu; Ginger E Dutschman; Yung-Chi Cheng; W H Prusoff
Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides.
Journal of medicinal chemistry 1993;36(3):353-62.
1993: J W Mellors; G J Im; Enzo Tramontano; S R Winkler; Medina Daniel; Ginger E Dutschman; H Z Bazmi; G Piras; C J Gonzalez; Yung-Chi Cheng
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150).
Molecular pharmacology 1993;43(1):11-6.
1992: J W Mellors; Ginger E Dutschman; G J Im; Enzo Tramontano; S R Winkler; Yung-Chi Cheng
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase.
Molecular pharmacology 1992;41(3):446-51.
1991: Herbert E Kaufman; Emily D Varnell; Yung-Chi Cheng; M Bobek; Hilary W Thompson; Ginger E Dutschman
Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys.
Antiviral research 1991;16(3):227-32.
1989: W Y Gao; Cy A Stein; J S Cohen; Ginger E Dutschman; Yung-Chi Cheng
Effect of phosphorothioate homo-oligodeoxynucleotides on herpes simplex virus type 2-induced DNA polymerase.
The Journal of biological chemistry 1989;264(19):11521-6.
1989: G A Lewandowski; S P Grill; M H Fisher; Ginger E Dutschman; S M Efange; T J Bardos; Yung-Chi Cheng
Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides.
Antimicrobial agents and chemotherapy 1989;33(3):340-4.
1987: M Bobek; I Kavai; R A Sharma; S Grill; Ginger E Dutschman; Yung-Chi Cheng
Acetylenic nucleosides. 4. 1-beta-D-arabinofuranosyl-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties.
Journal of medicinal chemistry 1987;30(11):2154-7.
1987: J S Li; Bing-Sen Zhou; Ginger E Dutschman; S P Grill; R S Tan; Y C Cheng
Association of Epstein-Barr virus early antigen diffuse component and virus-specified DNA polymerase activity.
Journal of virology 1987;61(9):2947-9.
1987: L M Nutter; S P Grill; Ginger E Dutschman; R A Sharma; M Bobek; Yung-Chi Cheng
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.
Antimicrobial agents and chemotherapy 1987;31(3):368-74.
1987: Yung-Chi Cheng; Ginger E Dutschman; Kenneth F Bastow; M G Sarngadharan; R Y Ting
Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.
The Journal of biological chemistry 1987;262(5):2187-9.
1986: T Ueda; Ginger E Dutschman; M G Nair; J I Degraw; F M Sirotnak; Y C Cheng
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Molecular pharmacology 1986;30(2):149-53.
1985: Yung-Chi Cheng; Ginger E Dutschman; M C Starnes; M H Fisher; N T Nanavathi; M G Nair
Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.
Cancer research 1985;45(2):598-600.
1984: Yung-Chi Cheng; S P Grill; Ginger E Dutschman; K B Frank; J F Chiou; Kenneth F Bastow; K Nakayama
Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.
Antimicrobial agents and chemotherapy 1984;26(3):283-8.
1983: Yung-Chi Cheng; S P Grill; Ginger E Dutschman; K Nakayama; Kenneth F Bastow
Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells.
The Journal of biological chemistry 1983;258(20):12460-4.
1983: Yung-Chi Cheng; Eng-Shang Huang; J C Lin; E C Mar; Joseph S Pagano; Ginger E Dutschman; S P Grill
Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(9):2767-70.
1983: Y C Cheng; R S Tan; J L Ruth; Ginger E Dutschman
Cytotoxicity of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine and its relationship to deoxycytidine deaminase.
Biochemical pharmacology 1983;32(4):726-9.
1982: Yung-Chi Cheng; Ray F Schinazi; Ginger E Dutschman; R S Tan; S P Grill
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
Journal of virological methods 1982;5(3-4):209-17.
1981: Yung-Chi Cheng; D Derse; R S Tan; Ginger E Dutschman; M Bobek; A Schroeder; Alexander Bloch
Biological and biochemical effects of 2'-azido-2'-deoxyarabinofuranosylcytosine on human tumor cells in vitro.
Cancer research 1981;41(8):3144-9.