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Raymond Dwek

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Phenomena

Chemicals & Drugs

Genes & Molecular Sequences

Carbohydrate Sequence

Concepts & Ideas

Living Beings

Mice

Procedures

Anatomy

Cell Line

Physiology

Protein Folding

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Co-Publications
Name
112
Rudd, Pauline
69
Butters, Terry
68
Harvey, David
62
Wormald, Mark
59
Platt, Frances
35
Royle, Louise
34
Zitzmann, Nicole
24
Radcliffe, Catherine
23
Block, Timothy
17
Petrescu, Stefana
17
Wilson, Ian
15
Opdenakker, Ghislain
15
Branza-Nichita, Norica
14
Jeyakumar, Mylvaganam
13
Burton, Dennis

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Publications

TOP 3
Harvey David J; Merry Anthony H; Royle Louise; Campbell Matthew P; Dwek Raymond A; Rudd Pauline M
Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds.
Luik Philipp; Chew Chee; Aittoniemi Jussi; Chang Jason; Wentworth Paul; Dwek Raymond A; Biggin Philip C; Vénien-Bryan Catherine; Zitzmann Nicole
The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.
Crispin Max; Chang Veronica T; Harvey David J; Dwek Raymond A; Evans Edward J; Stuart David I; Jones E Yvonne; Lord J Michael; Spooner Robert A; Davis Simon J
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.

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All Publications

2009: Harvey David J; Merry Anthony H; Royle Louise; Campbell Matthew P; Dwek Raymond A; Rudd Pauline M
Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds.
Proteomics 2009;9(15):3796-801.
2009: Luik Philipp; Chew Chee; Aittoniemi Jussi; Chang Jason; Wentworth Paul; Dwek Raymond A; Biggin Philip C; Vénien-Bryan Catherine; Zitzmann Nicole
The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12712-6.
2009: Crispin Max; Chang Veronica T; Harvey David J; Dwek Raymond A; Evans Edward J; Stuart David I; Jones E Yvonne; Lord J Michael; Spooner Robert A; Davis Simon J
A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus.
The Journal of biological chemistry 2009;284(32):21684-95.
2009: Su Yunpeng; Royle Louise; Radcliffe Catherine M; Harvey David J; Dwek Raymond A; Martinez-Pomares Luisa; Rudd Pauline M
Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation.
Biochemical and biophysical research communications 2009;384(4):436-43.
2009: Rawlings Amy J; Lomas Hannah; Pilling Adam W; Lee Marvin J-R; Alonzi Dominic S; Rountree J S Shane; Jenkinson Sarah F; Fleet George W J; Dwek Raymond A; Jones John H; Butters Terry D
Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.
Chembiochem : a European journal of chemical biology 2009;10(6):1101-5.
2009: Mackeen Mukram M; Almond Andrew; Deschamps Michael; Cumpstey Ian; Fairbanks Antony J; Tsang Clarence; Rudd Pauline M; Butters Terry D; Dwek Raymond A; Wormald Mark R
The conformational properties of the Glc3Man unit suggest conformational biasing within the chaperone-assisted glycoprotein folding pathway.
Journal of molecular biology 2009;387(2):335-47.
2009: Rountree J S Shane; Butters Terry D; Wormald Mark R; Boomkamp Stephanie D; Dwek Raymond A; Asano Naoki; Ikeda Kyoko; Evinson Emma L; Nash Robert J; Fleet George W J
Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.
ChemMedChem 2009;4(3):378-92.
2009: Neville David C A; Dwek Raymond A; Butters Terry D
Development of a single column method for the separation of lipid- and protein-derived oligosaccharides.
Journal of proteome research 2009;8(2):681-7.
2009: Montesino Raquel; Toledo Jorge R; Sanchez Oliberto; Zamora Yasser; Barrera Maritza; Royle Louise; Rudd Pauline M; Dwek Raymond A; Harvey David J; Cremata Jose A
N-glycosylation pattern of E2 glycoprotein from classical swine fever virus.
Journal of proteome research 2009;8(2):546-55.
2009: Narayan Ramamurthy; Gangadharan Bevin; Hantz Olivier; Antrobus Robin; García Angela; Dwek Raymond A; Zitzmann Nicole
Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.
Journal of proteome research 2009;8(1):118-22.
2009: Jimenez-Dalmaroni Maximiliano J; Xiao Nengming; Corper Adam L; Verdino Petra; Ainge Gary D; Larsen Dave S; Painter Gavin F; Rudd Pauline M; Dwek Raymond A; Hoebe Kasper; Beutler Bruce; Wilson Ian A
Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.
PloS one 2009;4(10):e7411.
2008: Abd Hamid Umi M; Royle Louise; Saldova Radka; Radcliffe Catherine M; Harvey David J; Storr Sarah J; Pardo Maria; Antrobus Robin; Chapman Caroline J; Zitzmann Nicole; Robertson John F; Dwek Raymond A; Rudd Pauline M
A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression.
Glycobiology 2008;18(12):1105-18.
2008: Xu Xiaojin; Zhu Xueyong; Dwek Raymond A; Stevens James; Wilson Ian A
Structural characterization of the 1918 influenza virus H1N1 neuraminidase.
Journal of virology 2008;82(21):10493-501.
2008: Royle Louise; Matthews Elizabeth; Corfield Anthony; Berry Monica; Rudd Pauline M; Dwek Raymond A; Carrington Stephen D
Glycan structures of ocular surface mucins in man, rabbit and dog display species differences.
Glycoconjugate journal 2008;25(8):763-73.
2008: Dunlop D Cameron; Ulrich Alexander; Appelmelk Ben J; Burton Dennis R; Dwek Raymond A; Zitzmann Nicole; Scanlan Christopher N
Antigenic mimicry of the HIV envelope by AIDS-associated pathogens.
AIDS (London, England) 2008;22(16):2214-7.
2008: Pollock Stephanie; Dwek Raymond A; Burton Dennis R; Zitzmann Nicole
N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery.
AIDS (London, England) 2008;22(15):1961-9.
2008: Séveno Martial; Cabrera Gleysin; Triguero Ada; Burel Carole; Leprince Jérome; Rihouey Christophe; Vézina Louis-Philippe; D'Aoust Marc-André; Rudd Pauline M; Royle L; Dwek Raymond A; Harvey David J; Lerouge Patrice; Cremata José A; Bardor Muriel
Plant N-glycan profiling of minute amounts of material.
Analytical biochemistry 2008;379(1):66-72.
2008: Astronomo Rena D; Lee Hing-Ken; Scanlan Christopher N; Pantophlet Ralph; Huang Cheng-Yuan; Wilson Ian A; Blixt Ola; Dwek Raymond A; Wong Chi-Huey; Burton Dennis R
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
Journal of virology 2008;82(13):6359-68.
2008: Elliot-Smith Elena; Speak Anneliese O; Lloyd-Evans Emyr; Smith David A; van der Spoel Aarnoud C; Jeyakumar Mylvaganam; Butters Terry D; Dwek Raymond A; d'Azzo Alessandra; Platt Frances M
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Molecular genetics and metabolism 2008;94(2):204-11.
2008: Storr Sarah J; Royle Louise; Chapman Caroline J; Hamid Umi M Abd; Robertson John F; Murray Andrea; Dwek Raymond A; Rudd Pauline M
The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum.
Glycobiology 2008;18(6):456-62.
2008: Campbell Matthew P; Royle Louise; Radcliffe Catherine M; Dwek Raymond A; Rudd Pauline M
GlycoBase and autoGU: tools for HPLC-based glycan analysis.
Bioinformatics (Oxford, England) 2008;24(9):1214-6.
2008: Woodhouse Stephen D; Smith Caroline; Michelet Maud; Branza-Nichita Norica; Hussey Mark; Dwek Raymond A; Zitzmann Nicole
Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells.
Antimicrobial agents and chemotherapy 2008;52(5):1820-8.
2008: Harvey David J; Royle Louise; Radcliffe Catherine M; Rudd Pauline M; Dwek Raymond A
Structural and quantitative analysis of N-linked glycans by matrix-assisted laser desorption ionization and negative ion nanospray mass spectrometry.
Analytical biochemistry 2008;376(1):44-60.
2008: Royle Louise; Campbell Matthew P; Radcliffe Catherine M; White Dawn M; Harvey David J; Abrahams Jodie L; Kim Yun-Gon; Henry George W; Shadick Nancy A; Weinblatt Michael E; Lee David M; Rudd Pauline M; Dwek Raymond A
HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software.
Analytical biochemistry 2008;376(1):1-12.
2008: Kim Yun-Gon; Shin Dong-Sik; Yang Yung-Hun; Gil Geun-Cheol; Park Chung-Gyu; Mimura Yusuke; Cooper David K C; Rudd Pauline M; Dwek Raymond A; Lee Yoon-Sik; Kim Byung-Gee
High-throughput screening of glycan-binding proteins using miniature pig kidney N-glycan-immobilized beads.
Chemistry & biology 2008;15(3):215-23.
2008: Scanlan Christopher N; Burton Dennis R; Dwek Raymond A
Making autoantibodies safe.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4081-2.
2008: McCann Katy J; Ottensmeier Christian H; Callard Alice; Radcliffe Catherine M; Harvey David J; Dwek Raymond A; Rudd Pauline M; Sutton Brian J; Hobby Paul; Stevenson Freda K
Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma.
Molecular immunology 2008;45(6):1567-72.
2008: Miller Joanna L; deWet Barend J M; Martinez-Pomares Luisa; Radcliffe Catherine M; Dwek Raymond A; Rudd Pauline M; Gordon Siamon
The mannose receptor mediates dengue virus infection of macrophages.
PLoS pathogens 2008;4(2):e17.
2008: Priestman D A; van der Spoel A C; Butters T D; Dwek R A; Platt F M
N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.
Diabetes, obesity & metabolism 2008;10(2):159-66.
2008: Mehta Anand S; Long Ronald E; Comunale Mary Ann; Wang Mengjun; Rodemich Lucy; Krakover Jonathan; Philip Ramila; Marrero Jorge A; Dwek Raymond A; Block Timothy M
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis.
Journal of virology 2008;82(3):1259-70.
2008: Alonzi Dominic S; Neville David C A; Lachmann Robin H; Dwek Raymond A; Butters Terry D
Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.
The Biochemical journal 2008;409(2):571-80.
2008: Saldova Radka; Wormald Mark R; Dwek Raymond A; Rudd Pauline M
Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis.
Disease markers 2008;25(4-5):219-32.
2007: Gornik Olga; Royle Louise; Harvey David J; Radcliffe Catherine M; Saldova Radka; Dwek Raymond A; Rudd Pauline; Lauc Gordan
Changes of serum glycans during sepsis and acute pancreatitis.
Glycobiology 2007;17(12):1321-32.
2007: Saldova Radka; Royle Louise; Radcliffe Catherine M; Abd Hamid Umi M; Evans Rachel; Arnold James N; Banks Rosamonde E; Hutson Richard; Harvey David J; Antrobus Robin; Petrescu Stefana M; Dwek Raymond A; Rudd Pauline M
Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.
Glycobiology 2007;17(12):1344-56.
2007: Walden Charlotte M; Sandhoff Roger; Chuang Chia-Chen; Yildiz Yildiz; Butters Terry D; Dwek Raymond A; Platt Frances M; van der Spoel Aarnoud C
Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
The Journal of biological chemistry 2007;282(45):32655-64.
2007: Gangadharan Bevin; Antrobus Robin; Dwek Raymond A; Zitzmann Nicole
Novel serum biomarker candidates for liver fibrosis in hepatitis C patients.
Clinical chemistry 2007;53(10):1792-9.
2007: Lazar Catalin; Durantel David; Macovei Alina; Zitzmann Nicole; Zoulim Fabien; Dwek Raymond A; Branza-Nichita Norica
Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.
Antiviral research 2007;76(1):30-7.
2007: Scanlan Christopher N; Ritchie Gayle E; Baruah Kavitha; Crispin Max; Harvey David J; Singer Bernhard B; Lucka Lothar; Wormald Mark R; Wentworth Paul; Zitzmann Nicole; Rudd Pauline M; Burton Dennis R; Dwek Raymond A
Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.
Journal of molecular biology 2007;372(1):16-22.
2007: Steinmann Eike; Whitfield Thomas; Kallis Stephanie; Dwek Raymond A; Zitzmann Nicole; Pietschmann Thomas; Bartenschlager Ralf
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.
Hepatology (Baltimore, Md.) 2007;46(2):330-8.
2007: Pardo María; García Angel; Antrobus Robin; Blanco María José; Dwek Raymond A; Zitzmann Nicole
Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.
Journal of proteome research 2007;6(7):2802-11.
2007: Crispin Max; Aricescu A Radu; Chang Veronica T; Jones E Yvonne; Stuart David I; Dwek Raymond A; Davis Simon J; Harvey David J
Disruption of alpha-mannosidase processing induces non-canonical hybrid-type glycosylation.
FEBS letters 2007;581(10):1963-8.
2007: Ziólkowska Natasza E; Shenoy Shilpa R; O'Keefe Barry R; McMahon James B; Palmer Kenneth E; Dwek Raymond A; Wormald Mark R; Wlodawer Alexander
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins 2007;67(3):661-70.
2007: Scanlan Christopher N; Offer John; Zitzmann Nicole; Dwek Raymond A
Exploiting the defensive sugars of HIV-1 for drug and vaccine design.
Nature 2007;446(7139):1038-45.
2007: Pardo María; Dwek Raymond A; Zitzmann Nicole
Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery.
Expert review of proteomics 2007;4(2):273-86.
2007: Mimura Yusuke; Mimura-Kimura Yuka; Doores Katie; Golgher Denise; Davis Benjamin G; Dwek Raymond A; Rudd Pauline M; Elliott Tim
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5983-8.
2007: Chapel Cynthia; Garcia Céline; Bartosch Birke; Roingeard Philippe; Zitzmann Nicole; Cosset François-Loïc; Dubuisson Jean; Dwek Raymond A; Trépo Christian; Zoulim Fabien; Durantel David
Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors.
The Journal of general virology 2007;88(Pt 4):1133-43.
2007: Speak Anneliese O; Salio Mariolina; Neville David C A; Fontaine Josette; Priestman David A; Platt Nick; Heare Tanya; Butters Terry D; Dwek Raymond A; Trottein Francois; Exley Mark A; Cerundolo Vincenzo; Platt Frances M
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5971-6.
2007: Lee Jean-Pyo; Jeyakumar Mylvaganam; Gonzalez Rodolfo; Takahashi Hiroto; Lee Pei-Jen; Baek Rena C; Clark Dan; Rose Heather; Fu Gerald; Clarke Jonathan; McKercher Scott; Meerloo Jennifer; Muller Franz-Josef; Park Kook In; Butters Terry D; Dwek Raymond A; Schwartz Philip; Tong Gang; Wenger David; Lipton Stuart A; Seyfried Thomas N; Platt Frances M; Snyder Evan Y
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
Nature medicine 2007;13(4):439-47.
2007: Barrabés Sílvia; Pagès-Pons Lluís; Radcliffe Catherine M; Tabarés Glòria; Fort Esther; Royle Louise; Harvey David J; Moenner Michel; Dwek Raymond A; Rudd Pauline M; De Llorens Rafael; Peracaula Rosa
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer.
Glycobiology 2007;17(4):388-400.
2007: Wada Yoshinao; Azadi Parastoo; Costello Catherine E; Dell Anne; Dwek Raymond A; Geyer Hildegard; Geyer Rudolf; Kakehi Kazuaki; Karlsson Niclas G; Kato Koichi; Kawasaki Nana; Khoo Kay-Hooi; Kim Soohyun; Kondo Akihiro; Lattova Erika; Mechref Yehia; Miyoshi Eiji; Nakamura Kazuyuki; Narimatsu Hisashi; Novotny Milos V; Packer Nicolle H; Perreault Hélène; Peter-Katalinic Jasna; Pohlentz Gottfried; Reinhold Vernon N; Rudd Pauline M; Suzuki Akemi; Taniguchi Naoyuki
Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.
Glycobiology 2007;17(4):411-22.
2007: Chang Veronica T; Crispin Max; Aricescu A Radu; Harvey David J; Nettleship Joanne E; Fennelly Janet A; Yu Chao; Boles Kent S; Evans Edward J; Stuart David I; Dwek Raymond A; Jones E Yvonne; Owens Raymond J; Davis Simon J
Glycoprotein structural genomics: solving the glycosylation problem.
Structure (London, England : 1993) 2007;15(3):267-73.
2007: Radcliffe Catherine M; Arnold James N; Suter David M; Wormald Mark R; Harvey David J; Royle Louise; Mimura Yusuke; Kimura Yoshinobu; Sim Robert B; Inogès Susana; Rodriguez-Calvillo Mercedes; Zabalegui Natalia; de Cerio Ascensión López-Díaz; Potter Kathleen N; Mockridge C Ian; Dwek Raymond A; Bendandi Maurizio; Rudd Pauline M; Stevenson Freda K
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
The Journal of biological chemistry 2007;282(10):7405-15.
2007: Heare T; Alp N J; Priestman D A; Kulkarni A B; Qasba P; Butters T D; Dwek R A; Clarke K; Channon K M; Platt F M
Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.
Journal of inherited metabolic disease 2007;30(1):79-87.
2007: Robijn Marjolein L M; Koeleman Carolien A M; Wuhrer Manfred; Royle Louise; Geyer Rudolf; Dwek Raymond A; Rudd Pauline M; Deelder André M; Hokke Cornelis H
Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody.
Molecular and biochemical parasitology 2007;151(2):148-61.
2007: Arnold James N; Wormald Mark R; Sim Robert B; Rudd Pauline M; Dwek Raymond A
The impact of glycosylation on the biological function and structure of human immunoglobulins.
Annual review of immunology 2007;25():21-50.
2006: Fry Simon A; Van den Steen Philippe E; Royle Louise; Wormald Mark R; Leathem Anthony J; Opdenakker Ghislain; McDonnell James M; Dwek Raymond A; Rudd Pauline M
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.
Biochemistry 2006;45(51):15249-58.
2006: Oortwijn Beatrijs D; Roos Anja; Royle Louise; van Gijlswijk-Janssen Daniëlle J; Faber-Krol Maria C; Eijgenraam Jan-Willem; Dwek Raymond A; Daha Mohamed R; Rudd Pauline M; van Kooten Cees
Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy.
Journal of the American Society of Nephrology : JASN 2006;17(12):3529-39.
2006: Omtvedt Lone A; Royle Louise; Husby Gunnar; Sletten Knut; Radcliffe Catherine M; Harvey David J; Dwek Raymond A; Rudd Pauline M
Glycan analysis of monoclonal antibodies secreted in deposition disorders indicates that subsets of plasma cells differentially process IgG glycans.
Arthritis and rheumatism 2006;54(11):3433-40.
2006: Tsiftsoglou Stefanos A; Arnold James N; Roversi Pietro; Crispin Max D; Radcliffe Catherine; Lea Susan M; Dwek Raymond A; Rudd Pauline M; Sim Robert B
Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.
Biochimica et biophysica acta 2006;1764(11):1757-66.
2006: Jayachandran Rajesh; Radcliffe Catherine M; Royle Louise; Harvey David J; Dwek Raymond A; Rudd Pauline M; Karande Anjali A
Oligosaccharides modulate the apoptotic activity of glycodelin.
Glycobiology 2006;16(11):1052-63.
2006: Gadola Stephan D; Silk Jonathan D; Jeans Aruna; Illarionov Petr A; Salio Mariolina; Besra Gurdyal S; Dwek Raymond; Butters Terry D; Platt Frances M; Cerundolo Vincenzo
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
The Journal of experimental medicine 2006;203(10):2293-303.
2006: Bardor Muriel; Cabrera Gleysin; Rudd Pauline M; Dwek Raymond A; Cremata José A; Lerouge Patrice
Analytical strategies to investigate plant N-glycan profiles in the context of plant-made pharmaceuticals.
Current opinion in structural biology 2006;16(5):576-83.
2006: García Angel; Senis Yotis A; Antrobus Robin; Hughes Craig E; Dwek Raymond A; Watson Steve P; Zitzmann Nicole
A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.
Proteomics 2006;6(19):5332-43.
2006: Petrescu Andrei-José; Wormald Mark R; Dwek Raymond A
Structural aspects of glycomes with a focus on N-glycosylation and glycoprotein folding.
Current opinion in structural biology 2006;16(5):600-7.
2006: Knight Christopher G; Zitzmann Nicole; Prabhakar Sripadi; Antrobus Robin; Dwek Raymond; Hebestreit Holger; Rainey Paul B
Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network.
Nature genetics 2006;38(9):1015-22.
2006: van Thor Jasper J; Mackeen Mukram; Kuprov Ilya; Dwek Raymond A; Wormald Mark R
Chromophore structure in the photocycle of the cyanobacterial phytochrome Cph1.
Biophysical journal 2006;91(5):1811-22.
2006: Pardo María; García Angel; Thomas Benjamin; Piñeiro Antonio; Akoulitchev Alexandre; Dwek Raymond A; Zitzmann Nicole
The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker.
International journal of cancer. Journal international du cancer 2006;119(5):1014-22.
2006: Burton Dennis R; Dwek Raymond A
Immunology. Sugar determines antibody activity.
Science (New York, N.Y.) 2006;313(5787):627-8.
2006: Arnold James N; Dwek Raymond A; Rudd Pauline M; Sim Robert B
Mannan binding lectin and its interaction with immunoglobulins in health and in disease.
Immunology letters 2006;106(2):103-10.
2006: Macovei Alina; Zitzmann Nicole; Lazar Catalin; Dwek Raymond A; Branza-Nichita Norica
Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity.
Biochemical and biophysical research communications 2006;346(3):1083-90.
2006: Popescu Costin I; Mares Alina; Zdrentu Livia; Zitzmann Nicole; Dwek Raymond A; Petrescu Stefana M
Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor.
The Journal of biological chemistry 2006;281(31):21682-9.
2006: Crispin Max; Harvey David J; Chang Veronica T; Yu Chao; Aricescu A Radu; Jones E Yvonne; Davis Simon J; Dwek Raymond A; Rudd Pauline M
Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway.
Glycobiology 2006;16(8):748-56.
2006: Webber Dawn; Radcliffe Catherine M; Royle Louise; Tobiasen Gemma; Merry Anthony H; Rodgers Allen L; Sturrock Edward D; Wormald Mark R; Harvey David J; Dwek Raymond A; Rudd Pauline M
Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation.
The FEBS journal 2006;273(13):3024-37.
2006: Van den Steen Philippe E; Van Aelst Ilse; Hvidberg Vibeke; Piccard Helene; Fiten Pierre; Jacobsen Christian; Moestrup Soren K; Fry Simon; Royle Louise; Wormald Mark R; Wallis Russell; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
2006: Wopereis Suzan; Abd Hamid Umi M; Critchley Alison; Royle Louise; Dwek Raymond A; Morava Eva; Leroy Jules G; Wilcken Bridget; Lagerwerf Aart J; Huijben Karin M L C; Lefeber Dirk J; Rudd Pauline M; Wevers Ron A
Abnormal glycosylation with hypersialylated O-glycans in patients with Sialuria.
Biochimica et biophysica acta 2006;1762(6):598-607.
2006: Mackeen Mukram; Almond Andrew; Cumpstey Ian; Enis Seth C; Kupce Eriks; Butters Terry D; Fairbanks Antony J; Dwek Raymond A; Wormald Mark R
The importance of including local correlation times in the calculation of inter-proton distances from NMR measurements: ignoring local correlation times leads to significant errors in the conformational analysis of the Glc alpha1-2Glc alpha linkage by NMR spectroscopy.
Organic & biomolecular chemistry 2006;4(11):2241-6.
2006: Jacquemin M; Radcliffe C M; Lavend'homme R; Wormald M R; Vanderelst L; Wallays G; Dewaele J; Collen D; Vermylen J; Dwek R A; Saint-Remy J-M; Rudd P M; Dewerchin M
Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody.
Journal of thrombosis and haemostasis : JTH 2006;4(5):1047-55.
2006: Walden Charlotte M; Butters Terry D; Dwek Raymond A; Platt Frances M; van der Spoel Aarnoud C
Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin.
Human reproduction (Oxford, England) 2006;21(5):1309-15.
2006: Doores Katie J; Mimura Yusuke; Dwek Raymond A; Rudd Pauline M; Elliott Tim; Davis Benjamin G
Direct deprotected glycosyl-asparagine ligation.
Chemical communications (Cambridge, England) 2006;(13):1401-3.
2006: Shore D A; Teyton L; Dwek R A; Rudd P M; Wilson I A
Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.
Journal of molecular biology 2006;358(2):347-54.
2006: Chapel Cynthia; Garcia Céline; Roingeard Philippe; Zitzmann Nicole; Dubuisson Jean; Dwek Raymond A; Trépo Christian; Zoulim Fabien; Durantel David
Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.
The Journal of general virology 2006;87(Pt 4):861-71.
2006: Opdenakker Ghislain; Dillen Chris; Fiten Pierre; Martens Erik; Van Aelst Ilse; Van den Steen Philippe E; Nelissen Inge; Starckx Sofie; Descamps Francis J; Hu Jialiang; Piccard Helene; Van Damme Jo; Wormald Mark R; Rudd Pauline M; Dwek Raymond A
Remnant epitopes, autoimmunity and glycosylation.
Biochimica et biophysica acta 2006;1760(4):610-5.
2006: Harvey David J; Dwek Raymond A; Rudd Pauline M
Determining the structure of glycan moieties by mass spectrometry.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2006;Chapter 12():Unit 12.7.
2006: Royle Louise; Dwek Raymond A; Rudd Pauline M
Determining the structure of oligosaccharides N- and O-linked to glycoproteins.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2006;Chapter 12():Unit 12.6.
2006: Block Timothy M; Mehta Anand S; Blumberg Baruch S; Dwek Raymond A
Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?
DNA and cell biology 2006;25(3):165-70.
2006: Arnold James N; Wallis Russell; Willis Antony C; Harvey David J; Royle Louise; Dwek Raymond A; Rudd Pauline M; Sim Robert B
Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
The Journal of biological chemistry 2006;281(11):6955-63.
2006: Kim Yun-Gon; Kim Sun-Young; Hur Young-Mi; Joo Hwang-Soo; Chung Junho; Lee Dong-Sup; Royle Louise; Rudd Pauline M; Dwek Raymond A; Harvey David J; Kim Byung-Gee
The identification and characterization of xenoantigenic nonhuman carbohydrate sequences in membrane proteins from porcine kidney.
Proteomics 2006;6(4):1133-42.
2006: Tabarés Glòria; Radcliffe Catherine M; Barrabés Sílvia; Ramírez Manel; Aleixandre R Núria; Hoesel Wolfgang; Dwek Raymond A; Rudd Pauline M; Peracaula Rosa; de Llorens Rafael
Different glycan structures in prostate-specific antigen from prostate cancer sera in relation to seminal plasma PSA.
Glycobiology 2006;16(2):132-45.
2006: Patargias George; Zitzmann Nicole; Dwek Raymond; Fischer Wolfgang B
Protein-protein interactions: modeling the hepatitis C virus ion channel p7.
Journal of medicinal chemistry 2006;49(2):648-55.
2006: Norris-Cervetto Edward; Butters Terry D; Martin Catherine; Modok Szabolcs; Dwek Raymond A; Callaghan Richard
Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?
European journal of pharmacology 2006;530(3):195-204.
2006: Royle Louise; Radcliffe Catherine M; Dwek Raymond A; Rudd Pauline M
Detailed structural analysis of N-glycans released from glycoproteins in SDS-PAGE gel bands using HPLC combined with exoglycosidase array digestions.
Methods in molecular biology (Clifton, N.J.) 2006;347():125-43.
2005: Simmons Alison; Gangadharan Bevin; Hodges Ashleigh; Sharrocks Katherine; Prabhakar Sripadi; García Angel; Dwek Raymond; Zitzmann Nicole; McMichael Andrew
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
Immunity 2005;23(6):621-34.
2005: Blériot Yves; Gretzke Dirk; Krülle Thomas M; Butters Terry D; Dwek Raymond A; Nash Robert J; Asano Naoki; Fleet George W J
Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin.
Carbohydrate research 2005;340(18):2713-8.
2005: Pardo María; García Angel; Thomas Benjamin; Piñeiro Antonio; Akoulitchev Alexandre; Dwek Raymond A; Zitzmann Nicole
Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS.
Proteomics 2005;5(18):4980-93.
2005: García Angel; Watson Steve P; Dwek Raymond A; Zitzmann Nicole
Applying proteomics technology to platelet research.
Mass spectrometry reviews 2005;24(6):918-30.
2005: Simsek Ender; Mehta Anand; Zhou Tianlun; Dwek Raymond A; Block Timothy
Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme.
Journal of virology 2005;79(20):12914-20.
2005: Butters Terry D; Dwek Raymond A; Platt Frances M
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
Glycobiology 2005;15(10):43R-52R.
2005: Jeyakumar Mylvaganam; Dwek Raymond A; Butters Terry D; Platt Frances M
Storage solutions: treating lysosomal disorders of the brain.
Nature reviews. Neuroscience 2005;6(9):713-25.
2005: Su Yunpeng; Bakker Talitha; Harris James; Tsang Clarence; Brown Gordon D; Wormald Mark R; Gordon Siamon; Dwek Raymond A; Rudd Pauline M; Martinez-Pomares Luisa
Glycosylation influences the lectin activities of the macrophage mannose receptor.
The Journal of biological chemistry 2005;280(38):32811-20.
2005: Arnold James N; Wormald Mark R; Suter David M; Radcliffe Catherine M; Harvey David J; Dwek Raymond A; Rudd Pauline M; Sim Robert B
Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.
The Journal of biological chemistry 2005;280(32):29080-7.
2005: Jerkovic Lidija; Voegele Andreas F; Chwatal Sabine; Kronenberg Florian; Radcliffe Catherine M; Wormald Mark R; Lobentanz Eva M; Ezeh Benjie; Eller Patricia; Dejori Norbert; Dieplinger Benjamin; Lottspeich Friedrich; Sattler Wolfgang; Uhr Manfred; Mechtler Karl; Dwek Raymond A; Rudd Pauline M; Baier Gottfried; Dieplinger Hans
Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.
Journal of proteome research 2005;4(3):889-99.
2005: Popescu Costin I; Paduraru Crina; Dwek Raymond A; Petrescu Stefana M
Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.
The Journal of biological chemistry 2005;280(14):13833-40.
2005: Suganuma Ryota; Walden Charlotte M; Butters Terry D; Platt Frances M; Dwek Raymond A; Yanagimachi Ryuzo; van der Spoel Aarnoud C
Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
Biology of reproduction 2005;72(4):805-13.
2005: Jorgensen-Tye B; Levesque J-P; Royle L; Doyonnas R; Chan J Y-H; Dwek R A; Rudd P M; Harvey D J; Simmons P J; Watt S M
Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis.
Tissue antigens 2005;65(3):220-39.
2005: Negroiu Gabriela; Dwek Raymond A; Petrescu Stefana M
Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells.
Biochemical and biophysical research communications 2005;328(4):914-21.
2005: Zajonc Dirk M; Crispin M D Max; Bowden Thomas A; Young David C; Cheng Tan-Yun; Hu Jingdan; Costello Catherine E; Rudd Pauline M; Dwek Raymond A; Miller Marvin J; Brenner Michael B; Moody D Branch; Wilson Ian A
Molecular mechanism of lipopeptide presentation by CD1a.
Immunity 2005;22(2):209-19.
2005: Block Timothy M; Comunale Mary Ann; Lowman Melissa; Steel Laura F; Romano Patrick R; Fimmel Claus; Tennant Bud C; London W Thomas; Evans Alison A; Blumberg Baruch S; Dwek Raymond A; Mattu Tajinder S; Mehta Anand S
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):779-84.
2005: Platt Frances M; Jeyakumar Mylvaganam; Andersson Ulrika; Dwek Raymond A; Butters Terry D
New developments in treating glycosphingolipid storage diseases.
Advances in experimental medicine and biology 2005;564():117-26.
2005: Fry Simon A; Van den Steen Philippe E; Royle Louise; Wormald Mark R; Leathem Anthony J; Opdenakker Ghislain; Rudd Pauline M; Dwek Raymond A
Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.
Advances in experimental medicine and biology 2005;564():103-12.
2005: Mimura Yusuke; Golgher Denise; Mimura-Kimura Yuka; Dwek Raymond A; Rudd Pauline M; Elliott Tim
Immunogenicity of calreticulin-bound murine leukemia virus glycoprotein gp90.
Advances in experimental medicine and biology 2005;564():85-94.
2005: Shore David A; Wilson Ian A; Dwek Raymond A; Rudd Pauline M
Glycosylation and the function of the T cell co-receptor CD8.
Advances in experimental medicine and biology 2005;564():71-84.
2005: Arnold James N; Royle Louise; Dwek Raymond A; Rudd Pauline M; Sim Robert B
Human immunoglobulin glycosylation and the lectin pathway of complement activation.
Advances in experimental medicine and biology 2005;564():27-43.
2005: Su Yunpeng Roc; Tsang Clarence; Bakker Talitha; Harris James; Gordon Siamon; Dwek Raymond A; Martinez-Pomares Luisa; Rudd Pauline M
Glycosylation influences the ligand binding activities of mannose receptor.
Advances in experimental medicine and biology 2005;564():25-6.
2005: Scanlan Chris; Calarese Daniel; Lee Hing-Ken; Blixt Ola; Wong Chi-Huey; Wilson Ian; Burton Dennis; Dwek Raymond; Rudd Pauline
Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design.
Advances in experimental medicine and biology 2005;564():7-8.
2005: Pavlovic D; Fischer W; Hussey M; Durantel D; Durantel S; Branza-Nichita N; Woodhouse S; Dwek R A; Zitzmann N
Long alkylchain iminosugars block the HCV p7 ion channel.
Advances in experimental medicine and biology 2005;564():3-4.
2005: Zitzmann Nicole; Block Timothy; Methta Anund; Rudd Pauline; Burton Dennis; Wilson Ian; Platt Frances; Butters Terry; Dwek Raymond A
Glycosylation: disease targets and therapy.
Advances in experimental medicine and biology 2005;564():1-2.
2004: Arnold James N; Radcliffe Catherine M; Wormald Mark R; Royle Louise; Harvey David J; Crispin Max; Dwek Raymond A; Sim Robert B; Rudd Pauline M
The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6831-40.
2004: O'Leary Joanne M; Radcliffe Catherine M; Willis Antony C; Dwek Raymond A; Rudd Pauline M; Downing A Kristina
Identification and removal of O-linked and non-covalently linked sugars from recombinant protein produced using Pichia pastoris.
Protein expression and purification 2004;38(2):217-27.
2004: Pardo María; Piñeiro Antonio; de la Fuente María; García Angel; Prabhakar Sripadi; Zitzmann Nicole; Dwek Raymond A; Sánchez-Salorio Manuel; Domínguez Fernando; Capeans Carmen
Abnormal cell cycle regulation in primary human uveal melanoma cultures.
Journal of cellular biochemistry 2004;93(4):708-20.
2004: Jeyakumar Mylvaganam; Smith David A; Williams Ian M; Borja Mario Cortina; Neville David C A; Butters Terry D; Dwek Raymond A; Platt Frances M
NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin.
Annals of neurology 2004;56(5):642-9.
2004: Simpson Michael A; Cross Harold; Proukakis Christos; Priestman David A; Neville David C A; Reinkensmeier Gabriele; Wang Heng; Wiznitzer Max; Gurtz Kay; Verganelaki Argyro; Pryde Anna; Patton Michael A; Dwek Raymond A; Butters Terry D; Platt Frances M; Crosby Andrew H
Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.
Nature genetics 2004;36(11):1225-9.
2004: Rudd Pauline M; Wormald Mark R; Dwek Raymond A
Sugar-mediated ligand-receptor interactions in the immune system.
Trends in biotechnology 2004;22(10):524-30.
2004: Yu Chu-Yi; Asano Naoki; Ikeda Kyoko; Wang Mei-Xiang; Butters Terry D; Wormald Mark R; Dwek Raymond A; Winters Ana L; Nash Robert J; Fleet George W J
Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.
Chemical communications (Cambridge, England) 2004;(17):1936-7.
2004: Norris-Cervetto Edward; Callaghan Richard; Platt Frances M; Dwek Raymond A; Butters Terry D
Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
The Journal of biological chemistry 2004;279(39):40412-8.
2004: Tian Gang; Wilcockson David; Perry V Hugh; Rudd Pauline M; Dwek Raymond A; Platt Frances M; Platt Nick
Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life.
The Journal of biological chemistry 2004;279(38):39303-9.
2004: Khalaila Isam; Peter-Katalinic Jasna; Tsang Clarence; Radcliffe Catherine M; Aflalo Eliahu D; Harvey David J; Dwek Raymond A; Rudd Pauline M; Sagi Amir
Structural characterization of the N-glycan moiety and site of glycosylation in vitellogenin from the decapod crustacean Cherax quadricarinatus.
Glycobiology 2004;14(9):767-74.
2004: Neville David C A; Coquard Virginie; Priestman David A; te Vruchte Danielle J M; Sillence Daniel J; Dwek Raymond A; Platt Frances M; Butters Terry D
Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling.
Analytical biochemistry 2004;331(2):275-82.
2004: Lachmann Robin H; te Vruchte Danielle; Lloyd-Evans Emyr; Reinkensmeier Gabriele; Sillence Daniel J; Fernandez-Guillen Luisa; Dwek Raymond A; Butters Terry D; Cox Timothy M; Platt Frances M
Treatment with miglustat reverses the lipid-trafficking defect in Niemann-Pick disease type C.
Neurobiology of disease 2004;16(3):654-8.
2004: Andersson Ulrika; Smith David; Jeyakumar Mylvaganam; Butters Terry D; Borja Mario Cortina; Dwek Raymond A; Platt Frances M
Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease.
Neurobiology of disease 2004;16(3):506-15.
2004: Mellor Howard R; Neville David C A; Harvey David J; Platt Frances M; Dwek Raymond A; Butters Terry D
Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
The Biochemical journal 2004;381(Pt 3):867-75.
2004: Mellor Howard R; Neville David C A; Harvey David J; Platt Frances M; Dwek Raymond A; Butters Terry D
Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
The Biochemical journal 2004;381(Pt 3):861-6.
2004: Branza-Nichita Norica; Lazar Catalin; Dwek Raymond A; Zitzmann Nicole
Role of N-glycan trimming in the folding and secretion of the pestivirus protein E(rns).
Biochemical and biophysical research communications 2004;319(2):655-62.
2004: Tekoah Yoram; Ko Kisung; Koprowski Hilary; Harvey David J; Wormald Mark R; Dwek Raymond A; Rudd Pauline M
Controlled glycosylation of therapeutic antibodies in plants.
Archives of biochemistry and biophysics 2004;426(2):266-78.
2004: Mehta Anand S; Gu Baohua; Conyers Bertha; Ouzounov Serguey; Wang Lijuan; Moriarty Robert M; Dwek Raymond A; Block Timothy M
alpha-Galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses.
Antimicrobial agents and chemotherapy 2004;48(6):2085-90.
2004: te Vruchte Danielle; Lloyd-Evans Emyr; Veldman Robert Jan; Neville David C A; Dwek Raymond A; Platt Frances M; van Blitterswijk Wim J; Sillence Dan J
Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.
The Journal of biological chemistry 2004;279(25):26167-75.
2004: Wearsch Pamela A; Jakob Claude A; Vallin Antonio; Dwek Raymond A; Rudd Pauline M; Cresswell Peter
Major histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly status.
The Journal of biological chemistry 2004;279(24):25112-21.
2004: Crispin M D Max; Ritchie Gayle E; Critchley Alison J; Morgan B Paul; Wilson Ian A; Dwek Raymond A; Sim Robert B; Rudd Pauline M
Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure.
FEBS letters 2004;566(1-3):270-4.
2004: García Angel; Prabhakar Sripadi; Brock Chris J; Pearce Andrew C; Dwek Raymond A; Watson Steve P; Hebestreit Holger F; Zitzmann Nicole
Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry.
Proteomics 2004;4(3):656-68.
2004: García Angel; Prabhakar Sripadi; Hughan Sascha; Anderson Tom W; Brock Chris J; Pearce Andrew C; Dwek Raymond A; Watson Steve P; Hebestreit Holger F; Zitzmann Nicole
Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.
Blood 2004;103(6):2088-95.
2004: Lee Hing-Ken; Scanlan Christopher N; Huang Cheng-Yuan; Chang Aileen Y; Calarese Daniel A; Dwek Raymond A; Rudd Pauline M; Burton Dennis R; Wilson Ian A; Wong Chi-Huey
Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody.
Angewandte Chemie (International ed. in English) 2004;43(8):1000-3.
2004: Andersson Ulrika; Reinkensmeier Gabriele; Butters Terry D; Dwek Raymond A; Platt Frances M
Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.
Biochemical pharmacology 2004;67(4):697-705.
2004: Durantel David; Carrouée-Durantel Sandra; Branza-Nichita Norica; Dwek Raymond A; Zitzmann Nicole
Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus.
Antimicrobial agents and chemotherapy 2004;48(2):497-504.
2004: Lukacik P; Roversi P; White J; Esser D; Smith G P; Billington J; Williams P A; Rudd P M; Wormald M R; Harvey D J; Crispin M D M; Radcliffe C M; Dwek R A; Evans D J; Morgan B P; Smith R A G; Lea S M
Complement regulation at the molecular level: the structure of decay-accelerating factor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1279-84.
2004: Petrescu Andrei-J; Milac Adina-L; Petrescu Stefana M; Dwek Raymond A; Wormald Mark R
Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding.
Glycobiology 2004;14(2):103-14.
2004: Elstein D; Hollak C; Aerts J M F G; van Weely S; Maas M; Cox T M; Lachmann R H; Hrebicek M; Platt F M; Butters T D; Dwek R A; Zimran A
Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease.
Journal of inherited metabolic disease 2004;27(6):757-66.
2004: Omtvedt L A; Royle L; Husby G; Sletten K; Radcliffe C; Dwek R A; Rudd P M; Harvey D J
Artefacts formed by addition of urea to N-linked glycans released with peptide-N-glycosidase F for analysis by mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(19):2357-9.
2003: Lazar Catalin; Zitzmann Nicole; Dwek Raymond A; Branza-Nichita Norica
The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions.
Virology 2003;314(2):696-705.
2003: Butler Michael; Quelhas D; Critchley Alison J; Carchon Hubert; Hebestreit Holger F; Hibbert Richard G; Vilarinho Laura; Teles E; Matthijs Gert; Schollen Els; Argibay Pablo; Harvey David J; Dwek Raymond A; Jaeken Jaak; Rudd Pauline M
Detailed glycan analysis of serum glycoproteins of patients with congenital disorders of glycosylation indicates the specific defective glycan processing step and provides an insight into pathogenesis.
Glycobiology 2003;13(9):601-22.
2003: Mellor Howard R; Platt Frances M; Dwek Raymond A; Butters Terry D
Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
The Biochemical journal 2003;374(Pt 2):307-14.
2003: Negroiu Gabriela; Dwek Raymond A; Petrescu Stefana M
The inhibition of early N-glycan processing targets TRP-2 to degradation in B16 melanoma cells.
The Journal of biological chemistry 2003;278(29):27035-42.
2003: Merry Anthony H; Gilbert Robert J C; Shore David A; Royle Louise; Miroshnychenko Olga; Vuong Mai; Wormald Mark R; Harvey David J; Dwek Raymond A; Classon Brendan J; Rudd Pauline M; Davis Simon J
O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.
The Journal of biological chemistry 2003;278(29):27119-28.
2003: Calarese Daniel A; Scanlan Christopher N; Zwick Michael B; Deechongkit Songpon; Mimura Yusuke; Kunert Renate; Zhu Ping; Wormald Mark R; Stanfield Robyn L; Roux Kenneth H; Kelly Jeffery W; Rudd Pauline M; Dwek Raymond A; Katinger Hermann; Burton Dennis R; Wilson Ian A
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science (New York, N.Y.) 2003;300(5628):2065-71.
2003: Ko Kisung; Tekoah Yoram; Rudd Pauline M; Harvey David J; Dwek Raymond A; Spitsin Sergei; Hanlon Cathleen A; Rupprecht Charles; Dietzschold Bernhard; Golovkin Maxim; Koprowski Hilary
Function and glycosylation of plant-derived antiviral monoclonal antibody.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):8013-8.
2003: Peracaula Rosa; Tabarés Glòria; Royle Louise; Harvey David J; Dwek Raymond A; Rudd Pauline M; de Llorens Rafael
Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins.
Glycobiology 2003;13(6):457-70.
2003: Platt Frances M; Jeyakumar Mylvaganam; Andersson Ulrika; Heare Tanya; Dwek Raymond A; Butters Terry D
Substrate reduction therapy in mouse models of the glycosphingolipidoses.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1433):947-54.
2003: Butters Terry D; Mellor Howard R; Narita Keishi; Dwek Raymond A; Platt Frances M
Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1433):927-45.
2003: Steel Laura F; Shumpert Donna; Trotter Michael; Seeholzer Steven H; Evans Alison A; London W Thomas; Dwek Raymond; Block Timothy M
A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.
Proteomics 2003;3(5):601-9.
2003: Pavlovic Davor; Neville David C A; Argaud Olivier; Blumberg Baruch; Dwek Raymond A; Fischer Wolfgang B; Zitzmann Nicole
The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6104-8.
2003: Royle Louise; Roos Anja; Harvey David J; Wormald Mark R; van Gijlswijk-Janssen Daniëlle; Redwan El-Rashdy M; Wilson Ian A; Daha Mohamed R; Dwek Raymond A; Rudd Pauline M
Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems.
The Journal of biological chemistry 2003;278(22):20140-53.
2003: Peracaula Rosa; Royle Louise; Tabares Glòria; Mallorqui-Fernández Goretti; Barrabés Silvia; Harvey David J; Dwek Raymond A; Rudd Pauline M; de Llorens Rafael
Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.
Glycobiology 2003;13(4):227-44.
2003: Jeyakumar M; Thomas R; Elliot-Smith E; Smith D A; van der Spoel A C; d'Azzo A; Perry V Hugh; Butters T D; Dwek R A; Platt F M
Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.
Brain : a journal of neurology 2003;126(Pt 4):974-87.
2003: Kim Soohyun; Hwang Soo Kyung; Dwek Raymond A; Rudd Pauline M; Ahn Yeong Hee; Kim Eun-Hee; Cheong Chaejoon; Kim Seung Il; Park Nam Sook; Lee Sang Mong
Structural determination of the N-glycans of a lepidopteran arylphorin reveals the presence of a monoglucosylated oligosaccharide in the storage protein.
Glycobiology 2003;13(3):147-57.
2003: Svensson Majlis; Frendeus Björn; Butters Terry; Platt Frances; Dwek Raymond; Svanborg Catharina
Glycolipid depletion in antimicrobial therapy.
Molecular microbiology 2003;47(2):453-61.
2003: Petrescu Stefana M; Popescu Costin I; Petrescu Andrei J; Dwek Raymond A
The glycosylation of tyrosinase in melanoma cells and the effect on antigen presentation.
Advances in experimental medicine and biology 2003;535():257-69.
2003: Butters T D; Dwek R A; Platt F M
New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
Advances in experimental medicine and biology 2003;535():219-26.
2003: Scanlan Christopher N; Pantophlet Ralph; Wormald Mark R; Saphire Erica Ollmann; Calarese Daniel; Stanfield Robyn; Wilson Ian A; Katinger Hermann; Dwek Raymond A; Burton Dennis R; Rudd Pauline M
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
Advances in experimental medicine and biology 2003;535():205-18.
2003: Saphire Erica Ollmann; Stanfield Robyn L; Crispin M D Max; Morris Garrett; Zwick Michael B; Pantophlet Ralph A; Parren Paul W H I; Rudd Pauline M; Dwek Raymond A; Burton Dennis R; Wilson Ian A
Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
Advances in experimental medicine and biology 2003;535():55-66.
2003: Butters Terry D; Dwek Raymond A; Platt Frances M
Therapeutic applications of imino sugars in lysosomal storage disorders.
Current topics in medicinal chemistry 2003;3(5):561-74.
2002: Van den Steen Philippe E; Dubois Bénédicte; Nelissen Inge; Rudd Pauline M; Dwek Raymond A; Opdenakker Ghislain
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).
Critical reviews in biochemistry and molecular biology 2002;37(6):375-536.
2002: van der Spoel Aarnoud C; Jeyakumar Mylvaganam; Butters Terry D; Charlton Harry M; Moore Harry D; Dwek Raymond A; Platt Frances M
Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17173-8.
2002: Navazio Lorella; Miuzzo Manuela; Royle Louise; Baldan Barbara; Varotto Serena; Merry Anthony H; Harvey David J; Dwek Raymond A; Rudd Pauline M; Mariani Paola
Monitoring endoplasmic reticulum-to-Golgi traffic of a plant calreticulin by protein glycosylation analysis.
Biochemistry 2002;41(48):14141-9.
2002: Mehta Anand; Conyers Bertha; Tyrrell D L J; Walters Kathie-Anne; Tipples Graham A; Dwek Raymond A; Block Timothy M
Structure-activity relationship of a new class of anti-hepatitis B virus agents.
Antimicrobial agents and chemotherapy 2002;46(12):4004-8.
2002: Sillence Dan J; Puri Vishwajeet; Marks David L; Butters Terry D; Dwek Raymond A; Pagano Richard E; Platt Frances M
Glucosylceramide modulates membrane traffic along the endocytic pathway.
Journal of lipid research 2002;43(11):1837-45.
2002: Radcliffe Catherine M; Diedrich Gundo; Harvey David J; Dwek Raymond A; Cresswell Peter; Rudd Pauline M
Identification of specific glycoforms of major histocompatibility complex class I heavy chains suggests that class I peptide loading is an adaptation of the quality control pathway involving calreticulin and ERp57.
The Journal of biological chemistry 2002;277(48):46415-23.
2002: Rudd Pauline M; Merry Anthony H; Wormald Mark R; Dwek Raymond A
Glycosylation and prion protein.
Current opinion in structural biology 2002;12(5):578-86.
2002: Jeyakumar M; Butters T D; Dwek R A; Platt F M
Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
Neuropathology and applied neurobiology 2002;28(5):343-57.
2002: Mehta Anand; Ouzounov Serguey; Jordan Robert; Simsek Ender; Lu Xuanyong; Moriarty Robert M; Jacob Gary; Dwek Raymond A; Block Timothy M
Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.
Antiviral chemistry & chemotherapy 2002;13(5):299-304.
2002: Ouzounov Serguey; Mehta Anand; Dwek Raymond A; Block Timothy M; Jordan Robert
The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Antiviral research 2002;55(3):425-35.
2002: Jeyakumar Mylvaganam; Smith David; Eliott-Smith Elena; Cortina-Borja Mario; Reinkensmeier Gabriele; Butters Terry D; Lemm Thorsten; Sandhoff Konrad; Perry V Hugh; Dwek Raymond A; Platt Frances M
An inducible mouse model of late onset Tay-Sachs disease.
Neurobiology of disease 2002;10(3):201-10.
2002: Branza-Nichita Norica; Lazar Catalin; Durantel David; Dwek Raymond A; Zitzmann Nicole
Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus.
Biochemical and biophysical research communications 2002;296(2):470-6.
2002: Mellor Howard R; Nolan James; Pickering Lea; Wormald Mark R; Platt Frances M; Dwek Raymond A; Fleet George W J; Butters Terry D
Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.
The Biochemical journal 2002;366(Pt 1):225-33.
2002: Scanlan Christopher N; Pantophlet Ralph; Wormald Mark R; Ollmann Saphire Erica; Stanfield Robyn; Wilson Ian A; Katinger Hermann; Dwek Raymond A; Rudd Pauline M; Burton Dennis R
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
Journal of virology 2002;76(14):7306-21.
2002: Saphire Erica Ollmann; Stanfield Robyn L; Crispin M D Max; Parren Paul W H I; Rudd Pauline M; Dwek Raymond A; Burton Dennis R; Wilson Ian A
Contrasting IgG structures reveal extreme asymmetry and flexibility.
Journal of molecular biology 2002;319(1):9-18.
2002: Costin Gertrude-E; Trif Mihaela; Nichita Norica; Dwek Raymond A; Petrescu Stefana M
pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells.
Biochemical and biophysical research communications 2002;293(3):918-23.
2002: Merry Anthony H; Neville David C A; Royle Louise; Matthews Brian; Harvey David J; Dwek Raymond A; Rudd Pauline M
Recovery of intact 2-aminobenzamide-labeled O-glycans released from glycoproteins by hydrazinolysis.
Analytical biochemistry 2002;304(1):91-9.
2002: Royle Louise; Mattu Taj S; Hart Edmund; Langridge James I; Merry Anthony H; Murphy Neil; Harvey David J; Dwek Raymond A; Rudd Pauline M
An analytical and structural database provides a strategy for sequencing O-glycans from microgram quantities of glycoproteins.
Analytical biochemistry 2002;304(1):70-90.
2002: Wheeler Susan F; Rudd Pauline M; Davis Simon J; Dwek Raymond A; Harvey David J
Comparison of the N-linked glycans from soluble and GPI-anchored CD59 expressed in CHO cells.
Glycobiology 2002;12(4):261-71.
2002: Wu Shu-Fen; Lee Chyan-Jang; Liao Ching-Len; Dwek Raymond A; Zitzmann Nicole; Lin Yi-Ling
Antiviral effects of an iminosugar derivative on flavivirus infections.
Journal of virology 2002;76(8):3596-604.
2002: Jordan Robert; Nikolaeva Olga V; Wang Lijuan; Conyers Bertha; Mehta Anand; Dwek Raymond A; Block Timothy M
Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions.
Virology 2002;295(1):10-9.
2002: Magnadóttir Bergljót; Crispin Max; Royle Louise; Colominas Cristina; Harvey David J; Dwek Raymond A; Rudd Pauline M
The carbohydrate moiety of serum IgM from Atlantic cod (Gadus morhua L.).
Fish & shellfish immunology 2002;12(3):209-27.
2002: O'Neill Eric E; Brock Chris J; von Kriegsheim Alexander F; Pearce Andrew C; Dwek Raymond A; Watson Steve P; Hebestreit Holger F
Towards complete analysis of the platelet proteome.
Proteomics 2002;2(3):288-305.
2002: Harvey David J; Mattu Taj S; Wormald Mark R; Royle Louise; Dwek Raymond A; Rudd Pauline M
"Internal residue loss": rearrangements occurring during the fragmentation of carbohydrates derivatized at the reducing terminus.
Analytical chemistry 2002;74(4):734-40.
2002: Wormald Mark R; Petrescu Andrei J; Pao Ya-Lan; Glithero Ann; Elliott Tim; Dwek Raymond A
Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling.
Chemical reviews 2002;102(2):371-86.
2002: Ritchie Gayle E; Moffatt Beryl E; Sim Robert B; Morgan B Paul; Dwek Raymond A; Rudd Pauline M
Glycosylation and the complement system.
Chemical reviews 2002;102(2):305-20-19.
2002: Garner Brett; Mellor Howard R; Butters Terry D; Dwek Raymond A; Platt Frances M
Modulation of THP-1 macrophage and cholesterol-loaded foam cell apolipoprotein E levels by glycosphingolipids.
Biochemical and biophysical research communications 2002;290(5):1361-7.
2002: Dwek Raymond A; Butters Terry D; Platt Frances M; Zitzmann Nicole
Targeting glycosylation as a therapeutic approach.
Nature reviews. Drug discovery 2002;1(1):65-75.
2002: von Der Ohe Maren; Wheeler Susan F; Wuhrer Manfred; Harvey David J; Liedtke Steffen; Mühlenhoff Martina; Gerardy-Schahn Rita; Geyer Hildegard; Dwek Raymond A; Geyer Rudolf; Wing David R; Schachner Melitta
Localization and characterization of polysialic acid-containing N-linked glycans from bovine NCAM.
Glycobiology 2002;12(1):47-63.
2001: Wing D R; Garner B; Hunnam V; Reinkensmeier G; Andersson U; Harvey D J; Dwek R A; Platt F M; Butters T D
High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide.
Analytical biochemistry 2001;298(2):207-17.
2001: Lu X; Lu Y; Geschwindt R; Dwek R A; Block T M
Hepatitis B virus MHBs antigen is selectively sensitive to glucosidase-mediated processing in the endoplasmic reticulum.
DNA and cell biology 2001;20(10):647-56.
2001: Durantel D; Branza-Nichita N; Carrouée-Durantel S; Butters T D; Dwek R A; Zitzmann N
Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus.
Journal of virology 2001;75(19):8987-98.
2001: Saphire E O; Parren P W; Pantophlet R; Zwick M B; Morris G M; Rudd P M; Dwek R A; Stanfield R L; Burton D R; Wilson I A
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science (New York, N.Y.) 2001;293(5532):1155-9.
2001: Zamze S; Wing D R; Wormald M R; Hunter A P; Dwek R A; Harvey D J
A family of novel, acidic N-glycans in Bowes melanoma tissue plasminogen activator have L2/HNK-1-bearing antennae, many with sulfation of the fucosylated chitobiose core.
European journal of biochemistry / FEBS 2001;268(14):4063-78.
2001: Mehta A; Carrouée S; Conyers B; Jordan R; Butters T; Dwek R A; Block T M
Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
Hepatology (Baltimore, Md.) 2001;33(6):1488-95.
2001: Platt F M; Jeyakumar M; Andersson U; Priestman D A; Dwek R A; Butters T D; Cox T M; Lachmann R H; Hollak C; Aerts J M; Van Weely S; Hrebícek M; Moyses C; Gow I; Elstein D; Zimran A
Inhibition of substrate synthesis as a strategy for glycolipid lysosomal storage disease therapy.
Journal of inherited metabolic disease 2001;24(2):275-90.
2001: Rudd P M; Wormald M R; Wing D R; Prusiner S B; Dwek R A
Prion glycoprotein: structure, dynamics, and roles for the sugars.
Biochemistry 2001;40(13):3759-66.
2001: Branza-Nichita N; Durantel D; Carrouée-Durantel S; Dwek R A; Zitzmann N
Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers.
Journal of virology 2001;75(8):3527-36.
2001: Rudd P M; Elliott T; Cresswell P; Wilson I A; Dwek R A
Glycosylation and the immune system.
Science (New York, N.Y.) 2001;291(5512):2370-6.
2001: Svensson M; Platt F; Frendeus B; Butters T; Dwek R; Svanborg C
Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection.
The Journal of infectious diseases 2001;183 Suppl 1():S70-3.
2001: Rudd P M; Colominas C; Royle L; Murphy N; Hart E; Merry A H; Hebestreit H F; Dwek R A
A high-performance liquid chromatography based strategy for rapid, sensitive sequencing of N-linked oligosaccharide modifications to proteins in sodium dodecyl sulphate polyacrylamide electrophoresis gel bands.
Proteomics 2001;1(2):285-94.
2001: Mehta A; Lu X; Block T; Willis A; Dwek R; Tennant B; Blumberg B
Synovial stimulatory protein fragments copurify with woodchuck hepatitis virus: implications for the etiology of arthritis in chronic hepatitis B virus infection.
Arthritis and rheumatism 2001;44(2):486-7.
2001: Jeyakumar M; Norflus F; Tifft C J; Cortina-Borja M; Butters T D; Proia R L; Perry V H; Dwek R A; Platt F M
Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation.
Blood 2001;97(1):327-9.
2001: Steel L F; Mattu T S; Mehta A; Hebestreit H; Dwek R; Evans A A; London W T; Block T
A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma.
Disease markers 2001;17(3):179-89.
2000: Mattu T S; Royle L; Langridge J; Wormald M R; Van den Steen P E; Van Damme J; Opdenakker G; Harvey D J; Dwek R A; Rudd P M
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
Biochemistry 2000;39(51):15695-704.
2000: Priestman D A; Platt F M; Dwek R A; Butters T D
Imino sugar therapy for type 1 Gaucher disease.
Glycobiology 2000;10(11):iv-vi.
2000: Negroiu G; Dwek R A; Petrescu S M
Folding and maturation of tyrosinase-related protein-1 are regulated by the post-translational formation of disulfide bonds and by N-glycan processing.
The Journal of biological chemistry 2000;275(41):32200-7.
2000: Mellor H R; Adam A; Platt F M; Dwek R A; Butters T D
High-performance cation-exchange chromatography and pulsed amperometric detection for the separation, detection, and quantitation of N-alkylated imino sugars in biological samples.
Analytical biochemistry 2000;284(1):136-42.
2000: Petrescu S M; Branza-Nichita N; Negroiu G; Petrescu A J; Dwek R A
Tyrosinase and glycoprotein folding: roles of chaperones that recognize glycans.
Biochemistry 2000;39(18):5229-37.
2000: Cox T; Lachmann R; Hollak C; Aerts J; van Weely S; Hrebícek M; Platt F; Butters T; Dwek R; Moyses C; Gow I; Elstein D; Zimran A
Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.
Lancet 2000;355(9214):1481-5.
2000: Andersson U; Butters T D; Dwek R A; Platt F M
N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo.
Biochemical pharmacology 2000;59(7):821-9.
2000: Branza-Nichita N; Negroiu G; Petrescu A J; Garman E F; Platt F M; Wormald M R; Dwek R A; Petrescu S M
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
The Journal of biological chemistry 2000;275(11):8169-75.
2000: Rudd P M; Downing A K; Cadene M; Harvey D J; Wormald M R; Weir I; Dwek R A; Rifkin D B; Gleizes P E
Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells.
Biochemistry 2000;39(7):1596-603.
1999: Negroiu G; Branza-Nichita N; Petrescu A J; Dwek R A; Petrescu S M
Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells.
The Biochemical journal 1999;344 Pt 3():659-65.
1999: Martínez-Pomares L; Crocker P R; Da Silva R; Holmes N; Colominas C; Rudd P; Dwek R; Gordon S
Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor.
The Journal of biological chemistry 1999;274(49):35211-8.
1999: Devasahayam M; Catalino P D; Rudd P M; Dwek R A; Barclay A N
The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor.
Glycobiology 1999;9(12):1381-7.
1999: Negroiu G; Branza-Nichita N; Costin G E; Titu H; Petrescu A J; Dwek R A; Petrescu S M
Investigation of the intracellular transport of tyrosinase and tyrosinase related protein (TRP)-1. The effect of endoplasmic reticulum (ER)-glucosidases inhibition.
Cellular and molecular biology (Noisy-le-Grand, France) 1999;45(7):1001-10.
1999: Rudd P M; Endo T; Colominas C; Groth D; Wheeler S F; Harvey D J; Wormald M R; Serban H; Prusiner S B; Kobata A; Dwek R A
Glycosylation differences between the normal and pathogenic prion protein isoforms.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13044-9.
1999: Rudd P M; Wormald M R; Stanfield R L; Huang M; Mattsson N; Speir J A; DiGennaro J A; Fetrow J S; Dwek R A; Wilson I A
Roles for glycosylation of cell surface receptors involved in cellular immune recognition.
Journal of molecular biology 1999;293(2):351-66.
1999: Rudd P M; Mattu T S; Masure S; Bratt T; Van den Steen P E; Wormald M R; Küster B; Harvey D J; Borregaard N; Van Damme J; Dwek R A; Opdenakker G
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
Biochemistry 1999;38(42):13937-50.
1999: Zitzmann N; Mehta A S; Carrouée S; Butters T D; Platt F M; McCauley J; Blumberg B S; Dwek R A; Block T M
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11878-82.
1999: Clark R A; Küster B; Benallal M; Anner B M; Dwek R A; Harvey D J; Wing D R
Characterisation of tissue-specific oligosaccharides from rat brain and kidney membrane preparations enriched in Na+,K+-ATPase.
Glycoconjugate journal 1999;16(8):437-56.
1999: Branza-Nichita N; Petrescu A J; Dwek R A; Wormald M R; Platt F M; Petrescu S M
Tyrosinase folding and copper loading in vivo: a crucial role for calnexin and alpha-glucosidase II.
Biochemical and biophysical research communications 1999;261(3):720-5.
1999: Zamze S; Harvey D J; Pesheva P; Mattu T S; Schachner M; Dwek R A; Wing D R
Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans.
Glycobiology 1999;9(8):823-31.
1999: Wormald M R; Dwek R A
Glycoproteins: glycan presentation and protein-fold stability.
Structure (London, England : 1993) 1999;7(7):R155-60.
1999: Jeyakumar M; Butters T D; Cortina-Borja M; Hunnam V; Proia R L; Perry V H; Dwek R A; Platt F M
Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6388-93.
1999: Rudd P M; Wormald M R; Harvey D J; Devasahayam M; McAlister M S; Brown M H; Davis S J; Barclay A N; Dwek R A
Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.
Glycobiology 1999;9(5):443-58.
1999: Petrescu A J; Petrescu S M; Dwek R A; Wormald M R
A statistical analysis of N- and O-glycan linkage conformations from crystallographic data.
Glycobiology 1999;9(4):343-52.
1999: Glithero A; Tormo J; Haurum J S; Arsequell G; Valencia G; Edwards J; Springer S; Townsend A; Pao Y L; Wormald M; Dwek R A; Jones E Y; Elliott T
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
Immunity 1999;10(1):63-74.
1999: Rudd P M; Mattu T S; Zitzmann N; Mehta A; Colominas C; Hart E; Opdenakker G; Dwek R A
Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans.
Biotechnology & genetic engineering reviews 1999;16():1-21.
1998: Guile G R; Harvey D J; O'Donnell N; Powell A K; Hunter A P; Zamze S; Fernandes D L; Dwek R A; Wing D R
Identification of highly fucosylated N-linked oligosaccharides from the human parotid gland.
European journal of biochemistry / FEBS 1998;258(2):623-56.
1998: Woods R J; Pathiaseril A; Wormald M R; Edge C J; Dwek R A
The high degree of internal flexibility observed for an oligomannose oligosaccharide does not alter the overall topology of the molecule.
European journal of biochemistry / FEBS 1998;258(2):372-86.
1998: Zamze S; Harvey D J; Chen Y J; Guile G R; Dwek R A; Wing D R
Sialylated N-glycans in adult rat brain tissue--a widespread distribution of disialylated antennae in complex and hybrid structures.
European journal of biochemistry / FEBS 1998;258(1):243-70.
1998: Van den Steen P; Rudd P M; Proost P; Martens E; Paemen L; Küster B; van Damme J; Dwek R A; Opdenakker G
Oligosaccharides of recombinant mouse gelatinase B variants.
Biochimica et biophysica acta 1998;1425(3):587-98.
1998: McAlister M S; Brown M H; Willis A C; Rudd P M; Harvey D J; Aplin R; Shotton D M; Dwek R A; Barclay A N; Driscoll P C
Structural analysis of the CD5 antigen--expression, disulphide bond analysis and physical characterisation of CD5 scavenger receptor superfamily domain 1.
European journal of biochemistry / FEBS 1998;257(1):131-41.
1998: Küster B; Hunter A P; Wheeler S F; Dwek R A; Harvey D J
Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulphate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein.
Electrophoresis 1998;19(11):1950-9.
1998: Rudd P M; Wormald M R; Dwek R A
Glycosylation and the immune system.
Journal of protein chemistry 1998;17(6):519.
1998: Mehta A; Zitzmann N; Rudd P M; Block T M; Dwek R A
Alpha-glucosidase inhibitors as potential broad based anti-viral agents.
FEBS letters 1998;430(1-2):17-22.
1998: Clark R A; Gurd J W; Bissoon N; Tricaud N; Molnar E; Zamze S E; Dwek R A; McIlhinney R A; Wing D R
Identification of lectin-purified neural glycoproteins, GPs 180, 116, and 110, with NMDA and AMPA receptor subunits: conservation of glycosylation at the synapse.
Journal of neurochemistry 1998;70(6):2594-605.
1998: Block T M; Lu X; Mehta A S; Blumberg B S; Tennant B; Ebling M; Korba B; Lansky D M; Jacob G S; Dwek R A
Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking.
Nature medicine 1998;4(5):610-4.
1998: Chen Y J; Wing D R; Guile G R; Dwek R A; Harvey D J; Zamze S
Neutral N-glycans in adult rat brain tissue--complete characterisation reveals fucosylated hybrid and complex structures.
European journal of biochemistry / FEBS 1998;251(3):691-703.
1998: Mattu T S; Pleass R J; Willis A C; Kilian M; Wormald M R; Lellouch A C; Rudd P M; Woof J M; Dwek R A
The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions.
The Journal of biological chemistry 1998;273(4):2260-72.
1998: Dwek R A
Biological importance of glycosylation.
Developments in biological standardization 1998;96():43-7.
1998: Van den Steen P; Rudd P M; Dwek R A; Opdenakker G
Concepts and principles of O-linked glycosylation.
Critical reviews in biochemistry and molecular biology 1998;33(3):151-208.
1998: Block T M; Lu X; Mehta A; Park J; Blumberg B S; Dwek R
Role of glycan processing in hepatitis B virus envelope protein trafficking.
Advances in experimental medicine and biology 1998;435():207-16.
1998: Mehta A; Block T M; Dwek R A
The role of N-linked glycosylation in the secretion of hepatitis B virus.
Advances in experimental medicine and biology 1998;435():195-205.
1998: Rudd P M; Morgan B P; Wormald M R; Harvey D J; van den Berg C W; Davis S J; Ferguson M A; Dwek R A
The glycosylation of the complement regulatory protein, human erythrocyte CD59.
Advances in experimental medicine and biology 1998;435():153-62.
1998: Van den Steen P; Rudd P M; Dwek R A; Van Damme J; Opdenakker G
Cytokine and protease glycosylation as a regulatory mechanism in inflammation and autoimmunity.
Advances in experimental medicine and biology 1998;435():133-43.
1997: Mehta A; Rudd P M; Block T M; Dwek R A
A strategy for anti-viral intervention: the use of alpha-glucosidase inhibitors to prevent chaperone-mediated folding of viral envelope glycoproteins.
Biochemical Society transactions 1997;25(4):1188-93.
1997: Rudd P M; Morgan B P; Wormald M R; Harvey D J; van den Berg C W; Davis S J; Ferguson M A; Dwek R A
Roles for glycosylation in the anti-inflammatory molecule CD59.
Biochemical Society transactions 1997;25(4):1177-84.
1997: Platt F M; Reinkensmeier G; Dwek R A; Butters T D
Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin.
The Journal of biological chemistry 1997;272(31):19365-72.
1997: Petrescu A J; Butters T D; Reinkensmeier G; Petrescu S; Platt F M; Dwek R A; Wormald M R
The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding.
The EMBO journal 1997;16(14):4302-10.
1997: Küster B; Wheeler S F; Hunter A P; Dwek R A; Harvey D J
Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance liquid chromatography.
Analytical biochemistry 1997;250(1):82-101.
1997: Rudd P M; Guile G R; Küster B; Harvey D J; Opdenakker G; Dwek R A
Oligosaccharide sequencing technology.
Nature 1997;388(6638):205-7.
1997: Petrescu S M; Petrescu A J; Titu H N; Dwek R A; Platt F M
Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome.
The Journal of biological chemistry 1997;272(25):15796-803.
1997: Platt F M; Neises G R; Reinkensmeier G; Townsend M J; Perry V H; Proia R L; Winchester B; Dwek R A; Butters T D
Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin.
Science (New York, N.Y.) 1997;276(5311):428-31.
1997: Lu X; Mehta A; Dadmarz M; Dwek R; Blumberg B S; Block T M
Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2380-5.
1997: Rudd P M; Morgan B P; Wormald M R; Harvey D J; van den Berg C W; Davis S J; Ferguson M A; Dwek R A
The glycosylation of the complement regulatory protein, human erythrocyte CD59.
The Journal of biological chemistry 1997;272(11):7229-44.
1997: Mehta A; Lu X; Block T M; Blumberg B S; Dwek R A
Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1822-7.
1997: Wormald M R; Rudd P M; Harvey D J; Chang S C; Scragg I G; Dwek R A
Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides.
Biochemistry 1997;36(6):1370-80.
1997: Mir-Shekari S Y; Ashford D A; Harvey D J; Dwek R A; Schulze I T
The glycosylation of the influenza A virus hemagglutinin by mammalian cells. A site-specific study.
The Journal of biological chemistry 1997;272(7):4027-36.
1997: Rudd P M; Dwek R A
Glycosylation: heterogeneity and the 3D structure of proteins.
Critical reviews in biochemistry and molecular biology 1997;32(1):1-100.
1996: Iourin O; Mattu T S; Mian N; Keir G; Winchester B; Dwek R A; Rudd P M
The identification of abnormal glycoforms of serum transferrin in carbohydrate deficient glycoprotein syndrome type I by capillary zone electrophoresis.
Glycoconjugate journal 1996;13(6):1031-42.
1996: Fischer P B; Karlsson G B; Dwek R A; Platt F M
N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure.
Journal of virology 1996;70(10):7153-60.
1996: Fischer P B; Karlsson G B; Butters T D; Dwek R A; Platt F M
N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120.
Journal of virology 1996;70(10):7143-52.
1996: Guile G R; Rudd P M; Wing D R; Prime S B; Dwek R A
A rapid high-resolution high-performance liquid chromatographic method for separating glycan mixtures and analyzing oligosaccharide profiles.
Analytical biochemistry 1996;240(2):210-26.
1996: Jaques A J; Opdenakker G; Rademacher T W; Dwek R A; Zamze S E
The glycosylation of Bowes melanoma tissue plasminogen activator: lectin mapping, reaction with anti-L2/HNK-1 antibodies and the presence of sulphated/glucuronic acid containing glycans.
The Biochemical journal 1996;316 ( Pt 2)():427-37.
1996: Youings A; Chang S C; Dwek R A; Scragg I G
Site-specific glycosylation of human immunoglobulin G is altered in four rheumatoid arthritis patients.
The Biochemical journal 1996;314 ( Pt 2)():621-30.
1996: Pao Y L; Wormarld M R; Dwek R A; Lellouch A C
Effect of serine O-glycosylation on cis-trans proline isomerization.
Biochemical and biophysical research communications 1996;219(1):157-62.
1995: Haurum J S; Tan L; Arsequell G; Frodsham P; Lellouch A C; Moss P A; Dwek R A; McMichael A J; Elliott T
Peptide anchor residue glycosylation: effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition.
European journal of immunology 1995;25(12):3270-6.
1995: Dwek R A; Lellouch A C; Wormald M R
Glycobiology: 'the function of sugar in the IgG molecule'.
Journal of anatomy 1995;187 ( Pt 2)():279-92.
1995: Dwek R A
Glycobiology: more functions for oligosaccharides.
Science (New York, N.Y.) 1995;269(5228):1234-5.
1995: Fischer P B; Collin M; Karlsson G B; James W; Butters T D; Davis S J; Gordon S; Dwek R A; Platt F M
The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.
Journal of virology 1995;69(9):5791-7.
1995: Rudd P M; Woods R J; Wormald M R; Opdenakker G; Downing A K; Campbell I D; Dwek R A
The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.
Biochimica et biophysica acta 1995;1248(1):1-10.
1995: Opdenakker G; Rudd P M; Wormald M; Dwek R A; Van Damme J
Cells regulate the activities of cytokines by glycosylation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(5):453-7.
1995: Malhotra R; Wormald M R; Rudd P M; Fischer P B; Dwek R A; Sim R B
Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein.
Nature medicine 1995;1(3):237-43.
1995: Mori K; Dwek R A; Downing A K; Opdenakker G; Rudd P M
The activation of type 1 and type 2 plasminogen by type I and type II tissue plasminogen activator.
The Journal of biological chemistry 1995;270(7):3261-7.
1995: Dwek R A
Glycobiology: "towards understanding the function of sugars".
Biochemical Society transactions 1995;23(1):1-25.
1995: Davis S J; Davies E A; Barclay A N; Daenke S; Bodian D L; Jones E Y; Stuart D I; Butters T D; Dwek R A; van der Merwe P A
Ligand binding by the immunoglobulin superfamily recognition molecule CD2 is glycosylation-independent.
The Journal of biological chemistry 1995;270(1):369-75.
1995: Rudd P; Fortune F; Lehner T; Parekh R; Patel T; Wormald M; Malhotra R; Sim R; Dwek R
Lectin-carbohydrate interactions in disease. T-cell recognition of IgA and IgD; mannose binding protein recognition of IgG0.
Advances in experimental medicine and biology 1995;376():147-52.
1994: Platt F M; Neises G R; Karlsson G B; Dwek R A; Butters T D
N-butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing.
The Journal of biological chemistry 1994;269(43):27108-14.
1994: Guile G R; Wong S Y; Dwek R A
Analytical and preparative separation of anionic oligosaccharides by weak anion-exchange high-performance liquid chromatography on an inert polymer column.
Analytical biochemistry 1994;222(1):231-5.
1994: Rudd P M; Fortune F; Patel T; Parekh R B; Dwek R A; Lehner T
A human T-cell receptor recognizes 'O'-linked sugars from the hinge region of human IgA1 and IgD.
Immunology 1994;83(1):99-106.
1994: Haurum J S; Arsequell G; Lellouch A C; Wong S Y; Dwek R A; McMichael A J; Elliott T
Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.
The Journal of experimental medicine 1994;180(2):739-44.
1994: Woods R J; Edge C J; Dwek R A
Protein surface oligosaccharides and protein function.
Nature structural biology 1994;1(8):499-501.
1994: Rademacher T W; Williams P; Dwek R A
Agalactosyl glycoforms of IgG autoantibodies are pathogenic.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6123-7.
1994: Wong S Y; Guile G R; Dwek R A; Arsequell G
Synthetic glycosylation of proteins using N-(beta-saccharide) iodoacetamides: applications in site-specific glycosylation and solid-phase enzymic oligosaccharide synthesis.
The Biochemical journal 1994;300 ( Pt 3)():843-50.
1994: Field M C; Amatayakul-Chantler S; Rademacher T W; Rudd P M; Dwek R A
Structural analysis of the N-glycans from human immunoglobulin A1: comparison of normal human serum immunoglobulin A1 with that isolated from patients with rheumatoid arthritis.
The Biochemical journal 1994;299 ( Pt 1)():261-75.
1994: Block T M; Lu X; Platt F M; Foster G R; Gerlich W H; Blumberg B S; Dwek R A
Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2235-9.
1994: Platt F M; Neises G R; Dwek R A; Butters T D
N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
The Journal of biological chemistry 1994;269(11):8362-5.
1994: Arkwright P D; Rademacher T W; Boutignon F; Dwek R A; Redman C W
Suppression of allogeneic reactivity in vitro by the syncytiotrophoblast membrane glycocalyx of the human term placenta is carbohydrate dependent.
Glycobiology 1994;4(1):39-47.
1994: Rudd P M; Joao H C; Coghill E; Fiten P; Saunders M R; Opdenakker G; Dwek R A
Glycoforms modify the dynamic stability and functional activity of an enzyme.
Biochemistry 1994;33(1):17-22.
1994: Arsequell G; Dwek R A; Wong S Y
9-Fluorenylmethoxycarbonyl (Fmoc)-glycine coupling of saccharide beta-glycosylamines for the fractionation of oligosaccharides and the formation of neoglycoconjugates.
Analytical biochemistry 1994;216(1):165-70.
1993: Wong S Y; Manger I D; Guile G R; Rademacher T W; Dwek R A
Analysis of carbohydrate-protein interactions with synthetic N-linked neoglycoconjugate probes.
The Biochemical journal 1993;296 ( Pt 3)():817-25.
1993: Joao H C; Dwek R A
Effects of glycosylation on protein structure and dynamics in ribonuclease B and some of its individual glycoforms.
European journal of biochemistry / FEBS 1993;218(1):239-44.
1993: Opdenakker G; Rudd P M; Ponting C P; Dwek R A
Concepts and principles of glycobiology.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(14):1330-7.
1993: Dwek R A; Ashford D A; Edge C J; Parekh R B; Rademacher T W; Wing D R; Barclay A N; Davis S J; Williams A F
Glycosylation of CD4 and Thy-1.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):43-50.
1993: Williams A F; Parekh R B; Wing D R; Willis A C; Barclay A N; Dalchau R; Fabre J W; Dwek R A; Rademacher T W
Comparative analysis of the N-glycans of rat, mouse and human Thy-1. Site-specific oligosaccharide patterns of neural Thy-1, a member of the immunoglobulin superfamily.
Glycobiology 1993;3(4):339-48.
1993: Arkwright P D; Rademacher T W; Dwek R A; Redman C W
Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles.
The Journal of clinical investigation 1993;91(6):2744-53.
1993: Wong S Y; Guile G R; Rademacher T W; Dwek R A
Synthetic glycosylation of peptides using unprotected saccharide beta-glycosylamines.
Glycoconjugate journal 1993;10(3):227-34.
1993: Amatayakul-Chantler S; Dwek R A; Tennent G A; Pepys M B; Rademacher T W
Molecular characterization of Limulus polyphemus C-reactive protein. II. Asparagine-linked oligosaccharides.
European journal of biochemistry / FEBS 1993;214(1):99-110.
1993: Ashford D A; Alafi C D; Gamble V M; Mackay D J; Rademacher T W; Williams P J; Dwek R A; Barclay A N; Davis S J; Somoza C
Site-specific glycosylation of recombinant rat and human soluble CD4 variants expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1993;268(5):3260-7.
1993: Karlsson G B; Butters T D; Dwek R A; Platt F M
Effects of the imino sugar N-butyldeoxynojirimycin on the N-glycosylation of recombinant gp120.
The Journal of biological chemistry 1993;268(1):570-6.
1993: Dwek R A; Edge C J; Harvey D J; Wormald M R; Parekh R B
Analysis of glycoprotein-associated oligosaccharides.
Annual review of biochemistry 1993;62():65-100.
1992: Wing D R; Rademacher T W; Field M C; Dwek R A; Schmitz B; Thor G; Schachner M
Use of large-scale hydrazinolysis in the preparation of N-linked oligosaccharide libraries: application to brain tissue.
Glycoconjugate journal 1992;9(6):293-301.
1992: Manger I D; Wong S Y; Rademacher T W; Dwek R A
Synthesis of 1-N-glycyl beta-oligosaccharide derivatives. Reactivity of Lens culinaris lectin with a fluorescent labeled streptavidin pseudoglycoprotein and immobilized neoglycolipid.
Biochemistry 1992;31(44):10733-40.
1992: Manger I D; Rademacher T W; Dwek R A
1-N-glycyl beta-oligosaccharide derivatives as stable intermediates for the formation of glycoconjugate probes.
Biochemistry 1992;31(44):10724-32.
1992: Joao H C; Scragg I G; Dwek R A
Effects of glycosylation on protein conformation and amide proton exchange rates in RNase B.
FEBS letters 1992;307(3):343-6.
1992: Edge C J; Rademacher T W; Wormald M R; Parekh R B; Butters T D; Wing D R; Dwek R A
Fast sequencing of oligosaccharides: the reagent-array analysis method.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6338-42.
1992: Wing D R; Rademacher T W; Schmitz B; Schachner M; Dwek R A
Comparative glycosylation in neural adhesion molecules.
Biochemical Society transactions 1992;20(2):386-90.
1992: Rudd P M; Scragg I G; Coghill E; Dwek R A
Separation and analysis of the glycoform populations of ribonuclease B using capillary electrophoresis.
Glycoconjugate journal 1992;9(2):86-91.
1992: Field M C; Wing D R; Dwek R A; Rademacher T W; Schmitz B; Bollensen E; Schachner M
Detection of multisulphated N-linked glycans in the L2/HNK-1 carbohydrate epitope expressing neural adhesion molecule P0.
Journal of neurochemistry 1992;58(3):993-1000.
1991: Sumar N; Colaço C B; Bodman K B; Parekh R; Williams P; Dwek R; Rademacher T; Isenberg D A; Soltys A; Hay F C
Abnormalities in the glycosylation of IgG in spouses of patients with rheumatoid arthritis. A family study.
Journal of autoimmunity 1991;4(6):907-14.
1991: Wormald M R; Edge C J; Dwek R A
The solution conformation of the Le chi group.
Biochemical and biophysical research communications 1991;180(3):1214-21.
1991: Arkwright P D; Redman C W; Williams P J; Dwek R A; Rademacher T W
Syncytiotrophoblast membrane protein glycosylation patterns in normal human pregnancy and changes with gestational age and parturition.
Placenta 1991;12(6):637-51.
1991: Zamze S E; Ashford D A; Wooten E W; Rademacher T W; Dwek R A
Structural characterization of the asparagine-linked oligosaccharides from Trypanosoma brucei type II and type III variant surface glycoproteins.
The Journal of biological chemistry 1991;266(30):20244-61.
1991: Williams P J; Wormald M R; Dwek R A; Rademacher T W; Parker G F; Roberts D R
Characterisation of oligosaccharides from Drosophila melanogaster glycoproteins.
Biochimica et biophysica acta 1991;1075(2):146-53.
1991: Ashford D A; Dwek R A; Rademacher T W; Lis H; Sharon N
The glycosylation of glycoprotein lectins. Intra- and inter-genus variation in N-linked oligosaccharide expression.
Carbohydrate research 1991;213():215-27.
1991: Wormald M R; Wooten E W; Bazzo R; Edge C J; Feinstein A; Rademacher T W; Dwek R A
The conformational effects of N-glycosylation on the tailpiece from serum IgM.
European journal of biochemistry / FEBS 1991;198(1):131-9.
1990: Scudder P; Neville D C; Butters T D; Fleet G W; Dwek R A; Rademacher T W; Jacob G S
The isolation by ligand affinity chromatography of a novel form of alpha-L-fucosidase from almond.
The Journal of biological chemistry 1990;265(27):16472-7.
1990: Perkins S J; Smith K F; Amatayakul S; Ashford D; Rademacher T W; Dwek R A; Lachmann P J; Harrison R A
Two-domain structure of the native and reactive centre cleaved forms of C1 inhibitor of human complement by neutron scattering.
Journal of molecular biology 1990;214(3):751-63.
1990: Wooten E W; Edge C J; Bazzo R; Dwek R A; Rademacher T W
Uncertainties in structural determinations of oligosaccharide conformation, using measurements of nuclear Overhauser effects.
Carbohydrate research 1990;203(1):13-7.
1990: Olafson R W; Thomas J R; Ferguson M A; Dwek R A; Chaudhuri M; Chang K P; Rademacher T W
Structures of the N-linked oligosaccharides of Gp63, the major surface glycoprotein, from Leishmania mexicana amazonensis.
The Journal of biological chemistry 1990;265(21):12240-7.
1990: Sumar N; Bodman K B; Rademacher T W; Dwek R A; Williams P; Parekh R B; Edge J; Rook G A; Isenberg D A; Hay F C
Analysis of glycosylation changes in IgG using lectins.
Journal of immunological methods 1990;131(1):127-36.
1990: Thomas J R; Dwek R A; Rademacher T W
Structure, biosynthesis, and function of glycosylphosphatidylinositols.
Biochemistry 1990;29(23):5413-22.
1990: Edge C J; Singh U C; Bazzo R; Taylor G L; Dwek R A; Rademacher T W
500-picosecond molecular dynamics in water of the Man alpha 1----2Man alpha glycosidic linkage present in Asn-linked oligomannose-type structures on glycoproteins.
Biochemistry 1990;29(8):1971-4.
1990: Zamze S E; Wooten E W; Ashford D A; Ferguson M A; Dwek R A; Rademacher T W
Characterisation of the asparagine-linked oligosaccharides from Trypanosoma brucei type-I variant surface glycoproteins.
European journal of biochemistry / FEBS 1990;187(3):657-63.
1990: Wooten E W; Bazzo R; Edge C J; Zamze S; Dwek R A; Rademacher T W
Primary sequence dependence of conformation in oligomannose oligosaccharides.
European biophysics journal : EBJ 1990;18(3):139-48.
1989: Field M C; Dwek R A; Edge C J; Rademacher T W
O-linked oligosaccharides from human serum immunoglobulin A1.
Biochemical Society transactions 1989;17(6):1034-5.
1989: Parekh R B; Dwek R A; Rudd P M; Thomas J R; Rademacher T W; Warren T; Wun T C; Hebert B; Reitz B; Palmier M
N-glycosylation and in vitro enzymatic activity of human recombinant tissue plasminogen activator expressed in Chinese hamster ovary cells and a murine cell line.
Biochemistry 1989;28(19):7670-9.
1989: Wittwer A J; Howard S C; Carr L S; Harakas N K; Feder J; Parekh R B; Rudd P M; Dwek R A; Rademacher T W
Effects of N-glycosylation on in vitro activity of Bowes melanoma and human colon fibroblast derived tissue plasminogen activator.
Biochemistry 1989;28(19):7662-9.
1989: Parekh R B; Dwek R A; Thomas J R; Opdenakker G; Rademacher T W; Wittwer A J; Howard S C; Nelson R; Siegel N R; Jennings M G
Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator.
Biochemistry 1989;28(19):7644-62.
1989: Homans S W; Edge C J; Ferguson M A; Dwek R A; Rademacher T W
Solution structure of the glycosylphosphatidylinositol membrane anchor glycan of Trypanosoma brucei variant surface glycoprotein.
Biochemistry 1989;28(7):2881-7.
1989: Parekh R; Isenberg D; Rook G; Roitt I; Dwek R; Rademacher T
A comparative analysis of disease-associated changes in the galactosylation of serum IgG.
Journal of autoimmunity 1989;2(2):101-14.
1989: Axford J S; Bodman K; Hay F C; Isenberg D A; Lydyard P M; Mackenzie L; Roitt I M; Sumar N; Rook G; Dwek R A
Comment on the article by Tomana et al.
Arthritis and rheumatism 1989;32(2):235-6.
1989: Rademacher T W; Dwek R A
The role of oligosaccharides in modifying protein function.
Ciba Foundation symposium 1989;145():241-55; discussion 255-6.
1988: Karpas A; Fleet G W; Dwek R A; Petursson S; Namgoong S K; Ramsden N G; Jacob G S; Rademacher T W
Aminosugar derivatives as potential anti-human immunodeficiency virus agents.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9229-33.
1988: Zamze S E; Ferguson M A; Collins R; Dwek R A; Rademacher T W
Characterization of the cross-reacting determinant (CRD) of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein.
European journal of biochemistry / FEBS 1988;176(3):527-34.
1988: Fleet G W; Karpas A; Dwek R A; Fellows L E; Tyms A S; Petursson S; Namgoong S K; Ramsden N G; Smith P W; Son J C
Inhibition of HIV replication by amino-sugar derivatives.
FEBS letters 1988;237(1-2):128-32.
1988: Roitt I M; Dwek R A; Parekh R B; Rademacher T W; Alavi A; Axford J; Bodman K; Bond A; Cooke A; Hay F C
Changes in carbohydrate structure of IgG in rheumatoid arthritis.
Recenti progressi in medicina 1988;79(7-8):314-7.
1988: Isenberg D A; Lydyard P M; Axford J S; Hay F C; Rook G W; Roitt I M; Sumar N; Parekh R B; Dwek R A; Rademacher T W
Galactosylation of IgG associated oligosaccharides.
Lancet 1988;2(8605):288.
1988: Ferguson M A; Homans S W; Dwek R A; Rademacher T W
The glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein.
Biochemical Society transactions 1988;16(3):265-8.
1988: Parekh R; Roitt I; Isenberg D; Dwek R; Rademacher T
Age-related galactosylation of the N-linked oligosaccharides of human serum IgG.
The Journal of experimental medicine 1988;167(5):1731-6.
1988: Homans S W; Ferguson M A; Dwek R A; Rademacher T W; Anand R; Williams A F
Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein.
Nature 1988;333(6170):269-72.
1988: Parekh R B; Roitt I M; Isenberg D A; Dwek R A; Ansell B M; Rademacher T W
Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and juvenile onset rheumatoid arthritis and relation to disease activity.
Lancet 1988;1(8592):966-9.
1988: Ferguson M A; Homans S W; Dwek R A; Rademacher T W
Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane.
Science (New York, N.Y.) 1988;239(4841 Pt 1):753-9.
1988: Rademacher T W; Parekh R B; Dwek R A
Glycobiology.
Annual review of biochemistry 1988;57():785-838.
1987: Homans S W; Pastore A; Dwek R A; Rademacher T W
Structure and dynamics in oligomannose-type oligosaccharides.
Biochemistry 1987;26(21):6649-55.
1987: Homans S W; Dwek R A; Rademacher T W
Tertiary structure in N-linked oligosaccharides.
Biochemistry 1987;26(20):6553-60.
1987: Homans S W; Dwek R A; Rademacher T W
Solution conformations of N-linked oligosaccharides.
Biochemistry 1987;26(21):6571-8.
1987: Ashford D; Dwek R A; Welply J K; Amatayakul S; Homans S W; Lis H; Taylor G N; Sharon N; Rademacher T W
The beta 1----2-D-xylose and alpha 1----3-L-fucose substituted N-linked oligosaccharides from Erythrina cristagalli lectin. Isolation, characterisation and comparison with other legume lectins.
European journal of biochemistry / FEBS 1987;166(2):311-20.
1987: Zamze S E; Ferguson M A; Moxon E R; Dwek R A; Rademacher T W
Identification of phosphorylated 3-deoxy-manno-octulosonic acid as a component of Haemophilus influenzae lipopolysaccharide.
The Biochemical journal 1987;245(2):583-7.

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