Linda Dwoskin

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Struthers Amanda M; Wilkinson Jamie L; Dwoskin Linda P; Crooks Peter A; Bevins Rick A
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine.
Smith Andrew M; Dhawan Gurpreet K; Zhang Zhenfa; Siripurapu Kiran B; Crooks Peter A; Dwoskin Linda P
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Dwoskin Linda P; Smith Andrew M; Wooters Thomas E; Zhang Zhenfa; Crooks Peter A; Bardo Michael T
Nicotinic receptor-based therapeutics and candidates for smoking cessation.

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All Publications

2009: Struthers Amanda M; Wilkinson Jamie L; Dwoskin Linda P; Crooks Peter A; Bevins Rick A
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine.
Pharmacology, biochemistry, and behavior 2009;94(2):319-28.
2009: Smith Andrew M; Dhawan Gurpreet K; Zhang Zhenfa; Siripurapu Kiran B; Crooks Peter A; Dwoskin Linda P
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Biochemical pharmacology 2009;78(7):889-97.
2009: Dwoskin Linda P; Smith Andrew M; Wooters Thomas E; Zhang Zhenfa; Crooks Peter A; Bardo Michael T
Nicotinic receptor-based therapeutics and candidates for smoking cessation.
Biochemical pharmacology 2009;78(7):732-43.
2009: López-Hernández Gretchen Y; Thinschmidt Jeffrey S; Zheng Guangrong; Zhang Zhenfa; Crooks Peter A; Dwoskin Linda P; Papke Roger L
Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists.
Molecular pharmacology 2009;76(3):652-66.
2009: Zheng Fang; McConnell Matthew J; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum.
Bioorganic & medicinal chemistry 2009;17(13):4477-85.
2009: Zhu Jun; Apparsundaram Subbu; Dwoskin Linda P
Nicotinic receptor activation increases [3H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex.
The Journal of pharmacology and experimental therapeutics 2009;328(3):931-9.
2009: Zheng Fang; Zheng Guangrong; Deaciuc A Gabriela; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):157-68.
2009: Dwoskin Linda P; Pivavarchyk Marharyta; Joyce B Matthew; Neugebauer Nichole M; Zheng Guangrong; Zhang Zhenfa; Bardo Michael T; Crooks Peter A
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2009;55():31-63.
2008: Rahman Shafiqur; Neugebauer Nichole M; Zhang Zhenfa; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens.
European journal of pharmacology 2008;601(1-3):103-5.
2008: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Crooks Peter A
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry letters 2008;18(24):6509-12.
2008: Zhang Zhenfa; Zheng Guangrong; Pivavarchyk Marharyta; Deaciuc A Gabriela; Dwoskin Linda P; Crooks Peter A
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2008;18(21):5753-7.
2008: Zhang Zhenfa; Lockman Paul R; Mittapalli Rajendar K; Allen David D; Dwoskin Linda P; Crooks Peter A
bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2008;18(20):5622-5.
2008: Albayati Zaineb A Fadhel; Dwoskin Linda P; Crooks Peter A
Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2024-9.
2008: Dwoskin Linda P; Wooters Thomas E; Sumithran Sangeetha P; Siripurapu Kiran B; Joyce B Matthew; Lockman Paul R; Manda Vamshi K; Ayers Joshua T; Zhang Zhenfa; Deaciuc Agripina G; McIntosh J Michael; Crooks Peter A; Bardo Michael T
N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
The Journal of pharmacology and experimental therapeutics 2008;326(2):563-76.
2008: Papke Roger L; Dwoskin Linda P; Crooks Peter A; Zheng Guangrong; Zhang Zhenfa; McIntosh J Michael; Stokes Clare
Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.
Neuropharmacology 2008;54(8):1189-200.
2008: Lockman Paul R; Manda Vamshi K; Geldenhuys Werner J; Mittapalli Rajendar K; Thomas Fancy; Albayati Zaineb Fadhel; Crooks Peter A; Dwoskin Linda P; Allen David D
Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2008;324(1):244-50.
2007: Zheng Guangrong; Zhang Zhenfa; Pivavarchyk Marharyta; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation.
Bioorganic & medicinal chemistry letters 2007;17(24):6734-8.
2007: Norrholm Seth D; Horton David B; Dwoskin Linda P
The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes.
Neuropharmacology 2007;53(8):982-9.
2007: Zheng Guangrong; Sumithran Sangeetha P; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2007;17(24):6701-6.
2007: Dwoskin Linda P; Joyce B Matthew; Zheng Guangrong; Neugebauer Nichole M; Manda Vamshi K; Lockman Paul; Papke Roger L; Bardo Michael T; Crooks Peter A
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
Biochemical pharmacology 2007;74(8):1271-82.
2007: Neugebauer Nichole M; Harrod Steven B; Stairs Dustin J; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
Lobelane decreases methamphetamine self-administration in rats.
European journal of pharmacology 2007;571(1):33-8.
2007: Zhu Jun; Bardo Michael T; Bruntz Ronald C; Stairs Dustin J; Dwoskin Linda P
Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression.
The European journal of neuroscience 2007;26(3):717-28.
2007: Zheng Fang; Zheng Guangrong; Deaciuc A Gabriela; Zhan Chang-Guo; Dwoskin Linda P; Crooks Peter A
Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2007;15(8):2975-92.
2007: Papke Roger L; Dwoskin Linda P; Crooks Peter A
The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
Journal of neurochemistry 2007;101(1):160-7.
2007: Middleton Lisa S; Crooks Peter A; Wedlund Peter J; Cass Wayne A; Dwoskin Linda P
Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Synapse (New York, N.Y.) 2007;61(3):157-65.
2007: Rahman Shafiqur; Neugebauer Nichole M; Zhang Z; Crooks Peter A; Dwoskin Linda P; Bardo Michael T
The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.
Neuropharmacology 2007;52(3):755-63.
2007: Stairs D J; Neugebauer N M; Wei X; Boustany C; Hojahmat M; Cassis L A; Crooks P A; Dwoskin L P; Bardo M T
Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats.
Psychopharmacology 2007;190(2):145-55.
2007: Middleton Lisa S; Apparsundaram Subbu; King-Pospisil Kelley A; Dwoskin Linda P
Nicotine increases dopamine transporter function in rat striatum through a trafficking-independent mechanism.
European journal of pharmacology 2007;554(2-3):128-36.
2006: Chen Jianhong; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A; Bai Donglu
N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):667-80.
2006: Huang Xiaoqin; Zheng Fang; Chen Xi; Crooks Peter A; Dwoskin Linda P; Zhan Chang-Guo
Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions.
Journal of medicinal chemistry 2006;49(26):7661-74.
2006: Zheng Guangrong; Horton David B; Deaciuc Agripina G; Dwoskin Linda P; Crooks Peter A
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
Bioorganic & medicinal chemistry letters 2006;16(19):5018-21.
2006: Wooters T E; Dwoskin L P; Bardo M T
Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders.
Psychopharmacology 2006;188(1):18-27.
2006: Zheng Fang; Bayram Ersin; Sumithran Sangeetha P; Ayers Joshua T; Zhan Chang-Guo; Schmitt Jeffrey D; Dwoskin Linda P; Crooks Peter A
QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release.
Bioorganic & medicinal chemistry 2006;14(9):3017-37.
2006: Neugebauer N M; Zhang Z; Crooks P A; Dwoskin L P; Bardo M T
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Psychopharmacology 2006;184(3-4):426-34.
2006: Zheng Guangrong; Dwoskin Linda P; Crooks Peter A
Vesicular monoamine transporter 2: role as a novel target for drug development.
The AAPS journal 2006;8(4):E682-92.
2006: Dwoskin Linda P; Rauhut Anthony S; King-Pospisil Kelley A; Bardo Michael T
Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent.
CNS drug reviews 2006;12(3-4):178-207.
2005: Rauhut Anthony S; Dwoskin Linda P; Bardo Michael T
Tolerance does not develop to the decrease in nicotine self-administration produced by repeated bupropion administration.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2005;7(6):901-7.
2005: Wei Xiaochen; Sumithran Sangeetha P; Deaciuc A Gabriela; Burton Harold R; Bush Lowell P; Dwoskin Linda P; Crooks Peter A
Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
Life sciences 2005;78(5):495-505.
2005: Huang Xiaoqin; Zheng Fang; Crooks Peter A; Dwoskin Linda P; Zhan Chang-Guo
Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.
Journal of the American Chemical Society 2005;127(41):14401-14.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Crooks Peter A
Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
Bioorganic & medicinal chemistry letters 2005;15(20):4463-6.
2005: Papke Roger L; Zheng Guangrong; Horenstein Nicole A; Dwoskin Linda P; Crooks Peter A
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.
Bioorganic & medicinal chemistry letters 2005;15(17):3874-80.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Norrholm Seth D; Crooks Peter A
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
Journal of medicinal chemistry 2005;48(17):5551-60.
2005: Geldenhuys Werner J; Lockman Paul R; Nguyen Tiffany H; Van der Schyf Cornelis J; Crooks Peter A; Dwoskin Linda P; Allen David D
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry 2005;13(13):4253-61.
2005: Zhu Jun; Apparsundaram Subbu; Bardo Michael T; Dwoskin Linda P
Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex.
Journal of neurochemistry 2005;93(6):1434-43.
2005: Zheng Guangrong; Dwoskin Linda P; Deaciuc Agripina G; Zhu Jun; Jones Marlon D; Crooks Peter A
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
Bioorganic & medicinal chemistry 2005;13(12):3899-909.
2005: Wilkins Lincoln H; Miller Dennis K; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes.
The AAPS journal 2005;7(4):E922-30.
2005: Ayers Joshua T; Xu Rui; Dwoskin Linda P; Crooks Peter A
A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine.
The AAPS journal 2005;7(3):E752-8.
2005: Ayers Joshua T; Clauset Aaron; Schmitt Jeffrey D; Dwoskin Linda P; Crooks Peter A
Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques.
The AAPS journal 2005;7(3):E678-85.
2005: Sumithran Sangeetha P; Crooks Peter A; Xu Rui; Zhu Jun; Deaciuc Agripina G; Wilkins Lincoln H; Dwoskin Linda P
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
The AAPS journal 2005;7(1):E201-17.
2004: Zheng Guangrong; Dwoskin Linda P; Crooks Peter A
Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine.
The Journal of organic chemistry 2004;69(24):8514-7.
2004: Neugebauer Nichole M; Cunningham S Tiffany; Zhu Jun; Bryant Rachel I; Middleton Lisa S; Dwoskin Linda P
Effects of environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine.
Brain research. Developmental brain research 2004;153(2):213-23.
2004: Miller Dennis K; Crooks Peter A; Zheng Guangrong; Grinevich Vladimir P; Norrholm Seth D; Dwoskin Linda P
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1035-45.
2004: Harrod S B; Dwoskin L P; Bardo M T
Lobeline produces conditioned taste avoidance in rats.
Pharmacology, biochemistry, and behavior 2004;78(1):1-5.
2004: Crooks Peter A; Ayers Joshua T; Xu Rui; Sumithran Sangeetha P; Grinevich Vladimir P; Wilkins Lincoln H; Deaciuc A Gabriela; Allen David D; Dwoskin Linda P
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2004;14(8):1869-74.
2004: Dwoskin Linda P; Sumithran Sangeetha P; Zhu Jun; Deaciuc A Gabriela; Ayers Joshua T; Crooks Peter A
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.
Bioorganic & medicinal chemistry letters 2004;14(8):1863-7.
2004: Zheng Guangrong; Parkin Sean; Dwoskin Linda P; Crooks Peter A
Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol.
Acta crystallographica. Section C, Crystal structure communications 2004;60(Pt 1):o9-11.
2004: Zhu Jun; Green Thomas; Bardo Michael T; Dwoskin Linda P
Environmental enrichment enhances sensitization to GBR 12935-induced activity and decreases dopamine transporter function in the medial prefrontal cortex.
Behavioural brain research 2004;148(1-2):107-17.
2004: Middleton Lisa S; Cass Wayne A; Dwoskin Linda P
Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex.
The Journal of pharmacology and experimental therapeutics 2004;308(1):367-77.
2004: Bardo Michael T; Dwoskin Linda P
Biological connection between novelty- and drug-seeking motivational systems.
Nebraska Symposium on Motivation. Nebraska Symposium on Motivation 2004;50():127-58.
2003: Grinevich Vladimir P; Crooks Peter A; Sumithran Sangeetha P; Haubner Aaron J; Ayers Joshua T; Dwoskin Linda P
N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2003;306(3):1011-20.
2003: Rauhut Anthony S; Neugebauer Nicole; Dwoskin Linda P; Bardo Michael T
Effect of bupropion on nicotine self-administration in rats.
Psychopharmacology 2003;169(1):1-9.
2003: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar A; Dwoskin Linda P; Crooks Peter A
Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers.
Journal of clinical psychopharmacology 2003;23(2):209-11.
2003: Allen David D; Lockman Paul R; Roder Karen E; Dwoskin Linda P; Crooks Peter A
Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1268-74.
2003: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar H; Dwoskin Linda P; Crooks Peter A
A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(1):165-71.
2003: Harrod Steven B; Dwoskin Linda P; Green Thomas A; Gehrke Brenda J; Bardo Michael T
Lobeline does not serve as a reinforcer in rats.
Psychopharmacology 2003;165(4):397-404.
2003: Wilkins Lincoln H; Grinevich Vladimir P; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors.
The Journal of pharmacology and experimental therapeutics 2003;304(1):400-10.
2003: Miller Dennis K; Harrod Steven B; Green Thomas A; Wong Mei-Yee; Bardo Michael T; Dwoskin Linda P
Lobeline attenuates locomotor stimulation induced by repeated nicotine administration in rats.
Pharmacology, biochemistry, and behavior 2003;74(2):279-86.
2003: Chen Jianhong; Norrholm Seth; Dwoskin Linda P; Crooks Peter A; Bai Donglu
N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.
Bioorganic & medicinal chemistry letters 2003;13(1):97-100.
2002: Green T A; Brown R W; Phillips S B; Dwoskin L P; Bardo M T
Locomotor stimulant effects of nornicotine: role of dopamine.
Pharmacology, biochemistry, and behavior 2002;74(1):87-94.
2002: Rauhut Anthony S; Mullins Stephanie N; Dwoskin Linda P; Bardo Michael T
Reboxetine: attenuation of intravenous nicotine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2002;303(2):664-72.
2002: Ayers Joshua T; Dwoskin Linda P; Deaciuc A Gabriela; Grinevich Vladimir P; Zhu Jun; Crooks Peter A
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.
Bioorganic & medicinal chemistry letters 2002;12(21):3067-71.
2002: de Leon Jose; Diaz Francisco J; Rogers Thea; Browne Debra; Dinsmore Lori; Ghosheh Omar H; Dwoskin Linda P; Crooks Peter A
Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke.
Journal of clinical psychopharmacology 2002;22(5):496-501.
2002: Miller Dennis K; Sumithran Sangeetha P; Dwoskin Linda P
Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1113-22.
2002: Miller Dennis K; Wong Erik H F; Chesnut M Dathan; Dwoskin Linda P
Reboxetine: functional inhibition of monoamine transporters and nicotinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics 2002;302(2):687-95.
2002: Wilkins Lincoln H; Haubner Aaron; Ayers Joshua T; Crooks Peter A; Dwoskin Linda P
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1088-96.
2002: Maragos William F; Zhu Jun; Chesnut M Dathan; Dwoskin Linda P
Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes.
Biochemical pharmacology 2002;63(8):1499-505.
2002: Dwoskin Linda P; Crooks Peter A
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.
Biochemical pharmacology 2002;63(2):89-98.
2001: Green T A; Crooks P A; Bardo M T; Dwoskin L P
Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices.
Biochemical pharmacology 2001;62(12):1597-603.
2001: Dwoskin L P; Teng L H; Crooks P A
Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum.
European journal of pharmacology 2001;428(1):69-79.
2001: Miller D K; Wilkins L H; Bardo M T; Crooks P A; Dwoskin L P
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism.
Psychopharmacology 2001;156(4):469-76.
2001: Dwoskin L P; Crooks P A
Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.
The Journal of pharmacology and experimental therapeutics 2001;298(2):395-402.
2001: Harrod S B; Dwoskin L P; Crooks P A; Klebaur J E; Bardo M T
Lobeline attenuates d-methamphetamine self-administration in rats.
The Journal of pharmacology and experimental therapeutics 2001;298(1):172-9.
2001: Xu R; Dwoskin L P; Grinevich V P; Deaciuc G; Crooks P A
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.
Bioorganic & medicinal chemistry letters 2001;11(9):1245-8.
2001: Ghosheh O A; Dwoskin L P; Miller D K; Crooks P A
Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(5):645-51.
2001: Miller D K; Crooks P A; Teng L; Witkin J M; Munzar P; Goldberg S R; Acri J B; Dwoskin L P
Lobeline inhibits the neurochemical and behavioral effects of amphetamine.
The Journal of pharmacology and experimental therapeutics 2001;296(3):1023-34.
2001: Butt C M; Pauly J R; Wilkins L H; Dwoskin L P; Debski E A
Pharmacology, distribution and development of muscarinic acetylcholine receptor subtypes in the optic tectum of Rana pipiens.
Neuroscience 2001;104(1):161-79.
2000: Green T A; Phillips S B; Crooks P A; Dwoskin L P; Bardo M T
Nornicotine pretreatment decreases intravenous nicotine self-administration in rats.
Psychopharmacology 2000;152(3):289-94.
2000: Miller D K; Crooks P A; Dwoskin L P
Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes.
Neuropharmacology 2000;39(13):2654-62.
2000: Ghosheh O A; Browne D; Rogers T; de Leon J; Dwoskin L P; Crooks P A
A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers.
Journal of pharmaceutical and biomedical analysis 2000;23(2-3):543-9.
1999: Ghosheh O; Dwoskin L P; Li W K; Crooks P A
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(12):1448-55.
1999: Bardo M T; Green T A; Crooks P A; Dwoskin L P
Nornicotine is self-administered intravenously by rats.
Psychopharmacology 1999;146(3):290-6.
1999: Dwoskin L P; Crooks P A; Teng L; Green T A; Bardo M T
Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine.
Psychopharmacology 1999;145(4):442-51.
1999: Dwoskin L P; Wilkins L H; Pauly J R; Crooks P A
Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs.
Annals of the New York Academy of Sciences 1999;868():617-9.
1999: Dwoskin L P; Teng L; Buxton S T; Crooks P A
(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner.
The Journal of pharmacology and experimental therapeutics 1999;288(3):905-11.
1999: King V L; Dwoskin L P; Cassis L A
Cold exposure regulates the norepinephrine uptake transporter in rat brown adipose tissue.
The American journal of physiology 1999;276(1 Pt 2):R143-51.
1999: Maragos W F; Jakel R J; Chesnut M D; Geddes J W; Dwoskin L P
Does dopamine contribute to striatal damage caused by impaired mitochondrial function?
Annals of the New York Academy of Sciences 1999;893():345-9.
1998: Cassis L; Laughter A; Fettinger M; Akers S; Speth R; Burke G; King V; Dwoskin L
Cold exposure regulates the renin-angiotensin system.
The Journal of pharmacology and experimental therapeutics 1998;286(2):718-26.
1998: Teng L; Crooks P A; Dwoskin L P
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.
Journal of neurochemistry 1998;71(1):258-65.
1997: Bardo M T; Bevins R A; Klebaur J E; Crooks P A; Dwoskin L P
(-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats.
Pharmacology, biochemistry, and behavior 1997;58(4):1083-7.
1997: Teng L; Crooks P A; Buxton S T; Dwoskin L P
Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine.
The Journal of pharmacology and experimental therapeutics 1997;283(2):778-87.
1997: Crooks P A; Dwoskin L P
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking.
Biochemical pharmacology 1997;54(7):743-53.
1997: Teng L; Crooks P A; Sonsalla P K; Dwoskin L P
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1432-44.
1997: Crooks P A; Li M; Dwoskin L P
Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(1):47-54.
1995: Crooks P A; Li M; Dwoskin L P
Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(10):1175-7.
1995: Bardo M T; Bowling S L; Rowlett J K; Manderscheid P; Buxton S T; Dwoskin L P
Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine.
Pharmacology, biochemistry, and behavior 1995;51(2-3):397-405.
1995: Dwoskin L P; Teng L; Buxton S T; Ravard A; Deo N; Crooks P A
Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices.
European journal of pharmacology 1995;276(1-2):195-9.
1994: Cassis L A; Dwoskin L P
Acute and chronic losartan administration: effect on angiotensin II content and modulation of [3H]norepinephrine release from rat interscapular brown adipose tissue.
Journal of neural transmission. General section 1994;98(2):159-64.
1993: Jewell A; Wedlund P; Dwoskin L
Strain differences in rat brain and liver sigma binding: lack of cytochrome P450-2D1 involvement.
European journal of pharmacology 1993;243(3):249-54.
1993: Dwoskin L P; Buxton S T; Jewell A L; Crooks P A
S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices.
Journal of neurochemistry 1993;60(6):2167-74.
1993: Soltis E E; Jewell A L; Dwoskin L P; Cassis L A
Acute and chronic effects of losartan (DuP 753) on blood pressure and vascular reactivity in normotensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1993;15(1):171-84.
1992: Dwoskin L P; Jewell A L; Buxton S T; Carney J M
Phencyclidine-induced desensitization of striatal dopamine release.
Neuropharmacology 1992;31(10):1033-9.
1992: Dwoskin L P; Jewell A L; Cassis L A
DuP 753, a nonpeptide angiotensin II-1 receptor antagonist, alters dopaminergic function in rat striatum.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(2):153-9.
1992: Dwoskin L P; Leibee L L; Jewell A L; Fang Z X; Crooks P A
Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites.
Life sciences 1992;50(25):PL233-7.
1991: Cassis L A; Dwoskin L P
Presynaptic modulation of neurotransmitter release by endogenous angiotensin II in brown adipose tissue.
Journal of neural transmission. Supplementum 1991;34():129-37.

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