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Lori Dwyer-Nield

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Alpna Tyagi; Chapla Agarwal; Lori D Dwyer-Nield; Alvin M Malkinson; Rana P Singh; Rajesh Agarwal
Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Kumaraguruparan Ramasamy; Lori D Dwyer-Nield; Natalie J Serkova; Kendra M Hasebroock; Alpna Tyagi; Komal Raina; Rana P Singh; Alvin M Malkinson; Rajesh Agarwal
Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.
Pamela L Rice; Bradley S Barrett; Jason M Fritz; Mary C Srebernak; Lori R Kisley; Alvin M Malkinson; Lori D Dwyer-Nield
Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells.

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2012: Alpna Tyagi; Chapla Agarwal; Lori D Dwyer-Nield; Alvin M Malkinson; Rana P Singh; Rajesh Agarwal
Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Molecular carcinogenesis 2012;51(10):832-42.
2011: Kumaraguruparan Ramasamy; Lori D Dwyer-Nield; Natalie J Serkova; Kendra M Hasebroock; Alpna Tyagi; Komal Raina; Rana P Singh; Alvin M Malkinson; Rajesh Agarwal
Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(4):753-61.
2010: Pamela L Rice; Bradley S Barrett; Jason M Fritz; Mary C Srebernak; Lori R Kisley; Alvin M Malkinson; Lori D Dwyer-Nield
Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells.
Experimental lung research 2010;36(9):558-71.
2010: Elizabeth F Redente; David M Higgins; Lori D Dwyer-Nield; Ian M Orme; Mercedes Gonzalez-Juarrero; Alvin M Malkinson
Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.
Journal of leukocyte biology 2010;88(1):159-68.
2010: Elizabeth F Redente; Lori D Dwyer-Nield; Daniel T Merrick; Komal Raina; Rajesh Agarwal; William Pao; Pamela L Rice; Kenneth R Shroyer; Alvin M Malkinson
Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.
The American journal of pathology 2010;176(6):2972-85.
2010: Jason M Fritz; Lori D Dwyer-Nield; Bridgette M Russell; Alvin M Malkinson
The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(2):254-7.
2010: Lori D Dwyer-Nield; Jay McQuillan; Annie Hill-Baskin; Richard Radcliffe; Ming You; Joseph H Nadeau; Alvin M Malkinson
Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains.
International journal of cancer. Journal international du cancer 2010;126(1):125-32.
2009: Elizabeth F Redente; Lori D Dwyer-Nield; Bradley S Barrett; David W H Riches; Alvin M Malkinson
Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice.
Anticancer research 2009;29(12):5095-101.
2009: Alpna Tyagi; Rana Singh; Kumaraguruparan Ramasamy; Komal Raina; Elizabeth F Redente; Lori D Dwyer-Nield; Richard A Radcliffe; Alvin M Malkinson; Rajesh Agarwal
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):74-83.
2008: Laura K Zerbe; Lori D Dwyer-Nield; Jason M Fritz; Elizabeth F Redente; Robert J Shroyer; Elizabeth Conklin; Shawn Kane; Chris Tucker; S Gail Eckhardt; Daniel L Gustafson; Kenneth K Iwata; Alvin M Malkinson
Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice.
Cancer chemotherapy and pharmacology 2008;62(4):605-20.
2008: Robert Stearman; Lori D Dwyer-Nield; Michael C Grady; Alvin M Malkinson; Mark W Geraci
A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.
Cancer research 2008;68(1):34-43.
2007: Katherine A Peebles; Lori D Dwyer-Nield; Alvin M Malkinson
Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia.
Molecular carcinogenesis 2007;46(11):887-900.
2006: E Paul O'Donnell; Laura K Zerbe; Lori D Dwyer-Nield; Lori R Kisley; Alvin M Malkinson
Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis.
Cancer letters 2006;241(2):197-202.
2006: Robert L Keith; Mark W Geraci; S Patrick Nana-Sinkam; Richard M Breyer; Tyler M Hudish; Amy M Meyer; Alvin M Malkinson; Lori D Dwyer-Nield
Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.
Anticancer research 2006;26(4B):2857-61.
2006: Rana Singh; Gagan Deep; Manesh Chittezhath; Manjinder Kaur; Lori D Dwyer-Nield; Alvin M Malkinson; Rajesh Agarwal
Effect of silibinin on the growth and progression of primary lung tumors in mice.
Journal of the National Cancer Institute 2006;98(12):846-55.
2006: Amy M Meyer; Lori D Dwyer-Nield; Greg Hurteau; Robert L Keith; Yanli Ouyang; Brian M Freed; Lori R Kisley; Mark W Geraci; Joseph V Bonventre; Raphael A Nemenoff; Alvin M Malkinson
Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.
American journal of physiology. Lung cellular and molecular physiology 2006;290(6):L1260-6.
2005: Robert Stearman; Lori D Dwyer-Nield; Laura K Zerbe; Stacy A Blaine; Zeng Chan; Paul A Bunn; Gary L Johnson; Fred R Hirsch; Daniel T Merrick; Wilbur A Franklin; Anna E Baron; Robert L Keith; Raphael A Nemenoff; Alvin M Malkinson; Mark W Geraci
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
The American journal of pathology 2005;167(6):1763-75.
2005: Lori D Dwyer-Nield; Mary C Srebernak; Bradley S Barrett; Jinhee Ahn; Pippa Cosper; Amy M Meyer; Lori R Kisley; Alison K Bauer; David C Thompson; Alvin M Malkinson
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines.
Carcinogenesis 2005;26(7):1196-206.
2004: Laura K Zerbe; Irene Pino; Ruben Pio; Pippa F Cosper; Lori D Dwyer-Nield; Amy M Meyer; J. David Port; Luis M Montuenga; Alvin M Malkinson
Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.
Molecular carcinogenesis 2004;41(4):187-96.
2004: Yingnian Lu; Donald Bellgrau; Lori D Dwyer-Nield; Alvin M Malkinson; Richard C Duke; Timothy C Rodell; Alex Franzusoff
Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy.
Cancer research 2004;64(15):5084-8.
2004: Amy M Meyer; Lori D Dwyer-Nield; Greg Hurteau; Robert L Keith; Eileen O'Leary; Ming You; Joseph V Bonventre; Raphael A Nemenoff; Alvin M Malkinson
Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.
Carcinogenesis 2004;25(8):1517-24.
2004: Feijie Zhang; William Pao; Sarah M Umphress; Sonia B Jakowlew; Amy M Meyer; Lori D Dwyer-Nield; Katsuyuki Takeda; Erwin W Gelfand; J Fisher; Alvin M Malkinson; Robert J Mason
Serum levels of surfactant protein D are increased in mice with lung tumors.
Chest 2004;125(5 Suppl):109S.
2003: Feijie Zhang; William Pao; Sarah M Umphress; Sonia B Jakowlew; Amy M Meyer; Lori D Dwyer-Nield; Larry D Nielsen; Katsuyuki Takeda; Erwin W Gelfand; James H Fisher; Lening Zhang; Alvin M Malkinson; Robert J Mason
Serum levels of surfactant protein D are increased in mice with lung tumors.
Cancer research 2003;63(18):5889-94.
2003: York E Miller; Lori D Dwyer-Nield; Robert L Keith; Mysan Le; Wilbur A Franklin; Alvin M Malkinson
Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections.
Cancer letters 2003;198(2):139-44.
2003: Yude Sun; Lori D Dwyer-Nield; Alvin M Malkinson; Yan Ling Zhang; John A Thompson
Responses of tumorigenic and non-tumorigenic mouse lung epithelial cell lines to electrophilic metabolites of the tumor promoter butylated hydroxytoluene.
Chemico-biological interactions 2003;145(1):41-51.
2003: Lori D Dwyer-Nield; David Dinsdale; J John Cohen; Margaret K T Squier; Alvin M Malkinson
Morphological assessment of apoptosis in human lung cells.
Methods in molecular medicine 2003;74():283-97.
2002: Lori R Kisley; Bradley S Barrett; Alison K Bauer; Lori D Dwyer-Nield; Ben Barthel; Amy M Meyer; David C Thompson; Alvin M Malkinson
Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.
Cancer research 2002;62(23):6850-6.
2002: Lori R Kisley; Bradley S Barrett; Lori D Dwyer-Nield; Alison K Bauer; David C Thompson; Alvin M Malkinson
Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.
Carcinogenesis 2002;23(10):1653-60.
2002: Rene Kupfer; Lori D Dwyer-Nield; Alvin M Malkinson; John A Thompson
Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity.
Chemical research in toxicology 2002;15(8):1106-12.
2002: Alvin M Malkinson; Richard Radcliffe; Alison K Bauer; Lori D Dwyer-Nield; Steven Kleeberger
Quantitative trait loci that regulate susceptibility to both butylated hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CXB recombinant inbred mice.
Chest 2002;121(3 Suppl):82S.
2001: Alison K Bauer; Lori D Dwyer-Nield; J A Hankin; Robert C Murphy; Alvin M Malkinson
The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice.
Toxicology 2001;169(1):1-15.
2001: C L Mamay; IE Schauer; Pamela L Rice; Amy L McDoniels-Silvers; Lori D Dwyer-Nield; M You; Robert A Sclafani; Alvin M Malkinson
Cyclin D1 as a proliferative marker regulating retinoblastoma phosphorylation in mouse lung epithelial cells.
Cancer letters 2001;168(2):165-72.
2001: Stephanie E Porter; Lori D Dwyer-Nield; Alvin M Malkinson
Regulation of lung epithelial cell morphology by cAMP-dependent protein kinase type I isozyme.
American journal of physiology. Lung cellular and molecular physiology 2001;280(6):L1282-9.
2001: Randall J Ruch; S Porter; Lucas D Koffler; Lori D Dwyer-Nield; Alvin M Malkinson
Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation.
Experimental lung research 2001;27(3):231-43.
2001: Alison K Bauer; Lori D Dwyer-Nield; K Keil; KM Koski; Alvin M Malkinson
Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion.
Experimental lung research 2001;27(3):197-216.
2001: John A Thompson; T J Carlson; Y Sun; Lori D Dwyer-Nield; Alvin M Malkinson
Studies using structural analogs and inbred strain differences to support a role for quinone methide metabolites of butylated hydroxytoluene (BHT) in mouse lung tumor promotion.
Toxicology 2001;160(1-3):197-205.
2000: Lucas D Koffler; S Roshong; I Kyu Park; K Cesen-Cummings; D C Thompson; Lori D Dwyer-Nield; P Rice; C Mamay; Alvin M Malkinson; Randall J Ruch
Growth inhibition in G(1) and altered expression of cyclin D1 and p27(kip-1 )after forced connexin expression in lung and liver carcinoma cells.
Journal of cellular biochemistry 2000;79(3):347-54.
2000: Lori D Dwyer-Nield; B Paigen; Stephanie E Porter; Alvin M Malkinson
Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha content.
American journal of physiology. Lung cellular and molecular physiology 2000;279(2):L326-32.
2000: Burns C Blaxall; Lori D Dwyer-Nield; Alison K Bauer; Teresa J Bohlmeyer; Alvin M Malkinson; J. David Port
Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue.
Molecular carcinogenesis 2000;28(2):76-83.
2000: Alison K Bauer; Lori D Dwyer-Nield; Alvin M Malkinson
High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors.
Carcinogenesis 2000;21(4):543-50.
1998: Lori D Dwyer-Nield; John A Thompson; G Peljak; Margaret K T Squier; T D Barker; A Parkinson; J John Cohen; David Dinsdale; Alvin M Malkinson
Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion.
Toxicology 1998;130(2-3):115-27.
1998: Alvin M Malkinson; KM Koski; Lori D Dwyer-Nield; Pamela L Rice; Nathalie Rioux; André Castonguay; Dennis J Ahnen; H Thompson; Rifat Pamukcu; Gary Piazza
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).
Carcinogenesis 1998;19(8):1353-6.
1998: David C Thompson; Stephanie E Porter; Alison K Bauer; Kumuda C Das; B Ou; Lori D Dwyer-Nield; Carl W White; Alvin M Malkinson
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines.
The American journal of physiology 1998;274(6 Pt 1):L922-32.
1997: Alvin M Malkinson; Lori D Dwyer-Nield; Pamela L Rice; David Dinsdale
Mouse lung epithelial cell lines--tools for the study of differentiation and the neoplastic phenotype.
Toxicology 1997;123(1-2):53-100.
1996: Lori D Dwyer-Nield; A C Miller; B W Neighbors; D Dinsdale; Alvin M Malkinson
Cytoskeletal architecture in mouse lung epithelial cells is regulated by protein-kinase C-alpha and calpain II.
The American journal of physiology 1996;270(4 Pt 1):L526-34.
1995: A C Miller; Lori D Dwyer-Nield; Alvin M Malkinson
Very early changes in pulmonary protein kinase C-alpha and calpain II contents following injection of butylated hydroxytoluene (BHT) into mice.
Toxicology 1995;97(1-3):141-9.