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Nancy Dwyer

Research Profile

Anatomy

Disorders

Niemann-Pick Diseases

Chemicals & Drugs

Procedures

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Physiology

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Anthony T Craig; Oksana Gavrilova; Nancy K Dwyer; William Jou; Stephanie Pack; Eric Liu; Klaus Pechhold; Michael Schmidt; Victor J McAlister; John A Chiorini; E Joan Blanchette-Mackie; David M Harlan; Roland A Owens
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Tatsuro Kishida; Igor Kostetskii; Zhibing Zhang; Federico Martinez; Pei Liu; Steven U Walkley; Nancy K Dwyer; E Joan Blanchette-Mackie; Glenn L Radice; Jerome F Strauss
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
Edward B Neufeld; John Anthony Stonik; Stephen J Demosky; Catherine L Knapper; Christian A Combs; Adele Cooney; Marcy Comly; Nancy K Dwyer; Joan Blanchette-Mackie; Alan T Remaley; Silvia Santamarina-Fojo; H Bryan Brewer
The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.

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All Publications

2009: Anthony T Craig; Oksana Gavrilova; Nancy K Dwyer; William Jou; Stephanie Pack; Eric Liu; Klaus Pechhold; Michael Schmidt; Victor J McAlister; John A Chiorini; E Joan Blanchette-Mackie; David M Harlan; Roland A Owens
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Virology journal 2009;6():61.
2004: Tatsuro Kishida; Igor Kostetskii; Zhibing Zhang; Federico Martinez; Pei Liu; Steven U Walkley; Nancy K Dwyer; E Joan Blanchette-Mackie; Glenn L Radice; Jerome F Strauss
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.
The Journal of biological chemistry 2004;279(18):19276-85.
2004: Edward B Neufeld; John Anthony Stonik; Stephen J Demosky; Catherine L Knapper; Christian A Combs; Adele Cooney; Marcy Comly; Nancy K Dwyer; Joan Blanchette-Mackie; Alan T Remaley; Silvia Santamarina-Fojo; H Bryan Brewer
The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.
The Journal of biological chemistry 2004;279(15):15571-8.
2003: Mei Zhang; M Sun; Nancy K Dwyer; Marcy Comly; Shutish C Patel; R Sundaram; John Hanover; E Joan Blanchette-Mackie
Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2003;92(443):63-73; discussion 45.
2002: Mei Zhang; Pei Liu; Nancy K Dwyer; Lane K Christenson; Toshio Fujimoto; Federico Martinez; Marcy Comly; John Hanover; E Joan Blanchette-Mackie; Jerome F Strauss
MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.
The Journal of biological chemistry 2002;277(36):33300-10.
2001: Edward B Neufeld; Alan T Remaley; Stephen J Demosky; John Anthony Stonik; Adele Cooney; Marcy Comly; Nancy K Dwyer; Mei Zhang; Joan Blanchette-Mackie; Silvia Santamarina-Fojo; H Bryan Brewer
Cellular localization and trafficking of the human ABCA1 transporter.
The Journal of biological chemistry 2001;276(29):27584-90.
2001: Mei Zhang; Nancy K Dwyer; Dona C Love; Adele Cooney; Marcy Comly; E Neufeld; Peter G Pentchev; E Joan Blanchette-Mackie; John Hanover
Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4466-71.
2001: Mei Zhang; Nancy K Dwyer; Edward B Neufeld; Dona C Love; Adele Cooney; Marcy Comly; S Patel; Hidemichi Watari; Jerome F Strauss; Peter G Pentchev; John Hanover; E Joan Blanchette-Mackie
Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.
The Journal of biological chemistry 2001;276(5):3417-25.
2000: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Michiko Watari; Christopher G Burd; Sapana Patel; Peter G Pentchev; Jerome F Strauss
Determinants of NPC1 expression and action: key promoter regions, posttranscriptional control, and the importance of a "cysteine-rich" loop.
Experimental cell research 2000;259(1):247-56.
2000: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Gwo-Shing Sun; J M Glick; Sapana Patel; Edward B Neufeld; Peter G Pentchev; Jerome F Strauss
NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.
Experimental cell research 2000;255(1):56-66.
1999: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; Michiko Watari; Edward B Neufeld; Sapana Patel; Peter G Pentchev; Jerome F Strauss
Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein.
The Journal of biological chemistry 1999;274(31):21861-6.
1999: S Doren; N Landsberger; Nancy K Dwyer; Lyn Gold; Joan Blanchette-Mackie; Jurrien Dean
Incorporation of mouse zona pellucida proteins into the envelope of Xenopus laevis oocytes.
Development genes and evolution 1999;209(6):330-9.
1999: Edward B Neufeld; Meryl E Wastney; S Patel; Subra Suresh; Adele Cooney; Nancy K Dwyer; C F Roff; K Ohno; JA Morris; ED Carstea; John P Incardona; Jerome F Strauss; marie T vanier; M C Patterson; Roscoe O Brady; Peter G Pentchev; E Joan Blanchette-Mackie
The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.
The Journal of biological chemistry 1999;274(14):9627-35.
1999: Hidemichi Watari; E Joan Blanchette-Mackie; Nancy K Dwyer; J M Glick; Sapana Patel; Edward B Neufeld; Roscoe O Brady; Peter G Pentchev; Jerome F Strauss
Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):805-10.
1998: S Hasegawa; Griffin P Rodgers; Nancy K Dwyer; Constance Tom Noguchi; E Joan Blanchette-Mackie; N Uyesaka; Alan N Schechter; Eitan Fibach
Sickling of nucleated erythroid precursors from patients with sickle cell anemia.
Experimental hematology 1998;26(4):314-9.
1998: Jeffery L Miller; M Giattina; E J Mackie; Nancy K Dwyer
Variegated transfer of recombinant glycosylphosphatidylinositol-anchored CD4 among cultured cells: correlation of flow cytometric and microscopic observations.
The Journal of laboratory and clinical medicine 1998;131(3):215-21.
1998: Raphael Schiffmann; Nancy K Dwyer; Irina A Lubensky; Maria Tsokos; V E Sutliff; J S Latimer; Karen P Frei; Roscoe O Brady; Norman W Barton; E Joan Blanchette-Mackie; Ehud Goldin
Constitutive achlorhydria in mucolipidosis type IV.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1207-12.
1997: Daniela Malide; Nancy K Dwyer; E Joan Blanchette-Mackie; Samuel W Cushman
Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(8):1083-96.
1996: Tracy L Rankin; M Familari; Eric Lee; A Ginsberg; Nancy K Dwyer; J Blanchette-Mackie; John Drago; Heiner Westphal; Jurrien Dean
Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile.
Development (Cambridge, England) 1996;122(9):2903-10.
1996: Edward B Neufeld; Adele Cooney; J Pitha; E A Dawidowicz; Nancy K Dwyer; Peter G Pentchev; E Joan Blanchette-Mackie
Intracellular trafficking of cholesterol monitored with a cyclodextrin.
The Journal of biological chemistry 1996;271(35):21604-13.
1996: Constantine Londos; J Gruia-Gray; Dawn L Brasaemle; cristina Rondinone; T Takeda; Nancy K Dwyer; T Barber; Alan R Kimmel; E Joan Blanchette-Mackie
Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20 Suppl 3():S97-101.
1995: E Joan Blanchette-Mackie; Nancy K Dwyer; T Barber; R A Coxey; T Takeda; cristina Rondinone; J L Theodorakis; A S Greenberg; Constantine Londos
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.
Journal of lipid research 1995;36(6):1211-26.
1995: Ehud Goldin; E Joan Blanchette-Mackie; Nancy K Dwyer; Peter G Pentchev; Roscoe O Brady
Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent.
Pediatric research 1995;37(6):687-92.
1994: Daniele Szapary; T Barber; Nancy K Dwyer; E Joan Blanchette-Mackie; S Stoney Simons
Microtubules are not required for glucocorticoid receptor mediated gene induction.
The Journal of steroid biochemistry and molecular biology 1994;51(3-4):143-8.
1990: C E Argoff; Christine R Kaneski; E Joan Blanchette-Mackie; M Comly; Nancy K Dwyer; A Brown; Roscoe O Brady; Peter G Pentchev
Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.
Biochemical and biophysical research communications 1990;171(1):38-45.
1989: E Joan Blanchette-Mackie; Nancy K Dwyer; marie T vanier; J Sokol; H F Merrick; M E Comly; C E Argoff; Peter G Pentchev
Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts.
Biochimica et biophysica acta 1989;1006(2):219-26.
1989: E Joan Blanchette-Mackie; Hiroshi Masuno; Nancy K Dwyer; Thomas Olivecrona; R O Scow
Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study.
The American journal of physiology 1989;256(6 Pt 1):E818-28.
1989: E Joan Blanchette-Mackie; Nancy K Dwyer; L A Amende
Cytochemical studies of lipid metabolism: immunogold probes for lipoprotein lipase and cholesterol.
The American journal of anatomy 1989;185(2-3):255-63.
1988: E Joan Blanchette-Mackie; Nancy K Dwyer; L M Amende; Howard S Kruth; J D Butler; J Sokol; M E Comly; marie T vanier; Thomas August; Roscoe O Brady
Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8022-6.
1988: J Sokol; J Blanchette-Mackie; Howard S Kruth; Nancy K Dwyer; L M Amende; J D Butler; E Robinson; Sapana Patel; Roscoe O Brady; M E Comly
Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.
The Journal of biological chemistry 1988;263(7):3411-7.