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Jason Dyck

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TOP 3
Bernard P C Kok; Jason R B Dyck; Thurl E Harris; David N Brindley
Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
Jacob Jeppesen; Niels Jessen; Andreas Børsting Jordy; Jason R B Dyck; Andreas M Fritzen; Roger W Hunter; Stine J Maarbjerg; Christian Pehmøller; Clara Prats; Klaus Qvortrup; Erik A Richter; Kei Sakamoto; Peter Schjerling; Annette Karen Serup; Lykke Sylow; David M Thomson; Kasper Thorsen; Jørgen F P Wojtaszewski; Bente Kiens
LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK.
THOMAS CHACKO PULINILKUNNIL; Terri J Waller; Martin E Young; Rudolf Zechner; Guenter Haemmerle; Erin E Kershaw; Petra C Kienesberger; Gregory Korbutt; Jeevan Nagendran; Jason R B Dyck
Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy.

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All Publications

2013: Bernard P C Kok; Jason R B Dyck; Thurl E Harris; David N Brindley
Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.
Journal of lipid research 2013;54(6):1662-77.
2013: Jacob Jeppesen; Niels Jessen; Andreas Børsting Jordy; Jason R B Dyck; Andreas M Fritzen; Roger W Hunter; Stine J Maarbjerg; Christian Pehmøller; Clara Prats; Klaus Qvortrup; Erik A Richter; Kei Sakamoto; Peter Schjerling; Annette Karen Serup; Lykke Sylow; David M Thomson; Kasper Thorsen; Jørgen F P Wojtaszewski; Bente Kiens
LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK.
Diabetes 2013;62(5):1490-9.
2013: THOMAS CHACKO PULINILKUNNIL; Terri J Waller; Martin E Young; Rudolf Zechner; Guenter Haemmerle; Erin E Kershaw; Petra C Kienesberger; Gregory Korbutt; Jeevan Nagendran; Jason R B Dyck
Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy.
Diabetes 2013;62(5):1464-77.
2013: Jeevan Nagendran; Terri J Waller; Jason R B Dyck
AMPK signalling and the control of substrate use in the heart.
Molecular and cellular endocrinology 2013;366(2):180-93.
2013: Marie A Schroeder; Damian J Tyler; Graham A Wright; Jennifer Barry; Albert P Chen; Kieran Clarke; Kim A Connelly; Jason R B Dyck; Yiping Gu; Xudong Hu; Angus Z Lau; Jeevan Nagendran; Charles H Cunningham
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
European journal of heart failure 2013;15(2):130-40.
2013: Benjamin Lauzier; Clemence MERLEN; Marie-Eve Rivard; Fanny Vaillant; Bruce G Allen; Bertrand Bouchard; John C Chatham; Vernon W Dolinsky; Jason R B Dyck; Roselle Gélinas; Francois Labarthe; Christine Des Rosiers
Metabolic effects of glutamine on the heart: anaplerosis versus the hexosamine biosynthetic pathway.
Journal of molecular and cellular cardiology 2013;55():92-100.
2013: Petra C Kienesberger; Jeevan Nagendran; THOMAS CHACKO PULINILKUNNIL; Jason R B Dyck
Myocardial triacylglycerol metabolism.
Journal of molecular and cellular cardiology 2013;55():101-10.
2013: Dukgyu Lee; Peter E Light; Gary D Lopaschuk; Kimitoshi Nakamura; Barbara E Nickel; Tatsujiro Oka; Michal Opas; Sylvia Papp; Alison Robinson; Wattamon Srisakuldee; Jason R B Dyck; Beth Hunter; Elissavet Kardami; Marek Michalak
Calreticulin induces dilated cardiomyopathy.
PloS one 2013;8(2):e56387.
2013: Brent A McLean; Jason R B Dyck; Petra C Kienesberger; Grant Masson; Wang Wang; Pavel Zhabyeyev; Gavin Y Oudit
Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling.
Journal of molecular and cellular cardiology 2013;54():9-18.
2013: Andrew N Carley; Jason R B Dyck; Natasha Hausler Banke; Jian Bi; J Michael O'Donnell; Xuerong Wang; E Douglas Lewandowski
Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36.
Journal of lipid research 2013;54(1):97-106.
2012: Brittany F Brown; Jason R B Dyck; Anita Quon; Joseph R Casey
Carbonic anhydrase II promotes cardiomyocyte hypertrophy.
Canadian journal of physiology and pharmacology 2012;90(12):1599-610.
2012: Jay H Chung; Vincent Manganiello; Jason R B Dyck
Resveratrol as a calorie restriction mimetic: therapeutic implications.
Trends in cell biology 2012;22(10):546-54.
2012: Miranda M Y Sung; Jason R B Dyck
Age-related cardiovascular disease and the beneficial effects of calorie restriction.
Heart failure reviews 2012;17(4-5):707-19.
2012: Christian Rueda-Clausen; Vernon W Dolinsky; Jason R B Dyck; Jude S Morton; Sandra T Davidge
Synergistic effects of prenatal hypoxia and postnatal high-fat diet in the development of cardiovascular pathology in young rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;303(4):R418-26.
2012: Lee W Jones; Christopher D Lascola; Elizabeth M Masko; Jeevan Nagendran; Erik Nelson; Michael Pollak; Martin E Young; Jodi Antonelli; Allison S Betof; Gloria Broadwater; Rajesh C Dash; Mark W Dewhirst; Jason R B Dyck; Diane Fels; Catherine T Flores; Stephen J Freedland
Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;113(2):263-72.
2012: Danna M Breen; Paresh Dandona; Vernon W Dolinsky; Jason R B Dyck; Husam Ghanim; June Guo; Scott P Heximer; Margaret Mroziewicz; Evangelia L Tsiani; Hangjun Zhang; Michelle P Bendeck; Adria Giacca
Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism.
Atherosclerosis 2012;222(2):375-81.
2012: Vernon W Dolinsky; Michael P Czubryt; Tessa Gordon; Mark Haykowsky; Kelvin E Jones; Robinder S Sidhu; Jason R B Dyck
Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats.
The Journal of physiology 2012;590(Pt 11):2783-99.
2012: John R Ussher; Cory S Wagg; Wei Wang; Tatsujiro Oka; Victor Samokhvalov; Alexander S Clanachan; Jason R B Dyck; Manoj Gandhi; Robert A Harris; Jagdip S Jaswal; Wendy Keung; Gary D Lopaschuk
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.
Cardiovascular research 2012;94(2):359-69.
2012: Petra C Kienesberger; Peter E Light; Jeevan Nagendran; Gavin Y Oudit; THOMAS CHACKO PULINILKUNNIL; Miranda M Y Sung; Martin E Young; Rudolf Zechner; Guenter Haemmerle; Erin E Kershaw; Jason R B Dyck
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.
Molecular and cellular biology 2012;32(4):740-50.
2011: Vernon W Dolinsky; Jason R B Dyck
Calorie restriction and resveratrol in cardiovascular health and disease.
Biochimica et biophysica acta 2011;1812(11):1477-89.
2011: Vernon W Dolinsky; Jude S Morton; Christian F Rueda-Clausen; Sandra T Davidge; Jason R B Dyck
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted.
Diabetes 2011;60(9):2274-84.
2011: Benjamin Lauzier; Clemence MERLEN; Fanny Vaillant; Janie McDuff; Bertrand Bouchard; Pauline C Beguin; Vernon W Dolinsky; Sylvain Foisy; Louis R Villeneuve; François Labarthe; Jason R B Dyck; Bruce G Allen; Guy Charron; Christine Des Rosiers
Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart.
Journal of molecular and cellular cardiology 2011;51(1):99-108.
2011: Miranda M Y Sung; Debby P Y Koonen; Carrie-Lynn M Soltys; René L Jacobs; Maria Febbraio; Jason R B Dyck
Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction.
Journal of molecular medicine (Berlin, Germany) 2011;89(5):459-69.
2011: David J Durgan; Ju-Yun Tsai; Maximiliano H Grenett; Betty M Pat; William F Ratcliffe; Carolina Villegas-Montoya; Merissa E Garvey; Jeevan Nagendran; Jason R B Dyck; Molly S Bray; Karen L Gamble; Jeffrey M Gimble; Martin E Young
Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice.
Chronobiology international 2011;28(3):187-203.
2011: Laura K Cole; Vernon W Dolinsky; Jason R B Dyck; Dennis E Vance
Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice.
Circulation research 2011;108(6):686-94.
2011: Miranda M Y Sung; Carrie-Lynn M Soltys; Grant Masson; Jamie J Boisvenue; Jason R B Dyck
Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice.
Journal of molecular medicine (Berlin, Germany) 2011;89(3):291-302.
2011: Christian F Rueda-Clausen; Vernon W Dolinsky; Jude S Morton; Spencer D Proctor; Jason R B Dyck; Sandra T Davidge
Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome.
Diabetes 2011;60(2):507-16.
2011: Rajesh S Alphonse; Arul Vadivel; Lavinia Coltan; Farah Eaton; Amy J Barr; Jason R B Dyck; Bernard Thébaud
Activation of Akt protects alveoli from neonatal oxygen-induced lung injury.
American journal of respiratory cell and molecular biology 2011;44(2):146-54.
2010: Vernon W Dolinsky; Jude S Morton; Tatsujiro Oka; Isabelle Robillard-Frayne; Mariel Bagdan; Gary D Lopaschuk; Christine Des Rosiers; Kenneth Walsh; Sandra T Davidge; Jason R B Dyck
Calorie restriction prevents hypertension and cardiac hypertrophy in the spontaneously hypertensive rat.
Hypertension 2010;56(3):412-21.
2010: Gopinath Sutendra; Sebastien Bonnet; Gael Rochefort; Alois Haromy; Karalyn D Folmes; Gary D Lopaschuk; Jason R B Dyck; Evangelos D Michelakis
Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.
Science translational medicine 2010;2(44):44ra58.
2010: René L Jacobs; Yang Zhao; Debby P Y Koonen; Torunn Sletten; Brian Su; Susanne Lingrell; Guoqing Cao; David A Peake; Ming-Shang Kuo; Spencer D Proctor; Brian P Kennedy; Jason R B Dyck; Dennis E Vance
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
The Journal of biological chemistry 2010;285(29):22403-13.
2010: Kevin S C Hamming; Daniel Soliman; Nicola J Webster; Gavin J Searle; Laura C Matemisz; David A Liknes; Xiao-Qing Dai; THOMAS CHACKO PULINILKUNNIL; Michael J Riedel; Jason R B Dyck; Patrick E MacDonald; Peter E Light
Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.
Diabetes 2010;59(7):1686-93.
2010: Stephen L Archer; Glenn Marsboom; Gene H Kim; Hannah J Zhang; Peter P. Toth; Eric C Svensson; Jason R B Dyck; Mardi Gomberg-Maitland; Bernard Thébaud; Aliya N Husain; Nicole Cipriani; Jalees Rehman
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Circulation 2010;121(24):2661-71.
2010: Debby P Y Koonen; Miranda M Y Sung; Cindy K C Kao; Vernon W Dolinsky; Timothy R Koves; Olga Ilkayeva; René L Jacobs; Dennis E Vance; Peter E Light; Deborah M Muoio; Maria Febbraio; Jason R B Dyck
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Diabetes 2010;59(6):1366-75.
2010: David N Brindley; Bernard P C Kok; Petra C Kienesberger; Richard Lehner; Jason R B Dyck
Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E897-908.
2010: Enhui Wei; Yassine Ben Ali; James Lyon; Huajin Wang; Randy Nelson; Vernon W Dolinsky; Jason R B Dyck; Grant Mitchell; Gregory S Korbutt; Richard Lehner
Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure.
Cell metabolism 2010;11(3):183-93.
2010: David J Durgan; THOMAS CHACKO PULINILKUNNIL; Carolina Villegas-Montoya; Merissa E Garvey; Nikolaos G Frangogiannis; Lloyd H Michael; Chi-Wing Chow; Jason R B Dyck; Martin E Young
Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock.
Circulation research 2010;106(3):546-50.
2010: Ju-Yun Tsai; Petra C Kienesberger; THOMAS CHACKO PULINILKUNNIL; Mary H Sailors; David J Durgan; Carolina Villegas-Montoya; Anil Jahoor; Raquel Gonzalez; Merissa E Garvey; Brandon Boland; Zachary Blasier; Tracy A McElfresh; Vijayalakshmi Nannegari; Chi-Wing Chow; William C Heird; Margaret P Chandler; Jason R B Dyck; Molly S Bray; Martin E Young
Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock.
The Journal of biological chemistry 2010;285(5):2918-29.
2009: Yasumasa Ikeda; Kaori Sato; David R Pimentel; Flora Sam; Reuben J Shaw; Jason R B Dyck; Kenneth Walsh
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction.
The Journal of biological chemistry 2009;284(51):35839-49.
2009: Karalyn D Folmes; Anita Y M Chan; Debby P Y Koonen; THOMAS CHACKO PULINILKUNNIL; István Baczkó; Beth E Hunter; Stephanie Thorn; Michael F Allard; Robert Roberts; Michael H Gollob; Peter E Light; Jason R B Dyck
Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen.
Circulation. Cardiovascular genetics 2009;2(5):457-66.
2009: Sebastien Bonnet; Roxane Paulin; Gopinath Sutendra; Peter Dromparis; Melanie Roy; Kristalee O Watson; Jayan Nagendran; Alois Haromy; Jason R B Dyck; Evangelos D Michelakis
Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.
Circulation 2009;120(13):1231-40.
2009: John R Ussher; Timothy R Koves; Jagdip S Jaswal; Liyan Zhang; Olga Ilkayeva; Jason R B Dyck; Deborah M Muoio; Gary D Lopaschuk
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
Diabetes 2009;58(8):1766-75.
2009: Ramesh Saeedi; Varun V Saran; Sherry S Y Wu; Erika S Kume; Kim Paulson; Annie P K Chan; Hannah L Parsons; Richard B Wambolt; Jason R B Dyck; Roger Brownsey; Michael F Allard
AMP-activated protein kinase influences metabolic remodeling in H9c2 cells hypertrophied by arginine vasopressin.
American journal of physiology. Heart and circulatory physiology 2009;296(6):H1822-32.
2009: Vernon W Dolinsky; Anita Y M Chan; Isabelle Robillard Frayne; Peter E Light; Christine Des Rosiers; Jason R B Dyck
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.
Circulation 2009;119(12):1643-52.
2008: Anita Y M Chan; Vernon W Dolinsky; Carrie-Lynn M Soltys; Benoit Viollet; Shairaz Baksh; Peter E Light; Jason R B Dyck
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
The Journal of biological chemistry 2008;283(35):24194-201.
2008: Jayan Nagendran; Vikram Gurtu; David Z Fu; Jason R B Dyck; Alois Haromy; David B Ross; Ivan M Rebeyka; Evangelos D Michelakis
A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.
The Journal of thoracic and cardiovascular surgery 2008;136(1):168-78, 178.e1-3.
2008: Ramesh Saeedi; Hannah L Parsons; Richard B Wambolt; Kim Paulson; Vijay Sharma; Jason R B Dyck; Roger Brownsey; Michael F Allard
Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2497-506.
2008: Molly S Bray; Chad A Shaw; Michael W S Moore; Rodrigo A P Garcia; Melissa Zanquetta; David J Durgan; William J Jeong; Ju-Yun Tsai; Heiko Bugger; Dongfang Zhang; Andreas Rohrwasser; Julie H Rennison; Jason R B Dyck; Sheldon E Litwin; Paul E Hardin; Chi-Wing Chow; Margaret P Chandler; E Dale Abel; Martin E Young
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H1036-47.
2008: Timothy R Koves; John R Ussher; Robert C Noland; Dorothy H Slentz; Merrie Mosedale; Olga Ilkayeva; James R Bain; Robert Stevens; Jason R B Dyck; Christopher B Newgard; Gary D Lopaschuk; Deborah M Muoio
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
Cell metabolism 2008;7(1):45-56.
2007: Jason R B Dyck
The ischemic heart: starving to stimulate the adiponectin-AMPK signaling axis.
Circulation 2007;116(24):2779-81.
2007: Karalyn D Folmes; Lee A Witters; Michael F Allard; Martin E Young; Jason R B Dyck
The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3456-64.
2007: Debby P Y Koonen; René L Jacobs; Maria Febbraio; Martin E Young; Carrie-Lynn M Soltys; Huy Ong; Dennis E Vance; Jason R B Dyck
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity.
Diabetes 2007;56(12):2863-71.
2007: Debby P Y Koonen; Maria Febbraio; Sebastien Bonnet; Jayan Nagendran; Martin E Young; Evangelos D Michelakis; Jason R B Dyck
CD36 expression contributes to age-induced cardiomyopathy in mice.
Circulation 2007;116(19):2139-47.
2007: David J Durgan; Michael W S Moore; Ngan P Ha; Oluwaseun Egbejimi; Anna Fields; Uchenna Mbawuike; Anu Egbejimi; Chad A Shaw; Molly S Bray; Vijayalakshmi Nannegari; Diane L Hickson-Bick; William C Heird; Jason R B Dyck; Margaret P Chandler; Martin E Young
Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2385-93.
2007: Maya Khairallah; Ramzi Khairallah; Martin E Young; Jason R B Dyck; Basil J Petrof; Christine Des Rosiers
Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy.
Journal of molecular and cellular cardiology 2007;43(2):119-29.
2007: Jagdip S Jaswal; Manoj Gandhi; Barry A Finegan; Jason R B Dyck; Alexander S Clanachan
Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.
American journal of physiology. Heart and circulatory physiology 2007;293(2):H1107-14.
2007: Jayan Nagendran; Stephen L Archer; Daniel Soliman; Vikram Gurtu; Rohit Moudgil; Alois Haromy; Chantal St Aubin; Linda Webster; Ivan M Rebeyka; David B Ross; Peter E Light; Jason R B Dyck; Evangelos D Michelakis
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Circulation 2007;116(3):238-48.
2007: Jagdip S Jaswal; Manoj Gandhi; Barry A Finegan; Jason R B Dyck; Alexander S Clanachan
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1978-85.
2007: Anna A Noga; Carrie-Lynn M Soltys; Amy J Barr; Suzanne Kovacic; Gary D Lopaschuk; Jason R B Dyck
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.
American journal of physiology. Heart and circulatory physiology 2007;292(3):H1460-9.
2007: René L Jacobs; Susanne Lingrell; Jason R B Dyck; Dennis E Vance
Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation.
The Journal of biological chemistry 2007;282(7):4516-23.
2006: Vernon W Dolinsky; Jason R B Dyck
Role of AMP-activated protein kinase in healthy and diseased hearts.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H2557-69.
2006: Min Xie; Dou Zhang; Jason R B Dyck; Yi Li; Hui Zhang; Masae Morishima; Douglas L Mann; George E Taffet; Antonio Baldini; Dirar S Khoury; Michael D Schneider
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17378-83.
2006: Jason R B Dyck; Teresa A Hopkins; Sebastien Bonnet; Evangelos D Michelakis; Martin E Young; Miho Watanabe; Yosuke Kawase; Kou-ichi Jishage; Gary D Lopaschuk
Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.
Circulation 2006;114(16):1721-8.
2006: Michael J Riedel; István Baczkó; Gavin J Searle; Nicola Webster; Matthew Fercho; Lynn Jones; Jessica Lang; Jonathan Lytton; Jason R B Dyck; Peter E Light
Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.
The EMBO journal 2006;25(19):4605-14.
2006: Jagdip S Jaswal; Manoj Gandhi; Barry A Finegan; Jason R B Dyck; Alexander S Clanachan
Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase.
American journal of physiology. Heart and circulatory physiology 2006;291(4):H1883-92.
2006: Renaud Dentin; Fadila Benhamed; Isabelle Hainault; Véronique Fauveau; Fabienne Foufelle; Jason R B Dyck; JEAN R GIRARD; Catherine Postic
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.
Diabetes 2006;55(8):2159-70.
2006: Jie-Fei Cheng; Yujin Huang; Richard Penuliar; Masahiro Nishimoto; Larry Liu; Thomas Arrhenius; Guang Yang; Eoin O'leary; Miguel Barbosa; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.
Journal of medicinal chemistry 2006;49(14):4055-8.
2006: Jason R B Dyck; Gary D Lopaschuk
AMPK alterations in cardiac physiology and pathology: enemy or ally?
The Journal of physiology 2006;574(Pt 1):95-112.
2006: Jie-Fei Cheng; Chi Ching Mak; Yujin Huang; Richard Penuliar; Masahiro Nishimoto; Lin Zhang; Mi Chen; David Wallace; Thomas Arrhenius; Donald Chu; Guang Yang; Miguel Barbosa; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(13):3484-8.
2006: Carrie-Lynn M Soltys; Suzanne Kovacic; Jason R B Dyck
Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity.
American journal of physiology. Heart and circulatory physiology 2006;290(6):H2472-9.
2006: David J Durgan; Justin K Smith; Margaret A Hotze; Oluwaseun Egbejimi; Karalyn D Cuthbert; Vlad G Zaha; Jason R B Dyck; E Dale Abel; Martin E Young
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.
American journal of physiology. Heart and circulatory physiology 2006;290(6):H2480-97.
2006: Jie-Fei Cheng; Mi Chen; David Wallace; Souvothy Tith; Masayuki Haramura; Bin Liu; Chi Ching Mak; Thomas Arrhenius; Sean Reily; Steven Brown; Vicki Thorn; Charles Harmon; Rick Barr; Jason R B Dyck; Gary D Lopaschuk; Alex M Nadzan
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Journal of medicinal chemistry 2006;49(5):1517-25.
2005: Karalyn D Cuthbert; Jason R B Dyck
Malonyl-CoA decarboxylase is a major regulator of myocardial fatty acid oxidation.
Current hypertension reports 2005;7(6):407-11.
2005: William C Stanley; Eric E Morgan; Hazel Huang; Tracy A McElfresh; Joseph P Sterk; Isidore C Okere; Margaret P Chandler; Jiefei Cheng; Jason R B Dyck; Gary D Lopaschuk
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2304-9.
2005: Kristen L King; Isidore C Okere; Naveen Sharma; Jason R B Dyck; Aneta E Reszko; Tracy A McElfresh; Janos Kerner; Margaret P Chandler; Gary D Lopaschuk; William C Stanley
Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1033-7.
2005: Rogayah Carroll; Andrew N Carley; Jason R B Dyck; David L Severson
Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts.
American journal of physiology. Endocrinology and metabolism 2005;288(5):E900-6.
2005: Anita Y M Chan; Jason R B Dyck
Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy.
Canadian journal of physiology and pharmacology 2005;83(1):24-8.
2004: M Sean McMurtry; Sebastien Bonnet; Xichen Wu; Jason R B Dyck; Alois Haromy; Kyoko Hashimoto; Evangelos D Michelakis
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.
Circulation research 2004;95(8):830-40.
2004: Bernard Thébaud; Evangelos D Michelakis; Xi-Chen Wu; Rohit Moudgil; Michael Kuzyk; Jason R B Dyck; Gwyneth Harry; Kyoko Hashimoto; Alois Haromy; Ivan M Rebeyka; Stephen L Archer
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.
Circulation 2004;110(11):1372-9.
2004: Aneta E Reszko; Takhar Kasumov; France David; Katherine R Thomas; Kathryn A Jobbins; Jie-Fei Cheng; Gary D Lopaschuk; Jason R B Dyck; Mireya Diaz; Christine Des Rosiers; William C Stanley; Henri Brunengraber
Regulation of malonyl-CoA concentration and turnover in the normal heart.
The Journal of biological chemistry 2004;279(33):34298-301.
2004: Anita Y M Chan; Carrie-Lynn M Soltys; Martin E Young; Christopher G Proud; Jason R B Dyck
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.
The Journal of biological chemistry 2004;279(31):32771-9.
2004: Nandakumar Sambandam; Michael Steinmetz; Angel Chu; Judith Y Altarejos; Jason R B Dyck; Gary D Lopaschuk
Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.
European journal of biochemistry / FEBS 2004;271(13):2831-40.
2004: Jason R B Dyck; Jie-Fei Cheng; William C Stanley; Rick Barr; Margaret P Chandler; Steven Brown; David Wallace; Thomas Arrhenius; Charles Harmon; Guang Yang; Alex M Nadzan; Gary D Lopaschuk
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
Circulation research 2004;94(9):e78-84.
2004: Demin Zhou; Phoebe Yuen; Donald Chu; Vicki Thon; Steve McConnell; Steven Brown; Andria Tsang; Michael Pena; Anna Russell; Jie-Fei Cheng; Alex M Nadzan; Miguel S Barbosa; Jason R B Dyck; Gary D Lopaschuk; Guang Yang
Expression, purification, and characterization of human malonyl-CoA decarboxylase.
Protein expression and purification 2004;34(2):261-9.
2004: Michael Kuang; Maria Febbraio; Cory Wagg; Gary D Lopaschuk; Jason R B Dyck
Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia.
Circulation 2004;109(12):1550-7.
2004: GuoQi Teng; Xiang Zhao; James C Cross; Pin Li; James P Lees-Miller; Jiqing Guo; Jason R B Dyck; Henry J Duff
Prolonged repolarization and triggered activity induced by adenoviral expression of HERG N629D in cardiomyocytes derived from stem cells.
Cardiovascular research 2004;61(2):268-77.
2003: Suzanne Kovacic; Carrie-Lynn M Soltys; Amy J Barr; Ichiro Shiojima; Kenneth Walsh; Jason R B Dyck
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart.
The Journal of biological chemistry 2003;278(41):39422-7.
2003: Gary D Lopaschuk; Rick Barr; Panakkezhum D Thomas; Jason R B Dyck
Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.
Circulation research 2003;93(3):e33-7.
2003: Teresa A Hopkins; Mary C Sugden; Mark J Holness; Ray Kozak; Jason R B Dyck; Gary D Lopaschuk
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H270-6.
2003: Zlatko I Pozeg; Evangelos D Michelakis; M Sean McMurtry; Bernard Thébaud; Xi-Chen Wu; Jason R B Dyck; Kyoko Hashimoto; Shaohua Wang; Rohit Moudgil; Gwyneth Harry; Richard Sultanian; Arvind Koshal; Stephen L Archer
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
Circulation 2003;107(15):2037-44.
2003: Peter E Light; Catriona H R Wallace; Jason R B Dyck
Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes.
Circulation 2003;107(15):1962-5.
2003: Teresa A Hopkins; Jason R B Dyck; Gary D Lopaschuk
AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart.
Biochemical Society transactions 2003;31(Pt 1):207-12.
2003: Arzu Onay-Besikci; Fiona M Campbell; Teresa A Hopkins; Jason R B Dyck; Gary D Lopaschuk; Arzu Onay Besikci
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H283-9.
2002: Evangelos D Michelakis; Ivan M Rebeyka; XiChen Wu; Ali Nsair; Bernard Thébaud; Kyoko Hashimoto; Jason R B Dyck; Alois Haromy; Gwyneth Harry; Amy Barr; Stephen L Archer
O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.
Circulation research 2002;91(6):478-86.
2002: Wenjie Wang; Costas J Schulze; Wilma L Suarez-Pinzon; Jason R B Dyck; Grzegorz Sawicki; Richard Schulz
Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury.
Circulation 2002;106(12):1543-9.
2002: Jason R B Dyck; Gary D Lopaschuk
Malonyl CoA control of fatty acid oxidation in the ischemic heart.
Journal of molecular and cellular cardiology 2002;34(9):1099-109.
2002: Carrie-Lynn M Soltys; Lori Buchholz; Manoj Gandhi; Alexander S Clanachan; Kenneth Walsh; Jason R B Dyck
Phosphorylation of cardiac protein kinase B is regulated by palmitate.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H1056-64.
2002: Yi Xu; Dinender Kumar; Jason R B Dyck; William R Ford; Alexander S Clanachan; Gary D Lopaschuk; Bodh I Jugdutt
AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1206-15.
2002: Fiona M Campbell; Ray Kozak; Alese Wagner; Judith Y Altarejos; Jason R B Dyck; Darrell D Belke; David L Severson; Daniel P Kelly; Gary D Lopaschuk
A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase.
The Journal of biological chemistry 2002;277(6):4098-103.
2002: Evangelos D Michelakis; M Sean McMurtry; Xi-Chen Wu; Jason R B Dyck; Rohit Moudgil; Teresa A Hopkins; Gary D Lopaschuk; Lakshmi Puttagunta; Ross Waite; Stephen L Archer
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Circulation 2002;105(2):244-50.
2001: Evangelos D Michelakis; Jason R B Dyck; M Sean McMurtry; Shaohua Wang; Xi-Chen Wu; Rohit Moudgil; Kyoko Hashimoto; Lakshmi Puttagunta; Stephen L Archer
Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models.
Advances in experimental medicine and biology 2001;502():401-18.
2000: Jason R B Dyck; Luc G Berthiaume; Panakkezhum D Thomas; PF Kantor; Amy J Barr; Rick Barr; D Singh; Teresa A Hopkins; N Voilley; Marc Prentki; Gary D Lopaschuk
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism.
The Biochemical journal 2000;350 Pt 2():599-608.
2000: Sharon E Johnatty; Jason R B Dyck; Lloyd H Michael; Eric N Olson; Maha Abdellatif
Identification of genes regulated during mechanical load-induced cardiac hypertrophy.
Journal of molecular and cellular cardiology 2000;32(5):805-15.
1999: PF Kantor; Jason R B Dyck; Gary D Lopaschuk
Fatty acid oxidation in the reperfused ischemic heart.
The American journal of the medical sciences 1999;318(1):3-14.
1999: N Voilley; Raphael Roduit; R Vicaretti; C Bonny; Gerard Waeber; Jason R B Dyck; Gary D Lopaschuk; Marc Prentki
Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase.
The Biochemical journal 1999;340 ( Pt 1)():213-7.
1999: Jason R B Dyck; N Kudo; Amy J Barr; S P Davies; D G Hardie; Gary D Lopaschuk
Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase.
European journal of biochemistry / FEBS 1999;262(1):184-90.
1998: Jason R B Dyck; Amy J Barr; RL Barr; Pappachan Kolattukudy; Gary D Lopaschuk
Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation.
The American journal of physiology 1998;275(6 Pt 2):H2122-9.
1998: Jason R B Dyck; Gary D Lopaschuk
Glucose metabolism, H+ production and Na+/H+-exchanger mRNA levels in ischemic hearts from diabetic rats.
Molecular and cellular biochemistry 1998;180(1-2):85-93.
1996: Huajin Wang; D Singh; W Yang; Jason R B Dyck; Larry Fliegel
Structure and analysis of the mouse Na+/H+ exchanger (NHE1) gene: homology and conservation of splice sites.
Molecular and cellular biochemistry 1996;165(2):155-9.
1996: W Yang; Jason R B Dyck; Larry Fliegel
Regulation of NHE1 expression in L6 muscle cells.
Biochimica et biophysica acta 1996;1306(1):107-13.
1996: W Yang; Jason R B Dyck; Huajin Wang; Larry Fliegel
Regulation of NHE-1 promoter in mammalian myocardium.
The American journal of physiology 1996;270(1 Pt 2):H259-66.
1995: Jason R B Dyck; Larry Fliegel
Specific activation of the Na+/H+ exchanger gene during neuronal differentiation of embryonal carcinoma cells.
The Journal of biological chemistry 1995;270(18):10420-7.
1995: Jason R B Dyck; Thane G Maddaford; Grant N Pierce; Larry Fliegel
Induction of expression of the sodium-hydrogen exchanger in rat myocardium.
Cardiovascular research 1995;29(2):203-8.
1995: Larry Fliegel; Jason R B Dyck
Molecular biology of the cardiac sodium/hydrogen exchanger.
Cardiovascular research 1995;29(2):155-9.
1995: Jason R B Dyck; N L Silva; Larry Fliegel
Activation of the Na+/H+ exchanger gene by the transcription factor AP-2.
The Journal of biological chemistry 1995;270(3):1375-81.
1993: Larry Fliegel; Jason R B Dyck; Huajin Wang; C Fong; R S Haworth
Cloning and analysis of the human myocardial Na+/H+ exchanger.
Molecular and cellular biochemistry 1993;125(2):137-43.
1993: Larry Fliegel; R S Haworth; Jason R B Dyck
Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular size.
The Biochemical journal 1993;289 ( Pt 1)():101-7.
1992: Jason R B Dyck; Gary D Lopaschuk; Larry Fliegel
Identification of a small Na+/H+ exchanger-like message in the rabbit myocardium.
FEBS letters 1992;310(3):255-9.