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David Dyment

Research Profile

Disorders

Multiple Sclerosis

Physiology

Chemicals & Drugs

Geographic Areas

Canada

Genes & Molecular Sequences

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Concepts & Ideas

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Publications

TOP 3
Danielle C Lynch; Jacques L Michaud; Sarah M Nikkel; Jillian S Parboosingh; Carlos A Bacino; Francois P Bernier; Philippe Campeau; David A Dyment; Lijia Huang; Didier Lacombe; Brendan Lee; A Micheil Innes
Identification of novel mutations confirms Pde4d as a major gene causing acrodysostosis.
David A Dyment; George C Ebers; Pierre Lepage; Matthew R Lincoln; Alexandre Montpetit; Julia M Morahan; Katie M E Morrison; zameel cader; Michael J Chao; Gabriele C De Luca; Giulio Disanto; A Dessa Sadovnick; Sreeram V Ramagopalan
Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene.
Sreeram V Ramagopalan; David A Dyment; George C Ebers; C Guimond; Irene M L Yee; A Dessa Sadovnick
Early life child exposure and the risk of multiple sclerosis: a population based study.

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All Publications

2013: Danielle C Lynch; Jacques L Michaud; Sarah M Nikkel; Jillian S Parboosingh; Carlos A Bacino; Francois P Bernier; Philippe Campeau; David A Dyment; Lijia Huang; Didier Lacombe; Brendan Lee; A Micheil Innes
Identification of novel mutations confirms Pde4d as a major gene causing acrodysostosis.
Human mutation 2013;34(1):97-102.
2012: David A Dyment; George C Ebers; Pierre Lepage; Matthew R Lincoln; Alexandre Montpetit; Julia M Morahan; Katie M E Morrison; zameel cader; Michael J Chao; Gabriele C De Luca; Giulio Disanto; A Dessa Sadovnick; Sreeram V Ramagopalan
Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene.
Neurology 2012;79(5):406-11.
2011: Sreeram V Ramagopalan; David A Dyment; George C Ebers; C Guimond; Irene M L Yee; A Dessa Sadovnick
Early life child exposure and the risk of multiple sclerosis: a population based study.
Journal of the neurological sciences 2011;307(1-2):162-3.
2011: Michael J Chao; David A Dyment; Matthew R Lincoln; Sreeram V Ramagopalan; George C Ebers
HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Neurology 2011;77(6):602; author reply 602-3.
2011: Michael J Chao; Sreeram V Ramagopalan; B M Herrera; Sarah M Orton; L Handunnetthi; Matthew R Lincoln; David A Dyment; A Dessa Sadovnick; George C Ebers
MHC transmission: insights into gender bias in MS susceptibility.
Neurology 2011;76(3):242-6.
2011: Sreeram Ramagopalan; David A Dyment; Rachel Farrell; Noriko Isobe
Multiple sclerosis.
Autoimmune diseases 2011;2011():248758.
2011: Sreeram V Ramagopalan; David A Dyment
What is Next for the Genetics of Multiple Sclerosis?
Autoimmune diseases 2011;2011():519450.
2010: Sreeram V Ramagopalan; David A Dyment; Colleen Guimond; Sarah-Michelle Orton; Irene M Yee; George C Ebers; A Dessa Sadovnick
Childhood cow's milk allergy and the risk of multiple sclerosis: a population based study.
Journal of the neurological sciences 2010;291(1-2):86-8.
2010: C Guimond; David A Dyment; Sreeram V Ramagopalan; Gavin Giovannoni; Maria Criscuoli; Irene M Yee; George C Ebers; A Dessa Sadovnick
Prevalence of MS in Iranian immigrants to British Columbia, Canada.
Journal of neurology 2010;257(4):667-8.
2010: Sreeram V Ramagopalan; David A Dyment; Lahiru Handunnetthi; George P Rice; George C Ebers
A genome-wide scan of male sexual orientation.
Journal of human genetics 2010;55(2):131-2.
2010: Sreeram V Ramagopalan; David A Dyment; Colleen Guimond; Sarah M Orton; Irene M Yee; George C Ebers; A Dessa Sadovnick
Mother-child blood group incompatibility and the risk of multiple sclerosis.
Journal of neurology 2010;257(2):286-7.
2010: Sreeram V Ramagopalan; C Guimond; Maria Criscuoli; David A Dyment; Sarah-Michelle Orton; Irene M L Yee; George C Ebers; Dessa Sadovnick
Congenital abnormalities and multiple sclerosis.
BMC neurology 2010;10():115.
2010: Sreeram V Ramagopalan; David A Dyment; Colleen Guimond; Irene M L Yee; George C Ebers; A Dessa Sadovnick
No effect of parental age on risk of multiple sclerosis: a population-based study.
Neuroepidemiology 2010;34(2):106-9.
2010: Sarah M Orton; Sreeram V Ramagopalan; D Brocklebank; B M Herrera; David A Dyment; Irene M L Yee; A Dessa Sadovnick; George C Ebers
Effect of immigration on multiple sclerosis sex ratio in Canada: the Canadian Collaborative Study.
Journal of neurology, neurosurgery, and psychiatry 2010;81(1):31-6.
2009: Sreeram V Ramagopalan; Jenny Link; J K Byrnes; David A Dyment; G Giovannoni; R Q Hintzen; E Sundqvist; I Kockum; C Smestad; B A Lie; H F Harbo; L Padyukov; L Alfredsson; T Olsson; A Dessa Sadovnick; J Hillert; George C Ebers
HLA-DRB1 and month of birth in multiple sclerosis.
Neurology 2009;73(24):2107-11.
2009: Sreeram V Ramagopalan; Jake K Byrnes; David A Dyment; Colleen Guimond; Lahiru Handunnetthi; Giulio Disanto; Irene M Yee; George C Ebers; A Dessa Sadovnick
Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis.
Journal of human genetics 2009;54(9):547-9.
2009: Sreeram V Ramagopalan; Irene M L Yee; David A Dyment; Sarah M Orton; R A Marrie; A Dessa Sadovnick; George C Ebers
Parent-of-origin effect in multiple sclerosis: observations from interracial matings.
Neurology 2009;73(8):602-5.
2009: A Dessa Sadovnick; Irene M L Yee; C Guimond; Jacques Reis; David A Dyment; George C Ebers
Age of onset in concordant twins and other relative pairs with multiple sclerosis.
American journal of epidemiology 2009;170(3):289-96.
2009: M J D'Netto; H Ward; K M Morrison; Sreeram V Ramagopalan; David A Dyment; Gabriele C DeLuca; L Handunnetthi; A Dessa Sadovnick; George C Ebers
Risk alleles for multiple sclerosis in multiplex families.
Neurology 2009;72(23):1984-8.
2009: Matthew R Lincoln; Sreeram V Ramagopalan; Michael J Chao; blanca herrera; Gabriele C DeLuca; Sarah-Michelle Orton; David A Dyment; A Dessa Sadovnick; George C Ebers
Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7542-7.
2009: Sreeram V Ramagopalan; William Valdar; M Criscuoli; Gabriele C DeLuca; David A Dyment; S-M Orton; Irene M L Yee; George C Ebers; A Dessa Sadovnick
Age of puberty and the risk of multiple sclerosis: a population based study.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2009;16(3):342-7.
2009: Sreeram V Ramagopalan; Narelle J Maugeri; Lahiru Handunnetthi; Matthew R Lincoln; Sarah M Orton; David A Dyment; Gabriele C DeLuca; blanca herrera; Michael J Chao; A Dessa Sadovnick; George C Ebers; Julian C Knight
Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D.
PLoS genetics 2009;5(2):e1000369.
2009: Sreeram V Ramagopalan; William Valdar; David A Dyment; Gabriele C DeLuca; Irene M L Yee; Gavin Giovannoni; George C Ebers; A Dessa Sadovnick
Association of infectious mononucleosis with multiple sclerosis. A population-based study.
Neuroepidemiology 2009;32(4):257-62.
2008: Sreeram V Ramagopalan; David A Dyment; George C Ebers
Genetic epidemiology: the use of old and new tools for multiple sclerosis.
Trends in neurosciences 2008;31(12):645-52.
2008: Sreeram V Ramagopalan; Marko Cukjati; Maja Cernilec; Gabriele C DeLuca; David A Dyment; Alexandra Degenhardt; A Dessa Sadovnick; Vladka Curin Serbec; George C Ebers; Pierre Duquette
Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis.
Journal of neuroimmunology 2008;203(1):104-7.
2008: Michael J Chao; M C N M Barnardo; Matthew R Lincoln; Sreeram V Ramagopalan; blanca herrera; David A Dyment; Alexandre Montpetit; A Dessa Sadovnick; Julian C Knight; George C Ebers
HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13069-74.
2008: David A Dyment; M Zameel Cader; Anita Datta; S John Broxholme; Stacey Cherny; Cristen J Willer; Sreeram Ramagopalan; blanca herrera; Sarah M Orton; Michael Chao; A Dessa Sadovnick; Mary Hader; Walter Hader; George C Ebers
A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(4):467-72.
2008: Sreeram V Ramagopalan; David A Dyment; blanca herrera; Gabriele C DeLuca; Matthew R Lincoln; Sarah M Orton; Lahiru Handunnetthi; Michael J Chao; A Dessa Sadovnick; George C Ebers
Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis.
Journal of neuroimmunology 2008;196(1-2):170-2.
2008: David A Dyment; zameel cader; blanca herrera; Sreeram V Ramagopalan; Sarah M Orton; M Chao; Cristen J Willer; A Dessa Sadovnick; Neil Risch; George C Ebers
A genome scan in a single pedigree with a high prevalence of multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2008;79(2):158-62.
2008: Sreeram V Ramagopalan; Blanca M Herrera; William Valdar; David A Dyment; Sarah-Michelle Orton; Irene M L Yee; Maria Criscuoli; Kevin Atkins; George C Ebers; A Dessa Sadovnick
No effect of birth weight on the risk of multiple sclerosis. A population-based study.
Neuroepidemiology 2008;31(3):181-4.
2008: Sreeram V Ramagopalan; William Valdar; David A Dyment; Gabriele C DeLuca; Sarah M Orton; Irene M L Yee; Maria Criscuoli; George C Ebers; A Dessa Sadovnick
No effect of preterm birth on the risk of multiple sclerosis: a population based study.
BMC neurology 2008;8():30.
2008: Sreeram V Ramagopalan; David A Dyment; Katie M Morrison; blanca herrera; Gabriele C DeLuca; Matthew R Lincoln; Sarah M Orton; Lahiru Handunnetthi; Michael J Chao; A Dessa Sadovnick; George C Ebers
Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis.
BMC medical genetics 2008;9():63.
2008: Sreeram V Ramagopalan; blanca herrera; Jordana Tzenova Bell; David A Dyment; Gabriele C DeLuca; Matthew R Lincoln; Sarah M Orton; Michael J Chao; A Dessa Sadovnick; George C Ebers
Parental transmission of HLA-DRB1*15 in multiple sclerosis.
Human genetics 2008;122(6):661-3.
2007: Gabriele C DeLuca; Sreeram V Ramagopalan; blanca herrera; David A Dyment; Matthew R Lincoln; Alexandre Montpetit; Maura Pugliatti; M C N M Barnardo; Neil J Risch; A Dessa Sadovnick; M Chao; Stefano Sotgiu; Thomas J Hudson; George C Ebers
An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20896-901.
2007: David A Dyment; George C Ebers
Microsatellites and genome scans-- a GAMES postscript.
Journal of neuroimmunology 2007;190(1-2):5-7.
2007: Sreeram V Ramagopalan; Andrew P Morris; David A Dyment; blanca herrera; Gabriele C DeLuca; Matthew R Lincoln; Sarah M Orton; Michael J Chao; A Dessa Sadovnick; George C Ebers
The inheritance of resistance alleles in multiple sclerosis.
PLoS genetics 2007;3(9):1607-13.
2007: Gabriele C DeLuca; Sreeram V Ramagopalan; zameel cader; David A Dyment; blanca herrera; Sarah M Orton; A Degenhardt; Maura Pugliatti; A Dessa Sadovnick; Stefano Sotgiu; George C Ebers
The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.
Journal of neurology 2007;254(9):1221-6.
2007: Michael J Chao; M C N M Barnardo; Guang-Zhi Lui; Matthew R Lincoln; Sreeram V Ramagopalan; blanca herrera; David A Dyment; A Dessa Sadovnick; George C Ebers
Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.
Human molecular genetics 2007;16(16):1951-8.
2007: blanca herrera; zameel cader; David A Dyment; Jordana Tzenova Bell; Gabriele C DeLuca; Cristen J Willer; Matthew R Lincoln; Sreeram V Ramagopalan; M Chao; Sarah M Orton; A Dessa Sadovnick; George C Ebers
Multiple sclerosis susceptibility and the X chromosome.
Multiple sclerosis (Houndmills, Basingstoke, England) 2007;13(7):856-64.
2007: Sreeram V Ramagopalan; David A Dyment; William Valdar; blanca herrera; Maria Criscuoli; Irene M L Yee; A Dessa Sadovnick; George C Ebers
Autoimmune disease in families with multiple sclerosis: a population-based study.
Lancet neurology 2007;6(7):604-10.
2007: Sreeram V Ramagopalan; Gabriele C DeLuca; Katie M E Morrison; blanca herrera; David A Dyment; Sarah M Orton; M T Bihoreau; A Degenhardt; Maura Pugliatti; A Dessa Sadovnick; Stefano Sotgiu; George C Ebers
No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis.
Journal of neuroimmunology 2007;186(1-2):156-60.
2007: Sreeram V Ramagopalan; David A Dyment; blanca herrera; Maria Criscuoli; Irene M L Yee; A Dessa Sadovnick; George C Ebers
Clustering of autoimmune disease in families at high risk for multiple sclerosis?
Lancet neurology 2007;6(3):206-7; author reply 207.
2007: Cristen J Willer; David A Dyment; Stacey Cherny; Sreeram V Ramagopalan; blanca herrera; Katie M E Morrison; A Dessa Sadovnick; Neil J Risch; George C Ebers
A genome-wide scan in forty large pedigrees with multiple sclerosis.
Journal of human genetics 2007;52(12):955-62.
2006: blanca herrera; zameel cader; David A Dyment; Jordana Tzenova Bell; Sreeram V Ramagopalan; Matthew R Lincoln; Sarah M Orton; Michael J Chao; A Dessa Sadovnick; George C Ebers
Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.
Genes and immunity 2006;7(5):366-71.
2006: David A Dyment; Irene M L Yee; George C Ebers; A Dessa Sadovnick
Multiple sclerosis in stepsiblings: recurrence risk and ascertainment.
Journal of neurology, neurosurgery, and psychiatry 2006;77(2):258-9.
2005: Matthew R Lincoln; Alexandre Montpetit; zameel cader; Janna Saarela; David A Dyment; Milvi Tiislar; Vincent Ferretti; Pentti J Tienari; A Dessa Sadovnick; Leena Peltonen; George C Ebers; Thomas J Hudson
A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.
Nature genetics 2005;37(10):1108-12.
2005: David A Dyment; blanca herrera; zameel cader; Cristen J Willer; Matthew R Lincoln; A Dessa Sadovnick; Neil Risch; George C Ebers
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.
Human molecular genetics 2005;14(14):2019-26.
2005: zameel cader; JL Steckley; David A Dyment; R S McLachlan; George C Ebers
A genome-wide screen and linkage mapping for a large pedigree with episodic ataxia.
Neurology 2005;65(1):156-8.
2005: Cristen J Willer; David A Dyment; A Dessa Sadovnick; George C Ebers
Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis.
Tissue antigens 2005;66(1):44-7.
2005: Cristen J Willer; David A Dyment; A Dessa Sadovnick; Peter M Rothwell; T Jock Murray; George C Ebers
Timing of birth and risk of multiple sclerosis: population based study.
BMJ (Clinical research ed.) 2005;330(7483):120.
2004: David A Dyment; JL Steckley; K Morrison; Cristen J Willer; zameel cader; Gabriele C DeLuca; A Dessa Sadovnick; Neil Risch; George C Ebers
TCR beta polymorphisms and multiple sclerosis.
Genes and immunity 2004;5(5):337-42.
2004: George C Ebers; A Dessa Sadovnick; David A Dyment; Irene M L Yee; Cristen J Willer; Neil Risch
Parent-of-origin effect in multiple sclerosis: observations in half-siblings.
Lancet 2004;363(9423):1773-4.
2004: David A Dyment; A Dessa Sadovnick; Cristen J Willer; Holly Armstrong; zameel cader; Steven Wiltshire; Bernadette Kalman; Neil Risch; George C Ebers
An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group.
Human molecular genetics 2004;13(10):1005-15.
2004: David A Dyment; George C Ebers; A Dessa Sadovnick
Genetics of multiple sclerosis.
Lancet neurology 2004;3(2):104-10.
2003: Cristen J Willer; David A Dyment; Neil J Risch; A Dessa Sadovnick; George C Ebers
Twin concordance and sibling recurrence rates in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12877-82.
2003: zameel cader; Sandra Noble-Topham; David A Dyment; Stacey Cherny; John D Brown; G P A Rice; George C Ebers
Significant linkage to migraine with aura on chromosome 11q24.
Human molecular genetics 2003;12(19):2511-7.
2003: Sandra Noble-Topham; zameel cader; David A Dyment; G P A Rice; John D Brown; George C Ebers
Genetic loading in familial migraine with aura.
Journal of neurology, neurosurgery, and psychiatry 2003;74(8):1128-30.
2002: David A Dyment; George C Ebers
An array of sunshine in multiple sclerosis.
The New England journal of medicine 2002;347(18):1445-7.
2002: Sandra Noble-Topham; David A Dyment; zameel cader; R Ganapathy; John D Brown; G P A Rice; George C Ebers
Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13.
Neurology 2002;59(7):1099-101.
2002: David A Dyment; zameel cader; Cristen J Willer; Neil Risch; A Dessa Sadovnick; George C Ebers
A multigenerational family with multiple sclerosis.
Brain : a journal of neurology 2002;125(Pt 7):1474-82.
2002: David A Dyment; JL Steckley; Cristen J Willer; H Armstrong; A Dessa Sadovnick; Neil Risch; George C Ebers
No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study.
Journal of neuroimmunology 2002;123(1-2):193-8.
2001: Arturs Ligers; David A Dyment; Cristen J Willer; A Dessa Sadovnick; George C Ebers; N Risch; Jan Hillert
Evidence of linkage with HLA-DR in DRB1*15-negative families with multiple sclerosis.
American journal of human genetics 2001;69(4):900-3.
2000: JL Steckley; David A Dyment; A Dessa Sadovnick; Neil Risch; C Hayes; George C Ebers
Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group.
Neurology 2000;54(3):729-32.
1998: George C Ebers; David A Dyment
Genetics of multiple sclerosis.
Seminars in neurology 1998;18(3):295-9.
1997: A D Sadovnick; David A Dyment; G C Ebers
Genetic epidemiology of multiple sclerosis.
Epidemiologic reviews 1997;19(1):99-106.
1997: David A Dyment; A Dessa Sadovnick; George C Ebers; A D Sadnovich
Genetics of multiple sclerosis.
Human molecular genetics 1997;6(10):1693-8.
1996: A Dessa Sadovnick; George C Ebers; David A Dyment; N J Risch
Evidence for genetic basis of multiple sclerosis. The Canadian Collaborative Study Group.
Lancet 1996;347(9017):1728-30.