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Steven Ealick

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TOP 3
Katherine A Hicks; Seán E O'Leary; Tadhg P Begley; Steven E Ealick
Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae.
Siyu Huang; Nilkamal Mahanta; Tadhg P Begley; Steven E Ealick
Pseudouridine monophosphate glycosidase: a new glycosidase mechanism.
Tanja Knaus; Julia Koop; Steven E Ealick; Elisabeth Eger; Cynthia L Kinsland; Steve Stipsits; Peter Macheroux
Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron.

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All Publications

2013: Katherine A Hicks; Seán E O'Leary; Tadhg P Begley; Steven E Ealick
Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae.
Biochemistry 2013;52(3):477-87.
2012: Siyu Huang; Nilkamal Mahanta; Tadhg P Begley; Steven E Ealick
Pseudouridine monophosphate glycosidase: a new glycosidase mechanism.
Biochemistry 2012;51(45):9245-55.
2012: Tanja Knaus; Julia Koop; Steven E Ealick; Elisabeth Eger; Cynthia L Kinsland; Steve Stipsits; Peter Macheroux
Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron.
The Journal of biological chemistry 2012;287(33):27490-8.
2012: Rung-Yi Lai; Benjamin Philmus; Kanagalaghatta Rajashankar; Jennie Mansell Sanders; Yang Zhang; Steven E Ealick; Michael K Fenwick; Amrita Hazra; Siyu Huang; Cynthia Kinsland; Tadhg P Begley
Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate.
Journal of the American Chemical Society 2012;134(22):9157-9.
2012: Tadhg P Begley; Steven E Ealick; Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochemical Society transactions 2012;40(3):555-60.
2012: Benjamin Philmus; Howard J Williams; Sameh Abdelwahed; Steven E Ealick; Michael K Fenwick; Tadhg P Begley
Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.
Journal of the American Chemical Society 2012;134(11):5326-30.
2012: Yang Zhang; Peter H Zwart; Steven E Ealick
A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 3):249-52.
2012: Paola Dessanti; Francesco Sgarrella; Maria Grazia Tozzi; Yang Zhang; Simone Allegrini; Steven E Ealick
Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 3):239-48.
2011: Jolita Sečkutė; John A Secrist; H Jeanette Thomas; Diane E McCloskey; Anthony E Pegg; Steven E Ealick
Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.
Protein science : a publication of the Protein Society 2011;20(11):1836-44.
2011: Tathagata Mukherjee; Ivo Tews; Steven E Ealick; Jeremiah Hanes; Tadhg P Begley
Pyridoxal phosphate: biosynthesis and catabolism.
Biochimica et biophysica acta 2011;1814(11):1585-96.
2011: abhishek chatterjee; Pieter dorrestein; Steven E Ealick; Pei-Jing Pai; David H Russell; N Dinuka Abeydeera; Shridhar Bale; Tadhg P Begley
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
Nature 2011;478(7370):542-6.
2011: Timothy H Tran; Kalyanaraman Krishnamoorthy; Tadhg P Begley; Steven E Ealick
A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 10):831-8.
2011: Jarrod B French; Tadhg P Begley; Steven E Ealick
Structure of trifunctional THI20 from yeast.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 9):784-91.
2011: Timothy H Tran; Paula W Allan; S Christoffersen; William B Parker; Jure Piskur; I Serra; M Terreni; Steven E Ealick
The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases.
Biochemistry 2011;50(30):6549-58.
2011: Jarrod B French; Steven E Ealick
Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae.
Acta crystallographica. Section D, Biological crystallography 2011;67(Pt 8):671-7.
2011: Peter Macheroux; Barbara Kappes; Steven E Ealick
Flavogenomics--a genomic and structural view of flavin-dependent proteins.
The FEBS journal 2011;278(15):2625-34.
2011: Jarrod B French; David B Neau; Steven E Ealick
Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase.
Journal of molecular biology 2011;410(3):447-60.
2011: Amrita B Hazra; Rung-Yi Lai; Yang Zhang; abhishek chatterjee; Steven E Ealick; Ying Han; Tadhg P Begley
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase.
Journal of the American Chemical Society 2011;133(24):9311-9.
2011: Jarrod B French; Phillip A Yates; D Radika Soysa; Jan M Boitz; Nicola S Carter; Bailey Chang; Buddy Ullman; Steven E Ealick
The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization.
The Journal of biological chemistry 2011;286(23):20930-41.
2011: Jeremiah W Hanes; Debashree Chatterjee; Erika V Soriano; Steven E Ealick; Tadhg P Begley
Construction of a thiamin sensor from the periplasmic thiamin binding protein.
Chemical communications (Cambridge, England) 2011;47(8):2273-5.
2011: Michael K Fenwick; Benjamin Philmus; Tadhg P Begley; Steven E Ealick
Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad.
Biochemistry 2011;50(6):1091-100.
2011: Xuling Zhu; Boris Dzikovski; Xiaoyang Su; Andrew T Torelli; Yang Zhang; Steven E Ealick; Jack H Freed; Hening Lin
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis.
Molecular bioSystems 2011;7(1):74-81.
2010: Debamita Paul; abhishek chatterjee; Tadhg P Begley; Steven E Ealick
Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes.
Biochemistry 2010;49(45):9922-34.
2010: Jarrod B French; Steven E Ealick
Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
The Journal of biological chemistry 2010;285(46):35446-54.
2010: Shridhar Bale; Kanagalaghatta R Rajashankar; Kay Perry; Tadhg P Begley; Steven E Ealick
HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues.
Biochemistry 2010;49(41):8929-36.
2010: Jarrod B French; Yana Cen; Anthony A Sauve; Steven E Ealick
High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry 2010;49(40):8803-12.
2010: John B Woodward; N Dinuka Abeydeera; Debamita Paul; Kimberly Phillips; Maria Rapala-Kozik; Michael Freeling; Tadhg P Begley; Steven E Ealick; Paula McSteen; Michael J Scanlon
A maize thiamine auxotroph is defective in shoot meristem maintenance.
The Plant cell 2010;22(10):3305-17.
2010: Jarrod B French; Steven E Ealick
Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway.
Biochemistry 2010;49(29):5975-7.
2010: Yang Zhang; Xuling Zhu; Andrew T Torelli; Michael Lee; Boris Dzikovski; Rachel M Koralewski; Eileen Wang; Jack Freed; Carsten Krebs; Steven E Ealick; Hening Lin
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Nature 2010;465(7300):891-6.
2010: Debamita Paul; Seán E O'Leary; Kanagalaghatta R Rajashankar; Weiming Bu; Angela V Toms; Ethan C Settembre; Jennie M Sanders; Tadhg P Begley; Steven E Ealick
Glycal formation in crystals of uridine phosphorylase.
Biochemistry 2010;49(16):3499-509.
2010: Kathryn M McCulloch; Tathagata Mukherjee; Tadhg P Begley; Steven E Ealick
Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase.
Biochemistry 2010;49(6):1226-35.
2010: William J Cook; Nicholas Galakatos; William C Boyar; Richard L Walter; Steven E Ealick
Structure of human desArg-C5a.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):190-7.
2010: Shridhar Bale; Kavita Baba; Diane E McCloskey; Anthony E Pegg; Steven E Ealick
Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):181-9.
2010: You-Na Kang; Yang Zhang; Paula W Allan; William B Parker; Jing-Wen Ting; Chi-Yao Chang; Steven E Ealick
Structure of grouper iridovirus purine nucleoside phosphorylase.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):155-62.
2010: Shridhar Bale; Steven E Ealick
Structural biology of S-adenosylmethionine decarboxylase.
Amino acids 2010;38(2):451-60.
2009: Shridhar Bale; Wesley Brooks; Jeremiah Hanes; Arnold M Mahesan; Wayne C Guida; Steven E Ealick
Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Biochemistry 2009;48(27):6423-30.
2009: Kathryn M McCulloch; Tathagata Mukherjee; Tadhg P Begley; Steven E Ealick
Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications.
Biochemistry 2009;48(19):4139-49.
2009: Seán E O'Leary; Katherine A Hicks; Steven E Ealick; Tadhg P Begley
Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase.
Biochemistry 2009;48(14):3033-5.
2009: Diane E McCloskey; Shridhar Bale; John A Secrist; Anita Tiwari; Thomas H Moss; Jacob Valiyaveettil; Wesley H Brooks; Wayne C Guida; Anthony E Pegg; Steven E Ealick
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Journal of medicinal chemistry 2009;52(5):1388-407.
2009: Christopher T Jurgenson; Tadhg P Begley; Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annual review of biochemistry 2009;78():569-603.
2008: abhishek chatterjee; Yue Li; Yang Zhang; Tyler L Grove; Michael Lee; Carsten Krebs; Squire J Booker; Tadhg P Begley; Steven E Ealick
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Nature chemical biology 2008;4(12):758-65.
2008: Seán E O'Leary; Christopher T Jurgenson; Steven E Ealick; Tadhg P Begley
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
Biochemistry 2008;47(44):11606-15.
2008: Yeli Zhang; Mariya Morar; Steven E Ealick
Structural biology of the purine biosynthetic pathway.
Cellular and molecular life sciences : CMLS 2008;65(23):3699-724.
2008: Christopher T Jurgenson; Kristin E Burns; Tadhg P Begley; Steven E Ealick
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
Biochemistry 2008;47(39):10354-64.
2008: abhishek chatterjee; Frank Schroeder; Christopher T Jurgenson; Steven E Ealick; Tadhg P Begley
Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate.
Journal of the American Chemical Society 2008;130(34):11394-8.
2008: Mariya Morar; Aaron A Hoskins; JoAnne Stubbe; Steven E Ealick
Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation.
Biochemistry 2008;47(30):7816-30.
2008: Erika V Soriano; Diane E McCloskey; Cynthia Kinsland; Anthony E Pegg; Steven E Ealick
Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 4):377-82.
2008: Tadhg P Begley; abhishek chatterjee; Jeremiah Hanes; Amrita Hazra; Steven E Ealick
Cofactor biosynthesis--still yielding fascinating new biological chemistry.
Current opinion in chemical biology 2008;12(2):118-25.
2008: Kathryn M McCulloch; Cynthia Kinsland; Tadhg P Begley; Steven E Ealick
Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry 2008;47(12):3810-21.
2008: Erika V Soriano; Kanagalaghatta R Rajashankar; Jeremiah Hanes; Shridhar Bale; Tadhg P Begley; Steven E Ealick
Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor.
Biochemistry 2008;47(5):1346-57.
2008: Amy L Jenkins; Yang Zhang; Steven E Ealick; Tadhg P Begley
Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis.
Bioorganic chemistry 2008;36(1):29-32.
2008: Yang Zhang; Robert H White; Steven E Ealick
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry 2008;47(1):205-17.
2008: Ingrid Müller; Julia Knöckel; Matthew R Groves; Rositsa Jordanova; Steven E Ealick; Rolf D Walter; Carsten Wrenger
The assembly of the plasmodial PLP synthase complex follows a defined course.
PloS one 2008;3(3):e1815.
2007: Erika V Soriano; Valerie C Clark; Steven E Ealick
Structures of human deoxycytidine kinase product complexes.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 12):1201-7.
2007: Tathagata Mukherjee; Kathryn M McCulloch; Steven E Ealick; Tadhg P Begley
Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099.
Biochemistry 2007;46(47):13606-15.
2007: Lovy Pradeep; Igor Kurinov; Steven E Ealick; Harold A Scheraga
Implementation of a k/k(0) method to identify long-range structure in transition states during conformational folding/unfolding of proteins.
Structure (London, England : 1993) 2007;15(10):1178-89.
2007: Mariya Morar; Robert H White; Steven E Ealick
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry 2007;46(37):10562-71.
2007: Wesley H Brooks; Diane E McCloskey; Kenyon G Daniel; Steven E Ealick; John A Secrist; William R Waud; Anthony E Pegg; Wayne C Guida
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.
Journal of chemical information and modeling 2007;47(5):1897-905.
2007: You-Na Kang; Anh Tran; Robert H White; Steven E Ealick
A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase.
Biochemistry 2007;46(17):5050-62.
2007: Jeremiah Hanes; Steven E Ealick; Tadhg P Begley
Thiamin phosphate synthase: the rate of pyrimidine carbocation formation.
Journal of the American Chemical Society 2007;129(16):4860-1.
2007: Steven E Ealick; Tadhg P Begley
Biochemistry: molecular cannibalism.
Nature 2007;446(7134):387-8.
2007: abhishek chatterjee; Christopher T Jurgenson; Frank Schroeder; Steven E Ealick; Tadhg P Begley
Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate.
Journal of the American Chemical Society 2007;129(10):2914-22.
2007: Aaron A Hoskins; Mariya Morar; T Joseph Kappock; Irimpan I Mathews; Judith B Zaugg; Timothy E Barder; Paul Peng; Akimitsu Okamoto; Steven E Ealick; JoAnne Stubbe
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis.
Biochemistry 2007;46(10):2842-55.
2007: Yan Zhang; Mahmoud el Kouni; Steven E Ealick
Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 2):126-34.
2007: Yang Zhang; Seong Woo A. Kang; Tathagata Mukherjee; Shridhar Bale; Brian R Crane; Tadhg P Begley; Steven E Ealick
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
Biochemistry 2007;46(1):145-55.
2006: Mariya Morar; Ruchi Anand; Aaron A Hoskins; JoAnne Stubbe; Steven E Ealick
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily.
Biochemistry 2006;45(50):14880-95.
2006: Fairuz Zein; Yan Zhang; You-Na Kang; Kristin Burns; Tadhg P Begley; Steven E Ealick
Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima.
Biochemistry 2006;45(49):14609-20.
2006: Christopher T Jurgenson; abhishek chatterjee; Tadhg P Begley; Steven E Ealick
Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae.
Biochemistry 2006;45(37):11061-70.
2006: abhishek chatterjee; Christopher T Jurgenson; Frank Schroeder; Steven E Ealick; Tadhg P Begley
Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis.
Journal of the American Chemical Society 2006;128(22):7158-9.
2006: Yan Zhang; Marina Porcelli; Giovanna Cacciapuoti; Steven E Ealick
The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds.
Journal of molecular biology 2006;357(1):252-62.
2006: Guoqiang Xu; Mahesh Narayan; Igor Kurinov; Daniel R Ripoll; Ervin Welker; Mey Khalili; Steven E Ealick; Harold A Scheraga
A localized specific interaction alters the unfolding pathways of structural homologues.
Journal of the American Chemical Society 2006;128(4):1204-13.
2006: Yan Zhang; Mahmoud el Kouni; Steven E Ealick
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):140-5.
2006: Yan Zhang; John A Secrist; Steven E Ealick
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):133-9.
2006: Christopher Lehmann; Tadhg P Begley; Steven E Ealick
Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis.
Biochemistry 2006;45(1):11-9.
2005: Angela V Toms; Weiru Wang; Yingbo Li; Bruce Ganem; Steven E Ealick
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1449-58.
2005: Weiming Bu; Ethan C Settembre; Mahmoud el Kouni; Steven E Ealick
Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 7):863-72.
2005: Yang Zang; Wen-Hu Wang; Shaw-Wen Wu; Steven E Ealick; Ching C Wang
Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.
The Journal of biological chemistry 2005;280(23):22318-25.
2005: Yang Zhang; Keri L Colabroy; Tadhg P Begley; Steven E Ealick
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis.
Biochemistry 2005;44(21):7632-43.
2005: Keri L Colabroy; Huili Zhai; Tingfeng Li; Ying Ge; Yang Zhang; Aimin Liu; Steven E Ealick; Fred W McLafferty; Tadhg P Begley
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate.
Biochemistry 2005;44(21):7623-31.
2005: Mariya V Dontsova; Azat G Gabdoulkhakov; Olga K Molchan; Alexandr A Lashkov; Maria B Garber; Alexander S Mironov; Nadezhda E Zhukhlistova; Ekaterina Yu Morgunova; Wolfgang Voelter; Christian Betzel; Yang Zhang; Steven E Ealick; Al'bert M Mikhailov
Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 4):337-40.
2005: Angela V Toms; Amy L Haas; Joo-Heon Park; Tadhg P Begley; Steven E Ealick
Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.
Biochemistry 2005;44(7):2319-29.
2005: Yang Zhang; William B Parker; Eric J Sorscher; Steven E Ealick
PNP anticancer gene therapy.
Current topics in medicinal chemistry 2005;5(13):1259-74.
2005: William B Parker; Paula W Allan; Steven E Ealick; Eric J Sorscher; Abdalla E A Hassan; A V Silamkoti; Anita T Fowler; William R Waud; John A Secrist
Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):387-92.
2004: Yan Zhang; Michael Dougherty; Diana Marie Downs; Steven E Ealick
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily.
Structure (London, England : 1993) 2004;12(10):1809-21.
2004: Tadhg P Begley; Steven E Ealick
Enzymatic reactions involving novel mechanisms of carbanion stabilization.
Current opinion in chemical biology 2004;8(5):508-15.
2004: Ethan C Settembre; Johnathan R Chittuluru; Christopher P Mill; T Joseph Kappock; Steven E Ealick
Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE).
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1753-60.
2004: Ethan C Settembre; Pieter dorrestein; Huili Zhai; abhishek chatterjee; Fred W McLafferty; Tadhg P Begley; Steven E Ealick
Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.
Biochemistry 2004;43(37):11647-57.
2004: Jun Wang; Steven E Ealick
Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1579-85.
2004: Bogachan Sahin; Janice W Kansy; Angus Nairn; Jozef Spychala; Steven E Ealick; Allen Fienberg; Robert W Greene; James A Bibb
Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation.
European journal of biochemistry / FEBS 2004;271(17):3547-55.
2004: Ruchi Anand; Aaron A Hoskins; Eric M Bennett; Michael D Sintchak; JoAnne Stubbe; Steven E Ealick
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex.
Biochemistry 2004;43(32):10343-52.
2004: Ruchi Anand; Aaron A Hoskins; JoAnne Stubbe; Steven E Ealick
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography.
Biochemistry 2004;43(32):10328-42.
2004: Aaron A Hoskins; Ruchi Anand; Steven E Ealick; JoAnne Stubbe
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation.
Biochemistry 2004;43(32):10314-27.
2004: Angela V Toms; Cynthia Kinsland; Diane E McCloskey; Anthony E Pegg; Steven E Ealick
Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.
The Journal of biological chemistry 2004;279(32):33837-46.
2004: Yang Zhang; Sarah E Cottet; Steven E Ealick
Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases.
Structure (London, England : 1993) 2004;12(8):1383-94.
2004: Jeffrey E Lee; Ethan C Settembre; Ken Cornell; Michael K Riscoe; Janice R Sufrin; Steven E Ealick; P Lynne Howell
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
Biochemistry 2004;43(18):5159-69.
2004: Mariya V Dontsova; Yulia A Savochkina; Azat G Gabdoulkhakov; Sergey N Baidakov; Andrey V Lyashenko; Maria Zolotukhina; Liubov Errais Lopes; Maria B Garber; Ekaterina Yu Morgunova; Stanislav Nikonov; Alexander S Mironov; Steven E Ealick; Al'bert M Mikhailov
Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):709-11.
2004: Ruchi Anand; Pierre Alexandre Kaminski; Steven E Ealick
Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution.
Biochemistry 2004;43(9):2384-93.
2004: Jacob A Bauer; Eric M Bennett; Tadhg P Begley; Steven E Ealick
Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis.
The Journal of biological chemistry 2004;279(4):2704-11.
2003: Eric M Bennett; Ruchi Anand; Paula W Allan; Abdalla E A Hassan; Jeong S Hong; Dana Levasseur; David T McPherson; William B Parker; John A Secrist; Eric J Sorscher; Tim M Townes; William R Waud; Steven E Ealick
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chemistry & biology 2003;10(12):1173-81.
2003: Ethan C Settembre; Tadhg P Begley; Steven E Ealick
Structural biology of enzymes of the thiamin biosynthesis pathway.
Current opinion in structural biology 2003;13(6):739-47.
2003: Eric M Bennett; Chenglong Li; Paula W Allan; William B Parker; Steven E Ealick
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
The Journal of biological chemistry 2003;278(47):47110-8.
2003: Narayanan Manoj; Steven E Ealick
Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 10):1762-6.
2003: Narayanan Manoj; Erick Strauss; Tadhg P Begley; Steven E Ealick
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
Structure (London, England : 1993) 2003;11(8):927-36.
2003: Qun Shen; Jun Wang; Steven E Ealick
Anomalous difference signal in protein crystals.
Acta crystallographica. Section A, Foundations of crystallography 2003;59(Pt 4):371-3.
2003: Ethan C Settembre; Pieter dorrestein; Joo-Heon Park; Amy M Augustine; Tadhg P Begley; Steven E Ealick
Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.
Biochemistry 2003;42(10):2971-81.
2003: William D Tolbert; Yang Zhang; Sarah E Cottet; Eric M Bennett; Jennifer L Ekstrom; Anthony E Pegg; Steven E Ealick
Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant.
Biochemistry 2003;42(8):2386-95.
2003: William D Tolbert; David E Graham; Robert H White; Steven E Ealick
Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms.
Structure (London, England : 1993) 2003;11(3):285-94.
2002: Eric M Bennett; Jennifer L Ekstrom; Anthony E Pegg; Steven E Ealick
Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation.
Biochemistry 2002;41(49):14509-17.
2002: Ruchi Anand; Pieter dorrestein; Cynthia Kinsland; Tadhg P Begley; Steven E Ealick
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.
Biochemistry 2002;41(24):7659-69.
2002: William J Cook; Alan Zell; Dean D Watt; Steven E Ealick
Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing.
Protein science : a publication of the Protein Society 2002;11(3):479-86.
2002: Gong Cheng; Eric M Bennett; Tadhg P Begley; Steven E Ealick
Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure (London, England : 1993) 2002;10(2):225-35.
2002: Matthew J Pugmire; Steven E Ealick
Structural analyses reveal two distinct families of nucleoside phosphorylases.
The Biochemical journal 2002;361(Pt 1):1-25.
2001: TC Appleby; Irimpan I Mathews; Marina Porcelli; Giovanna Cacciapuoti; Steven E Ealick
Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
The Journal of biological chemistry 2001;276(42):39232-42.
2001: D H Peapus; HJ Chiu; N Campobasso; Jason J Reddick; Tadhg P Begley; Steven E Ealick
Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry 2001;40(34):10103-14.
2001: Jennifer L Ekstrom; William D Tolbert; H Xiong; Anthony E Pegg; Steven E Ealick
Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.
Biochemistry 2001;40(32):9495-504.
2001: William D Tolbert; Jennifer L Ekstrom; Irimpan I Mathews; John A Secrist; Preeti Kapoor; Anthony E Pegg; Steven E Ealick
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry 2001;40(32):9484-94.
2001: Y Ni; Peter McPhie; Ashley M Deacon; Steven E Ealick; William G Coleman
Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase.
The Journal of biological chemistry 2001;276(29):27329-34.
2000: Tadhg P Begley; TC Appleby; Steven E Ealick
The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.
Current opinion in structural biology 2000;10(6):711-8.
2000: T Joseph Kappock; Steven E Ealick; JoAnne Stubbe
Modular evolution of the purine biosynthetic pathway.
Current opinion in chemical biology 2000;4(5):567-72.
2000: Steven E Ealick
Advances in multiple wavelength anomalous diffraction crystallography.
Current opinion in chemical biology 2000;4(5):495-9.
2000: Daniel J Thiel; M H le Du; R L Walter; Allan D'Arcy; C Chène; M Fountoulakis; G Garotta; Fritz K Winkler; Steven E Ealick
Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.
Structure (London, England : 1993) 2000;8(9):927-36.
2000: N Campobasso; Irimpan I Mathews; Tadhg P Begley; Steven E Ealick
Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
Biochemistry 2000;39(27):7868-77.
2000: Ashley M Deacon; Y S Ni; William G Coleman; Steven E Ealick
The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.
Structure (London, England : 1993) 2000;8(5):453-62.
2000: TC Appleby; Cynthia Kinsland; Tadhg P Begley; Steven E Ealick
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2005-10.
1999: Irimpan I Mathews; T Joseph Kappock; JoAnne Stubbe; Steven E Ealick
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure (London, England : 1993) 1999;7(11):1395-406.
1999: C Li; T J Kappock; J Stubbe; T M Weaver; Steven E Ealick
X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.
Structure (London, England : 1993) 1999;7(9):1155-66.
1999: E J Mueller; S Oh; E Kavalerchik; T Joseph Kappock; E Meyer; C Li; Steven E Ealick; JoAnne Stubbe
Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis.
Biochemistry 1999;38(31):9831-9.
1999: Ashley M Deacon; Steven E Ealick
Selenium-based MAD phasing: setting the sites on larger structures.
Structure (London, England : 1993) 1999;7(7):R161-6.
1999: TC Appleby; M D Erion; Steven E Ealick
The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis.
Structure (London, England : 1993) 1999;7(6):629-41.
1999: HJ Chiu; Jason J Reddick; Tadhg P Begley; Steven E Ealick
Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution.
Biochemistry 1999;38(20):6460-70.
1999: Jennifer L Ekstrom; Irimpan I Mathews; Bruce Stanley; Anthony E Pegg; Steven E Ealick
The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold.
Structure (London, England : 1993) 1999;7(5):583-95.
1999: John A Secrist; William B Parker; Paula W Allan; LL Bennett; William R Waud; J W Truss; Anita T Fowler; John A Montgomery; Steven E Ealick; A H Wells; G Yancey Gillespie; Vijayakrishna K Gadi; Eric J Sorscher
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.
Nucleosides & nucleotides 1999;18(4-5):745-57.
1999: Tadhg P Begley; Diana Marie Downs; Steven E Ealick; Fred W McLafferty; A P Van Loon; S Taylor; N Campobasso; HJ Chiu; Cynthia Kinsland; Jason J Reddick; J Xi
Thiamin biosynthesis in prokaryotes.
Archives of microbiology 1999;171(5):293-300.
1999: L Ding; Y Zhang; Ashley M Deacon; Steven E Ealick; Y Ni; P Sun; William G Coleman
Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerase from Escherichia coli K-12.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):685-8.
1999: T M Weaver; W Wang; Steven E Ealick
Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetase.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):518-21.
1999: M Zhou; Matthew J Pugmire; B Q Vuong; Steven E Ealick
Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):287-90.
1998: Matthew J Pugmire; Steven E Ealick
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
Structure (London, England : 1993) 1998;6(11):1467-79.
1998: N Campobasso; CA Costello; Cynthia Kinsland; Tadhg P Begley; Steven E Ealick
Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.
Biochemistry 1998;37(45):15981-9.
1998: W Wang; T Joseph Kappock; JoAnne Stubbe; Steven E Ealick
X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli.
Biochemistry 1998;37(45):15647-62.
1998: Irimpan I Mathews; M D Erion; Steven E Ealick
Structure of human adenosine kinase at 1.5 A resolution.
Biochemistry 1998;37(45):15607-20.
1998: John A Secrist; Kamal N Tiwari; AT Shortnacy-Fowler; Lea Messini; J M Riordan; John A Montgomery; S C Meyers; Steven E Ealick
Synthesis and biological activity of certain 4'-thio-D-arabinofuranosylpurine nucleosides.
Journal of medicinal chemistry 1998;41(20):3865-71.
1998: Matthew J Pugmire; William J Cook; A Jasanoff; Mark R Walter; Steven E Ealick
Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
Journal of molecular biology 1998;281(2):285-99.
1998: Ashley M Deacon; C M Weeks; R Miller; Steven E Ealick
The Shake-and-Bake structure determination of triclinic lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9284-9.
1998: Steven E Ealick
Challenges facing structural biology beamlines.
Nature structural biology 1998;5 Suppl():620-3.
1998: C Mao; William J Cook; M Zhou; A A Federov; Steven C Almo; Steven E Ealick
Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues.
Biochemistry 1998;37(20):7135-46.
1998: A M Deacon; TC Appleby; Donald H Bilderback; Steven E Ealick; Ernest Fontes; D J Thiel
Protein crystallography using a multilayer monochromator.
Journal of synchrotron radiation 1998;5(Pt 3):494-6.
1998: N Campobasso; J Begun; CA Costello; Tadhg P Begley; Steven E Ealick
Crystallization and preliminary X-ray analysis of thiaminase I from Bacillus thiaminolyticus: space group change upon freezing of crystals.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):448-50.
1997: C Mao; William J Cook; M Zhou; G W Koszalka; T A Krenitsky; Steven E Ealick
The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology.
Structure (London, England : 1993) 1997;5(10):1373-83.
1997: JD Stoeckler; A F Poirot; R M Smith; R E Parks; Steven E Ealick; K Takabayashi; MD Erion
Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis.
Biochemistry 1997;36(39):11749-56.
1997: MD Erion; JD Stoeckler; Wayne C Guida; R L Walter; Steven E Ealick
Purine nucleoside phosphorylase. 2. Catalytic mechanism.
Biochemistry 1997;36(39):11735-48.
1997: MD Erion; K Takabayashi; H B Smith; Janine Kessi; S Wagner; S Hönger; S L Shames; Steven E Ealick
Purine nucleoside phosphorylase. 1. Structure-function studies.
Biochemistry 1997;36(39):11725-34.
1997: Steven E Ealick
Now we're cooking: new successes for shake-and-bake.
Structure (London, England : 1993) 1997;5(4):469-72.
1997: Sthanam V L Narayana; Charles E Bugg; Steven E Ealick
Refined structure of purine nucleoside phosphorylase at 2.75 A resolution.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 2):131-42.
1996: R L Walter; Steven E Ealick; Alan Friedman; R C Blake; P Proctor; Menachem Shoham
Multiple wavelength anomalous diffraction (MAD) crystal structure of rusticyanin: a highly oxidizing cupredoxin with extreme acid stability.
Journal of molecular biology 1996;263(5):730-51.
1996: S A Short; S R Armstrong; Steven E Ealick; David J T Porter
Active site amino acids that participate in the catalytic mechanism of nucleoside 2'-deoxyribosyltransferase.
The Journal of biological chemistry 1996;271(9):4978-87.
1996: S R Armstrong; William J Cook; S A Short; Steven E Ealick
Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Structure (London, England : 1993) 1996;4(1):97-107.
1996: J Liang; Steven E Ealick; C Nielsen; S L Schreiber; Jon Clardy
Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):207-10.
1995: R L Walter; M C Slaybaugh; Steven E Ealick
An instructional video on the application of cryocrystallographic techniques.
Structure (London, England : 1993) 1995;3(11):1272.
1995: R L Walter; Daniel J Thiel; S L Barna; Mark W Tate; M E Wall; E F Eikenberry; Sol M Gruner; Steven E Ealick
High-resolution macromolecular structure determination using CCD detectors and synchrotron radiation.
Structure (London, England : 1993) 1995;3(8):835-44.
1995: Yarlagadda S Babu; Steven E Ealick; C E Bugg; M D Erion; W C Guida; J A Montgomery; John A Secrist
Structure-based design of inhibitors of purine nucleoside phosphorylase.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):529-35.
1994: W C Guida; R D Elliott; H J Thomas; John A Secrist; Yarlagadda S Babu; C E Bugg; M D Erion; Steven E Ealick; J A Montgomery
Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.
Journal of medicinal chemistry 1994;37(8):1109-14.
1993: M D Erion; S Niwas; J D Rose; Subramaniam Ananthan; M Allen; John A Secrist; Yarlagadda S Babu; C E Bugg; W C Guida; Steven E Ealick
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Journal of medicinal chemistry 1993;36(24):3771-83.
1993: John A Secrist; S Niwas; J D Rose; Yarlagadda S Babu; C E Bugg; M D Erion; W C Guida; Steven E Ealick; J A Montgomery
Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.
Journal of medicinal chemistry 1993;36(13):1847-54.
1993: Steven E Ealick; Yarlagadda S Babu; C E Bugg; M D Erion; W G Guida; J A Montgomery; John A Secrist
Application of X-ray crystallographic methods in the design of purine nucleoside phosphorylase inhibitors.
Annals of the New York Academy of Sciences 1993;685():237-47.
1993: Subramaniam Ananthan; S D Clayton; Steven E Ealick; G Wong; G E Evoniuk; P Skolnick
Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.
Journal of medicinal chemistry 1993;36(4):479-90.
1993: J A Montgomery; S Niwas; J D Rose; John A Secrist; Yarlagadda S Babu; C E Bugg; M D Erion; W C Guida; Steven E Ealick
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.
Journal of medicinal chemistry 1993;36(1):55-69.
1993: John R Helliwell; Steven E Ealick; P Doing; T Irving; M Szebenyi
Towards the measurement of ideal data for macromolecular crystallography using synchrotron sources.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 1):120-8.
1992: Mark R Walter; William J Cook; B G Zhao; R P Cameron; Steven E Ealick; R L Walter; Paul Reichert; TL Nagabhushan; PP Trotta; C E Bugg
Crystal structure of recombinant human interleukin-4.
The Journal of biological chemistry 1992;267(28):20371-6.
1992: Mark R Walter; William J Cook; Steven E Ealick; TL Nagabhushan; PP Trotta; C E Bugg
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.
Journal of molecular biology 1992;224(4):1075-85.
1991: Steven E Ealick; Yarlagadda S Babu; C E Bugg; M D Erion; W C Guida; J A Montgomery; John A Secrist
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11540-4.
1991: Steven E Ealick; William J Cook; S Vijay-Kumar; M Carson; TL Nagabhushan; P P Trotta; C E Bugg
Three-dimensional structure of recombinant human interferon-gamma.
Science (New York, N.Y.) 1991;252(5006):698-702.
1991: William J Cook; Steven E Ealick; Paul Reichert; G S Hammond; Hung Le; TL Nagabhushan; PP Trotta; C E Bugg
Crystallization and preliminary X-ray investigation of recombinant human interleukin 4.
Journal of molecular biology 1991;218(4):675-8.
1991: William J Cook; Steven E Ealick; Yarlagadda S Babu; J A Cox; S Vijay-Kumar
Three-dimensional structure of a sarcoplasmic calcium-binding protein from Nereis diversicolor.
The Journal of biological chemistry 1991;266(1):652-6.
1990: Mark R Walter; William J Cook; L B Cole; S A Short; George W Koszalka; T A Krenitsky; Steven E Ealick
Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.
The Journal of biological chemistry 1990;265(23):14016-22.
1990: William J Cook; S A Short; Steven E Ealick
Crystallization and preliminary X-ray investigation of recombinant Lactobacillus leichmannii nucleoside deoxyribosyltransferase.
The Journal of biological chemistry 1990;265(5):2682-3.
1990: Steven E Ealick; S A Rule; Daniel C. Carter; Trevor J Greenhough; Yarlagadda S Babu; William J Cook; J Habash; John R Helliwell; J D Stoeckler; R E Parks
Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution.
The Journal of biological chemistry 1990;265(3):1812-20.
1990: Paul Reichert; William J Cook; Steven E Ealick; G S Hammond; Hung Le; TL Nagabhushan; PP Trotta; C E Bugg
Crystallization and preliminary x-ray investigation of recombinant human granulocyte-macrophage colony-stimulating factor.
The Journal of biological chemistry 1990;265(1):452-3.
1989: Lawrence J Delucas; C D Smith; H W Smith; S Vijay-Kumar; S E Senadhi; Steven E Ealick; Daniel C. Carter; R S Snyder; P C Weber; Francis Salemme
Protein crystal growth in microgravity.
Science (New York, N.Y.) 1989;246(4930):651-4.
1987: S Vijay-Kumar; S E Senadhi; Steven E Ealick; TL Nagabhushan; PP Trotta; R Kosecki; Paul Reichert; C E Bugg
Crystallization and preliminary X-ray investigation of a recombinant form of human gamma-interferon.
The Journal of biological chemistry 1987;262(10):4804-5.
1987: William J Cook; George W Koszalka; W W Hall; C L Burns; Steven E Ealick
Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli.
The Journal of biological chemistry 1987;262(8):3788-9.
1987: William J Cook; George W Koszalka; W W Hall; Sthanam V L Narayana; Steven E Ealick
Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli.
The Journal of biological chemistry 1987;262(6):2852-3.
1986: J D Stoeckler; Steven E Ealick; C E Bugg; R E Parks
Design of purine nucleoside phosphorylase inhibitors.
Federation proceedings 1986;45(12):2773-8.
1985: William J Cook; Steven E Ealick; T A Krenitsky; J D Stoeckler; John R Helliwell; C E Bugg
Crystallization and preliminary x-ray investigation of purine-nucleoside phosphorylase from Escherichia coli.
The Journal of biological chemistry 1985;260(24):12968-9.
1981: William J Cook; Steven E Ealick; C E Bugg; J D Stoeckler; R E Parks
Crystallization and preliminary X-ray investigation of human erythrocytic purine nucleoside phosphorylase.
The Journal of biological chemistry 1981;256(8):4079-80.