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Steven Ealick

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Procedures

X-Ray Crystallography

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Chemicals & Drugs

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Escherichia coli

Physiology

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Co-Publications
Name
39
Begley, Tadhg
18
Cook, William
14
Secrist, John
10
Stubbe, JoAnne
9
Babu, Yarlagadda
7
Anand, Ruchi
7
Bennett, Eric
7
Kinsland, Cynthia
7
Mathews, Irimpan
7
Zhang, Yang
7
chatterjee, abhishek
6
Settembre, Ethan
6
Nagabhushan, TL
6
Pegg, Anthony
6
Hoskins, Aaron

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Publications

TOP 3
Bale Shridhar; Brooks Wesley; Hanes Jeremiah W; Mahesan Arnold M; Guida Wayne C; Ealick Steven E
Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
McCulloch Kathryn M; Mukherjee Tathagata; Begley Tadhg P; Ealick Steven E
Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications.
O'Leary Seán E; Hicks Katherine A; Ealick Steven E; Begley Tadhg P
Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase.

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All Publications

2009: Bale Shridhar; Brooks Wesley; Hanes Jeremiah W; Mahesan Arnold M; Guida Wayne C; Ealick Steven E
Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
Biochemistry 2009;48(27):6423-30.
2009: McCulloch Kathryn M; Mukherjee Tathagata; Begley Tadhg P; Ealick Steven E
Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications.
Biochemistry 2009;48(19):4139-49.
2009: O'Leary Seán E; Hicks Katherine A; Ealick Steven E; Begley Tadhg P
Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase.
Biochemistry 2009;48(14):3033-5.
2009: Jurgenson Christopher T; Begley Tadhg P; Ealick Steven E
The structural and biochemical foundations of thiamin biosynthesis.
Annual review of biochemistry 2009;78():569-603.
2008: Chatterjee Abhishek; Li Yue; Zhang Yang; Grove Tyler L; Lee Michael; Krebs Carsten; Booker Squire J; Begley Tadhg P; Ealick Steven E
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Nature chemical biology 2008;4(12):758-65.
2008: O'Leary Seán E; Jurgenson Christopher T; Ealick Steven E; Begley Tadhg P
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
Biochemistry 2008;47(44):11606-15.
2008: Zhang Y; Morar M; Ealick S E
Structural biology of the purine biosynthetic pathway.
Cellular and molecular life sciences : CMLS 2008;65(23):3699-724.
2008: Jurgenson Christopher T; Burns Kristin E; Begley Tadhg P; Ealick Steven E
Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis.
Biochemistry 2008;47(39):10354-64.
2008: Chatterjee Abhishek; Schroeder Frank C; Jurgenson Christopher T; Ealick Steven E; Begley Tadhg P
Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate.
Journal of the American Chemical Society 2008;130(34):11394-8.
2008: Morar Mariya; Hoskins Aaron A; Stubbe JoAnne; Ealick Steven E
Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation.
Biochemistry 2008;47(30):7816-30.
2008: Soriano Erika V; McCloskey Diane E; Kinsland Cynthia; Pegg Anthony E; Ealick Steven E
Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 4):377-82.
2008: Begley Tadhg P; Chatterjee Abhishek; Hanes Jeremiah W; Hazra Amrita; Ealick Steven E
Cofactor biosynthesis--still yielding fascinating new biological chemistry.
Current opinion in chemical biology 2008;12(2):118-25.
2008: McCulloch Kathryn M; Kinsland Cynthia; Begley Tadhg P; Ealick Steven E
Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry 2008;47(12):3810-21.
2008: Soriano Erika V; Rajashankar Kanagalaghatta R; Hanes Jeremiah W; Bale Shridhar; Begley Tadhg P; Ealick Steven E
Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor.
Biochemistry 2008;47(5):1346-57.
2008: Jenkins Amy L; Zhang Yang; Ealick Steven E; Begley Tadhg P
Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis.
Bioorganic chemistry 2008;36(1):29-32.
2008: Zhang Yang; White Robert H; Ealick Steven E
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Biochemistry 2008;47(1):205-17.
2008: Müller Ingrid B; Knöckel Julia; Groves Matthew R; Jordanova Rositsa; Ealick Steven E; Walter Rolf D; Wrenger Carsten
The assembly of the plasmodial PLP synthase complex follows a defined course.
PloS one 2008;3(3):e1815.
2007: Soriano Erika V; Clark Valerie C; Ealick Steven E
Structures of human deoxycytidine kinase product complexes.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 12):1201-7.
2007: Mukherjee Tathagata; McCulloch Kathryn M; Ealick Steven E; Begley Tadhg P
Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099.
Biochemistry 2007;46(47):13606-15.
2007: Pradeep Lovy; Kurinov Igor; Ealick Steven E; Scheraga Harold A
Implementation of a k/k(0) method to identify long-range structure in transition states during conformational folding/unfolding of proteins.
Structure (London, England : 1993) 2007;15(10):1178-89.
2007: Morar Mariya; White Robert H; Ealick Steven E
Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry 2007;46(37):10562-71.
2007: Brooks Wesley H; McCloskey Diane E; Daniel Kenyon G; Ealick Steven E; Secrist John A; Waud William R; Pegg Anthony E; Guida Wayne C
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.
Journal of chemical information and modeling 2007;47(5):1897-905.
2007: Kang You-Na; Tran Anh; White Robert H; Ealick Steven E
A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase.
Biochemistry 2007;46(17):5050-62.
2007: Hanes Jeremiah W; Ealick Steven E; Begley Tadhg P
Thiamin phosphate synthase: the rate of pyrimidine carbocation formation.
Journal of the American Chemical Society 2007;129(16):4860-1.
2007: Ealick Steven E; Begley Tadhg P
Biochemistry: molecular cannibalism.
Nature 2007;446(7134):387-8.
2007: Chatterjee Abhishek; Jurgenson Christopher T; Schroeder Frank C; Ealick Steven E; Begley Tadhg P
Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate.
Journal of the American Chemical Society 2007;129(10):2914-22.
2007: Hoskins Aaron A; Morar Mariya; Kappock T Joseph; Mathews Irimpan I; Zaugg Judith B; Barder Timothy E; Peng Paul; Okamoto Akimitsu; Ealick Steven E; Stubbe JoAnne
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis.
Biochemistry 2007;46(10):2842-55.
2007: Zhang Yan; El Kouni Mahmoud H; Ealick Steven E
Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 2):126-34.
2007: Zhang Yang; Kang Seong A; Mukherjee Tathagata; Bale Shridhar; Crane Brian R; Begley Tadhg P; Ealick Steven E
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
Biochemistry 2007;46(1):145-55.
2006: Morar Mariya; Anand Ruchi; Hoskins Aaron A; Stubbe JoAnne; Ealick Steven E
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily.
Biochemistry 2006;45(50):14880-95.
2006: Zein Fairuz; Zhang Yan; Kang You-Na; Burns Kristin; Begley Tadhg P; Ealick Steven E
Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima.
Biochemistry 2006;45(49):14609-20.
2006: Jurgenson Christopher T; Chatterjee Abhishek; Begley Tadhg P; Ealick Steven E
Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae.
Biochemistry 2006;45(37):11061-70.
2006: Chatterjee Abhishek; Jurgenson Christopher T; Schroeder Frank C; Ealick Steven E; Begley Tadhg P
Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis.
Journal of the American Chemical Society 2006;128(22):7158-9.
2006: Zhang Yan; Porcelli Marina; Cacciapuoti Giovanna; Ealick Steven E
The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds.
Journal of molecular biology 2006;357(1):252-62.
2006: Xu Guoqiang; Narayan Mahesh; Kurinov Igor; Ripoll Daniel R; Welker Ervin; Khalili Mey; Ealick Steven E; Scheraga Harold A
A localized specific interaction alters the unfolding pathways of structural homologues.
Journal of the American Chemical Society 2006;128(4):1204-13.
2006: Zhang Yan; El Kouni Mahmoud H; Ealick Steven E
Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):140-5.
2006: Zhang Yan; Secrist John A; Ealick Steven E
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):133-9.
2006: Lehmann Christopher; Begley Tadhg P; Ealick Steven E
Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis.
Biochemistry 2006;45(1):11-9.
2005: Toms Angela V; Wang Weiru; Li Yingbo; Ganem Bruce; Ealick Steven E
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1449-58.
2005: Bu Weiming; Settembre Ethan C; el Kouni Mahmoud H; Ealick Steven E
Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 7):863-72.
2005: Zang Yang; Wang Wen-Hu; Wu Shaw-Wen; Ealick Steven E; Wang Ching C
Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.
The Journal of biological chemistry 2005;280(23):22318-25.
2005: Zhang Yang; Colabroy Keri L; Begley Tadhg P; Ealick Steven E
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis.
Biochemistry 2005;44(21):7632-43.
2005: Colabroy Keri L; Zhai Huili; Li Tingfeng; Ge Ying; Zhang Yang; Liu Aimin; Ealick Steven E; McLafferty Fred W; Begley Tadhg P
The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate.
Biochemistry 2005;44(21):7623-31.
2005: Dontsova Maria V; Gabdoulkhakov Azat G; Molchan Olga K; Lashkov Alexandr A; Garber Maria B; Mironov Alexandr S; Zhukhlistova Nadegda E; Morgunova Ekaterina Yu; Voelter Wolfgang; Betzel Christian; Zhang Yang; Ealick Steven E; Mikhailov Al'bert M
Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 4):337-40.
2005: Toms Angela V; Haas Amy L; Park Joo-Heon; Begley Tadhg P; Ealick Steven E
Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.
Biochemistry 2005;44(7):2319-29.
2005: Zhang Yang; Parker William B; Sorscher Eric J; Ealick Steven E
PNP anticancer gene therapy.
Current topics in medicinal chemistry 2005;5(13):1259-74.
2005: Parker William B; Allan Paula W; Ealick Steve E; Sorscher Eric J; Hassan Abdalla E A; Silamkoti A V; Fowler Anita T; Waud William R; Secrist John A
Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):387-92.
2004: Zhang Yan; Dougherty Michael; Downs Diana M; Ealick Steven E
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily.
Structure (London, England : 1993) 2004;12(10):1809-21.
2004: Begley Tadhg P; Ealick Steven E
Enzymatic reactions involving novel mechanisms of carbanion stabilization.
Current opinion in chemical biology 2004;8(5):508-15.
2004: Settembre Ethan C; Chittuluru Johnathan R; Mill Christopher P; Kappock T Joseph; Ealick Steven E
Acidophilic adaptations in the structure of Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE).
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1753-60.
2004: Settembre Ethan C; Dorrestein Pieter C; Zhai Huili; Chatterjee Abhishek; McLafferty Fred W; Begley Tadhg P; Ealick Steven E
Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.
Biochemistry 2004;43(37):11647-57.
2004: Wang Jun; Ealick Steven E
Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 9):1579-85.
2004: Sahin Bogachan; Kansy Janice W; Nairn Angus C; Spychala Jozef; Ealick Steven E; Fienberg Allen A; Greene Robert W; Bibb James A
Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation.
European journal of biochemistry / FEBS 2004;271(17):3547-55.
2004: Anand Ruchi; Hoskins Aaron A; Bennett Eric M; Sintchak Michael D; Stubbe JoAnne; Ealick Steven E
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex.
Biochemistry 2004;43(32):10343-52.
2004: Anand Ruchi; Hoskins Aaron A; Stubbe JoAnne; Ealick Steven E
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography.
Biochemistry 2004;43(32):10328-42.
2004: Hoskins Aaron A; Anand Ruchi; Ealick Steven E; Stubbe JoAnne
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation.
Biochemistry 2004;43(32):10314-27.
2004: Zhang Yang; Cottet Sarah E; Ealick Steven E
Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases.
Structure (London, England : 1993) 2004;12(8):1383-94.
2004: Toms Angela V; Kinsland Cynthia; McCloskey Diane E; Pegg Anthony E; Ealick Steven E
Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase.
The Journal of biological chemistry 2004;279(32):33837-46.
2004: Lee Jeffrey E; Settembre Ethan C; Cornell Kenneth A; Riscoe Michael K; Sufrin Janice R; Ealick Steven E; Howell P Lynne
Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
Biochemistry 2004;43(18):5159-69.
2004: Dontsova Mariya V; Savochkina Yulia A; Gabdoulkhakov Azat G; Baidakov Sergey N; Lyashenko Andrey V; Zolotukhina Maria; Errais Lopes Liubov; Garber Mariya B; Morgunova Ekaterina Yu; Nikonov Stanislav V; Mironov Alexandr S; Ealick Steven E; Mikhailov Al 'Bert M
Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):709-11.
2004: Anand Ruchi; Kaminski Pierre Alexandre; Ealick Steven E
Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution.
Biochemistry 2004;43(9):2384-93.
2004: Bauer Jacob A; Bennett Eric M; Begley Tadhg P; Ealick Steven E
Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis.
The Journal of biological chemistry 2004;279(4):2704-11.
2003: Bennett Eric M; Anand Ruchi; Allan Paula W; Hassan Abdalla E A; Hong Jeong S; Levasseur Dana N; McPherson David T; Parker William B; Secrist John A; Sorscher Eric J; Townes Tim M; Waud William R; Ealick Steven E
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chemistry & biology 2003;10(12):1173-81.
2003: Settembre Ethan; Begley Tadhg P; Ealick Steven E
Structural biology of enzymes of the thiamin biosynthesis pathway.
Current opinion in structural biology 2003;13(6):739-47.
2003: Bennett Eric M; Li Chenglong; Allan Paula W; Parker William B; Ealick Steven E
Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase.
The Journal of biological chemistry 2003;278(47):47110-8.
2003: Manoj Narayanan; Ealick Steven E
Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 10):1762-6.
2003: Manoj Narayanan; Strauss Erick; Begley Tadhg P; Ealick Steven E
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
Structure (London, England : 1993) 2003;11(8):927-36.
2003: Shen Qun; Wang Jun; Ealick Steven E
Anomalous difference signal in protein crystals.
Acta crystallographica. Section A, Foundations of crystallography 2003;59(Pt 4):371-3.
2003: Settembre Ethan C; Dorrestein Pieter C; Park Joo-Heon; Augustine Amy M; Begley Tadhg P; Ealick Steven E
Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.
Biochemistry 2003;42(10):2971-81.
2003: Tolbert W David; Graham David E; White Robert H; Ealick Steven E
Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms.
Structure (London, England : 1993) 2003;11(3):285-94.
2003: Tolbert William D; Zhang Yang; Cottet Sarah E; Bennett Eric M; Ekstrom Jennifer L; Pegg Anthony E; Ealick Steven E
Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant.
Biochemistry 2003;42(8):2386-95.
2002: Bennett Eric M; Ekstrom Jennifer L; Pegg Anthony E; Ealick Steven E
Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation.
Biochemistry 2002;41(49):14509-17.
2002: Anand Ruchi; Dorrestein Pieter C; Kinsland Cynthia; Begley Tadhg P; Ealick Steven E
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.
Biochemistry 2002;41(24):7659-69.
2002: Cook William J; Zell Alan; Watt Dean D; Ealick Steven E
Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing.
Protein science : a publication of the Protein Society 2002;11(3):479-86.
2002: Cheng Gong; Bennett Eric M; Begley Tadhg P; Ealick Steven E
Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.
Structure (London, England : 1993) 2002;10(2):225-35.
2002: Pugmire Matthew J; Ealick Steven E
Structural analyses reveal two distinct families of nucleoside phosphorylases.
The Biochemical journal 2002;361(Pt 1):1-25.
2001: Appleby T C; Mathews I I; Porcelli M; Cacciapuoti G; Ealick S E
Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.
The Journal of biological chemistry 2001;276(42):39232-42.
2001: Ekstrom J L; Tolbert W D; Xiong H; Pegg A E; Ealick S E
Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.
Biochemistry 2001;40(32):9495-504.
2001: Tolbert W D; Ekstrom J L; Mathews I I; Secrist J A; Kapoor P; Pegg A E; Ealick S E
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
Biochemistry 2001;40(32):9484-94.
2001: Peapus D H; Chiu H J; Campobasso N; Reddick J J; Begley T P; Ealick S E
Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry 2001;40(34):10103-14.
2001: Ni Y; McPhie P; Deacon A; Ealick S; Coleman W G
Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase.
The Journal of biological chemistry 2001;276(29):27329-34.
2000: Begley T P; Appleby T C; Ealick S E
The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.
Current opinion in structural biology 2000;10(6):711-8.
2000: Kappock T J; Ealick S E; Stubbe J
Modular evolution of the purine biosynthetic pathway.
Current opinion in chemical biology 2000;4(5):567-72.
2000: Ealick S E
Advances in multiple wavelength anomalous diffraction crystallography.
Current opinion in chemical biology 2000;4(5):495-9.
2000: Thiel D J; le Du M H; Walter R L; D'Arcy A; Chène C; Fountoulakis M; Garotta G; Winkler F K; Ealick S E
Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.
Structure (London, England : 1993) 2000;8(9):927-36.
2000: Campobasso N; Mathews I I; Begley T P; Ealick S E
Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
Biochemistry 2000;39(27):7868-77.
2000: Deacon A M; Ni Y S; Coleman W G; Ealick S E
The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.
Structure (London, England : 1993) 2000;8(5):453-62.
2000: Appleby T C; Kinsland C; Begley T P; Ealick S E
The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2005-10.
1999: Mathews I I; Kappock T J; Stubbe J; Ealick S E
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure (London, England : 1993) 1999;7(11):1395-406.
1999: Li C; Kappock T J; Stubbe J; Weaver T M; Ealick S E
X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.
Structure (London, England : 1993) 1999;7(9):1155-66.
1999: Mueller E J; Oh S; Kavalerchik E; Kappock T J; Meyer E; Li C; Ealick S E; Stubbe J
Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis.
Biochemistry 1999;38(31):9831-9.
1999: Deacon A M; Ealick S E
Selenium-based MAD phasing: setting the sites on larger structures.
Structure (London, England : 1993) 1999;7(7):R161-6.
1999: Appleby T C; Erion M D; Ealick S E
The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis.
Structure (London, England : 1993) 1999;7(6):629-41.
1999: Ekstrom J L; Mathews I I; Stanley B A; Pegg A E; Ealick S E
The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold.
Structure (London, England : 1993) 1999;7(5):583-95.
1999: Chiu H J; Reddick J J; Begley T P; Ealick S E
Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution.
Biochemistry 1999;38(20):6460-70.
1999: Secrist J A; Parker W B; Allan P W; Bennett L L; Waud W R; Truss J W; Fowler A T; Montgomery J A; Ealick S E; Wells A H; Gillespie G Y; Gadi V K; Sorscher E J
Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.
Nucleosides & nucleotides 1999;18(4-5):745-57.
1999: Begley T P; Downs D M; Ealick S E; McLafferty F W; Van Loon A P; Taylor S; Campobasso N; Chiu H J; Kinsland C; Reddick J J; Xi J
Thiamin biosynthesis in prokaryotes.
Archives of microbiology 1999;171(5):293-300.
1999: Ding L; Zhang Y; Deacon A M; Ealick S E; Ni Y; Sun P; Coleman W G
Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerase from Escherichia coli K-12.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):685-8.
1999: Weaver T M; Wang W; Ealick S E
Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetase.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):518-21.
1999: Zhou M; Pugmire M J; Vuong B Q; Ealick S E
Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):287-90.
1998: Campobasso N; Costello C A; Kinsland C; Begley T P; Ealick S E
Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.
Biochemistry 1998;37(45):15981-9.
1998: Wang W; Kappock T J; Stubbe J; Ealick S E
X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli.
Biochemistry 1998;37(45):15647-62.
1998: Mathews I I; Erion M D; Ealick S E
Structure of human adenosine kinase at 1.5 A resolution.
Biochemistry 1998;37(45):15607-20.
1998: Pugmire M J; Ealick S E
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation.
Structure (London, England : 1993) 1998;6(11):1467-79.
1998: Secrist J A; Tiwari K N; Shortnacy-Fowler A T; Messini L; Riordan J M; Montgomery J A; Meyers S C; Ealick S E
Synthesis and biological activity of certain 4'-thio-D-arabinofuranosylpurine nucleosides.
Journal of medicinal chemistry 1998;41(20):3865-71.
1998: Ealick S E
Challenges facing structural biology beamlines.
Nature structural biology 1998;5 Suppl():620-3.
1998: Pugmire M J; Cook W J; Jasanoff A; Walter M R; Ealick S E
Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
Journal of molecular biology 1998;281(2):285-99.
1998: Deacon A M; Weeks C M; Miller R; Ealick S E
The Shake-and-Bake structure determination of triclinic lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9284-9.
1998: Deacon A M; Appleby T; Bilderback D H; Ealick S E; Fontes E; Thiel D J
Protein crystallography using a multilayer monochromator.
Journal of synchrotron radiation 1998;5(Pt 3):494-6.
1998: Campobasso N; Begun J; Costello C A; Begley T P; Ealick S E
Crystallization and preliminary X-ray analysis of thiaminase I from Bacillus thiaminolyticus: space group change upon freezing of crystals.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):448-50.
1998: Mao C; Cook W J; Zhou M; Federov A A; Almo S C; Ealick S E
Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues.
Biochemistry 1998;37(20):7135-46.
1997: Mao C; Cook W J; Zhou M; Koszalka G W; Krenitsky T A; Ealick S E
The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology.
Structure (London, England : 1993) 1997;5(10):1373-83.
1997: Stoeckler J D; Poirot A F; Smith R M; Parks R E; Ealick S E; Takabayashi K; Erion M D
Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis.
Biochemistry 1997;36(39):11749-56.
1997: Erion M D; Stoeckler J D; Guida W C; Walter R L; Ealick S E
Purine nucleoside phosphorylase. 2. Catalytic mechanism.
Biochemistry 1997;36(39):11735-48.
1997: Erion M D; Takabayashi K; Smith H B; Kessi J; Wagner S; Hönger S; Shames S L; Ealick S E
Purine nucleoside phosphorylase. 1. Structure-function studies.
Biochemistry 1997;36(39):11725-34.
1997: Ealick S E
Now we're cooking: new successes for shake-and-bake.
Structure (London, England : 1993) 1997;5(4):469-72.
1997: Narayana S V; Bugg C E; Ealick S E
Refined structure of purine nucleoside phosphorylase at 2.75 A resolution.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 2):131-42.
1996: Walter R L; Ealick S E; Friedman A M; Blake R C; Proctor P; Shoham M
Multiple wavelength anomalous diffraction (MAD) crystal structure of rusticyanin: a highly oxidizing cupredoxin with extreme acid stability.
Journal of molecular biology 1996;263(5):730-51.
1996: Short S A; Armstrong S R; Ealick S E; Porter D J
Active site amino acids that participate in the catalytic mechanism of nucleoside 2'-deoxyribosyltransferase.
The Journal of biological chemistry 1996;271(9):4978-87.
1996: Liang J; Ealick S; Nielsen C; Schreiber S L; Clardy J
Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):207-10.
1996: Armstrong S R; Cook W J; Short S A; Ealick S E
Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Structure (London, England : 1993) 1996;4(1):97-107.
1995: Walter R L; Slaybaugh M C; Ealick S E
An instructional video on the application of cryocrystallographic techniques.
Structure (London, England : 1993) 1995;3(11):1272.
1995: Walter R L; Thiel D J; Barna S L; Tate M W; Wall M E; Eikenberry E F; Gruner S M; Ealick S E
High-resolution macromolecular structure determination using CCD detectors and synchrotron radiation.
Structure (London, England : 1993) 1995;3(8):835-44.
1995: Babu Y S; Ealick S E; Bugg C E; Erion M D; Guida W C; Montgomery J A; Secrist J A
Structure-based design of inhibitors of purine nucleoside phosphorylase.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):529-35.
1994: Guida W C; Elliott R D; Thomas H J; Secrist J A; Babu Y S; Bugg C E; Erion M D; Ealick S E; Montgomery J A
Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.
Journal of medicinal chemistry 1994;37(8):1109-14.
1993: Erion M D; Niwas S; Rose J D; Ananthan S; Allen M; Secrist J A; Babu Y S; Bugg C E; Guida W C; Ealick S E
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
Journal of medicinal chemistry 1993;36(24):3771-83.
1993: Secrist J A; Niwas S; Rose J D; Babu Y S; Bugg C E; Erion M D; Guida W C; Ealick S E; Montgomery J A
Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.
Journal of medicinal chemistry 1993;36(13):1847-54.
1993: Ealick S E; Babu Y S; Bugg C E; Erion M D; Guida W G; Montgomery J A; Secrist J A
Application of X-ray crystallographic methods in the design of purine nucleoside phosphorylase inhibitors.
Annals of the New York Academy of Sciences 1993;685():237-47.
1993: Ananthan S; Clayton S D; Ealick S E; Wong G; Evoniuk G E; Skolnick P
Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.
Journal of medicinal chemistry 1993;36(4):479-90.
1993: Helliwell J R; Ealick S; Doing P; Irving T; Szebenyi M
Towards the measurement of ideal data for macromolecular crystallography using synchrotron sources.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 1):120-8.
1993: Montgomery J A; Niwas S; Rose J D; Secrist J A; Babu Y S; Bugg C E; Erion M D; Guida W C; Ealick S E
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.
Journal of medicinal chemistry 1993;36(1):55-69.
1992: Walter M R; Cook W J; Zhao B G; Cameron R P; Ealick S E; Walter R L; Reichert P; Nagabhushan T L; Trotta P P; Bugg C E
Crystal structure of recombinant human interleukin-4.
The Journal of biological chemistry 1992;267(28):20371-6.
1992: Walter M R; Cook W J; Ealick S E; Nagabhushan T L; Trotta P P; Bugg C E
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.
Journal of molecular biology 1992;224(4):1075-85.
1991: Ealick S E; Babu Y S; Bugg C E; Erion M D; Guida W C; Montgomery J A; Secrist J A
Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11540-4.
1991: Ealick S E; Cook W J; Vijay-Kumar S; Carson M; Nagabhushan T L; Trotta P P; Bugg C E
Three-dimensional structure of recombinant human interferon-gamma.
Science (New York, N.Y.) 1991;252(5006):698-702.
1991: Cook W J; Ealick S E; Reichert P; Hammond G S; Le H V; Nagabhushan T L; Trotta P P; Bugg C E
Crystallization and preliminary X-ray investigation of recombinant human interleukin 4.
Journal of molecular biology 1991;218(4):675-8.
1991: Cook W J; Ealick S E; Babu Y S; Cox J A; Vijay-Kumar S
Three-dimensional structure of a sarcoplasmic calcium-binding protein from Nereis diversicolor.
The Journal of biological chemistry 1991;266(1):652-6.
1990: Walter M R; Cook W J; Cole L B; Short S A; Koszalka G W; Krenitsky T A; Ealick S E
Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.
The Journal of biological chemistry 1990;265(23):14016-22.
1990: Cook W J; Short S A; Ealick S E
Crystallization and preliminary X-ray investigation of recombinant Lactobacillus leichmannii nucleoside deoxyribosyltransferase.
The Journal of biological chemistry 1990;265(5):2682-3.
1990: Reichert P; Cook W J; Ealick S E; Hammond G S; Le H V; Nagabhushan T L; Trotta P P; Bugg C E
Crystallization and preliminary x-ray investigation of recombinant human granulocyte-macrophage colony-stimulating factor.
The Journal of biological chemistry 1990;265(1):452-3.
1990: Ealick S E; Rule S A; Carter D C; Greenhough T J; Babu Y S; Cook W J; Habash J; Helliwell J R; Stoeckler J D; Parks R E
Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution.
The Journal of biological chemistry 1990;265(3):1812-20.
1989: DeLucas L J; Smith C D; Smith H W; Vijay-Kumar S; Senadhi S E; Ealick S E; Carter D C; Snyder R S; Weber P C; Salemme F R
Protein crystal growth in microgravity.
Science (New York, N.Y.) 1989;246(4930):651-4.
1987: Vijay-Kumar S; Senadhi S E; Ealick S E; Nagabhushan T L; Trotta P P; Kosecki R; Reichert P; Bugg C E
Crystallization and preliminary X-ray investigation of a recombinant form of human gamma-interferon.
The Journal of biological chemistry 1987;262(10):4804-5.
1987: Cook W J; Koszalka G W; Hall W W; Burns C L; Ealick S E
Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli.
The Journal of biological chemistry 1987;262(8):3788-9.
1987: Cook W J; Koszalka G W; Hall W W; Narayana S V; Ealick S E
Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli.
The Journal of biological chemistry 1987;262(6):2852-3.
1986: Stoeckler J D; Ealick S E; Bugg C E; Parks R E
Design of purine nucleoside phosphorylase inhibitors.
Federation proceedings 1986;45(12):2773-8.
1985: Cook W J; Ealick S E; Krenitsky T A; Stoeckler J D; Helliwell J R; Bugg C E
Crystallization and preliminary x-ray investigation of purine-nucleoside phosphorylase from Escherichia coli.
The Journal of biological chemistry 1985;260(24):12968-9.
1981: Cook W J; Ealick S E; Bugg C E; Stoeckler J D; Parks R E
Crystallization and preliminary X-ray investigation of human erythrocytic purine nucleoside phosphorylase.
The Journal of biological chemistry 1981;256(8):4079-80.

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