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William Earnshaw

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Cardinale Stefano; Bergmann Jan H; Kelly David; Nakano Megumi; Valdivia Manuel M; Kimura Hiroshi; Masumoto Hiroshi; Larionov Vladimir; Earnshaw William C
Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier.
Ribeiro Susana A; Gatlin Jesse C; Dong Yimin; Joglekar Ajit; Cameron Lisa; Hudson Damien F; Farr Christine J; McEwen Bruce F; Salmon Edward D; Earnshaw William C; Vagnarelli Paola
Condensin regulates the stiffness of vertebrate centromeres.
Zhou Lihong; Li Jiejin; George Roger; Ruchaud Sandrine; Zhou Hong-Gang; Ladbury John E; Earnshaw William C; Yuan Xuemei
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.

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All Publications

2009: Cardinale Stefano; Bergmann Jan H; Kelly David; Nakano Megumi; Valdivia Manuel M; Kimura Hiroshi; Masumoto Hiroshi; Larionov Vladimir; Earnshaw William C
Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier.
Molecular biology of the cell 2009;20(19):4194-204.
2009: Ribeiro Susana A; Gatlin Jesse C; Dong Yimin; Joglekar Ajit; Cameron Lisa; Hudson Damien F; Farr Christine J; McEwen Bruce F; Salmon Edward D; Earnshaw William C; Vagnarelli Paola
Condensin regulates the stiffness of vertebrate centromeres.
Molecular biology of the cell 2009;20(9):2371-80.
2009: Zhou Lihong; Li Jiejin; George Roger; Ruchaud Sandrine; Zhou Hong-Gang; Ladbury John E; Earnshaw William C; Yuan Xuemei
Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex.
Biochemistry 2009;48(6):1156-61.
2009: Hudson Damien F; Marshall Kathryn M; Earnshaw William C
Condensin: Architect of mitotic chromosomes.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2009;17(2):131-44.
2008: Yue Zuojun; Carvalho Ana; Xu Zhenjie; Yuan Xuemei; Cardinale Stefano; Ribeiro Susana; Lai Fan; Ogawa Hiromi; Gudmundsdottir Elisabet; Gassmann Reto; Morrison Ciaran G; Ruchaud Sandrine; Earnshaw William C
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.
The Journal of cell biology 2008;183(2):279-96.
2008: Tadeu Ana Mafalda Baptista; Ribeiro Susana; Johnston Josiah; Goldberg Ilya; Gerloff Dietlind; Earnshaw William C
CENP-V is required for centromere organization, chromosome alignment and cytokinesis.
The EMBO journal 2008;27(19):2510-22.
2008: Hudson Damien F; Ohta Shinya; Freisinger Tina; Macisaac Fiona; Sennels Lau; Alves Flavia; Lai Fan; Kerr Alastair; Rappsilber Juri; Earnshaw William C
Molecular and genetic analysis of condensin function in vertebrate cells.
Molecular biology of the cell 2008;19(7):3070-9.
2008: Vagnarelli P; Ribeiro S A; Earnshaw W C
Centromeres: old tales and new tools.
FEBS letters 2008;582(14):1950-9.
2008: Nakano Megumi; Cardinale Stefano; Noskov Vladimir N; Gassmann Reto; Vagnarelli Paola; Kandels-Lewis Stefanie; Larionov Vladimir; Earnshaw William C; Masumoto Hiroshi
Inactivation of a human kinetochore by specific targeting of chromatin modifiers.
Developmental cell 2008;14(4):507-22.
2008: Kaufmann Scott H; Lee Sun-Hee; Meng X Wei; Loegering David A; Kottke Timothy J; Henzing Alexander J; Ruchaud Sandrine; Samejima Kumiko; Earnshaw William C
Apoptosis-associated caspase activation assays.
Methods (San Diego, Calif.) 2008;44(3):262-72.
2008: Samejima Kumiko; Ogawa Hiromi; Cooke Carol A; Hudson Damien F; Macisaac Fiona; Ribeiro Susana A; Vagnarelli Paola; Cardinale Stefano; Kerr Alastair; Lai Fan; Ruchaud Sandrine; Yue Zuojun; Earnshaw William C
A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2457-62.
2008: Griffith Elen; Walker Sarah; Martin Carol-Anne; Vagnarelli Paola; Stiff Tom; Vernay Bertrand; Al Sanna Nouriya; Saggar Anand; Hamel Ben; Earnshaw William C; Jeggo Penny A; Jackson Andrew P; O'Driscoll Mark
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling.
Nature genetics 2008;40(2):232-6.
2007: Ruchaud Sandrine; Carmena Mar; Earnshaw William C
The chromosomal passenger complex: one for all and all for one.
Cell 2007;131(2):230-1.
2007: Ruchaud Sandrine; Carmena Mar; Earnshaw William C
Chromosomal passengers: conducting cell division.
Nature reviews. Molecular cell biology 2007;8(10):798-812.
2007: Toné Shigenobu; Sugimoto Kenji; Tanda Kazue; Suda Taiji; Uehira Kenzo; Kanouchi Hiroaki; Samejima Kumiko; Minatogawa Yohsuke; Earnshaw William C
Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis.
Experimental cell research 2007;313(16):3635-44.
2007: Ageichik Alexander V; Samejima Kumiko; Kaufmann Scott H; Earnshaw William C
Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells.
The Journal of biological chemistry 2007;282(37):27374-82.
2007: Faragher Alison J; Sun Xiao-Ming; Butterworth Michael; Harper Nick; Mulheran Mike; Ruchaud Sandrine; Earnshaw William C; Cohen Gerald M
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Molecular biology of the cell 2007;18(4):1337-47.
2007: Zachos George; Black Elizabeth J; Walker Mark; Scott Mary T; Vagnarelli Paola; Earnshaw William C; Gillespie David A F
Chk1 is required for spindle checkpoint function.
Developmental cell 2007;12(2):247-60.
2007: Rodríguez-Bayona Beatriz; Ruchaud Sandrine; Rodríguez Carmen; Linares Mario; Astola Antonio; Ortiz Manuela; Earnshaw William C; Valdivia Manuel M
Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.
Journal of autoimmune diseases 2007;4():1.
2006: Henzing Alexander J; Dodson Helen; Reid Joel M; Kaufmann Scott H; Baxter Robert L; Earnshaw William C
Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.
Journal of medicinal chemistry 2006;49(26):7636-45.
2006: Vagnarelli Paola; Hudson Damien F; Ribeiro Susana A; Trinkle-Mulcahy Laura; Spence Jennifer M; Lai Fan; Farr Christine J; Lamond Angus I; Earnshaw William C
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis.
Nature cell biology 2006;8(10):1133-42.
2006: Pereira Ana L; Pereira António J; Maia Ana R R; Drabek Ksenija; Sayas C Laura; Hergert Polla J; Lince-Faria Mariana; Matos Irina; Duque Cristina; Stepanova Tatiana; Rieder Conly L; Earnshaw William C; Galjart Niels; Maiato Helder
Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.
Molecular biology of the cell 2006;17(10):4526-42.
2006: Heale Jason T; Ball Alexander R; Schmiesing John A; Kim Jong-Soo; Kong Xiangduo; Zhou Sharleen; Hudson Damien F; Earnshaw William C; Yokomori Kyoko
Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair.
Molecular cell 2006;21(6):837-48.
2006: Chang Chih-Jui; Goulding Sarah; Adams Richard R; Earnshaw William C; Carmena Mar
Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system.
Journal of cell science 2006;119(Pt 6):1144-53.
2006: Ruchand Sandrine; Samejima Kumiko; Hudson Damien; Kaufmann Scott H; Earnshaw William C
Genetic analysis of apoptotic execution.
Sub-cellular biochemistry 2006;40():75-90.
2005: Earnshaw William C
Cell biology. Keeping survivin nimble at centromeres in mitosis.
Science (New York, N.Y.) 2005;310(5753):1443-4.
2005: Samejima Kumiko; Earnshaw William C
Trashing the genome: the role of nucleases during apoptosis.
Nature reviews. Molecular cell biology 2005;6(9):677-88.
2005: Goulding Sarah E; Earnshaw William C
Shugoshin: a centromeric guardian senses tension.
BioEssays : news and reviews in molecular, cellular and developmental biology 2005;27(6):588-91.
2005: Régnier Vinciane; Vagnarelli Paola; Fukagawa Tatsuo; Zerjal Tatiana; Burns Elizabeth; Trouche Didier; Earnshaw William; Brown William
CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.
Molecular and cellular biology 2005;25(10):3967-81.
2005: Gassmann Reto; Henzing Alexander J; Earnshaw William C
Novel components of human mitotic chromosomes identified by proteomic analysis of the chromosome scaffold fraction.
Chromosoma 2005;113(7):385-97.
2004: Maiato Helder; DeLuca Jennifer; Salmon E D; Earnshaw William C
The dynamic kinetochore-microtubule interface.
Journal of cell science 2004;117(Pt 23):5461-77.
2004: Vagnarelli Paola; Earnshaw William C
Chromosomal passengers: the four-dimensional regulation of mitotic events.
Chromosoma 2004;113(5):211-22.
2004: Dodson Helen; Bourke Emer; Jeffers Liam J; Vagnarelli Paola; Sonoda Eiichiro; Takeda Shunichi; Earnshaw William C; Merdes Andreas; Morrison Ciaran
Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.
The EMBO journal 2004;23(19):3864-73.
2004: Gassmann Reto; Carvalho Ana; Henzing Alexander J; Ruchaud Sandrine; Hudson Damien F; Honda Reiko; Nigg Erich A; Gerloff Dietlind L; Earnshaw William C
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.
The Journal of cell biology 2004;166(2):179-91.
2004: Gassmann Reto; Vagnarelli Paola; Hudson Damien; Earnshaw William C
Mitotic chromosome formation and the condensin paradox.
Experimental cell research 2004;296(1):35-42.
2004: Vagnarelli Paola; Morrison Ciaran; Dodson Helen; Sonoda Eiichiro; Takeda Shunichi; Earnshaw William C
Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores.
EMBO reports 2004;5(2):167-71.
2004: Wheatley Sally P; Henzing Alexander J; Dodson Helen; Khaled Walid; Earnshaw William C
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.
The Journal of biological chemistry 2004;279(7):5655-60.
2004: Korfali Nadia; Ruchaud Sandrine; Loegering David; Bernard Delphine; Dingwall Colin; Kaufmann Scott H; Earnshaw William C
Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.
The Journal of biological chemistry 2004;279(2):1030-9.
2003: Chang Chih-Jui; Goulding Sarah; Earnshaw William C; Carmena Mar
RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate.
Journal of cell science 2003;116(Pt 23):4715-26.
2003: Carmena Mar; Earnshaw William C
The cellular geography of aurora kinases.
Nature reviews. Molecular cell biology 2003;4(11):842-54.
2003: Maiato Helder; Rieder Conly L; Earnshaw William C; Sunkel Claudio E
How do kinetochores CLASP dynamic microtubules?
Cell cycle (Georgetown, Tex.) 2003;2(6):511-4.
2003: Hudson Damien F; Vagnarelli Paola; Gassmann Reto; Earnshaw William C
Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes.
Developmental cell 2003;5(2):323-36.
2003: Carvalho Ana; Carmena Mar; Sambade Clara; Earnshaw William C; Wheatley Sally P
Survivin is required for stable checkpoint activation in taxol-treated HeLa cells.
Journal of cell science 2003;116(Pt 14):2987-98.
2003: Maiato Helder; Fairley Elizabeth A L; Rieder Conly L; Swedlow Jason R; Sunkel Claudio E; Earnshaw William C
Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.
Cell 2003;113(7):891-904.
2003: Earnshaw William C; Carmena Mar
A perfect funeral with no corpse.
The Journal of cell biology 2003;160(7):989-90.
2003: Morrison C; Vagnarelli P; Sonoda E; Takeda S; Earnshaw W C
Sister chromatid cohesion and genome stability in vertebrate cells.
Biochemical Society transactions 2003;31(Pt 1):263-5.
2002: Morrison Ciaran; Henzing Alexander J; Jensen Ole Nørregaard; Osheroff Neil; Dodson Helen; Kandels-Lewis Stefanie E; Adams Richard R; Earnshaw William C
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.
Nucleic acids research 2002;30(23):5318-27.
2002: Spence Jennifer M; Critcher Ricky; Ebersole Thomas A; Valdivia Manuel M; Earnshaw William C; Fukagawa Tatsuo; Farr Christine J
Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array.
The EMBO journal 2002;21(19):5269-80.
2002: Hudson Damien F; Morrison Ciaran; Ruchaud Sandrine; Earnshaw William C
Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'.
Trends in cell biology 2002;12(6):281-7.
2002: Maiato Helder; Sampaio Paula; Lemos Catarina L; Findlay John; Carmena Mar; Earnshaw William C; Sunkel Claudio E
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.
The Journal of cell biology 2002;157(5):749-60.
2002: Nishihashi Ai; Haraguchi Tokuko; Hiraoka Yasushi; Ikemura Toshimichi; Regnier Vinciane; Dodson Helen; Earnshaw William C; Fukagawa Tatsuo
CENP-I is essential for centromere function in vertebrate cells.
Developmental cell 2002;2(4):463-76.
2002: Ruchaud Sandrine; Korfali Nadia; Villa Pascal; Kottke Timothy J; Dingwall Colin; Kaufmann Scott H; Earnshaw William C
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.
The EMBO journal 2002;21(8):1967-77.
2002: Mejía José E; Alazami Anas; Willmott Adrian; Marschall Peter; Levy Elaine; Earnshaw William C; Larin Zoia
Efficiency of de novo centromere formation in human artificial chromosomes.
Genomics 2002;79(3):297-304.
2002: Jullien Denis; Vagnarelli Paola; Earnshaw William C; Adachi Yasuhisa
Kinetochore localisation of the DNA damage response component 53BP1 during mitosis.
Journal of cell science 2002;115(Pt 1):71-9.
2002: Kottke Timothy J; Blajeski April L; Meng X Wei; Svingen Phyllis A; Ruchaud Sandrine; Mesner Peter W; Boerner Scott A; Samejima Kumiko; Henriquez Nicholas V; Chilcote Tamie J; Lord Janet; Salmon Michael; Earnshaw William C; Kaufmann Scott H
Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells.
The Journal of biological chemistry 2002;277(1):804-15.
2001: Sonoda E; Matsusaka T; Morrison C; Vagnarelli P; Hoshi O; Ushiki T; Nojima K; Fukagawa T; Waizenegger I C; Peters J M; Earnshaw W C; Takeda S
Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells.
Developmental cell 2001;1(6):759-70.
2001: Vagnarelli P B; Earnshaw W C
INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion.
Chromosoma 2001;110(6):393-401.
2001: Samejima K; Tone S; Earnshaw W C
CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis.
The Journal of biological chemistry 2001;276(48):45427-32.
2001: Van Hooser A A; Ouspenski I I; Gregson H C; Starr D A; Yen T J; Goldberg M L; Yokomori K; Earnshaw W C; Sullivan K F; Brinkley B R
Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A.
Journal of cell science 2001;114(Pt 19):3529-42.
2001: Earnshaw W C
Chromosomal passengers.
Current biology : CB 2001;11(17):R683.
2001: Kaufmann S H; Kottke T J; Martins L M; Henzing A J; Earnshaw W C
Analysis of caspase activation during apoptosis.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2001;Chapter 18():Unit 18.2.
2001: Mejía J E; Willmott A; Levy E; Earnshaw W C; Larin Z
Functional complementation of a genetic deficiency with human artificial chromosomes.
American journal of human genetics 2001;69(2):315-26.
2001: Wheatley S P; Carvalho A; Vagnarelli P; Earnshaw W C
INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.
Current biology : CB 2001;11(11):886-90.
2001: Adams R R; Eckley D M; Vagnarelli P; Wheatley S P; Gerloff D L; Mackay A M; Svingen P A; Kaufmann S H; Earnshaw W C
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
Chromosoma 2001;110(2):65-74.
2001: Adams R R; Maiato H; Earnshaw W C; Carmena M
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
The Journal of cell biology 2001;153(4):865-80.
2001: Adams R R; Carmena M; Earnshaw W C
Chromosomal passengers and the (aurora) ABCs of mitosis.
Trends in cell biology 2001;11(2):49-54.
2001: Wheatley S P; Kandels-Lewis S E; Adams R R; Ainsztein A M; Earnshaw W C
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.
Experimental cell research 2001;262(2):122-7.
2000: Petruti-Mot A S; Earnshaw W C
Two differentially spliced forms of topoisomerase IIalpha and beta mRNAs are conserved between birds and humans.
Gene 2000;258(1-2):183-92.
2000: Adams R R; Wheatley S P; Gouldsworthy A M; Kandels-Lewis S E; Carmena M; Smythe C; Gerloff D L; Earnshaw W C
INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.
Current biology : CB 2000;10(17):1075-8.
2000: Durrieu F; Samejima K; Fortune J M; Kandels-Lewis S; Osheroff N; Earnshaw W C
DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution.
Current biology : CB 2000;10(15):923-6.
2000: Earnshaw W C; Samejima K; Durrieu F; Fortune J; Osheroff N
Biochemical mechanism of apoptotic execution.
Annales d'endocrinologie 2000;61(2):137.
2000: Merdes A; Heald R; Samejima K; Earnshaw W C; Cleveland D W
Formation of spindle poles by dynein/dynactin-dependent transport of NuMA.
The Journal of cell biology 2000;149(4):851-62.
2000: Kaufmann S H; Earnshaw W C
Induction of apoptosis by cancer chemotherapy.
Experimental cell research 2000;256(1):42-9.
2000: Samejima K; Earnshaw W C
Differential localization of ICAD-L and ICAD-S in cells due to removal of a C-terminal NLS from ICAD-L by alternative splicing.
Experimental cell research 2000;255(2):314-20.
2000: Floridia G; Gimelli G; Zuffardi O; Earnshaw W C; Warburton P E; Tyler-Smith C
A neocentromere in the DAZ region of the human Y chromosome.
Chromosoma 2000;109(5):318-27.
2000: Kaufmann S H; Mesner P W; Samejima K; Toné S; Earnshaw W C
Detection of DNA cleavage in apoptotic cells.
Methods in enzymology 2000;322():3-15.
1999: Everett R D; Earnshaw W C; Pluta A F; Sternsdorf T; Ainsztein A M; Carmena M; Ruchaud S; Hsu W L; Orr A
A dynamic connection between centromeres and ND10 proteins.
Journal of cell science 1999;112 ( Pt 20)():3443-54.
1999: Mesner P W; Bible K C; Martins L M; Kottke T J; Srinivasula S M; Svingen P A; Chilcote T J; Basi G S; Tung J S; Krajewski S; Reed J C; Alnemri E S; Earnshaw W C; Kaufmann S H
Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile.
The Journal of biological chemistry 1999;274(32):22635-45.
1999: Kottke T J; Blajeski A L; Martins L M; Mesner P W; Davidson N E; Earnshaw W C; Armstrong D K; Kaufmann S H
Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis.
The Journal of biological chemistry 1999;274(22):15927-36.
1999: Tyler-Smith C; Gimelli G; Giglio S; Floridia G; Pandya A; Terzoli G; Warburton P E; Earnshaw W C; Zuffardi O
Transmission of a fully functional human neocentromere through three generations.
American journal of human genetics 1999;64(5):1440-4.
1999: Everett R D; Earnshaw W C; Findlay J; Lomonte P
Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110.
The EMBO journal 1999;18(6):1526-38.
1999: Samejima K; Svingen P A; Basi G S; Kottke T; Mesner P W; Stewart L; Durrieu F; Poirier G G; Alnemri E S; Champoux J J; Kaufmann S H; Earnshaw W C
Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis.
The Journal of biological chemistry 1999;274(7):4335-40.
1999: Craig J M; Earnshaw W C; Vagnarelli P
Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression.
Experimental cell research 1999;246(2):249-62.
1999: Earnshaw W C; Martins L M; Kaufmann S H
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
Annual review of biochemistry 1999;68():383-424.
1998: Jablonski S A; Chan G K; Cooke C A; Earnshaw W C; Yen T J
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis.
Chromosoma 1998;107(6-7):386-96.
1998: Ainsztein A M; Kandels-Lewis S E; Mackay A M; Earnshaw W C
INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.
The Journal of cell biology 1998;143(7):1763-74.
1998: Martins L M; Kottke T J; Kaufmann S H; Earnshaw W C
Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis.
Blood 1998;92(9):3042-9.
1998: Samejima K; Toné S; Kottke T J; Enari M; Sakahira H; Cooke C A; Durrieu F; Martins L M; Nagata S; Kaufmann S H; Earnshaw W C
Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.
The Journal of cell biology 1998;143(1):225-39.
1998: Samejima K; Earnshaw W C
ICAD/DFF regulator of apoptotic nuclease is nuclear.
Experimental cell research 1998;243(2):453-9.
1998: Pluta A F; Earnshaw W C; Goldberg I G
Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.
Journal of cell science 1998;111 ( Pt 14)():2029-41.
1998: Mackay A M; Ainsztein A M; Eckley D M; Earnshaw W C
A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis.
The Journal of cell biology 1998;140(5):991-1002.
1997: Cooke C A; Schaar B; Yen T J; Earnshaw W C
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase.
Chromosoma 1997;106(7):446-55.
1997: Martins L M; Mesner P W; Kottke T J; Basi G S; Sinha S; Tung J S; Svingen P A; Madden B J; Takahashi A; McCormick D J; Earnshaw W C; Kaufmann S H
Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis.
Blood 1997;90(11):4283-96.
1997: Warburton P E; Cooke C A; Bourassa S; Vafa O; Sullivan B A; Stetten G; Gimelli G; Warburton D; Tyler-Smith C; Sullivan K F; Poirier G G; Earnshaw W C
Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres.
Current biology : CB 1997;7(11):901-4.
1997: Eischen C M; Kottke T J; Martins L M; Basi G S; Tung J S; Earnshaw W C; Leibson P J; Kaufmann S H
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Blood 1997;90(3):935-43.
1997: Eckley D M; Ainsztein A M; Mackay A M; Goldberg I G; Earnshaw W C
Chromosomal proteins and cytokinesis: patterns of cleavage furrow formation and inner centromere protein positioning in mitotic heterokaryons and mid-anaphase cells.
The Journal of cell biology 1997;136(6):1169-83.
1997: Martins L M; Kottke T; Mesner P W; Basi G S; Sinha S; Frigon N; Tatar E; Tung J S; Bryant K; Takahashi A; Svingen P A; Madden B J; McCormick D J; Earnshaw W C; Kaufmann S H
Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis.
The Journal of biological chemistry 1997;272(11):7421-30.
1997: Takahashi A; Goldschmidt-Clermont P J; Alnemri E S; Fernandes-Alnemri T; Yoshizawa-Kumagaya K; Nakajima K; Sasada M; Poirier G G; Earnshaw W C
Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide.
Experimental cell research 1997;231(1):123-31.
1997: Warburton P E; Earnshaw W C
Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(2):97-9.
1996: Takahashi A; Musy P Y; Martins L M; Poirier G G; Moyer R W; Earnshaw W C
CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation.
The Journal of biological chemistry 1996;271(51):32487-90.
1996: Goldberg I G; Sawhney H; Pluta A F; Warburton P E; Earnshaw W C
Surprising deficiency of CENP-B binding sites in African green monkey alpha-satellite DNA: implications for CENP-B function at centromeres.
Molecular and cellular biology 1996;16(9):5156-68.
1996: Takahashi A; Alnemri E S; Lazebnik Y A; Fernandes-Alnemri T; Litwack G; Moir R D; Goldman R D; Poirier G G; Kaufmann S H; Earnshaw W C
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8395-400.
1996: Pluta A F; Earnshaw W C
Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator.
The Journal of biological chemistry 1996;271(31):18767-74.
1996: Yang C H; Tomkiel J; Saitoh H; Johnson D H; Earnshaw W C
Identification of overlapping DNA-binding and centromere-targeting domains in the human kinetochore protein CENP-C.
Molecular and cellular biology 1996;16(7):3576-86.
1996: Malek S N; Yang C H; Earnshaw W C; Kozak C A; Desiderio S
p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
The Journal of biological chemistry 1996;271(12):6952-62.
1996: Takahashi A; Earnshaw W C
ICE-related proteases in apoptosis.
Current opinion in genetics & development 1996;6(1):50-5.
1995: Pluta A F; Mackay A M; Ainsztein A M; Goldberg I G; Earnshaw W C
The centromere: hub of chromosomal activities.
Science (New York, N.Y.) 1995;270(5242):1591-4.
1995: Saitoh N; Goldberg I; Earnshaw W C
The SMC proteins and the coming of age of the chromosome scaffold hypothesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(9):759-66.
1995: Lazebnik Y A; Takahashi A; Moir R D; Goldman R D; Poirier G G; Kaufmann S H; Earnshaw W C
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9042-6.
1995: Earnshaw W C
Nuclear changes in apoptosis.
Current opinion in cell biology 1995;7(3):337-43.
1995: Tugendreich S; Tomkiel J; Earnshaw W; Hieter P
CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition.
Cell 1995;81(2):261-8.
1995: Vázquez-Abad D; Russell C A; Cusick S M; Earnshaw W C; Rothfield N F
Longitudinal study of anticentromere and antitopoisomerase-I isotypes.
Clinical immunology and immunopathology 1995;74(3):257-70.
1995: Lazebnik Y A; Takahashi A; Poirier G G; Kaufmann S H; Earnshaw W C
Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells.
Journal of cell science. Supplement 1995;19():41-9.
1994: Saitoh N; Goldberg I G; Wood E R; Earnshaw W C
ScII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure.
The Journal of cell biology 1994;127(2):303-18.
1994: Lazebnik Y A; Kaufmann S H; Desnoyers S; Poirier G G; Earnshaw W C
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE.
Nature 1994;371(6495):346-7.
1994: Earnshaw W C; Mackay A M
Role of nonhistone proteins in the chromosomal events of mitosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(12):947-56.
1994: Earnshaw W C; Pluta A F
Mitosis.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(9):639-43.
1994: Tomkiel J; Cooke C A; Saitoh H; Bernat R L; Earnshaw W C
CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase.
The Journal of cell biology 1994;125(3):531-45.
1994: Vázquez-Abad D; Wallace S; Senécal J L; Joyal F; Roussin A; Earnshaw W C; Rothfield N
Anticentromere autoantibodies. Evaluation of an ELISA using recombinant fusion protein CENP-B as antigen.
Arthritis and rheumatism 1994;37(2):248-52.
1993: Mackay A M; Eckley D M; Chue C; Earnshaw W C
Molecular analysis of the INCENPs (inner centromere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase.
The Journal of cell biology 1993;123(2):373-85.
1993: Lazebnik Y A; Cole S; Cooke C A; Nelson W G; Earnshaw W C
Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.
The Journal of cell biology 1993;123(1):7-22.
1993: Saunders W S; Chue C; Goebl M; Craig C; Clark R F; Powers J A; Eissenberg J C; Elgin S C; Rothfield N F; Earnshaw W C
Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.
Journal of cell science 1993;104 ( Pt 2)():573-82.
1993: Jabs E W; Tuck-Muller C M; Anhalt G J; Earnshaw W; Wise R A; Wigley F
Cytogenetic survey in systemic sclerosis: correlation of aneuploidy with the presence of anticentromere antibodies.
Cytogenetics and cell genetics 1993;63(3):169-75.
1993: Mackay A M; Earnshaw W C
The INCENPs: structural and functional analysis of a family of chromosome passenger proteins.
Cold Spring Harbor symposia on quantitative biology 1993;58():697-706.
1992: Saitoh H; Tomkiel J; Cooke C A; Ratrie H; Maurer M; Rothfield N F; Earnshaw W C
CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.
Cell 1992;70(1):115-25.
1992: Pluta A F; Saitoh N; Goldberg I; Earnshaw W C
Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere.
The Journal of cell biology 1992;116(5):1081-93.
1992: Earnshaw W C; Tomkiel J E
Centromere and kinetochore structure.
Current opinion in cell biology 1992;4(1):86-93.
1991: Saunders W S; Cooke C A; Earnshaw W C
Compartmentalization within the nucleus: discovery of a novel subnuclear region.
The Journal of cell biology 1991;115(4):919-31.
1991: Bernat R L; Delannoy M R; Rothfield N F; Earnshaw W C
Disruption of centromere assembly during interphase inhibits kinetochore morphogenesis and function in mitosis.
Cell 1991;66(6):1229-38.
1991: Yen T J; Compton D A; Wise D; Zinkowski R P; Brinkley B R; Earnshaw W C; Cleveland D W
CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.
The EMBO journal 1991;10(5):1245-54.
1991: Earnshaw W C
When is a centromere not a kinetochore?
Journal of cell science 1991;99 ( Pt 1)():1-4.
1991: Earnshaw W C; Cooke C A
Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation.
Journal of cell science 1991;98 ( Pt 4)():443-61.
1991: Earnshaw W C; Bernat R L
Chromosomal passengers: toward an integrated view of mitosis.
Chromosoma 1991;100(3):139-46.
1991: Weiner E S; Hildebrandt S; Senécal J L; Daniels L; Noell S; Joyal F; Roussin A; Earnshaw W; Rothfield N F
Prognostic significance of anticentromere antibodies and anti-topoisomerase I antibodies in Raynaud's disease. A prospective study.
Arthritis and rheumatism 1991;34(1):68-77.
1991: Earnshaw W C; Bernat R L; Cooke C A; Rothfield N F
Role of the centromere/kinetochore in cell cycle control.
Cold Spring Harbor symposia on quantitative biology 1991;56():675-85.
1991: Hildebrandt S; Noell G S; Vazquez-Abad D; Earnshaw W C; Zanetti M; Rothfield N F
Idiotypic analysis of human anti-topoisomerase I autoantibodies.
Autoimmunity 1991;10(1):41-8.
1991: Hildebrandt S; Weiner E S; Earnshaw W C; Zanetti M; Rothfield N F
Idiotypic analysis of human anticentromere autoantibodies.
Autoimmunity 1991;9(2):131-40.
1990: Wood E R; Earnshaw W C
Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II.
The Journal of cell biology 1990;111(6 Pt 2):2839-50.
1990: Hildebrandt S; Weiner E S; Senecal J L; Noell G S; Earnshaw W C; Rothfield N F
Autoantibodies to topoisomerase I (Scl-70): analysis by gel diffusion, immunoblot, and enzyme-linked immunosorbent assay.
Clinical immunology and immunopathology 1990;57(3):399-410.
1990: Bernat R L; Borisy G G; Rothfield N F; Earnshaw W C
Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis.
The Journal of cell biology 1990;111(4):1519-33.
1990: D'Arpa P; White-Cooper H; Cleveland D W; Rothfield N F; Earnshaw W C
Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients.
Arthritis and rheumatism 1990;33(10):1501-11.
1990: Cooke C A; Bernat R L; Earnshaw W C
CENP-B: a major human centromere protein located beneath the kinetochore.
The Journal of cell biology 1990;110(5):1475-88.
1990: Hildebrandt S; Weiner E; Senécal J L; Noell S; Daniels L; Earnshaw W C; Rothfield N F
The IgG, IgM, and IgA isotypes of anti-topoisomerase I and anticentromere autoantibodies.
Arthritis and rheumatism 1990;33(5):724-7.
1989: Eisenberg R A; Earnshaw W C; Bordwell B J; Craven S Y; Cheek R; Rothfield N F
Isotype analysis of the anti-CENP-B anticentromere autoantibody: evidence for restricted clonality.
Arthritis and rheumatism 1989;32(10):1315-8.
1989: Heck M M; Hittelman W N; Earnshaw W C
In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II. Cell cycle analysis.
The Journal of biological chemistry 1989;264(26):15161-4.
1989: Earnshaw W C; Ratrie H; Stetten G
Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads.
Chromosoma 1989;98(1):1-12.
1989: Wong C; Kazazian H H; Stetten G; Earnshaw W C; Van Keuren M L; Antonarakis S E
Molecular mechanism in the formation of a human ring chromosome 21.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):1914-8.
1989: Hoffmann A; Heck M M; Bordwell B J; Rothfield N F; Earnshaw W C
Human autoantibody to topoisomerase II.
Experimental cell research 1989;180(2):409-18.
1989: Earnshaw W C; Cooke C A
Proteins of the inner and outer centromere of mitotic chromosomes.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(2):541-52.
1989: Earnshaw W C; Rattner J B
A map of the centromere (primary constriction) in vertebrate chromosomes at metaphase.
Progress in clinical and biological research 1989;318():33-42.
1988: D'Arpa P; Machlin P S; Ratrie H; Rothfield N F; Cleveland D W; Earnshaw W C
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2543-7.
1988: Weiner E S; Earnshaw W C; Senécal J L; Bordwell B; Johnson P; Rothfield N F
Clinical associations of anticentromere antibodies and antibodies to topoisomerase I. A study of 355 patients.
Arthritis and rheumatism 1988;31(3):378-85.
1988: Heck M M; Hittelman W N; Earnshaw W C
Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1086-90.
1987: Rothfield N; Whitaker D; Bordwell B; Weiner E; Senecal J L; Earnshaw W
Detection of anticentromere antibodies using cloned autoantigen CENP-B.
Arthritis and rheumatism 1987;30(12):1416-9.
1987: Cooke C A; Heck M M; Earnshaw W C
The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.
The Journal of cell biology 1987;105(5):2053-67.
1987: Earnshaw W C
Anionic regions in nuclear proteins.
The Journal of cell biology 1987;105(4):1479-82.
1987: Earnshaw W C; Machlin P S; Bordwell B J; Rothfield N F; Cleveland D W
Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(14):4979-83.
1987: Shero J H; Bordwell B; Rothfield N F; Earnshaw W C
Antibodies to topoisomerase I in sera from patients with scleroderma.
The Journal of rheumatology. Supplement 1987;14 Suppl 13():138-40.
1987: Earnshaw W C; Sullivan K F; Machlin P S; Cooke C A; Kaiser D A; Pollard T D; Rothfield N F; Cleveland D W
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen.
The Journal of cell biology 1987;104(4):817-29.
1986: Earnshaw W; Bordwell B; Marino C; Rothfield N
Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies.
The Journal of clinical investigation 1986;77(2):426-30.
1986: Shero J H; Bordwell B; Rothfield N F; Earnshaw W C
High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients.
Science (New York, N.Y.) 1986;231(4739):737-40.
1985: Earnshaw W C; Halligan B; Cooke C A; Heck M M; Liu L F
Topoisomerase II is a structural component of mitotic chromosome scaffolds.
The Journal of cell biology 1985;100(5):1706-15.

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