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Wolfgang Eberhardt

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Kai Doberstein; Wolfgang Eberhardt; Roman Blaheta; Patrick N Harter; Ann-Kathrin Hartmetz; Eva Juengel; Michel Mittelbronn; Josef Pfeilschifter; Nico Steinmeyer; Paul Gutwein
MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.
Wolfgang Eberhardt; Anke Doller; Josef Pfeilschifter
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation.
Bashier Ibrahim Osman; El-Sayed Akool; Anke Doller; Roswitha Müller; Josef Pfeilschifter; Wolfgang Eberhardt
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin.

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All Publications

2013: Kai Doberstein; Wolfgang Eberhardt; Roman Blaheta; Patrick N Harter; Ann-Kathrin Hartmetz; Eva Juengel; Michel Mittelbronn; Josef Pfeilschifter; Nico Steinmeyer; Paul Gutwein
MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients.
Neoplasia (New York, N.Y.) 2013;15(2):218-30.
2012: Wolfgang Eberhardt; Anke Doller; Josef Pfeilschifter
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation.
Current protein & peptide science 2012;13(4):380-90.
2011: Bashier Ibrahim Osman; El-Sayed Akool; Anke Doller; Roswitha Müller; Josef Pfeilschifter; Wolfgang Eberhardt
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin.
Biochemical pharmacology 2011;81(1):134-43.
2010: Anke Doller; Kai Schlepckow; Harald Schwalbe; Josef Pfeilschifter; Wolfgang Eberhardt
Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.
Molecular and cellular biology 2010;30(6):1397-410.
2009: Bashier Ibrahim Osman; Anke Doller; El-Sayed Akool; Martin Holdener; Edith Hintermann; Josef Pfeilschifter; Wolfgang Eberhardt
Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR.
Cellular signalling 2009;21(12):1806-17.
2009: Shuyu Ren; Andrea Babelova; Kristin Moreth; Cuiyan Xin; Wolfgang Eberhardt; Anke Doller; Hermann Pavenstädt; Liliana Schaefer; Josef Pfeilschifter; Andrea Huwiler
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Kidney international 2009;76(8):857-67.
2009: Christine Jespersen; Anke Doller; El-Sayed Akool; Malte Bachmann; Roswitha Müller; Paul Gutwein; Heiko Muhl; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.
Journal of cellular physiology 2009;219(2):276-87.
2009: Anke Doller; Stefan Gauer; Ewelina Sobkowiak; Helmut Geiger; Josef Pfeilschifter; Wolfgang Eberhardt
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
The American journal of pathology 2009;174(4):1252-63.
2008: Anke Doller; Josef Pfeilschifter; Wolfgang Eberhardt
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.
Cellular signalling 2008;20(12):2165-73.
2008: El-Sayed Akool; Anke Doller; Andrea Babelova; Wasiliki Tsalastra; Kristin Moreth; Liliana Schaefer; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2831-45.
2008: Anke Doller; El-Sayed Akool; Andrea Huwiler; Roswitha Müller; Heinfried Radeke; Josef Pfeilschifter; Wolfgang Eberhardt
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.
Molecular and cellular biology 2008;28(8):2608-25.
2008: Axel M Johann; Andreas Weigert; Wolfgang Eberhardt; Anne-Marie Kuhn; Vera Barra; Andreas von Knethen; Josef M Pfeilschifter; Bernhard Brüne
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1239-48.
2008: Christian Sadik; Klaus-Peter Hunfeld; Malte Bachmann; Peter Kraiczy; Wolfgang Eberhardt; Volker Brade; Josef Pfeilschifter; Heiko Muhl
Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates.
The international journal of biochemistry & cell biology 2008;40(11):2508-21.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Journal of lipid research 2007;48(9):1985-96.
2007: Anke Doller; Andrea Huwiler; Roswitha Müller; Heinfried Radeke; Josef Pfeilschifter; Wolfgang Eberhardt
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2.
Molecular biology of the cell 2007;18(6):2137-48.
2007: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
British journal of pharmacology 2007;150(7):943-50.
2007: Wolfgang Eberhardt; Anke Doller; El-Sayed Akool; Josef Pfeilschifter
Modulation of mRNA stability as a novel therapeutic approach.
Pharmacology & therapeutics 2007;114(1):56-73.
2007: Anke Doller; El-Sayed Akool; Roswitha Müller; Paul Gutwein; Christine Kurowski; Josef Pfeilschifter; Wolfgang Eberhardt
Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells.
Journal of the American Society of Nephrology : JASN 2007;18(2):581-92.
2006: Cuiyan Xin; Shuyu Ren; Wolfgang Eberhardt; Josef Pfeilschifter; Andrea Huwiler
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
British journal of pharmacology 2006;147(2):164-74.
2005: El-Sayed Akool; Anke Doller; Roswitha Müller; Paul Gutwein; Cuiyan Xin; Andrea Huwiler; Josef Pfeilschifter; Wolfgang Eberhardt
Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.
The Journal of biological chemistry 2005;280(47):39403-16.
2005: Claudia Nold-Petry; Andrea Huwiler; Wolfgang Eberhardt; Marietta Kaszkin; Josef Pfeilschifter
Hypoxia increases group IIA phospholipase A(2) expression under inflammatory conditions in rat renal mesangial cells.
Journal of the American Society of Nephrology : JASN 2005;16(10):2897-905.
2005: Wolfgang Eberhardt; Tobias Kilz; El-Sayed Akool; Roswitha Müller; Josef Pfeilschifter
Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells.
Biochemical pharmacology 2005;70(3):433-45.
2004: Cuiyan Xin; Shuyu Ren; Burkhard Kleuser; Soheyla Shabahang; Wolfgang Eberhardt; Heinfried Radeke; Monika Schäfer-Korting; Josef Pfeilschifter; Andrea Huwiler
Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
The Journal of biological chemistry 2004;279(34):35255-62.
2004: Marietta Kaszkin; Karl-Friedrich Beck; Wolfgang Eberhardt; Josef Pfeilschifter
Unravelling green tea's mechanisms of action: more than meets the eye.
Molecular pharmacology 2004;65(1):15-7.
2003: Andrea Huwiler; El-Sayed Akool; S. Armaz Aschrafi; Farid M A Hamada; Josef Pfeilschifter; Wolfgang Eberhardt
ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.
The Journal of biological chemistry 2003;278(51):51758-69.
2003: Marcel Nold; Ingeborg A Hauser; Sonja Höfler; Andreas Goede; Wolfgang Eberhardt; Tilmann Ditting; Helmut Geiger; Josef Pfeilschifter; Heiko Muhl
IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood.
Biochemical pharmacology 2003;66(3):505-10.
2003: Josef Pfeilschifter; Wolfgang Eberhardt; Andrea Huwiler
Nitric oxide and mechanisms of redox signaling.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S237-40.
2003: El-Sayed Akool; Hartmut Kleinert; Farid M A Hamada; Mohamed H Abdelwahab; Ulrich Förstermann; Josef Pfeilschifter; Wolfgang Eberhardt
Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology 2003;23(14):4901-16.
2003: Stefan Gauer; Andrea Hartner; Ingeborg A Hauser; Wolfgang Fierlbeck; Wolfgang Eberhardt; Helmut Geiger
Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats.
American journal of hypertension 2003;16(3):214-22.
2003: Wolfgang Eberhardt; Tobias Kilz
[On genomic and nongenomic effects. Molecular basis of glucocorticoid action].
Pharmazie in unserer Zeit 2003;32(4):288-94.
2003: Marcel Nold; Andreas Goede; Wolfgang Eberhardt; Josef Pfeilschifter; Heiko Muhl
IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: suppression by TNF alpha blockage and modulation by IL-10.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):68-75.
2003: Josef Pfeilschifter; Wolfgang Eberhardt; Karl-Friedrich Beck; Andrea Huwiler
Redox signaling in mesangial cells.
Nephron. Experimental nephrology 2003;93(1):e23-6.
2002: Wolfgang Eberhardt; El-Sayed Akool; Jorg Rebhan; Stefan Frank; Karl-Friedrich Beck; Rochus Franzen; Farid M A Hamada; Josef Pfeilschifter
Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability.
The Journal of biological chemistry 2002;277(36):33518-28.
2002: Wolfgang Eberhardt; Christina Engels; Roswitha Müller; Josef Pfeilschifter
Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells.
Kidney international 2002;62(3):809-21.
2002: Wolfgang Eberhardt; Maja Schulze; Christina Engels; Elke Klasmeier; Josef Pfeilschifter
Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1752-66.
2002: Josef Pfeilschifter; Karl-Friedrich Beck; Wolfgang Eberhardt; Andrea Huwiler
Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.
Kidney international 2002;61(3):809-15.
2002: Wolfgang Eberhardt; Karl-Friedrich Beck; Josef Pfeilschifter
Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells.
Kidney international 2002;61(1):20-30.
2001: Karl-Friedrich Beck; Sebastian Walpen; Wolfgang Eberhardt; Josef Pfeilschifter
Downregulation of integrin-linked kinase mRNA expression by nitric oxide in rat glomerular mesangial cells.
Life sciences 2001;69(25-26):2945-55.
2001: Sebastian Walpen; Karl-Friedrich Beck; Liliana Schaefer; Igor Raslik; Wolfgang Eberhardt; Roland M Schaefer; Josef Pfeilschifter
Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):571-3.
2000: Wolfgang Eberhardt; Andrea Huwiler; Karl-Friedrich Beck; Sebastian Walpen; Josef Pfeilschifter
Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5788-97.
2000: Kristen Scholz-Pedretti; Wolfgang Eberhardt; G Rupprecht; Karl-Friedrich Beck; S Spitzer; Josef Pfeilschifter; Marietta Kaszkin
Inhibition of NFkappaB-mediated pro-inflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4, 6-dione-5-carboxamide, CGP-43182.
British journal of pharmacology 2000;130(5):1183-90.
2000: Sebastian Walpen; Karl-Friedrich Beck; Wolfgang Eberhardt; M Apel; P K Chatterjee; G M Wray; Christoph Thiemermann; Josef Pfeilschifter
Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat.
Journal of the American Society of Nephrology : JASN 2000;11(3):468-76.
2000: Wolfgang Eberhardt; Thomas Beeg; Karl-Friedrich Beck; Sebastian Walpen; Stefan Gauer; Hansjosef Böhles; Josef Pfeilschifter
Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells.
Kidney international 2000;57(1):59-69.
1999: Heiko Muhl; Marcel Nold; Jae-Hyung Chang; Stefan Frank; Wolfgang Eberhardt; Josef Pfeilschifter
Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells.
European journal of immunology 1999;29(10):3225-35.
1999: Karl-Friedrich Beck; Wolfgang Eberhardt; Stefan Frank; Andrea Huwiler; UK Messmer; Heiko Muhl; Josef Pfeilschifter
Inducible NO synthase: role in cellular signalling.
The Journal of experimental biology 1999;202(Pt 6):645-53.
1998: Karl-Friedrich Beck; Wolfgang Eberhardt; Sebastian Walpen; M Apel; Josef Pfeilschifter
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells.
FEBS letters 1998;435(1):35-8.
1998: Wolfgang Eberhardt; C Plüss; R Hummel; Josef Pfeilschifter
Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4961-9.
1997: D Kunz; G Walker; Wolfgang Eberhardt; UK Messmer; Andrea Huwiler; Josef Pfeilschifter
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
The Journal of clinical investigation 1997;100(11):2800-9.
1996: Wolfgang Eberhardt; D Kunz; R Hummel; Josef Pfeilschifter
Molecular cloning of the rat inducible nitric oxide synthase gene promoter.
Biochemical and biophysical research communications 1996;223(3):752-6.
1996: D Kunz; G Walker; Wolfgang Eberhardt; Josef Pfeilschifter
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):255-9.
1996: Josef Pfeilschifter; Wolfgang Eberhardt; R Hummel; D Kunz; Heiko Muhl; D Nitsch; C Plüss; G Walker
Therapeutic strategies for the inhibition of inducible nitric oxide synthase--potential for a novel class of anti-inflammatory agents.
Cell biology international 1996;20(1):51-8.
1995: D Kunz; G Walker; Wolfgang Eberhardt; D Nitsch; Josef Pfeilschifter
Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A.
Biochemical and biophysical research communications 1995;216(2):438-46.
1994: Wolfgang Eberhardt; D Kunz; Josef Pfeilschifter
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.
Biochemical and biophysical research communications 1994;200(1):163-70.
1994: Josef Pfeilschifter; D Kunz; Heiko Muhl; Wolfgang Eberhardt
Cytokine regulation of nitric oxide synthase expression in glomerular mesangial cells.
Experimental nephrology 1994;2(2):145.