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Michael Eck

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Daqi Tu; Shenghong Yang; Cai-hong Yun; Alicia Y Zhou; Zehua Zhu; David A Barbie; Edmond Chan; Gavin P Dunn; Scott B Ficarro; William C Hahn; Hyesung Jeon; Kyung-Eun Lee; Yiqun Li; Jarrod A Marto; Tran Thai; Angela V Toms; Michael J Eck
Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Daqi Tu; Wei Zheng; Bruce L Goode; Brian R Graziano; Yiqun Li; Eunyoung Park; Michael J Eck
Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.
Heidi Greulich; William C Hahn; Marcin Imielinski; Jacob D Jaffe; Bethany Kaplan; Michael S Lawrence; Se-Hoon Lee; Rachel Liao; D R Mani; Philipp Mertins; Lauren Ambrogio; Shantanu Banerji; Alice H Berger; Steven A Carr; Tzu-Hsiu Chen; Jeonghee Cho; Michael J Eck; David Frank; Gad Getz; Nam H Pho; Kumiko E Tanaka; Sarah R Walker; Wendy Winckler; Kwok-Kin Wong; Cai-Hong Yun; Jinghui Zhang; Xiaohong Zhang; Matthew Meyerson
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

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All Publications

2013: Daqi Tu; Shenghong Yang; Cai-hong Yun; Alicia Y Zhou; Zehua Zhu; David A Barbie; Edmond Chan; Gavin P Dunn; Scott B Ficarro; William C Hahn; Hyesung Jeon; Kyung-Eun Lee; Yiqun Li; Jarrod A Marto; Tran Thai; Angela V Toms; Michael J Eck
Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Cell reports 2013;3(3):747-58.
2012: Daqi Tu; Wei Zheng; Bruce L Goode; Brian R Graziano; Yiqun Li; Eunyoung Park; Michael J Eck
Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):E3424-33.
2012: Heidi Greulich; William C Hahn; Marcin Imielinski; Jacob D Jaffe; Bethany Kaplan; Michael S Lawrence; Se-Hoon Lee; Rachel Liao; D R Mani; Philipp Mertins; Lauren Ambrogio; Shantanu Banerji; Alice H Berger; Steven A Carr; Tzu-Hsiu Chen; Jeonghee Cho; Michael J Eck; David Frank; Gad Getz; Nam H Pho; Kumiko E Tanaka; Sarah R Walker; Wendy Winckler; Kwok-Kin Wong; Cai-Hong Yun; Jinghui Zhang; Xiaohong Zhang; Matthew Meyerson
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14476-81.
2012: Michael J Eck; William C Hahn
EGFR in limbo.
Cell 2012;149(4):735-7.
2012: Mai He; Pasi A Janne; Mark G Kris; Marc Ladanyi; Vincent A Miller; Khedoudja Nafa; Maria E Arcila; Marzia Capelletti; Michael J Eck; Michelle S Ginsberg; Cai-Hong Yun; Binsheng Zhao; Geoffrey R Oxnard
EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(6):1790-7.
2011: Takaaki Sasaki; Takeshi Shimamura; Magda Stumpfova; Stanislawa Weremowicz; Keith Wilner; Kwok-Kin Wong; Yun Xiao; Masahiko Yanagita; Wei Zheng; Mohit Butaney; Marzia Capelletti; James G Christensen; Jinyan Du; Michael J Eck; Dalia Ercan; Nathanael S Gray; Stephanie Heon; Jussi Koivunen; Christopher Lathan; Neal Lindeman; J Paul Marcoux; Sarah Nikiforow; Atsuko Ogino; Katsuhiro Okuda; Scott J Rodig; Pasi A Janne
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors.
Cancer research 2011;71(18):6051-60.
2011: Christina L Vizcarra; Wei Zheng; Barry Kreutz; Jun Lu; Margot E Quinlan; Avital A Rodal; Angela V Toms; Michael J Eck
Structure and function of the interacting domains of Spire and Fmn-family formins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(29):11884-9.
2011: Daqi Tu; Yiqun Li; Hyun Kyu Song; Angela V Toms; Christopher J Gould; Scott B Ficarro; Jarrod A Marto; Bruce L Goode; Michael J Eck
Crystal structure of a coiled-coil domain from human ROCK I.
PloS one 2011;6(3):e18080.
2010: Takaaki Sasaki; Katsuhiro Okuda; Wei Zheng; James E Butrynski; Marzia Capelletti; Liping Wang; Nathanael S Gray; Keith Wilner; James G Christensen; George D Demetri; Geoffrey I Shapiro; Scott J Rodig; Michael J Eck; Pasi A Janne
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers.
Cancer research 2010;70(24):10038-43.
2010: Michael J Eck; Cai-Hong Yun
Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer.
Biochimica et biophysica acta 2010;1804(3):559-66.
2010: Azin Nezami; Florence Poy; Angela Toms; Wei Zheng; Michael J Eck
Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
PloS one 2010;5(9):.
2009: Wenjun Zhou; Dalia Ercan; Liang Chen; Cai-Hong Yun; Danan Li; Marzia Capelletti; Alexis B Cortot; Lucian R Chirieac; Roxana E Iacob; Robert F Padera; John R Engen; Kwok-Kin Wong; Michael J Eck; Nathanael S Gray; Pasi A Janne
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature 2009;462(7276):1070-4.
2009: Michael J Eck; Paul W Manley
The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl.
Current opinion in cell biology 2009;21(2):288-95.
2008: Kenneth D Swanson; Yong Tang; Derek F Ceccarelli; Florence Poy; Jan P Sliwa; Benjamin G Neel; Michael J Eck
The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Molecular cell 2008;32(4):564-75.
2008: Cai-Hong Yun; Kristen E Mengwasser; Angela V Toms; Michele S Woo; Heidi Greulich; Kwok-Kin Wong; Matthew Meyerson; Michael J Eck
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2070-5.
2008: Daniel Lietha; Michael J Eck
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.
PloS one 2008;3(11):e3800.
2008: Xinming Cai; Daniel Lietha; Derek F J Ceccarelli; Andrei Karginov; Zenon Rajfur; Ken Jacobson; Klaus M Hahn; Michael J Eck; Michael D Schaller
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
Molecular and cellular biology 2008;28(1):201-14.
2007: Danan Li; Takeshi Shimamura; Hongbin Ji; Liang Chen; Henry J Haringsma; Kate McNamara; Mei-Chih Liang; Samanthi A Perera; Sara Zaghlul; Christa L Borgman; Shigeto Kubo; Masaya Takahashi; Yanping Sun; Lucian R Chirieac; Robert F Padera; Neal Lindeman; Pasi A Janne; Roman K Thomas; Matthew Meyerson; Michael J Eck; Jeffrey A Engelman; Geoffrey I Shapiro; Kwok-Kin Wong
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Cancer cell 2007;12(1):81-93.
2007: Jun Lu; Wuyi Meng; Florence Poy; Sankar Maiti; Bruce L Goode; Michael J Eck
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly.
Journal of molecular biology 2007;369(5):1258-69.
2007: Daniel Lietha; Xinming Cai; Derek F J Ceccarelli; Yiqun Li; Michael D Schaller; Michael J Eck
Structural basis for the autoinhibition of focal adhesion kinase.
Cell 2007;129(6):1177-87.
2007: Jimmy A Blair; Daniel Rauh; Charles Kung; Cai-Hong Yun; Qi-Wen Fan; Haridas Rode; Chao Zhang; Michael J Eck; William A Weiss; Kevan M Shokat
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Nature chemical biology 2007;3(4):229-38.
2007: Cai-Hong Yun; Titus Boggon; Yiqun Li; Michele S Woo; Heidi Greulich; Matthew Meyerson; Michael J Eck
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
Cancer cell 2007;11(3):217-27.
2007: Bruce L Goode; Michael J Eck
Mechanism and function of formins in the control of actin assembly.
Annual review of biochemistry 2007;76():593-627.
2006: Hongbin Ji; Xiaojun Zhao; Yuki Yuza; Takeshi Shimamura; Danan Li; Alexei Protopopov; Boonim L Jung; Kate McNamara; Huili Xia; Karen A Glatt; Roman K Thomas; Hidefumi Sasaki; James W Horner; Michael J Eck; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Roderick T Bronson; Sridhar K Rabindran; Carolyn Discafani; Elizabeth Maher; Geoffrey I Shapiro; Matthew Meyerson; Kwok-Kin Wong
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7817-22.
2006: Azin G Nezami; Florence Poy; Michael J Eck
Structure of the autoinhibitory switch in formin mDia1.
Structure (London, England : 1993) 2006;14(2):257-63.
2006: Derek F J Ceccarelli; Hyun Kyu Song; Florence Poy; Michael D Schaller; Michael J Eck
Crystal structure of the FERM domain of focal adhesion kinase.
The Journal of biological chemistry 2006;281(1):252-9.
2005: Titus Boggon; Yiqun Li; Paul W Manley; Michael J Eck
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.
Blood 2005;106(3):996-1002.
2005: Ross Levine; Martha Wadleigh; Jan Cools; Benjamin L Ebert; Gerlinde Wernig; Brian J P Huntly; Titus Boggon; Iwona Wlodarska; Jennifer J Clark; Sandra Moore; Jennifer Adelsperger; Sumin Koo; Jeffrey C Lee; Stacey Gabriel; Thomas Mercher; Alan D D'Andrea; Stefan Fröhling; Konstanze Döhner; Peter Marynen; Peter Vandenberghe; Ruben A Mesa; Ayalew Tefferi; James D Griffin; Michael J Eck; William R Sellers; Matthew Meyerson; Todd R Golub; Stephanie J Lee; D Gary Gilliland
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Cancer cell 2005;7(4):387-97.
2005: Susumu Kobayashi; Titus Boggon; Tajhal Dayaram; Pasi A Janne; Olivier Kocher; Matthew Meyerson; Bruce E Johnson; Michael J Eck; Daniel G Tenen; Balazs Halmos
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.
The New England journal of medicine 2005;352(8):786-92.
2004: Titus Boggon; Michael J Eck
Structure and regulation of Src family kinases.
Oncogene 2004;23(48):7918-27.
2004: Jingrui Jiang; J Guillermo Paez; Jeffrey C Lee; Ronghai Bo; Richard M Stone; Daniel J DeAngelo; Ilene Galinsky; Brian M Wolpin; Anna Jonasova; Paula Herman; Edward A Fox; Titus Boggon; Michael J Eck; Ellen Weisberg; James D Griffin; D Gary Gilliland; Matthew Meyerson; William R Sellers
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Blood 2004;104(6):1855-8.
2004: Andrew L Kung; Sonya D Zabludoff; Dennis Stanley France; Steven J Freedman; Elizabeth A Tanner; Annelisa Vieira; Susan Cornell-Kennon; Jennifer Lee; Beqing Wang; Jamin Wang; Klaus Memmert; Hans-Ulrich Naegeli; Frank Petersen; Michael J Eck; Kenneth W Bair; Alexander W Wood; David M Livingston
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Cancer cell 2004;6(1):33-43.
2004: J Guillermo Paez; Pasi A Janne; Jeffrey C Lee; Sean Tracy; Heidi Greulich; Stacey Gabriel; Paula Herman; Frederic J Kaye; Neal Lindeman; Titus Boggon; Katsuhiko Naoki; Hidefumi Sasaki; Yoshitaka Fujii; Michael J Eck; William R Sellers; Bruce E Johnson; Matthew Meyerson
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
Science (New York, N.Y.) 2004;304(5676):1497-500.
2004: Jill M Dunty; Veronica Gabarra-Niecko; Michelle L King; Derek F J Ceccarelli; Michael J Eck; Michael D Schaller
FERM domain interaction promotes FAK signaling.
Molecular and cellular biology 2004;24(12):5353-68.
2004: Maria Simarro; Arpad Lanyi; Duncan Howie; Florence Poy; Joost Bruggeman; Michelle Choi; Janos Sumegi; Michael J Eck; Cox Terhorst
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.
International immunology 2004;16(5):727-36.
2004: Yingwu Xu; James Moseley; Isabelle Sagot; Florence Poy; David Pellman; Bruce L Goode; Michael J Eck
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.
Cell 2004;116(5):711-23.
2004: James Moseley; Isabelle Sagot; Amity L Manning; Yingwu Xu; Michael J Eck; David Pellman; Bruce L Goode
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin.
Molecular biology of the cell 2004;15(2):896-907.
2003: Harry Towbin; Kenneth W Bair; James A DeCaprio; Michael J Eck; Sunkyu Kim; Frederick R Kinder; Anthony Morollo; Dieter R Mueller; Patrick Schindler; Hyun Kyu Song; Jan Van Oostrum; Richard W Versace; Hans Voshol; Jeanette Wood; Sonya Zabludoff; Penny E Phillips
Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.
The Journal of biological chemistry 2003;278(52):52964-71.
2003: Pablo Engel; Michael J Eck; Cox Terhorst
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.
Nature reviews. Immunology 2003;3(10):813-21.
2003: Peter W Kim; Zhen-Yu J Sun; Stephen C Blacklow; Gerhard Wagner; Michael J Eck
A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science (New York, N.Y.) 2003;301(5640):1725-8.
2003: Hyun Kyu Song; Michael J Eck
Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine.
Molecular cell 2003;12(1):75-86.
2003: Steven J Freedman; Zhen-Yu J Sun; Andrew L Kung; Dennis Stanley France; Gerhard Wagner; Michael J Eck
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
Nature structural biology 2003;10(7):504-12.
2003: Jia-huai Wang; Michael J Eck
Assembling atomic resolution views of the immunological synapse.
Current opinion in immunology 2003;15(3):286-93.
2003: Peggy C Stolt; Hyesung Jeon; Hyun Kyu Song; Joachim Herz; Michael J Eck; Stephen C Blacklow
Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes.
Structure (London, England : 1993) 2003;11(5):569-79.
2003: Steven J Freedman; Hyun Kyu Song; Yingwu Xu; Zhen-Yu J Sun; Michael J Eck
Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain.
The Journal of biological chemistry 2003;278(15):13462-7.
2003: Betty Chan; Arpad Lanyi; Hyun Kyu Song; Jan Griesbach; Maria Simarro-Grande; Florence Poy; Duncan Howie; Janos Sumegi; Cox Terhorst; Michael J Eck
SAP couples Fyn to SLAM immune receptors.
Nature cell biology 2003;5(2):155-60.
2003: Justin M Summy; Marius Sudol; Michael J Eck; Alvaro Monteiro; Amanda Gatesman; Daniel C Flynn
Specificity in signaling by c-Yes.
Frontiers in bioscience : a journal and virtual library 2003;8():s185-205.
2002: Steven J Freedman; Zhen-Yu J Sun; Florence Poy; Andrew L Kung; David M Livingston; Gerhard Wagner; Michael J Eck
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5367-72.
2002: Laurie A Witucki; Xin Huang; Kavita Shah; Yi Liu; Saw Kyin; Michael J Eck; Kevan M Shokat
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chemistry & biology 2002;9(1):25-33.
2001: Florence Poy; Maina Lepourcelet; Ramesh A Shivdasani; Michael J Eck
Structure of a human Tcf4-beta-catenin complex.
Nature structural biology 2001;8(12):1053-7.
2001: Massimo Morra; J Lu; Florence Poy; M Martin; Joan Sayos; Silvia Calpe; Charles Gullo; Duncan Howie; svend rietdijk; A Thompson; Anthony J Coyle; C Denny; M B Yaffe; Pablo Engel; Michael J Eck; Cox Terhorst
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
The EMBO journal 2001;20(21):5840-52.
2001: Massimo Morra; M Simarro-Grande; M Martin; A S Chen; Arpad Lanyi; O Silander; Silvia Calpe; J Davis; T Pawson; Michael J Eck; Janos Sumegi; Pablo Engel; S C Li; Cox Terhorst
Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.
The Journal of biological chemistry 2001;276(39):36809-16.
2001: Hyesung Jeon; W Meng; Junichi Takagi; Michael J Eck; Timothy A Springer; Stephen C Blacklow
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nature structural biology 2001;8(6):499-504.
2001: A A Morollo; Michael J Eck
Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium.
Nature structural biology 2001;8(3):243-7.
2000: Ming Lei; W Lu; W Meng; Maria Carla Parrini; Michael J Eck; Bruce J Mayer; Stephen C Harrison
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell 2000;102(3):387-97.
2000: X Huang; Florence Poy; R Zhang; Andrzej Joachimiak; Marius Sudol; Michael J Eck
Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan.
Nature structural biology 2000;7(8):634-8.
2000: Sansana Sawasdikosol; JC Pratt; W Meng; Michael J Eck; Steven J Burakoff
Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase.
Biochimica et biophysica acta 2000;1471(1):M1-M12.
1999: Florence Poy; M B Yaffe; Joan Sayos; K Saxena; Massimo Morra; Janos Sumegi; Lewis C Cantley; Cox Terhorst; Michael J Eck
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Molecular cell 1999;4(4):555-61.
1999: ML Lupher; Navin Rao; Michael J Eck; Hamid Band
The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction.
Immunology today 1999;20(8):375-82.
1999: Sirano Dhe-Paganon; EA Ottinger; R T Nolte; Michael J Eck; Steven E Shoelson
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8378-83.
1999: W Xu; Amish Doshi; Ming Lei; Michael J Eck; Stephen C Harrison
Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Molecular cell 1999;3(5):629-38.
1999: W Meng; Sansana Sawasdikosol; Steven J Burakoff; Michael J Eck
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature 1999;398(6722):84-90.
1998: Morgan Huse; Michael J Eck; Stephen C Harrison
A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck.
The Journal of biological chemistry 1998;273(30):18729-33.
1998: P Hof; S Pluskey; Sirano Dhe-Paganon; Michael J Eck; Steven E Shoelson
Crystal structure of the tyrosine phosphatase SHP-2.
Cell 1998;92(4):441-50.
1998: D Sondhi; W Xu; Zhou Songyang; Michael J Eck; Philip A Cole
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.
Biochemistry 1998;37(1):165-72.
1997: W Xu; Stephen C Harrison; Michael J Eck
Three-dimensional structure of the tyrosine kinase c-Src.
Nature 1997;385(6617):595-602.
1996: Kapil Saxena; C Gaitatzes; M T Walsh; Michael J Eck; Eva J Neer; Temple F Smith
Analysis of the physical properties and molecular modeling of Sec13: A WD repeat protein involved in vesicular traffic.
Biochemistry 1996;35(48):15215-21.
1996: Winfried Weissenhorn; Michael J Eck; S C Harrison; Don C Wiley
Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro.
European journal of biochemistry / FEBS 1996;238(2):440-5.
1996: Michael J Eck; Sirano Dhe-Paganon; T Trüb; R T Nolte; Steven E Shoelson
Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor.
Cell 1996;85(5):695-705.
1996: R T Nolte; Michael J Eck; J Schlessinger; Steven E Shoelson; S C Harrison
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
Nature structural biology 1996;3(4):364-74.
1996: Michael J Eck; S Pluskey; T Trüb; S C Harrison; Steven E Shoelson
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2.
Nature 1996;379(6562):277-80.
1995: Michael J Eck
A new flavor in phosphotyrosine recognition.
Structure (London, England : 1993) 1995;3(5):421-4.
1995: Bruce J Mayer; Michael J Eck
SH3 domains. Minding your p's and q's.
Current biology : CB 1995;5(4):364-7.
1995: Zhou Songyang; Kermit L Carraway; Michael J Eck; S C Harrison; Ricardo A Feldman; Moosa Mohammadi; Joseph Schlessinger; Stevan Hubbard; D P Smith; Charis Eng
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
Nature 1995;373(6514):536-9.
1994: L E Rodseth; B Brandhuber; T Q Devine; Michael J Eck; K Hale; James H Naismith; Stephen R Sprang
Two crystal forms of the extracellular domain of type I tumor necrosis factor receptor.
Journal of molecular biology 1994;239(2):332-5.
1994: Michael J Eck; S K Atwell; S E Shoelson; S C Harrison
Structure of the regulatory domains of the Src-family tyrosine kinase Lck.
Nature 1994;368(6473):764-9.
1993: Michael J Eck; Steven E Shoelson; S C Harrison
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
Nature 1993;362(6415):87-91.
1992: Michael J Eck; Mark Ultsch; E Rinderknecht; Abraham M de Vos; Stephen R Sprang
The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.
The Journal of biological chemistry 1992;267(4):2119-22.
1989: Michael J Eck; Stephen R Sprang
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
The Journal of biological chemistry 1989;264(29):17595-605.
1988: Michael J Eck; Bruce Beutler; G Kuo; J P Merryweather; Stephen R Sprang
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).
The Journal of biological chemistry 1988;263(26):12816-9.