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Kenneth Eckels

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Wellington Sun; Stephen J Thomas; David W Vaughn; Kenneth H Eckels; Stefan Fernandez; Robert V Gibbons; Vicky J Gunther; Arthur G Lyons; Mammen P Mammen; J Robert Putnak; John D Statler; Bruce L Innis
Experimental dengue virus challenge of human subjects previously vaccinated with live attenuated tetravalent dengue vaccines.
Stephen J Thomas; Jean-Francois Toussaint; Robert Putnak; Wellington Sun; Kristen Bauer; Isabelle Carletti; Rafael De La Barrera; Francis Dessy; Kenneth H Eckels; Stefan Fernandez; Robert V Gibbons; Bruce L Innis
A phase II, randomized, safety and immunogenicity study of a re-derived, live-attenuated dengue virus vaccine in healthy adults.
Veerachai Watanaveeradej; Ananda Nisalak; J Robert Putnak; Rudiwilai Samakoses; Sriluck Simasathien; Stephen J Thomas; David W Vaughn; Rafael De La Barrera; Kenneth H Eckels; Timothy Endy; Robert V Gibbons; Sumetha Hengprasert; Bruce L Innis; Rick G Jarman; Angkool Kerdpanich; Mammen P Mammen
Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus-naive infants.

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All Publications

2013: Wellington Sun; Stephen J Thomas; David W Vaughn; Kenneth H Eckels; Stefan Fernandez; Robert V Gibbons; Vicky J Gunther; Arthur G Lyons; Mammen P Mammen; J Robert Putnak; John D Statler; Bruce L Innis
Experimental dengue virus challenge of human subjects previously vaccinated with live attenuated tetravalent dengue vaccines.
The Journal of infectious diseases 2013;207(5):700-8.
2013: Stephen J Thomas; Jean-Francois Toussaint; Robert Putnak; Wellington Sun; Kristen Bauer; Isabelle Carletti; Rafael De La Barrera; Francis Dessy; Kenneth H Eckels; Stefan Fernandez; Robert V Gibbons; Bruce L Innis
A phase II, randomized, safety and immunogenicity study of a re-derived, live-attenuated dengue virus vaccine in healthy adults.
The American journal of tropical medicine and hygiene 2013;88(1):73-88.
2011: Veerachai Watanaveeradej; Ananda Nisalak; J Robert Putnak; Rudiwilai Samakoses; Sriluck Simasathien; Stephen J Thomas; David W Vaughn; Rafael De La Barrera; Kenneth H Eckels; Timothy Endy; Robert V Gibbons; Sumetha Hengprasert; Bruce L Innis; Rick G Jarman; Angkool Kerdpanich; Mammen P Mammen
Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus-naive infants.
The American journal of tropical medicine and hygiene 2011;85(2):341-51.
2011: Kathryn B Anderson; Kenneth H Eckels; Robert Edelman; Robert V Gibbons; Bruce L Innis; Robert Putnak; Wellington Sun
Interference and facilitation between dengue serotypes in a tetravalent live dengue virus vaccine candidate.
The Journal of infectious diseases 2011;204(3):442-50.
2011: V J Gunther; Robert Putnak; Kenneth H Eckels; Mammen P Mammen; J M Scherer; A Lyons; Marcelo B Sztein; Wellington Sun
A human challenge model for dengue infection reveals a possible protective role for sustained interferon gamma levels during the acute phase of illness.
Vaccine 2011;29(22):3895-904.
2009: Germán Añez; Ruhe Men; Kenneth H Eckels; Ching-Juh Lai
Passage of dengue virus type 4 vaccine candidates in fetal rhesus lung cells selects heparin-sensitive variants that result in loss of infectivity and immunogenicity in rhesus macaques.
Journal of virology 2009;83(20):10384-94.
2009: Wellington Sun; Dennis Cunningham; Steven Wasserman; Judith Perry; J Robert Putnak; Kenneth H Eckels; David W Vaughn; Stephen J Thomas; Niranjan Kanesa-Thasan; Bruce L Innis; Robert Edelman
Phase 2 clinical trial of three formulations of tetravalent live-attenuated dengue vaccine in flavivirus-naïve adults.
Human vaccines 2009;5(1):33-40.
2008: J Robert Putnak; Rafael de la Barrera; Timothy Burgess; Jorge Pardo; Francis Dessy; Dirk Gheysen; Yves LOBET; Sharone Green; Timothy Endy; Stephen J Thomas; Kenneth H Eckels; Bruce L Innis; Wellington Sun
Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies.
The American journal of tropical medicine and hygiene 2008;79(1):115-22.
2008: Sriluck Simasathien; Stephen J Thomas; Veerachai Watanaveeradej; Ananda Nisalak; Célia Barberousse; Bruce L Innis; Wellington Sun; J Robert Putnak; Kenneth H Eckels; Yanee Hutagalung; Robert V Gibbons; Chunlin Zhang; Rafael De La Barrera; Rick G Jarman; Wipa Chawachalasai; Mammen P Mammen
Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus naive children.
The American journal of tropical medicine and hygiene 2008;78(3):426-33.
2007: Arthur Lyons; Niranjan Kanesa-Thasan; Robert A Kuschner; Kenneth H Eckels; Robert Putnak; Wellington Sun; Robert Burge; Andrew C Towle; Paul Wilson; Erich Tauber; David W Vaughn
A Phase 2 study of a purified, inactivated virus vaccine to prevent Japanese encephalitis.
Vaccine 2007;25(17):3445-53.
2006: Wellington Sun; Ananda Nisalak; Montip Gettayacamin; Kenneth H Eckels; J Robert Putnak; David W Vaughn; Bruce L Innis; Stephen J Thomas; Timothy Endy
Protection of Rhesus monkeys against dengue virus challenge after tetravalent live attenuated dengue virus vaccination.
The Journal of infectious diseases 2006;193(12):1658-65.
2005: J Robert Putnak; Beth-Ann Coller; Gerald Voss; David W Vaughn; David Clements; Iain Peters; Gary Bignami; Huo-Shu H Houng; Robert C-M Chen; Dave Barvir; Jitvimol Seriwatana; Sylvie Cayphas; Nathalie Garçon; Dirk Gheysen; Niranjan Kanesa-Thasan; Mike McDonell; Tom Humphreys; Kenneth H Eckels; jean-paul prieels; Bruce L Innis
An evaluation of dengue type-2 inactivated, recombinant subunit, and live-attenuated vaccine candidates in the rhesus macaque model.
Vaccine 2005;23(35):4442-52.
2003: Bruce L Innis; Kenneth H Eckels
Progress in development of a live-attenuated, tetravalent dengue virus vaccine by the United States Army Medical Research and Materiel Command.
The American journal of tropical medicine and hygiene 2003;69(6 Suppl):1-4.
2003: Robert Edelman; Steven Wasserman; Sacared A Bodison; Robert Putnak; Kenneth H Eckels; Douglas Tang; Niranjan Kanesa-Thasan; David W Vaughn; Bruce L Innis; Wellington Sun
Phase I trial of 16 formulations of a tetravalent live-attenuated dengue vaccine.
The American journal of tropical medicine and hygiene 2003;69(6 Suppl):48-60.
2003: Wellington Sun; Robert Edelman; Niranjan Kanesa-Thasan; Kenneth H Eckels; J Robert Putnak; Alan D King; Huo-Shu H Houng; Douglas Tang; John M Scherer; Charles Hoke; Bruce L Innis
Vaccination of human volunteers with monovalent and tetravalent live-attenuated dengue vaccine candidates.
The American journal of tropical medicine and hygiene 2003;69(6 Suppl):24-31.
2003: Niranjan Kanesa-Thasan; Robert Edelman; Carol O Tacket; Steven Wasserman; David W Vaughn; T S Coster; G J Kim-Ahn; Doria R Dubois; J Robert Putnak; A King; P L Summers; Bruce L Innis; Kenneth H Eckels; Charles Hoke
Phase 1 studies of Walter Reed Army Institute of Research candidate attenuated dengue vaccines: selection of safe and immunogenic monovalent vaccines.
The American journal of tropical medicine and hygiene 2003;69(6 Suppl):17-23.
2003: Kenneth H Eckels; Doria R Dubois; Robert Putnak; David W Vaughn; Bruce L Innis; Erik A Henchal; Charles Hoke
Modification of dengue virus strains by passage in primary dog kidney cells: preparation of candidate vaccines and immunization of monkeys.
The American journal of tropical medicine and hygiene 2003;69(6 Suppl):12-6.
2003: Kenneth H Eckels; Robert Putnak
Formalin-inactivated whole virus and recombinant subunit flavivirus vaccines.
Advances in virus research 2003;61():395-418.
2001: S P Hong; W D Yoo; Robert Putnak; Kenneth H Eckels; H M Rho; S O Kim
Nucleotide sequence of envelope protein of Japanese encephalitis virus SA14-14-2 adapted to vero cells.
DNA sequence : the journal of DNA sequencing and mapping 2001;12(5-6):437-42.
2001: A K Srivastava; J Robert Putnak; S H Lee; S P Hong; S B Moon; Dave Barvir; B Zhao; R A Olson; S O Kim; W D Yoo; A C Towle; David W Vaughn; Bruce L Innis; Kenneth H Eckels
A purified inactivated Japanese encephalitis virus vaccine made in Vero cells.
Vaccine 2001;19(31):4557-65.
1998: Monika Simmons; Kevin R Porter; J Escamilla; R Graham; Douglas M Watts; Kenneth H Eckels; Curtis G Hayes
Evaluation of recombinant dengue viral envelope B domain protein antigens for the detection of dengue complex-specific antibodies.
The American journal of tropical medicine and hygiene 1998;58(2):144-51.
1997: B Puri; William Nelson; Erik A Henchal; Charles Hoke; Kenneth H Eckels; Doria R Dubois; Kevin R Porter; Curtis G Hayes
Molecular analysis of dengue virus attenuation after serial passage in primary dog kidney cells.
The Journal of general virology 1997;78 ( Pt 9)():2287-91.
1996: R Putnak; D A Barvir; J M Burrous; D R Dubois; V M D'Andrea; Charles Hoke; J C Sadoff; Kenneth H Eckels
Development of a purified, inactivated, dengue-2 virus vaccine prototype in Vero cells: immunogenicity and protection in mice and rhesus monkeys.
The Journal of infectious diseases 1996;174(6):1176-84.
1995: Ichiro Kurane; Bruce L Innis; Charles Hoke; Kenneth H Eckels; A Meager; J Janus; Irene Bosch
T cell activation in vivo by dengue virus infection.
Journal of clinical & laboratory immunology 1995;46(1):35-40.
1994: Robert Edelman; Carol O Tacket; Steven Wasserman; David W Vaughn; Kenneth H Eckels; D R Dubois; P L Summers; Charles Hoke
A live attenuated dengue-1 vaccine candidate (45AZ5) passaged in primary dog kidney cell culture is attenuated and immunogenic for humans.
The Journal of infectious diseases 1994;170(6):1448-55.
1994: Philip A Mackowiak; Steven Wasserman; Carol O Tacket; David W Vaughn; Kenneth H Eckels; D R Dubois; Charles Hoke; Robert Edelman
Quantitative relationship between oral temperature and severity of illness following inoculation with candidate attenuated dengue virus vaccines.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1994;19(5):948-50.
1994: Kenneth H Eckels; D R Dubois; P L Summers; J J Schlesinger; M Shelly; S Cohen; Y M Zhang; Ching-Juh Lai; I Kurane; A Rothman
Immunization of monkeys with baculovirus-dengue type-4 recombinants containing envelope and nonstructural proteins: evidence of priming and partial protection.
The American journal of tropical medicine and hygiene 1994;50(4):472-8.
1993: Sharone Green; Ichiro Kurane; Robert Edelman; Carol O Tacket; Kenneth H Eckels; David W Vaughn; Charles Hoke; Irene Bosch
Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination.
Journal of virology 1993;67(10):5962-7.
1993: P L Summers; D R Dubois; W H Cohen; P O Macarthy; Leonard N Binn; M H Sjogren; R Snitbhan; Bruce L Innis; Kenneth H Eckels
Solid-phase antibody capture hemadsorption assay for detection of hepatitis A virus immunoglobulin M antibodies.
Journal of clinical microbiology 1993;31(5):1299-302.
1992: Charles Hoke; Leonard N Binn; J E Egan; RF DeFraites; P O MacArthy; Bruce L Innis; Kenneth H Eckels; D Dubois; E D'Hondt; M H Sjogren
Hepatitis A in the US Army: epidemiology and vaccine development.
Vaccine 1992;10 Suppl 1():S75-9.
1992: J J Schlesinger; J R Putnak; Kenneth H Eckels
New approaches to flavivirus vaccine development.
Biotechnology (Reading, Mass.) 1992;20():289-307.
1991: Antoinette B Hartman; C J Powell; C L Schultz; Edwin V Oaks; Kenneth H Eckels
Small-animal model to measure efficacy and immunogenicity of Shigella vaccine strains.
Infection and immunity 1991;59(11):4075-83.
1991: D R Dubois; Kenneth H Eckels; John Ticehurst; Leonard N Binn; R L Timchak; D A Barvir; C T Rankin; S P O'Neill
Large-scale purification of inactivated hepatitis A virus by centrifugation in non-ionic gradients.
Journal of virological methods 1991;32(2-3):327-34.
1991: M H Sjogren; Charles Hoke; Leonard N Binn; Kenneth H Eckels; D R Dubois; L Lyde; A Tsuchida; S Oaks; R Marchwicki; W Lednar
Immunogenicity of an inactivated hepatitis A vaccine.
Annals of internal medicine 1991;114(6):470-1.
1990: S Cohen; C J Powell; D R Dubois; A Hartman; P L Summers; Kenneth H Eckels
Expression of the envelope antigen of dengue virus in vaccine strains of Salmonella.
Research in microbiology 1990;141(7-8):855-8.
1990: Charles Hoke; Frank J Malinoski; Kenneth H Eckels; R M Scott; D R Dubois; P L Summers; T Simms; J Burrous; S E Hasty; W H Bancroft
Preparation of an attenuated dengue 4 (341750 Carib) virus vaccine. II. Safety and immunogenicity in humans.
The American journal of tropical medicine and hygiene 1990;43(2):219-26.
1990: N J Marchette; D R Dubois; L K Larsen; P L Summers; E G Kraiselburd; D J Gubler; Kenneth H Eckels
Preparation of an attenuated dengue 4 (341750 Carib) virus vaccine. I. Pre-clinical studies.
The American journal of tropical medicine and hygiene 1990;43(2):212-8.
1990: D R Dubois; Leonard N Binn; P L Summers; R L Timchak; D A Barvir; R H Marchwicki; Kenneth H Eckels
Preparation of noninfectious hepatitis A virus hemagglutinin for detecting hemagglutination inhibition antibodies.
Journal of virological methods 1990;28(3):299-304.
1989: B M Kaufman; P L Summers; D R Dubois; W H Cohen; M K Gentry; R L Timchak; Donald S. Burke; Kenneth H Eckels
Monoclonal antibodies for dengue virus prM glycoprotein protect mice against lethal dengue infection.
The American journal of tropical medicine and hygiene 1989;41(5):576-80.
1989: Mike Bray; B T Zhao; L Markoff; Kenneth H Eckels; Robert M Chanock; Ching-Juh Lai
Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.
Journal of virology 1989;63(6):2853-6.
1989: Kenneth H Eckels; P L Summers; D R Dubois
Hepatitis A virus hemagglutination and a test for hemagglutination inhibition antibodies.
Journal of clinical microbiology 1989;27(6):1375-6.
1989: P L Summers; W H Cohen; M M Ruiz; T Hase; Kenneth H Eckels
Flaviviruses can mediate fusion from without in Aedes albopictus mosquito cell cultures.
Virus research 1989;12(4):383-92.
1989: T Hase; P L Summers; Kenneth H Eckels
Flavivirus entry into cultured mosquito cells and human peripheral blood monocytes.
Archives of virology 1989;104(1-2):129-43.
1989: T Hase; P L Summers; Kenneth H Eckels; J R Putnak
Morphogenesis of flaviviruses.
Sub-cellular biochemistry 1989;15():275-305.
1988: Kenneth H Eckels; Y X Yu; D R Dubois; N J Marchette; D W Trent; A J Johnson
Japanese encephalitis virus live-attenuated vaccine, Chinese strain SA14-14-2; adaptation to primary canine kidney cell cultures and preparation of a vaccine for human use.
Vaccine 1988;6(6):513-8.
1988: Bruce L Innis; Kenneth H Eckels; E Kraiselburd; D R Dubois; G F Meadors; D J Gubler; Donald S. Burke; W H Bancroft
Virulence of a live dengue virus vaccine candidate: a possible new marker of dengue virus attenuation.
The Journal of infectious diseases 1988;158(4):876-80.
1988: Y M Zhang; E P Hayes; T C McCarty; D R Dubois; P L Summers; Kenneth H Eckels; Robert M Chanock; Ching-Juh Lai
Immunization of mice with dengue structural proteins and nonstructural protein NS1 expressed by baculovirus recombinant induces resistance to dengue virus encephalitis.
Journal of virology 1988;62(8):3027-31.
1987: B T Zhao; G Prince; R Horswood; Kenneth H Eckels; P Summers; Robert M Chanock; Ching-Juh Lai
Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus.
Journal of virology 1987;61(12):4019-22.
1987: K T McKee; W H Bancroft; Kenneth H Eckels; Robert R Redfield; P L Summers; P K Russell
Lack of attenuation of a candidate dengue 1 vaccine (45AZ5) in human volunteers.
The American journal of tropical medicine and hygiene 1987;36(2):435-42.
1987: B M Kaufman; P L Summers; D R Dubois; Kenneth H Eckels
Monoclonal antibodies against dengue 2 virus E-glycoprotein protect mice against lethal dengue infection.
The American journal of tropical medicine and hygiene 1987;36(2):427-34.
1987: T Hase; P L Summers; Kenneth H Eckels; W B Baze
An electron and immunoelectron microscopic study of dengue-2 virus infection of cultured mosquito cells: maturation events.
Archives of virology 1987;92(3-4):273-91.
1987: T Hase; P L Summers; Kenneth H Eckels; W B Baze
Maturation process of Japanese encephalitis virus in cultured mosquito cells in vitro and mouse brain cells in vivo.
Archives of virology 1987;96(3-4):135-51.
1985: Kenneth H Eckels; S C Kliks; D R Dubois; L M Wahl; W H Bancroft
The association of enhancing antibodies with seroconversion in humans receiving a dengue-2 live-virus vaccine.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(6):4201-3.
1984: R M Scott; A L Shelton; Kenneth H Eckels; W H Bancroft; R J Summers; P K Russell
Human hypersensitivity to a sham vaccine prepared from mosquito-cell culture fluids.
The Journal of allergy and clinical immunology 1984;74(6):808-11.
1984: Kenneth H Eckels; R M Scott; W H Bancroft; J Brown; D R Dubois; P L Summers; P K Russell; S B Halstead
Selection of attenuated dengue 4 viruses by serial passage in primary kidney cells. V. Human response to immunization with a candidate vaccine prepared in fetal rhesus lung cells.
The American journal of tropical medicine and hygiene 1984;33(4):684-9.
1984: S B Halstead; Kenneth H Eckels; R Putvatana; L K Larsen; N J Marchette
Selection of attenuated dengue 4 viruses by serial passage in primary kidney cells. IV. Characterization of a vaccine candidate in fetal rhesus lung cells.
The American journal of tropical medicine and hygiene 1984;33(4):679-83.
1984: W H Bancroft; R M Scott; Kenneth H Eckels; Charles Hoke; T E Simms; K D Jesrani; P L Summers; D R Dubois; D Tsoulos; P K Russell
Dengue virus type 2 vaccine: reactogenicity and immunogenicity in soldiers.
The Journal of infectious diseases 1984;149(6):1005-10.
1984: P L Summers; Kenneth H Eckels; J M Dalrymple; R M Scott; V A Boyd
Antibody response to dengue-2 vaccine measured by two different radioimmunoassay methods.
Journal of clinical microbiology 1984;19(5):651-9.
1983: R M Scott; Kenneth H Eckels; W H Bancroft; P L Summers; J M McCown; J H Anderson; P K Russell
Dengue 2 vaccine: dose response in volunteers in relation to yellow fever immune status.
The Journal of infectious diseases 1983;148(6):1055-60.
1983: Kenneth H Eckels; P L Summers; P K Russell
Temperature-sensitive events during the replication of the attenuated S-1 clone of dengue type 2 virus.
Infection and immunity 1983;39(2):750-4.
1982: Barry R Miller; B J Beaty; T H Aitken; Kenneth H Eckels; P K Russell
Dengue-2 vaccine: oral infection, transmission, and lack of evidence for reversion in the mosquito, Aedes aegypti.
The American journal of tropical medicine and hygiene 1982;31(6):1232-7.
1982: W H Bancroft; R M Scott; W E Brandt; J M McCown; Kenneth H Eckels; D E Hayes; D J Gould; P K Russell
Dengue-2 vaccine: infection of Aedes aegypti mosquitoes by feeding on viremic recipients.
The American journal of tropical medicine and hygiene 1982;31(6):1229-31.
1981: W H Bancroft; Franklin H Jr Top; Kenneth H Eckels; J H Anderson; J M McCown; P K Russell
Dengue-2 vaccine: virological, immunological, and clinical responses of six yellow fever-immune recipients.
Infection and immunity 1981;31(2):698-703.
1980: R M Scott; A Nisalak; Kenneth H Eckels; M Tingpalapong; V R Harrison; D J Gould; F E Chapple; P K Russell
Dengue-2 vaccine: viremia and immune responses in rhesus monkeys.
Infection and immunity 1980;27(1):181-6.
1980: Kenneth H Eckels; V R Harrison; P L Summers; P K Russell
Dengue-2 vaccine: preparation from a small-plaque virus clone.
Infection and immunity 1980;27(1):175-80.