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Elizabeth Eckman

Research Profile

Chemicals & Drugs

Disorders

Alzheimer's Disease

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Anatomy

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Enzyme-Linked Immunosorbent Assay

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Publications

TOP 3
Javier Pacheco-Quinto; Elizabeth A Eckman
Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.
Javier Pacheco-Quinto; Aimee Herdt; Christopher B Eckman; Elizabeth A Eckman
Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease.
Jaehong Suh; Lirong Wang; Elizabeth A Eckman; Alvin Lyckman; Suzanne Y Guénette
FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing.

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All Publications

2013: Javier Pacheco-Quinto; Elizabeth A Eckman
Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.
The Journal of biological chemistry 2013;288(8):5606-15.
2013: Javier Pacheco-Quinto; Aimee Herdt; Christopher B Eckman; Elizabeth A Eckman
Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S101-10.
2011: Jaehong Suh; Lirong Wang; Elizabeth A Eckman; Alvin Lyckman; Suzanne Y Guénette
FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing.
Journal of neurochemistry 2011;119(2):377-88.
2009: Amanda Hanna; P Horne; Debra Yager; Christopher B Eckman; Elizabeth A Eckman; Christopher Janus
Amyloid beta and impairment in multiple memory systems in older transgenic APP TgCRND8 mice.
Genes, brain, and behavior 2009;8(7):676-84.
2007: Christopher B Eckman; Elizabeth A Eckman
An update on the amyloid hypothesis.
Neurologic clinics 2007;25(3):669-82, vi.
2007: Edward T Parkin; Nicole T Watt; Ishrut Hussain; Elizabeth A Eckman; Christopher B Eckman; Jean C Manson; Herbert N Baybutt; Anthony J Turner; Nigel M Hooper
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):11062-7.
2006: Elizabeth A Eckman; Stephanie K Adams; Frederick J Troendle; Becky A Stodola; Murad A Kahn; Abdul Fauq; Hong D Xiao; Kenneth E Bernstein; Christopher B Eckman
Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.
The Journal of biological chemistry 2006;281(41):30471-8.
2006: Feng Chen; Elizabeth A Eckman; Christopher B Eckman
Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1269-71.
2006: Suzanne Y Guénette; Yang Chang; Thomas Hiesberger; James A Richardson; Christopher B Eckman; Elizabeth A Eckman; Robert E Hammer; Joachim Herz
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
The EMBO journal 2006;25(2):420-31.
2005: Elizabeth A Eckman; Christopher B Eckman
Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention.
Biochemical Society transactions 2005;33(Pt 5):1101-5.
2004: Wesley Farris; Stefan Mansourian; Malcolm Leissring; Elizabeth A Eckman; Lars Bertram; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
The American journal of pathology 2004;164(4):1425-34.
2003: Yang Chang; Giuseppina Tesco; William J Jeong; Loren Lindsley; Elizabeth A Eckman; Christopher B Eckman; Rudolph E Tanzi; Suzanne Y Guénette
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
The Journal of biological chemistry 2003;278(51):51100-7.
2003: Chastity Whitaker; Christopher B Eckman; Claudia Almeida; Douglas L Feinstein; Craig S Atwood; Elizabeth A Eckman; keith crutcher; Louis B Hersh; Malcolm Leissring; Matthew J LaVoie; Nilufer Ertekin-Taner; Paul Shapiro; Reisuke Takahashi; Rina yamin; Stefan Mansourian; Steven Estus; Sylvain Lesné; Tony Turner; Wes Farris; Gabrielle Stroebel
Live discussion: Amyloid-beta degradation: the forgotten half of Alzheimer's disease. 12 September 2002.
Journal of Alzheimer's disease : JAD 2003;5(6):491-7.
2003: Bonnie C Miller; Elizabeth A Eckman; Kumar Sambamurti; Nicole Dobbs; K Martin Chow; Christopher B Eckman; Louis B Hersh; Dwain L Thiele
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6221-6.
2003: Wesley Farris; Stefan Mansourian; Yang Chang; Loren Lindsley; Elizabeth A Eckman; Matthew P Frosch; Christopher B Eckman; Rudolph E Tanzi; Dennis J Selkoe; Suzanne Guenette
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4162-7.
2003: Elizabeth A Eckman; Mona Watson; Laura Marlow; Kumar Sambamurti; Christopher B Eckman
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
The Journal of biological chemistry 2003;278(4):2081-4.
2002: Debra Yager; Mona Watson; Brent Healy; Elizabeth A Eckman; Christopher B Eckman
Natural product extracts that reduce accumulation of the Alzheimer's amyloid beta peptide: selective reduction in A beta42.
Journal of molecular neuroscience : MN 2002;19(1-2):129-33.
2001: Sharie J Haugabook; Debra Yager; Elizabeth A Eckman; todd golde; Steven G Younkin; Christopher B Eckman
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta).
Journal of neuroscience methods 2001;108(2):171-9.
2001: Elizabeth A Eckman; Dana Kim Reed; Christopher B Eckman
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
The Journal of biological chemistry 2001;276(27):24540-8.
2001: Sharie J Haugabook; T Le; Debra Yager; Brenda M Zenk; B M Healy; Elizabeth A Eckman; CM Prada; Linda Younkin; P Murphy; Inga Pinnix; Luisa Onstead; Kumar Sambamurti; todd golde; dennis dickson; Steven G Younkin; Christopher B Eckman
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):16-18.
2000: Thomas Ferkol; Elizabeth A Eckman; S Swaidani; CL Silski; Pamela B Davis
Transport of bifunctional proteins across respiratory epithelial cells via the polymeric immunoglobulin receptor.
American journal of respiratory and critical care medicine 2000;161(3 Pt 1):944-51.
1999: Elizabeth A Eckman; WD Mallender; T Szegletes; CL Silski; John R Schreiber; Pamela B Davis; Thomas Ferkol
In vitro transport of active alpha(1)-antitrypsin to the apical surface of epithelia by targeting the polymeric immunoglobulin receptor.
American journal of respiratory cell and molecular biology 1999;21(2):246-52.
1996: Thomas Ferkol; A Pellicena-Palle; Elizabeth A Eckman; jose perales; T Trzaska; M Tosi; R Redline; Pamela B Davis
Immunologic responses to gene transfer into mice via the polymeric immunoglobulin receptor.
Gene therapy 1996;3(8):669-78.
1996: A Perez; K A Risma; Elizabeth A Eckman; Pamela B Davis
Overexpression of R domain eliminates cAMP-stimulated Cl- secretion in 9/HTEo- cells in culture.
The American journal of physiology 1996;271(1 Pt 1):L85-92.
1995: Elizabeth A Eckman; Calvin U Cotton; D M Kube; Pamela B Davis
Dietary changes improve survival of CFTR S489X homozygous mutant mouse.
The American journal of physiology 1995;269(5 Pt 1):L625-30.
1995: Thomas Ferkol; jose perales; Elizabeth A Eckman; C S Kaetzel; Richard W Hanson; Pamela B Davis
Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor.
The Journal of clinical investigation 1995;95(2):493-502.