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Diane Edelstein

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Xue-Liang Du; Diane Edelstein; Michael Brownlee
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Rabbani; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

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All Publications

2008: Xue-Liang Du; Diane Edelstein; Michael Brownlee
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Diabetologia 2008;51(10):1930-2.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Rabbani; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry 2007;282(42):31038-45.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2007;128(3):625.
2006: Xue-Liang Du; Diane Edelstein; Silvana Obici; Ninon Higham; Ming-Hui Zou; Michael Brownlee
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation.
The Journal of clinical investigation 2006;116(4):1071-80.
2006: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2006;124(2):275-86.
2004: Suseela Srinivasan; Melissa E Hatley; David T Bolick; Lisa A Palmer; Diane Edelstein; Michael Brownlee; Catherine C Hedrick
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells.
Diabetologia 2004;47(10):1727-34.
2003: Xue-Liang Du; Takeshi Matsumura; Diane Edelstein; Luciano Rossetti; Zsuzsanna Zsengellér; Csaba Szabó; Michael Brownlee
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
The Journal of clinical investigation 2003;112(7):1049-57.
2003: Hans-Peter Hammes; Xue-Liang Du; Diane Edelstein; Tetsuya Taguchi; Takeshi Matsumura; Qida Ju; Jihong Lin; Angelika Bierhaus; Peter Nawroth; Dieter Hannak; Michael Neumaier; Regine Bergfeld; Ida Giardino; Michael Brownlee
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Nature medicine 2003;9(3):294-9.
2002: Diana Casper; Samara J Engstrom; Gautam R Mirchandani; Ann Pidel; David Palencia; Paul H Cho; Michael Brownlee; Diane Edelstein; Howard Federoff; William J Sonstein
Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.
Cell transplantation 2002;11(4):331-49.
2001: Xue-Liang Du; Diane Edelstein; S Dimmeler; Qida Ju; C Sui; Michael Brownlee
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
The Journal of clinical investigation 2001;108(9):1341-8.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Y Kaneda; M Guzmán; Michael Brownlee
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.
The Journal of biological chemistry 2001;276(27):25096-100.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Michael Brownlee
Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction.
Diabetes 2001;50(6):1491-4.
2000: Xue-Liang Du; Diane Edelstein; L Rossetti; I George Fantus; Howard Goldberg; F Ziyadeh; J Wu; Michael Brownlee
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12222-6.
2000: Takeshi Nishikawa; Diane Edelstein; Michael Brownlee
The missing link: a single unifying mechanism for diabetic complications.
Kidney international. Supplement 2000;77():S26-30.
2000: T Nishikawa; Ida Giardino; Diane Edelstein; Michael Brownlee
Changes in diabetic retinal matrix protein mRNA levels in a common transgenic mouse strain.
Current eye research 2000;21(1):581-7.
2000: T Nishikawa; Diane Edelstein; Xue-Liang Du; SI Yamagishi; Takeshi Matsumura; Y Kaneda; M A Yorek; D Beebe; Peter Oates; Hans-Peter Hammes; Ida Giardino; Michael Brownlee
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Nature 2000;404(6779):787-90.
1999: Alex Rabinovitch; Wilma L Suarez-Pinzon; Ken Strynadka; Qida Ju; Diane Edelstein; Michael Brownlee; Gregory S Korbutt; Ray V Rajotte
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Diabetes 1999;48(6):1223-9.
1999: G Chan; Jay O Boyle; Eun K Yang; F Zhang; Peter G Sacks; Jatin P Shah; Diane Edelstein; Robert A Soslow; Alane T Koki; B Mark Woerner; Jaime L Masferrer; Andrew J Dannenberg
Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.
Cancer research 1999;59(5):991-4.
1999: Juan R Mestre; G Chan; F Zhang; Eun K Yang; Peter G Sacks; Jay O Boyle; Jatin P Shah; Diane Edelstein; Kotha Subbaramaiah; Andrew J Dannenberg
Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer.
Annals of the New York Academy of Sciences 1999;889():62-71.
1999: Michael D'Angelica; HM Karpoff; Marc W Halterman; J Ellis; David S Klimstra; Diane Edelstein; Michael Brownlee; Howard Federoff; Yuman Fong
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Cancer immunology, immunotherapy : CII 1999;47(5):265-71.
1998: A Khafif; Stimson P Schantz; M al-Rawi; Diane Edelstein; Peter G Sacks
Green tea regulates cell cycle progression in oral leukoplakia.
Head & neck 1998;20(6):528-34.
1998: Qida Ju; Diane Edelstein; M D Brendel; D Brandhorst; H Brandhorst; R G Bretzel; Michael Brownlee
Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector.
Diabetologia 1998;41(6):736-9.
1998: A Khafif; Stimson P Schantz; T C Chou; Diane Edelstein; Peter G Sacks
Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells.
Carcinogenesis 1998;19(3):419-24.
1996: Y Liu; Alex Rabinovitch; Wilma L Suarez-Pinzon; B Muhkerjee; Michael Brownlee; Diane Edelstein; Howard Federoff
Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis.
Human gene therapy 1996;7(14):1719-26.
1996: Ida Giardino; Diane Edelstein; Michael Brownlee
BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.
The Journal of clinical investigation 1996;97(6):1422-8.
1994: Ida Giardino; Diane Edelstein; Michael Brownlee
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.
The Journal of clinical investigation 1994;94(1):110-7.
1993: P Casaccia-Bonnefil; E Benedikz; H Shen; A Stelzer; Diane Edelstein; M Geschwind; Michael Brownlee; Howard Federoff; Peter Bergold
Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices.
Journal of neuroscience methods 1993;50(3):341-51.
1993: Yuman Fong; Diane Edelstein; E A Wang; Michael Brownlee
Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.
Diabetologia 1993;36(9):802-7.
1992: Diane Edelstein; Michael Brownlee
Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine.
Diabetes 1992;41(1):26-9.
1991: S T Crowley; Michael Brownlee; Diane Edelstein; J A Satriano; T Mori; Pravin Singhal; D O Schlondorff
Effects of nonenzymatic glycosylation of mesangial matrix on proliferation of mesangial cells.
Diabetes 1991;40(5):540-7.
1990: C J Mullarkey; Diane Edelstein; Michael Brownlee
Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes.
Biochemical and biophysical research communications 1990;173(3):932-9.
1989: C M Arbeeny; Charles Nordin; Diane Edelstein; N Stram; Nora Gibbons; H A Eder
Hyperlipoproteinemia in spontaneously diabetic guinea pigs.
Metabolism: clinical and experimental 1989;38(9):895-900.
1980: C M Arbeeny; Diane Edelstein; S R Freedman; H A Eder
Serum lipoproteins of diabetic rats fed a high cholesterol diet.
Diabetes 1980;29(10):774-7.