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Osborn Eden

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Anne-Marie Glenny; F Gibson; E Auld; S Coulson; J E Clarkson; J V Craig; Osborn B Eden; T Khalid; Helen V Worthington; B Pizer
The development of evidence-based guidelines on mouth care for children, teenagers and young adults treated for cancer.
A Ng; G Malcolm Taylor; Osborn B Eden
Genotoxicity of etoposide: greater susceptibility of MLL than other target genes.
Stefan Meyer; William Fergusson; Anneke B Oostra; Annette L Medhurst; Quinten Waisfisz; Johan P de Winter; Fei Chen; Trevor F Carr; Jill Clayton-Smith; Tara Clancy; Mike Green; Lisa Barber; Osborn B Eden; Andrew M Will; Hans Joenje; G Malcolm Taylor
A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations.

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All Publications

2010: Anne-Marie Glenny; F Gibson; E Auld; S Coulson; J E Clarkson; J V Craig; Osborn B Eden; T Khalid; Helen V Worthington; B Pizer
The development of evidence-based guidelines on mouth care for children, teenagers and young adults treated for cancer.
European journal of cancer (Oxford, England : 1990) 2010;46(8):1399-412.
2006: A Ng; G Malcolm Taylor; Osborn B Eden
Genotoxicity of etoposide: greater susceptibility of MLL than other target genes.
Cancer genetics and cytogenetics 2006;164(2):164-7.
2005: Stefan Meyer; William Fergusson; Anneke B Oostra; Annette L Medhurst; Quinten Waisfisz; Johan P de Winter; Fei Chen; Trevor F Carr; Jill Clayton-Smith; Tara Clancy; Mike Green; Lisa Barber; Osborn B Eden; Andrew M Will; Hans Joenje; G Malcolm Taylor
A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations.
Genes, chromosomes & cancer 2005;42(4):404-15.
2005: A Ng; G Malcolm Taylor; Robert F Wynn; Osborn B Eden
Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study.
Leukemia 2005;19(2):253-9.
2004: A Ng; Paul F Ravetto; G Malcolm Taylor; Robert F Wynn; Osborn B Eden
Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis.
British journal of cancer 2004;91(12):1990-2.
2004: Stefan Meyer; Helen Kingston; A Malcolm R Taylor; Philip J Byrd; James I K Last; Bernadette M D Brennan; Steve Trueman; Anna Kelsey; G Malcolm Taylor; Osborn B Eden
Rhabdomyosarcoma in Nijmegen breakage syndrome: strong association with perianal primary site.
Cancer genetics and cytogenetics 2004;154(2):169-74.
2004: Richard J Q McNally; Freda E Alexander; Osborn B Eden; Jillian M Birch
Little or no space-time clustering found amongst cases of childhood lymphoma in North West England.
European journal of cancer (Oxford, England : 1990) 2004;40(4):585-9.
2004: Frank G H Hill; Sue Richards; Brenda Gibson; Ian Hann; John Lilleyman; Sally E Kinsey; Christopher Mitchell; Christine J Harrison; Osborn B Eden
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172).
British journal of haematology 2004;124(1):33-46.
2003: G Malcolm Taylor; Helen P O'Brien; Mel F Greaves; Paul F Ravetto; Osborn B Eden
Correspondence re: R. Varon et al., Mutations in the Nijmegen breakage syndrome gene (NBS1) in childhood acute lymphoblastic leukemia. Cancer Res., 61: 3570-3572, 2001.
Cancer research 2003;63(19):6563-4; author reply 6565.
2003: Richard J Q McNally; Robert D Alston; Donal P Cairns; Osborn B Eden; Jillian M Birch
Geographical and ecological analyses of childhood acute leukaemias and lymphomas in north-west England.
British journal of haematology 2003;123(1):60-5.
2003: Richard J Q McNally; Robert D Alston; Donal P Cairns; Osborn B Eden; Anna M Kelsey; Jillian M Birch
Geographical and ecological analyses of childhood Wilms' tumours and soft-tissue sarcomas in North West England.
European journal of cancer (Oxford, England : 1990) 2003;39(11):1586-93.
2003: Paul F Ravetto; R Agarwal; Malcolm Chiswick; Stephen W D'Souza; Osborn B Eden; G Malcolm Taylor
Absence of leukaemic fusion gene transcripts in preterm infants exposed to diagnostic x rays.
Archives of disease in childhood. Fetal and neonatal edition 2003;88(3):F237-44.
2003: Lisa M Barber; Helen E N McGrath; Stefan Meyer; Andrew M Will; Jillian M Birch; Osborn B Eden; G Malcolm Taylor
Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia.
British journal of haematology 2003;121(1):57-62.
2003: Richard J Q McNally; Anna M Kelsey; Osborn B Eden; Freda E Alexander; Donal P Cairns; Jillian M Birch
Space-time clustering patterns in childhood solid tumours other than central nervous system tumours.
International journal of cancer. Journal international du cancer 2003;103(2):253-8.
2002: Helen Robson; S Meyer; Stephen M Shalet; E Anderson; Stephen Roberts; Osborn B Eden
Platinum agents in the treatment of osteosarcoma: efficacy of cisplatin vs. carboplatin in human osteosarcoma cell lines.
Medical and pediatric oncology 2002;39(6):573-80.
2002: G Malcolm Taylor; Simon P Dearden; Paul F Ravetto; Michelle Ayres; Pamela Watson; Adiba Hussain; Mel Greaves; Freda Alexander; Osborn B Eden
Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201.
Human molecular genetics 2002;11(14):1585-97.
2002: Richard J Q McNally; Donal P Cairns; Osborn B Eden; Freda E Alexander; G Malcolm Taylor; Anna M Kelsey; Jillian M Birch
An infectious aetiology for childhood brain tumours? Evidence from space-time clustering and seasonality analyses.
British journal of cancer 2002;86(7):1070-7.
2001: Richard J Q McNally; Anna M Kelsey; Donal P Cairns; G M Taylor; Osborn B Eden; Jillian M Birch
Temporal increases in the incidence of childhood solid tumors seen in Northwest England (1954-1998) are likely to be real.
Cancer 2001;92(7):1967-76.
2001: Richard J Q McNally; Donal P Cairns; Osborn B Eden; Anna M Kelsey; G Malcolm Taylor; Jillian M Birch
Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.
Leukemia 2001;15(10):1612-8.
2001: Jillian M Birch; Robert D Alston; R J McNally; D G R Evans; Anna M Kelsey; M Harris; Osborn B Eden; Jennifer M Varley
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Oncogene 2001;20(34):4621-8.
2001: Ana Teresa Maia; Anthony M Ford; G Reza Jalali; Christine J Harrison; G Malcolm Taylor; Osborn B Eden; Mel F Greaves
Molecular tracking of leukemogenesis in a triplet pregnancy.
Blood 2001;98(2):478-82.
2001: Ian Hann; Ajay Vora; G Harrison; C Harrison; Osborn B Eden; F Hill; Brenda Gibson; Sue Richards
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.
British journal of haematology 2001;113(1):103-14.
2001: Joseph L Wiemels; R N Smith; G Malcolm Taylor; Osborn B Eden; Freda E Alexander; Mel F Greaves
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4004-9.
2001: Jane MacKenzie; Alice Gallagher; Rob A Clayton; Jacqueline Perry; Osborn B Eden; Anthony M Ford; Mel F Greaves; Ruth F Jarrett
Screening for herpesvirus genomes in common acute lymphoblastic leukemia.
Leukemia 2001;15(3):415-21.
2000: Jillian M Birch; F E Alexander; V Blair; Osborn B Eden; G Malcolm Taylor; R J McNally
Space-time clustering patterns in childhood leukaemia support a role for infection.
British journal of cancer 2000;82(9):1571-6.
2000: Ian Hann; Ajay Vora; Sue Richards; F Hill; Brenda Gibson; John Lilleyman; Sally E Kinsey; Chris Mitchell; Osborn B Eden
Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
Leukemia 2000;14(3):356-63.
1999: Joseph L Wiemels; Giovanni Cazzaniga; M Daniotti; Osborn B Eden; G M Addison; G Masera; V Saha; Andrea Biondi; Mel F Greaves
Prenatal origin of acute lymphoblastic leukaemia in children.
Lancet 1999;354(9189):1499-503.
1999: Robert F Wynn; J D Grainger; Trevor F Carr; Osborn B Eden; Richard F Stevens; Andrew M Will
Failure of allogeneic bone marrow transplantation to correct Diamond-Blackfan anaemia despite haemopoietic stem cell engraftment.
Bone marrow transplantation 1999;24(7):803-5.
1999: G W Makin; Osborn B Eden; Linda S Lashford; J Moppett; M P Gerrard; H A Davies; Colin Powell; A N Campbell; H Frances
Leptomeningeal melanoma in childhood.
Cancer 1999;86(5):878-86.
1999: Joseph L Wiemels; A Pagnamenta; G Malcolm Taylor; Osborn B Eden; Freda E Alexander; Mel F Greaves
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
Cancer research 1999;59(16):4095-9.
1999: Osborn B Eden
Intensified treatment of acute childhood lymphoblastic leukaemia has improved prognosis, especially in non-high-risk patients. Nordic experience of 2648 patients diagnosed between 1981 and 1996 by Gustafsson et al.
Acta paediatrica (Oslo, Norway : 1992) 1999;88(4):360-2.
1999: Bernadette M D Brennan; Asad Rahim; J A Adams; Osborn B Eden; Stephen M Shalet
Reduced bone mineral density in young adults following cure of acute lymphoblastic leukaemia in childhood.
British journal of cancer 1999;79(11-12):1859-63.
1999: Bernadette M D Brennan; Asad Rahim; Werner Blum; J A Adams; Osborn B Eden; Stephen M Shalet
Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity?
Clinical endocrinology 1999;50(2):163-9.
1998: K Ghodsi; G Malcolm Taylor; David A Gokhale; Simon P Dearden; Richard F Stevens; Jillian M Birch; William Fergusson; Osborn B Eden; W Ollier
Lack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells.
British journal of haematology 1998;102(5):1279-83.
1998: G Malcolm Taylor; Simon P Dearden; N Payne; Michelle Ayres; David A Gokhale; Jillian M Birch; V Blair; Richard F Stevens; Andrew M Will; Osborn B Eden
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
British journal of cancer 1998;78(5):561-5.
1998: R M Westerbeek; V Blair; Osborn B Eden; Anna M Kelsey; Richard F Stevens; Andrew M Will; G Malcolm Taylor; Jillian M Birch
Seasonal variations in the onset of childhood leukaemia and lymphoma.
British journal of cancer 1998;78(1):119-24.
1998: Bernadette M D Brennan; Asad Rahim; E M Mackie; Osborn B Eden; Stephen M Shalet
Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood.
Clinical endocrinology 1998;48(6):777-83.
1998: Helen Robson; E Anderson; Osborn B Eden; O Isaksson; Stephen M Shalet
Chemotherapeutic agents used in the treatment of childhood malignancies have direct effects on growth plate chondrocyte proliferation.
The Journal of endocrinology 1998;157(2):225-35.
1998: E Hesketh; Osborn B Eden; H Rao Gattamaneni; Richard H A Campbell; M E Jenney; Linda S Lashford
Spinal cord compression--do we miss it?
Acta paediatrica (Oslo, Norway : 1992) 1998;87(4):452-4.
1998: Helen Robson; E Anderson; Osborn B Eden; O Isaksson; Stephen M Shalet
Glucocorticoid pretreatment reduces the cytotoxic effects of a variety of DNA-damaging agents on rat tibial growth-plate chondrocytes in vitro.
Cancer chemotherapy and pharmacology 1998;42(2):171-6.
1997: K B Gale; Anthony M Ford; R Repp; A Borkhardt; C Keller; Osborn B Eden; Mel F Greaves
Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13950-4.
1997: Osborn B Eden; J Birch; J Bruce; Richard H A Campbell; H Rao Gattamaneni; M E Jenney; E Jones; A Kelsey; Linda S Lashford; Richard F Stevens; Andrew M Will
Pediatric oncology and hematology in Manchester, England.
Pediatric hematology and oncology 1997;14(3):191-7.