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Allen Edmundson

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Andrew Hutchinson; Ralitza Alexova; Vanessa Bockhorni; Paul Ramsland; Darren R Jones; Cameron V Jennings; Kevin Broady; Allen B Edmundson; Robert L Raison
Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential.
Andrew Hutchinson; Paul A Ramsland; Darren R Jones; Mark Agostino; Maria E Lund; Cameron V Jennings; Vanessa Bockhorni; Elizabeth Yuriev; Allen B Edmundson; Robert L Raison
Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form.
Hiroaki Taguchi; Stephanie Planque; Yasuhiro Nishiyama; Jindrich Symersky; Stephane Boivin; Paul Szabo; Robert P Friedland; Paul Ramsland; Allen B Edmundson; Marc E Weksler; Sudhir Paul
Autoantibody-catalyzed hydrolysis of amyloid beta peptide.

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All Publications

2011: Andrew Hutchinson; Ralitza Alexova; Vanessa Bockhorni; Paul Ramsland; Darren R Jones; Cameron V Jennings; Kevin Broady; Allen B Edmundson; Robert L Raison
Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential.
Molecular immunology 2011;48(9-10):1245-52.
2010: Andrew Hutchinson; Paul A Ramsland; Darren R Jones; Mark Agostino; Maria E Lund; Cameron V Jennings; Vanessa Bockhorni; Elizabeth Yuriev; Allen B Edmundson; Robert L Raison
Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4179-88.
2008: Hiroaki Taguchi; Stephanie Planque; Yasuhiro Nishiyama; Jindrich Symersky; Stephane Boivin; Paul Szabo; Robert P Friedland; Paul Ramsland; Allen B Edmundson; Marc E Weksler; Sudhir Paul
Autoantibody-catalyzed hydrolysis of amyloid beta peptide.
The Journal of biological chemistry 2008;283(8):4714-22.
2007: Vicky Vallas; William Farrugia; Robert L Raison; Allen B Edmundson; Paul Ramsland
Dissimilar aggregation processes govern precipitation and gelation of human IgM cryoglobulins.
Journal of molecular recognition : JMR 2007;20(2):90-6.
2006: Paul Ramsland; Simon Terzyan; Gwendolyn Cloud; Christina R Bourne; William Farrugia; Gordon Tribbick; H Mario Geysen; Carolyn R Moomaw; Clive A Slaughter; Allen B Edmundson
Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody.
The Biochemical journal 2006;395(3):473-81.
2004: Philip C Bourne; Simon Terzyan; Gwendolyn Cloud; Nicholas F Landolfi; Maximiliano Vásquez; Allen B Edmundson
Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1761-9.
2004: Simon Terzyan; Paul Ramsland; Edward W Voss; James N Herron; Allen B Edmundson
Three-dimensional structures of idiotypically related Fabs with intermediate and high affinity for fluorescein.
Journal of molecular biology 2004;339(5):1141-51.
2003: Christer Wingren; Allen B Edmundson; Carl A K Borrebaeck
Designing proteins to crystallize through beta-strand pairing.
Protein engineering 2003;16(4):255-64.
2003: Paul Ramsland; William Farrugia; Elizabeth Yuriev; Allen B Edmundson; Mauro S Sandrin
Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(2):307-17.
2003: Simon Terzyan; Christina R Bourne; Paul Ramsland; Philip C Bourne; Allen B Edmundson
Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95.
Journal of molecular recognition : JMR 2003;16(2):83-90.
2002: Denis C Shaw; Brandon B Shultz; Paul Ramsland; Allen B Edmundson
Dealing with intractable protein cores: protein sequencing of the Mcg IgG and the Yvo IgM heavy chain variable domains.
Journal of molecular recognition : JMR 2002;15(5):341-8.
2002: B Leif Hanson; Gerard J. Bunick; Joel M Harp; Allen B Edmundson
Mcg in 2030: new techniques for atomic position determination of immune complexes.
Journal of molecular recognition : JMR 2002;15(5):297-305.
2002: Allen B Edmundson
Reminiscences: joyous moments along the road from here to there and back again.
Journal of molecular recognition : JMR 2002;15(5):227-39.
2002: Ian F Robey; Allen B Edmundson; Samuel F Schluter; David E Yocum; John J Marchalonis
Specificity mapping of human anti-T cell receptor monoclonal natural antibodies: defining the properties of epitope recognition promiscuity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(7):642-52.
2002: Philip C Bourne; Paul Ramsland; Lin Shan; Zhao C Fan; Christina R DeWitt; Brandon B Shultz; Simon Terzyan; Carolyn R Moomaw; Clive A Slaughter; Luke W Guddat; Allen B Edmundson
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 5):815-23.
2002: Elizabeth Yuriev; Paul Ramsland; Allen B Edmundson
Recognition of IgG-derived peptides by a human IgM with an unusual combining site.
Scandinavian journal of immunology 2002;55(3):242-55.
2001: Paul Ramsland; Elizabeth Yuriev; Allen B Edmundson
Immunoglobulin cross-reactivity examined by library screening, crystallography and docking studies.
Combinatorial chemistry & high throughput screening 2001;4(5):397-408.
2001: Allen B Edmundson; Gordon Tribbick; S Plompen; H Mario Geysen; Elizabeth Yuriev; Paul Ramsland
Binding of synthetic peptides by a human monoclonal IgM with an unusual combining site structure.
Journal of molecular recognition : JMR 2001;14(4):229-38.
2001: Elizabeth Yuriev; Paul Ramsland; Allen B Edmundson
Docking of combinatorial peptide libraries into a broadly cross-reactive human IgM.
Journal of molecular recognition : JMR 2001;14(3):172-84.
2001: C V Manion; J Howard; B Ogle; J Parkhurst; Allen B Edmundson
Aspartame effect in sickle cell anemia.
Clinical pharmacology and therapeutics 2001;69(5):346-55.
2001: John J Marchalonis; Miranda K Adelman; Ian F Robey; Samuel F Schluter; Allen B Edmundson
Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans.
Journal of molecular recognition : JMR 2001;14(2):110-21.
2001: Paul Ramsland; Azad Kaushik; John J Marchalonis; Allen B Edmundson
Incorporation of long CDR3s into V domains: implications for the structural evolution of the antibody-combining site.
Experimental and clinical immunogenetics 2001;18(4):176-98.
2001: John J Marchalonis; Ian F Robey; Allen B Edmundson; R T Sepulveda; Ronald R Watson
T-cell receptor-derived peptides in immunoregulation and therapy of retrovirally induced immunosuppression.
Critical reviews in immunology 2001;21(1-3):57-74.
2000: Luke W Guddat; Lin Shan; C Broomell; Paul Ramsland; Z Fan; JM Anchin; Darwin S Linthicum; Allen B Edmundson
The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.
Journal of molecular biology 2000;302(4):853-72.
2000: D L Harris; E King; Paul Ramsland; Allen B Edmundson
Binding of nascent collagen by amyloidogenic light chains and amyloid fibrillogenesis in monolayers of human fibrocytes.
Journal of molecular recognition : JMR 2000;13(4):198-212.
2000: Paul Ramsland; Lin Shan; Carolyn R Moomaw; Clive A Slaughter; Z Fan; Luke W Guddat; Allen B Edmundson
An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands.
Molecular immunology 2000;37(6):295-310.
1999: Paul Ramsland; B F Movafagh; Morris Reichlin; Allen B Edmundson
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.
Journal of molecular recognition : JMR 1999;12(5):249-57.
1999: Paul Ramsland; B F Movafagh; Morris Reichlin; Allen B Edmundson
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.
Journal of molecular recognition : JMR 1999;12(4):249-57.
1999: Paul Ramsland; C R Brock; J Moses; B G Robinson; Allen B Edmundson; Robert L Raison
Structural aspects of human IgM antibodies expressed in chronic B lymphocytic leukemia.
Immunotechnology : an international journal of immunological engineering 1999;4(3-4):217-29.
1999: Z C Fan; Lin Shan; B Z Goldsteen; Luke W Guddat; A Thakur; Nicholas F Landolfi; Man Sung Co; Maximiliano Vasquez; C Queen; Paul Ramsland; Allen B Edmundson
Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody.
Journal of molecular recognition : JMR 1999;12(1):19-32.
1998: Allen B Edmundson; C V Manion
Treatment of osteoarthritis with aspartame.
Clinical pharmacology and therapeutics 1998;63(5):580-93.
1998: John J Marchalonis; Samuel F Schluter; Ralph M Bernstein; S Shen; Allen B Edmundson
Phylogenetic emergence and molecular evolution of the immunoglobulin family.
Advances in immunology 1998;70():417-506.
1998: Allen B Edmundson; Carl A K Borrebaeck
Progress in programming antibody fragments to crystallize.
Immunotechnology : an international journal of immunological engineering 1998;3(4):309-17.
1998: C Faber; Lin Shan; Z Fan; Luke W Guddat; Christina Furebring; Mats Ohlin; Carl A K Borrebaeck; Allen B Edmundson
Three-dimensional structure of a human Fab with high affinity for tetanus toxoid.
Immunotechnology : an international journal of immunological engineering 1998;3(4):253-70.
1997: John J Marchalonis; Samuel F Schluter; Allen B Edmundson
The T-cell receptor as immunoglobulin: paradigm regained.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1997;216(3):303-18.
1997: Paul Ramsland; Luke W Guddat; Allen B Edmundson; Robert L Raison
Diverse binding site structures revealed in homology models of polyreactive immunoglobulins.
Journal of computer-aided molecular design 1997;11(5):453-61.
1996: Luke W Guddat; J A Martin; L Shan; Allen B Edmundson; W R Gray
Three-dimensional structure of the alpha-conotoxin GI at 1.2 A resolution.
Biochemistry 1996;35(35):11329-35.
1995: Luke W Guddat; Lin Shan; Z C Fan; K N Andersen; R Rosauer; Darwin S Linthicum; Allen B Edmundson
Intramolecular signaling upon complexation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(1):101-6.
1994: J N Herron; A H Terry; S Johnston; X M He; Luke W Guddat; E W Voss; Allen B Edmundson
High resolution structures of the 4-4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity.
Biophysical journal 1994;67(6):2167-83.
1994: Douglas F. Lake; Samuel F Schluter; E Wang; Ralph M Bernstein; Allen B Edmundson; John J Marchalonis
Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10849-53.
1994: John J Marchalonis; Samuel F Schluter; E Wang; K Dehghanpisheh; Douglas F. Lake; D E Yocum; Allen B Edmundson; J B Winfield
Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;207(2):129-47.
1994: John J Marchalonis; V S Hohman; H Kaymaz; Samuel F Schluter; Allen B Edmundson
Cell surface recognition and the immunoglobulin superfamily.
Annals of the New York Academy of Sciences 1994;712():20-33.
1994: Luke W Guddat; Lin Shan; J M Anchin; Darwin S Linthicum; Allen B Edmundson
Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
Journal of molecular biology 1994;236(1):247-74.
1994: Allen B Edmundson; Luke W Guddat; Lin Shan; Z C Fan; B L Hanson
Structural aspects of conformational changes in ligand binding by antibody fragments.
Research in immunology 1994;145(1):56-61.
1994: H Kaymaz; F Dedeoglu; Samuel F Schluter; Allen B Edmundson; John J Marchalonis
Cross-reactions of anti-immunoglobulin sera with synthetic T-cell receptor beta peptides: mapping on a 3-dimension model.
Advances in experimental medicine and biology 1994;347():93-8.
1993: Allen B Edmundson; D L Harris; Z C Fan; Luke W Guddat; B T Schley; B L Hanson; G Tribbick; H M Geysen
Principles and pitfalls in designing site-directed peptide ligands.
Proteins 1993;16(3):246-67.
1993: Luke W Guddat; J N Herron; Allen B Edmundson
Three-dimensional structure of a human immunoglobulin with a hinge deletion.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4271-5.
1993: H Kaymaz; F Dedeoglu; Samuel F Schluter; Allen B Edmundson; John J Marchalonis
Reactions of anti-immunoglobulin sera with synthetic T cell receptor peptides: implications for the three-dimensional structure and function of the TCR beta chain.
International immunology 1993;5(5):491-502.
1992: Z C Fan; Lin Shan; Luke W Guddat; X M He; W R Gray; Robert L Raison; Allen B Edmundson
Three-dimensional structure of an Fv from a human IgM immunoglobulin.
Journal of molecular biology 1992;228(1):188-207.
1992: John J Marchalonis; H Kaymaz; F Dedeoglu; Samuel F Schluter; D E Yocum; Allen B Edmundson
Human autoantibodies reactive with synthetic autoantigens from T-cell receptor beta chain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3325-9.
1992: John J Marchalonis; F Dedeoglu; H Kaymaz; Samuel F Schluter; Allen B Edmundson
Antigenic mapping of a human lambda light chain: correlation with three dimensional structure.
Journal of protein chemistry 1992;11(2):129-37.
1991: Allen B Edmundson; D L Harris; G Tribbick; H M Geysen
Binding of peptides to proteins: an exercise in molecular design.
Ciba Foundation symposium 1991;158():213-25; discussion 225-30.
1991: John J Marchalonis; F Dedeoglu; V S Hohman; K McGee; Samuel F Schluter; Allen B Edmundson
Antigenic mapping of light chains and T cell receptor beta chains.
Advances in experimental medicine and biology 1991;303():235-42.
1991: J N Herron; X M He; D W Ballard; P R Blier; P E Pace; A L Bothwell; E W Voss; Allen B Edmundson
An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex.
Proteins 1991;11(3):159-75.
1990: Kathryn R Ely; J N Herron; Allen B Edmundson
Three-dimensional structure of a hybrid light chain dimer: protein engineering of a binding cavity.
Molecular immunology 1990;27(2):101-14.
1990: W D Bedzyk; J N Herron; Allen B Edmundson; Edward W Voss
Active site structure and antigen binding properties of idiotypically cross-reactive anti-fluorescein monoclonal antibodies.
The Journal of biological chemistry 1990;265(1):133-8.
1989: Kathryn R Ely; J N Herron; M Harker; Allen B Edmundson
Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms.
Journal of molecular biology 1989;210(3):601-15.
1989: Samuel F Schluter; V S Hohman; Allen B Edmundson; John J Marchalonis
Evolution of immunoglobulin light chains: cDNA clones specifying sandbar shark constant regions.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9961-5.
1989: G Tribbick; Allen B Edmundson; T J Mason; H M Geysen
Similar binding properties of peptide ligands for a human immunoglobulin and its light chain dimer.
Molecular immunology 1989;26(7):625-35.
1989: Allen B Edmundson; J N Herron; Kathryn R Ely; X M He; D L Harris; E W Voss
Synthetic site-directed ligands.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;323(1217):495-509.
1989: Allen B Edmundson; Kathryn R Ely; X M He; J N Herron
Cocrystallization of an immunoglobulin light chain dimer with bis(dinitrophenyl) lysine: tandem binding of two ligands, one with and one without accompanying conformational changes in the protein.
Molecular immunology 1989;26(3):207-20.
1989: J N Herron; X M He; M L Mason; E W Voss; Allen B Edmundson
Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol.
Proteins 1989;5(4):271-80.
1988: A L Gibson; J N Herron; X M He; V A Patrick; M L Mason; J N Lin; David M Kranz; E W Voss; Allen B Edmundson
Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems.
Proteins 1988;3(3):155-60.
1987: Robert L Raison; Allen B Edmundson
Localization of an idiotope on the L chain dimer and intact IgG1 immunoglobulin from the patient Mcg.
Molecular immunology 1987;24(9):937-43.
1987: Allen B Edmundson; Kathryn R Ely; J N Herron; B D Cheson
The binding of opioid peptides to the Mcg light chain dimer: flexible keys and adjustable locks.
Molecular immunology 1987;24(9):915-35.
1987: D C Shaw; D L Harris; X M He; J A Oster; D L Montgomery; Kathryn R Ely; Allen B Edmundson
A mild method for the preparation of disulfide-linked hybrids of immunoglobulin light chains.
Molecular immunology 1987;24(3):267-74.
1986: Allen B Edmundson; Kathryn R Ely
Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the Mcg light chain dimer.
Ciba Foundation symposium 1986;119():107-29.
1985: J N Herron; Kathryn R Ely; Allen B Edmundson
Pressure-induced conformational changes in a human Bence-Jones protein (Mcg).
Biochemistry 1985;24(14):3453-9.
1985: Allen B Edmundson; Kathryn R Ely
Binding of N-formylated chemotactic peptides in crystals of the Mcg light chain dimer: similarities with neutrophil receptors.
Molecular immunology 1985;22(4):463-75.
1985: A L Gibson; J N Herron; D W Ballard; E W Voss; X M He; V A Patrick; Allen B Edmundson
Crystallographic characterization of the Fab fragment of a monoclonal anti-ss-DNA antibody.
Molecular immunology 1985;22(4):499-502.
1985: Allen B Edmundson; Kathryn R Ely
The Mcg light chain: multiple conformations derived from a single amino acid sequence.
Annales de l'Institut Pasteur. Immunologie 1985;136C(2):276-82.
1985: Kathryn R Ely; M K Wood; S S Rajan; J M Hodsdon; E E Abola; H F Deutsch; Allen B Edmundson
Unexpected similarities in the crystal structures of the Mcg light-chain dimer and its hybrid with the Weir protein.
Molecular immunology 1985;22(2):93-100.
1985: Kathryn R Ely; David S Peabody; T R Holm; B D Cheson; Allen B Edmundson
Accessible intrachain disulfide bonds in hybrids of light chains.
Molecular immunology 1985;22(2):85-92.
1984: Allen B Edmundson; Kathryn R Ely; J N Herron
A search for site-filling ligands in the Mcg Bence-Jones dimer: crystal binding studies of fluorescent compounds.
Molecular immunology 1984;21(7):561-76.
1983: S S Rajan; Kathryn R Ely; E E Abola; M K Wood; P M Colman; R J Athay; Allen B Edmundson
Three-dimensional structure of the Mcg IgG1 immunoglobulin.
Molecular immunology 1983;20(7):787-99.
1980: David S Peabody; Kathryn R Ely; Allen B Edmundson
Obligatory hybridization of heterologous immunoglobulin light chains into covalently linked dimers.
Biochemistry 1980;19(13):2827-34.
1980: E E Abola; Kathryn R Ely; Allen B Edmundson
Marked structural differences of the Mcg Bence--Jones dimer in two crystal systems.
Biochemistry 1980;19(3):432-9.