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Bruce Edwards

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J Jacob Strouse; George Tegos; Oleg Ursu; Anna Waller; Susan M Young; Cristian Bologa; Mark B Carter; Bruce S Edwards; Annette M Evangelisti; Irena Ivnitski-Steele; Richard Larson; Tudor I Oprea; Dominique Perez; VM Salas; Larry A Sklar
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.
Kevin W Cushing; Bruce S Edwards; Steven W Graves; Beth Ann López; Gian C Maestas; Menake E Piyasena; Nick J Carroll; Gabriel P López
Elastomeric negative acoustic contrast particles for affinity capture assays.
J Jacob Strouse; George P Tegos; Oleg Ursu; Anna Waller; Warren S Weiner; Tuanli Yao; Susan M Young; Jeffrey Aubé; Cristian Bologa; Mark B Carter; Stephanie E Chavez; Bruce S Edwards; Annette M Evangelisti; Terry D Foutz; Matthew J Garcia; Jennifer E Golden; Kristine Gouveia; Irena Ivnitski-Steele; Hadya M Khawaja; Richard Larson; Kelin Li; Brooks E Maki; Tudor I Oprea; Dominique Perez; Jerec Ricci; VM Salas; Chad E Schroeder; Denise S Simpson; Larry A Sklar
A selective ATP-binding cassette subfamily g member 2 efflux inhibitor revealed via high-throughput flow cytometry.

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All Publications

2013: J Jacob Strouse; George Tegos; Oleg Ursu; Anna Waller; Susan M Young; Cristian Bologa; Mark B Carter; Bruce S Edwards; Annette M Evangelisti; Irena Ivnitski-Steele; Richard Larson; Tudor I Oprea; Dominique Perez; VM Salas; Larry A Sklar
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters.
Analytical biochemistry 2013;437(1):77-87.
2013: Kevin W Cushing; Bruce S Edwards; Steven W Graves; Beth Ann López; Gian C Maestas; Menake E Piyasena; Nick J Carroll; Gabriel P López
Elastomeric negative acoustic contrast particles for affinity capture assays.
Analytical chemistry 2013;85(4):2208-15.
2013: J Jacob Strouse; George P Tegos; Oleg Ursu; Anna Waller; Warren S Weiner; Tuanli Yao; Susan M Young; Jeffrey Aubé; Cristian Bologa; Mark B Carter; Stephanie E Chavez; Bruce S Edwards; Annette M Evangelisti; Terry D Foutz; Matthew J Garcia; Jennifer E Golden; Kristine Gouveia; Irena Ivnitski-Steele; Hadya M Khawaja; Richard Larson; Kelin Li; Brooks E Maki; Tudor I Oprea; Dominique Perez; Jerec Ricci; VM Salas; Chad E Schroeder; Denise S Simpson; Larry A Sklar
A selective ATP-binding cassette subfamily g member 2 efflux inhibitor revealed via high-throughput flow cytometry.
Journal of biomolecular screening 2013;18(1):26-38.
2012: Bruce S Edwards; Steven W Graves; Mark B Carter; Jun Chen; John J G Tesmer; David M Thal; Jingshu Zhu; Larry A Sklar
Cluster cytometry for high-capacity bioanalysis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012;81(5):419-29.
2012: Jun Chen; Claudio de Virgilio; Bruce S Edwards; Terry D Foutz; Jennifer E Golden; Huining Kang; Robbie J Loewith; Nicolas Panchaud; Marie-Pierre Péli-Gulli; Blake R Peterson; Andrew Seeber; Chris Allen; Jeffrey Aubé; Cristian Bologa; Mark B Carter; J Jacob Strouse; Oleg Ursu; Anna Waller; Margaret Werner-Washburne; Tuanli Yao; Susan M Young; Larry A Sklar
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
ACS chemical biology 2012;7(4):715-22.
2011: Ramona F Curpan; Bruce S Edwards; Tudor I Oprea; John C Reed; Arnold C Satterthwait; Peter C Simons; Cristian Bologa; Mark B Carter; Susan M Young; Dayong Zhai; Larry A Sklar
High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.
Assay and drug development technologies 2011;9(5):465-74.
2011: Peter C Simons; Mark B Carter; Bruce S Edwards; John C Reed; Anna Waller; Susan M Young; Dayong Zhai; Larry A Sklar
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples.
Nature protocols 2011;6(7):943-52.
2010: Zurab Surviladze; Anna Waller; Yang Wu; Elsa Romero; Bruce S Edwards; Angela Wandinger-Ness; Larry A Sklar
Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.
Journal of biomolecular screening 2010;15(1):10-20.
2009: Mark K Haynes; J Jacob Strouse; Anna Waller; Andrei Leitao; Ramona F Curpan; Cristian Bologa; Tudor I Oprea; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar; Todd A Thompson
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system.
Journal of biomolecular screening 2009;14(6):596-609.
2009: J Jacob Strouse; Susan M Young; Hugh D Mitchell; Richard D Ye; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):264-70.
2009: Susan M Young; Cristian M Bologa; Dan Fara; Bj K Bryant; Juan Jacob Strouse; Jeffrey B Arterburn; Richard D Ye; Tudor I Oprea; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(3):253-63.
2009: Jeffrey B Arterburn; Tudor I Oprea; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar
Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30.
Current topics in medicinal chemistry 2009;9(13):1227-36.
2009: Bruce S Edwards; Susan M Young; Irena Ivnitsky-Steele; Richard D Ye; Eric R Prossnitz; Larry A Sklar
High-content screening: flow cytometry analysis.
Methods in molecular biology (Clifton, N.J.) 2009;486():151-65.
2008: Megan K Dennis; Harmony J C Bowles; Debra A MacKenzie; Scott W Burchiel; Bruce S Edwards; Larry A Sklar; Eric R Prossnitz; Todd A Thompson
A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2008;73(5):390-9.
2008: Irena Ivnitski-Steele; Richard Larson; Debbie M Lovato; Hadya M Khawaja; Stuart S Winter; Tudor I Oprea; Larry A Sklar; Bruce S Edwards
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters.
Assay and drug development technologies 2008;6(2):263-76.
2008: Stuart S Winter; Debbie M Lovato; Hadya M Khawaja; Bruce S Edwards; Irena D Steele; Susan M Young; Tudor I Oprea; Larry A Sklar; Richard Larson
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent.
Journal of biomolecular screening 2008;13(3):185-93.
2008: VM Salas; Bruce S Edwards; Larry A Sklar
Advances in multiple analyte profiling.
Advances in clinical chemistry 2008;45():47-74.
2007: Mark A Naivar; Jimmie D Parson; Mark E Wilder; Robert C Habbersett; Bruce S Edwards; Larry A Sklar; John P Nolan; Steven W Graves; John C Martin; James H Jett; James P Freyer
Open, reconfigurable cytometric acquisition system: ORCAS.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(11):915-24.
2007: Larry A Sklar; Mark B Carter; Bruce S Edwards
Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening.
Current opinion in pharmacology 2007;7(5):527-34.
2007: Peter C Simons; Susan M Young; Veronica Gibaja; Wen-Cherng Lee; Serene Josiah; Bruce S Edwards; Larry A Sklar
Duplexed, bead-based competitive assay for inhibitors of protein kinases.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2007;71(7):451-9.
2006: Eric R Prossnitz; Larry A Sklar; Jeffrey B Arterburn; Bruce S Edwards; Tudor I Oprea
Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands.
Expert opinion on drug discovery 2006;1(2):137-50.
2006: Matthew J Saunders; Heungbok Kim; Travis A Woods; John P Nolan; Larry A Sklar; Bruce S Edwards; Steven W Graves
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(5):342-52.
2006: Cristian Bologa; Chetana M Revankar; Susan M Young; Bruce S Edwards; Jeffrey B Arterburn; Alexander S Kiselyov; Matthew A Parker; Sergey E Tkachenko; Nikolay P Savchuck; Larry A Sklar; Tudor I Oprea; Eric R Prossnitz
Virtual and biomolecular screening converge on a selective agonist for GPR30.
Nature chemical biology 2006;2(4):207-12.
2006: Bruce S Edwards; Susan M Young; Tudor I Oprea; Cristian Bologa; Eric R Prossnitz; Larry A Sklar
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform.
Nature protocols 2006;1(1):59-66.
2006: Karla Melendez; Erik S Wallen; Bruce S Edwards; Charlotte D Mobarak; David G Bear; Pope L Moseley
Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells.
Cell stress & chaperones 2006;11(4):334-42.
2005: Bruce S Edwards; Cristian Bologa; Susan M Young; Konstantin V Balakin; Eric R Prossnitz; Nikolay P Savchuck; Larry A Sklar; Tudor I Oprea
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists.
Molecular pharmacology 2005;68(5):1301-10.
2005: Tudor I Oprea; Cristian Bologa; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Post-high-throughput screening analysis: an empirical compound prioritization scheme.
Journal of biomolecular screening 2005;10(5):419-26.
2005: Susan M Young; Cristian Bologa; Eric R Prossnitz; Tudor I Oprea; Larry A Sklar; Bruce S Edwards
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.
Journal of biomolecular screening 2005;10(4):374-82.
2004: Anna Waller; Peter C Simons; Sean M Biggs; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Techniques: GPCR assembly, pharmacology and screening by flow cytometry.
Trends in pharmacological sciences 2004;25(12):663-9.
2004: Gordon Zwartz; Alexandre Chigaev; Denise C Dwyer; Terry D Foutz; Bruce S Edwards; Larry A Sklar
Real-time analysis of very late antigen-4 affinity modulation by shear.
The Journal of biological chemistry 2004;279(37):38277-86.
2004: Bruce S Edwards; Tudor I Oprea; Eric R Prossnitz; Larry A Sklar
Flow cytometry for high-throughput, high-content screening.
Current opinion in chemical biology 2004;8(4):392-8.
2004: Alexandre Chigaev; Gordon Zwartz; Tione Buranda; Bruce S Edwards; Eric R Prossnitz; Larry A Sklar
Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.
The Journal of biological chemistry 2004;279(31):32435-43.
2004: Joseph W Bartsch; Hy D Tran; Anna Waller; Andrea A Mammoli; Tione Buranda; Larry A Sklar; Bruce S Edwards
An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system.
Analytical chemistry 2004;76(13):3810-7.
2004: Larry A Sklar; H Tsuji; Bruce S Edwards; Richard Larson; Mark Schuyler
Eosinophil traffic in the circulation following allergen challenge.
Allergy 2004;59(6):596-605.
2004: Susan M Young; Mark S Curry; John T Ransom; Juan A Ballesteros; Eric R Prossnitz; Larry A Sklar; Bruce S Edwards
High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening.
Journal of biomolecular screening 2004;9(2):103-11.
2003: Alexandre Chigaev; Gordon Zwartz; Steven W Graves; Denise C Dwyer; Hisashi Tsuji; Terry D Foutz; Bruce S Edwards; Eric R Prossnitz; Richard Larson; Larry A Sklar
Alpha4beta1 integrin affinity changes govern cell adhesion.
The Journal of biological chemistry 2003;278(40):38174-82.
2003: Anna Waller; Peter C Simons; Eric R Prossnitz; Bruce S Edwards; Larry A Sklar
High throughput screening of G-protein coupled receptors via flow cytometry.
Combinatorial chemistry & high throughput screening 2003;6(4):389-97.
2003: Sergio Ramirez; Charity T Aiken; Brett Andrzejewski; Larry A Sklar; Bruce S Edwards
High-throughput flow cytometry: validation in microvolume bioassays.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2003;53(1):55-65.
2002: W Coyt Jackson; Teresa A Bennett; Bruce S Edwards; Eric R Prossnitz; Gabriel P Lopez; Larry A Sklar
Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry.
BioTechniques 2002;33(1):220-6.
2002: W Coyt Jackson; FW Kuckuck; Bruce S Edwards; Andrea A Mammoli; C M Gallegos; Gabriel P Lopez; Tione Buranda; Larry A Sklar
Mixing small volumes for continuous high-throughput flow cytometry: performance of a mixing Y and peristaltic sample delivery.
Cytometry 2002;47(3):183-91.
2002: Larry A Sklar; Bruce S Edwards; Steven W Graves; John P Nolan; Eric R Prossnitz
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies.
Annual review of biophysics and biomolecular structure 2002;31():97-119.
2001: Alexandre Chigaev; A M Blenc; J V Braaten; N Kumaraswamy; Christopher L Kepley; Ronald P Andrews; Janet M Oliver; Bruce S Edwards; Eric R Prossnitz; Richard Larson; Larry A Sklar
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.
The Journal of biological chemistry 2001;276(52):48670-8.
2001: FW Kuckuck; Bruce S Edwards; Larry A Sklar
High throughput flow cytometry.
Cytometry 2001;44(1):83-90.
2001: Bruce S Edwards; FW Kuckuck; Eric R Prossnitz; John T Ransom; Larry A Sklar
HTPS flow cytometry: a novel platform for automated high throughput drug discovery and characterization.
Journal of biomolecular screening 2001;6(2):83-90.
2001: Bruce S Edwards; FW Kuckuck; Eric R Prossnitz; A Okun; John T Ransom; Larry A Sklar
Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology.
Cytometry 2001;43(3):211-6.
2000: Scott W Burchiel; Bruce S Edwards; FW Kuckuck; Fredine T Lauer; Eric R Prossnitz; John T Ransom; Larry A Sklar
Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications.
Methods (San Diego, Calif.) 2000;21(3):221-30.
2000: Bruce S Edwards; Mark S Curry; H Tsuji; D Brown; Richard Larson; Larry A Sklar
Expression of P-selectin at low site density promotes selective attachment of eosinophils over neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):404-10.
2000: Teresa A Bennett; Bruce S Edwards; Larry A Sklar; S Rogelj
Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4120-9.
1999: Bruce S Edwards; FW Kuckuck; Larry A Sklar
Plug flow cytometry: An automated coupling device for rapid sequential flow cytometric sample analysis.
Cytometry 1999;37(2):156-9.
1998: E Lynam; Larry A Sklar; AD Taylor; Sriram Neelamegham; Bruce S Edwards; C Wayne Smith; Scott I Simon
Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells.
Journal of leukocyte biology 1998;64(5):622-30.
1998: Bruce S Edwards; E A Southon; Mark S Curry; F Salazar; James Gale; M K Robinson; L H Graf; J L Born
Oxidant inhibition of alphaLbeta2 integrin adhesion: evidence for coordinate effects on conformation and cytoskeleton linkage.
Journal of leukocyte biology 1998;63(2):190-202.