FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Dean Edwards

Research Profile

Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Disorders

Breast Neoplasms

Physiology

Anatomy

Phenomena

Living Beings

Mouse Mammary Tumor Viruses

Co-author Network

Publications

TOP 3
Lindsey S Treviño; William E Bingman; Dean P Edwards; Weigel Nl
The requirement for p42/p44 MAPK activity in progesterone receptor-mediated gene regulation is target gene-specific.
Carolyn L Smith; Meng-Fen Wu; Margaret C Pace; Vaishali Chaubal; Dean P Edwards; M Carolina Gutiérrez; Ryan Hartmaier; Susan G Hilsenbeck; Shiming Jiang; Ilenia Migliaccio; Steffi Oesterreich
Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence.
Alison E Obr; Dean P Edwards
The biology of progesterone receptor in the normal mammary gland and in breast cancer.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Dean Edwards (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Lindsey S Treviño; William E Bingman; Dean P Edwards; Weigel Nl
The requirement for p42/p44 MAPK activity in progesterone receptor-mediated gene regulation is target gene-specific.
Steroids 2013;78(6):542-7.
2012: Carolyn L Smith; Meng-Fen Wu; Margaret C Pace; Vaishali Chaubal; Dean P Edwards; M Carolina Gutiérrez; Ryan Hartmaier; Susan G Hilsenbeck; Shiming Jiang; Ilenia Migliaccio; Steffi Oesterreich
Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence.
Breast cancer research and treatment 2012;136(1):253-65.
2012: Alison E Obr; Dean P Edwards
The biology of progesterone receptor in the normal mammary gland and in breast cancer.
Molecular and cellular endocrinology 2012;357(1-2):4-17.
2011: Adam C Buser; Alison E Obr; Elena B Kabotyanski; Sandra L Grimm; Jeffrey M Rosen; Dean P Edwards
Progesterone receptor directly inhibits β-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications.
Molecular endocrinology (Baltimore, Md.) 2011;25(6):955-68.
2010: Suzanne E Wardell; Ramesh Narayanan; Nancy L Weigel; Dean P Edwards
Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):335-45.
2009: John P Lydon; Dean P Edwards
Finally! A model for progesterone receptor action in normal human breast.
Endocrinology 2009;150(7):2988-90.
2008: Rodrigo Fernandez-Valdivia; Atish Mukherjee; Chad J Creighton; Adam C Buser; Francesco J DeMayo; Dean P Edwards; John P Lydon
Transcriptional response of the murine mammary gland to acute progesterone exposure.
Endocrinology 2008;149(12):6236-50.
2008: Viroj Boonyaratanakornkit; Yan Bi; Michael Rudd; Dean P Edwards
The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression.
Steroids 2008;73(9-10):922-8.
2008: Sarah C Roemer; James Adelman; Mair E A Churchill; Dean P Edwards
Mechanism of high-mobility group protein B enhancement of progesterone receptor sequence-specific DNA binding.
Nucleic acids research 2008;36(11):3655-66.
2007: Eileen Mary McGowan; Amanda J Russell; Viroj Boonyaratanakornkit; Darren Saunders; Gillian M Lehrbach; C Marcelo Sergio; Elizabeth A Musgrove; Dean P Edwards; Robert L Sutherland
Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor.
Cancer research 2007;67(18):8942-51.
2007: Romina Carnevale; Cecilia J Proietti; Mariana Salatino; Alejandro J Urtreger; Guillermo Peluffo; Dean P Edwards; Viroj Boonyaratanakornkit; Eduardo H Charreau; Elisa Bal de Kier Joffé; Roxana Schillaci; Patricia V Elizalde
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1335-58.
2007: Viroj Boonyaratanakornkit; Dean P Edwards
Receptor mechanisms mediating non-genomic actions of sex steroids.
Seminars in reproductive medicine 2007;25(3):139-53.
2007: James G Greger; Natalie Fursov; Neil Cooch; Sean McLarney; Leonard P Freedman; Dean P Edwards; Boris J Cheskis
Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.
Molecular and cellular biology 2007;27(5):1904-13.
2007: Viroj Boonyaratanakornkit; Eileen Mary McGowan; Lori Sherman; Michael A Mancini; Boris J Cheskis; Dean P Edwards
The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):359-75.
2007: Adam C Buser; Elizabeth K Gass-Handel; Shannon L Wyszomierski; Wolfgang Doppler; Susan A Leonhardt; Jerome Schaack; Jeffrey M Rosen; Harriet Watkin; Steven M Anderson; Dean P Edwards
Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):106-25.
2006: Sarah C Roemer; Douglas C Donham; Lori Sherman; Vickie H Pon; Dean P Edwards; Mair E A Churchill
Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.
Molecular endocrinology (Baltimore, Md.) 2006;20(12):3042-52.
2005: Suzanne E Wardell; Stanley C Kwok; Lori Sherman; Robert S Hodges; Dean P Edwards
Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
Molecular and cellular biology 2005;25(20):8792-808.
2005: Ramesh Narayanan; Dean P Edwards; Nancy L Weigel
Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.
Molecular and cellular biology 2005;25(8):2885-98.
2005: Suzanne E Wardell; Dean P Edwards
Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs).
Seminars in reproductive medicine 2005;23(1):9-21.
2005: Dean P Edwards
Regulation of signal transduction pathways by estrogen and progesterone.
Annual review of physiology 2005;67():335-76.
2005: Ramesh Narayanan; Abayomi A Adigun; Dean P Edwards; Nancy L Weigel
Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.
Molecular and cellular biology 2005;25(1):264-77.
2004: Irina U Agoulnik; Xiao-Wen Tong; Dagmar-C Fischer; Klaus Körner; Neely E Atkinson; Dean P Edwards; Denis R Headon; Nancy L Weigel; Dirk G Kieback
A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk.
The Journal of clinical endocrinology and metabolism 2004;89(12):6340-7.
2004: Vida Senkus Melvin; Chuck Harrell; James S Adelman; W Lee Kraus; Mair E A Churchill; Dean P Edwards
The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.
The Journal of biological chemistry 2004;279(15):14763-71.
2004: Viroj Boonyaratanakornkit; Dean P Edwards
Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormones.
Essays in biochemistry 2004;40():105-20.
2003: Susan A Leonhardt; Viroj Boonyaratanakornkit; Dean P Edwards
Progesterone receptor transcription and non-transcription signaling mechanisms.
Steroids 2003;68(10-13):761-70.
2003: Dean P Edwards; Viroj Boonyaratanakornkit
Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathway.
Molecular interventions 2003;3(1):12-5.
2002: Dean P Edwards; Suzanne E Wardell; Viroj Boonyaratanakornkit
Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):173-86.
2002: Susan A Leonhardt; Dean P Edwards
Mechanism of action of progesterone antagonists.
Experimental biology and medicine (Maywood, N.J.) 2002;227(11):969-80.
2002: Suzanne E Wardell; Viroj Boonyaratanakornkit; James S Adelman; Ami Aronheim; Dean P Edwards
Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
Molecular and cellular biology 2002;22(15):5451-66.
2002: Vida Senkus Melvin; Sarah C Roemer; Mair E A Churchill; Dean P Edwards
The C-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 co-regulatory proteins.
The Journal of biological chemistry 2002;277(28):25115-24.
2001: Viroj Boonyaratanakornkit; M P Scott; V Ribon; Lori Sherman; S M Anderson; J L Maller; W T Miller; Dean P Edwards
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.
Molecular cell 2001;8(2):269-80.
2001: T A Knotts; Ralph S Orkiszewski; Richard G Cook; Dean P Edwards; Nancy L Weigel
Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites.
The Journal of biological chemistry 2001;276(11):8475-83.
2001: Vida Senkus Melvin; Dean P Edwards
Expression and purification of recombinant human progesterone receptor in baculovirus and bacterial systems.
Methods in molecular biology (Clifton, N.J.) 2001;176():39-54.
2000: Dean P Edwards
The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors.
Journal of mammary gland biology and neoplasia 2000;5(3):307-24.
2000: Dean P Edwards; Susan A Leonhardt; E Gass-Handel
Novel mechanisms of progesterone antagonists and progesterone receptor.
Journal of the Society for Gynecologic Investigation 2000;7(1 Suppl):S22-4.
2000: D L Clemm; Lori Sherman; Viroj Boonyaratanakornkit; W T Schrader; N L Weigel; Dean P Edwards
Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody.
Molecular endocrinology (Baltimore, Md.) 2000;14(1):52-65.
1999: L V Nazareth; David L Stenoien; William E Bingman; A J James; C Wu; Y Zhang; Dean P Edwards; M Mancini; Marco Marcelli; Dolores J Lamb; Nancy L Weigel
A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1)
Molecular endocrinology (Baltimore, Md.) 1999;13(12):2065-75.
1999: J L O'Conner; Marlene F Wade; Dean P Edwards; Virendra B Mahesh
Progesterone and regulation of the follicle-stimulating hormone (FSH-beta) gene.
Steroids 1999;64(9):592-7.
1999: Vida Senkus Melvin; Dean P Edwards
Coregulatory proteins in steroid hormone receptor action: the role of chromatin high mobility group proteins HMG-1 and -2.
Steroids 1999;64(9):576-86.
1999: M J Tetel; P H Giangrande; Susan A Leonhardt; D P McDonnell; Dean P Edwards
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.
Molecular endocrinology (Baltimore, Md.) 1999;13(6):910-24.
1999: Dean P Edwards
Coregulatory proteins in nuclear hormone receptor action.
Vitamins and hormones 1999;55():165-218.
1998: Susan A Leonhardt; M Altmann; Dean P Edwards
Agonist and antagonists induce homodimerization and mixed ligand heterodimerization of human progesterone receptors in vivo by a mammalian two-hybrid assay.
Molecular endocrinology (Baltimore, Md.) 1998;12(12):1914-30.
1998: Viroj Boonyaratanakornkit; V Melvin; P Prendergast; M Altmann; Lorenza Ronfani; Marco E Bianchi; L Taraseviciene; Steven K Nordeen; E A Allegretto; Dean P Edwards
High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.
Molecular and cellular biology 1998;18(8):4471-87.
1998: Sergio A Onate; Viroj Boonyaratanakornkit; TE Spencer; Sophia Y Tsai; Ming-Jer Tsai; Dean P Edwards; Bert W O'Malley
The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.
The Journal of biological chemistry 1998;273(20):12101-8.
1998: E K Gass; Susan A Leonhardt; Steven K Nordeen; Dean P Edwards
The antagonists RU486 and ZK98299 stimulate progesterone receptor binding to deoxyribonucleic acid in vitro and in vivo, but have distinct effects on receptor conformation.
Endocrinology 1998;139(4):1905-19.
1997: J L O'Conner; Marlene F Wade; P Prendergast; Dean P Edwards; Viroj Boonyaratanakornkit; Virendra B Mahesh
A 361 base pair region of the rat FSH-beta promoter contains multiple progesterone receptor-binding sequences and confers progesterone responsiveness.
Molecular and cellular endocrinology 1997;136(1):67-78.
1997: M J Tetel; S Jung; P Carbajo; T Ladtkow; Debra F Skafar; Dean P Edwards
Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1114-28.
1997: Y Zhang; C A Beck; A Poletti; JP Clement; P Prendergast; T T Yip; T William Hutchens; Dean P Edwards; Nancy L Weigel
Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):823-32.
1996: C A Beck; Y Zhang; M Altmann; Nancy L Weigel; Dean P Edwards
Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system.
The Journal of biological chemistry 1996;271(32):19546-55.
1996: P Carbajo; K Christensen; Dean P Edwards; Debra F Skafar
Binding of [3H]progesterone to the human progesterone receptor: differences between individual and mixed isoforms.
Endocrinology 1996;137(6):2339-46.
1996: P Prendergast; Z Pan; Dean P Edwards
Progesterone receptor-induced bending of its target DNA: distinct effects of the A and B receptor forms.
Molecular endocrinology (Baltimore, Md.) 1996;10(4):393-407.
1996: Jadwiga K Kepa; B M Jacobsen; E A Boen; P Prendergast; Dean P Edwards; Glenn S Takimoto; Margaret E Wierman
Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH.
Molecular and cellular endocrinology 1996;117(1):27-39.
1996: C A Beck; Y Zhang; Nancy L Weigel; Dean P Edwards
Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor.
The Journal of biological chemistry 1996;271(2):1209-17.
1995: Y Zhang; C A Beck; A Poletti; Dean P Edwards; Nancy L Weigel
Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1995;9(8):1029-40.
1995: Nancy L Weigel; W Bai; Y Zhang; C A Beck; Dean P Edwards; A Poletti
Phosphorylation and progesterone receptor function.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):509-14.
1995: Dean P Edwards; M Altmann; Angelo M DeMarzo; Y Zhang; Nancy L Weigel; C A Beck
Progesterone receptor and the mechanism of action of progesterone antagonists.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):449-58.
1995: Steven K Nordeen; B J Bona; C A Beck; Dean P Edwards; K C Borror; Donald B DeFranco
The two faces of a steroid antagonist: when an antagonist isn't.
Steroids 1995;60(1):97-104.
1994: Y Zhang; C A Beck; A Poletti; Dean P Edwards; Nancy L Weigel
Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.
The Journal of biological chemistry 1994;269(49):31034-40.
1994: Sergio A Onate; P Prendergast; J P Wagner; M Nissen; R Reeves; D E Pettijohn; Dean P Edwards
The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences.
Molecular and cellular biology 1994;14(5):3376-91.
1994: P Prendergast; Sergio A Onate; K Christensen; Dean P Edwards
Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA.
The Journal of steroid biochemistry and molecular biology 1994;48(1):1-13.
1993: C A Beck; P A Estes; B J Bona; C A Muro-Cacho; Steven K Nordeen; Dean P Edwards
The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors.
Endocrinology 1993;133(2):728-40.
1993: C A Beck; Nancy L Weigel; M L Moyer; Steven K Nordeen; Dean P Edwards
The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4441-5.
1993: B A Lieberman; B J Bona; Dean P Edwards; Steven K Nordeen
The constitution of a progesterone response element.
Molecular endocrinology (Baltimore, Md.) 1993;7(4):515-27.
1993: Dean P Edwards; Nancy L Weigel; Steven K Nordeen; C A Beck
Modulators of cellular protein phosphorylation alter the trans-activation function of human progesterone receptor and the biological activity of progesterone antagonists.
Breast cancer research and treatment 1993;27(1-2):41-56.
1992: Angelo M DeMarzo; Sergio A Onate; Steven K Nordeen; Dean P Edwards
Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor.
Biochemistry 1992;31(43):10491-501.
1992: Nancy L Weigel; C A Beck; P A Estes; P Prendergast; M Altmann; K Christensen; Dean P Edwards
Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1585-97.
1992: G F Allan; X Leng; Sophia Y Tsai; Nancy L Weigel; Dean P Edwards; Ming-Jer Tsai; Bert W O'Malley
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.
The Journal of biological chemistry 1992;267(27):19513-20.
1992: C A Beck; Nancy L Weigel; Dean P Edwards
Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors.
Molecular endocrinology (Baltimore, Md.) 1992;6(4):607-20.
1992: Dean P Edwards; P A Estes; V A Fadok; B J Bona; Sergio A Onate; Steven K Nordeen; W J Welch
Heat shock alters the composition of heteromeric steroid receptor complexes and enhances receptor activity in vivo.
Biochemistry 1992;31(9):2482-91.
1991: Sergio A Onate; P A Estes; W J Welch; Steven K Nordeen; Dean P Edwards
Evidence that heat shock protein-70 associated with progesterone receptors is not involved in receptor-DNA binding.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1993-2004.
1991: K Christensen; P A Estes; Sergio A Onate; C A Beck; Angelo M DeMarzo; M Altmann; B A Lieberman; J St John; Steven K Nordeen; Dean P Edwards
Characterization and functional properties of the A and B forms of human progesterone receptors synthesized in a baculovirus system.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1755-70.
1991: Dean P Edwards; Angelo M DeMarzo; Sergio A Onate; C A Beck; P A Estes; Steven K Nordeen
Mechanisms controlling steroid receptor binding to specific DNA sequences.
Steroids 1991;56(5):271-8.
1991: Angelo M DeMarzo; C A Beck; Sergio A Onate; Dean P Edwards
Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):72-6.
1989: B Kühnel; Dorraya El-Ashry; Dean P Edwards; Steven K Nordeen
Mapping contacts between unpurified human progesterone receptor and the hormone response element of mouse mammary tumor virus.
DNA (Mary Ann Liebert, Inc.) 1989;8(10):703-13.
1989: Dorraya El-Ashry; Sergio A Onate; Steven K Nordeen; Dean P Edwards
Human progesterone receptor complexed with the antagonist RU 486 binds to hormone response elements in a structurally altered form.
Molecular endocrinology (Baltimore, Md.) 1989;3(10):1545-58.
1989: Steven K Nordeen; B Kühnel; J Lawler-Heavner; D A Barber; Dean P Edwards
A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell line.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1270-8.
1989: Dean P Edwards; B Kühnel; P A Estes; Steven K Nordeen
Human progesterone receptor binding to mouse mammary tumor virus deoxyribonucleic acid: dependence on hormone and nonreceptor nuclear factor(s).
Molecular endocrinology (Baltimore, Md.) 1989;3(2):381-91.
1988: M K Bagchi; J F Elliston; Sophia Y Tsai; Dean P Edwards; Ming-Jer Tsai; Bert W O'Malley
Steroid hormone-dependent interaction of human progesterone receptor with its target enhancer element.
Molecular endocrinology (Baltimore, Md.) 1988;2(12):1221-9.
1988: D Elashry-Stowers; D T Zava; W C Speers; Dean P Edwards
Immunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.
Cancer research 1988;48(22):6462-74.
1987: LL Wei; P L Sheridan; N L Krett; M D Francis; David O Toft; Dean P Edwards; Kathryn B Horwitz
Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing.
Biochemistry 1987;26(19):6262-72.
1987: P A Estes; E J Suba; J Lawler-Heavner; D Elashry-Stowers; LL Wei; David O Toft; William P Sullivan; Kathryn B Horwitz; Dean P Edwards
Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies.
Biochemistry 1987;26(19):6250-62.