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Dylan Edwards

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Suvi-Katri Leivonen; Konstantinos Lazaridis; Andrew Chantry; Julie Decock; Dylan R Edwards; Veli-Matti Kähäri
TGF-β-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38α, and ERK1/2.
J P Baren; D A C Deans; Dylan R Edwards; K C H Fearon; K Gray; R O'Neill; Simon Paterson-Brown; Caroline J Pennington; Antony C P Riddick; James A Ross; Grant Stewart; A Stokes; Richard J E Skipworth
mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.
Lindsay S Cooley; Dylan R Edwards
New insights into the plasticity of the endothelial phenotype.

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2013: Suvi-Katri Leivonen; Konstantinos Lazaridis; Andrew Chantry; Julie Decock; Dylan R Edwards; Veli-Matti Kähäri
TGF-β-elicited induction of tissue inhibitor of metalloproteinases (TIMP)-3 expression in fibroblasts involves complex interplay between Smad3, p38α, and ERK1/2.
PloS one 2013;8(2):e57474.
2012: J P Baren; D A C Deans; Dylan R Edwards; K C H Fearon; K Gray; R O'Neill; Simon Paterson-Brown; Caroline J Pennington; Antony C P Riddick; James A Ross; Grant Stewart; A Stokes; Richard J E Skipworth
mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.
British journal of cancer 2012;107(1):143-9.
2011: Lindsay S Cooley; Dylan R Edwards
New insights into the plasticity of the endothelial phenotype.
Biochemical Society transactions 2011;39(6):1639-43.
2011: Julie Decock; Sally Thirkettle; Laura Wagstaff; Dylan R Edwards
Matrix metalloproteinases: protective roles in cancer.
Journal of cellular and molecular medicine 2011;15(6):1254-65.
2011: Tanya Stuchinskaya; Miguel Moreno; Michael J Cook; Dylan R Edwards; David A Russell
Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011;10(5):822-31.
2011: Laura Wagstaff; Richard Kelwick; Julie Decock; Dylan R Edwards
The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis.
Frontiers in bioscience : a journal and virtual library 2011;16():1861-72.
2010: Lorna Ravenhill; Laura Wagstaff; Dylan R Edwards; Vincent Ellis; Rosemary Bass
G-helix of maspin mediates effects on cell migration and adhesion.
The Journal of biological chemistry 2010;285(47):36285-92.
2010: Lindsay S Cooley; Madeleine M Handsley; Zhigang Zhou; Marc A Lafleur; Caroline J Pennington; Erik W Thompson; Ernst Pöschl; Dylan R Edwards
Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro.
Journal of cell science 2010;123(Pt 21):3808-16.
2010: Jennifer M Atkinson; Robert A Falconer; Dylan R Edwards; Caroline J Pennington; Catherine S Siller; Steven D Shnyder; Michael C Bibby; Laurence H Patterson; Paul M Loadman; Jason H Gill
Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.
Cancer research 2010;70(17):6902-12.
2010: Rosemary Bass; Dylan R Edwards
ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?
The Biochemical journal 2010;428(3):e3-5.
2010: Justin A Green; Paul T Elkington; Caroline J Pennington; Federico Roncaroli; Shruti Dholakia; Rachel C Moores; Anwen Bullen; Joanna C Porter; Dan Agranoff; Dylan R Edwards; Jon S Friedland
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6492-503.
2010: Angela Stokes; Juho Joutsa; Risto Ala-Aho; Mark Pitchers; Caroline J Pennington; Craig Martin; Don J Premachandra; Yasunori Okada; Juha Peltonen; Reidar Grénman; Helen A James; Dylan R Edwards; Veli-Matti Kähäri
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(7):2022-35.
2010: Lisa M Hodgkinson; Lixin Wang; George Duncan; Dylan R Edwards; I Michael Wormstone
ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells.
Molecular vision 2010;16():2765-76.
2010: Caroline J Pennington; Dylan R Edwards
Real-time PCR expression profiling of MMPs and TIMPs.
Methods in molecular biology (Clifton, N.J.) 2010;622():159-73.
2010: Achim Krüger; Ronald E Kates; Dylan R Edwards
Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition.
Biochimica et biophysica acta 2010;1803(1):95-102.
2009: Amanda J Harvey; Caroline J Pennington; Sarah Porter; Rajpal S Burmi; Dylan R Edwards; William Court; Suzanne A Eccles; Mark R Crompton
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.
The American journal of pathology 2009;175(3):1226-34.
2009: Andrew D Frutkin; Goro Otsuka; April Stempien-Otero; Casilde Sesti; Liang Du; Mia Jaffe; Helén L Dichek; Caroline J Pennington; Dylan R Edwards; Madeline Nieves-Cintrón; Daniel Minter; Michael Preusch; Jie Hong Hu; Julien C Marie; David A Dichek
TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1251-7.
2009: Thorsten Maretzky; Sylvain M Le Gall; Susanne Worpenberg-Pietruk; Jörg Eder; Christopher M Overall; Xin-Yun Huang; Zaruhi Poghosyan; Dylan R Edwards; Carl P Blobel
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.
Cancer research 2009;69(11):4573-6.
2009: Rachael A Hancox; Michael D Allen; Deborah L Holliday; Dylan R Edwards; Caroline J Pennington; David S Guttery; Jacqueline A Shaw; Rosemary A Walker; James Pringle; J Louise Jones
Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms.
Breast cancer research : BCR 2009;11(2):R24.
2009: Philippe Boutet; Sonia Agüera-González; Susan Atkinson; Caroline J Pennington; Dylan R Edwards; Gillian Murphy; Hugh Reyburn; Mar Valés-Gómez
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):49-53.
2008: Grant D Stewart; Kelly Gray; Caroline J Pennington; Dylan R Edwards; Antony C P Riddick; James A Ross; Fouad K Habib
Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score.
Oncology reports 2008;20(6):1561-7.
2008: Dylan R Edwards; Madeleine M Handsley; Caroline J Pennington
The ADAM metalloproteinases.
Molecular aspects of medicine 2008;29(5):258-89.
2008: Grant Stewart; Richard J E Skipworth; Caroline J Pennington; Alastair G Lowrie; D A C Deans; Dylan R Edwards; Fouad K Habib; Antony C P Riddick; Kenneth C H Fearon; James A Ross
Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines.
British journal of cancer 2008;99(1):126-32.
2008: Ana Gutiérrez-Fernández; Antonio Fueyo; Alicia R Folgueras; Cecilia Garabaya; Caroline J Pennington; Simon Pilgrim; Dylan R Edwards; Deborah L Holliday; J Louise Jones; Paul Span; Fred C G J Sweep; Xose S Puente; Carlos López-Otín
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Cancer research 2008;68(8):2755-63.
2008: Alicia R Folgueras; Antonio Fueyo; Olivia García-Suárez; Jennifer Cox; AURORA ASTUDILLO; Paolo Tortorella; Cristina Campestre; Ana Gutiérrez-Fernández; Miriam Fanjul-Fernández; Caroline J Pennington; Dylan R Edwards; Christopher M Overall; Carlos López-Otín
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
The Journal of biological chemistry 2008;283(14):9465-74.
2008: Michael Gerg; Charlotte Kopitz; Susanne Schaten; Alexander Tschukes; Christoph Kahlert; Manfred Stangl; Claus W Hann von Weyhern; Björn L.D.M. Brücher; Dylan R Edwards; Karsten Brand; Achim Krüger
Distinct functionality of tumor cell-derived gelatinases during formation of liver metastases.
Molecular cancer research : MCR 2008;6(3):341-51.
2008: Julia L Zhong; Zaruhi Poghosyan; Caroline J Pennington; Xanthe Scott; Madeleine M Handsley; A Warn; Jelena Gavrilovic; Katja Honert; Achim Krüger; Paul Span; Fred C G J Sweep; Dylan R Edwards
Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.
Molecular cancer research : MCR 2008;6(3):383-94.
2008: Chitranjan J Shukla; Caroline J Pennington; Antony C P Riddick; Krishna K Sethia; Richard Y Ball; Dylan R Edwards
Laser-capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour-stroma interactions.
BJU international 2008;101(6):765-74.
2008: Clara L Sampieri; Robert K Nuttall; David A Young; Deborah Goldspink; Ian Clark; Dylan R Edwards
Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(2):128-38.
2008: Boye Nielsen; Mikala Egeblad; Fritz Rank; Hanne A Askautrud; Caroline J Pennington; Tanja X Pedersen; Ib J Christensen; Dylan R Edwards; Zena Werb; Leif R Lund
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
PloS one 2008;3(8):e2959.
2008: Ian Clark; Tracey E Swingler; Clara L Sampieri; Dylan R Edwards
The regulation of matrix metalloproteinases and their inhibitors.
The international journal of biochemistry & cell biology 2008;40(6-7):1362-78.
2007: Charlotte Kopitz; Michael Gerg; Obul Reddy Bandapalli; Dilek Ister; Caroline Pennington; Stephanie Hauser; Christin Flechsig; Hans-Willi Krell; Dalibor Antolovic; Keith Brew; Hideaki Nagase; Manfred Stangl; Claus W Hann von Weyhern; Björn L.D.M. Brücher; Karsten Brand; Lisa M Coussens; Dylan R Edwards; Achim Krüger
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.
Cancer research 2007;67(18):8615-23.
2007: Lisa M Hodgkinson; George Duncan; Lixin Wang; Caroline J Pennington; Dylan R Edwards; I Michael Wormstone
MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells.
Investigative ophthalmology & visual science 2007;48(9):4192-9.
2007: Harcharan K Rooprai; Ioannis Kyriazis; Robert K Nuttall; Dylan R Edwards; Daniel Zicha; Deborah Aubyn; Derek Davies; Richard Gullan; Geoffrey J Pilkington
Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro.
International journal of oncology 2007;30(5):1263-71.
2007: Robert K Nuttall; Claudia Silva; Walter J Hader; Amit Bar-Or; Kamala D Patel; Dylan R Edwards; V Wee Yong
Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia.
Glia 2007;55(5):516-26.
2007: James E Harris; Robert K Nuttall; Paul T Elkington; Justin A Green; Donna E Horncastle; Manuel B Graeber; Dylan R Edwards; Jon S Friedland
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):1199-207.
2006: Susobhan Sarkar; Robert K Nuttall; Shuhong Liu; Dylan R Edwards; V Wee Yong
Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.
Cancer research 2006;66(24):11771-80.
2006: M Pitchers; A Stokes; R Lonsdale; D J Premachandra; Dylan R Edwards
Research tissue banking in otolaryngology: organization, methods and uses, with reference to practical, ethical and legal issues.
The Journal of laryngology and otology 2006;120(6):433-8.
2006: Vincent Chabottaux; Nor Eddine SOUNNI; Caroline J Pennington; William R English; Frédéric van den Brûle; Silvia Blacher; Christine Gilles; Carine Munaut; Erik Maquoi; Carlos Lopez-Otin; Gillian Murphy; Dylan R Edwards; Jean-Michel Foidart; Agnès Noël
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Cancer research 2006;66(10):5165-72.
2006: Jorge García-Alvarez; Remedios Ramirez; Marco Checa; Robert K Nuttall; Clara L Sampieri; Dylan R Edwards; Moisés Selman; Annie Pardo
Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.
Experimental lung research 2006;32(5):201-14.
2006: Jorge García-Alvarez; Remedios Ramirez; Clara L Sampieri; Robert K Nuttall; Dylan R Edwards; Moisés Selman; Annie Pardo
Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2006;23(1):13-21.
2006: Gavin C Jones; Anthony N Corps; Caroline J Pennington; Ian Clark; Dylan R Edwards; Michelle M Bradley; Brian L Hazleman; Graham P Riley
Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.
Arthritis and rheumatism 2006;54(3):832-42.
2006: Sarah Porter; Paul Span; Fred C G J Sweep; Vivianne C G Tjan-Heijnen; Caroline J Pennington; Tanja Xenia Pedersen; Morten Johnsen; Leif R Lund; John Rømer; Dylan R Edwards
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
International journal of cancer. Journal international du cancer 2006;118(5):1241-7.
2005: Paul T Elkington; Robert K Nuttall; Joseph J Boyle; Cecilia M O'Kane; Donna E Horncastle; Dylan R Edwards; Jon S Friedland
Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.
American journal of respiratory and critical care medicine 2005;172(12):1596-604.
2005: Andrew Weaver; Angelika Goncalves da Silva; Robert K Nuttall; Dylan R Edwards; Steven D Shapiro; Serge Rivest; V Wee Yong
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1668-70.
2005: Zamaneh Kassiri; Gavin Y Oudit; Otto H Sanchez; Fayez Dawood; Fazilat F Mohammed; Robert K Nuttall; Dylan R Edwards; Peter P Liu; Peter H Backx; Rama Khokha
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Circulation research 2005;97(4):380-90.
2005: Madeleine M Handsley; Dylan R Edwards
Metalloproteinases and their inhibitors in tumor angiogenesis.
International journal of cancer. Journal international du cancer 2005;115(6):849-60.
2005: Robert J R Singh; Justin C Mason; Elaine A Lidington; Dylan R Edwards; Robert K Nuttall; Rama Khokha; Vera Knauper; Gillian Murphy; Jelena Gavrilovic
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Cardiovascular research 2005;67(1):39-49.
2005: Tanja Xenia Pedersen; Caroline J Pennington; Kasper Almholt; Ib Jarle Christensen; Boye Nielsen; Dylan R Edwards; John Rømer; Keld Danø; Morten Johnsen
Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.
Carcinogenesis 2005;26(7):1233-40.
2005: Antony C P Riddick; C J Shukla; Caroline J Pennington; Rosemary Bass; Robert K Nuttall; Aileen Hogan; Krishna K Sethia; Vincent Ellis; Anne T Collins; Norman J Maitland; Richard Y Ball; Dylan R Edwards
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.
British journal of cancer 2005;92(12):2171-80.
2005: Christopher P Denton; Gisela E Lindahl; Korsa Khan; Xu Shiwen; Voon H Ong; Nicholas J Gaspar; Konstantinos Lazaridis; Dylan R Edwards; Andrew Leask; Mark Eastwood; Patricia Leoni; Elisabetta A Renzoni; George Bou-Gharios; David J Abraham; Carol M Black
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
The Journal of biological chemistry 2005;280(16):16053-65.
2005: David A Young; Olivia Billingham; Clara L Sampieri; Dylan R Edwards; Ian Clark
Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression.
The FEBS journal 2005;272(8):1912-26.
2005: Fazilat F Mohammed; Caroline J Pennington; Zamaneh Kassiri; Jeffrey S Rubin; Paul D Soloway; Ulrich Ruther; Dylan R Edwards; Rama Khokha
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(4):857-67.
2005: Sarah Porter; Ian Clark; Lara Kevorkian; Dylan R Edwards
The ADAMTS metalloproteinases.
The Biochemical journal 2005;386(Pt 1):15-27.
2005: David A Young; Rachel L Lakey; Caroline J Pennington; Debra Jones; Lara Kevorkian; Dylan R Edwards; Tim E Cawston; Ian Clark
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Arthritis research & therapy 2005;7(3):R503-12.
2004: Henrik Toft-Hansen; Robert K Nuttall; Dylan R Edwards; Trevor Owens
Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5209-18.
2004: David A Young; Svetlana Gavrilov; Caroline J Pennington; Robert K Nuttall; Dylan R Edwards; Richard N Kitsis; Ian Clark
Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes.
Biochemical and biophysical research communications 2004;322(3):759-65.
2004: Robert K Nuttall; Clara L Sampieri; Caroline J Pennington; Sean E Gill; Gilbert A Schultz; Dylan R Edwards
Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.
FEBS letters 2004;563(1-3):129-34.
2004: Dylan R Edwards
TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges.
The Journal of pathology 2004;202(4):391-4.
2004: Sarah Porter; Stuart D Scott; Elaine M Sassoon; Mark R Williams; J Louise Jones; Anne C Girling; Richard Y Ball; Dylan R Edwards
Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2429-40.
2004: Lara Kevorkian; David A Young; Clare Darrah; Simon T Donell; Lee Shepstone; Sarah Porter; Sarah M V Brockbank; Dylan R Edwards; Andrew E Parker; Ian Clark
Expression profiling of metalloproteinases and their inhibitors in cartilage.
Arthritis and rheumatism 2004;50(1):131-41.
2003: Joanna R Worley; Mark D Baugh; David A Hughes; Dylan R Edwards; Aileen Hogan; Mike J Sampson; Jelena Gavrilovic
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
The Journal of biological chemistry 2003;278(51):51340-6.
2003: Roger A Moorehead; Carlo V Hojilla; Ian De Belle; Geoffrey A Wood; Jimmie E Fata; Eileen D Adamson; Katrina L M Watson; Dylan R Edwards; Rama Khokha
Insulin-like growth factor-II regulates PTEN expression in the mammary gland.
The Journal of biological chemistry 2003;278(50):50422-7.
2003: Amit Bar-Or; Robert K Nuttall; Martin Duddy; Andrea Alter; Ho Jin Kim; Igal Ifergan; Caroline J Pennington; Pierre Bourgoin; Dylan R Edwards; V Wee Yong
Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.
Brain : a journal of neurology 2003;126(Pt 12):2738-49.
2003: Jennifer Elizabeth Ann Larsen; Tiffany K Rice; Robert K Nuttall; Dylan R Edwards; Hakima Zekki; Serge Rivest; V Wee Yong
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(31):10107-15.
2003: C I Platt; CA Krekoski; R V Ward; Dylan R Edwards; Jelena Gavrilovic
Extracellular matrix and matrix metalloproteinases in sciatic nerve.
Journal of neuroscience research 2003;74(3):417-29.
2003: Ingo J Banke; Matthias J E Arlt; Caroline Pennington; Charlotte Kopitz; Torsten Steinmetzer; Andrea Schweinitz; Bernd Gansbacher; James P Quigley; Dylan R Edwards; Jörg Stürzebecher; Achim Krüger
Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.
Biological chemistry 2003;384(10-11):1515-25.
2003: Marc A Lafleur; Madeleine M Handsley; Dylan R Edwards
Metalloproteinases and their inhibitors in angiogenesis.
Expert reviews in molecular medicine 2003;5(23):1-39.
2003: Joanna R Worley; Philip B Thompkins; Meng H Lee; Mike Hutton; Paul Soloway; Dylan R Edwards; Gillian Murphy; Vera Knäuper
Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).
The Biochemical journal 2003;372(Pt 3):799-809.
2003: Andrea Alter; Martin Duddy; Sherry Hebert; Katarzyna Biernacki; Alexandre Prat; Jack P Antel; V Wee Yong; Robert K Nuttall; Caroline J Pennington; Dylan R Edwards; Amit Bar-Or
Determinants of human B cell migration across brain endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4497-505.
2003: Heidi Palosaari; Caroline J Pennington; Markku Larmas; Dylan R Edwards; Leo Tjäderhane; Tuula Salo
Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue.
European journal of oral sciences 2003;111(2):117-27.
2003: Marie-Claire Hall; David A Young; Jasmine G Waters; Andrew D Rowan; Andrew Chantry; Dylan R Edwards; Ian Clark
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.
The Journal of biological chemistry 2003;278(12):10304-13.
2003: Robert K Nuttall; Caroline J Pennington; Jennifer Taplin; Alison Wheal; V Wee Yong; Peter A Forsyth; Dylan R Edwards
Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells.
Molecular cancer research : MCR 2003;1(5):333-45.
2003: Antony C P Riddick; C Barker; I Sheriffs; Rosemary Bass; Vincent Ellis; Krishna K Sethia; Dylan R Edwards; Richard Y Ball
Banking of fresh-frozen prostate tissue: methods, validation and use.
BJU international 2003;91(4):315-23; discussion 323-4.
2002: Léon C L van Kempen; Jin-Sae Rhee; Kerstin Dehne; Jake Lee; Dylan R Edwards; Lisa M Coussens
Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment.
Differentiation; research in biological diversity 2002;70(9-10):610-23.
2002: Anna Radomski; Paul Jurasz; Esmond J Sanders; Christopher M Overall; Heather F Bigg; Dylan R Edwards; Marek W Radomski
Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets.
British journal of pharmacology 2002;137(8):1330-8.
2002: M-C Hall; David A Young; Andrew D Rowan; Dylan R Edwards; Ian Clark
Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors.
BioTechniques 2002;33(5):1004, 1006, 1008.
2002: Jo S Price; Jasmine G Waters; Clare Darrah; Caroline J Pennington; Dylan R Edwards; Simon T Donell; Ian Clark
The role of chondrocyte senescence in osteoarthritis.
Aging cell 2002;1(1):57-65.
2002: Matthias J E Arlt; Charlotte Kopitz; Caroline Pennington; Katrina L M Watson; Hans-Willi Krell; Wolfram Bode; Bernd Gansbacher; Rama Khokha; Dylan R Edwards; Achim Krüger
Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.
Cancer research 2002;62(19):5543-50.
2002: Andrew H Baker; Dylan R Edwards; Gillian Murphy
Metalloproteinase inhibitors: biological actions and therapeutic opportunities.
Journal of cell science 2002;115(Pt 19):3719-27.
2002: Marc A Lafleur; Madeleine M Handsley; Vera Knäuper; Gillian Murphy; Dylan R Edwards
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).
Journal of cell science 2002;115(Pt 17):3427-38.
2002: Steven J Wall; Damon Bevan; David W Thomas; Keith G Harding; Dylan R Edwards; Gillian Murphy
Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse.
The Journal of investigative dermatology 2002;119(1):91-8.
2002: David A Young; Blaine W Phillips; Caroline Lundy; Robert K Nuttall; Aileen Hogan; Gilbert A Schultz; Kevin J Leco; Ian Clark; Dylan R Edwards
Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.
The Biochemical journal 2002;364(Pt 1):89-99.
2002: Jian Hua Qi; Quteba Ebrahem; Karen Yeow; Dylan R Edwards; Paul L Fox; Bela Anand-Apte
Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.
The Journal of biological chemistry 2002;277(16):13394-400.
2002: Paul Koshy; Caroline Lundy; Andrew D Rowan; S Porter; Dylan R Edwards; A Hogan; Ian Clark; Tim E Cawston
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
Arthritis and rheumatism 2002;46(4):961-7.
2002: Jae-Chang Jung; Kevin J Leco; Dylan R Edwards; M Elizabeth Fini
Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;223(3):402-13.
2002: Zaruhi Poghosyan; Stephen M Robbins; Miles D Houslay; Ailsa Webster; Gillian Murphy; Dylan R Edwards
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The Journal of biological chemistry 2002;277(7):4999-5007.
2002: Steven J Wall; Dylan R Edwards
Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs.
Analytical biochemistry 2002;300(2):269-73.
2002: Karen M Yeow; Narendra S Kishnani; Mike Hutton; Susan P Hawkes; Gillian Murphy; Dylan R Edwards
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(1):75-88.
2001: M Maillard; Bruno CADOT; Richard Y Ball; Krishna K Sethia; Dylan R Edwards; B Perbal; Roger Tatoud
Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.
Molecular pathology : MP 2001;54(4):275-80.
2001: L L Groft; Huong Muzik; N Barry Rewcastle; Randal Johnston; Vera Knäuper; Marc A Lafleur; Peter A Forsyth; Dylan R Edwards
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas.
British journal of cancer 2001;85(1):55-63.
2001: V Wee Yong; Christopher Power; P Forsyth; Dylan R Edwards
Metalloproteinases in biology and pathology of the nervous system.
Nature reviews. Neuroscience 2001;2(7):502-11.
2001: Marc A Lafleur; M D Hollenberg; Susan J Atkinson; Vera Knäuper; Gillian Murphy; Dylan R Edwards
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.
The Biochemical journal 2001;357(Pt 1):107-15.
2001: Eliza J Whiteside; M M Jackson; Adrian C Herington; Dylan R Edwards; Mark B Harvey
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos.
Biology of reproduction 2001;64(5):1331-7.
2001: Marc A Lafleur; Peter A Forsyth; Susan J Atkinson; Gillian Murphy; Dylan R Edwards
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity.
Biochemical and biophysical research communications 2001;282(2):463-73.
2001: H Wong; Huong Muzik; L L Groft; Marc A Lafleur; C Matouk; Peter A Forsyth; G A Schultz; S J Wall; Dylan R Edwards
Monitoring MMP and TIMP mRNA expression by RT-PCR.
Methods in molecular biology (Clifton, N.J.) 2001;151():305-20.
2001: K M Yeow; Blaine W Phillips; P P Beaudry; Kevin J Leco; G Murphy; Dylan R Edwards
Expression of MMPs and TIMPs in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2001;151():181-9.
2000: P Harvey; Ian Clark; M C Jaurand; Richard Warn; Dylan R Edwards
Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases.
British journal of cancer 2000;83(9):1147-53.
2000: G Dean; David A Young; Dylan R Edwards; Ian Clark
The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1.
The Journal of biological chemistry 2000;275(42):32664-71.
2000: S A Raithatha; Huong Muzik; H Muzik; N Barry Rewcastle; Randal Johnston; Dylan R Edwards; Peter A Forsyth
Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas.
Neuro-oncology 2000;2(3):145-50.
1999: LY Oh; Peter H Larsen; CA Krekoski; Dylan R Edwards; F Donovan; Z Werb; V Wee Yong
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8464-75.
1999: Anna E Kossakowska; Dylan R Edwards; Chris Prusinkiewicz; M C Zhang; D Guo; Stefan J Urbanski; T Grogan; Leah Marquez; Anna Janowska-Wieczorek
Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.
Blood 1999;94(6):2080-9.
1999: Blaine W Phillips; R Sharma; P A Leco; Dylan R Edwards
A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene.
The Journal of biological chemistry 1999;274(32):22197-207.
1999: Anna E Kossakowska; Shaun A C Medlicott; Dylan R Edwards; Lindsay Guyn; AL Stabbler; L R Sutherland; Stefan J Urbanski
Elevated plasma gelatinase A (MMP-2) activity is associated with quiescent Crohn's Disease.
Annals of the New York Academy of Sciences 1999;878():578-80.
1999: Anna Janowska-Wieczorek; Leah Marquez; Jean-Marc Nabholtz; M L Cabuhat; J Montaño; H Chang; J Rozmus; J A Russell; Dylan R Edwards; A Robert Turner
Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane.
Blood 1999;93(10):3379-90.
1999: Anna Janowska-Wieczorek; Leah Marquez; A Matsuzaki; H R Hashmi; Loree Larratt; Lynn K Boshkov; A Robert Turner; M C Zhang; Dylan R Edwards; Anna E Kossakowska
Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells.
British journal of haematology 1999;105(2):402-11.
1999: Peter A Forsyth; H Wong; T D Laing; N Barry Rewcastle; Donald G Morris; Huong Muzik; K J Leco; Randal Johnston; P M A Brasher; Garnette R Sutherland; Dylan R Edwards
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
British journal of cancer 1999;79(11-12):1828-35.
1999: P Frölichsthal-Schoeller; Angelo L Vescovi; CA Krekoski; G Murphy; Dylan R Edwards; Peter A Forsyth
Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem cells.
Neuroreport 1999;10(2):345-51.
1998: Anna E Kossakowska; Dylan R Edwards; Samuel S Lee; L S Urbanski; AL Stabbler; C L Zhang; Blaine W Phillips; Yikun Zhang; Stefan J Urbanski
Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis.
The American journal of pathology 1998;153(6):1895-902.
1998: V Wee Yong; CA Krekoski; Peter A Forsyth; R Bell; Dylan R Edwards
Matrix metalloproteinases and diseases of the CNS.
Trends in neurosciences 1998;21(2):75-80.
1998: Anna E Kossakowska; A Hinek; Dylan R Edwards; Megan S Lim; C L Zhang; DR Breitman; Chris Prusinkiewicz; AL Stabbler; L S Urbanski; Stefan J Urbanski
Proteolytic activity of human non-Hodgkin's lymphomas.
The American journal of pathology 1998;152(2):565-76.
1998: Peter A Forsyth; T D Laing; A W Gibson; N Barry Rewcastle; P M A Brasher; Garnette R Sutherland; Randal Johnston; Dylan R Edwards
High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma.
Journal of neuro-oncology 1998;36(1):21-9.
1997: Arthur W Clark; CA Krekoski; SS Bou; K R Chapman; Dylan R Edwards
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia.
Neuroscience letters 1997;238(1-2):53-6.
1997: Ian Clark; Andrew D Rowan; Dylan R Edwards; T Bech-Hansen; Derek A Mann; M J Bahr; Tim E Cawston
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.
The Biochemical journal 1997;324 ( Pt 2)():611-7.
1997: Kevin J Leco; S S Apte; G T Taniguchi; S P Hawkes; Rama Khokha; Gilbert A Schultz; Dylan R Edwards
Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues.
FEBS letters 1997;401(2-3):213-7.
1997: Kevin J Leco; Mark B Harvey; Aileen Hogan; N G Copeland; D J Gilbert; N A Jenkins; Dylan R Edwards; Gilbert A Schultz
Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse.
Developmental genetics 1997;21(1):55-60.
1997: Gilbert A Schultz; Dylan R Edwards
Biology and genetics of implantation.
Developmental genetics 1997;21(1):1-5.
1996: Kevin J Leco; Dylan R Edwards; Gilbert A Schultz
Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus.
Molecular reproduction and development 1996;45(4):458-65.
1996: D S Inderdeo; Dylan R Edwards; V K M Han; Rama Khokha
Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.
Biology of reproduction 1996;55(3):498-508.
1996: Anna E Kossakowska; S A Huchcroft; Stefan J Urbanski; Dylan R Edwards
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans.
British journal of cancer 1996;73(11):1401-8.
1996: Dylan R Edwards; P P Beaudry; T D Laing; V Kowal; Kevin J Leco; P A Leco; Megan S Lim
The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20 Suppl 3():S9-15.
1996: Dylan R Edwards; Kevin J Leco; P P Beaudry; P W Atadja; Claude Veillette; Karl Riabowol
Differential effects of transforming growth factor-beta 1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts.
Experimental gerontology 1996;31(1-2):207-23.
1995: Warren B Nothnick; Dylan R Edwards; Kevin J Leco; Thomas E Curry
Expression and activity of ovarian tissue inhibitors of metalloproteinases during pseudopregnancy in the rat.
Biology of reproduction 1995;53(3):684-91.
1995: M B Harvey; Kevin J Leco; M Y Arcellana-Panlilio; X Zhang; Dylan R Edwards; Gilbert A Schultz
Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.
Development (Cambridge, England) 1995;121(4):1005-14.
1995: M B Harvey; Kevin J Leco; M Y Arcellana-Panlilio; X Zhang; Dylan R Edwards; Gilbert A Schultz
Roles of growth factors during peri-implantation development.
Human reproduction (Oxford, England) 1995;10(3):712-8.
1994: Kevin J Leco; Rama Khokha; N Pavloff; S P Hawkes; Dylan R Edwards
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
The Journal of biological chemistry 1994;269(12):9352-60.
1993: Stefan J Urbanski; Dylan R Edwards; N Hershfield; S A Huchcroft; E Shaffer; L Sutherland; Anna E Kossakowska
Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1993;2(2):81-9.
1993: Anna E Kossakowska; Stefan J Urbanski; A Watson; L J Hayden; Dylan R Edwards
Patterns of expression of metalloproteinases and their inhibitors in human malignant lymphomas.
Oncology research 1993;5(1):19-28.
1992: Stefan J Urbanski; Dylan R Edwards; A Maitland; Kevin J Leco; A Watson; Anna E Kossakowska
Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas.
British journal of cancer 1992;66(6):1188-94.
1992: Dylan R Edwards; H Rocheleau; R R Sharma; A J Wills; A Cowie; John A Hassell; J K Heath
Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.
Biochimica et biophysica acta 1992;1171(1):41-55.
1992: Kevin J Leco; L J Hayden; R R Sharma; H Rocheleau; A H Greenberg; Dylan R Edwards
Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts.
Gene 1992;117(2):209-17.
1992: Dylan R Edwards; L C Mahadevan
Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.
The EMBO journal 1992;11(7):2415-24.
1992: Dylan R Edwards; J K Heath; Brigid L M Hogan; S Nomura; A J Wills
Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization.
Matrix (Stuttgart, Germany). Supplement 1992;1():286-93.
1992: Anna E Kossakowska; Stefan J Urbanski; S A Huchcroft; Dylan R Edwards
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Oncology research 1992;4(6):233-40.
1991: Anna E Kossakowska; Stefan J Urbanski; Dylan R Edwards
Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas.
Blood 1991;77(11):2475-81.
1991: J S Mann; Mark S Kindy; Dylan R Edwards; Thomas E Curry
Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries.
Endocrinology 1991;128(4):1825-32.
1991: D T Denhardt; Dylan R Edwards; M Mcleod; G Norton; C L Parfett; M Zimmer
Spontaneous immortalization of mouse embryo cells: strain differences and changes in gene expression with particular reference to retroviral gag-pol genes.
Experimental cell research 1991;192(1):128-36.
1990: X J Guo; Ann F Chambers; C L Parfett; P Waterhouse; L C Murphy; R E Reid; A M Craig; Dylan R Edwards; D T Denhardt
Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(7):333-8.
1989: C L Parfett; R Hofbauer; Katrina Brudzynski; Dylan R Edwards; D T Denhardt
Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs.
Gene 1989;82(2):291-303.
1989: S Nomura; Brigid L M Hogan; A J Wills; J K Heath; Dylan R Edwards
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.
Development (Cambridge, England) 1989;105(3):575-83.
1989: S Nomura; A J Wills; Dylan R Edwards; J K Heath; Brigid L M Hogan
Expression of genes for non-collagenous proteins during embryonic bone formation.
Connective tissue research 1989;21(1-4):31-5; discussion 36-9.
1988: A M Chan; H W King; E A Deakin; P R Tempest; J Hilkens; V Kroezen; Dylan R Edwards; A J Wills; P Brookes; Colin S Cooper
Characterization of the mouse met proto-oncogene.
Oncogene 1988;2(6):593-9.
1988: S Nomura; A J Wills; Dylan R Edwards; J K Heath; Brigid L M Hogan
Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization.
The Journal of cell biology 1988;106(2):441-50.
1986: D T Denhardt; Dylan R Edwards; C L Parfett
Gene expression during the mammalian cell cycle.
Biochimica et biophysica acta 1986;865(2):83-125.