Dylan Edwards

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Chemicals & Drugs

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Harvey Amanda J; Pennington Caroline J; Porter Sarah; Burmi Rajpal S; Edwards Dylan R; Court William; Eccles Suzanne A; Crompton Mark R
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.
Frutkin Andrew D; Otsuka Goro; Stempien-Otero April; Sesti Casilde; Du Liang; Jaffe Mia; Dichek Helén L; Pennington Caroline J; Edwards Dylan R; Nieves-Cintrón Madeline; Minter Daniel; Preusch Michael; Hu Jie Hong; Marie Julien C; Dichek David A
TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.
Maretzky Thorsten; Le Gall Sylvain M; Worpenberg-Pietruk Susanne; Eder Jörg; Overall Christopher M; Huang Xin-Yun; Poghosyan Zaruhi; Edwards Dylan R; Blobel Carl P
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.

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All Publications

2009: Harvey Amanda J; Pennington Caroline J; Porter Sarah; Burmi Rajpal S; Edwards Dylan R; Court William; Eccles Suzanne A; Crompton Mark R
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.
The American journal of pathology 2009;175(3):1226-34.
2009: Frutkin Andrew D; Otsuka Goro; Stempien-Otero April; Sesti Casilde; Du Liang; Jaffe Mia; Dichek Helén L; Pennington Caroline J; Edwards Dylan R; Nieves-Cintrón Madeline; Minter Daniel; Preusch Michael; Hu Jie Hong; Marie Julien C; Dichek David A
TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1251-7.
2009: Maretzky Thorsten; Le Gall Sylvain M; Worpenberg-Pietruk Susanne; Eder Jörg; Overall Christopher M; Huang Xin-Yun; Poghosyan Zaruhi; Edwards Dylan R; Blobel Carl P
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.
Cancer research 2009;69(11):4573-6.
2009: Boutet Philippe; Agüera-González Sonia; Atkinson Susan; Pennington Caroline J; Edwards Dylan R; Murphy Gillian; Reyburn Hugh T; Valés-Gómez Mar
Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):49-53.
2009: Hancox Rachael A; Allen Michael D; Holliday Deborah L; Edwards Dylan R; Pennington Caroline J; Guttery David S; Shaw Jacqueline A; Walker Rosemary A; Pringle J Howard; Jones J Louise
Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms.
Breast cancer research : BCR 2009;11(2):R24.
2008: Stewart Grant D; Gray Kelly; Pennington Caroline J; Edwards Dylan R; Riddick Antony C P; Ross James A; Habib Fouad K
Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score.
Oncology reports 2008;20(6):1561-7.
2008: Edwards Dylan R; Handsley Madeleine M; Pennington Caroline J
The ADAM metalloproteinases.
Molecular aspects of medicine 2008;29(5):258-89.
2008: Stewart G D; Skipworth R J E; Pennington C J; Lowrie A G; Deans D A C; Edwards D R; Habib F K; Riddick A C P; Fearon K C H; Ross J A
Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines.
British journal of cancer 2008;99(1):126-32.
2008: Gutiérrez-Fernández Ana; Fueyo Antonio; Folgueras Alicia R; Garabaya Cecilia; Pennington Caroline J; Pilgrim Simon; Edwards Dylan R; Holliday Deborah L; Jones J Louise; Span Paul N; Sweep Fred C G J; Puente Xose S; López-Otín Carlos
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Cancer research 2008;68(8):2755-63.
2008: Folgueras Alicia R; Fueyo Antonio; García-Suárez Olivia; Cox Jennifer; Astudillo Aurora; Tortorella Paolo; Campestre Cristina; Gutiérrez-Fernández Ana; Fanjul-Fernández Miriam; Pennington Caroline J; Edwards Dylan R; Overall Christopher M; López-Otín Carlos
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
The Journal of biological chemistry 2008;283(14):9465-74.
2008: Gerg Michael; Kopitz Charlotte; Schaten Susanne; Tschukes Alexander; Kahlert Christoph; Stangl Manfred; von Weyhern Claus W Hann; Brücher Björn L D M; Edwards Dylan R; Brand Karsten; Krüger Achim
Distinct functionality of tumor cell-derived gelatinases during formation of liver metastases.
Molecular cancer research : MCR 2008;6(3):341-51.
2008: Zhong Julia L; Poghosyan Zaruhi; Pennington Caroline J; Scott Xanthe; Handsley Madeleine M; Warn Alba; Gavrilovic Jelena; Honert Katja; Krüger Achim; Span Paul N; Sweep Fred C G J; Edwards Dylan R
Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.
Molecular cancer research : MCR 2008;6(3):383-94.
2008: Shukla Chitranjan J; Pennington Caroline J; Riddick Antony C P; Sethia Krishna K; Ball Richard Y; Edwards Dylan R W
Laser-capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour-stroma interactions.
BJU international 2008;101(6):765-74.
2008: Sampieri Clara L; Nuttall Robert K; Young David A; Goldspink Deborah; Clark Ian M; Edwards Dylan R
Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(2):128-38.
2008: Nielsen Boye S; Egeblad Mikala; Rank Fritz; Askautrud Hanne A; Pennington Caroline J; Pedersen Tanja X; Christensen Ib J; Edwards Dylan R; Werb Zena; Lund Leif R
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
PloS one 2008;3(8):e2959.
2008: Clark Ian M; Swingler Tracey E; Sampieri Clara L; Edwards Dylan R
The regulation of matrix metalloproteinases and their inhibitors.
The international journal of biochemistry & cell biology 2008;40(6-7):1362-78.
2007: Kopitz Charlotte; Gerg Michael; Bandapalli Obul Reddy; Ister Dilek; Pennington Caroline J; Hauser Stephanie; Flechsig Christin; Krell Hans-Willi; Antolovic Dalibor; Brew Keith; Nagase Hideaki; Stangl Manfred; von Weyhern Claus W Hann; Brücher Björn L D M; Brand Karsten; Coussens Lisa M; Edwards Dylan R; Krüger Achim
Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.
Cancer research 2007;67(18):8615-23.
2007: Hodgkinson Lisa M; Duncan George; Wang Lixin; Pennington Caroline J; Edwards Dylan R; Wormstone I Michael
MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells.
Investigative ophthalmology & visual science 2007;48(9):4192-9.
2007: Rooprai Harcharan K; Kyriazis Ioannis; Nuttall Robert K; Edwards Dylan R; Zicha Daniel; Aubyn Deborah; Davies Derek; Gullan Richard; Pilkington Geoffrey J
Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro.
International journal of oncology 2007;30(5):1263-71.
2007: Nuttall Robert K; Silva Claudia; Hader Walter; Bar-Or Amit; Patel Kamala D; Edwards Dylan R; Yong V Wee
Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia.
Glia 2007;55(5):516-26.
2007: Harris James E; Nuttall Robert K; Elkington Paul T; Green Justin A; Horncastle Donna E; Graeber Manuel B; Edwards Dylan R; Friedland Jon S
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):1199-207.
2006: Sarkar Susobhan; Nuttall Robert K; Liu Shuhong; Edwards Dylan R; Yong V Wee
Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.
Cancer research 2006;66(24):11771-80.
2006: Pitchers M; Stokes A; Lonsdale R; Premachandra D J; Edwards D R
Research tissue banking in otolaryngology: organization, methods and uses, with reference to practical, ethical and legal issues.
The Journal of laryngology and otology 2006;120(6):433-8.
2006: García-Alvarez Jorge; Ramirez Remedios; Checa Marco; Nuttall Robert K; Sampieri Clara L; Edwards Dylan R; Selman Moisés; Pardo Annie
Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.
Experimental lung research 2006;32(5):201-14.
2006: Chabottaux Vincent; Sounni Nor Eddine; Pennington Caroline J; English William R; van den Brûle Frédéric; Blacher Silvia; Gilles Christine; Munaut Carine; Maquoi Erik; Lopez-Otin Carlos; Murphy Gillian; Edwards Dylan R; Foidart Jean-Michel; Noël Agnès
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Cancer research 2006;66(10):5165-72.
2006: García-Alvarez Jorge; Ramirez Remedios; Sampieri Clara L; Nuttall Robert K; Edwards Dylan R; Selman Moises; Pardo Annie
Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2006;23(1):13-21.
2006: Jones Gavin C; Corps Anthony N; Pennington Caroline J; Clark Ian M; Edwards Dylan R; Bradley Michelle M; Hazleman Brian L; Riley Graham P
Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.
Arthritis and rheumatism 2006;54(3):832-42.
2006: Porter Sarah; Span Paul N; Sweep Fred C G J; Tjan-Heijnen Vivianne C G; Pennington Caroline J; Pedersen Tanja X; Johnsen Morten; Lund Leif R; Rømer John; Edwards Dylan R
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
International journal of cancer. Journal international du cancer 2006;118(5):1241-7.
2005: Elkington Paul T G; Nuttall Robert K; Boyle Joseph J; O'Kane Cecilia M; Horncastle Donna E; Edwards Dylan R; Friedland Jon S
Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.
American journal of respiratory and critical care medicine 2005;172(12):1596-604.
2005: Weaver Andrew; Goncalves da Silva Angelika; Nuttall Robert K; Edwards Dylan R; Shapiro Steven D; Rivest Serge; Yong V Wee
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1668-70.
2005: Kassiri Zamaneh; Oudit Gavin Y; Sanchez Otto; Dawood Fayez; Mohammed Fazilat F; Nuttall Robert K; Edwards Dylan R; Liu Peter P; Backx Peter H; Khokha Rama
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Circulation research 2005;97(4):380-90.
2005: Singh Robert J R; Mason Justin C; Lidington Elaine A; Edwards Dylan R; Nuttall Robert K; Khokha Rama; Knauper Vera; Murphy Gillian; Gavrilovic Jelena
Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Cardiovascular research 2005;67(1):39-49.
2005: Pedersen Tanja Xenia; Pennington Caroline J; Almholt Kasper; Christensen Ib Jarle; Nielsen Boye Schnack; Edwards Dylan R; Rømer John; Danø Keld; Johnsen Morten
Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.
Carcinogenesis 2005;26(7):1233-40.
2005: Handsley Madeleine M; Edwards Dylan R
Metalloproteinases and their inhibitors in tumor angiogenesis.
International journal of cancer. Journal international du cancer 2005;115(6):849-60.
2005: Riddick A C P; Shukla C J; Pennington C J; Bass R; Nuttall R K; Hogan A; Sethia K K; Ellis V; Collins A T; Maitland N J; Ball R Y; Edwards D R
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.
British journal of cancer 2005;92(12):2171-80.
2005: Young David A; Billingham Olivia; Sampieri Clara L; Edwards Dylan R; Clark Ian M
Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression.
The FEBS journal 2005;272(8):1912-26.
2005: Mohammed Fazilat F; Pennington Caroline J; Kassiri Zamaneh; Rubin Jeffrey S; Soloway Paul D; Ruther Ulrich; Edwards Dylan R; Khokha Rama
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(4):857-67.
2005: Denton Christopher P; Lindahl Gisela E; Khan Korsa; Shiwen Xu; Ong Voon H; Gaspar Nicholas J; Lazaridis Konstantinos; Edwards Dylan R; Leask Andrew; Eastwood Mark; Leoni Patricia; Renzoni Elisabetta A; Bou Gharios George; Abraham David J; Black Carol M
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
The Journal of biological chemistry 2005;280(16):16053-65.
2005: Porter Sarah; Clark Ian M; Kevorkian Lara; Edwards Dylan R
The ADAMTS metalloproteinases.
The Biochemical journal 2005;386(Pt 1):15-27.
2005: Young David A; Lakey Rachel L; Pennington Caroline J; Jones Debra; Kevorkian Lara; Edwards Dylan R; Cawston Timothy E; Clark Ian M
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Arthritis research & therapy 2005;7(3):R503-12.
2004: Toft-Hansen Henrik; Nuttall Robert K; Edwards Dylan R; Owens Trevor
Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5209-18.
2004: Young David A; Gavrilov Svetlana; Pennington Caroline J; Nuttall Robert K; Edwards Dylan R; Kitsis Richard N; Clark Ian M
Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes.
Biochemical and biophysical research communications 2004;322(3):759-65.
2004: Edwards Dylan R
TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges.
The Journal of pathology 2004;202(4):391-4.
2004: Porter Sarah; Scott Stuart D; Sassoon Elaine M; Williams Mark R; Jones J Louise; Girling Anne C; Ball Richard Y; Edwards Dylan R
Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2429-40.
2004: Nuttall Robert K; Sampieri Clara L; Pennington Caroline J; Gill Sean E; Schultz Gilbert A; Edwards Dylan R
Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.
FEBS letters 2004;563(1-3):129-34.
2004: Kevorkian Lara; Young David A; Darrah Clare; Donell Simon T; Shepstone Lee; Porter Sarah; Brockbank Sarah M V; Edwards Dylan R; Parker Andrew E; Clark Ian M
Expression profiling of metalloproteinases and their inhibitors in cartilage.
Arthritis and rheumatism 2004;50(1):131-41.
2003: Worley Joanna R; Baugh Mark D; Hughes David A; Edwards Dylan R; Hogan Aileen; Sampson Mike J; Gavrilovic Jelena
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
The Journal of biological chemistry 2003;278(51):51340-6.
2003: Moorehead Roger A; Hojilla Carlo V; De Belle Ian; Wood Geoffrey A; Fata Jimmie E; Adamson Eileen D; Watson Katrina L M; Edwards Dylan R; Khokha Rama
Insulin-like growth factor-II regulates PTEN expression in the mammary gland.
The Journal of biological chemistry 2003;278(50):50422-7.
2003: Bar-Or Amit; Nuttall Robert K; Duddy Martin; Alter Andrea; Kim Ho Jin; Ifergan Igal; Pennington Caroline J; Bourgoin Pierre; Edwards Dylan R; Yong V Wee
Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.
Brain : a journal of neurology 2003;126(Pt 12):2738-49.
2003: Wells Jennifer E A; Rice Tiffany K; Nuttall Robert K; Edwards Dylan R; Zekki Hakima; Rivest Serge; Yong V Wee
An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(31):10107-15.
2003: Platt C I; Krekoski C A; Ward R V; Edwards D R; Gavrilovic J
Extracellular matrix and matrix metalloproteinases in sciatic nerve.
Journal of neuroscience research 2003;74(3):417-29.
2003: Banke Ingo J; Arlt Matthias J E; Pennington Caroline; Kopitz Charlotte; Steinmetzer Torsten; Schweinitz Andrea; Gansbacher Bernd; Quigley James P; Edwards Dylan R; Stürzebecher Jörg; Krüger Achim
Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.
Biological chemistry 2003;384(10-11):1515-25.
2003: Lafleur Marc A; Handsley Madeleine M; Edwards Dylan R
Metalloproteinases and their inhibitors in angiogenesis.
Expert reviews in molecular medicine 2003;5(23):1-39.
2003: Worley Joanna R; Thompkins Philip B; Lee Meng H; Hutton Mike; Soloway Paul; Edwards Dylan R; Murphy Gillian; Knäuper Vera
Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).
The Biochemical journal 2003;372(Pt 3):799-809.
2003: Alter Andrea; Duddy Martin; Hebert Sherry; Biernacki Katarzyna; Prat Alexandre; Antel Jack P; Yong Voon Wee; Nuttall Robert K; Pennington Caroline J; Edwards Dylan R; Bar-Or Amit
Determinants of human B cell migration across brain endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4497-505.
2003: Palosaari Heidi; Pennington Caroline J; Larmas Markku; Edwards Dylan R; Tjäderhane Leo; Salo Tuula
Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue.
European journal of oral sciences 2003;111(2):117-27.
2003: Nuttall Robert K; Pennington Caroline J; Taplin Jennifer; Wheal Alison; Yong Voon Wee; Forsyth Peter A; Edwards Dylan R
Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells.
Molecular cancer research : MCR 2003;1(5):333-45.
2003: Riddick A C P; Barker C; Sheriffs I; Bass R; Ellis V; Sethia K K; Edwards D R; Ball R Y
Banking of fresh-frozen prostate tissue: methods, validation and use.
BJU international 2003;91(4):315-23; discussion 323-4.
2003: Hall Marie-Claire; Young David A; Waters Jasmine G; Rowan Andrew D; Chantry Andrew; Edwards Dylan R; Clark Ian M
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.
The Journal of biological chemistry 2003;278(12):10304-13.
2002: van Kempen Léon C L; Rhee Jin-Sae; Dehne Kerstin; Lee Jake; Edwards Dylan R; Coussens Lisa M
Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment.
Differentiation; research in biological diversity 2002;70(9-10):610-23.
2002: Radomski Anna; Jurasz Paul; Sanders Esmond J; Overall Christopher M; Bigg Heather F; Edwards Dylan R; Radomski Marek W
Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets.
British journal of pharmacology 2002;137(8):1330-8.
2002: Hall M-C; Young D A; Rowan A D; Edwards D R; Clark I M
Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors.
BioTechniques 2002;33(5):1004, 1006, 1008.
2002: Price Jo S; Waters Jasmine G; Darrah Clare; Pennington Caroline; Edwards Dylan R; Donell Simon T; Clark Ian M
The role of chondrocyte senescence in osteoarthritis.
Aging cell 2002;1(1):57-65.
2002: Arlt Matthias; Kopitz Charlotte; Pennington Caroline; Watson Katrina L M; Krell Hans-Willi; Bode Wolfram; Gansbacher Bernd; Khokha Rama; Edwards Dylan R; Krüger Achim
Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.
Cancer research 2002;62(19):5543-50.
2002: Baker Andrew H; Edwards Dylan R; Murphy Gillian
Metalloproteinase inhibitors: biological actions and therapeutic opportunities.
Journal of cell science 2002;115(Pt 19):3719-27.
2002: Lafleur Marc A; Handsley Madeleine M; Knäuper Vera; Murphy Gillian; Edwards Dylan R
Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).
Journal of cell science 2002;115(Pt 17):3427-38.
2002: Wall Steven J; Bevan Damon; Thomas David W; Harding Keith G; Edwards Dylan R; Murphy Gillian
Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse.
The Journal of investigative dermatology 2002;119(1):91-8.
2002: Young David A; Phillips Blaine W; Lundy Caroline; Nuttall Robert K; Hogan Aileen; Schultz Gilbert A; Leco Kevin J; Clark Ian M; Edwards Dylan R
Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.
The Biochemical journal 2002;364(Pt 1):89-99.
2002: Koshy P J T; Lundy C J; Rowan A D; Porter S; Edwards D R; Hogan A; Clark I M; Cawston T E
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
Arthritis and rheumatism 2002;46(4):961-7.
2002: Qi Jian Hua; Ebrahem Quteba; Yeow Karen; Edwards Dylan R; Fox Paul L; Anand-Apte Bela
Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis.
The Journal of biological chemistry 2002;277(16):13394-400.
2002: Jung Jae-Chang; Leco Kevin J; Edwards Dylan R; Fini M Elizabeth
Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption.
Developmental dynamics : an official publication of the American Association of Anatomists 2002;223(3):402-13.
2002: Poghosyan Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The Journal of biological chemistry 2002;277(7):4999-5007.
2002: Yeow Karen M; Kishnani Narendra S; Hutton Mike; Hawkes Susan P; Murphy Gillian; Edwards Dylan R
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(1):75-88.
2002: Wall Steven J; Edwards Dylan R
Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs.
Analytical biochemistry 2002;300(2):269-73.
2001: Maillard M; Cadot B; Ball R Y; Sethia K; Edwards D R; Perbal B; Tatoud R
Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.
Molecular pathology : MP 2001;54(4):275-80.
2001: Groft L L; Muzik H; Rewcastle N B; Johnston R N; Knäuper V; Lafleur M A; Forsyth P A; Edwards D R
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas.
British journal of cancer 2001;85(1):55-63.
2001: Yong V W; Power C; Forsyth P; Edwards D R
Metalloproteinases in biology and pathology of the nervous system.
Nature reviews. Neuroscience 2001;2(7):502-11.
2001: Lafleur M A; Hollenberg M D; Atkinson S J; Knäuper V; Murphy G; Edwards D R
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.
The Biochemical journal 2001;357(Pt 1):107-15.
2001: Whiteside E J; Jackson M M; Herington A C; Edwards D R; Harvey M B
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos.
Biology of reproduction 2001;64(5):1331-7.
2001: Lafleur M A; Forsyth P A; Atkinson S J; Murphy G; Edwards D R
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity.
Biochemical and biophysical research communications 2001;282(2):463-73.
2001: Wong H; Muzik H; Groft L L; Lafleur M A; Matouk C; Forsyth P A; Schultz G A; Wall S J; Edwards D R
Monitoring MMP and TIMP mRNA expression by RT-PCR.
Methods in molecular biology (Clifton, N.J.) 2001;151():305-20.
2001: Yeow K M; Phillips B W; Beaudry P P; Leco K J; Murphy G; Edwards D R
Expression of MMPs and TIMPs in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2001;151():181-9.
2000: Harvey P; Clark I M; Jaurand M C; Warn R M; Edwards D R
Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases.
British journal of cancer 2000;83(9):1147-53.
2000: Dean G; Young D A; Edwards D R; Clark I M
The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1.
The Journal of biological chemistry 2000;275(42):32664-71.
2000: Raithatha S A; Muzik H; Muzik H; Rewcastle N B; Johnston R N; Edwards D R; Forsyth P A
Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas.
Neuro-oncology 2000;2(3):145-50.
1999: Oh L Y; Larsen P H; Krekoski C A; Edwards D R; Donovan F; Werb Z; Yong V W
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8464-75.
1999: Kossakowska A E; Edwards D R; Prusinkiewicz C; Zhang M C; Guo D; Urbanski S J; Grogan T; Marquez L A; Janowska-Wieczorek A
Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.
Blood 1999;94(6):2080-9.
1999: Phillips B W; Sharma R; Leco P A; Edwards D R
A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue inhibitor of metalloproteinases-1 (Timp-1) gene.
The Journal of biological chemistry 1999;274(32):22197-207.
1999: Kossakowska A E; Medlicott S A; Edwards D R; Guyn L; Stabbler A L; Sutherland L R; Urbanski S J
Elevated plasma gelatinase A (MMP-2) activity is associated with quiescent Crohn's Disease.
Annals of the New York Academy of Sciences 1999;878():578-80.
1999: Janowska-Wieczorek A; Marquez L A; Nabholtz J M; Cabuhat M L; Montaño J; Chang H; Rozmus J; Russell J A; Edwards D R; Turner A R
Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane.
Blood 1999;93(10):3379-90.
1999: Janowska-Wieczorek A; Marquez L A; Matsuzaki A; Hashmi H R; Larratt L M; Boshkov L M; Turner A R; Zhang M C; Edwards D R; Kossakowska A E
Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells.
British journal of haematology 1999;105(2):402-11.
1999: Forsyth P A; Wong H; Laing T D; Rewcastle N B; Morris D G; Muzik H; Leco K J; Johnston R N; Brasher P M; Sutherland G; Edwards D R
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.
British journal of cancer 1999;79(11-12):1828-35.
1999: Frölichsthal-Schoeller P; Vescovi A L; Krekoski C A; Murphy G; Edwards D R; Forsyth P
Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem cells.
Neuroreport 1999;10(2):345-51.
1998: Kossakowska A E; Edwards D R; Lee S S; Urbanski L S; Stabbler A L; Zhang C L; Phillips B W; Zhang Y; Urbanski S J
Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis.
The American journal of pathology 1998;153(6):1895-902.
1998: Yong V W; Krekoski C A; Forsyth P A; Bell R; Edwards D R
Matrix metalloproteinases and diseases of the CNS.
Trends in neurosciences 1998;21(2):75-80.
1998: Kossakowska A E; Hinek A; Edwards D R; Lim M S; Zhang C L; Breitman D R; Prusinkiewicz C; Stabbler A L; Urbanski L S; Urbanski S J
Proteolytic activity of human non-Hodgkin's lymphomas.
The American journal of pathology 1998;152(2):565-76.
1998: Forsyth P A; Laing T D; Gibson A W; Rewcastle N B; Brasher P; Sutherland G; Johnston R N; Edwards D R
High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma.
Journal of neuro-oncology 1998;36(1):21-9.
1997: Clark A W; Krekoski C A; Bou S S; Chapman K R; Edwards D R
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia.
Neuroscience letters 1997;238(1-2):53-6.
1997: Clark I M; Rowan A D; Edwards D R; Bech-Hansen T; Mann D A; Bahr M J; Cawston T E
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.
The Biochemical journal 1997;324 ( Pt 2)():611-7.
1997: Leco K J; Apte S S; Taniguchi G T; Hawkes S P; Khokha R; Schultz G A; Edwards D R
Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues.
FEBS letters 1997;401(2-3):213-7.
1997: Leco K J; Harvey M B; Hogan A; Copeland N G; Gilbert D J; Jenkins N A; Edwards D R; Schultz G A
Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse.
Developmental genetics 1997;21(1):55-60.
1997: Schultz G A; Edwards D R
Biology and genetics of implantation.
Developmental genetics 1997;21(1):1-5.
1996: Leco K J; Edwards D R; Schultz G A
Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus.
Molecular reproduction and development 1996;45(4):458-65.
1996: Inderdeo D S; Edwards D R; Han V K; Khokha R
Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.
Biology of reproduction 1996;55(3):498-508.
1996: Kossakowska A E; Huchcroft S A; Urbanski S J; Edwards D R
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans.
British journal of cancer 1996;73(11):1401-8.
1996: Edwards D R; Beaudry P P; Laing T D; Kowal V; Leco K J; Leco P A; Lim M S
The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20 Suppl 3():S9-15.
1996: Edwards D R; Leco K J; Beaudry P P; Atadja P W; Veillette C; Riabowol K T
Differential effects of transforming growth factor-beta 1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts.
Experimental gerontology 1996;31(1-2):207-23.
1995: Nothnick W B; Edwards D R; Leco K J; Curry T E
Expression and activity of ovarian tissue inhibitors of metalloproteinases during pseudopregnancy in the rat.
Biology of reproduction 1995;53(3):684-91.
1995: Harvey M B; Leco K J; Arcellana-Panlilio M Y; Zhang X; Edwards D R; Schultz G A
Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.
Development (Cambridge, England) 1995;121(4):1005-14.
1995: Harvey M B; Leco K J; Arcellana-Panlilio M Y; Zhang X; Edwards D R; Schultz G A
Roles of growth factors during peri-implantation development.
Human reproduction (Oxford, England) 1995;10(3):712-8.
1994: Leco K J; Khokha R; Pavloff N; Hawkes S P; Edwards D R
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
The Journal of biological chemistry 1994;269(12):9352-60.
1993: Urbanski S J; Edwards D R; Hershfield N; Huchcroft S A; Shaffer E; Sutherland L; Kossakowska A E
Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1993;2(2):81-9.
1993: Kossakowska A E; Urbanski S J; Watson A; Hayden L J; Edwards D R
Patterns of expression of metalloproteinases and their inhibitors in human malignant lymphomas.
Oncology research 1993;5(1):19-28.
1992: Urbanski S J; Edwards D R; Maitland A; Leco K J; Watson A; Kossakowska A E
Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas.
British journal of cancer 1992;66(6):1188-94.
1992: Edwards D R; Rocheleau H; Sharma R R; Wills A J; Cowie A; Hassell J A; Heath J K
Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.
Biochimica et biophysica acta 1992;1171(1):41-55.
1992: Leco K J; Hayden L J; Sharma R R; Rocheleau H; Greenberg A H; Edwards D R
Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts.
Gene 1992;117(2):209-17.
1992: Edwards D R; Mahadevan L C
Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.
The EMBO journal 1992;11(7):2415-24.
1992: Edwards D R; Heath J K; Hogan B L; Nomura S; Wills A J
Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization.
Matrix (Stuttgart, Germany). Supplement 1992;1():286-93.
1992: Kossakowska A E; Urbanski S J; Huchcroft S A; Edwards D R
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Oncology research 1992;4(6):233-40.
1991: Kossakowska A E; Urbanski S J; Edwards D R
Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas.
Blood 1991;77(11):2475-81.
1991: Mann J S; Kindy M S; Edwards D R; Curry T E
Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries.
Endocrinology 1991;128(4):1825-32.
1991: Denhardt D T; Edwards D R; Mcleod M; Norton G; Parfett C L; Zimmer M
Spontaneous immortalization of mouse embryo cells: strain differences and changes in gene expression with particular reference to retroviral gag-pol genes.
Experimental cell research 1991;192(1):128-36.
1990: Guo X J; Chambers A F; Parfett C L; Waterhouse P; Murphy L C; Reid R E; Craig A M; Edwards D R; Denhardt D T
Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(7):333-8.
1989: Parfett C L; Hofbauer R; Brudzynski K; Edwards D R; Denhardt D T
Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs.
Gene 1989;82(2):291-303.
1989: Nomura S; Hogan B L; Wills A J; Heath J K; Edwards D R
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.
Development (Cambridge, England) 1989;105(3):575-83.
1989: Nomura S; Wills A J; Edwards D R; Heath J K; Hogan B L
Expression of genes for non-collagenous proteins during embryonic bone formation.
Connective tissue research 1989;21(1-4):31-5; discussion 36-9.
1988: Chan A M; King H W; Deakin E A; Tempest P R; Hilkens J; Kroezen V; Edwards D R; Wills A J; Brookes P; Cooper C S
Characterization of the mouse met proto-oncogene.
Oncogene 1988;2(6):593-9.
1988: Nomura S; Wills A J; Edwards D R; Heath J K; Hogan B L
Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization.
The Journal of cell biology 1988;106(2):441-50.
1986: Denhardt D T; Edwards D R; Parfett C L
Gene expression during the mammalian cell cycle.
Biochimica et biophysica acta 1986;865(2):83-125.

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