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Geoffrey Edwards

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Andrew V Stachulski; Eleanor Row; J Edward Semple; Raman Sharma; Sarah A Allman; Joanne Bentley; Neil G Berry; Geoffrey Edwards; Jennifer Hellier; Alison Helm; Mazhar Iqbal; Brent E Korba; Chandrakala Pidathala; Jean-François Rossignol
Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.
Geoffrey Edwards; Giancarlo A Biagini
Resisting resistance: dealing with the irrepressible problem of malaria.
James L Maggs; Laurence P D Bishop; Kevin Batty; Charlotte C Dodd; Kenneth F Ilett; Paul M O'Neill; Geoffrey Edwards; B Kevin Park
Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.

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2011: Andrew V Stachulski; Eleanor Row; J Edward Semple; Raman Sharma; Sarah A Allman; Joanne Bentley; Neil G Berry; Geoffrey Edwards; Jennifer Hellier; Alison Helm; Mazhar Iqbal; Brent E Korba; Chandrakala Pidathala; Jean-François Rossignol
Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.
Journal of medicinal chemistry 2011;54(12):4119-32.
2006: Geoffrey Edwards; Giancarlo A Biagini
Resisting resistance: dealing with the irrepressible problem of malaria.
British journal of clinical pharmacology 2006;61(6):690-3.
2004: James L Maggs; Laurence P D Bishop; Kevin Batty; Charlotte C Dodd; Kenneth F Ilett; Paul M O'Neill; Geoffrey Edwards; B Kevin Park
Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.
Chemico-biological interactions 2004;147(2):173-84.
2002: Kenneth F Ilett; Brian T Ethell; James L Maggs; Timothy Davis; Kevin Batty; Brian Burchell; Tran Quang Binh; Le Thi Anh Thu; Nguyen Canh Hung; Munir Pirmohamed; B Kevin Park; Geoffrey Edwards
Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):1005-12.
2001: S L Smith; C J Sadler; Charlotte C Dodd; Geoffrey Edwards; Stephen A Ward; B Kevin Park; W Graham McLean
The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.
Biochemical pharmacology 2001;61(4):409-16.
2001: ID Lightbown; J P Lambert; Geoffrey Edwards; Susan J Coker
Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine.
British journal of pharmacology 2001;132(1):197-204.
2000: H C Rawden; G O Kokwaro; S A Ward; Geoffrey Edwards
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
British journal of clinical pharmacology 2000;49(4):313-22.
2000: James L Maggs; Laurence P D Bishop; Geoffrey Edwards; Paul M O'Neill; Stephen A Ward; Peter A Winstanley; B Kevin Park
Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):209-17.
1998: Kevin Batty; Kenneth F Ilett; Geoffrey Edwards; Shane M Powell; James L Maggs; B Kevin Park; Timothy Davis
Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes.
British journal of pharmacology 1998;125(1):159-67.
1998: J Fishwick; Geoffrey Edwards; Stephen A Ward; W Graham McLean
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate.
Neurotoxicology 1998;19(3):405-12.
1998: J Fishwick; Geoffrey Edwards; Stephen A Ward; W Graham McLean
Morphological and immunocytochemical effects of dihydroartemisinin on differentiating NB2a neuroblastoma cells.
Neurotoxicology 1998;19(3):393-403.
1997: Andrew J Batey; ID Lightbown; J P Lambert; Geoffrey Edwards; Susan J Coker
Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs.
British journal of pharmacology 1997;122(3):563-9.
1997: S L Smith; J Fishwick; W Graham McLean; Geoffrey Edwards; Stephen A Ward
Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin.
Biochemical pharmacology 1997;53(1):5-10.
1995: Peter A Winstanley; S Khoo; S Szwandt; Geoffrey Edwards; E Wilkins; J Tija; R Coker; W McKane; N Beeching; S Watkin
Marked variation in pyrimethamine disposition in AIDS patients treated for cerebral toxoplasmosis.
The Journal of antimicrobial chemotherapy 1995;36(2):435-9.
1995: J Fishwick; W Graham McLean; Geoffrey Edwards; Stephen A Ward
The toxicity of artemisinin and related compounds on neuronal and glial cells in culture.
Chemico-biological interactions 1995;96(3):263-71.
1995: S Ismail; K Na Bangchang; J Karbwang; David J Back; Geoffrey Edwards
Paracetamol disposition in Thai patients during and after treatment of falciparum malaria.
European journal of clinical pharmacology 1995;48(1):65-9.
1994: Geoffrey Edwards; Peter A Winstanley; Stephen A Ward
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Clinical pharmacokinetics 1994;27(2):150-65.
1994: A P Glazier; G O Kokwaro; S Ismail; Geoffrey Edwards
Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(8):785-93.
1994: Geoffrey Edwards
Measurement of artemisinin and its derivatives in biological fluids.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88 Suppl 1():S37-9.
1994: S Ismail; G O Kokwaro; David J Back; Geoffrey Edwards
Effect of malaria infection on the pharmacokinetics of paracetamol in rat.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(6):527-33.
1994: A P Glazier; G O Kokwaro; Geoffrey Edwards
Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes.
The Journal of pharmacy and pharmacology 1994;46(5):352-5.
1993: G O Kokwaro; I S Szwandt; A P Glazier; Stephen A Ward; Geoffrey Edwards
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(12):1391-7.
1993: N A Helsby; Geoffrey Edwards; Alasdair M Breckenridge; Stephen A Ward
The multiple dose pharmacokinetics of proguanil.
British journal of clinical pharmacology 1993;35(6):653-6.
1993: G O Kokwaro; S Ismail; A P Glazier; Stephen A Ward; Geoffrey Edwards
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.
Biochemical pharmacology 1993;45(6):1243-9.
1993: G O Kokwaro; A P Glazier; Stephen A Ward; Alasdair M Breckenridge; Geoffrey Edwards
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Biochemical pharmacology 1993;45(6):1235-41.
1993: Geoffrey Edwards; C S McGrath; Stephen A Ward; Wichai Supanaranond; Sasithon Pukrittayakamee; Timothy Davis; N J White
Interactions among primaquine, malaria infection and other antimalarials in Thai subjects.
British journal of clinical pharmacology 1993;35(2):193-8.
1992: C G Thomas; Stephen A Ward; Geoffrey Edwards
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography 1992;583(1):131-6.
1992: S Ismail; David J Back; Geoffrey Edwards
The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes.
Biochemical pharmacology 1992;44(9):1879-82.
1992: S Wanwimolruk; Geoffrey Edwards; Stephen A Ward; Alasdair M Breckenridge
The binding of the antimalarial arteether to human plasma proteins in-vitro.
The Journal of pharmacy and pharmacology 1992;44(11):940-2.
1992: Geoffrey Edwards; Stephen A Ward
Methods in tropical pharmacology.
British journal of clinical pharmacology 1992;33(6):573-4.
1991: S M Mansor; Stephen A Ward; Geoffrey Edwards
The effect of fever on quinine and quinidine disposition in the rat.
The Journal of pharmacy and pharmacology 1991;43(10):705-8.
1991: S M Mansor; Malcolm E Molyneux; Terrie E Taylor; Stephen A Ward; J J Wirima; Geoffrey Edwards
Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1-acid glycoprotein and the binding of quinine in Malawian children.
British journal of clinical pharmacology 1991;32(3):317-21.
1991: S M Mansor; Stephen A Ward; Geoffrey Edwards; P E Hoaksey; Alasdair M Breckenridge
The influence of alpha 1-acid glycoprotein on quinine and quinidine disposition in the rat isolated perfused liver preparation.
The Journal of pharmacy and pharmacology 1991;43(9):650-4.
1991: S M Mansor; Geoffrey Edwards; P J Roberts; Stephen A Ward
The effect of malaria infection on paracetamol disposition in the rat.
Biochemical pharmacology 1991;41(11):1707-11.
1991: P E Hoaksey; Kwablah Awadzi; Stephen A Ward; P A Coventry; M L Orme; Geoffrey Edwards
Rapid and sensitive method for the determination of albendazole and albendazole sulphoxide in biological fluids.
Journal of chromatography 1991;566(1):244-9.
1990: S M Mansor; Terrie E Taylor; C S McGrath; Geoffrey Edwards; Stephen A Ward; J J Wirima; Malcolm E Molyneux
The safety and kinetics of intramuscular quinine in Malawian children with moderately severe falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(4):482-7.
1990: Peter A Winstanley; O Simooya; J M Kofi-Ekue; O Walker; Lateef A Salako; Geoffrey Edwards; M L Orme; Alasdair M Breckenridge
The disposition of amodiaquine in Zambians and Nigerians with malaria.
British journal of clinical pharmacology 1990;29(6):695-701.
1990: S M Mansor; Stephen A Ward; Geoffrey Edwards; P E Hoaksey; Alasdair M Breckenridge
The effect of malaria infection on the disposition of quinine and quinidine in the rat isolated perfused liver preparation.
The Journal of pharmacy and pharmacology 1990;42(6):428-32.
1990: K A Milton; P E Hoaksey; Stephen A Ward; Geoffrey Edwards
Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro.
Biochemical pharmacology 1990;39(10):1581-6.
1990: M Orme; Geoffrey Edwards; Kwablah Awadzi; A Breckenridge
Clinical pharmacokinetics of drugs against onchocerciasis.
Acta Leidensia 1990;59(1-2):329-42.
1989: O R Idowu; Stephen A Ward; Geoffrey Edwards
Determination of artelinic acid in blood plasma by high-performance liquid chromatography.
Journal of chromatography 1989;495():167-77.
1989: K A Milton; Geoffrey Edwards; Stephen A Ward; M L Orme; Alasdair M Breckenridge
Pharmacokinetics of halofantrine in man: effects of food and dose size.
British journal of clinical pharmacology 1989;28(1):71-7.
1988: K A Milton; Stephen A Ward; Geoffrey Edwards
Determination of halofantrine and its principal metabolite desbutylhalofantrine in biological fluids by reversed-phase high-performance liquid chromatography.
Journal of chromatography 1988;433():339-44.
1988: Geoffrey Edwards; A M Breckenridge
Clinical pharmacokinetics of anthelmintic drugs.
Clinical pharmacokinetics 1988;15(2):67-93.
1988: Peter A Winstanley; Geoffrey Edwards; C G Curtis; M L Orme; G M Powell; Alasdair M Breckenridge
Tissue distribution and excretion of amodiaquine in the rat.
The Journal of pharmacy and pharmacology 1988;40(5):343-9.
1988: Geoffrey Edwards; S Looareesuwan; A J Davies; Y Wattanagoon; R E Phillips; D A Warrell
Pharmacokinetics of chloroquine in Thais: plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria.
British journal of clinical pharmacology 1988;25(4):477-85.
1988: Geoffrey Edwards; A Dingsdale; N Helsby; M L Orme; Alasdair M Breckenridge
The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution.
European journal of clinical pharmacology 1988;35(6):681-4.
1987: Geoffrey Edwards; A J Davies; R E Phillips; S Looareesuwan; J Karbwang; N J White; D A Warrell
Plasma concentrations and toxicity of chloroquine after slow intravenous infusion in patients with falciparum malaria.
Annals of tropical medicine and parasitology 1987;81(2):79-84.