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James Edwards

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John J M Wiener; James P Edwards; Lars Karlsson; Steven Nguyen; Michele Rizzolio; Raymond Rynberg; Siquan Sun; Alvah Tyson Wickboldt; Cheryl A Grice
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.
Brad M Savall; Robin Thurmond; Frank Chavez; Jeffery Cowden; Michael Curtis; Paul J Dunford; Laurent Gomez; Cheryl Grice; Aaron Kearney; Steven P Meduna; James P Edwards
Tricyclic aminopyrimidine histamine H4 receptor antagonists.
Steven P Meduna; Brad M Savall; Hui Cai; James P Edwards; Robin Thurmond; Patricia M McGovern
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

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2013: John J M Wiener; James P Edwards; Lars Karlsson; Steven Nguyen; Michele Rizzolio; Raymond Rynberg; Siquan Sun; Alvah Tyson Wickboldt; Cheryl A Grice
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.
Bioorganic & medicinal chemistry letters 2013;23(4):1070-4.
2011: Brad M Savall; Robin Thurmond; Frank Chavez; Jeffery Cowden; Michael Curtis; Paul J Dunford; Laurent Gomez; Cheryl Grice; Aaron Kearney; Steven P Meduna; James P Edwards
Tricyclic aminopyrimidine histamine H4 receptor antagonists.
Bioorganic & medicinal chemistry letters 2011;21(21):6577-81.
2011: Steven P Meduna; Brad M Savall; Hui Cai; James P Edwards; Robin Thurmond; Patricia M McGovern
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
Bioorganic & medicinal chemistry letters 2011;21(10):3113-6.
2010: Michael K Ameriks; Scott D Bembenek; Matthew T Burdett; Ingrid C Choong; James P Edwards; Damara Gebauer; Yin Gu; Lars Karlsson; Hans E Purkey; Bart L Staker; Siquan Sun; Robin Thurmond; Jian Zhu
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(14):4060-4.
2010: Brad M Savall; James P Edwards; Jennifer D Venable; Daniel J Buzard; Robin Thurmond; Michael Hack; Patricia McGovern
Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
Bioorganic & medicinal chemistry letters 2010;20(11):3367-71.
2010: Danielle K Wiener; Alice Lee-Dutra; Scott Bembenek; Steven Nguyen; Robin Thurmond; Siquan Sun; Lars Karlsson; Cheryl A Grice; Todd K Jones; James P Edwards
Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(7):2379-82.
2010: John J M Wiener; Alvah T Wickboldt; Danielle K Wiener; Alice Lee-Dutra; James P Edwards; Lars Karlsson; Steven Nguyen; Siquan Sun; Todd K Jones; Cheryl A Grice
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.
Bioorganic & medicinal chemistry letters 2010;20(7):2375-8.
2010: Alice Lee-Dutra; Danielle K Wiener; Kristen L Arienti; Jing Liu; Neelakandha Mani; Michael K Ameriks; Frank U Axe; Damara Gebauer; Pragnya J Desai; Steven Nguyen; Mike Randal; Robin Thurmond; Siquan Sun; Lars Karlsson; James P Edwards; Todd K Jones; Cheryl A Grice
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.
Bioorganic & medicinal chemistry letters 2010;20(7):2370-4.
2009: Michael K Ameriks; Hui Cai; James P Edwards; Damara Gebauer; Elizabeth Gleason; Yin Gu; Lars Karlsson; Steven Nguyen; Siquan Sun; Robin Thurmond; Jian Zhu
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.
Bioorganic & medicinal chemistry letters 2009;19(21):6135-9.
2009: Michael K Ameriks; Frank U Axe; Scott D Bembenek; James P Edwards; Yin Gu; Lars Karlsson; Mike Randal; Siquan Sun; Robin Thurmond; Jian Zhu
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Bioorganic & medicinal chemistry letters 2009;19(21):6131-4.
2008: Ronald L Wolin; Scott D Bembenek; Jianmei Wei; Shelby Crawford; Katherine Lundeen; Anders Brunmark; Lars Karlsson; James P Edwards; Jon Blevitt
Dual binding site inhibitors of B-RAF kinase.
Bioorganic & medicinal chemistry letters 2008;18(9):2825-9.
2007: Jianmei Wei; Barbara Pio; Hui Cai; Steven P Meduna; Siquan Sun; Yin Gu; Wendy Jiang; Robin Thurmond; Lars Karlsson; James P Edwards
Pyrazole-based cathepsin S inhibitors with improved cellular potency.
Bioorganic & medicinal chemistry letters 2007;17(20):5525-8.
2007: Robert I Higuchi; Anthony W Thompson; Jyun-Hung Chen; Thomas R Caferro; Marquis L Cummings; Charlotte P Deckhut; Mark E Adams; Christopher M Tegley; James P Edwards; Francisco J López; E Adam Kallel; Donald S Karanewsky; William T Schrader; Keith B Marschke; Lin Zhi
Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.
Bioorganic & medicinal chemistry letters 2007;17(19):5442-6.
2007: Navin L Rao; Paul J Dunford; Xiaohua Xue; Xiaohui Jiang; Katherine A Lundeen; Fawn Coles; Jason P Riley; Kacy N Williams; Cheryl A Grice; James P Edwards; Lars Karlsson; Anne M Fourie
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1154-60.
2007: Robert I Higuchi; Kristen L Arienti; Francisco J López; Neelakandha S Mani; Dale E Mais; Thomas R Caferro; Yun Oliver Long; Todd K Jones; James P Edwards; Lin Zhi; William T Schrader; Andrés Negro-Vilar; Keith B Marschke
Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.
Journal of medicinal chemistry 2007;50(10):2486-96.
2006: Alice Lee-Dutra; Kristen L Arienti; Daniel J Buzard; Michael D Hack; Haripada Khatuya; Pragnya J Desai; Steven Nguyen; Robin Thurmond; Lars Karlsson; James P Edwards; J Guy Breitenbucher
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.
Bioorganic & medicinal chemistry letters 2006;16(23):6043-8.
2006: Cheryl A Grice; Kevin Tays; Haripada Khatuya; Darin J Gustin; Christopher Butler; Jianmei Wei; Clark A Sehon; Siquan Sun; Yin Gu; Wendy Jiang; Robin Thurmond; Lars Karlsson; James P Edwards
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(8):2209-12.
2005: Jennifer D Venable; Hui Cai; Wenying Chai; Curt A Dvorak; Cheryl A Grice; JIll Jablonowski; Chandra R Shah; Annette K Kwok; Kiev S Ly; Barbara Pio; Jianmei Wei; Pragnya J Desai; Wendy Jiang; Steven Nguyen; Ping Ling; Sandy J Wilson; Paul J Dunford; Robin Thurmond; Timothy W Lovenberg; Lars Karlsson; Nicholas I Carruthers; James P Edwards
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Journal of medicinal chemistry 2005;48(26):8289-98.
2005: Robin Thurmond; Siquan Sun; Lars Karlsson; James P Edwards
Cathepsin S inhibitors as novel immunomodulators.
Current opinion in investigational drugs (London, England : 2000) 2005;6(5):473-82.
2005: Darin J Gustin; Clark A Sehon; Jianmei Wei; Hui Cai; Steven P Meduna; Haripada Khatuya; Siquan Sun; Yin Gu; Wendy Jiang; Robin Thurmond; Lars Karlsson; James P Edwards
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(6):1687-91.
2004: Robin Thurmond; Mary Pat Beavers; Hui Cai; Steven P Meduna; Darin J Gustin; Siquan Sun; Harold J Almond; Lars Karlsson; James P Edwards
Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.
Journal of medicinal chemistry 2004;47(20):4799-801.
2004: Ping Ling; Karen Ngo; Steven Nguyen; Robin Thurmond; James P Edwards; Lars Karlsson; Wai-Ping Fung-Leung
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
British journal of pharmacology 2004;142(1):161-71.
2004: Robin Thurmond; Pragnya J Desai; Paul J Dunford; Wai-Ping Fung-Leung; Claudia L Hofstra; Wendy Jiang; Steven Nguyen; Jason P Riley; Siquan Sun; Kacy N Williams; James P Edwards; Lars Karlsson
A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
The Journal of pharmacology and experimental therapeutics 2004;309(1):404-13.
2004: Robin Thurmond; Siquan Sun; Clark A Sehon; Sherry M Baker; Hui Cai; Yin Gu; Wendy Jiang; Jason P Riley; Kacy N Williams; James P Edwards; Lars Karlsson
Identification of a potent and selective noncovalent cathepsin S inhibitor.
The Journal of pharmacology and experimental therapeutics 2004;308(1):268-76.
2003: Lin Zhi; Christopher M Tegley; Barbara Pio; James P Edwards; Mehrnouch Motamedi; Todd K Jones; Keith B Marschke; Dale E Mais; Boris Risek; William T Schrader
5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.
Journal of medicinal chemistry 2003;46(19):4104-12.
2003: JIll Jablonowski; Cheryl A Grice; Wenying Chai; Curt A Dvorak; Jennifer D Venable; Annette K Kwok; Kiev S Ly; Jianmei Wei; Sherry M Baker; Pragnya J Desai; Wendy Jiang; Sandy J Wilson; Robin Thurmond; Lars Karlsson; James P Edwards; Timothy W Lovenberg; Nicholas I Carruthers
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Journal of medicinal chemistry 2003;46(19):3957-60.
2003: Lin Zhi; Josef D Ringgenberg; James P Edwards; Christopher M Tegley; Sarah J West; Barbara Pio; Mehrnouch Motamedi; Todd K Jones; Keith B Marschke; Dale E Mais; William T Schrader
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Bioorganic & medicinal chemistry letters 2003;13(12):2075-8.
2003: Lin Zhi; Christopher M Tegley; Barbara Pio; James P Edwards; Todd K Jones; Keith B Marschke; Dale E Mais; Boris Risek; William T Schrader
Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.
Bioorganic & medicinal chemistry letters 2003;13(12):2071-4.
2000: JW Kong; Lawrence G Hamann; D A Ruppar; James P Edwards; Keith B Marschke; Todd K Jones
Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6-g]quin olines.
Bioorganic & medicinal chemistry letters 2000;10(5):411-4.
1999: Robert I Higuchi; James P Edwards; Thomas R Caferro; J D Ringgenberg; JW Kong; Lawrence G Hamann; Kristen L Arienti; Keith B Marschke; R L Davis; Luc J Farmer; Todd K Jones
4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: potent, nonsteroidal androgen receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(9):1335-40.
1999: James P Edwards; Robert I Higuchi; D T Winn; CL Pooley; Thomas R Caferro; Lawrence G Hamann; Lin Zhi; Keith B Marschke; ME Goldman; Todd K Jones
Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.
Bioorganic & medicinal chemistry letters 1999;9(7):1003-8.
1998: Lin Zhi; Christopher M Tegley; James P Edwards; Sarah J West; Keith B Marschke; MM Gottardis; Dale E Mais; Todd K Jones
5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.
Bioorganic & medicinal chemistry letters 1998;8(23):3365-70.
1998: Lawrence G Hamann; D T Winn; CL Pooley; Christopher M Tegley; Sarah J West; Luc J Farmer; Lin Zhi; James P Edwards; Keith B Marschke; Dale E Mais; ME Goldman; Todd K Jones
Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.
Bioorganic & medicinal chemistry letters 1998;8(19):2731-6.
1998: CL Pooley; James P Edwards; ME Goldman; M W Wang; Keith B Marschke; Diane L Crombie; Todd K Jones
Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.
Journal of medicinal chemistry 1998;41(18):3461-6.
1998: James P Edwards; Lin Zhi; CL Pooley; Christopher M Tegley; Sarah J West; M W Wang; MM Gottardis; C Pathirana; William T Schrader; Todd K Jones
Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.
Journal of medicinal chemistry 1998;41(15):2779-85.
1998: James P Edwards; Sarah J West; CL Pooley; Keith B Marschke; Luc J Farmer; Todd K Jones
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.
Bioorganic & medicinal chemistry letters 1998;8(7):745-50.
1998: Lawrence G Hamann; Robert I Higuchi; Lin Zhi; James P Edwards; X N Wang; Keith B Marschke; JW Kong; Luc J Farmer; Todd K Jones
Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.
Journal of medicinal chemistry 1998;41(4):623-39.
1998: James P Edwards; Sarah J West; Keith B Marschke; Dale E Mais; MM Gottardis; Todd K Jones
5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.
Journal of medicinal chemistry 1998;41(3):303-10.