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Peter Edwards

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Thomas Q de Aguiar Vallim; Elizabeth J Tarling; Peter A Edwards
Pleiotropic roles of bile acids in metabolism.
Brian J Bennett; Rosanne Crooke; Peter A Edwards; Mark Graham; Jill Gregory; Stanley L Hazen; Richard Lee; Yonghong Meng; Diana M Shih; Zeneng Wang; Thomas Q de Aguiar Vallim; Hooman Allayee; Aldons J Lusis
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Elizabeth J Tarling; Peter A Edwards
ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.

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All Publications

2013: Thomas Q de Aguiar Vallim; Elizabeth J Tarling; Peter A Edwards
Pleiotropic roles of bile acids in metabolism.
Cell metabolism 2013;17(5):657-69.
2013: Brian J Bennett; Rosanne Crooke; Peter A Edwards; Mark Graham; Jill Gregory; Stanley L Hazen; Richard Lee; Yonghong Meng; Diana M Shih; Zeneng Wang; Thomas Q de Aguiar Vallim; Hooman Allayee; Aldons J Lusis
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Cell metabolism 2013;17(1):49-60.
2011: Elizabeth J Tarling; Peter A Edwards
ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(49):19719-24.
2010: Florence Ying Lee; Thomas Quad de Aguiar Vallim; Hansook Kim Chong; Yanqiao Zhang; Yaping Liu; Stacey A Jones; Timothy F Osborne; Peter A Edwards
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.
Molecular endocrinology (Baltimore, Md.) 2010;24(8):1626-36.
2010: Elizabeth J Tarling; Dragana D Bojanic; Rajendra K Tangirala; Xuping Wang; Anita Lovgren-Sandblom; Aldons J Lusis; Ingemar Bjorkhem; Peter A Edwards
Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(6):1174-80.
2010: Dragana D Bojanic; Paul T Tarr; Greg D Gale; Desmond J Smith; Dean Bok; Bryan Chen; Steven Nusinowitz; Anita Lövgren-Sandblom; Ingemar Björkhem; Peter A Edwards
Differential expression and function of ABCG1 and ABCG4 during development and aging.
Journal of lipid research 2010;51(1):169-81.
2009: Thomas Quad de Aguiar Vallim; Peter A Edwards
Bile acids have the gall to function as hormones.
Cell metabolism 2009;10(3):162-4.
2009: Paul T Tarr; Elizabeth J Tarling; Dragana D Bojanic; Peter A Edwards; Angel Baldan
Emerging new paradigms for ABCG transporters.
Biochimica et biophysica acta 2009;1791(7):584-93.
2009: Angel Baldan; Dragana D Bojanic; Peter A Edwards
The ABCs of sterol transport.
Journal of lipid research 2009;50 Suppl():S80-5.
2008: Steven J Bensinger; Michelle N Bradley; Sean B Joseph; Noam Zelcer; edith janssen; Mary Ann Hausner; Roger Shih; John S Parks; Peter A Edwards; Beth D Jamieson; Peter Tontonoz
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Cell 2008;134(1):97-111.
2008: Angel Baldan; Aldrin Gomes; Peipei Ping; Peter A Edwards
Loss of ABCG1 results in chronic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3560-8.
2008: Yanqiao Zhang; Peter A Edwards
FXR signaling in metabolic disease.
FEBS letters 2008;582(1):10-8.
2008: Paul T Tarr; Peter A Edwards
ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.
Journal of lipid research 2008;49(1):169-82.
2007: Hans Lee; Melissa L Hubbert; Timothy F Osborne; Katherine Woodford; Noa Zerangue; Peter A Edwards
Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha.
The Journal of biological chemistry 2007;282(30):21653-61.
2007: Melissa L Hubbert; Yanqiao Zhang; Florence Y Lee; Peter A Edwards
Regulation of hepatic Insig-2 by the farnesoid X receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1359-69.
2006: Florence Y Lee; Hans Lee; Melissa L Hubbert; Peter A Edwards; Yanqiao Zhang
FXR, a multipurpose nuclear receptor.
Trends in biochemical sciences 2006;31(10):572-80.
2006: Angel Baldan; Liming Pei; Richard Lee; Paul Tarr; Rajendra K Tangirala; Michael M Weinstein; Joy Frank; Andrew C Li; Peter Tontonoz; Peter A Edwards
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2301-7.
2006: Yanqiao Zhang; Xuping Wang; Charisse Vales; Florence Ying Lee; Hans Lee; Aldons J Lusis; Peter A Edwards
FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2316-21.
2006: Angel Baldan; Paul Tarr; Charisse Vales; Joy Frank; Thomas K Shimotake; Samuel Hawgood; Peter A Edwards
Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis.
The Journal of biological chemistry 2006;281(39):29401-10.
2006: Angel Baldan; Paul Tarr; Richard Lee; Peter A Edwards
ATP-binding cassette transporter G1 and lipid homeostasis.
Current opinion in lipidology 2006;17(3):227-32.
2006: Diana M Shih; Heidi R Kast-Woelbern; Jack Wong; Yu-Rong Xia; Peter A Edwards; Aldons J Lusis
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.
Journal of lipid research 2006;47(2):384-92.
2006: Yanqiao Zhang; Florence Ying Lee; Gabriel Barrera; Hans Lee; Charisse Vales; Frank J Gonzalez; Timothy M Willson; Peter A Edwards
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1006-11.
2006: Hans Lee; Yanqiao Zhang; Florence Y Lee; Stanley F Nelson; Frank J Gonzalez; Peter A Edwards
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.
Journal of lipid research 2006;47(1):201-14.
2005: Florence Y Lee; Heidi R Kast-Woelbern; Jenny Chang; Guizhen Luo; Stacey A Jones; Michael C Fishbein; Peter A Edwards
Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers.
The Journal of biological chemistry 2005;280(36):31792-800.
2005: Satoko Arai; John M Shelton; Mingyi Chen; Michelle N Bradley; Antonio Castrillo; Angie L Bookout; Puiying A Mak; Peter A Edwards; David J Mangelsdorf; Peter Tontonoz; Toru Miyazaki
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.
Cell metabolism 2005;1(3):201-13.
2005: Andrew M Anisfeld; Heidi R Kast-Woelbern; Hans Lee; Yanqiao Zhang; Florence Y Lee; Peter A Edwards
Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.
Journal of lipid research 2005;46(3):458-68.
2005: Matthew A Kennedy; Gabriel C Barrera; Kotoka Nakamura; Angel Baldan; Paul Tarr; Michael C Fishbein; Joy Frank; Omar L Francone; Peter A Edwards
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
Cell metabolism 2005;1(2):121-31.
2004: Kotoka Nakamura; Matthew A Kennedy; Angel Baldan; Dragana D Bojanic; Karen Lyons; Peter A Edwards
Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein.
The Journal of biological chemistry 2004;279(44):45980-9.
2004: Yanqiao Zhang; Lawrence W Castellani; Christopher J Sinal; Frank J Gonzalez; Peter A Edwards
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.
Genes & development 2004;18(2):157-69.
2003: Andrew M Anisfeld; Heidi R Kast-Woelbern; Marie E Meyer; Stacey A Jones; Yanqiao Zhang; Kevin J Williams; Timothy M Willson; Peter A Edwards
Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor.
The Journal of biological chemistry 2003;278(22):20420-8.
2003: Michael Downes; Mark A Verdecia; AJ Roecker; Robert Hughes; John B Hogenesch; Heidi R Kast-Woelbern; Marianne E Bowman; Jean-Luc Ferrer; Andrew M Anisfeld; Peter A Edwards; John M Rosenfeld; Jacqueline G A Alvarez; Joseph P Noel; Kyriacos C Nicolaou; Ronald M Evans
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
Molecular cell 2003;11(4):1079-92.
2003: Yanqiao Zhang; Heidi R Kast-Woelbern; Peter A Edwards
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation.
The Journal of biological chemistry 2003;278(1):104-10.
2002: Puiying A Mak; Heidi R Kast-Woelbern; Andrew M Anisfeld; Peter A Edwards
Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors.
Journal of lipid research 2002;43(12):2037-41.
2002: Puiying A Mak; Bryan A Laffitte; Catherine Desrumaux; Sean B Joseph; Linda K Curtiss; David J Mangelsdorf; Peter Tontonoz; Peter A Edwards
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
The Journal of biological chemistry 2002;277(35):31900-8.
2002: Peter A Edwards; Matthew A Kennedy; Puiying A Mak
LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis.
Vascular pharmacology 2002;38(4):249-56.
2002: Heidi R Kast; Bryan Goodwin; Paul T Tarr; Stacey A Jones; Andrew M Anisfeld; Catherine M Stoltz; Peter Tontonoz; Steven A Kliewer; Timothy M Willson; Peter A Edwards
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The Journal of biological chemistry 2002;277(4):2908-15.
2002: Peter A Edwards; Heidi R Kast; Andrew M Anisfeld
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.
Journal of lipid research 2002;43(1):2-12.
2001: Matthew A Kennedy; A Venkateswaran; Paul T Tarr; Ioannis Xenarios; J Kudoh; N Shimizu; Peter A Edwards
Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein.
The Journal of biological chemistry 2001;276(42):39438-47.
2001: Heidi R Kast; CM Nguyen; Christopher J Sinal; Stacey A Jones; Bryan A Laffitte; Karen Reue; F J Gonzalez; Timothy M Willson; Peter A Edwards
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.
Molecular endocrinology (Baltimore, Md.) 2001;15(10):1720-8.
2001: Heidi R Kast; CM Nguyen; Andrew M Anisfeld; J Ericsson; Peter A Edwards
CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene.
Journal of lipid research 2001;42(8):1266-72.
2001: Ajay Chawla; William A Boisvert; C H Lee; Bryan A Laffitte; Y Barak; Sean B Joseph; Debbie Liao; L Nagy; Peter A Edwards; Linda K Curtiss; Ronald M Evans; Peter Tontonoz
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.
Molecular cell 2001;7(1):161-71.
2000: Peter A Edwards; DE Tabor; Heidi R Kast; A Venkateswaran
Regulation of gene expression by SREBP and SCAP.
Biochimica et biophysica acta 2000;1529(1-3):103-13.
2000: A Venkateswaran; Bryan A Laffitte; Sean B Joseph; Puiying A Mak; DAMIEN WILPITZ; Peter A Edwards; Peter Tontonoz
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12097-102.
2000: A Venkateswaran; Joyce J Repa; Jean-Marc Lobaccaro; A Bronson; David J Mangelsdorf; Peter A Edwards
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols.
The Journal of biological chemistry 2000;275(19):14700-7.
2000: Bryan A Laffitte; Heidi R Kast; CM Nguyen; Ann Marie Zavacki; David D Moore; Peter A Edwards
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.
The Journal of biological chemistry 2000;275(14):10638-47.
1999: DE Tabor; JB Kim; Bruce M Spiegelman; Peter A Edwards
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
The Journal of biological chemistry 1999;274(29):20603-10.
1999: J Ericsson; A Usheva; Peter A Edwards
YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes.
The Journal of biological chemistry 1999;274(20):14508-13.
1999: Peter A Edwards; J Ericsson
Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway.
Annual review of biochemistry 1999;68():157-85.
1998: Peter A Edwards; J Ericsson
Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease.
Current opinion in lipidology 1998;9(5):433-40.
1998: J Ericsson; J M Greene; K C Carter; BK Shell; DR Duan; C Florence; Peter A Edwards
Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression.
Journal of lipid research 1998;39(9):1731-9.
1998: DE Tabor; JB Kim; Bruce M Spiegelman; Peter A Edwards
Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
The Journal of biological chemistry 1998;273(34):22052-8.
1998: J Ericsson; Peter A Edwards
CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription.
The Journal of biological chemistry 1998;273(28):17865-70.
1998: SM Jackson; J Ericsson; R Mantovani; Peter A Edwards
Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein.
Journal of lipid research 1998;39(4):767-76.
1998: DE Tabor; Yu-Rong Xia; Margarete Mehrabian; Peter A Edwards; Aldons J Lusis
A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse chromosome 19.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(4):341-2.
1998: Carrie L Welch; Yu-Rong Xia; Peter A Edwards; Aldons J Lusis; J Ericsson
Assignment of Gpam to distal mouse chromosome 19 by linkage analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):93.
1997: J Ericsson; SM Jackson; JB Kim; Bruce M Spiegelman; Peter A Edwards
Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
The Journal of biological chemistry 1997;272(11):7298-305.
1997: SM Jackson; J Ericsson; Peter A Edwards
Signaling molecules derived from the cholesterol biosynthetic pathway.
Sub-cellular biochemistry 1997;28():1-21.
1996: J Ericsson; SM Jackson; Peter A Edwards
Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene.
The Journal of biological chemistry 1996;271(40):24359-64.
1996: SM Jackson; J Ericsson; J E Metherall; Peter A Edwards
Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells.
Journal of lipid research 1996;37(8):1712-21.
1996: J Ericsson; SM Jackson; B C Lee; Peter A Edwards
Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):945-50.
1995: SM Jackson; J Ericsson; T F Osborne; Peter A Edwards
NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes.
The Journal of biological chemistry 1995;270(37):21445-8.
1994: D H Spear; J Ericsson; SM Jackson; Peter A Edwards
Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase.
The Journal of biological chemistry 1994;269(40):25212-8.
1994: C C Correll; L Ng; Peter A Edwards
Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry 1994;269(26):17390-3.
1994: C C Correll; Peter A Edwards
Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro.
The Journal of biological chemistry 1994;269(1):633-8.
1993: A Joly; Peter A Edwards
Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.
The Journal of biological chemistry 1993;268(36):26983-9.
1992: P F Marrero; C D Poulter; Peter A Edwards
Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity.
The Journal of biological chemistry 1992;267(30):21873-8.
1992: D H Spear; S Y Kutsunai; C C Correll; Peter A Edwards
Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene.
The Journal of biological chemistry 1992;267(20):14462-9.
1992: R W Bork; K L Svenson; Margarete Mehrabian; A J Lusis; Alan M Fogelman; Peter A Edwards
Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(7):800-6.
1992: Peter A Edwards; M N Ashby; D H Spear; P F Marrero; A Joly; G Popják
Polyisoprenoid synthesis and metabolism.
Biochemical Society transactions 1992;20(2):475-9.
1992: John Hwa; S Zollman; Craig H Warden; B A Taylor; Peter A Edwards; Alan M Fogelman; A J Lusis
Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.
Journal of lipid research 1992;33(5):711-25.
1992: M N Ashby; S Y Kutsunai; Sharon H Ackerman; Alexander Tzagoloff; Peter A Edwards
COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase.
The Journal of biological chemistry 1992;267(6):4128-36.
1992: D J Wilkin; Peter A Edwards
Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.
The Journal of biological chemistry 1992;267(4):2831-6.
1991: A Joly; G Popják; Peter A Edwards
In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues.
The Journal of biological chemistry 1991;266(21):13495-8.
1991: J H Teruya; E C Salido; Peter A Edwards; Catherine F Clarke
Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells.
Biology of reproduction 1991;44(4):663-71.
1990: M N Ashby; Peter A Edwards
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
The Journal of biological chemistry 1990;265(22):13157-64.
1990: J H Teruya; S Y Kutsunai; D H Spear; Peter A Edwards; Catherine F Clarke
Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.
Molecular and cellular biology 1990;10(5):2315-26.
1990: D J Wilkin; S Y Kutsunai; Peter A Edwards
Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.
The Journal of biological chemistry 1990;265(8):4607-14.
1989: Peter A Edwards; S M Grundy
Hepatic cholesterol and lipoprotein conference. Report of a conference.
Journal of lipid research 1989;30(10):1653-9.
1989: C Heinzmann; Catherine F Clarke; I Klisak; T Mohandas; RS Sparkes; Peter A Edwards; A J Lusis
Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase.
Genomics 1989;5(3):493-500.
1989: D S Rosser; M N Ashby; J L Ellis; Peter A Edwards
Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells.
The Journal of biological chemistry 1989;264(21):12653-6.
1989: M N Ashby; Peter A Edwards
Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase.
The Journal of biological chemistry 1989;264(1):635-40.
1988: Alan M Fogelman; Brian J Van Lenten; Craig H Warden; Margaret Haberland; Peter A Edwards
Macrophage lipoprotein receptors.
Journal of cell science. Supplement 1988;9():135-49.
1987: Catherine F Clarke; R D Tanaka; K Svenson; M Wamsley; Alan M Fogelman; Peter A Edwards
Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway.
Molecular and cellular biology 1987;7(9):3138-46.
1986: Mohamad Navab; G P Hough; Judith A Berliner; J A Frank; Alan M Fogelman; Margaret Haberland; Peter A Edwards
Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.
The Journal of clinical investigation 1986;78(2):389-97.
1986: Peter A Edwards; S F Lan; Alan M Fogelman
The effect of glucagon on the synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Journal of lipid research 1986;27(4):398-403.
1986: Brian J Van Lenten; Alan M Fogelman; Margaret Haberland; Peter A Edwards
The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2704-8.
1985: Brian J Van Lenten; Alan M Fogelman; R L Jackson; S Shapiro; Margaret Haberland; Peter A Edwards
Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages.
The Journal of biological chemistry 1985;260(15):8783-8.
1985: J P Phelan; Brian J Van Lenten; Alan M Fogelman; C Kean; Margaret Haberland; Peter A Edwards
Notes on the breeding of the WHHL rabbit: an animal model of familial hypercholesterolemia.
Journal of lipid research 1985;26(6):776-8.
1985: Brian J Van Lenten; Alan M Fogelman; J Seager; E Ribi; Margaret Haberland; Peter A Edwards
Bacterial endotoxin selectively prevents the expression of scavenger-receptor activity on human monocyte-macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1985;134(6):3718-21.
1984: Peter A Edwards; S F Lan; Alan M Fogelman
High density lipoproteins and lecithin dispersions increase the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by increasing the rate of synthesis and decreasing the rate of degradation of the enzyme.
The Journal of biological chemistry 1984;259(13):8190-4.
1984: D P Baker; Brian J Van Lenten; Alan M Fogelman; Peter A Edwards; C Kean; Judith A Berliner
LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.
Arteriosclerosis (Dallas, Tex.) 1984;4(3):248-55.
1983: R D Tanaka; Peter A Edwards; S F Lan; Alan M Fogelman
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol.
The Journal of biological chemistry 1983;258(21):13331-9.
1983: Alan M Fogelman; J Seager; J E Groopman; Judith A Berliner; Margaret Haberland; Peter A Edwards; D W Golde
Lymphokines secreted by an established lymphocyte line modulate receptor-mediated endocytosis in macrophages derived from human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(5):2368-73.
1983: Peter A Edwards; S F Lan; Alan M Fogelman
Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.
The Journal of biological chemistry 1983;258(17):10219-22.
1983: Peter A Edwards; S F Lan; R D Tanaka; Alan M Fogelman
Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.
The Journal of biological chemistry 1983;258(12):7272-5.
1983: Catherine F Clarke; Peter A Edwards; S F Lan; R D Tanaka; Alan M Fogelman
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(11):3305-8.
1983: Brian J Van Lenten; Alan M Fogelman; M M Hokom; L Benson; Margaret Haberland; Peter A Edwards
Regulation of the uptake and degradation of beta-very low density lipoprotein in human monocyte macrophages.
The Journal of biological chemistry 1983;258(8):5151-7.
1982: Alan M Fogelman; M M Hokom; Margaret Haberland; R D Tanaka; Peter A Edwards
Lipoprotein regulation of cholesterol metabolism in macrophages derived from human monocytes.
The Journal of biological chemistry 1982;257(23):14081-6.
1982: R D Tanaka; Peter A Edwards; S F Lan; E M Knöppel; Alan M Fogelman
The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Journal of lipid research 1982;23(7):1026-31.
1982: R D Tanaka; Peter A Edwards; S F Lan; E M Knöppel; Alan M Fogelman
Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver.
Journal of lipid research 1982;23(4):523-30.
1982: Alan M Fogelman; J Seager; Margaret Haberland; M Hokom; R Tanaka; Peter A Edwards
Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(3):922-6.
1981: Alan M Fogelman; Margaret Haberland; J Seager; M Hokom; Peter A Edwards
Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.
Journal of lipid research 1981;22(7):1131-41.
1981: I Shechter; Alan M Fogelman; Margaret Haberland; J Seager; M Hokom; Peter A Edwards
The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages.
Journal of lipid research 1981;22(1):63-71.
1980: Alan M Fogelman; I Shechter; J Seager; M Hokom; J S Child; Peter A Edwards
Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2214-8.