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Robert Edwards

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Nazeeha Hasan; Peter McColgan; Paul Bentley; Robert J Edwards; Pankaj Sharma
Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review.
Sven van Eijl; Zheying Zhu; John Cupitt; Ellen Fritsche; Magdalena Gierula; Christine Götz; Robert J Edwards
Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling.
Vahitha B Abdul-Salam; John Wharton; John Cupitt; Mark Berryman; Robert J Edwards; Martin R Wilkins
Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension.

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All Publications

2012: Nazeeha Hasan; Peter McColgan; Paul Bentley; Robert J Edwards; Pankaj Sharma
Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review.
British journal of clinical pharmacology 2012;74(2):230-40.
2012: Sven van Eijl; Zheying Zhu; John Cupitt; Ellen Fritsche; Magdalena Gierula; Christine Götz; Robert J Edwards
Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling.
PloS one 2012;7(7):e41721.
2010: Vahitha B Abdul-Salam; John Wharton; John Cupitt; Mark Berryman; Robert J Edwards; Martin R Wilkins
Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension.
Circulation 2010;122(20):2058-67.
2010: Prathiba Kurupati; Claire Turner; Ioanna Tziona; Richard A Lawrenson; Faraz M Alam; Mahrokh Nohadani; Gordon W Stamp; Annelies S Zinkernagel; Victor Nizet; Robert J Edwards; Shiranee Sriskandan
Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract.
Molecular microbiology 2010;76(6):1387-97.
2010: Vahitha B Abdul-Salam; Punit Ramrakha; Unni Krishnan; David R Owen; Joseph Shalhoub; Alun H Davies; Tjun Y Tang; Jonathan H Gillard; Joseph J Boyle; Martin R Wilkins; Robert J Edwards
Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(5):1027-33.
2009: Claire Turner; Prathiba Kurupati; Siouxsie Wiles; Robert J Edwards; Shiranee Sriskandan
Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi.
Vaccine 2009;27(36):4923-9.
2009: Zheying Zhu; Robert J Edwards; Alan R Boobis
Increased expression of histone proteins during estrogen-mediated cell proliferation.
Environmental health perspectives 2009;117(6):928-34.
2008: Zheying Zhu; Robert J Edwards; Alan R Boobis
Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity).
Toxicology letters 2008;181(2):93-103.
2008: Zheying Zhu; Alan R Boobis; Robert J Edwards
Identification of estrogen-responsive proteins in MCF-7 human breast cancer cells using label-free quantitative proteomics.
Proteomics 2008;8(10):1987-2005.
2007: Robert J Edwards; Amanda Wrigley; Zhonghu Bai; Michaela Bateman; Hugh H Russell; Stephen Murray; Huafeng Lu; Graham W Taylor; Alan R Boobis; Shiranee Sriskandan
C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity.
Proteomics 2007;7(9):1364-72.
2006: Vahitha B Abdul-Salam; Gideon A Paul; J Omar Ali; Simon R Gibbs; Dinah Rahman; Graham W Taylor; Martin R Wilkins; Robert J Edwards
Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension.
Proteomics 2006;6(7):2286-94.
2006: Pamela Vig; Francesco P Russo; Robert J Edwards; Paul J Tadrous; Nicholas A Wright; Howard Thomas; Stuart McDonald; Stuart J Forbes
The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.
Hepatology (Baltimore, Md.) 2006;43(2):316-24.
2006: Robert J Edwards
Targeting antipeptide antibodies toward cytochrome P450 enzymes.
Methods in molecular biology (Clifton, N.J.) 2006;320():173-82.
2005: Robert J Edwards; Graham W Taylor; Melissa Ferguson; Stephen Murray; Nigel Rendell; Amanda Wrigley; Zhonghu Bai; Joseph Boyle; Simon J Finney; Angus Jones; Hugh H Russell; Claire Turner; Jonathan Cohen; Lee Faulkner; Shiranee Sriskandan
Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.
The Journal of infectious diseases 2005;192(5):783-90.
2005: Karen A O'Leary; Robert J Edwards; Margaret M Town; Alan R Boobis
Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon.
Pharmacogenetics and genomics 2005;15(1):51-60.
2004: Min Fang; Robert J Edwards; Michael Bartlet-Jones; Graham W Taylor; Stephen Murray; Alan R Boobis
Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure.
Carcinogenesis 2004;25(6):1053-62.
2003: Robert J Edwards; Alan R Boobis; Donald S Davies
A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(12):1476-80.
2003: Laura Fabrizi; Graham W Taylor; Benito Cañas; Alan R Boobis; Robert J Edwards
Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B.
Chemical research in toxicology 2003;16(3):266-75.
2003: Robert J Edwards; Roger J Price; Patricia S Watts; Anthony B Renwick; J Michael Tredger; Alan R Boobis; Brian G Lake
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):282-8.
2002: Zheying Zhu; Sharon A M Hotchkiss; Alan R Boobis; Robert J Edwards
Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes.
Biochemical and biophysical research communications 2002;297(1):65-70.
2001: W A Kappers; Robert J Edwards; Stephen Murray; Alan R Boobis
Diazinon is activated by CYP2C19 in human liver.
Toxicology and applied pharmacology 2001;177(1):68-76.
2001: TG Schulz; Renate Thiel; Diether Neubert; P J Brassil; T Schulz-Utermoehl; Alan R Boobis; Robert J Edwards
Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies.
Biochimica et biophysica acta 2001;1546(1):143-55.
2001: Stephen Murray; A O Odupitan; B P Murray; Alan R Boobis; Robert J Edwards
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(3):135-51.
2001: L Fabrizi; Graham W Taylor; Robert J Edwards; Alan R Boobis
Adducts of the chloroform metabolite phosgene.
Advances in experimental medicine and biology 2001;500():129-32.
2000: Anthony B Renwick; Patricia S Watts; Robert J Edwards; PT Barton; I Guyonnet; Roger J Price; J Michael Tredger; Olavi Pelkonen; Alan R Boobis; Brian G Lake
Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1202-9.
2000: TG Schulz; FA Wiebel; Ricarda Thier; Diether Neubert; Donald S Davies; Robert J Edwards
Identification of theta-class glutathione S-transferase in liver cytosol of the marmoset monkey.
Archives of toxicology 2000;74(3):133-8.
2000: T Schulz-Utermoehl; Robert J Edwards; Alan R Boobis
Affinity and potency of proinhibitory antipeptide antibodies against CYP2D6 is enhanced using cyclic peptides as immunogens.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(5):544-51.
2000: N J Thatcher; Robert J Edwards; Nick Lemoine; Johannes Doehmer; Donald S Davies
The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy.
Cancer gene therapy 2000;7(4):521-5.
1999: K Watson; Robert J Edwards
HIV-1-trans-activating (Tat) protein: both a target and a tool in therapeutic approaches.
Biochemical pharmacology 1999;58(10):1521-8.
1999: K Watson; Nigel J Gooderham; Donald S Davies; Robert J Edwards
Nucleosomes bind to cell surface proteoglycans.
The Journal of biological chemistry 1999;274(31):21707-13.
1999: T Schulz-Utermoehl; A J Bennett; S Wynne Ellis; Geoffrey T Tucker; Alan R Boobis; Robert J Edwards
Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression.
Pharmacogenetics 1999;9(3):357-66.
1999: K Watson; Nigel J Gooderham; Donald S Davies; Robert J Edwards
Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides.
Biochemical pharmacology 1999;57(7):775-83.
1998: Robert J Edwards; DA Adams; Patricia S Watts; Donald S Davies; Alan R Boobis
Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans.
Biochemical pharmacology 1998;56(3):377-87.
1998: P J Brassil; K Debri; H Nakura; S Kobayashi; Donald S Davies; Robert J Edwards
Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia.
Biochemical pharmacology 1998;56(2):253-7.
1998: TG Schulz; Renate Thiel; Donald S Davies; Robert J Edwards
Identification of CYP2E1 in marmoset monkey.
Biochimica et biophysica acta 1998;1382(2):287-94.
1998: Robert J Edwards
Targeting antipeptide antibodies towards cytochrome P450 enzymes.
Methods in molecular biology (Clifton, N.J.) 1998;107():239-49.
1997: DA Adams; Robert J Edwards; Donald S Davies; Alan R Boobis
Specific inhibition of human CYP1A2 using a targeted antibody.
Biochemical pharmacology 1997;54(1):189-97.
1997: CM Javan; Nigel J Gooderham; Robert J Edwards; Donald S Davies; Sunil Shaunak
Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages.
AIDS research and human retroviruses 1997;13(10):875-80.
1997: Catherine Sarraf; M Horgan; Robert J Edwards; Stuart McDonald
Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice.
International journal of experimental pathology 1997;78(1):49-56.
1996: T G Schulz; D Neubert; Donald S Davies; Robert J Edwards
Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus).
Biochimica et biophysica acta 1996;1298(1):131-40.
1996: Nigel J Gooderham; Stephen Murray; Anthony Lynch; Robert J Edwards; Masoud Yadollahi-Farsani; C Bratt; K J Rich; K Zhao; B P Murray; S Bhadresa; S J Crosbie; Alan R Boobis; Donald S Davies
Heterocyclic amines: evaluation of their role in diet associated human cancer.
British journal of clinical pharmacology 1996;42(1):91-8.
1996: Alan R Boobis; Robert J Edwards; DA Adams; Donald S Davies
Dissecting the function of cytochrome P450.
British journal of clinical pharmacology 1996;42(1):81-9.
1996: T G Schulz; D Neubert; Donald S Davies; Robert J Edwards
Induction of cytochromes P450 by dioxins in liver and lung of marmoset monkeys (Callithrix jacchus).
Advances in experimental medicine and biology 1996;387():443-6.
1996: Alan R Boobis; Nigel J Gooderham; Robert J Edwards; Stephen Murray; Anthony Lynch; Masoud Yadollahi-Farsani; Donald S Davies
Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1996;18():286-302.
1995: K Debri; Alan R Boobis; Donald S Davies; Robert J Edwards
Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
Biochemical pharmacology 1995;50(12):2047-56.
1995: T G Schulz; R Stahlmann; Robert J Edwards; K Debri; Donald S Davies; Diether Neubert
Enoxacin is an inducer of CYP1A2 in rat liver.
Biochemical pharmacology 1995;50(9):1517-20.
1995: K Watson; Robert J Edwards; Sunil Shaunak; D C Parmelee; C Sarraf; Nigel J Gooderham; Donald S Davies
Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells.
Biochemical pharmacology 1995;50(3):299-309.
1995: P J Brassil; Robert J Edwards; Donald S Davies
Expression and distribution of cholesterol 7 alpha-hydroxylase in rat liver.
Biochemical pharmacology 1995;50(3):311-6.
1995: Robert J Edwards; A M Singleton; B P Murray; Donald S Davies; Alan R Boobis
Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes.
Biochemical pharmacology 1995;49(1):39-47.
1995: Alan R Boobis; Nigel J Gooderham; K J Rich; K Zhao; Robert J Edwards; B P Murray; Anthony Lynch; Stephen Murray; Donald S Davies
Enzymatic studies of the activation of heterocyclic food mutagens in man.
Princess Takamatsu symposia 1995;23():134-44.
1994: Sunil Shaunak; Nigel J Gooderham; Robert J Edwards; N Payvandi; C M Javan; N Baggett; J MacDermot; J N Weber; Donald S Davies
Infection by HIV-1 blocked by binding of dextrin 2-sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T-cells.
British journal of pharmacology 1994;113(1):151-8.
1994: Robert J Edwards; B P Murray; Stephen Murray; T Schulz; D Neubert; T W Gant; S S Thorgeirsson; Alan R Boobis; Donald S Davies
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.
Carcinogenesis 1994;15(5):829-36.
1994: K Watson; Robert J Edwards; D C Parmelee; Sunil Shaunak; Nigel J Gooderham; Donald S Davies
Histones located on the plasma membrane of T-cells.
Biochemical Society transactions 1994;22(2):199S.
1994: R A Brooks; Nigel J Gooderham; K Zhao; Robert J Edwards; L A Howard; Alan R Boobis; Douglas J Winton
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.
Cancer research 1994;54(7):1665-71.
1993: Robert J Edwards; B P Murray; A M Singleton; Stephen Murray; Donald S Davies; Alan R Boobis
Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man.
Biochemical pharmacology 1993;46(2):213-20.
1993: K J Rich; J R Foster; Robert J Edwards; Donald S Davies; Alan R Boobis
Ontogenetic development of the distribution of constitutive and 3-methylcholanthrene-induced CYP1A1 and CYP1A2 in rabbit liver.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(6):915-25.
1993: B P Murray; Robert J Edwards; Stephen Murray; A M Singleton; Donald S Davies; Alan R Boobis
Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP.
Carcinogenesis 1993;14(4):585-92.
1993: Robert J Edwards; B P Murray; Stephen Murray; A M Singleton; Donald S Davies; Alan R Boobis
An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2.
Biochimica et biophysica acta 1993;1161(1):38-46.
1992: Robert J Edwards; D Sesardic; B P Murray; A M Singleton; Donald S Davies; Alan R Boobis
Identification of the epitope of a monoclonal antibody which binds to several cytochromes P450 in the CYP1A subfamily.
Biochemical pharmacology 1992;43(8):1737-46.
1992: Robert J Edwards; A B Freeling; D Watson; Donald S Davies
The effect of budesonide and triamcinolone acetonide on hepatic microsomal testosterone metabolism in the rat.
Biochemical pharmacology 1992;43(2):271-82.
1991: Robert J Edwards; A M Singleton; B P Murray; Stephen Murray; Alan R Boobis; Donald S Davies
Identification of a functionally conserved surface region of rat cytochromes P450IA.
The Biochemical journal 1991;278 ( Pt 3)():749-57.
1991: Robert J Edwards; B P Murray; A M Singleton; Alan R Boobis
Orientation of cytochromes P450 in the endoplasmic reticulum.
Biochemistry 1991;30(1):71-6.
1990: Alan R Boobis; D Sesardic; B P Murray; Robert J Edwards; A M Singleton; K J Rich; Stephen Murray; Rafael de la Torre; Jordi Segura; Olavi Pelkonen
Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(11):1139-61.
1990: Robert J Edwards; A M Singleton; B P Murray; D Sesardic; K J Rich; Donald S Davies; Alan R Boobis
An anti-peptide antibody targeted to a specific region of rat cytochrome P-450IA2 inhibits enzyme activity.
The Biochemical journal 1990;266(2):497-504.
1990: D Sesardic; K J Cole; Robert J Edwards; Donald S Davies; P E Thomas; W Levin; Alan R Boobis
The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues.
Biochemical pharmacology 1990;39(3):499-506.
1990: D Sesardic; Robert J Edwards; Donald S Davies; P E Thomas; W Levin; Alan R Boobis
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat.
Biochemical pharmacology 1990;39(3):489-98.
1989: K J Rich; Robert J Edwards; J R Foster; Donald S Davies; Alan R Boobis
Ontogeny of expression, inducibility and distribution of cytochromes P-450 forms 4 and 6 in rabbit liver.
Biochemical Society transactions 1989;17(6):1023-4.
1989: Robert J Edwards; B P Murray; A M Singleton; Donald S Davies; Alan R Boobis
Identification of surface regions of cytochromes P-450 using anti-peptide antibodies.
Biochemical Society transactions 1989;17(6):1022-3.
1989: D Sesardic; K J Rich; Robert J Edwards; Donald S Davies; Alan R Boobis
Selective destruction of cytochrome P-450d and associated monooxygenase activity by carbon tetrachloride in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1989;19(7):795-811.
1989: Robert J Edwards; B P Murray; Alan R Boobis; Donald S Davies
Identification and location of alpha-helices in mammalian cytochromes P450.
Biochemistry 1989;28(9):3762-70.
1989: Robert J Edwards; A M Singleton; Alan R Boobis; Donald S Davies
Cross-reaction of antibodies to coupling groups used in the production of anti-peptide antibodies.
Journal of immunological methods 1989;117(2):215-20.
1988: D Sesardic; Alan R Boobis; Robert J Edwards; Donald S Davies
A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.
British journal of clinical pharmacology 1988;26(4):363-72.
1988: Robert J Edwards; A M Singleton; D Sesardic; Alan R Boobis; Donald S Davies
Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat.
Biochemical pharmacology 1988;37(19):3735-41.