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Thomas Efferth

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Ji Li; Meng Luo; Chun-Jian Zhao; Yuan-Gang Zu; Thomas Efferth; Cheng-Bo Gu; Yu-Jie Fu
Aqueous enzymatic process assisted by microwave extraction of oil from yellow horn (Xanthoceras sorbifolia Bunge.) seed kernels and its quality evaluation.
Lu Liang; Meng Luo; Wei Wang; Chunjian Zhao; Yuangang Zu; Yujie Fu; Chengbo Gu; Chunying Li; Thomas Efferth
Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.
Gerard R Rutteman; Bart Spee; Suzanne A Erich; Lawrence Fleckenstein; Guy C M Grinwis; Cheryl A London; Jan A Mol; Thomas Efferth
Safety and Efficacy Field Study of Artesunate for Dogs with Non-resectable Tumours.

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2013: Ji Li; Meng Luo; Chun-Jian Zhao; Yuan-Gang Zu; Thomas Efferth; Cheng-Bo Gu; Yu-Jie Fu
Aqueous enzymatic process assisted by microwave extraction of oil from yellow horn (Xanthoceras sorbifolia Bunge.) seed kernels and its quality evaluation.
Food chemistry 2013;138(4):2152-8.
2013: Lu Liang; Meng Luo; Wei Wang; Chunjian Zhao; Yuangang Zu; Yujie Fu; Chengbo Gu; Chunying Li; Thomas Efferth
Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.
Toxicology letters 2013;219(3):254-61.
2013: Gerard R Rutteman; Bart Spee; Suzanne A Erich; Lawrence Fleckenstein; Guy C M Grinwis; Cheryl A London; Jan A Mol; Thomas Efferth
Safety and Efficacy Field Study of Artesunate for Dogs with Non-resectable Tumours.
Anticancer research 2013;33(5):1819-27.
2013: Victor Kuete; Marlyse L Moungang; Tetsuya Murayama; Bonaventure T Ngadjui; Bathelemy Ngameni; Michel F Tala; Patricia D Tchakam; Hippolyte K Wabo; Benjamin Wiench; Thomas Efferth
Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2',5,6'-tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2013;20(6):528-36.
2013: Richard E Kast; Daniel Keizman; Kirsi Ketola; Alireza Khoshnevisan; Nicolas Magné; Christine Marosi; Kerrie McDonald; Miguel Muñoz; Ameya Paranjpe; Mohammad H Pourgholami; Iacopo Sardi; Avishay Sella; Kalkunte S Srivenugopal; Marco Tuccori; Weiguang Wang; Christian R Wirtz; John A Boockvar; Ansgar Brüning; Francesco Cappello; Wen-Wei Chang; Boris Cvek; Q Ping Dou; Alfonso Duenas-Gonzalez; Thomas Efferth; Daniele Focosi; Seyed H Ghaffari; Georg Karpel-Massler; Marc-Eric Halatsch
A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.
Oncotarget 2013;4(4):502-30.
2013: Anne Mahringer; Gert Fricker; Karin Ardjomand-Woelkart; Rudolf Bauer; Thomas Efferth
Alkamides from Echinacea angustifolia Interact with P-glycoprotein of primary brain capillary endothelial cells isolated from porcine brain blood vessels.
Planta medica 2013;79(3-4):214-8.
2013: Zuo-Fu Wei; Chun-Jian Zhao; Yuan-Gang Zu; Thomas Efferth; Cheng-Bo Gu; Chun-Ying Li; Meng Luo; Wei Wang; Yu-Jie Fu
UV-induced changes of active components and antioxidant activity in postharvest pigeon pea [Cajanus cajan (L.) Millsp.] leaves.
Journal of agricultural and food chemistry 2013;61(6):1165-71.
2013: Yao Sun; Wei Wang; Yuangang Zu; Thomas Efferth; Chang Gao; Chengbo Gu; Ji Li; Meng Luo; Yujie Fu
Aspidin PB, a phloroglucinol derivative, induces apoptosis in human hepatocarcinoma HepG2 cells by modulating PI3K/Akt/GSK3β pathway.
Chemico-biological interactions 2013;201(1-3):1-8.
2013: Karin von Schwarzenberg; Gerhard Wanner; Romina M Wiedmann; Hans Zischka; Thomas Efferth; Prajakta Oak; Sabine Schulz; Dirk Trauner; Angelika M Vollmar
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.
The Journal of biological chemistry 2013;288(2):1385-96.
2013: Wei Wang; Thomas Efferth; Yujie Fu; Meng Luo; Song Wang; Yuangang Zu
Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid.
International journal of nanomedicine 2013;8():1377-83.
2013: Adriana Ignat Ignat Grozav; Victor Kuete; Luminita Silaghi-Dumitrescu; Thomas Efferth; Luiza Gaina; Valentin Zaharia
Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.
Molecules (Basel, Switzerland) 2013;18(4):4679-88.
2013: Anna Maimer; Andrew Remppis; Stefanie Ringes-Lichtenberg; Falk-Udo Sack; Sven Schröder; Frank Brazkiewicz; Thomas Efferth; Mario Goncalves; Tobias Greten; Henry Johannes Greten
Objectifying acupuncture effects by lung function and numeric rating scale in patients undergoing heart surgery.
Evidence-based complementary and alternative medicine : eCAM 2013;2013():219817.
2013: Alexander Panossian; G Wikman; Rebecca Hamm; Onat Kadioglu; Thomas Efferth
Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells.
Frontiers in neuroscience 2013;7():16.
2013: Tolga Eichhorn; Martin Frank; Corinna Hiller; Kerstin Hirschfelder; R Luise Krauth-Siegel; Rolf Mertens; Rolf Müller; Thomas Efferth
Identification by high-throughput in silico screening of radio-protecting compounds targeting the DNA-binding domain of the tumor suppressor p53.
Cancer genomics & proteomics 2013;10(1):35-45.
2013: Tolga Eichhorn; Martin Frank; Joachim Granzin; R Luise Krauth-Siegel; Wolf-Dieter Lehmann; Rolf Mertens; Thomas Simmet; Dominic Winter; Berthold Büchele; Natalie Dirdjaja; Thomas Efferth
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum.
Biochemical pharmacology 2013;85(1):38-45.
2012: Antoine M Saab; Gianni Sacchetti; Maʼen Zeino; Joachim Arend; Francesco Bernardi; Roberto Gambari; Alessandra Guerrini; Silvia Maietti; Thomas Efferth
Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.
Planta medica 2012;78(18):1927-31.
2012: Joao Pedro Saganha; Tobias Greten; Christoph Doenitz; Thomas Efferth; Henry J Greten
Qigong therapy for physiotherapists suffering from burnout: a preliminary study.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2012;10(11):1233-9.
2012: Tolga Eichhorn; Katharina Deeg; Behzod Z Dolimbek; Thomas Efferth; M Zouhair Atassi
Inhibition in vivo of the activity of botulinum neurotoxin A by small molecules selected by virtual screening.
Toxicon : official journal of the International Society on Toxinology 2012;60(6):1180-90.
2012: Christoph Reiter; Thomas Efferth; Astrid Herrmann; Aysun Çapci; Svetlana B Tsogoeva
New artesunic acid homodimers: potent reversal agents of multidrug resistance in leukemia cells.
Bioorganic & medicinal chemistry 2012;20(18):5637-41.
2012: Ying Zhang; Yuangang Zu; Yujie Fu; Chengbo Gu; Meng Luo; Wei Wang; Liping Yao; Thomas Efferth
Dryofragin, a phloroglucinol derivative, induces apoptosis in human breast cancer MCF-7 cells through ROS-mediated mitochondrial pathway.
Chemico-biological interactions 2012;199(2):129-36.
2012: Claudia Maria Sousa; Tobias Greten; Jorge Machado; Thomas Efferth; Petra Froeschen; Mario Goncalves; Henry J Greten
Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: a feasibility study.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2012;10(8):858-65.
2012: Serkan Sertel; Judith Bauer; Tolga Eichhorn; Kai Hock; Peter K Plinkert; Thomas Efferth
Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
The Journal of nutritional biochemistry 2012;23(8):875-84.
2012: Benjamin Wiench; Tolga Eichhorn; Bernhard Korn; Malte Paulsen; Thomas Efferth
Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics.
Methods (San Diego, Calif.) 2012;57(3):376-82.
2012: Li-Ping Kang; Chao Liu; Yi-Xun Liu; Else Dapat; Thomas Efferth; Tolga Eichhorn; Cheng-Qi Xiong; He-shui Yu; Yang Zhao; Bai-Ping Ma
Polyhydroxylated steroidal glycosides from Paris polyphylla.
Journal of natural products 2012;75(6):1201-5.
2012: Thomas Efferth
Stem cells, cancer stem-like cells, and natural products.
Planta medica 2012;78(10):935-42.
2012: Sebastian Reichert; Vera Reinboldt; Claus Rödel; Thomas Efferth; Stephanie Hehlgans; Franz Rödel
A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012;103(3):394-401.
2012: Tolga Eichhorn; Thomas Efferth
P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs.
Journal of ethnopharmacology 2012;141(2):557-70.
2012: Chiara Righeschi; Anna Rita Bilia; Tolga Eichhorn; Anastasia Karioti; Thomas Efferth
Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin.
Cancer genomics & proteomics 2012;9(3):143-51.
2012: Christoph A Doenitz; Thomas Efferth; Ana Anjos; Tobias Greten; Henry J Greten
Can heat and cold be parameterized? Clinical data of a preliminary study.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2012;10(5):532-7.
2012: Halil Uzuner; Elizabeth M Williamson; Rudolf Bauer; Yung-Chi Cheng; Alberto Dias; Thomas Efferth; Hani El-Nezami; Tai-Ping Fan; De-An Guo; Michael Heinrich; Bruce M Hendry; Peter J Hylands; Nicola Robinson; Qihe Xu
Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities.
Journal of ethnopharmacology 2012;140(3):458-68.
2012: Moustapha Ouedraogo; Olavi Pelkonen; Fan Qu; Debbie Shaw; Caroline Stévigny; Jue Zhou; Thomas Baudoux; Kelvin Chan; Jean-Marie Colet; Thomas Efferth; Joëlle Nortier; Pierre Duez
Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms.
Journal of ethnopharmacology 2012;140(3):492-512.
2012: Thomas Efferth; Henry Johannes Greten
The European directive on traditional herbal medicinal products: friend or foe for plant-based therapies?
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2012;10(4):357-61.
2012: Rashda Abbasi; Thomas Efferth; Xiaojiang Hao; Christine Kuhmann; Till Opatz; Odilia Popanda; Peter Schmezer
The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells.
Toxicology and applied pharmacology 2012;259(3):302-10.
2012: Lily Weiß; Thomas Efferth
Polo-like kinase 1 as target for cancer therapy.
Experimental hematology & oncology 2012;1(1):38.
2012: Benjamin Wiench; Tolga Eichhorn; Malte Paulsen; Thomas Efferth
Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():726025.
2012: Thomas Efferth
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules.
Current medicinal chemistry 2012;19(33):5735-44.
2012: Victor Kuete; Benjamin Wiench; Tolga Eichhorn; B Krusche; Thomas Efferth
Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A.
Cell division 2012;7(1):16.
2012: Victor Kuete; Namrita Lall; Thomas Efferth
Anti-infective and antiproliferative potential of african medicinal plants.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():535219.
2012: Serkan Sertel; Margaret E Tome; Judith Bauer; Margaret M Briehl; Kai Hock; Peter K Plinkert; Thomas Efferth
Factors determining sensitivity and resistance of tumor cells to arsenic trioxide.
PloS one 2012;7(5):e35584.
2012: Wei Wang; Yuangang Zu; Yujie Fu; Thomas Efferth
In vitro antioxidant and antimicrobial activity of extracts from Morus alba L. leaves, stems and fruits.
The American journal of Chinese medicine 2012;40(2):349-56.
2012: Wei Wang; Yuangang Zu; Nan Li; Meng Luo; Thomas Efferth
Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components.
Molecules (Basel, Switzerland) 2012;17(3):2704-13.
2012: Victor Kuete; Tarik A Mohamed; Abdelaaty abdelaziz Shahat; Benjamin Wiench; Aimé G Fankam; Mohamed-Elamir F Hegazy; Thomas Efferth
Antibacterial activity and cytotoxicity of selected Egyptian medicinal plants.
Planta medica 2012;78(2):193-9.
2011: Victor Kuete; Thomas Efferth
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy.
Journal of ethnopharmacology 2011;137(1):752-66.
2011: Thomas Efferth; Florian Herrmann; Ahmed Tahrani; Michael Wink
Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(11):959-69.
2011: Denise Bamberger; Nora Jantzer; Katharina Leidner; Joachim Arend; Thomas Efferth
Fighting mycobacterial infections by antibiotics, phytochemicals and vaccines.
Microbes and infection / Institut Pasteur 2011;13(7):613-23.
2011: Dirk Theile; Vincent Bertholet; Gerhard Dyckhoff; Thomas Efferth; Walter Emil Haefeli; Christel Herold-Mende; Nahal Ketabi-Kiyanvash; Johanna Weiss
Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma.
Head & neck 2011;33(7):959-68.
2011: Dana G Wolf; Avichai Shimoni; Igor B Resnick; Thomas Stamminger; Avidan U Neumann; Sunwen Chou; Thomas Efferth; Orit Caplan; Jessica Rose; Arnon Nagler; Manfred Marschall
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation.
Antiviral research 2011;90(3):183-6.
2011: Shahid Soomro; Almut Brand; Peter Carmeliet; Canan Cetin; Edward M Conway; Mieke Dewerchin; Gert Fricker; Pavlo Holenya; Cindy Horwedel; Herwig Jansen; V Badireenath Konkimalla; Tobias Langenberg; Anne Mahringer; Thomas Efferth
Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties.
Journal of cellular and molecular medicine 2011;15(5):1122-35.
2011: Victor Kuete; B Krusche; Mahmoud Youns; Igor Voukeng; Aimé G Fankam; Simplice Tankeo; Stephen Lacmata; Thomas Efferth
Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts.
Journal of ethnopharmacology 2011;134(3):803-12.
2011: Serkan Sertel; Yujie Fu; Yuangang Zu; Blanka Rebacz; Badireenath Konkimalla; Peter K Plinkert; Alwin Krämer; Jürg Gertsch; Thomas Efferth
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine.
Biochemical pharmacology 2011;81(6):723-35.
2011: Mahmoud Youns; Jörg D Hoheisel; Thomas Efferth
Therapeutic and diagnostic applications of nanoparticles.
Current drug targets 2011;12(3):357-65.
2011: Anne Hamacher-Brady; Henning A Stein; Simon Turschner; Ina Toegel; Rodrigo Mora; Nina Jennewein; Thomas Efferth; Roland Eils; Nathan R Brady
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
The Journal of biological chemistry 2011;286(8):6587-601.
2011: Nan Wu; Yu Kong; Yuangang Zu; Yujie Fu; Zhiguo Liu; Ronghua Meng; Xia Liu; Thomas Efferth
Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(2-3):110-8.
2011: Nan Wu; Yu Kong; Yujie Fu; Yuangang Zu; Zhiwei Yang; Mei Yang; Xiao Peng; Thomas Efferth
In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound derived from pigeon pea [Cajanus cajan (L.) Millsp.] leaves.
Journal of agricultural and food chemistry 2011;59(1):437-43.
2011: Mahmoud Youns; Thomas Efferth; Jörg D Hoheisel
Transcript profiling identifies novel key players mediating the growth inhibitory effect of NS-398 on human pancreatic cancer cells.
European journal of pharmacology 2011;650(1):170-7.
2011: Yuan Gao; Meng Luo; Wei Wang; Jin Tong Zhao; Yuan Gang Zu; Yu-Jie Fu; Thomas Efferth
Characterization of five fungal endophytes producing Cajaninstilbene acid isolated from pigeon pea [Cajanus cajan (L.) Millsp].
PloS one 2011;6(11):e27589.
2011: Victor Kuete; Pierre Tane; Hippolyte K Wabo; Benjamin Wiench; Kenneth O Eyong; Michel T Feussi; Gabriel N Folefoc; B Krusche; Thomas Efferth
Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants.
PloS one 2011;6(8):e21762.
2011: G Polier; N Ribeiro; L Desaubry; J Ding; Thomas Efferth; D Eick; Marco Giaisi; R Köhler; B V Konkimalla; P H Krammer; Min Li-Weber
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.
Cell death & disease 2011;2():e182.
2011: O Wahl; Joachim Arend; E Herres; M Oswald; L Tretzel; Thomas Efferth
Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products.
Current medicinal chemistry 2011;18(21):3136-55.
2011: Thomas Efferth; Peter Langguth
Transport processes of radiopharmaceuticals and -modulators.
Radiation oncology (London, England) 2011;6():59.
2011: Beatrice E Bachmeier; Iduna Fichtner; Peter H Killian; Emanuel Kronski; Ulrich Pfeffer; Thomas Efferth
Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
PloS one 2011;6(5):e20550.
2011: Ping Yu; Yuangang Zu; Yujie Fu; Thomas Efferth
Catalytic synthesis of α-oxoketene S,S-acetals in a wet ionic liquid [Bmim]Cl/H₂O homogeneous system.
Molecules (Basel, Switzerland) 2011;16(6):4500-10.
2011: Serkan Sertel; Tolga Eichhorn; Peter K Plinkert; Thomas Efferth
Chemical Composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells.
Anticancer research 2011;31(1):185-91.
2011: Serkan Sertel; Tolga Eichhorn; Peter K Plinkert; Thomas Efferth
Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma.
Anticancer research 2011;31(1):81-7.
2011: A Müllner; A Helfer; D Kotlyar; J Oswald; Thomas Efferth
Chemistry and pharmacology of neglected helminthic diseases.
Current medicinal chemistry 2011;18(5):767-89.
2011: K Schleich; C Nürnberger; A Sobanski; Thomas Efferth
Vaccination and antiviral treatment of neglected diseases caused by flaviviral infections.
Current medicinal chemistry 2011;18(4):604-14.
2011: Xiao-lei Liu; Xin-jian Zhang; Yu-Jie Fu; Yuangang Zu; Nan Wu; Lu Liang; Thomas Efferth
Cajanol inhibits the growth of Escherichia coli and Staphylococcus aureus by acting on membrane and DNA damage.
Planta medica 2011;77(2):158-63.
2011: Thomas Efferth; Egon Koch
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.
Current drug targets 2011;12(1):122-32.
2010: Mahmoud Youns; Jörg D Hoheisel; Thomas Efferth
Toxicogenomics for the prediction of toxicity related to herbs from traditional Chinese medicine.
Planta medica 2010;76(17):2019-25.
2010: Zhiwei Yang; Nan Wu; Yujie Fu; Gang Yang; Wei Wang; Yuangang Zu; Thomas Efferth
Anti-infectious bronchitis virus (IBV) activity of 1,8-cineole: effect on nucleocapsid (N) protein.
Journal of biomolecular structure & dynamics 2010;28(3):323-30.
2010: Serkan Sertel; Peter K Plinkert; Thomas Efferth
Natural products derived from traditional chinese medicine as novel inhibitors of the epidermal growth factor receptor.
Combinatorial chemistry & high throughput screening 2010;13(10):849-54.
2010: Lisa Steinbrück; Gislene Pereira; Thomas Efferth
Effects of artesunate on cytokinesis and G₂/M cell cycle progression of tumour cells and budding yeast.
Cancer genomics & proteomics 2010;7(6):337-46.
2010: Meng Luo; Xia Liu; Yuangang Zu; Yujie Fu; Su Zhang; Liping Yao; Thomas Efferth
Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway.
Chemico-biological interactions 2010;188(1):151-60.
2010: Ming-Ming Yan; Cai-Yun Chen; Bao-Shan Zhao; Yuan-Gang Zu; Yu-Jie Fu; Wei Liu; Thomas Efferth
Enhanced extraction of astragalosides from Radix Astragali by negative pressure cavitation-accelerated enzyme pretreatment.
Bioresource technology 2010;101(19):7462-71.
2010: Lindsey N Fix; Maitri Shah; Thomas Efferth; Mary A Farwell; Baohong Zhang
MicroRNA expression profile of MCF-7 human breast cancer cells and the effect of green tea polyphenon-60.
Cancer genomics & proteomics 2010;7(5):261-77.
2010: Mahmoud Youns; Yu-Jie Fu; Yuan-Gang Zu; Anne Kramer; V Badireenath Konkimalla; Bernhard Radlwimmer; Holger Sültmann; Thomas Efferth
Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics.
Naunyn-Schmiedeberg's archives of pharmacology 2010;382(3):221-34.
2010: Suhail Ahmed Kabeer Rasheed; Thomas Efferth; Irfan Ahmed Asangani; Heike Allgayer
First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases.
International journal of cancer. Journal international du cancer 2010;127(6):1475-85.
2010: Thomas Efferth
Cancer therapy with natural products and medicinal plants.
Planta medica 2010;76(11):1035-6.
2010: Thomas Efferth
Personalized cancer medicine: from molecular diagnostics to targeted therapy with natural products.
Planta medica 2010;76(11):1143-54.
2010: Lina Pinto-Garcia; Thomas Efferth; Amada Torres; Jörg D Hoheisel; Mahmoud Youns
Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.
Planta medica 2010;76(11):1155-61.
2010: Nisarat Siriwatanametanon; Bernd L Fiebich; Thomas Efferth; Jose M. Prieto; Michael Heinrich
Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities.
Journal of ethnopharmacology 2010;130(2):196-207.
2010: Cindy Horwedel; Svetlana B Tsogoeva; Shengwei Wei; Thomas Efferth
Cytotoxicity of artesunic acid homo- and heterodimer molecules toward sensitive and multidrug-resistant CCRF-CEM leukemia cells.
Journal of medicinal chemistry 2010;53(13):4842-8.
2010: Anne Mahringer; Shirin Karamustafa; Daniel Klotz; Stefan Kahl; Thomas Efferth; Yifen Wang; Junsong Wang; Hai-Yang Liu; Herbert Boechzelt; Xiaojiang Hao; Rudolf Bauer; Gert Fricker; Thomas Efferth
Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine.
Cancer genomics & proteomics 2010;7(4):191-205.
2010: Jose J G Marin; B Castaño; A G Blazquez; R Rosales; Thomas Efferth; Maria J Monte
Strategies for overcoming chemotherapy resistance in enterohepatic tumours.
Current molecular medicine 2010;10(5):467-85.
2010: V Badireenath Konkimalla; Thomas Efferth
Inhibition of epidermal growth factor receptor-overexpressing cancer cells by camptothecin, 20-(N,N-diethyl) glycinate.
Biochemical pharmacology 2010;80(1):39-49.
2010: Xin Hua; Yu-Jie Fu; Yuangang Zu; Nan Wu; Yu Kong; Ji Li; Xiao Peng; Thomas Efferth
Plasma pharmacokinetics and tissue distribution study of cajaninstilbene acid in rats by liquid chromatography with tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2010;52(2):273-9.
2010: V Badireenath Konkimalla; Martina Blunder; Rudolf Bauer; Thomas Efferth
Inhibition of inducible nitric oxide synthase by bis(helenalinyl)glutarate in RAW264.7 macrophages.
Biochemical pharmacology 2010;79(11):1573-80.
2010: Beate Rinner; Nadine Kretschmer; Heike Knausz; Andrea Mayer; Herbert Boechzelt; Xiao-Jiang Hao; Guenther Heubl; Thomas Efferth; Helmut Schaider; Rudolf Bauer
A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner.
Journal of ethnopharmacology 2010;129(2):182-8.
2010: Yuangang Zu; Huimin Yu; Lu Liang; Yujie Fu; Thomas Efferth; Xia Liu; Nan Wu
Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells.
Molecules (Basel, Switzerland) 2010;15(5):3200-10.
2010: F V Donenko; R H Ziganshin; N Yu Anisimova; K E Voyushin; S M Sitdikova; B S Amandzholov; M V Kiselevskii; Thomas Efferth
Identification of serpin (alpha-1-antitrypsin) as serum growth inhibitory factor in murine ehrlich carcinoma by proteomics.
Cancer genomics & proteomics 2010;7(3):147-56.
2010: Thomas Efferth; Bernd Kaina
Toxicity of the antimalarial artemisinin and its dervatives.
Critical reviews in toxicology 2010;40(5):405-21.
2010: Serkan Sertel; Tolga Eichhorn; Sebastian Sieber; Alexandra Sauer; Johanna Weiss; Peter K Plinkert; Thomas Efferth
Factors determining sensitivity or resistance of tumor cell lines towards artesunate.
Chemico-biological interactions 2010;185(1):42-52.
2010: V Badireenath Konkimalla; Thomas Efferth
Inhibition of epidermal growth factor receptor over-expressing cancer cells by the aphorphine-type isoquinoline alkaloid, dicentrine.
Biochemical pharmacology 2010;79(8):1092-9.
2010: Serkan Sertel; Tolga Eichhorn; Christian H Simon; Peter K Plinkert; Steven W Johnson; Thomas Efferth
Pharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell lines.
Molecules (Basel, Switzerland) 2010;15(4):2886-910.
2010: Su Zhang; Yuan-Gang Zu; Yu-Jie Fu; Meng Luo; Wei Liu; Ji Li; Thomas Efferth
Supercritical carbon dioxide extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) and its anti-oxidant activity.
Bioresource technology 2010;101(7):2537-44.
2010: Mahmoud Youns; Jörg D Hoheisel; Thomas Efferth
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
Current drug discovery technologies 2010;7(1):37-45.
2010: Nili Ruimi; Haithem Rwashdeh; Solomon P Wasser; Badireenath Konkimalla; Thomas Efferth; Monica Borgatti; Roberto Gambari; Jamal Mahajna
Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells.
International journal of molecular medicine 2010;25(3):421-32.
2010: Su Zhang; Yuan-Gang Zu; Yu-Jie Fu; Meng Luo; Dong-Yang Zhang; Thomas Efferth
Rapid microwave-assisted transesterification of yellow horn oil to biodiesel using a heteropolyacid solid catalyst.
Bioresource technology 2010;101(3):931-6.
2010: Victor Kuete; Thomas Efferth
Cameroonian medicinal plants: pharmacology and derived natural products.
Frontiers in pharmacology 2010;1():123.
2010: Yue Chen; Yuangang Zu; Yujie Fu; Xuan Zhang; Ping Yu; Guoyong Sun; Thomas Efferth
Efficient Lewis acid ionic liquid-catalyzed synthesis of the key intermediate of coenzyme Q10 under microwave irradiation.
Molecules (Basel, Switzerland) 2010;15(12):9486-95.
2010: K Nussbaum; J Honek; C M C v C Cadmus; Thomas Efferth
Trypanosomatid parasites causing neglected diseases.
Current medicinal chemistry 2010;17(15):1594-617.
2010: M Bechtle; S Chen; Thomas Efferth
Neglected diseases caused by bacterial infections.
Current medicinal chemistry 2010;17(1):42-60.
2009: Shuangming Li; Yujie Fu; Yuangang Zu; Baishi Zu; Ying Wang; Thomas Efferth
Determination of paclitaxel and its analogues in the needles of Taxus species by using negative pressure cavitation extraction followed by HPLC-MS-MS.
Journal of separation science 2009;32(22):3958-66.
2009: Marcel Ramacher; Viktor Umansky; Thomas Efferth
Effect of artesunate on immune cells in ret-transgenic mouse melanoma model.
Anti-cancer drugs 2009;20(10):910-7.
2009: Thomas E Kraft; Daniel Parisotto; Christina Schempp; Thomas Efferth
Fighting cancer with red wine? Molecular mechanisms of resveratrol.
Critical reviews in food science and nutrition 2009;49(9):782-99.
2009: Thomas Efferth
Natural products pave their way in cancer therapy.
Cancer biology & therapy 2009;8(19):1869-70.
2009: Mohamed Lotfy Ashour; Mahmoud El-Readi; Mahmoud Youns; Sri Mulyaningsih; Frank Sporer; Thomas Efferth; Michael Wink
Chemical composition and biological activity of the essential oil obtained from Bupleurum marginatum (Apiaceae).
The Journal of pharmacy and pharmacology 2009;61(8):1079-87.
2009: Mahmoud Youns; Thomas Efferth; Jürgen Reichling; Kurt Fellenberg; Andrea Bauer; Jörg D Hoheisel
Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells.
Biochemical pharmacology 2009;78(3):273-83.
2009: Yuangang Zu; Xia Liu; Yujie Fu; Xiaoguang Shi; Nan Wu; Liping Yao; Thomas Efferth
Cytotoxic activity of isoliquiritigenin towards CCRF-CEM leukemia cells and its effect on DNA damage.
Planta medica 2009;75(10):1134-40.
2009: Sebastian Sieber; Georg Gdynia; Wilfried Roth; Benjamin Bonavida; Thomas Efferth
Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate.
International journal of oncology 2009;35(1):149-58.
2009: FV Donenko; R K Ziganshin; SM Sitdikova; BS Amandzholov; MV Kiselevskii; Thomas Efferth
Induction of resistance to murine tumor development is associated with alterations in the glycosylation of blood serum proteins.
Molecular medicine reports 2009;2(3):487-95.
2009: Wei Liu; Yujie Fu; Yuangang Zu; Yu Kong; Lin Zhang; Baishi Zu; Thomas Efferth
Negative-pressure cavitation extraction for the determination of flavonoids in pigeon pea leaves by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A 2009;1216(18):3841-50.
2009: Mathias Felix Leber; Thomas Efferth
Molecular principles of cancer invasion and metastasis (review).
International journal of oncology 2009;34(4):881-95.
2009: V Badireenath Konkimalla; James A McCubrey; Thomas Efferth
The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.
Current cancer drug targets 2009;9(1):72-80.
2009: Simon Turschner; Thomas Efferth
Drug resistance in Plasmodium: natural products in the fight against malaria.
Mini reviews in medicinal chemistry 2009;9(2):206-2124.
2009: Yuangang Zu; Mingming Yan; Yujie Fu; Wei Liu; Lin Zhang; Chengbo Gu; Thomas Efferth
Determination and quantification of astragalosides in Radix Astragali and its medicinal products using LC-MS.
Journal of separation science 2009;32(4):517-25.
2009: Shuangming Li; Yujie Fu; Yuangang Zu; Rui Sun; Ying Wang; Lin Zhang; Hao Luo; Chengbo Gu; Thomas Efferth
Determination of paclitaxel and other six taxoids in Taxus species by high-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2009;49(1):81-9.
2009: Yu Kong; Wei Ma; Xia Liu; Yuangang Zu; Yujie Fu; Nan Wu; Lu Liang; Liping Yao; Thomas Efferth
Cytotoxic activity of curcumin towards CCRF-CEM leukemia cells and its effect on DNA damage.
Molecules (Basel, Switzerland) 2009;14(12):5328-38.
2009: Y Fu; S Li; Yuangang Zu; G Yang; Z Yang; M Luo; S Jiang; Michael Wink; Thomas Efferth
Medicinal chemistry of paclitaxel and its analogues.
Current medicinal chemistry 2009;16(30):3966-85.
2009: Julia Hupfeld; Thomas Efferth
Review. Drug resistance of human immunodeficiency virus and overcoming it by natural products.
In vivo (Athens, Greece) 2009;23(1):1-6.
2009: Wei Wang; Yu-Jie Fu; Yuangang Zu; N Wu; J Reichling; Thomas Efferth
Lipid rafts play an important role in the vesicular stomatitis virus life cycle.
Archives of virology 2009;154(4):595-600.
2009: Yujie Fu; Liyan Chen; Yuangang Zu; Zhiguo Liu; Xia Liu; Ying Liu; Liping Yao; Thomas Efferth
The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action.
Archives of dermatology 2009;145(1):86-8.
2009: Carolin Wohlfarth; Thomas Efferth
Natural products as promising drug candidates for the treatment of hepatitis B and C.
Acta pharmacologica Sinica 2009;30(1):25-30.
2008: Silviya Stoeva; Thomas Efferth
Human cytomegalovirus: Drug resistance and new treatment options using natural products.
Molecular medicine reports 2008;1(6):781-5.
2008: Stefanie Gehrig; Thomas Efferth
Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (Review).
International journal of molecular medicine 2008;22(4):411-9.
2008: Thomas Efferth; Marta R Romero; Dana G Wolf; Thomas Stamminger; Jose J G Marin; Manfred Marschall
The antiviral activities of artemisinin and artesunate.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(6):804-11.
2008: Tabea Anne Mundinger; Thomas Efferth
Herpes simplex virus: Drug resistance and new treatment options using natural products (Review).
Molecular medicine reports 2008;1(5):611-6.
2008: Tilman Polonio; Thomas Efferth
Leishmaniasis: drug resistance and natural products (review).
International journal of molecular medicine 2008;22(3):277-86.
2008: Badireenath Konkimalla; Martina Blunder; Bernhard Korn; Shahid Soomro; Herwig Jansen; Wonsuk Chang; Gary H Posner; Rudolf Bauer; Thomas Efferth
Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(2):184-91.
2008: Shougang Jiang; Yuangang Zu; Yuejie Fu; Yu Zhang; Thomas Efferth
Activation of the mitochondria-driven pathway of apoptosis in human PC-3 prostate cancer cells by a novel hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel.
International journal of oncology 2008;33(1):103-11.
2008: Paul C H Li; Elena Lam; Wynand Roos; Malgorzata Z Zdzienicka; Bernd Kaina; Thomas Efferth
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.
Cancer research 2008;68(11):4347-51.
2008: Badireenath Konkimalla; Bernd Kaina; Thomas Efferth
Role of transporter genes in cisplatin resistance.
In vivo (Athens, Greece) 2008;22(3):279-83.
2008: Michael Y Shapira; Igor B Resnick; Sunwen Chou; Avidan U Neumann; Nell S Lurain; Thomas Stamminger; Orit Caplan; Niveen Saleh; Thomas Efferth; Manfred Marschall; Dana G Wolf
Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1455-7.
2008: Thomas Efferth; Badireenath Konkimalla; Yi-Fen Wang; Axel Sauerbrey; Silke Meinhardt; Felix Zintl; Jürgen Mattern; Manfred Volm
Prediction of broad spectrum resistance of tumors towards anticancer drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2405-12.
2008: Badireenath Konkimalla; Thomas Efferth
Evidence-based Chinese medicine for cancer therapy.
Journal of ethnopharmacology 2008;116(2):207-10.
2008: Badireenath Konkimalla; Gan Wang; Bernd Kaina; Thomas Efferth
Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine.
Cancer genomics & proteomics 2008;5(2):79-84.
2008: Yujie Fu; Yuangang Zu; Wei Liu; Lin Zhang; Meihong Tong; Thomas Efferth; Yu Kong; Chunlian Hou; Liyan Chen
Determination of vitexin and isovitexin in pigeonpea using ultrasonic extraction followed by LC-MS.
Journal of separation science 2008;31(2):268-75.
2008: Yujie Fu; Yuangang Zu; Shuangming Li; Rui Sun; Thomas Efferth; Wei Liu; Shougang Jiang; Hao Luo; Ying Wang
Separation of 7-xylosyl-10-deacetyl paclitaxel and 10-deacetylbaccatin III from the remainder extracts free of paclitaxel using macroporous resins.
Journal of chromatography. A 2008;1177(1):77-86.
2008: Badireenath Konkimalla; Thomas Efferth
Anti-cancer natural product library from traditional chinese medicine.
Combinatorial chemistry & high throughput screening 2008;11(1):7-15.
2008: Thomas Efferth; Stefan Kahl; Kerstin Paulus; Michael Adams; Rolf Rauh; Herbert Boechzelt; Xiaojiang Hao; Bernd Kaina; Rudolf Bauer
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
Molecular cancer therapeutics 2008;7(1):152-61.
2007: Michael Adams; Anne Mahringer; Olaf Kunert; Gert Fricker; Thomas Efferth; Rudolf Bauer
Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.
Planta medica 2007;73(15):1554-7.
2007: Michael Adams; Anne Mahringer; Rudolf Bauer; Gert Fricker; Thomas Efferth
In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii.
Planta medica 2007;73(14):1475-8.
2007: Yujie Fu; Yuangang Zu; Liyan Chen; Thomas Efferth; Huili Liang; Zhiguo Liu; Wei Liu
Investigation of antibacterial activity of rosemary essential oil against Propionibacterium acnes with atomic force microscopy.
Planta medica 2007;73(12):1275-80.
2007: Yujie Fu; Yuangang Zu; Liyan Chen; Xiaoguang Shi; Zhe Wang; Su Sun; Thomas Efferth
Antimicrobial activity of clove and rosemary essential oils alone and in combination.
Phytotherapy research : PTR 2007;21(10):989-94.
2007: Thomas Efferth; Paul C H Li; Badireenath Konkimalla; Bernd Kaina
From traditional Chinese medicine to rational cancer therapy.
Trends in molecular medicine 2007;13(8):353-61.
2007: Jean-Pierre Gillet; Thomas Efferth; José Remacle
Chemotherapy-induced resistance by ATP-binding cassette transporter genes.
Biochimica et biophysica acta 2007;1775(2):237-62.
2007: Marta R Romero; Maria A Serrano; Thomas Efferth; Marcelino Alvarez; Jose J G Marin
Effect of cantharidin, cephalotaxine and homoharringtonine on "in vitro" models of hepatitis B virus (HBV) and bovine viral diarrhoea virus (BVDV) replication.
Planta medica 2007;73(6):552-8.
2007: Thomas Efferth
Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedside.
Planta medica 2007;73(4):299-309.
2007: Thomas Efferth; Hayato Miyachi; Helmut Bartsch
Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy.
Cancer genomics & proteomics 2007;4(2):81-91.
2007: Badireenath Konkimalla; Venkatramana Laxminarayana Suhas; Nagasuma R Chandra; Erich Gebhart; Thomas Efferth
Diagnosis and therapy of oral squamous cell carcinoma.
Expert review of anticancer therapy 2007;7(3):317-29.
2007: Johanna Weiss; Johanna Rose; Caroline Henrike Storch; Nahal Ketabi-Kiyanvash; Alexandra Sauer; Walter E Haefeli; Thomas Efferth
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs.
The Journal of antimicrobial chemotherapy 2007;59(2):238-45.
2007: Gerhard Kelter; Daniel Steinbach; Badireenath Konkimalla; Tsuyoshi Tahara; Shigeru Taketani; Heinz-Herbert Fiebig; Thomas Efferth
Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate.
PloS one 2007;2(8):e798.
2007: Thomas Efferth; Yu-Jie Fu; Yuangang Zu; Günter Schwarz; Badireenath Konkimalla; Michael Wink
Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine.
Current medicinal chemistry 2007;14(19):2024-32.
2007: Thomas Efferth; Marco Giaisi; Anette Merling; Peter H Krammer; Min Li-Weber
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.
PloS one 2007;2(8):e693.
2007: Farooq Kiani; Sonja M Schwarzl; Stefan Fischer; Thomas Efferth
Three-dimensional modeling of glucose-6-phosphate dehydrogenase-deficient variants from German ancestry.
PloS one 2007;2(7):e625.
2007: Rolf Rauh; Stefan Kahl; Herbert Boechzelt; Rudolf Bauer; Bernd Kaina; Thomas Efferth
Molecular biology of cantharidin in cancer cells.
Chinese medicine 2007;2():8.
2006: Yujie Fu; Yuangang Zu; Wei Liu; Thomas Efferth; Naijing Zhang; Xiaona Liu; Yu Kong
Optimization of luteolin separation from pigeonpea [Cajanus cajan (L.) Millsp.] leaves by macroporous resins.
Journal of chromatography. A 2006;1137(2):145-52.
2006: Surajit Majumder; Pranabananda Dutta; Pratima Mukherjee; E R Datta; Thomas Efferth; S Bhattacharya; Soumitra K Choudhuri
Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid.
Cancer letters 2006;244(1):16-23.
2006: Marta R Romero; Maria A Serrano; Marta Vallejo; Thomas Efferth; Marcelino Alvarez; Jose J G Marin
Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV).
Planta medica 2006;72(13):1169-74.
2006: Yi-Fen Wang; Guo-Fang Lai; Thomas Efferth; Jian-Xin Cao; Shi-De Luo
New glycosides from Tetracentron sinense and their cytotoxic activity.
Chemistry & biodiversity 2006;3(9):1023-30.
2006: Thomas Efferth; Jean-Pierre Gillet; Axel Sauerbrey; Felix Zintl; Vincent Bertholet; Françoise de Longueville; José Remacle; Daniel Steinbach
Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia.
Molecular cancer therapeutics 2006;5(8):1986-94.
2006: Daniel Steinbach; Jean-Pierre Gillet; Axel Sauerbrey; Bernd Gruhn; Kristin Dawczynski; Vincent Bertholet; Françoise de Longueville; Felix Zintl; José Remacle; Thomas Efferth
ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4357-63.
2006: Ananda Mookerjee; Jayati Mookerjee Basu; Pranabananda Dutta; Surajit Majumder; Sankar Bhattacharyya; Jaydip Biswas; Smarajit Pal; Pratima Mukherjee; Sanghamitra Raha; Rathindranath Baral; Tania Das; Thomas Efferth; Gourisankar Sa; Shyamal Roy; Soumitra K Choudhuri
Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4339-49.
2006: Michael Adams; Thomas Efferth; Rudolf Bauer
Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.
Planta medica 2006;72(9):862-4.
2006: Luca Anfosso; Thomas Efferth; Adriana Albini; Ulrich Pfeffer
Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins.
The pharmacogenomics journal 2006;6(4):269-78.
2006: Yi-Fen Wang; Jian-Xin Cao; Thomas Efferth; Guo-Fang Lai; Shi-De Luo
Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn.
Chemistry & biodiversity 2006;3(6):646-53.
2006: Thomas Efferth
Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells.
Current drug targets 2006;7(4):407-21.
2006: Thomas Efferth
Pharmacognosy and molecular pharmacology of small molecules of natural origin for cancer therapy and chemoprevention.
Current drug targets 2006;7(3):237-8.
2006: Thomas Efferth; Sonja M Schwarzl; J Smith; R Osieka
Role of glucose-6-phosphate dehydrogenase for oxidative stress and apoptosis.
Cell death and differentiation 2006;13(3):527-8; author reply 529-30.
2006: Suzanne J F Kaptein; Thomas Efferth; Martina Leis; Sabine Rechter; Sabrina Auerochs; Martina Kalmer; Cathrien A Bruggeman; Cornelis Vink; Thomas Stamminger; Manfred Marschall
The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo.
Antiviral research 2006;69(2):60-9.
2006: Ananda Mookerjee; Jayati Mookerjee Basu; Surajit Majumder; Shilpak Chatterjee; Gouri Sankar Panda; Pranabananda Dutta; Smarajit Pal; Pratima Mukherjee; Thomas Efferth; Syamal Roy; Soumitra K Choudhuri
A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo.
BMC cancer 2006;6():267.
2005: Thomas G Berger; Detlef Dieckmann; Thomas Efferth; Erwin S Schultz; Jens Oliver Funk; Andreas Baur; Gerold Schuler
Artesunate in the treatment of metastatic uveal melanoma--first experiences.
Oncology reports 2005;14(6):1599-603.
2005: Marta R Romero; Thomas Efferth; Maria A Serrano; Beatriz Castaño; Rocio I R Macias; Oscar Briz; Jose J G Marin
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.
Antiviral research 2005;68(2):75-83.
2005: Sonja M Schwarzl; Jeremy Smith; Bernd Kaina; Thomas Efferth
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms.
International journal of molecular medicine 2005;16(4):553-7.
2005: Thomas Efferth; Manfred Volm
Pharmacogenetics for individualized cancer chemotherapy.
Pharmacology & therapeutics 2005;107(2):155-76.
2005: Junsong Wang; Yongtang Zheng; Thomas Efferth; Ruirui Wang; Yuemao Shen; Xiaojiang Hao
Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.
Phytochemistry 2005;66(6):697-701.
2005: Thomas Efferth; Rolf Rauh; Stefan Kahl; Maja T Tomicic; Herbert Böchzelt; Margaret E Tome; Margaret M Briehl; Rudolf Bauer; Bernd Kaina
Molecular modes of action of cantharidin in tumor cells.
Biochemical pharmacology 2005;69(5):811-8.
2005: Thomas Efferth
Microarray-based prediction of cytotoxicity of tumor cells to cantharidin.
Oncology reports 2005;13(3):459-63.
2005: Thomas Efferth
Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(1-2):85-97.
2005: Naif S Karadsheh; Terri Gelbart; Hans-Jurgen Schulten; Thomas Efferth; Abdalla Awidi
Relationship between molecular variants and clinical manifestions in twelve glucose-6-phosphate dehydrogenase-deficient patients in Jordan.
Acta haematologica 2005;114(2):125-6.
2005: U Wick; M Kirsch; A Rauch; I Chudoba; berthold lausen; Thomas Efferth; Erich Gebhart
FISH studies on the telomeric regions of the T-cell acute lymphoblastic leukemia cell line CCRF-CEM.
Cytogenetic and genome research 2005;111(1):34-40.
2005: Thomas Efferth; Manfred Volm
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.
In vivo (Athens, Greece) 2005;19(1):225-32.
2005: Sascha Raschke; Vera Balz; Thomas Efferth; Wolfgang A Schulz; Andrea R Florl
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Genes, chromosomes & cancer 2005;42(1):58-67.
2004: Jean-Pierre Gillet; Thomas Efferth; Daniel Steinbach; Jacques Hamels; Françoise de Longueville; Vincent Bertholet; José Remacle
Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes.
Cancer research 2004;64(24):8987-93.
2004: Raffaella Dell'Eva; Ulrich Pfeffer; Roberta Vené; Luca Anfosso; Alessandra Forlani; Adriana Albini; Thomas Efferth
Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate.
Biochemical pharmacology 2004;68(12):2359-66.
2004: Thomas Efferth; Esther B Bachli; Sonja M Schwarzl; Jeroen S Goede; Carol West; Jeremy Smith; Ernest Beutler
Glucose-6-phosphate dehydrogenase (G6PD) deficiency-type Zurich: a splice site mutation as an uncommon mechanism producing enzyme deficiency.
Blood 2004;104(8):2608.
2004: Thomas Efferth; Achille Benakis; Marta R Romero; Maja T Tomicic; Rolf Rauh; Daniel Steinbach; Ralf Häfer; Thomas Stamminger; Franz Oesch; Bernd Kaina; Manfred Marschall
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.
Free radical biology & medicine 2004;37(7):998-1009.
2004: Erich Gebhart; Jutta Ries; Jörg Wiltfang; Thomas Liehr; Thomas Efferth
Genomic gain of the epidermal growth factor receptor harboring band 7p12 is part of a complex pattern of genomic imbalances in oral squamous cell carcinomas.
Archives of medical research 2004;35(5):385-94.
2004: Thomas Efferth; Franz Oesch
Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines.
Biochemical pharmacology 2004;68(1):3-10.
2004: Thomas Efferth; Tzutzuy Ramirez; Erich Gebhart; Marc-Eric Halatsch
Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774.
Biochemical pharmacology 2004;67(9):1689-700.
2004: Beate Rinner; Veronika Siegl; Peter Pürstner; Thomas Efferth; Brigitte Brem; Harald Greger; Roswitha Pfragner
Activity of novel plant extracts against medullary thyroid carcinoma cells.
Anticancer research 2004;24(2A):495-500.
2004: Marc-Eric Halatsch; Esther E Gehrke; Vassilios I Vougioukas; Ingolf C Bötefür; Farhad A-Borhani; Thomas Efferth; Erich Gebhart; Sebastian Domhof; Ursula Schmidt; Michael Buchfelder
Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines.
Journal of neurosurgery 2004;100(3):523-33.
2003: Thomas Efferth; Margaret M Briehl; Margaret E Tome
Role of antioxidant genes for the activity of artesunate against tumor cells.
International journal of oncology 2003;23(4):1231-5.
2003: Thomas Efferth; Erich Gebhart; Douglas Ross; Axel Sauerbrey
Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Biochemical pharmacology 2003;66(4):613-21.
2003: Thomas Efferth; Axel Sauerbrey; Armin Olbrich; Erich Gebhart; Pia Rauch; H Oliver Weber; Jan G Hengstler; Marc-Eric Halatsch; Manfred Volm; Kenneth D Tew; Douglas Ross; Jens Oliver Funk
Molecular modes of action of artesunate in tumor cell lines.
Molecular pharmacology 2003;64(2):382-94.
2003: Thomas Efferth; Axel Sauerbrey; Daniel Steinbach; Erich Gebhart; Hans-Günther Drexler; Hayato Miyachi; Christopher R Chitambar; Cord-Michael Becker; Felix Zintl; Andreas Humeny
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):509-17.
2003: Tzutzuy Ramirez; Karen Thoma; Lucia Taja-Chayeb; Thomas Efferth; lucy Tapia; Marc-Eric Halatsch; Erich Gebhart
Specific patterns of DNA copy number gains and losses in eight new glioblastoma multiforme cell lines.
International journal of oncology 2003;23(2):453-60.
2003: Andreas Humeny; Franz Rödel; Claus Rödel; Rolf Sauer; L Füzesi; Cord-Michael Becker; Thomas Efferth
MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas detected by MALDI-TOF mass spectrometry.
Anticancer research 2003;23(3B):2735-40.
2003: Marc-Eric Halatsch; Esther Gehrke; Farhad A Borhani; Thomas Efferth; Carola Werner; Panos Nomikos; Ursula Schmidt; Michael Buchfelder
EGFR but not PDGFR-beta expression correlates to the antiproliferative effect of growth factor withdrawal in glioblastoma multiforme cell lines.
Anticancer research 2003;23(3B):2315-20.
2003: Thomas Efferth; Axel Sauerbrey; Marc-Eric Halatsch; Douglas Ross; Erich Gebhart
Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(1):56-67.
2003: Thomas Efferth
Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases.
Ageing research reviews 2003;2(1):11-24.
2002: Oliver Galm; Ursula Fabry; Thomas Efferth; Rainhardt Osieka
Synergism between rViscumin and cisplatin is not dependent on ERCC-1 expression.
Cancer letters 2002;187(1-2):143-51.
2002: Thomas Efferth; Armin Olbrich; Axel Sauerbrey; Douglas Ross; Erich Gebhart; Michael Neugebauer
Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sensitive and multidrug-resistant tumor cells.
Anticancer research 2002;22(6C):4221-4.
2002: Erich Gebhart; Karen Thoma; Irmgard Verdorfer; Hans Gunther Drexler; Thomas Efferth
Genomic imbalances in T-cell acute lymphoblastic leukemia cell lines.
International journal of oncology 2002;21(4):887-94.
2002: Manfred Volm; Axel Sauerbrey; F Zintl; Reet Koomägi; Thomas Efferth
Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses.
Oncology reports 2002;9(5):965-9.
2002: Thomas Efferth; Armin Olbrich; Rudolf Bauer
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether.
Biochemical pharmacology 2002;64(4):617-23.
2002: Thomas Efferth; Irmgard Verdorfer; Hayato Miyachi; Axel Sauerbrey; Hans G Drexler; Christopher R Chitambar; Michelle Haber; Erich Gebhart
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood cells, molecules & diseases 2002;29(1):1-13.
2002: Manfred Volm; Reet Koomägi; Thomas Efferth; Jürgen Mattern
Protein expression profiles of non-small cell lung carcinomas: correlation with histological subtype.
Anticancer research 2002;22(4):2321-4.
2002: Pearlly S Yan; Thomas Efferth; Hsiao-Ling Chen; Jeffrey Lin; Franz Rödel; Laszlo Fuzesi; Hui-Ming (Tim) Huang
Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation.
Methods (San Diego, Calif.) 2002;27(2):162-9.
2002: Manfred Volm; Reet Koomägi; Jürgen Mattern; Thomas Efferth
Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(6):1843-8.
2002: Thomas Efferth; Manfred Marschall; Xin Wang; Shu-Mei Huong; Ilona Hauber; Armin Olbrich; Martina Kronschnabl; Thomas Stamminger; Eng-Shang Huang
Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses.
Journal of molecular medicine (Berlin, Germany) 2002;80(4):233-42.
2002: Thomas Efferth; Mary Davey; Armin Olbrich; Gerhard Rücker; Erich Gebhart; Ross Davey
Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells.
Blood cells, molecules & diseases 2002;28(2):160-8.
2002: Thomas Efferth; Reet Koomägi; Jürgen Mattern; Manfred Volm
Expression profile of proteins involved in the xenotransplantability of non-small cell lung cancers into athymic nude mice.
International journal of oncology 2002;20(2):391-5.
2002: Anja Weise; Thomas Liehr; Thomas Efferth; Alma Kuechler; Erich Gebhart
Comparative M-FISH and CGH analyses in sensitive and drug-resistant human T-cell acute leukemia cell lines.
Cytogenetic and genome research 2002;98(2-3):118-25.
2002: Manfred Volm; Reet Koomägi; Jürgen Mattern; Thomas Efferth
Protein expression profile of primary human squamous cell lung carcinomas indicative of the incidence of metastases.
Clinical & experimental metastasis 2002;19(5):385-90.
2002: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
Interleukin-6 affects melphalan-induced DNA damage and repair in human multiple myeloma cells.
Anticancer research 2002;22(1A):231-4.
2002: Thomas Efferth; Hayato Miyachi; Hans Günther Drexler; Erich Gebhart
Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells.
Blood cells, molecules & diseases 2002;28(1):47-56.
2001: Thomas Efferth; Paul Thelen; HG Schulten; ME Bode; Bernd Granzen; AJ Beniers; Rolf Mertens; Rolf-Hermann Ringert; Olaf Gefeller; G Jakse; Laszlo Fuzesi
Differential expression of the multidrug resistance-related protein MRP1 in the histological compartments of nephroblastomas.
International journal of oncology 2001;19(2):367-71.
2001: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
Induction of apoptosis, depletion of glutathione, and DNA damage by extracorporeal photochemotherapy and psoralen with exposure to UV light in vitro.
Anticancer research 2001;21(4A):2777-83.
2001: Thomas Efferth; HG Schulten; Paul Thelen; ME Bode; AJ Beniers; Bernd Granzen; Rolf-Hermann Ringert; Rolf Mertens; Olaf Gefeller; G Jakse; Laszlo Fuzesi
Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas.
Anticancer research 2001;21(4B):2915-20.
2001: Thomas Efferth; ME Bode; HG Schulten; Paul Thelen; Bernd Granzen; AJ Beniers; Rolf Mertens; Olaf Gefeller; Rolf-Hermann Ringert; G Jakse; Laszlo Fuzesi
Differential expression of the lung resistance-related protein/major vault protein in the histological compartments of nephroblastomas.
International journal of oncology 2001;19(1):163-8.
2001: Thomas Efferth; Bernard W Futscher; Rainhardt Osieka
5-Azacytidine modulates the response of sensitive and multidrug-resistant K562 leukemic cells to cytostatic drugs.
Blood cells, molecules & diseases 2001;27(3):637-48.
2001: Thomas Efferth; H Dunstan; Axel Sauerbrey; H Miyachi; Christopher R Chitambar
The anti-malarial artesunate is also active against cancer.
International journal of oncology 2001;18(4):767-73.
2001: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
DNA damage and apoptosis in mononuclear cells from glucose-6-phosphate dehydrogenase-deficient patients (G6PD Aachen variant) after UV irradiation.
Journal of leukocyte biology 2001;69(3):340-2.
2001: Bernd Granzen; Thomas Efferth; U Keller; AJ Beniers; Rolf Mertens; G Jakse; László Füzesi
Differential expression of the drug resistance markers DNA topoisomerase II alpha and glutathione S-transferase-pi in the histological compartments of Wilms' tumors.
Anticancer research 2001;21(1B):771-6.
2001: AJ Beniers; Thomas Efferth; László Füzesi; Bernd Granzen; Rolf Mertens; G Jakse
p53 expression in Wilms' tumor: a possible role as prognostic factor.
International journal of oncology 2001;18(1):133-9.
2000: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
Damage of the kinesin heavy chain gene contributes to the antagonism of cisplatin and paclitaxel.
Anticancer research 2000;20(5A):3211-9.
2000: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
Leptin contributes to the protection of human leukemic cells from cisplatinum cytoxicity.
Anticancer research 2000;20(4):2541-6.
2000: Thomas Efferth; Rainhardt Osieka; E Beutler
Molecular characterization of a German variant of glucose-6-phosphate dehydrogenase deficiency (G6PD Aachen).
Blood cells, molecules & diseases 2000;26(1):101-4.
1999: Thomas Efferth
Testing for tumor drug resistance in the age of molecular medicine. A contribution to the Debate Round-Table on Phenotypic and Genotypic Analyses of Multidrug Resistance (MDR) in Clinical Hospital Practice.
Leukemia 1999;13(10):1627-9.
1999: Thomas Efferth
Biotechnology has come of age.
Journal of molecular medicine (Berlin, Germany) 1999;77(9):634-9.
1997: Thomas Efferth; Ursula Fabry; Rainhardt Osieka
Apoptosis and resistance to daunorubicin in human leukemic cells.
Leukemia 1997;11(7):1180-6.