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Josephine Egan

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Chemicals & Drugs

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Yu-Kyong Shin; Stuart Maudsley; Huan Cai; Wei-na Cong; Josephine M Egan; Wook Kim; Bronwen Martin
Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity.
Wook Kim; Rohit N Kulkarni; Qizong Lao; Eun Kyung Lee; Yu-Kyong Shin; Olga Carlson; Myriam Gorospe; Josephine M Egan
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.
Hongyu Chen; Josephine M Egan; Jennifer L Fiori; Bronwen Martin; Huan Cai; Sana Siddiqui; Stuart Maudsley
Pancreas++: automated quantification of pancreatic islet cells in microscopy images.

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2012: Yu-Kyong Shin; Stuart Maudsley; Huan Cai; Wei-na Cong; Josephine M Egan; Wook Kim; Bronwen Martin
Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity.
The journals of gerontology. Series A, Biological sciences and medical sciences 2012;67(4):336-44.
2012: Wook Kim; Rohit N Kulkarni; Qizong Lao; Eun Kyung Lee; Yu-Kyong Shin; Olga Carlson; Myriam Gorospe; Josephine M Egan
Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.
Science signaling 2012;5(216):ra23.
2012: Hongyu Chen; Josephine M Egan; Jennifer L Fiori; Bronwen Martin; Huan Cai; Sana Siddiqui; Stuart Maudsley
Pancreas++: automated quantification of pancreatic islet cells in microscopy images.
Frontiers in physiology 2012;3():482.
2011: Stuart Maudsley; Bronwen Martin; Josephine M Egan
To be or not to be--obese.
Endocrinology 2011;152(10):3592-6.
2011: Kristofer S Gravenstein; Joshua K Napora; Ryan G Short; Ramona Ramachandran; Olga Carlson; E Jeffrey Metter; Luigi Ferrucci; Josephine M Egan; Chee Wei Chia
Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism.
The Journal of clinical endocrinology and metabolism 2011;96(6):E884-90.
2011: Wook Kim; Maire Eileen Doyle; Zhuo Liu; Qizong Lao; Yu-Kyong Shin; Olga Carlson; Hee Seung Kim; Sam Thomas; Joshua K Napora; Eun Kyung Lee; Ruin Moaddel; Yan Wang; Stuart Maudsley; Bronwen Martin; Rohit N Kulkarni; Josephine M Egan
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells.
Diabetes 2011;60(4):1198-209.
2011: Zhuo Liu; Wook Kim; Zhike Chen; Yu-Kyong Shin; Olga Carlson; Jennifer L Fiori; Li Xin; Joshua K Napora; Ryan Short; Juliana O Odetunde; Qizong Lao; Josephine M Egan
Insulin and glucagon regulate pancreatic α-cell proliferation.
PloS one 2011;6(1):e16096.
2011: Joshua K Napora; Ryan G Short; Denis C Muller; Olga Carlson; Juliana O Odetunde; Xiaoqiang Xu; Michael A Carducci; Thomas G Travison; Marcello Maggio; Josephine M Egan; Shehzad Basaria
High-dose isoflavones do not improve metabolic and inflammatory parameters in androgen-deprived men with prostate cancer.
Journal of andrology 2011;32(1):40-8.
2010: Amanda E T Elson; Cedrick D Dotson; Josephine M Egan; Steven Munger
Glucagon signaling modulates sweet taste responsiveness.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3960-9.
2010: Byung-Joon Kim; Jie Zhou; Bronwen Martin; Olga Carlson; Stuart Maudsley; Nigel H Greig; Mark P Mattson; Ellen E Ladenheim; Jay Wustner; Andrew Turner; Homayoun Sadeghi; Josephine M Egan
Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides.
The Journal of pharmacology and experimental therapeutics 2010;334(3):682-92.
2010: Sari Stenholm; Annemarie Koster; Dawn E Alley; Marjolein Visser; Marcello Maggio; Tamara B Harris; Josephine M Egan; Stefania Bandinelli; Jack M Guralnik; Luigi Ferrucci
Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study.
Clinical endocrinology 2010;73(1):55-65.
2010: B Gwen Windham; Michael Griswold; S Morteza Farasat; Shari Miura Ling; Olga Carlson; Josephine M Egan; Luigi Ferrucci; Samer S Najjar
Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness.
American journal of hypertension 2010;23(5):501-7.
2010: Bronwen Martin; Yu-Kyong Shin; Caitlin M White; Sunggoan Ji; Wook Kim; Olga Carlson; Joshua K Napora; Wayne Chadwick; Megan Chapter; James A Waschek; Mark P Mattson; Stuart Maudsley; Josephine M Egan
Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression.
Diabetes 2010;59(5):1143-52.
2010: S Morteza Farasat; Carolina Valdes; Veena Shetty; Denis C Muller; Josephine M Egan; E Jeffrey Metter; Luigi Ferrucci; Samer S Najjar
Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?
Hypertension 2010;55(2):415-21.
2010: Yu-Kyong Shin; Bronwen Martin; Wook Kim; Caitlin M White; Sunggoan Ji; Yuxiang Sun; Roy G Smith; Jean Sévigny; Matthias H Tschöp; Stuart Maudsley; Josephine M Egan
Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants.
PloS one 2010;5(9):e12729.
2010: Erin Golden; Ana Emiliano; Stuart Maudsley; B Gwen Windham; Olga Carlson; Josephine M Egan; Ira Driscoll; Luigi Ferrucci; Bronwen Martin; Mark P Mattson
Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging.
PloS one 2010;5(4):e10099.
2009: Chee Wei Chia; Olga Carlson; Wook Kim; Yu-Kyong Shin; Cornelia P Charles; Hee Seung Kim; Denise L Melvin; Josephine M Egan
Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes.
Diabetes 2009;58(6):1342-9.
2009: Bronwen Martin; Stuart Maudsley; Caitlin M White; Josephine M Egan
Hormones in the naso-oropharynx: endocrine modulation of taste and smell.
Trends in endocrinology and metabolism: TEM 2009;20(4):163-70.
2009: Bronwen Martin; Erin Golden; Olga Carlson; Paul Pistell; Jie Zhou; Wook Kim; Brittany P Frank; Sam Thomas; Wayne A Chadwick; Nigel H Greig; Gillian P Bates; Kirupa Sathasivam; Michel Bernier; Stuart Maudsley; Mark P Mattson; Josephine M Egan
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.
Diabetes 2009;58(2):318-28.
2009: Yazhou Li; TracyAnn Perry; Mark S Kindy; Brandon K Harvey; David Tweedie; Harold W Holloway; Kathleen Powers; Hui Shen; Josephine M Egan; Kumar Sambamurti; Arnold Brossi; Debomoy K Lahiri; Mark P Mattson; Barry Hoffer; Yun Wang; Nigel H Greig
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1285-90.
2008: Wook Kim; Josephine M Egan
The role of incretins in glucose homeostasis and diabetes treatment.
Pharmacological reviews 2008;60(4):470-512.
2008: Yu-Kyong Shin; Bronwen Martin; Erin Golden; Cedrick D Dotson; Stuart Maudsley; Wook Kim; Hyeung-Jin Jang; Mark P Mattson; Daniel J Drucker; Josephine M Egan; Steven Munger
Modulation of taste sensitivity by GLP-1 signaling.
Journal of neurochemistry 2008;106(1):455-63.
2008: Bronwen Martin; Erin Golden; Olga Carlson; Josephine M Egan; Mark P Mattson; Stuart Maudsley
Caloric restriction: impact upon pituitary function and reproduction.
Ageing research reviews 2008;7(3):209-24.
2008: E Jeffrey Metter; B Gwen Windham; Marcello Maggio; Eleanor M Simonsick; Shari Miura Ling; Josephine M Egan; Luigi Ferrucci
Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.
Diabetes care 2008;31(5):1026-30.
2008: Josephine M Egan; Robert Margolskee
Taste cells of the gut and gastrointestinal chemosensation.
Molecular interventions 2008;8(2):78-81.
2008: Kevin J Pearson; Kaitlyn N Lewis; Nathan L Price; Joy W Chang; Evelyn Perez; Maria Victoria Cascajo; Kellie L K Tamashiro; Suresh Poosala; Anna Csiszar; Zoltan Ungvari; Thomas W Kensler; Masayuki Yamamoto; Josephine M Egan; Dan Longo; Donald Ingram; Plácido Navas; Rafael de Cabo
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2325-30.
2008: Bronwen Martin; Erin Golden; Alex Keselman; Matthew Stone; Mark P Mattson; Josephine M Egan; Stuart Maudsley
Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.
Histology and histopathology 2008;23(2):237-50.
2008: Alexis M Stranahan; Eric D Norman; Kim Lee; Roy G Cutler; Richard S Telljohann; Josephine M Egan; Mark P Mattson
Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.
Hippocampus 2008;18(11):1085-8.
2008: Bronwen Martin; Michele Pearson; Randall Brenneman; Erin Golden; Alex Keselman; Titilola Iyun; Olga Carlson; Josephine M Egan; Kevin G Becker; William Wood; Vinayakumar Prabhu; Rafael de Cabo; Stuart Maudsley; Mark P Mattson
Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.
PloS one 2008;3(6):e2398.
2007: Olga Carlson; Jehan D David; Jessica M Schrieder; Denis C Muller; Hyeung-Jin Jang; Byung-Joon Kim; Josephine M Egan
Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging.
Metabolism: clinical and experimental 2007;56(10):1444-51.
2007: Hyeung-Jin Jang; Zaza Kokrashvili; Michael J Theodorakis; Olga Carlson; Byung-Joon Kim; Jie Zhou; Hyeon Ho Kim; Xiangru Xu; Sic L Chan; Magdalena Juhaszova; Michel Bernier; Bedrich Mosinger; Robert Margolskee; Josephine M Egan
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15069-74.
2007: Jie Zhou; Mauren F A Livak; Michel Bernier; Denis C Muller; Olga Carlson; Dariush Elahi; Stuart Maudsley; Josephine M Egan
Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.
American journal of physiology. Endocrinology and metabolism 2007;293(2):E538-47.
2007: Maire Eileen Doyle; Josephine M Egan
Mechanisms of action of glucagon-like peptide 1 in the pancreas.
Pharmacology & therapeutics 2007;113(3):546-93.
2007: Marcello Maggio; Fulvio Lauretani; Gian Paolo Ceda; Stefania Bandinelli; Shehzad Basaria; Giuseppe Paolisso; Alessandro Ble; Josephine M Egan; E Jeffrey Metter; Angela Marie Abbatecola; Giovanni Zuliani; Carmelinda Ruggiero; Giorgio Valenti; Jack M Guralnik; Luigi Ferrucci
Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E353-8.
2006: Michael J Theodorakis; Olga Carlson; Spyros Michopoulos; Maire Eileen Doyle; Magdalena Juhaszova; Kalliopi Petraki; Josephine M Egan
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E550-9.
2005: Byung-Joon Kim; Olga Carlson; Hyeung-Jin Jang; Dariush Elahi; Carmen Berry; Josephine M Egan
Peptide YY is secreted after oral glucose administration in a gender-specific manner.
The Journal of clinical endocrinology and metabolism 2005;90(12):6665-71.
2005: Maire Eileen Doyle; Patrick McConville; Michael J Theodorakis; Margaret M Goetschkes; Michel Bernier; RICHARD SPENCER; Harold W Holloway; Nigel H Greig; Josephine M Egan
In vivo biological activity of exendin (1-30).
Endocrine 2005;27(1):1-9.
2004: Donald E Mager; Darrell R. Abernethy; Josephine M Egan; Dariush Elahi
Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique.
The Journal of pharmacology and experimental therapeutics 2004;311(2):830-5.
2004: Michael J Theodorakis; Olga Carlson; Denis C Muller; Josephine M Egan
Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance.
Diabetes care 2004;27(7):1692-8.
2003: Charles P Gilman; TracyAnn Perry; Katsotoshi Furukawa; Nigel H Grieg; Josephine M Egan; Mark P Mattson
Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons.
Journal of neurochemistry 2003;87(5):1137-44.
2003: Michael J Theodorakis; Denis C Muller; Olga Carlson; Josephine M Egan
Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose.
Metabolism: clinical and experimental 2003;52(11):1523-4; discussion 1524-5.
2003: Graydon S Meneilly; Nigel Greig; Hugh Tildesley; Joel F Habener; Josephine M Egan; Dariush Elahi
Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes.
Diabetes care 2003;26(10):2835-41.
2003: Alice S Ryan; Dora Berman-Weinberg; Barbara J Nicklas; Madhur Sinha; Ronald L Gingerich; Graydon S Meneilly; Josephine M Egan; Dariush Elahi
Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity.
Diabetes care 2003;26(8):2383-8.
2003: Maire Eileen Doyle; Michael J Theodorakis; Harold W Holloway; Michel Bernier; Nigel H Greig; Josephine M Egan
The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity.
Regulatory peptides 2003;114(2-3):153-8.
2003: TracyAnn Perry; Debomoy K Lahiri; Kumar Sambamurti; Demao Chen; Mark P Mattson; Josephine M Egan; Nigel H Greig
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.
Journal of neuroscience research 2003;72(5):603-12.
2003: Josephine M Egan; Graydon S Meneilly; Dariush Elahi
Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2003;284(6):E1072-9.
2003: Josephine M Egan; Angela Bulotta; Hongxiang Hui; Riccardo Perfetti
GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.
Diabetes/metabolism research and reviews 2003;19(2):115-23.
2003: Maire Eileen Doyle; Josephine M Egan
Pharmacological agents that directly modulate insulin secretion.
Pharmacological reviews 2003;55(1):105-31.
2003: Graydon S Meneilly; Christopher H S McIntosh; Raymond A Pederson; Joel F Habener; Mario R W Ehlers; Josephine M Egan; Dariush Elahi
Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.
Diabetes care 2003;26(3):837-42.
2002: TracyAnn Perry; Norman Haughey; Mark P Mattson; Josephine M Egan; Nigel H Greig
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
The Journal of pharmacology and experimental therapeutics 2002;302(3):881-8.
2002: Jie Zhou; Marco A Pineyro; Xiaolin Wang; Maire Eileen Doyle; Josephine M Egan
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors.
Journal of cellular physiology 2002;192(3):304-14.
2002: Josephine M Egan; Graydon S Meneilly; Joel F Habener; Dariush Elahi
Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state.
The Journal of clinical endocrinology and metabolism 2002;87(8):3768-73.
2002: Josephine M Egan; Astrid R Clocquet; Dariush Elahi
The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2002;87(3):1282-90.
2002: TracyAnn Perry; Debomoy K Lahiri; Demao Chen; Jie Zhou; Karen T Y Shaw; Josephine M Egan; Nigel H Greig
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.
The Journal of pharmacology and experimental therapeutics 2002;300(3):958-66.
2002: Dariush Elahi; Denis C Muller; Josephine M Egan; Reubin Andres; Johannes Veldhuist; Graydon S Meneilly
Glucose tolerance, glucose utilization and insulin secretion in ageing.
Novartis Foundation symposium 2002;242():222-42; discussion 242-6.
2001: Graydon S Meneilly; Christopher H S McIntosh; Raymond A Pederson; Joel F Habener; Ronald L Gingerich; Josephine M Egan; Dariush Elahi
Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(11):M681-5.
2001: Graydon S Meneilly; Christopher H S McIntosh; Raymond A Pederson; Joel F Habener; Ronald L Gingerich; Josephine M Egan; Diane T Finegood; Dariush Elahi
Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes.
Diabetes care 2001;24(11):1951-6.
2001: Maire Eileen Doyle; Nigel H Greig; Harold W Holloway; JA Betkey; Michel Bernier; Josephine M Egan
Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent.
Endocrinology 2001;142(10):4462-8.
2001: J Korosi; Christopher H S McIntosh; Raymond A Pederson; Hans-Ulrich Demuth; Joel F Habener; Ronald L Gingerich; Josephine M Egan; Dariush Elahi; Graydon S Meneilly
Effect of aging and diabetes on the enteroinsular axis.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(9):M575-9.
2001: Martín G Vila Petroff; Josephine M Egan; X Wang; STEVEN SOLLOTT
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes.
Circulation research 2001;89(5):445-52.
2001: Graydon S Meneilly; Christopher H S McIntosh; Raymond A Pederson; Joel F Habener; Ronald L Gingerich; Josephine M Egan; Dariush Elahi
Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes.
Diabetes care 2001;24(5):964-5.
2001: Xiaolin Wang; Jie Zhou; Maire Eileen Doyle; Josephine M Egan
Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism.
Endocrinology 2001;142(5):1820-7.
2001: Maire Eileen Doyle; Josephine M Egan
Glucagon-like peptide-1.
Recent progress in hormone research 2001;56():377-99.
2000: Riccardo Perfetti; Jie Zhou; Maire Eileen Doyle; Josephine M Egan
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats.
Endocrinology 2000;141(12):4600-5.
2000: A R Clocquet; Josephine M Egan; Doris A Stoffers; Denis C Muller; L Wideman; G A Chin; WL Clarke; JB Hanks; Joel F Habener; Dariush Elahi
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).
Diabetes 2000;49(11):1856-64.
2000: M Szayna; Maire Eileen Doyle; JA Betkey; Harold W Holloway; RICHARD SPENCER; Nigel H Greig; Josephine M Egan
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats.
Endocrinology 2000;141(6):1936-41.
2000: Doris A Stoffers; T J Kieffer; Mehboob A Hussain; D J Drucker; S Bonner-Weir; J F Habener; Josephine M Egan
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.
Diabetes 2000;49(5):741-8.
1999: Jie Zhou; Xiaolin Wang; Marco A Pineyro; Josephine M Egan
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.
Diabetes 1999;48(12):2358-66.
1999: Jie Zhou; C Montrose-Rafizadeh; Andrzej M Janczewski; Marco A Pineyro; STEVEN SOLLOTT; Y Wang; Josephine M Egan
Glucagon-like peptide-1 does not mediate amylase release from AR42J cells.
Journal of cellular physiology 1999;181(3):470-8.
1999: Xiaolin Wang; C M Cahill; M A Piñeyro; Jie Zhou; Maire Eileen Doyle; Josephine M Egan
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells.
Endocrinology 1999;140(10):4904-7.
1999: Y Wang; Whaseon L Kwon; Jennifer L Martindale; L Adams; P Heller; Josephine M Egan; Michel Bernier
Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes.
Endocrinology 1999;140(7):2938-47.
1999: Hyunwon Yang; Josephine M Egan; Buel D Rodgers; Michel Bernier; C Montrose-Rafizadeh
Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice.
Endocrinology 1999;140(6):2859-67.
1999: Nigel H Greig; Harold W Holloway; K A De Ore; D Jani; Y Wang; Jie Zhou; MJ Garant; Josephine M Egan
Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations.
Diabetologia 1999;42(1):45-50.
1998: Riccardo Perfetti; P S Barnett; R Mathur; Josephine M Egan
Novel therapeutic strategies for the treatment of type 2 diabetes.
Diabetes/metabolism reviews 1998;14(3):207-25.
1998: Hyunwon Yang; Josephine M Egan; Y Wang; C D Moyes; J Roth; MH Montrose; C Montrose-Rafizadeh
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.
The American journal of physiology 1998;275(3 Pt 1):C675-83.
1998: Alice S Ryan; Josephine M Egan; J F Habener; Dariush Elahi
Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia.
The Journal of clinical endocrinology and metabolism 1998;83(7):2399-404.
1997: William C Wallace; CA Akar; W Ernest Lyons; HK Kole; Josephine M Egan; Benjamin Wolozin
Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity.
Brain research. Molecular brain research 1997;52(2):213-27.
1997: Y Wang; HK Kole; C Montrose-Rafizadeh; Riccardo Perfetti; Michel Bernier; Josephine M Egan
Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions.
Journal of molecular endocrinology 1997;19(3):241-8.
1997: K De Ore; Nigel H Greig; Harold W Holloway; Y Wang; Riccardo Perfetti; Josephine M Egan
The effects of GLP-1 on insulin release in young and old rats in the fasting state and during an intravenous glucose tolerance test.
The journals of gerontology. Series A, Biological sciences and medical sciences 1997;52(5):B245-9.
1997: C Montrose-Rafizadeh; Y Wang; Andrzej M Janczewski; T E Henderson; Josephine M Egan
Overexpression of glucagon-like peptide-1 receptor in an insulin-secreting cell line enhances glucose responsiveness.
Molecular and cellular endocrinology 1997;130(1-2):109-17.
1997: Y Wang; Riccardo Perfetti; Nigel H Greig; Harold W Holloway; K A DeOre; C Montrose-Rafizadeh; Dariush Elahi; Josephine M Egan
Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.
The Journal of clinical investigation 1997;99(12):2883-9.
1996: Riccardo Perfetti; Y Wang; Alan R Shuldiner; Josephine M Egan
Molecular investigation of age-related changes in mouse endocrine pancreas.
The journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(5):B331-6.
1996: Riccardo Perfetti; Josephine M Egan; Michael E Zenilman; Alan R Shuldiner
Differential expression of reg-I and reg-II genes during aging in the normal mouse.
The journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(5):B308-15.
1996: Riccardo Perfetti; M Raygada; Y Wang; Michael E Zenilman; Josephine M Egan; K M Denno; Thomas W Sadler; Alan R Shuldiner
Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos.
Journal of molecular endocrinology 1996;17(1):79-88.
1996: Riccardo Perfetti; T E Henderson; Y Wang; C Montrose-Rafizadeh; Josephine M Egan
Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix.
Pancreas 1996;13(1):47-54.
1996: Y Wang; C Montrose-Rafizadeh; L Adams; M Raygada; O Nadiv; Josephine M Egan
GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells.
Molecular and cellular endocrinology 1996;116(1):81-7.
1995: Riccardo Perfetti; C M Rafizadeh; A S Liotta; Josephine M Egan
Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats.
The American journal of physiology 1995;269(6 Pt 1):E983-90.
1995: Y Wang; Josephine M Egan; M Raygada; O Nadiv; J Roth; C Montrose-Rafizadeh
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells.
Endocrinology 1995;136(11):4910-7.
1995: Josephine M Egan; T E Henderson; Michel Bernier
Arginine enhances glycogen synthesis in response to insulin in 3T3-L1 adipocytes.
The American journal of physiology 1995;269(1 Pt 1):E61-6.
1994: Josephine M Egan; C Montrose-Rafizadeh; Y Wang; Michel Bernier; J Roth
Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.
Endocrinology 1994;135(5):2070-5.
1994: C Montrose-Rafizadeh; Josephine M Egan; J Roth
Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.
Endocrinology 1994;135(2):589-94.
1994: Riccardo Perfetti; Josephine M Egan; Michael E Zenilman; Alan R Shuldiner
Expression of the regenerating gene in the pancreas of aging mice.
Transplantation proceedings 1994;26(2):733.
1994: Riccardo Perfetti; Anita L Hawkins; Constance A Griffin; Josephine M Egan; Michael E Zenilman; Alan R Shuldiner
Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12.
Genomics 1994;20(2):305-7.