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Edmond Eger

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George Mychaskiw; Edmond I Eger
A different perspective on anesthetics and climate change.
Edmond I Eger
Maybe it isn't aging.
Cecilia Borghese; Edmond I Eger; Angel Ho; Gregg E Homanics; David M Lovinger; S John Mihic; S Irene Oh; Wei Xiong; Li Zhang; R Adron Harris
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

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All Publications

2013: George Mychaskiw; Edmond I Eger
A different perspective on anesthetics and climate change.
Anesthesia and analgesia 2013;116(3):734.
2012: Edmond I Eger
Maybe it isn't aging.
Anesthesiology 2012;117(5):1138-9; author reply 1139-40.
2012: Cecilia Borghese; Edmond I Eger; Angel Ho; Gregg E Homanics; David M Lovinger; S John Mihic; S Irene Oh; Wei Xiong; Li Zhang; R Adron Harris
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.
Anesthesiology 2012;117(4):765-71.
2011: Vinuta Rau; James M Sonner; Christina Bodarky; Michael S Fanselow; Gregg E Homanics; Mark Liao; Irene Oh; Edmond I Eger
Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.
Anesthesia and analgesia 2011;113(3):500-4.
2011: William Burns Burns; Edmond I Eger
Ross C. Terrell, PhD, an anesthetic pioneer.
Anesthesia and analgesia 2011;113(2):387-9.
2011: David F Werner; A Swihart; V Rau; F Jia; Cecilia Borghese; M L McCracken; S Iyer; Michael S Fanselow; I Oh; James M Sonner; Edmond I Eger; Neil L Harrison; R Adron Harris; Gregg E Homanics
Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.
The Journal of pharmacology and experimental therapeutics 2011;336(1):134-44.
2010: Misha Perouansky; Vinuta Rau; Tim Ford; S Irene Oh; Mark Perkins; Edmond I Eger; Robert A Pearce
Slowing of the hippocampal θ rhythm correlates with anesthetic-induced amnesia.
Anesthesiology 2010;113(6):1299-309.
2010: David Speca; Daisuke Chihara; Amir M Ashique; M Scott Bowers; Jonathan T Pierce-Shimomura; Jungsoo Lee; Nusrat Rabbee; Terence P Speed; Rodrigo J Gularte; James Chitwood; Juan F Medrano; Mark Liao; James M Sonner; Edmond I Eger; Andrew S Peterson; Steven L McIntire
Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
PLoS genetics 2010;6(8):.
2010: Igor Ponomarev; Vinuta Rau; Edmond I Eger; R Adron Harris; Michael S Fanselow
Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(6):1402-11.
2010: Edmond I Eger
After you, please: the second Annual John W. Severinghaus Lecture on Translational Science.
Anesthesiology 2010;112(4):786-93.
2010: Y Zhang; M Guzinski; Edmond I Eger; Michael J Laster; Manohar Sharma; R Adron Harris; H C Hemmings
Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.
British journal of pharmacology 2010;159(4):872-8.
2010: Edmond I Eger
Cost in several flavors.
Anesthesia and analgesia 2010;110(2):276-7.
2009: Vinuta Rau; Sangeetha V Iyer; Irene Oh; Dev Chandra; Neil Harrison; Edmond I Eger; Michael S Fanselow; Gregg E Homanics; James M Sonner
Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
Anesthesia and analgesia 2009;109(6):1816-22.
2009: Greg Stratmann; Jeffrey W Sall; Edmond I Eger; Michael J Laster; Joseph S Bell; Laura D V May; Helge Eilers; Martin Krause; Frank v d Heusen; Heidi E Gonzalez
Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats.
Anesthesia and analgesia 2009;109(3):801-6.
2009: Vinuta Rau; Irene Oh; Michael J Laster; Edmond I Eger; Michael S Fanselow
Isoflurane suppresses stress-enhanced fear learning in a rodent model of post-traumatic stress disorder.
Anesthesiology 2009;110(3):487-95.
2008: R Adron Harris; Edmond I Eger
Alzheimer's disease and anesthesia: out of body, out of mind...or not?
Annals of neurology 2008;64(6):595-7.
2008: Harry J M Lemmens; Lawrence J Saidman; Edmond I Eger; Michael J Laster
Obesity modestly affects inhaled anesthetic kinetics in humans.
Anesthesia and analgesia 2008;107(6):1864-70.
2008: C Spencer Yost; Irene Oh; Edmond I Eger; James M Sonner
Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.
Behavioural brain research 2008;193(2):192-6.
2008: Takafumi Horishita; Edmond I Eger; R Adron Harris
The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes.
Anesthesia and analgesia 2008;107(5):1579-86.
2008: Dimitry Shnayderman; Michael J Laster; Edmond I Eger; Irene Oh; Yi Zhang; Steven L Jinks; Joseph F Antognini; Douglas Raines
Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.
Anesthesia and analgesia 2008;107(3):879-84.
2008: Yi Zhang; Manohar Sharma; Edmond I Eger; Michael J Laster; Hugh C Hemmings; R Adron Harris
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
Anesthesia and analgesia 2008;107(3):875-8.
2008: Edmond I Eger; Douglas Raines; Steven Shafer; Hugh C Hemmings; James M Sonner
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Anesthesia and analgesia 2008;107(3):832-48.
2008: Steven Shafer; Jan F A Hendrickx; Pamela Flood; James M Sonner; Edmond I Eger
Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.
Anesthesia and analgesia 2008;107(2):507-24.
2008: Jan F A Hendrickx; Edmond I Eger; James M Sonner; Steven Shafer
Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.
Anesthesia and analgesia 2008;107(2):494-506.
2008: Andrew Jenkins; Ingrid A Lobo; Diane Gong; James R Trudell; Ken Solt; R Adron Harris; Edmond I Eger
General anesthetics have additive actions on three ligand gated ion channels.
Anesthesia and analgesia 2008;107(2):486-93.
2008: Edmond I Eger; Michael Tang; Mark Liao; Michael J Laster; Ken Solt; Pamela Flood; Andrew Jenkins; Douglas Raines; Jan F Hendrickx; Steven Shafer; Tanifuji Yasumasa; James M Sonner
Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
Anesthesia and analgesia 2008;107(2):479-85.
2008: Jing Zhao; Yi Zhang; Edmond I Eger; James Sonner
Intrathecal glycine significantly decreases the minimum alveolar concentration of isoflurane in rats.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 2008;23(1):16-8.
2007: Edmond I Eger
The ever-useful infrared analyzer.
Anesthesia and analgesia 2007;105(6):1869.
2007: Charles W Buffington; Michael J Laster; Katarzyna Jankowska; Edmond I Eger
Concentrations of isoflurane exceeding those used clinically slightly increase the affinity of methane, but not toluene, for water.
Anesthesia and analgesia 2007;105(6):1675-80, table of contents.
2007: Robert C Dutton; Jason M Cuellar; Edmond I Eger; Joseph F Antognini; Earl Carstens
Temporal and spatial determinants of sacral dorsal horn neuronal windup in relation to isoflurane-induced immobility.
Anesthesia and analgesia 2007;105(6):1665-74, table of contents.
2007: Cecilia M Rosales; Thomas Young; Michael J Laster; Edmond I Eger; Uttam Garg
Sevoflurane concentrations in blood, brain, and lung after sevoflurane-induced death.
Journal of forensic sciences 2007;52(6):1408-10.
2007: Liya Yang; Jing Zhao; Pavle S Milutinovic; Robert J Brosnan; Edmond I Eger; James M Sonner
Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.
Anesthesia and analgesia 2007;105(3):673-9.
2007: Michael J Laster; Yi Zhang; Edmond I Eger; Dimitry Shnayderman; James M Sonner
Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats.
Anesthesia and analgesia 2007;105(3):661-5.
2007: Liya Yang; Pavle S Milutinovic; Robert J Brosnan; Edmond I Eger; James M Sonner
The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function.
Anesthesia and analgesia 2007;105(2):393-6.
2007: Pavle S Milutinovic; Liya Yang; Robert S Cantor; Edmond I Eger; James M Sonner
Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters.
Anesthesia and analgesia 2007;105(2):386-92.
2007: Michael Cascio; Yilei Xing; Diane Gong; John Popovich; Edmond I Eger; Saunak Sen; Gary Peltz; James M Sonner
Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration.
Anesthesia and analgesia 2007;105(2):381-5.
2007: Edmond I Eger
Brain magnetic resonance imaging increases core body temperature in sedated children.
Anesthesia and analgesia 2007;105(1):283; author reply 283.
2007: Robert J Brosnan; Edmond I Eger; Michael J Laster; James M Sonner
Anesthetic properties of carbon dioxide in the rat.
Anesthesia and analgesia 2007;105(1):103-6.
2007: James S Anderson; Noel R Rose; Jackie L Martin; Edmond I Eger; Dolores B Njoku
Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies.
Anesthesia and analgesia 2007;104(6):1452-3, table of contents.
2007: Robert J Brosnan; Liya Yang; Pavle S Milutinovic; Jing Zhao; Michael J Laster; Edmond I Eger; James M Sonner
Ammonia has anesthetic properties.
Anesthesia and analgesia 2007;104(6):1430-3, table of contents.
2007: Yi Zhang; Michael J Laster; Edmond I Eger; Manohar Sharma; James M Sonner
Lidocaine, MK-801, and MAC.
Anesthesia and analgesia 2007;104(5):1098-102, tables of contents.
2007: Edmond I Eger; David Lemal; Michael J Laster; Mark Liao; Katarzyna Jankowska; Anilkumar Raghavanpillai; Anatoliy V Popov; Yonghong Gan; Yan Lou
Anesthetic properties of some fluorinated oxolanes and oxetanes.
Anesthesia and analgesia 2007;104(5):1090-7, tables of contents.
2007: Yi Zhang; Michael J Laster; Edmond I Eger; Manohar Sharma; James M Sonner
Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats.
Anesthesia and analgesia 2007;104(4):850-2.
2007: Joseph F Antognini; Richard J Atherley; Robert C Dutton; Michael J Laster; Edmond I Eger; Earl Carstens
The excitatory and inhibitory effects of nitrous oxide on spinal neuronal responses to noxious stimulation.
Anesthesia and analgesia 2007;104(4):829-35.
2007: Joseph F Antognini; Douglas Raines; Ken Solt; Linda S Barter; Richard J Atherley; Emigdio Bravo; Michael J Laster; Katarzyna Jankowska; Edmond I Eger
Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.
Anesthesia and analgesia 2007;104(4):822-8.
2007: Joseph F Antognini; Richard J Atherley; Michael J Laster; Earl Carstens; Robert C Dutton; Edmond I Eger
A method for recording single unit activity in lumbar spinal cord in rats anesthetized with nitrous oxide in a hyperbaric chamber.
Journal of neuroscience methods 2007;160(2):215-22.
2007: Claudia Benkwitz; Mark Liao; Michael J Laster; James M Sonner; Edmond I Eger; Robert A Pearce
Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.
Anesthesiology 2007;106(1):114-23.
2007: James M Sonner; David F Werner; Frank Peter Elsen; Yilei Xing; Mark Liao; R Adron Harris; Neil L Harrison; Michael S Fanselow; Edmond I Eger; Gregg E Homanics
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.
Anesthesiology 2007;106(1):107-13.
2006: Yasumasa Tanifuji; Yi Zhang; Mark Liao; Edmond I Eger; Michael J Laster; James M Sonner
Do dopamine receptors mediate part of MAC?
Anesthesia and analgesia 2006;103(5):1177-81.
2006: Austin W Merrill; Linda S Barter; Uwe Rudolph; Edmond I Eger; Joseph F Antognini; Mirela Iodi Carstens; Earl Carstens
Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit.
Anesthesia and analgesia 2006;103(2):478-83, table of contents.
2006: Robert J Brosnan; Diane Gong; Joseph F Cotten; Bharat Keshavaprasad; C Spencer Yost; Edmond I Eger; James M Sonner
Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers.
Anesthesia and analgesia 2006;103(1):86-91, table of contents.
2006: Albert Won; Irene Oh; Michael J Laster; John Popovich; Edmond I Eger; James M Sonner
Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers.
Anesthesia and analgesia 2006;103(1):81-4, table of contents.
2006: Mark Liao; Michael J Laster; Edmond I Eger; Michael Tang; James M Sonner
Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice.
Anesthesia and analgesia 2006;102(5):1452-5.
2006: Albert Won; Irene Oh; Mark Liao; James M Sonner; R Adron Harris; Michael J Laster; Robert J Brosnan; James R Trudell; Edmond I Eger
The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms.
Anesthesia and analgesia 2006;102(5):1419-26.
2006: Robert C Dutton; Michael J Laster; Yilei Xing; James M Sonner; Douglas Raines; Ken Solt; Edmond I Eger
Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
Anesthesia and analgesia 2006;102(5):1412-8.
2006: Ken Solt; Edmond I Eger; Douglas Raines
Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics.
Anesthesia and analgesia 2006;102(5):1407-11.
2006: Edmond I Eger; Mark Liao; Michael J Laster; Albert Won; John Popovich; Douglas Raines; Ken Solt; Robert C Dutton; Franklin V Cobos; James M Sonner
Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.
Anesthesia and analgesia 2006;102(5):1397-406.
2006: Edmond I Eger; James M Sonner
Anaesthesia defined (gentlemen, this is no humbug).
Best practice & research. Clinical anaesthesiology 2006;20(1):23-9.
2006: Joseph F Cotten; Bharat Keshavaprasad; Michael J Laster; Edmond I Eger; C Spencer Yost
The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration.
Anesthesia and analgesia 2006;102(3):779-85.
2006: Albert Won; Irene Oh; Robert J Brosnan; Edmond I Eger; James M Sonner
Hypothermia decreases ethanol MAC in rats.
Journal of anesthesia 2006;20(3):247-50.
2005: Edmond I Eger; Steven Shafer
The complexity of recovery from anesthesia.
Journal of clinical anesthesia 2005;17(6):411-2.
2005: Michael J Laster; Edmond I Eger
Temperatures in soda lime during degradation of desflurane, isoflurane, and sevoflurane by desiccated soda lime.
Anesthesia and analgesia 2005;101(3):753-7, table of contents.
2005: Edmond I Eger; Steven Shafer
Tutorial: context-sensitive decrement times for inhaled anesthetics.
Anesthesia and analgesia 2005;101(3):688-96, table of contents.
2005: Mark Liao; James M Sonner; Rachel Jurd; Uwe Rudolph; Cecilia Borghese; R Adron Harris; Michael J Laster; Edmond I Eger
Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.
Anesthesia and analgesia 2005;101(2):412-8, table of contents.
2005: James M Sonner; Bryce Vissel; Gordon A Royle; Anya Maurer; Diane Gong; Nicole V Baron; Neil Harrison; Michael S Fanselow; Edmond I Eger
The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene.
Anesthesia and analgesia 2005;101(1):143-8, table of contents.
2005: Mark Liao; James M Sonner; S Shaukat Husain; Keith W Miller; Rachel Jurd; Uwe Rudolph; Edmond I Eger
R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit.
Anesthesia and analgesia 2005;101(1):131-5, table of contents.
2005: James M Sonner; Mike Cascio; Yilei Xing; Michael S Fanselow; Jason E Kralic; A Leslie Morrow; Esa R Korpi; Steven Hardy; Brian Sloat; Edmond I Eger; Gregg E Homanics
Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear.
Molecular pharmacology 2005;68(1):61-8.
2005: Edmond I Eger; James M Sonner
How likely is awareness during anesthesia?
Anesthesia and analgesia 2005;100(5):1544; author reply 1545.
2005: James M Sonner; Yilei Xing; Yi Zhang; Anya Maurer; Michael S Fanselow; Robert C Dutton; Edmond I Eger
Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane.
Anesthesia and analgesia 2005;100(5):1333-7, table of contents.
2005: Edmond I Eger; Lawrence J Saidman
Illustrations of inhaled anesthetic uptake, including intertissue diffusion to and from fat.
Anesthesia and analgesia 2005;100(4):1020-33.
2005: Mireille A Neumann; Edmond I Eger; Richard B Weiskopf
Solubility of volatile anesthetics in bovine white matter, cortical gray matter, thalamus, hippocampus, and hypothalamic area.
Anesthesia and analgesia 2005;100(4):1003-6.
2005: Caroline R Stabernack; Yi Zhang; James M Sonner; Michael J Laster; Edmond I Eger
Thiopental produces immobility primarily by supraspinal actions in rats.
Anesthesia and analgesia 2005;100(1):128-36.
2004: Hildebrand S Schwab; Manfred D Seeberger; Edmond I Eger; Christoph H Kindler; Miodrag Filipovic
Sevoflurane decreases bispectral index values more than does halothane at equal MAC multiples.
Anesthesia and analgesia 2004;99(6):1723-7, table of contents.
2004: Steven L Jinks; Joseph F Antognini; Robert C Dutton; Earl Carstens; Edmond I Eger
Isoflurane depresses windup of C fiber-evoked limb withdrawal with variable effects on nociceptive lumbar spinal neurons in rats.
Anesthesia and analgesia 2004;99(5):1413-9; table of contents.
2004: Edmond I Eger
Characteristics of anesthetic agents used for induction and maintenance of general anesthesia.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2004;61 Suppl 4():S3-10.
2004: Michael J Laster; Patricia Roth; Edmond I Eger
Fires from the interaction of anesthetics with desiccated absorbent.
Anesthesia and analgesia 2004;99(3):769-74, table of contents.
2004: Yilei Xing; James M Sonner; Edmond I Eger; Michael Cascio; Daniel Sessler
Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
Anesthesiology 2004;101(2):544-6.
2004: Yi Zhang; James M Sonner; Edmond I Eger; Caroline R Stabernack; Michael J Laster; Douglas Raines; R Adron Harris
Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
Anesthesia and analgesia 2004;99(1):85-90.
2004: Jennifer A Shumilla; Sarah M Sweitzer; Edmond I Eger; Michael J Laster; Joan J Kendig
Inhibition of spinal protein kinase C-epsilon or -gamma isozymes does not affect halothane minimum alveolar anesthetic concentration in rats.
Anesthesia and analgesia 2004;99(1):82-4.
2004: Jason M Cuellar; Joseph F Antognini; Edmond I Eger; Earl Carstens
Halothane depresses C-fiber-evoked windup of deep dorsal horn neurons in mice.
Neuroscience letters 2004;363(3):207-11.
2004: Yilei Xing; James M Sonner; Michael J Laster; Wella Abaigar; Valerie B Caraiscos; Beverley A Orser; Edmond I Eger
Insulin decreases isoflurane minimum alveolar anesthetic concentration in rats independently of an effect on the spinal cord.
Anesthesia and analgesia 2004;98(6):1712-7, table of contents.
2003: Edmond I Eger; Michael J Laster; George A Gregory; Takasumi Katoh; James M Sonner
Women appear to have the same minimum alveolar concentration as men: a retrospective study.
Anesthesiology 2003;99(5):1059-61.
2003: Yilei Xing; Yi Zhang; Caroline R Stabernack; Edmond I Eger; Andrew T Gray
The use of the potassium channel activator riluzole to test whether potassium channels mediate the capacity of isoflurane to produce immobility.
Anesthesia and analgesia 2003;97(4):1020-4, table of contents.
2003: Lawrence J Saidman; Edmond I Eger
Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.
Anesthesiology 2003;99(3):752; author reply 752-4.
2003: James M Sonner; Joseph F Antognini; Robert C Dutton; Pamela Flood; Andrew T Gray; R Adron Harris; Gregg E Homanics; Joan J Kendig; Beverley A Orser; Douglas Raines; Ira J Rampil; James R Trudell; Bryce Vissel; Edmond I Eger
Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
Anesthesia and analgesia 2003;97(3):718-40.
2003: Yi Zhang; Michael J Laster; Edmond I Eger; Caroline R Stabernack; James M Sonner
Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics.
Anesthesia and analgesia 2003;97(2):475-9, table of contents.
2003: Robert C Dutton; Yi Zhang; Caroline R Stabernack; Michael J Laster; James M Sonner; Edmond I Eger
Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia.
Anesthesiology 2003;98(6):1372-7.
2003: Edmond I Eger; Yilei Xing; Michael J Laster; James M Sonner
Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics.
Anesthesia and analgesia 2003;96(6):1661-4, table of contents.
2003: Edmond I Eger; Yilei Xing; Michael J Laster; James M Sonner; Joseph F Antognini; Earl Carstens
Halothane and isoflurane have additive minimum alveolar concentration (MAC) effects in rats.
Anesthesia and analgesia 2003;96(5):1350-3, table of contents.
2003: Karin M Gerstin; Diane H Gong; Mona Abdallah; Bruce D Winegar; Edmond I Eger; Andrew T Gray
Mutation of KCNK5 or Kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration.
Anesthesia and analgesia 2003;96(5):1345-9, table of contents.
2003: Edmond I Eger; Yilei Xing; Robert Pearce; Steven Shafer; Michael J Laster; Yi Zhang; Michael S Fanselow; James M Sonner
Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone.
Anesthesia and analgesia 2003;96(4):1010-8, table of contents.
2003: Caroline R Stabernack; Edmond I Eger; Uwe H Warnken; Harald Förster; Douglas K Hanks; Linda D Ferrell
Sevoflurane degradation by carbon dioxide absorbents may produce more than one nephrotoxic compound in rats.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 2003;50(3):249-52.
2003: Caroline R Stabernack; James M Sonner; Michael J Laster; Yi Zhang; Yilei Xing; Manohar Sharma; Edmond I Eger
Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane.
Anesthesia and analgesia 2003;96(1):102-7, table of contents.
2003: Yi Zhang; Michael J Laster; Koji Hara; R Adron Harris; Edmond I Eger; Caroline R Stabernack; James M Sonner
Glycine receptors mediate part of the immobility produced by inhaled anesthetics.
Anesthesia and analgesia 2003;96(1):97-101, table of contents.
2002: Koji Hara; Edmond I Eger; Michael J Laster; R Adron Harris
Nonhalogenated alkanes cyclopropane and butane affect neurotransmitter-gated ion channel and G-protein-coupled receptors: differential actions on GABAA and glycine receptors.
Anesthesiology 2002;97(6):1512-20.
2002: Edmond I Eger; Diane Gong; Yilei Xing; Douglas Raines; Pamela Flood
Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.
Anesthesia and analgesia 2002;95(6):1611-5, table of contents.
2002: Claus U Niemann; Caroline R Stabernack; Natalie J Serkova; Wolfgang Jacobsen; Uwe Christians; Edmond I Eger
Cyclosporine can increase isoflurane MAC.
Anesthesia and analgesia 2002;95(4):930-4, table of contents.
2002: Edmond I Eger; Yi Zhang; Michael J Laster; Pamela Flood; Joan J Kendig; James M Sonner
Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics.
Anesthesia and analgesia 2002;94(6):1500-4, table of contents.
2002: Robert C Dutton; Anya Maurer; James M Sonner; Michael S Fanselow; Michael J Laster; Edmond I Eger
Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning.
Anesthesiology 2002;96(5):1223-9.
2002: Edmond I Eger
Propofol, metabisulfite, and bronchoconstriction.
Anesthesiology 2002;96(3):771-2; author reply 772-3.
2002: Robert C Dutton; Anya Maurer; James M Sonner; Michael S Fanselow; Michael J Laster; Edmond I Eger
Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory.
Anesthesia and analgesia 2002;94(3):631-9; table of contents.
2002: Edmond I Eger
Good news, bad news.
Anesthesia and analgesia 2002;94(2):239-40.
2002: Edmond I Eger
A brief history of the origin of minimum alveolar concentration (MAC).
Anesthesiology 2002;96(1):238-9.
2001: Y Zhang; Caroline R Stabernack; R Dutton; James M Sonner; James R Trudell; S John Mihic; T Yamakura; R Adron Harris; Diane Gong; Edmond I Eger
Luciferase as a model for the site of inhaled anesthetic action.
Anesthesia and analgesia 2001;93(5):1246-52.
2001: Edmond I Eger
Age, minimum alveolar anesthetic concentration, and minimum alveolar anesthetic concentration-awake.
Anesthesia and analgesia 2001;93(4):947-53.
2001: Edmond I Eger; MJ Halsey; DD Koblin; Michael J Laster; P Ionescu; K Königsberger; R Fan; B V Nguyen; T Hudlicky
The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene.
Anesthesia and analgesia 2001;93(4):922-7.
2001: Ira J Rampil; Michael J Laster; Edmond I Eger
Antagonism of the 5-HT(3) receptor does not alter isoflurane MAC in rats.
Anesthesiology 2001;95(2):562-4.
2001: Y Zhang; Caroline R Stabernack; James M Sonner; R Dutton; Edmond I Eger
Both cerebral GABA(A) receptors and spinal GABA(A) receptors modulate the capacity of isoflurane to produce immobility.
Anesthesia and analgesia 2001;92(6):1585-9.
2001: Edmond I Eger; Michael J Laster
The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons.
Anesthesia and analgesia 2001;92(6):1477-82.
2001: Edmond I Eger; Dennis M Fisher; J P Dilger; James M Sonner; A Evers; Nicholas P Franks; R Adron Harris; Joan J Kendig; William R Lieb; T Yamakura
Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms.
Anesthesiology 2001;94(5):915-21.
2001: Robert C Dutton; Anya Maurer; James M Sonner; Michael S Fanselow; Michael J Laster; Edmond I Eger
The concentration of isoflurane required to suppress learning depends on the type of learning.
Anesthesiology 2001;94(3):514-9.
2001: Y Zhang; S Wu; Edmond I Eger; James M Sonner
Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane.
Anesthesia and analgesia 2001;92(1):123-7.
2000: Y Zhang; James R Trudell; Maria Paola Mascia; Michael J Laster; Diane H Gong; R Adron Harris; Edmond I Eger
The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.
Anesthesia and analgesia 2000;91(5):1294-9.
2000: Maria Paola Mascia; Diane H Gong; Edmond I Eger; R Adron Harris
The anesthetic potency of propanol and butanol versus propanethiol and butanethiol in alpha1 wild type and alpha1(S267Q) glycine receptors.
Anesthesia and analgesia 2000;91(5):1289-93.
2000: Anya Maurer; Daniel Sessler; Edmond I Eger; James M Sonner
The nonimmobilizer 1,2-dichlorohexafluorocyclobutane does not affect thermoregulation in the rat.
Anesthesia and analgesia 2000;91(4):1013-6.
2000: Michael J Laster; Edmond I Eger; W R Cherry; Diane Gong
Fractional distillation of acid contaminants from sevoflurane.
Anesthesia and analgesia 2000;91(4):985-8.
2000: James M Sonner; Diane Gong; Edmond I Eger
Naturally occurring variability in anesthetic potency among inbred mouse strains.
Anesthesia and analgesia 2000;91(3):720-6.
2000: Y Zhang; Edmond I Eger; Robert C Dutton; James M Sonner
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Anesthesia and analgesia 2000;91(2):462-6.
2000: Michael J Beckstead; Jeff Weiner; Edmond I Eger; Diane H Gong; S John Mihic
Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse.
Molecular pharmacology 2000;57(6):1199-205.
2000: Caroline R Stabernack; Ronald Brown; Michael J Laster; Rafael Dudziak; Edmond I Eger
Absorbents differ enormously in their capacity to produce compound A and carbon monoxide.
Anesthesia and analgesia 2000;90(6):1428-35.
2000: Edmond I Eger; P F White; Martin S Bogetz
Clinical and economic factors important to anaesthetic choice for day-case surgery.
PharmacoEconomics 2000;17(3):245-62.
2000: Robert C Dutton; Ira J Rampil; Edmond I Eger
Inhaled nonimmobilizers do not alter the middle latency auditory-evoked response of rats.
Anesthesia and analgesia 2000;90(1):213-7.
1999: Robert C Dutton; W D Smith; Ira J Rampil; B S Chortkoff; Edmond I Eger
Forty-hertz midlatency auditory evoked potential activity predicts wakeful response during desflurane and propofol anesthesia in volunteers.
Anesthesiology 1999;91(5):1209-20.
1999: D M Taylor; Edmond I Eger; Philip E Bickler
Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats.
Anesthesia and analgesia 1999;89(4):1040-5.
1999: James M Sonner; Diane Gong; J Li; Edmond I Eger; Michael J Laster
Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds.
Anesthesia and analgesia 1999;89(4):1030-4.
1999: S Taheri; Edmond I Eger
A demonstration of the concentration and second gas effects in humans anesthetized with nitrous oxide and desflurane.
Anesthesia and analgesia 1999;89(3):774-80.
1999: Mireille A Neumann; Michael J Laster; Richard B Weiskopf; Diane H Gong; Rafael Dudziak; Harald Förster; Edmond I Eger
The elimination of sodium and potassium hydroxides from desiccated soda lime diminishes degradation of desflurane to carbon monoxide and sevoflurane to compound A but does not compromise carbon dioxide absorption.
Anesthesia and analgesia 1999;89(3):768-73.
1999: Edmond I Eger; MJ Halsey; R Adron Harris; DD Koblin; A Pohorille; J C Sewell; James M Sonner; James R Trudell
Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.
Anesthesia and analgesia 1999;88(6):1395-400.
1999: DD Koblin; Michael J Laster; P Ionescu; Diane Gong; Edmond I Eger; MJ Halsey; T Hudlicky
Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties.
Anesthesia and analgesia 1999;88(5):1161-7.
1999: Edmond I Eger; DD Koblin; James M Sonner; Diane Gong; Michael J Laster; P Ionescu; MJ Halsey; T Hudlicky
Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms.
Anesthesia and analgesia 1999;88(4):884-92.
1999: S Ueno; James R Trudell; Edmond I Eger; R Adron Harris
Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.
Anesthesia and analgesia 1999;88(4):877-83.
1999: Edmond I Eger; P Ionescu; Michael J Laster; Diane Gong; T Hudlicky; Joan J Kendig; R Adron Harris; James R Trudell; A Pohorille
Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.
Anesthesia and analgesia 1999;88(4):867-76.
1998: James M Sonner; J Li; L Kandel; Edmond I Eger
Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats.
Anesthesia and analgesia 1998;87(6):1398-403.
1998: Diane Gong; Z Fang; P Ionescu; Michael J Laster; R C Terrell; Edmond I Eger
Rat strain minimally influences anesthetic and convulsant requirements of inhaled compounds in rats.
Anesthesia and analgesia 1998;87(4):963-6.
1998: DD Koblin; Z Fang; Edmond I Eger; Michael J Laster; Diane Gong; P Ionescu; MJ Halsey; James R Trudell
Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics)
Anesthesia and analgesia 1998;87(2):419-24.
1998: James R Trudell; DD Koblin; Edmond I Eger
A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action.
Anesthesia and analgesia 1998;87(2):411-8.
1998: James M Sonner; J Li; Edmond I Eger
Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation.
Anesthesia and analgesia 1998;87(1):200-5.
1998: Edmond I Eger; P Ionescu; Diane Gong
Circuit absorption of halothane, isoflurane, and sevoflurane.
Anesthesia and analgesia 1998;86(5):1070-4.
1998: Mireille A Neumann; Richard B Weiskopf; Diane H Gong; Edmond I Eger; P Ionescu
Changing from isoflurane to desflurane toward the end of anesthesia does not accelerate recovery in humans.
Anesthesiology 1998;88(4):914-21.
1998: James M Sonner; J Li; Edmond I Eger
Desflurane and nitrous oxide, but not nonimmobilizers, affect nociceptive responses.
Anesthesia and analgesia 1998;86(3):629-34.
1998: Edmond I Eger; Diane Gong; DD Koblin; T Bowland; P Ionescu; Michael J Laster; Richard B Weiskopf
The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers.
Anesthesia and analgesia 1998;86(2):414-21.
1998: M Daniel; Richard B Weiskopf; M Noorani; Edmond I Eger
Fentanyl augments the blockade of the sympathetic response to incision (MAC-BAR) produced by desflurane and isoflurane: desflurane and isoflurane MAC-BAR without and with fentanyl.
Anesthesiology 1998;88(1):43-9.
1998: Diane H Gong; Richard B Weiskopf; Mireille A Neumann; Michael J Laster; Edmond I Eger
In rats breathing from a nonrebreathing system, substitution of desflurane for isoflurane toward the end of anesthesia incompletely restores the time of recovery toward that of desflurane.
Anesthesia and analgesia 1998;86(1):198-201.
1998: Eugene P Steffey; Michael J Laster; P Ionescu; Edmond I Eger; N Emerson
Ventilatory effects of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (2N) in swine.
Anesthesia and analgesia 1998;86(1):173-8.
1997: Eugene P Steffey; Michael J Laster; P Ionescu; Edmond I Eger; Diane Gong; Richard B Weiskopf
Dehydration of Baralyme increases compound A resulting from sevoflurane degradation in a standard anesthetic circuit used to anesthetize swine.
Anesthesia and analgesia 1997;85(6):1382-6.
1997: F Tayefeh; Merlin D Larson; Daniel Sessler; Edmond I Eger; T Bowland
Time-dependent changes in heart rate and pupil size during desflurane or sevoflurane anesthesia.
Anesthesia and analgesia 1997;85(6):1362-6.
1997: Edmond I Eger; P Ionescu; Michael J Laster; Diane Gong; Richard B Weiskopf; RL Kerschmann
Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane.
Anesthesia and analgesia 1997;85(5):1164-70.
1997: Edmond I Eger; Diane Gong; DD Koblin; T Bowland; P Ionescu; Michael J Laster; Richard B Weiskopf
Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
Anesthesia and analgesia 1997;85(5):1154-63.
1997: Z Fang; Michael J Laster; P Ionescu; DD Koblin; James M Sonner; Edmond I Eger; MJ Halsey
Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats.
Anesthesia and analgesia 1997;85(5):1149-53.
1997: Edmond I Eger; P Ionescu; Michael J Laster; Richard B Weiskopf
Baralyme dehydration increases and soda lime dehydration decreases the concentration of compound A resulting from sevoflurane degradation in a standard anesthetic circuit.
Anesthesia and analgesia 1997;85(4):892-8.
1997: R Griffiths; P Ionescu; Z Fang; DD Koblin; Edmond I Eger
Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants.
British journal of anaesthesia 1997;79(3):389-91.
1997: Edmond I Eger; T Bowland; P Ionescu; Michael J Laster; Z Fang; Diane Gong; James M Sonner; Richard B Weiskopf
Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products.
Anesthesiology 1997;87(3):517-26.
1997: Edmond I Eger; DD Koblin; Michael J Laster; Volker Schurig; Markus Juza; P Ionescu; Diane Gong
Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally.
Anesthesia and analgesia 1997;85(1):188-92.
1997: Z Fang; P Ionescu; Diane Gong; Joan J Kendig; A Harris; Edmond I Eger
Maturation decreases ethanol minimum alveolar anesthetic concentration in mice as previously demonstrated in rats: there is no species difference.
Anesthesia and analgesia 1997;85(1):160-3.
1997: Z Fang; P Ionescu; B S Chortkoff; L Kandel; James M Sonner; Michael J Laster; Edmond I Eger
Anesthetic potencies of n-alkanols: results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics.
Anesthesia and analgesia 1997;84(5):1042-8.
1997: Edmond I Eger; Michael J Laster; R Winegar; C Han; Diane Gong
compound A induces sister chromatid exchanges in Chinese hamster ovary cells.
Anesthesiology 1997;86(4):918-22.
1997: Edmond I Eger; DD Koblin; R Adron Harris; Joan J Kendig; A Pohorille; MJ Halsey; James R Trudell
Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites.
Anesthesia and analgesia 1997;84(4):915-8.
1997: Z Fang; Diane Gong; P Ionescu; Michael J Laster; Edmond I Eger; Joan J Kendig
Maturation decreases ethanol minimum alveolar anesthetic concentration (MAC) more than desflurane MAC in rats.
Anesthesia and analgesia 1997;84(4):852-8.
1997: Z Fang; Michael J Laster; Diane Gong; P Ionescu; DD Koblin; James M Sonner; Edmond I Eger; MJ Halsey
Convulsant activity of nonanesthetic gas combinations.
Anesthesia and analgesia 1997;84(3):634-40.
1997: Dolores B Njoku; Michael J Laster; Diane H Gong; Edmond I Eger; G F Reed; Jackie L Martin
Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury.
Anesthesia and analgesia 1997;84(1):173-8.
1997: Michael J Laster; Diane Gong; RL Kerschmann; Edmond I Eger; Jackie L Martin
Acetaminophen predisposes to renal and hepatic injury from compound A in the fasting rat.
Anesthesia and analgesia 1997;84(1):169-72.
1997: Edmond I Eger; DD Koblin; T Bowland; P Ionescu; Michael J Laster; Z Fang; Diane Gong; James M Sonner; Richard B Weiskopf
Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers.
Anesthesia and analgesia 1997;84(1):160-8.
1996: Z Fang; James M Sonner; Michael J Laster; P Ionescu; L Kandel; DD Koblin; Edmond I Eger; MJ Halsey
Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis.
Anesthesia and analgesia 1996;83(5):1097-104.
1996: Edmond I Eger; P Ionescu; DD Koblin; Richard B Weiskopf
Compound A: solubility in saline and olive oil; destruction by blood.
Anesthesia and analgesia 1996;83(4):849-53.
1996: Z X Fang; L Kandel; Michael J Laster; P Ionescu; Edmond I Eger
Factors affecting production of compound A from the interaction of sevoflurane with Baralyme and soda lime.
Anesthesia and analgesia 1996;82(4):775-81.
1996: Jackie L Martin; Michael J Laster; L Kandel; RL Kerschmann; G F Reed; Edmond I Eger
Metabolism of compound A by renal cysteine-S-conjugate beta-lyase is not the mechanism of compound A-induced renal injury in the rat.
Anesthesia and analgesia 1996;82(4):770-4.
1996: L Kandel; B S Chortkoff; James M Sonner; Michael J Laster; Edmond I Eger
Nonanesthetics can suppress learning.
Anesthesia and analgesia 1996;82(2):321-6.
1996: M Daniel; Edmond I Eger; Richard B Weiskopf; M Noorani
Propofol fails to attenuate the cardiovascular response to rapid increases in desflurane concentration.
Anesthesiology 1996;84(1):75-80.
1995: Richard B Weiskopf; Edmond I Eger; M Daniel; M Noorani
Cardiovascular stimulation induced by rapid increases in desflurane concentration in humans results from activation of tracheopulmonary and systemic receptors.
Anesthesiology 1995;83(6):1173-8.
1995: B S Chortkoff; Edmond I Eger; D P Crankshaw; C T Gonsowski; Robert C Dutton; P Ionescu
Concentrations of desflurane and propofol that suppress response to command in humans.
Anesthesia and analgesia 1995;81(4):737-43.
1995: B S Chortkoff; C T Gonsowski; H L Bennett; Barbara Levinson; D P Crankshaw; Robert C Dutton; P Ionescu; R I Block; Edmond I Eger
Subanesthetic concentrations of desflurane and propofol suppress recall of emotionally charged information.
Anesthesia and analgesia 1995;81(4):728-36.
1995: Edmond I Eger
Economic analysis and pharmaceutical policy: a consideration of the economics of the use of desflurane.
Anaesthesia 1995;50 Suppl():45-8.
1995: Edmond I Eger
Physicochemical properties and pharmacodynamics of desflurane.
Anaesthesia 1995;50 Suppl():3-8.
1995: Z X Fang; Edmond I Eger
Factors affecting the concentration of compound A resulting from the degradation of sevoflurane by soda lime and Baralyme in a standard anesthetic circuit.
Anesthesia and analgesia 1995;81(3):564-8.
1995: L Kandel; Michael J Laster; Edmond I Eger; RL Kerschmann; Jackie L Martin
Nephrotoxicity in rats undergoing a one-hour exposure to compound A.
Anesthesia and analgesia 1995;81(3):559-63.
1995: M Daniel; Merlin D Larson; Edmond I Eger; M Noorani; Richard B Weiskopf
Fentanyl, clonidine, and repeated increases in desflurane concentration, but not nitrous oxide or esmolol, block the transient mydriasis caused by rapid increases in desflurane concentration.
Anesthesia and analgesia 1995;81(2):372-8.
1995: Z X Fang; Edmond I Eger; Michael J Laster; B S Chortkoff; L Kandel; P Ionescu
Carbon monoxide production from degradation of desflurane, enflurane, isoflurane, halothane, and sevoflurane by soda lime and Baralyme.
Anesthesia and analgesia 1995;80(6):1187-93.
1995: C T Gonsowski; B S Chortkoff; Edmond I Eger; H L Bennett; Richard B Weiskopf
Subanesthetic concentrations of desflurane and isoflurane suppress explicit and implicit learning.
Anesthesia and analgesia 1995;80(3):568-72.
1995: Edmond I Eger
New drugs in anesthesia.
International anesthesiology clinics 1995;33(1):61-80.
1994: Richard B Weiskopf; Edmond I Eger; M Noorani; M Daniel
Fentanyl, esmolol, and clonidine blunt the transient cardiovascular stimulation induced by desflurane in humans.
Anesthesiology 1994;81(6):1350-5.
1994: P Ionescu; Edmond I Eger; James R Trudell
Direct determination of oil/saline partition coefficients.
Anesthesia and analgesia 1994;79(6):1056-8.
1994: J Liu; Michael J Laster; S Taheri; Edmond I Eger; B Chortkoff; MJ Halsey
Effect of n-alkane kinetics in rats on potency estimations and the Meyer-Overton hypothesis.
Anesthesia and analgesia 1994;79(6):1049-55.
1994: DD Koblin; B S Chortkoff; Michael J Laster; Edmond I Eger; MJ Halsey; P Ionescu
Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis.
Anesthesia and analgesia 1994;79(6):1043-8.
1994: Richard B Weiskopf; Edmond I Eger; M Noorani; M Daniel
Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulation in humans.
Anesthesiology 1994;81(4):843-9.
1994: C T Gonsowski; Edmond I Eger
Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported.
Anesthesia and analgesia 1994;79(4):710-2.
1994: R C Dwyer; Ira J Rampil; Edmond I Eger; H L Bennett
The electroencephalogram does not predict depth of isoflurane anesthesia.
Anesthesiology 1994;81(2):403-9.
1994: Edmond I Eger; J Liu; DD Koblin; Michael J Laster; S Taheri; MJ Halsey; P Ionescu; B S Chortkoff; T Hudlicky
Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes.
Anesthesia and analgesia 1994;79(2):245-51.
1994: J Liu; Michael J Laster; DD Koblin; Edmond I Eger; MJ Halsey; S Taheri; B Chortkoff
A cutoff in potency exists in the perfluoroalkanes.
Anesthesia and analgesia 1994;79(2):238-44.
1994: B S Chortkoff; Michael J Laster; DD Koblin; S Taheri; Edmond I Eger; MJ Halsey
Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane.
Anesthesia and analgesia 1994;79(2):234-7.
1994: M A Moore; Richard B Weiskopf; Edmond I Eger; M Noorani; L McKay; M Damask
Rapid 1% increases of end-tidal desflurane concentration to greater than 5% transiently increase heart rate and blood pressure in humans.
Anesthesiology 1994;81(1):94-8.
1994: J Katz; J Magee; B Baker; Edmond I Eger
Hepatic necrosis associated with herpesvirus after anesthesia with desflurane and nitrous oxide.
Anesthesia and analgesia 1994;78(6):1173-6.
1994: Michael J Laster; Z Fang; Edmond I Eger
Specific gravities of desflurane, enflurane, halothane, isoflurane, and sevoflurane.
Anesthesia and analgesia 1994;78(6):1152-3.
1994: Richard B Weiskopf; M A Moore; Edmond I Eger; M Noorani; L McKay; B Chortkoff; P S Hart; M Damask
Rapid increase in desflurane concentration is associated with greater transient cardiovascular stimulation than with rapid increase in isoflurane concentration in humans.
Anesthesiology 1994;80(5):1035-45.
1994: Edmond I Eger
New inhaled anesthetics.
Anesthesiology 1994;80(4):906-22.
1994: C T Gonsowski; Michael J Laster; Edmond I Eger; L D Ferrell; RL Kerschmann
Toxicity of compound A in rats. Effect of a 3-hour administration.
Anesthesiology 1994;80(3):556-65.
1994: C T Gonsowski; Michael J Laster; Edmond I Eger; L D Ferrell; RL Kerschmann
Toxicity of compound A in rats. Effect of increasing duration of administration.
Anesthesiology 1994;80(3):566-73.
1994: R Navarro; Richard B Weiskopf; M A Moore; S Lockhart; Edmond I Eger; DD Koblin; G Lu; C Wilson
Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine.
Anesthesiology 1994;80(3):545-9.
1994: David P Strum; Edmond I Eger
The degradation, absorption, and solubility of volatile anesthetics in soda lime depend on water content.
Anesthesia and analgesia 1994;78(2):340-8.
1993: Richard B Weiskopf; Edmond I Eger
Comparing the costs of inhaled anesthetics.
Anesthesiology 1993;79(6):1413-8.
1993: M A Moore; Richard B Weiskopf; Edmond I Eger; C Wilson; G Lu
Arrhythmogenic doses of epinephrine are similar during desflurane or isoflurane anesthesia in humans.
Anesthesiology 1993;79(5):943-7.
1993: B S Chortkoff; H L Bennett; Edmond I Eger
Does nitrous oxide antagonize isoflurane-induced suppression of learning?
Anesthesiology 1993;79(4):724-32.
1993: Edmond I Eger
The clinical use of desflurane.
The Yale journal of biology and medicine 1993;66(5):491-500.
1993: B S Chortkoff; H L Bennett; Edmond I Eger
Subanesthetic concentrations of isoflurane suppress learning as defined by the category-example task.
Anesthesiology 1993;79(1):16-22.
1993: S Taheri; Michael J Laster; J Liu; Edmond I Eger; MJ Halsey; DD Koblin
Anesthesia by n-alkanes not consistent with the Meyer-Overton hypothesis: determinations of the solubilities of alkanes in saline and various lipids.
Anesthesia and analgesia 1993;77(1):7-11.
1993: J Liu; Michael J Laster; S Taheri; Edmond I Eger; DD Koblin; MJ Halsey
Is there a cutoff in anesthetic potency for the normal alkanes?
Anesthesia and analgesia 1993;77(1):12-8.
1993: Michael J Laster; J Liu; Edmond I Eger; S Taheri
Electrical stimulation as a substitute for the tail clamp in the determination of minimum alveolar concentration.
Anesthesia and analgesia 1993;76(6):1310-2.
1993: Edmond I Eger
New inhalational agents--desflurane and sevoflurane.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1993;40(5 Pt 2):R3-8.
1992: R Dwyer; H L Bennett; Edmond I Eger; D Heilbron
Effects of isoflurane and nitrous oxide in subanesthetic concentrations on memory and responsiveness in volunteers.
Anesthesiology 1992;77(5):888-98.
1992: Edmond I Eger
Desflurane animal and human pharmacology: aspects of kinetics, safety, and MAC.
Anesthesia and analgesia 1992;75(4 Suppl):S3-7; discussion S8-9.
1992: Michael K Cahalan; Y Hashimoto; K Aizawa; D Verotta; P Ionescu; Michel C Balea; Edmond I Eger; Leslie Z Benet; W K Ehrenfeld; J Goldstone
Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.
Anesthesiology 1992;77(4):646-55.
1992: R Dwyer; H L Bennett; Edmond I Eger; N Peterson
Isoflurane anesthesia prevents unconscious learning.
Anesthesia and analgesia 1992;75(1):107-12.
1992: Richard B Weiskopf; Edmond I Eger; P Ionescu; N Yasuda; Michael K Cahalan; B Freire; N Peterson; S H Lockhart; Ira J Rampil; Michael J Laster
Desflurane does not produce hepatic or renal injury in human volunteers.
Anesthesia and analgesia 1992;74(4):570-4.
1991: David P Strum; Edmond I Eger; J D Unadkat; B H Johnson; R L Carpenter
Age affects the pharmacokinetics of inhaled anesthetics in humans.
Anesthesia and analgesia 1991;73(3):310-8.
1991: Michael J Laster; S Taheri; Edmond I Eger; J Liu; Ira J Rampil; R Dwyer
Visceral losses of desflurane, isoflurane, and halothane in swine.
Anesthesia and analgesia 1991;73(2):209-12.
1991: T S Sutton; DD Koblin; L D Gruenke; Richard B Weiskopf; Ira J Rampil; Lucy Waskell; Edmond I Eger
Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane.
Anesthesia and analgesia 1991;73(2):180-5.
1991: N Yasuda; Richard B Weiskopf; Michael K Cahalan; P Ionescu; James E Caldwell; Edmond I Eger; Ira J Rampil; S H Lockhart
Does desflurane modify circulatory responses to stimulation in humans?
Anesthesia and analgesia 1991;73(2):175-9.
1991: Richard B Weiskopf; Michael K Cahalan; P Ionescu; Edmond I Eger; N Yasuda; S H Lockhart; Ira J Rampil; Michael J Laster; B Freire; N Peterson
Cardiovascular actions of desflurane with and without nitrous oxide during spontaneous ventilation in humans.
Anesthesia and analgesia 1991;73(2):165-74.
1991: Michael K Cahalan; Richard B Weiskopf; Edmond I Eger; N Yasuda; P Ionescu; Ira J Rampil; S H Lockhart; B Freire; N A Peterson
Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers.
Anesthesia and analgesia 1991;73(2):157-64.
1991: Richard B Weiskopf; Michael K Cahalan; Edmond I Eger; N Yasuda; Ira J Rampil; P Ionescu; S H Lockhart; B H Johnson; B Freire; S Kelley
Cardiovascular actions of desflurane in normocarbic volunteers.
Anesthesia and analgesia 1991;73(2):143-56.
1991: J Liu; Michael J Laster; Edmond I Eger; S Taheri
Absorption and degradation of sevoflurane and isoflurane in a conventional anesthetic circuit.
Anesthesia and analgesia 1991;72(6):785-9.
1991: Ira J Rampil; Michael J Laster; R C Dwyer; S Taheri; Edmond I Eger
No EEG evidence of acute tolerance to desflurane in swine.
Anesthesiology 1991;74(5):889-92.
1991: S Taheri; MJ Halsey; J Liu; Edmond I Eger; DD Koblin; Michael J Laster
What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?
Anesthesia and analgesia 1991;72(5):627-34.
1991: S H Lockhart; Y Cohen; N Yasuda; B Freire; S Taheri; Lawrence Litt; Edmond I Eger
Cerebral uptake and elimination of desflurane, isoflurane, and halothane from rabbit brain: an in vivo NMR study.
Anesthesiology 1991;74(3):575-80.
1991: N Yasuda; S H Lockhart; Edmond I Eger; Richard B Weiskopf; B H Johnson; B A Freire; Argyro Fassoulaki
Kinetics of desflurane, isoflurane, and halothane in humans.
Anesthesiology 1991;74(3):489-98.
1991: Argyro Fassoulaki; S H Lockhart; B A Freire; N Yasuda; Edmond I Eger; Richard B Weiskopf; B H Johnson
Percutaneous loss of desflurane, isoflurane, and halothane in humans.
Anesthesiology 1991;74(3):479-83.
1991: Ira J Rampil; S H Lockhart; Edmond I Eger; N Yasuda; Richard B Weiskopf; Michael K Cahalan
The electroencephalographic effects of desflurane in humans.
Anesthesiology 1991;74(3):434-9.
1991: Ira J Rampil; S H Lockhart; Maurice S Zwass; N Peterson; N Yasuda; Edmond I Eger; Richard B Weiskopf; M C Damask
Clinical characteristics of desflurane in surgical patients: minimum alveolar concentration.
Anesthesiology 1991;74(3):429-33.
1991: James E Caldwell; Michael J Laster; T Magorian; T Heier; N Yasuda; D P Lynam; Edmond I Eger; Richard B Weiskopf
The neuromuscular effects of desflurane, alone and combined with pancuronium or succinylcholine in humans.
Anesthesiology 1991;74(3):412-8.
1991: N Yasuda; S H Lockhart; Edmond I Eger; Richard B Weiskopf; J Liu; Michael J Laster; S Taheri; N A Peterson
Comparison of kinetics of sevoflurane and isoflurane in humans.
Anesthesia and analgesia 1991;72(3):316-24.
1991: S H Lockhart; Ira J Rampil; N Yasuda; Edmond I Eger; Richard B Weiskopf
Depression of ventilation by desflurane in humans.
Anesthesiology 1991;74(3):484-8.
1991: S H Lockhart; N Yasuda; N Peterson; Michael J Laster; S Taheri; Richard B Weiskopf; Edmond I Eger
Comparison of percutaneous losses of sevoflurane and isoflurane in humans.
Anesthesia and analgesia 1991;72(2):212-5.
1990: F M Waldman; DD Koblin; G H Lampe; L Z Wauk; Edmond I Eger
Hematologic effects of nitrous oxide in surgical patients.
Anesthesia and analgesia 1990;71(6):618-24.
1990: DD Koblin; B W Tomerson; F M Waldman; G H Lampe; L Z Wauk; Edmond I Eger
Effect of nitrous oxide on folate and vitamin B12 metabolism in patients.
Anesthesia and analgesia 1990;71(6):610-7.
1990: G H Lampe; L Z Wauk; P Whitendale; W L Way; W Murray; Edmond I Eger
Nitrous oxide does not impair hepatic function in young or old surgical patients.
Anesthesia and analgesia 1990;71(6):606-9.
1990: G H Lampe; L Z Wauk; P Whitendale; W L Way; S V Kozmary; J H Donegan; Edmond I Eger
Postoperative hypoxemia after nonabdominal surgery: a frequent event not caused by nitrous oxide.
Anesthesia and analgesia 1990;71(6):597-601.
1990: S V Kozmary; G H Lampe; D Benefiel; Michael K Cahalan; L Z Wauk; P Whitendale; Nelson B Schiller; Edmond I Eger
No finding of increased myocardial ischemia during or after carotid endarterectomy under anesthesia with nitrous oxide.
Anesthesia and analgesia 1990;71(6):591-6.
1990: G H Lampe; L Z Wauk; J H Donegan; L H Pitts; R K Jackler; Lawrence Litt; Ira J Rampil; Edmond I Eger
Effect on outcome of prolonged exposure of patients to nitrous oxide.
Anesthesia and analgesia 1990;71(6):586-90.
1990: Edmond I Eger; G H Lampe; L Z Wauk; P Whitendale; Michael K Cahalan; J H Donegan
Clinical pharmacology of nitrous oxide: an argument for its continued use.
Anesthesia and analgesia 1990;71(6):575-85.
1990: N Yasuda; A G Targ; Edmond I Eger; B H Johnson; Richard B Weiskopf
Pharmacokinetics of desflurane, sevoflurane, isoflurane, and halothane in pigs.
Anesthesia and analgesia 1990;71(4):340-8.
1990: S H Lockhart; Y Cohen; N Yasuda; F Kim; Lawrence Litt; Edmond I Eger; L H Chang; Tom L James
Absence of abundant binding sites for anesthetics in rabbit brain: an in vivo NMR study.
Anesthesiology 1990;73(3):455-60.
1990: M A Holmes; Richard B Weiskopf; Edmond I Eger; B H Johnson; Ira J Rampil
Hepatocellular integrity in swine after prolonged desflurane (I-653) and isoflurane anesthesia: evaluation of plasma alanine aminotransferase activity.
Anesthesia and analgesia 1990;71(3):249-53.
1990: Richard B Weiskopf; Edmond I Eger; M A Holmes; N Yasuda; B H Johnson; A G Targ; Ira J Rampil
Cardiovascular actions of common anesthetic adjuvants during desflurane (I-653) and isoflurane anesthesia in swine.
Anesthesia and analgesia 1990;71(2):144-8.
1990: S H Lockhart; Edmond I Eger
Absence of abundant saturable binding sites for halothane or isoflurane in rabbit brain: inhaled anesthetics obey Henry's law.
Anesthesia and analgesia 1990;71(1):70-2.
1990: Michael J Laster; B H Johnson; Edmond I Eger; S Taheri
A method for testing for epinephrine-induced arrhythmias in rats.
Anesthesia and analgesia 1990;70(6):654-7.
1990: Argyro Fassoulaki; Kenneth Drasner; Edmond I Eger
Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat?
Anesthesia and analgesia 1990;70(5):489-92.
1990: Edmond I Eger
A template for writing a scientific paper.
Anesthesia and analgesia 1990;70(1):91-6.
1989: N A Nussmeier; M L Lambert; G J Moskowitz; N H Cohen; Richard B Weiskopf; Dennis M Fisher; Edmond I Eger
Washin and washout of isoflurane administered via bubble oxygenators during hypothermic cardiopulmonary bypass.
Anesthesiology 1989;71(4):519-25.
1989: N Yasuda; A G Targ; Edmond I Eger
Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.
Anesthesia and analgesia 1989;69(3):370-3.
1989: I S Gauntlett; DD Koblin; M R Fahey; K Konopka; L D Gruenke; Lucy Waskell; Edmond I Eger
Metabolism of isoflurane in patients receiving isoniazid.
Anesthesia and analgesia 1989;69(2):245-9.
1989: A G Targ; N Yasuda; Edmond I Eger
Solubility of I-653, sevoflurane, isoflurane, and halothane in plastics and rubber composing a conventional anesthetic circuit.
Anesthesia and analgesia 1989;69(2):218-25.
1989: Edmond I Eger
A glossary of anesthetic jargon.
Anesthesia and analgesia 1989;68(6):740-3.
1989: Richard B Weiskopf; M A Holmes; Ira J Rampil; B H Johnson; N Yasuda; A G Targ; Edmond I Eger
Cardiovascular safety and actions of high concentrations of I-653 and isoflurane in swine.
Anesthesiology 1989;70(5):793-8.
1989: A G Targ; N Yasuda; Edmond I Eger; G Huang; G G Vernice; R C Terrell; DD Koblin
Halogenation and anesthetic potency.
Anesthesia and analgesia 1989;68(5):599-602.
1989: R L Carpenter; Edmond I Eger
Alveolar-to-arterial-to-venous anesthetic partial pressure differences in humans.
Anesthesiology 1989;70(4):630-5.
1989: DD Koblin; Richard B Weiskopf; M A Holmes; K Konopka; Ira J Rampil; Edmond I Eger; Lucy Waskell
Metabolism of I-653 and isoflurane in swine.
Anesthesia and analgesia 1989;68(2):147-9.
1989: Richard B Weiskopf; Edmond I Eger; M A Holmes; Ira J Rampil; B Johnson; J G Brown; N Yasuda; A G Targ
Epinephrine-induced premature ventricular contractions and changes in arterial blood pressure and heart rate during I-653, isoflurane, and halothane anesthesia in swine.
Anesthesiology 1989;70(2):293-8.
1988: Edmond I Eger; B H Johnson; Richard B Weiskopf; M A Holmes; N Yasuda; A Targ; Ira J Rampil
Minimum alveolar concentration of I-653 and isoflurane in pigs: definition of a supramaximal stimulus.
Anesthesia and analgesia 1988;67(12):1174-6.
1988: N A Nussmeier; G J Moskowitz; Richard B Weiskopf; N H Cohen; Dennis M Fisher; Edmond I Eger
In vitro anesthetic washin and washout via bubble oxygenators: influence of anesthetic solubility and rates of carrier gas inflow and pump blood flow.
Anesthesia and analgesia 1988;67(10):982-7.
1988: Richard B Weiskopf; M A Holmes; Edmond I Eger; B H Johnson; Ira J Rampil; J G Brown
Cardiovascular effects of I653 in swine.
Anesthesiology 1988;69(3):303-9.
1988: Ira J Rampil; Richard B Weiskopf; J G Brown; Edmond I Eger; B H Johnson; M A Holmes; J H Donegan
I653 and isoflurane produce similar dose-related changes in the electroencephalogram of pigs.
Anesthesiology 1988;69(3):298-302.
1988: DD Koblin; Edmond I Eger; B H Johnson; K Konopka; Lucy Waskell
I-653 resists degradation in rats.
Anesthesia and analgesia 1988;67(6):534-8.
1987: Edmond I Eger; D P Strum
The absorption and degradation of isoflurane and I-653 by dry soda lime at various temperatures.
Anesthesia and analgesia 1987;66(12):1312-5.
1987: Edmond I Eger; B H Johnson; L D Ferrell
Comparison of the toxicity of I-653 and isoflurane in rats: a test of the effect of repeated anesthesia and use of dry soda lime.
Anesthesia and analgesia 1987;66(12):1230-3.
1987: Edmond I Eger; B H Johnson; D P Strum; L D Ferrell
Studies of the toxicity of I-653, halothane, and isoflurane in enzyme-induced, hypoxic rats.
Anesthesia and analgesia 1987;66(12):1227-9.
1987: D P Strum; B H Johnson; Edmond I Eger
Stability of sevoflurane in soda lime.
Anesthesiology 1987;67(5):779-81.
1981: DD Koblin; Edmond I Eger; B H Johnson; P Collins; R C Terrell; L Speers
Are convulsant gases also anesthetics?
Anesthesia and analgesia 1981;60(7):464-70.
1981: DD Koblin; Edmond I Eger; B H Johnson; P Collins; M H Harper; R C Terrell; L Speers
Minimum alveolar concentrations and oil/gas partition coefficients of four anesthetic isomers.
Anesthesiology 1981;54(4):314-7.