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Ute Egerland

Research Profile

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Michael S Malamas; Karen L Marquis; Rachel Navarra; Yike Ni; Menelas N Pangalos; Kevin Parris; Albert J Robichaud; Rudolf Schindler; Hans Stange; Nicholas J Brandon; Julie Brennan; Ute Egerland; James Erdei; Kristi Yi Fan; Radka Graf; Steve Grauer; Christian Grunwald; Thorsten Hage; Boyd L Harrison; Thomas Kronbach; Barbara Langen; Hans-Joachim Lankau; Norbert Hoefgen
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Barbara Langen; Hans Stange; Rita Dost; Ute Egerland; Norbert Hoefgen
Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.
Rainer Gewald; Christian Grunwald; Ute Egerland; Carla Rueger; Norbert Hoefgen
Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.

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All Publications

2012: Michael S Malamas; Karen L Marquis; Rachel Navarra; Yike Ni; Menelas N Pangalos; Kevin Parris; Albert J Robichaud; Rudolf Schindler; Hans Stange; Nicholas J Brandon; Julie Brennan; Ute Egerland; James Erdei; Kristi Yi Fan; Radka Graf; Steve Grauer; Christian Grunwald; Thorsten Hage; Boyd L Harrison; Thomas Kronbach; Barbara Langen; Hans-Joachim Lankau; Norbert Hoefgen
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(18):5876-84.
2012: Barbara Langen; Hans Stange; Rita Dost; Ute Egerland; Norbert Hoefgen
Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test.
Psychopharmacology 2012;221(2):249-59.
2011: Rainer Gewald; Christian Grunwald; Ute Egerland; Carla Rueger; Norbert Hoefgen
Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(22):6652-6.
2011: Michael S Malamas; Karen L Marquis; Rachel Navarra; Yike Ni; Menelas N Pangalos; Kevin Parris; Albert J Robichaud; Rudolf Schindler; Hans Stange; Julie Brennan; Ute Egerland; James Erdei; Kristi Yi Fan; Radka Graf; Steve Grauer; Christian Grunwald; Thorsten Hage; Boyd L Harrison; Norbert Hoefgen; Thomas Kronbach; Barbara Langen; Hans-Joachim Lankau; Nicholas J Brandon
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.
Journal of medicinal chemistry 2011;54(21):7621-38.
2010: Norbert Höfgen; Hans Stange; Rudolf Schindler; Hans-Joachim Lankau; Christian Grunwald; Barbara Langen; Ute Egerland; Peter Tremmel; Menelas N Pangalos; Karen L Marquis; Thorsten Hage; Boyd L Harrison; Michael S Malamas; Nicholas J Brandon; Thomas Kronbach
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Journal of medicinal chemistry 2010;53(11):4399-411.
2009: Steven M Grauer; Virginia L Pulito; Rachel L Navarra; Michele P Kelly; Cody Kelley; Radka Graf; Barbara Langen; Sheree Logue; Julie Brennan; Lixin Jiang; Erik Charych; Ute Egerland; Feng Liu; Karen L Marquis; Michael Malamas; Thorsten Hage; thomas Comery; Nicholas J Brandon
Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia.
The Journal of pharmacology and experimental therapeutics 2009;331(2):574-90.
2007: Hans-Joachim Lankau; Klaus Unverferth; Christian Grunwald; Helge Hartenhauer; Kristina Heinecke; Katrin Bernöster; Rita Dost; Ute Egerland; Chris Rundfeldt
New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity.
European journal of medicinal chemistry 2007;42(6):873-9.
2006: Christian Grunwald; Chris Rundfeldt; Hans-Joachim Lankau; Thomas Arnold; Norbert Höfgen; Rita Dost; Ute Egerland; Hans-Jörg Hofmann; Klaus Unverferth
Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Journal of medicinal chemistry 2006;49(6):1855-66.
2005: Detlef Briel; R Aurich; Ute Egerland; Klaus Unverferth
[Synthesis of substituted 6-phenylpyrazolo[3,4-d]pyrimidines with potential adenosin-A2A antagonistic activity].
Die Pharmazie 2005;60(10):732-5.
2005: Barbara Langen; Ute Egerland; Katrin Bernöster; Rita Dost; Klaus Unverferth; Chris Rundfeldt
Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor.
The Journal of pharmacology and experimental therapeutics 2005;314(2):717-24.
2004: Susanne Ullmann; Thorsten Hage; Regina Draheim; Ute Egerland; Uwe Oelmüller; Kay Brune; Andreas Pahl
RNA-based drug screening using automated RNA purification and real-time RT-PCR1.
Journal of biomolecular screening 2004;9(2):95-102.
2004: Regina Draheim; Ute Egerland; Chris Rundfeldt
Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations.
The Journal of pharmacology and experimental therapeutics 2004;308(2):555-63.
2000: Wito Richter; Thomas Hermsdorf; H Lilie; Ute Egerland; R Rudolph; Thomas Kronbach; Dietrich Dettmer
Refolding, purification, and characterization of human recombinant PDE4A constructs expressed in Escherichia coli.
Protein expression and purification 2000;19(3):375-83.
1998: R Schindler; I Fleischhauer; Norbert Höfgen; W Sauer; Ute Egerland; H Poppe; Sabine Heer; Istvan Szelenyi; B Kutscher; J Engel
1,5-Disubstituted indazol-3-ols with anti-inflammatory activity.
Archiv der Pharmazie 1998;331(1):13-21.
1997: H Poppe; NV Kaverina; V V Lyskovzev; Ute Egerland; W Sauer; A Lichoscherstow; C Rüger; A Skoldinow
New 5-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones with antiarrhythmic activity.
Die Pharmazie 1997;52(11):821-30.