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Martin Egli

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Rekha Pattanayek; Kirthi Kiran Yadagiri; Melanie D Ohi; Martin Egli
Nature of KaiB-KaiC binding in the cyanobacterial circadian oscillator.
Martin Egli; Tetsuya Mori; Rekha Pattanayek; Jonathan Holden Sheehan; Jarrod A Smith; Yao Xu; Carl H Johnson
Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.
Amritraj Patra; Linlin Zhao; Mikhail Abramov; Joel Harp; Piet Herdewijn; Pradeep S Pallan; Martin Egli
Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.

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All Publications

2013: Rekha Pattanayek; Kirthi Kiran Yadagiri; Melanie D Ohi; Martin Egli
Nature of KaiB-KaiC binding in the cyanobacterial circadian oscillator.
Cell cycle (Georgetown, Tex.) 2013;12(5):810-7.
2013: Martin Egli; Tetsuya Mori; Rekha Pattanayek; Jonathan Holden Sheehan; Jarrod A Smith; Yao Xu; Carl H Johnson
Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.
Biochemistry 2013;52(7):1208-20.
2013: Amritraj Patra; Linlin Zhao; Mikhail Abramov; Joel Harp; Piet Herdewijn; Pradeep S Pallan; Martin Egli
Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic acids research 2013;41(4):2689-97.
2013: Punit P Seth; Eric E Swayze; Pradeep S Pallan; Martin Egli
Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue.
Chembiochem : a European journal of chemical biology 2013;14(1):58-62.
2012: Amritraj Patra; Eriks Rozners; Klaus Charisse; Muthiah Manoharan; Michael Paolillo; Martin Egli
2'-Fluoro RNA shows increased Watson-Crick H-bonding strength and stacking relative to RNA: evidence from NMR and thermodynamic data.
Angewandte Chemie (International ed. in English) 2012;51(47):11863-6.
2012: Rekha Pattanayek; Said K Sidiqi; Martin Egli
Crystal structure of the redox-active cofactor dibromothymoquinone bound to circadian clock protein KaiA and structural basis for dibromothymoquinone's ability to prevent stimulation of KaiC phosphorylation by KaiA.
Biochemistry 2012;51(41):8050-2.
2012: Pradeep S Pallan; Thazha P Prakash; Punit P Seth; Eric E Swayze; Charles R Allerson; Andres Berdeja; Martin Egli
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chemical communications (Cambridge, England) 2012;48(66):8195-7.
2012: Martin Egli
The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data.
Accounts of chemical research 2012;45(8):1237-46.
2012: Punit P Seth; Jinghua Yu; Michael E Østergaard; Charles R Allerson; Martin Egli; Piet Herdewijn; Ali Jazayeri; Fengwu Liu; Pradeep S Pallan; Eric E Swayze
Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.
The Journal of organic chemistry 2012;77(11):5074-85.
2012: Linlin Zhao; Plamen P Christov; Martin Egli; Ivan D Kozekov; Pradeep S Pallan; Matthew G Pence; Carmelo J Rizzo; F Peter Guengerich
Replication of N2,3-ethenoguanine by DNA polymerases.
Angewandte Chemie (International ed. in English) 2012;51(22):5466-9.
2012: Pradeep S Pallan; Victor E Marquez; Martin Egli
The conformationally constrained N-methanocarba-dT analogue adopts an unexpected C4'-exo sugar pucker in the structure of a DNA hairpin.
Biochemistry 2012;51(13):2639-41.
2012: Martin Egli; Tetsuya Mori; Rekha Pattanayek; Ximing Qin; Yao Xu; Carl H Johnson
Dephosphorylation of the core clock protein KaiC in the cyanobacterial KaiABC circadian oscillator proceeds via an ATP synthase mechanism.
Biochemistry 2012;51(8):1547-58.
2012: Surajit Banerjee; Plamen P Christov; Martin Egli; Albena Kozekova; Carmelo J Rizzo; Michael P Stone
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV.
Chemical research in toxicology 2012;25(2):422-35.
2011: Ewa A Kowal; Luis A Marky; Pradeep S Pallan; Martin Egli; Manjori Ganguly; Barry Gold; Michael P Stone
Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA.
The journal of physical chemistry. B 2011;115(47):13925-34.
2011: Martin Egli; Hans Gaus; Sam Lee; Pradeep S Pallan; Thazha P Prakash; Charles R Allerson; Andres Berdeja; Balkrishen Bhat; Eric E Swayze; Andrew Watt; Jinghua Yu; Punit P Seth
Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
Journal of the American Chemical Society 2011;133(41):16642-9.
2011: Surajit Banerjee; Kyle L Brown; Martin Egli; Michael P Stone
Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV.
Journal of the American Chemical Society 2011;133(32):12556-68.
2011: Pradeep S Pallan; Emily M Greene; Paul Andrei Jicman; Rajendra K Pandey; Muthiah Manoharan; Eriks Rozners; Martin Egli
Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic acids research 2011;39(8):3482-95.
2011: Muthiah Manoharan; Akin Akinc; Rajendra K Pandey; June Qin; Philipp Hadwiger; Matthias John; Kathy Mills; Klaus Charisse; Martin A Maier; Lubomir Nechev; Emily M Greene; Pradeep S Pallan; Eriks Rozners; Kallanthottathil G Rajeev; Martin Egli
Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.
Angewandte Chemie (International ed. in English) 2011;50(10):2284-8.
2011: Rekha Pattanayek; Gian Rossi; Phoebe L Stewart; Steven Weigand; Dewight R Williams; Carl Hirschie Johnson; Tetsuya Mori; Martin Egli
Combined SAXS/EM based models of the S. elongatus post-translational circadian oscillator and its interactions with the output His-kinase SasA.
PloS one 2011;6(8):e23697.
2011: Carl Hirschie Johnson; Phoebe L Stewart; Martin Egli
The cyanobacterial circadian system: from biophysics to bioevolution.
Annual review of biophysics 2011;40():143-67.
2010: Matthew G Pence; Jeong-Yun Choi; Martin Egli; F Peter Guengerich
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.
The Journal of biological chemistry 2010;285(52):40666-72.
2010: Punit P Seth; Charles R Allerson; Andres Berdeja; Andrew Siwkowski; Pradeep S Pallan; Hans Gaus; Thazha P Prakash; Andrew T Watt; Martin Egli; Eric E Swayze
An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
Journal of the American Chemical Society 2010;132(42):14942-50.
2010: adriana irimia; Lioudmila V Loukachevitch; Robert L Eoff; F Peter Guengerich; Martin Egli
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 9):1013-8.
2010: Martin Egli
Diffraction techniques in structural biology.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2010;Chapter 7():Unit 7.13.
2010: Martin Egli; Pradeep S Pallan
The many twists and turns of DNA: template, telomere, tool, and target.
Current opinion in structural biology 2010;20(3):262-75.
2010: Martin Egli; Pradeep S Pallan
Crystallographic studies of chemically modified nucleic acids: a backward glance.
Chemistry & biodiversity 2010;7(1):60-89.
2009: Andrej Kolarovic; Emma Schweizer; Emily Greene; Mark Gironda; Pradeep S Pallan; Martin Egli; Eriks Rozners
Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
Journal of the American Chemical Society 2009;131(41):14932-7.
2009: Pradeep S Pallan; Martin Egli
Pairing geometry of the hydrophobic thymine analogue 2,4-difluorotoluene in duplex DNA as analyzed by X-ray crystallography.
Journal of the American Chemical Society 2009;131(35):12548-9.
2009: adriana irimia; Robert L Eoff; F Peter Guengerich; Martin Egli
Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct.
The Journal of biological chemistry 2009;284(33):22467-80.
2009: Robert L Eoff; Jennifer B Stafford; Jozsef Szekely; Carmelo J Rizzo; Martin Egli; F Peter Guengerich; Lawrence J Marnett
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.
Biochemistry 2009;48(30):7079-88.
2009: Huidong Zhang; Robert L Eoff; Ivan D Kozekov; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes.
The Journal of biological chemistry 2009;284(26):17687-99.
2009: Pradeep S Pallan; Thazha P Prakash; Feng Li; Robert L Eoff; Muthiah Manoharan; Martin Egli
A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chemical communications (Cambridge, England) 2009;(15):2017-9.
2009: Huidong Zhang; Robert L Eoff; Ivan D Kozekov; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts.
The Journal of biological chemistry 2009;284(6):3563-76.
2009: Rekha Pattanayek; Tetsuya Mori; Yao Xu; Sabuj Pattanayek; Carl Hirschie Johnson; Martin Egli
Structures of KaiC circadian clock mutant proteins: a new phosphorylation site at T426 and mechanisms of kinase, ATPase and phosphatase.
PloS one 2009;4(11):e7529.
2009: Yao Xu; Tetsuya Mori; Ximing Qin; Heping Yan; Martin Egli; Carl Hirschie Johnson
Intramolecular regulation of phosphorylation status of the circadian clock protein KaiC.
PloS one 2009;4(11):e7509.
2008: Carl Hirschie Johnson; Martin Egli; Phoebe L Stewart
Structural insights into a circadian oscillator.
Science (New York, N.Y.) 2008;322(5902):697-701.
2008: Pradeep S Pallan; Christoph Kreutz; Silvia Bosio; Ronald Micura; Martin Egli
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.
RNA (New York, N.Y.) 2008;14(10):2125-35.
2008: Pradeep S Pallan; Martin Egli
Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.
Cell cycle (Georgetown, Tex.) 2008;7(16):2562-9.
2008: Yazhen Wang; Sarah K Musser; Sam Saleh; Lawrence J Marnett; Martin Egli; Michael P Stone
Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV.
Biochemistry 2008;47(28):7322-34.
2008: Feng Wang; Feng Li; Manjori Ganguly; Luis A Marky; Barry Gold; Martin Egli; Michael P Stone
A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.
Biochemistry 2008;47(27):7147-57.
2008: Rekha Pattanayek; Dewight R Williams; Sabuj Pattanayek; Tetsuya Mori; Carl Hirschie Johnson; Phoebe L Stewart; Martin Egli
Structural model of the circadian clock KaiB-KaiC complex and mechanism for modulation of KaiC phosphorylation.
The EMBO journal 2008;27(12):1767-78.
2008: Pradeep S Pallan; Damian Ittig; Annie Héroux; Zdzislaw Wawrzak; Christian J Leumann; Martin Egli
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
Chemical communications (Cambridge, England) 2008;(7):883-5.
2007: adriana irimia; Robert L Eoff; Pradeep S Pallan; F Peter Guengerich; Martin Egli
Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene.
The Journal of biological chemistry 2007;282(50):36421-33.
2007: Robert L Eoff; adriana irimia; Karen C Angel; Martin Egli; F Peter Guengerich
Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4.
The Journal of biological chemistry 2007;282(27):19831-43.
2007: Robert L Eoff; Karen C Angel; Martin Egli; F Peter Guengerich
Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing.
The Journal of biological chemistry 2007;282(18):13573-84.
2007: Pradeep S Pallan; Paolo Lubini; Martin Egli
A left-handed supramolecular assembly around a right-handed screw axis in the crystal structure of homo-DNA.
Chemical communications (Cambridge, England) 2007;(14):1447-9.
2007: Tetsuya Mori; Dewight R Williams; Mark O Byrne; Ximing Qin; Martin Egli; Hassane S McHaourab; Phoebe L Stewart; Carl Hirschie Johnson
Elucidating the ticking of an in vitro circadian clockwork.
PLoS biology 2007;5(4):e93.
2007: Martin Egli; Sanjay Sarkhel
Lone pair-aromatic interactions: to stabilize or not to stabilize.
Accounts of chemical research 2007;40(3):197-205.
2007: Zigmund Luka; Svetlana Pakhomova; Lioudmila V Loukachevitch; Martin Egli; Marcia E Newcomer; Conrad Wagner
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.
The Journal of biological chemistry 2007;282(6):4069-75.
2007: Lioudmila V Loukachevitch; Martin Egli
Crystallization and preliminary X-ray analysis of Escherichia coli RNase HI-dsRNA complexes.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 2):84-8.
2007: Robert L Eoff; adriana irimia; Martin Egli; F Peter Guengerich
Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.
The Journal of biological chemistry 2007;282(2):1456-67.
2007: Pradeep S Pallan; Paolo Lubini; Martin Bolli; Martin Egli
Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing.
Nucleic acids research 2007;35(19):6611-24.
2007: Feng Li; Pradeep S Pallan; Martin A Maier; Kallanthottathil G Rajeev; Steven L Mathieu; Christoph Kreutz; Yupeng Fan; Jayodita Sanghvi; Ronald Micura; Eriks Rozners; Muthiah Manoharan; Martin Egli
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic acids research 2007;35(19):6424-38.
2007: Pradeep S Pallan; Martin Egli
Selenium modification of nucleic acids: preparation of oligonucleotides with incorporated 2'-SeMe-uridine for crystallographic phasing of nucleic acid structures.
Nature protocols 2007;2(3):647-51.
2007: Pradeep S Pallan; Martin Egli
Selenium modification of nucleic acids: preparation of phosphoroselenoate derivatives for crystallographic phasing of nucleic acid structures.
Nature protocols 2007;2(3):640-6.
2007: Martin Egli; Pradeep S Pallan
Insights from crystallographic studies into the structural and pairing properties of nucleic acid analogs and chemically modified DNA and RNA oligonucleotides.
Annual review of biophysics and biomolecular structure 2007;36():281-305.
2007: Martin Egli; Paolo Lubini; Pradeep S Pallan
The long and winding road to the structure of homo-DNA.
Chemical Society reviews 2007;36(1):31-45.
2006: Martin Egli; Pradeep S Pallan; Rekha Pattanayek; Christopher J Wilds; Paolo Lubini; George Minasov; Max Dobler; Christian J Leumann; Albert Eschenmoser
Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system.
Journal of the American Chemical Society 2006;128(33):10847-56.
2006: Pradeep S Pallan; Peter von Matt; Christopher J Wilds; Karl-Heinz Altmann; Martin Egli
RNA-Binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures.
Biochemistry 2006;45(26):8048-57.
2006: adriana irimia; Hong Zang; Lioudmila V Loukachevitch; Robert L Eoff; F Peter Guengerich; Martin Egli
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4.
Biochemistry 2006;45(19):5949-56.
2006: Rekha Pattanayek; Dewight R Williams; Sabuj Pattanayek; Yao Xu; Tetsuya Mori; Carl Hirschie Johnson; Phoebe L Stewart; Martin Egli
Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods.
The EMBO journal 2006;25(9):2017-28.
2006: Jie Xia; Anne Noronha; Ivanka Toudjarska; Feng Li; Akin Akinc; Ravi Braich; Maria Frank-Kamenetsky; Kallanthottathil G Rajeev; Martin Egli; Muthiah Manoharan
Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
ACS chemical biology 2006;1(3):176-83.
2006: Feng Li; Sanjay Sarkhel; Christopher J Wilds; Zdzislaw Wawrzak; Thazha P Prakash; Muthiah Manoharan; Martin Egli
2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry 2006;45(13):4141-52.
2006: Hong Zang; adriana irimia; Jeong-Yun Choi; Karen C Angel; Lioudmila V Loukachevitch; Martin Egli; F Peter Guengerich
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.
The Journal of biological chemistry 2006;281(4):2358-72.
2005: Pradeep S Pallan; William S Marshall; Joel Harp; Frederic C Jewett; Zdzislaw Wawrzak; Bernard A Brown; Alexander Rich; Martin Egli
Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif.
Biochemistry 2005;44(34):11315-22.
2005: Hong Zang; Angela K Goodenough; Jeong-Yun Choi; adriana irimia; Lioudmila V Loukachevitch; Ivan D Kozekov; Karen C Angel; Carmelo J Rizzo; Martin Egli; F Peter Guengerich
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
The Journal of biological chemistry 2005;280(33):29750-64.
2005: Martin Egli; George Minasov; Valentina Tereshko; Pradeep S Pallan; Marianna Teplova; Gopal B Inamati; Elena A Lesnik; Steve R Owens; Bruce S Ross; Thazha P Prakash; Muthiah Manoharan
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry 2005;44(25):9045-57.
2005: Benjamin Diop-Frimpong; Thazha P Prakash; Kallanthottathil G Rajeev; Muthiah Manoharan; Martin Egli
Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.
Nucleic acids research 2005;33(16):5297-307.
2005: Peter Haeberli; Imre Berger; Pradeep S Pallan; Martin Egli
Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine.
Nucleic acids research 2005;33(13):3965-75.
2004: Martin Egli
Nucleic acid crystallography: current progress.
Current opinion in chemical biology 2004;8(6):580-91.
2004: Rekha Pattanayek; Latsavongsakda Sethaphong; Chongle Pan; Marija Prhavc; Thazha P Prakash; Muthiah Manoharan; Martin Egli
Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
Journal of the American Chemical Society 2004;126(46):15006-7.
2004: Yao Xu; Tetsuya Mori; Rekha Pattanayek; Sabuj Pattanayek; Martin Egli; Carl Hirschie Johnson
Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13933-8.
2004: Rekha Pattanayek; Jimin Wang; Tetsuya Mori; Yao Xu; Carl Hirschie Johnson; Martin Egli
Visualizing a circadian clock protein: crystal structure of KaiC and functional insights.
Molecular cell 2004;15(3):375-88.
2004: Martin Egli
"Deoxyribo nanonucleic acid"; antiparallel, parallel, and unparalleled.
Chemistry & biology 2004;11(8):1027-9.
2004: Thazha P Prakash; Ask Püschl; Elena A Lesnik; Venkatraman Mohan; Valentina Tereshko; Martin Egli; Muthiah Manoharan
2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.
Organic letters 2004;6(12):1971-4.
2003: Anastasia V Velentza; Mark S Wainwright; Magdalena Zasadzki; Salida Mirzoeva; Andrew M Schumacher; jacques haiech; Pamela J Focia; Martin Egli; D Martin Watterson
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Bioorganic & medicinal chemistry letters 2003;13(20):3465-70.
2003: Martin Egli; Valentina Tereshko; Garib N Mushudov; Ruslan Sanishvili; Xiaoyang Liu; Frederick D Lewis
Face-to-face and edge-to-face pi-pi interactions in a synthetic DNA hairpin with a stilbenediether linker.
Journal of the American Chemical Society 2003;125(36):10842-9.
2003: Sanjay Sarkhel; Alexander Rich; Martin Egli
Water-nucleobase "stacking": H-pi and lone pair-pi interactions in the atomic resolution crystal structure of an RNA pseudoknot.
Journal of the American Chemical Society 2003;125(30):8998-9.
2003: Marija Prhavc; Thazha P Prakash; George Minasov; P Dan Cook; Martin Egli; Muthiah Manoharan
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.
Organic letters 2003;5(12):2017-20.
2003: Pradeep S Pallan; Christopher J Wilds; Zdzislaw Wawrzak; Ramanarayanan Krishnamurthy; Albert Eschenmoser; Martin Egli
Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
Angewandte Chemie (International ed. in English) 2003;42(47):5893-5.
2002: Christopher J Wilds; Rekha Pattanayek; Chongle Pan; Zdzislaw Wawrzak; Martin Egli
Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure.
Journal of the American Chemical Society 2002;124(50):14910-6.
2002: Christopher J Wilds; Zdzislaw Wawrzak; Ramanarayanan Krishnamurthy; Albert Eschenmoser; Martin Egli
Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA.
Journal of the American Chemical Society 2002;124(46):13716-21.
2002: Thazha P Prakash; Muthiah Manoharan; Andrew M Kawasaki; Allister S Fraser; Elena A Lesnik; Namir Sioufi; Janet M Leeds; Marianna Teplova; Martin Egli
2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.
Biochemistry 2002;41(39):11642-8.
2002: Marianna Teplova; Christopher J Wilds; Zdzislaw Wawrzak; Valentina Tereshko; Quan Du; Nicolas Carrasco; Zhen Huang; Martin Egli
Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion.
Biochimie 2002;84(9):849-58.
2002: Martin Egli; George Minasov; Li Su; Alexander Rich
Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4302-7.
2002: Martin Egli
DNA-cation interactions: quo vadis?
Chemistry & biology 2002;9(3):277-86.
2002: Quan Du; Nicolas Carrasco; Marianna Teplova; Christopher J Wilds; Martin Egli; Zhen Huang
Internal derivatization of oligonucleotides with selenium for X-ray crystallography using MAD.
Journal of the American Chemical Society 2002;124(1):24-5.
2002: Christopher J Wilds; Martin A Maier; Valentina Tereshko; Muthiah Manoharan; Martin Egli
Direct observation of a cytosine analogue that forms five hydrogen bonds to guanosine: guanidino G-clamp.
Angewandte Chemie (International ed. in English) 2002;41(1):115-7.
2001: Anastasia V Velentza; Andrew M Schumacher; C Weiss; Martin Egli; D Martin Watterson
A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.
The Journal of biological chemistry 2001;276(42):38956-65.
2001: Valentina Tereshko; Marianna Teplova; Joseph S. Brunzelle; D Martin Watterson; Martin Egli
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nature structural biology 2001;8(10):899-907.
2001: Christopher J Wilds; George Minasov; F Natt; Peter von Matt; Karl-Heinz Altmann; Martin Egli
Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):991-4.
2001: Valentina Tereshko; S T Wallace; N Usman; FE Wincott; Martin Egli
X-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.
RNA (New York, N.Y.) 2001;7(3):405-20.
2001: Valentina Tereshko; Christopher J Wilds; George Minasov; Thazha P Prakash; Martin A Maier; A Howard; Zdzislaw Wawrzak; Muthiah Manoharan; Martin Egli
Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic acids research 2001;29(5):1208-15.
2000: Marianna Teplova; Valentina Tereshko; Ruslan Sanishvili; Andrzej Joachimiak; T Bushueva; Wayne F Anderson; Martin Egli
The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding.
Protein science : a publication of the Protein Society 2000;9(12):2557-66.
2000: George Minasov; Jasenka Matulic-Adamic; Christopher J Wilds; Peter Haeberli; N Usman; Leonid Beigelman; Martin Egli
Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.
RNA (New York, N.Y.) 2000;6(11):1516-28.
2000: George Minasov; Marianna Teplova; G C Stewart; E V Koonin; Wayne F Anderson; Martin Egli
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6328-33.
2000: George Minasov; Marianna Teplova; P Nielsen; J Wengel; Martin Egli
Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA.
Biochemistry 2000;39(13):3525-32.
1999: Marianna Teplova; S T Wallace; Valentina Tereshko; George Minasov; AM Symons; P Dan Cook; Muthiah Manoharan; Martin Egli
Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14240-5.
1999: George Minasov; Valentina Tereshko; Martin Egli
Atomic-resolution crystal structures of B-DNA reveal specific influences of divalent metal ions on conformation and packing.
Journal of molecular biology 1999;291(1):83-99.
1999: Marianna Teplova; George Minasov; Valentina Tereshko; Gopal B Inamati; P Dan Cook; Muthiah Manoharan; Martin Egli
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nature structural biology 1999;6(6):535-9.
1998: V Tereshko; S Portmann; E C Tay; P Martin; F Natt; Karl-Heinz Altmann; Martin Egli
Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.
Biochemistry 1998;37(30):10626-34.
1998: I Berger; Valentina Tereshko; H Ikeda; V E Marquez; Martin Egli
Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Nucleic acids research 1998;26(10):2473-80.
1998: Martin Egli; Valentina Tereshko; Marianna Teplova; George Minasov; Andrzej Joachimiak; Ruslan Sanishvili; C M Weeks; R Miller; Martin A Maier; H An; P Dan Cook; Muthiah Manoharan
X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution.
Biopolymers 1998;48(4):234-52.
1996: I Berger; Martin Egli; Alexander Rich
Inter-strand C-H...O hydrogen bonds stabilizing four-stranded intercalated molecules: stereoelectronic effects of O4' in cytosine-rich DNA.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12116-21.
1996: Martin Egli; S Portmann; N Usman
RNA hydration: a detailed look.
Biochemistry 1996;35(26):8489-94.
1995: Martin Egli; S Portmann; D Tracz; C Workman; N Usman
Crystallization and preliminary X-ray diffraction analysis of double-helical RNA octamers.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 6):1065-70.
1995: B Hyrup; C Richert; T Schulte-Herbrüggen; S A Benner; Martin Egli
X-ray crystal structure of a dimethylene sulfone-bridged ribonucleotide dimer in a single-stranded state.
Nucleic acids research 1995;23(13):2427-33.
1995: S Portmann; N Usman; Martin Egli
The crystal structure of r(CCCCGGGG) in two distinct lattices.
Biochemistry 1995;34(23):7569-75.
1995: Martin Egli; R V Gessner
Stereoelectronic effects of deoxyribose O4' on DNA conformation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):180-4.
1994: S Zhang; Martin Egli
A hypothesis: reciprocal information transfer between oligoribonucleotides and oligopeptides in prebiotic molecular evolution.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 1994;24(6):495-505.
1994: R V Gessner; G J Quigley; Martin Egli
Comparative studies of high resolution Z-DNA crystal structures. Part 1: Common hydration patterns of alternating dC-dG.
Journal of molecular biology 1994;236(4):1154-68.
1994: D Bancroft; L D Williams; Alexander Rich; Martin Egli
The low-temperature crystal structure of the pure-spermine form of Z-DNA reveals binding of a spermine molecule in the minor groove.
Biochemistry 1994;33(5):1073-86.
1993: Martin Egli; N Usman; Alexander Rich
Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes.
Biochemistry 1993;32(13):3221-37.
1992: N Usman; Martin Egli; Alexander Rich
Large scale chemical synthesis, purification and crystallization of RNA-DNA chimeras.
Nucleic acids research 1992;20(24):6695-9.
1992: Martin Egli; N Usman; S G Zhang; Alexander Rich
Crystal structure of an Okazaki fragment at 2-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):534-8.
1991: Martin Egli; L D Williams; Q Gao; Alexander Rich
Structure of the pure-spermine form of Z-DNA (magnesium free) at 1-A resolution.
Biochemistry 1991;30(48):11388-402.
1991: Q Gao; L D Williams; Martin Egli; D Rabinovich; S L Chen; G J Quigley; Alexander Rich
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2422-6.
1991: Martin Egli; L D Williams; C A Frederick; Alexander Rich
DNA-nogalamycin interactions.
Biochemistry 1991;30(5):1364-72.
1990: L D Williams; Martin Egli; G Ughetto; G A van der Marel; J H van Boom; G J Quigley; A H Wang; Alexander Rich; C A Frederick
Structure of 11-deoxydaunomycin bound to DNA containing a phosphorothioate.
Journal of molecular biology 1990;215(2):313-20.
1990: Martin Egli; R V Gessner; L D Williams; G J Quigley; G A van der Marel; J H van Boom; Alexander Rich; C A Frederick
Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3235-9.
1990: L D Williams; Martin Egli; G Qi; P Bash; G A van der Marel; J H van Boom; Alexander Rich; C A Frederick
Structure of nogalamycin bound to a DNA hexamer.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2225-9.