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Patricia Egner

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Thomas W Kensler; Kala Visvanathan; Abena S Agyeman; Jian-Guo Chen; Tao-Yang Chen; Patricia A Egner; Jed W Fahey; John Groopman; Paul Talalay
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
Roongtiwa Wattanawaraporn; Leslie L Woo; Jillian E Adams; Crystal Belanger; Jason T Bouhenguel; Shiou-Chi Chang; Robert G Croy; Patricia A Egner; John M Essigmann; John Groopman; Laura J Trudel; Gerald N Wogan
A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.
Jed W Fahey; W David Holtzclaw; Thomas W Kensler; Theresa A Shapiro; Patricia A Egner; Scott L Wehage; Paul Talalay
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

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2013: Thomas W Kensler; Kala Visvanathan; Abena S Agyeman; Jian-Guo Chen; Tao-Yang Chen; Patricia A Egner; Jed W Fahey; John Groopman; Paul Talalay
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.
Topics in current chemistry 2013;329():163-77.
2012: Roongtiwa Wattanawaraporn; Leslie L Woo; Jillian E Adams; Crystal Belanger; Jason T Bouhenguel; Shiou-Chi Chang; Robert G Croy; Patricia A Egner; John M Essigmann; John Groopman; Laura J Trudel; Gerald N Wogan
A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 2012;128(2):326-33.
2012: Jed W Fahey; W David Holtzclaw; Thomas W Kensler; Theresa A Shapiro; Patricia A Egner; Scott L Wehage; Paul Talalay
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):603-11.
2012: Thomas W Kensler; Patricia A Egner; Tao Yang Chen; Menglan Chen; Alvaro Muñoz; Steven G Carmella; Derek Ng; Geng Sun Qian; Paul Talalay; John Groopman; Jian Guo Chen; Lisa P Jacobson; Jed W Fahey; Jian-Min Yuan; Stephen S Hecht
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.
Carcinogenesis 2012;33(1):101-7.
2011: Leslie L Woo; Crystal L Belanger; Robert G Croy; Patricia A Egner; John M Essigmann; John Groopman; Laura J Trudel; Roongtiwa Wattanawaraporn; Gerald N Wogan; Jason T Bouhenguel
Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2011;122(1):38-44.
2011: ALVARO MUNOZ; Jian Guo Chen; Patricia A Egner; Melinda L Marshall; Jamie L Johnson; Michael F Schneider; Jian Hua Lu; Yuan-Rong Zhu; Jin-Bing Wang; Tao Yang Chen; Thomas W Kensler; John Groopman
Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China.
Carcinogenesis 2011;32(6):860-5.
2011: Jeannette L A Fiala; Patricia A Egner; Nirachara Wiriyachan; Mathuros Ruchirawat; Kevin H Kensler; Gerald N Wogan; John Groopman; Robert G Croy; John M Essigmann
Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(1):57-62.
2011: Patricia A Egner; Jian Guo Chen; Jin Bing Wang; Yan Wu; Yan Sun; Jian Hua Lu; Jian Zhu; Yong Hui Zhang; Yong Sheng Chen; Marlin Friesen; Lisa P Jacobson; ALVARO MUNOZ; Derek Ng; Geng-Sun Qian; Yuan Rong Zhu; Tao Yang Chen; Nigel P Botting; Qingzhi Zhang; Jed W Fahey; Paul Talalay; John Groopman; Thomas W Kensler
Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China.
Cancer prevention research (Philadelphia, Pa.) 2011;4(3):384-95.
2010: Zoran Ilic; Dana Crawford; Dilip Vakharia; Patricia A Egner; Stewart Sell
Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1.
Toxicology and applied pharmacology 2010;242(3):241-6.
2010: Michael Fasullo; Yifan Chen; William Bortcosh; Minzeng Sun; Patricia A Egner
Aflatoxin B(1)-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae.
Journal of nucleic acids 2010;2010():456487.
2009: Bill D Roebuck; Denise N Johnson; Carrie Hayes Sutter; Patricia A Egner; Peter F Scholl; Marlin Friesen; Karen J Baumgartner; Nicholas M Ware; Sridevi Bodreddigari; John Groopman; Thomas W Kensler; Thomas R Sutter
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):41-9.
2008: Patricia A Egner; Thomas W Kensler; Jian-Guo Chen; Stephen J Gange; John Groopman; Marlin Friesen
Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry.
Chemical research in toxicology 2008;21(10):1991-6.
2008: Karen Liby; Mark M Yore; Bill D Roebuck; Karen J Baumgartner; Tadashi Honda; Chitra Sundararajan; Hidenori Yoshizawa; Gordon W Gribble; Charlotte R Williams; Renee Risingsong; Darlene B Royce; Albena T Dinkova-Kostova; Katherine K Stephenson; Patricia A Egner; Melinda S Yates; John Groopman; Thomas W Kensler; Michael B. Sporn
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Cancer research 2008;68(16):6727-33.
2008: Michael Fasullo; Mingzeng Sun; Patricia A Egner
Stimulation of sister chromatid exchanges and mutation by aflatoxin B1-DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53, and DUN1.
Molecular carcinogenesis 2008;47(8):608-15.
2008: Sridevi Bodreddigari; Laundette Knight Jones; Patricia A Egner; John Groopman; Carrie Hayes Sutter; Bill D Roebuck; F Peter Guengerich; Thomas W Kensler; Thomas R Sutter
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
Chemical research in toxicology 2008;21(5):1134-42.
2008: Denise N Johnson; Patricia A Egner; Greg Obrian; Norman Glassbrook; Bill D Roebuck; Thomas R Sutter; Gary A Payne; Thomas W Kensler; John Groopman
Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry.
Chemical research in toxicology 2008;21(3):752-60.
2007: Jian-Guo Chen; Shuang-Yuan Kuang; Patricia A Egner; Jian Hua Lu; Yuan-Rong Zhu; Jin-Bing Wang; Bao-Chu Zhang; Tao Yang Chen; ALVARO MUNOZ; Thomas W Kensler; John Groopman
Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1213-8.
2007: Michael T Simonich; Patricia A Egner; Bill D Roebuck; Gayle A Orner; Carole Jubert; Cliff Pereira; John Groopman; Thomas W Kensler; Roderick H Dashwood; David E Williams; George S Bailey
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.
Carcinogenesis 2007;28(6):1294-302.
2006: Xiang Yu; Patricia A Egner; Junko Wakabayashi; Nobunao Wakabayashi; Masayuki Yamamoto; Thomas W Kensler
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase.
The Journal of biological chemistry 2006;281(36):26245-52.
2006: Patricia A Egner; John Groopman; Jia-Sheng Wang; Thomas W Kensler; Marlin Friesen
Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.
Chemical research in toxicology 2006;19(9):1191-5.
2006: Paul L Skipper; Laura J Trudel; Thomas W Kensler; John Groopman; Patricia A Egner; Rosa G Liberman; Gerald N Wogan; Steven R Tannenbaum
DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice.
Chemical research in toxicology 2006;19(8):1086-90.
2006: Melinda S Yates; Mi-Kyoung Kwak; Patricia A Egner; John Groopman; Sridevi Bodreddigari; Thomas R Sutter; Karen J Baumgartner; Bill D Roebuck; Karen T Liby; Mark M Yore; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Thomas W Kensler
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
Cancer research 2006;66(4):2488-94.
2005: Thomas W Kensler; Jian-Guo Chen; Patricia A Egner; Jed W Fahey; Lisa P Jacobson; Katherine K Stephenson; Lingxiang Ye; Jamie L Coady; Jin-Bing Wang; Yan Wu; Yan Sun; Qi-Nan Zhang; Bao-Chu Zhang; Yuan-Rong Zhu; Geng-Sun Qian; Stephen G Carmella; Stephen S Hecht; Lorie Benning; Stephen J Gange; John Groopman; Paul Talalay
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(11 Pt 1):2605-13.
2005: Jed W Fahey; Katherine K Stephenson; Albena T Dinkova-Kostova; Patricia A Egner; Thomas W Kensler; Paul Talalay
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
Carcinogenesis 2005;26(7):1247-55.
2004: Thomas W Kensler; Patricia A Egner; Jin-Bing Wang; Yuan-Rong Zhu; Bao-Chu Zhang; Pei-Xing Lu; Jian-Guo Chen; Geng-Sun Qian; Shuang-Yuan Kuang; Peta E Jackson; Stephen J Gange; Lisa P Jacobson; ALVARO MUNOZ; John Groopman
Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas.
Gastroenterology 2004;127(5 Suppl 1):S310-8.
2003: Patricia A Egner; Xiang Yu; Jesse K Johnson; Christopher K Nathasingh; John Groopman; Thomas W Kensler; Bill D Roebuck
Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1.
Chemical research in toxicology 2003;16(9):1174-80.
2003: Patricia A Egner; ALVARO MUNOZ; Thomas W Kensler
Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin.
Mutation research 2003;523-524():209-16.
2002: Thomas W Kensler; Patricia A Egner; Jin-Bing Wang; Yuan-Rong Zhu; Bao-Chu Zhang; Geng-Sun Qian; Shuang-Yuan Kuang; Stephen J Gange; Lisa P Jacobson; ALVARO MUNOZ; John Groopman
Strategies for chemoprevention of liver cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2002;11 Suppl 2():S58-64.
2001: Patricia A Egner; Jin-Bing Wang; Yuan-Rong Zhu; Bao-Chu Zhang; Yan Wu; Qi-Nan Zhang; Geng-Sun Qian; Shuang-Yuan Kuang; Stephen J Gange; Lisa P Jacobson; Kathy J Helzlsouer; George S Bailey; John Groopman; Thomas W Kensler
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(25):14601-6.
2001: Mi-Kyoung Kwak; Patricia A Egner; Patrick Dolan; Minerva Ramos-Gomez; John Groopman; Ken Itoh; Masayuki Yamamoto; Thomas W Kensler
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Mutation research 2001;480-481():305-15.
2001: M Walton; Patricia A Egner; Peter F Scholl; J Walker; Thomas W Kensler; John Groopman
Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats.
Chemical research in toxicology 2001;14(7):919-26.
2001: Anna Camoirano; Marcello Bagnasco; Carlo Bennicelli; Cristina Cartiglia; Jin-Bing Wang; Bao-Chu Zhang; Yuan-Rong Zhu; Geng-Sun Qian; Patricia A Egner; Lisa P Jacobson; Thomas W Kensler; Silvio De Flora
Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(7):775-83.
2000: Patricia A Egner; KH Stansbury; E P Snyder; ME Rogers; P A Hintz; Thomas W Kensler
Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial.
Chemical research in toxicology 2000;13(9):900-6.
2000: Yuan Li; J Su; L Qin; Patricia A Egner; Jia-Sheng Wang; John Groopman; Thomas W Kensler; Bill D Roebuck
Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis).
Cancer letters 2000;154(1):79-83.
1999: Jia-Sheng Wang; X Shen; Xia He; Yuan-Rong Zhu; Bao-Chu Zhang; Jin-Bing Wang; Geng-Sun Qian; Shuang-Yuan Kuang; A Zarba; Patricia A Egner; Lisa P Jacobson; ALVARO MUNOZ; Kathy J Helzlsouer; John Groopman; Thomas W Kensler
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
Journal of the National Cancer Institute 1999;91(4):347-54.
1998: Thomas W Kensler; Xia He; MA Otieno; Patricia A Egner; Lisa P Jacobson; B Chen; Jia-Sheng Wang; Yuan-Rong Zhu; Bao-Chu Zhang; Jin-Bing Wang; Yan Wu; Qi-Nan Zhang; Geng-Sun Qian; Shuang-Yuan Kuang; X Fang; YF Li; LY Yu; HJ Prochaska; Nancy E Davidson; GB Gordon; MB Gorman; A Zarba; CL Enger; ALVARO MUNOZ; Kathy J Helzlsouer
Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(2):127-34.
1997: Thomas W Kensler; Stephen J Gange; Patricia A Egner; Patrick Dolan; ALVARO MUNOZ; John Groopman; A E Rogers; Bill D Roebuck
Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(8):603-10.
1997: Lisa P Jacobson; Bao-Chu Zhang; Yuan-Rong Zhu; Jin-Bing Wang; Yan Wu; Qi-Nan Zhang; LY Yu; Geng-Sun Qian; Shuang-Yuan Kuang; YF Li; X Fang; A Zarba; B Chen; CL Enger; Nancy E Davidson; MB Gorman; GB Gordon; HJ Prochaska; Patricia A Egner; John Groopman; ALVARO MUNOZ; Kathy J Helzlsouer; Thomas W Kensler
Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(4):257-65.
1997: Bao-Chu Zhang; Yuan-Rong Zhu; Jin-Bing Wang; Yan Wu; Qi-Nan Zhang; Geng-Sun Qian; Shuang-Yuan Kuang; YF Li; X Fang; LY Yu; Silvio De Flora; Lisa P Jacobson; A Zarba; Patricia A Egner; Xia He; Jia-Sheng Wang; B Chen; CL Enger; Nancy E Davidson; GB Gordon; MB Gorman; HJ Prochaska; John Groopman; ALVARO MUNOZ; Thomas W Kensler
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
Journal of cellular biochemistry. Supplement 1997;28-29():166-73.
1996: J K King; Patricia A Egner; Thomas W Kensler
Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide.
Carcinogenesis 1996;17(2):317-20.
1995: T Primiano; Patricia A Egner; Thomas R Sutter; G J Kelloff; Bill D Roebuck; Thomas W Kensler
Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.
Cancer research 1995;55(19):4319-24.
1995: Patricia A Egner; Stephen J Gange; Patrick Dolan; John Groopman; ALVARO MUNOZ; Thomas W Kensler
Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz.
Carcinogenesis 1995;16(8):1769-73.
1995: Thomas W Kensler; K Guyton; Patricia A Egner; T McCarthy; S Lesko; S Akman
Role of reactive intermediates in tumor promotion and progression.
Progress in clinical and biological research 1995;391():103-16.
1994: Patricia A Egner; Thomas W Kensler; T Prestera; Paul Talalay; A H Libby; H H Joyner; Thomas J Curphey
Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones.
Carcinogenesis 1994;15(2):177-81.
1994: Michael A Trush; Patricia A Egner; Thomas W Kensler
Myeloperoxidase as a biomarker of skin irritation and inflammation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(2):143-7.
1992: John Groopman; P DeMatos; Patricia A Egner; A Love-Hunt; Thomas W Kensler
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Carcinogenesis 1992;13(1):101-6.
1990: Nancy E Davidson; Patricia A Egner; Thomas W Kensler
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.
Cancer research 1990;50(8):2251-5.
1989: Thomas W Kensler; Patricia A Egner; B G Taffe; Michael A Trush
Role of free radicals in tumor promotion and progression.
Progress in clinical and biological research 1989;298():233-48.
1987: Thomas W Kensler; Patricia A Egner; K G Moore; B G Taffe; L E Twerdok; Michael A Trush
Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin.
Toxicology and applied pharmacology 1987;90(2):337-46.
1987: Thomas W Kensler; Patricia A Egner; Patrick Dolan; John Groopman; Bill D Roebuck
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Cancer research 1987;47(16):4271-7.
1986: Thomas W Kensler; Patricia A Egner; Nancy E Davidson; Bill D Roebuck; A Pikul; John Groopman
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.
Cancer research 1986;46(8):3924-31.
1985: Patricia A Egner; Thomas W Kensler
Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin.
Carcinogenesis 1985;6(8):1167-72.
1985: Thomas W Kensler; Patricia A Egner; Michael A Trush; E Bueding; John Groopman
Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.
Carcinogenesis 1985;6(5):759-63.