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Linda Ehler

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Mark Dybul; Elizabeth Nies-Kraske; Robin L Dewar; Frank Maldarelli; Claire W Hallahan; Marybeth Daucher; Stephen C Piscitelli; Linda Ehler; Ann Weigand; Sarah Palmer; Julia A Metcalf; Richard Davey; Diane Rock Kress; April Powers; Ingrid Beck; Lisa Frenkel; Michael Baseler; John M Coffin; Anthony Fauci
A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection.
Mark Dybul; Elizabeth Nies-Kraske; Marybeth Daucher; Kurt Hertogs; Claire W Hallahan; Gyorgy Csako; Christian Yoder; Linda Ehler; Peter A Sklar; Michael Belson; Bertha Hidalgo; Julia A Metcalf; Richard Davey; Diane Rock Kress; April Powers; Anthony Fauci
Long-cycle structured intermittent versus continuous highly active antiretroviral therapy for the treatment of chronic infection with human immunodeficiency virus: effects on drug toxicity and on immunologic and virologic parameters.
Angela Malaspina; Susan Moir; Shyam Kottilil; Claire W Hallahan; Linda Ehler; Shuying Liu; Marie A Planta; Tae-Wook Chun; Anthony Fauci
Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function.

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All Publications

2004: Mark Dybul; Elizabeth Nies-Kraske; Robin L Dewar; Frank Maldarelli; Claire W Hallahan; Marybeth Daucher; Stephen C Piscitelli; Linda Ehler; Ann Weigand; Sarah Palmer; Julia A Metcalf; Richard Davey; Diane Rock Kress; April Powers; Ingrid Beck; Lisa Frenkel; Michael Baseler; John M Coffin; Anthony Fauci
A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection.
The Journal of infectious diseases 2004;189(11):1974-82.
2003: Mark Dybul; Elizabeth Nies-Kraske; Marybeth Daucher; Kurt Hertogs; Claire W Hallahan; Gyorgy Csako; Christian Yoder; Linda Ehler; Peter A Sklar; Michael Belson; Bertha Hidalgo; Julia A Metcalf; Richard Davey; Diane Rock Kress; April Powers; Anthony Fauci
Long-cycle structured intermittent versus continuous highly active antiretroviral therapy for the treatment of chronic infection with human immunodeficiency virus: effects on drug toxicity and on immunologic and virologic parameters.
The Journal of infectious diseases 2003;188(3):388-96.
2003: Angela Malaspina; Susan Moir; Shyam Kottilil; Claire W Hallahan; Linda Ehler; Shuying Liu; Marie A Planta; Tae-Wook Chun; Anthony Fauci
Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):5965-72.
2003: Stephen A Migueles; Alisha C Laborico; Hiromi Imamichi; W Lesley Shupert; Cassandra Royce; Mary McLaughlin; Linda Ehler; Julia Metcalf; Shuying Liu; Claire W Hallahan; Mark Connors
The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences.
Journal of virology 2003;77(12):6889-98.
2003: Susan Moir; Kisani M Ogwaro; Angela Malaspina; Joshua Vasquez; Eileen T Donoghue; Claire W Hallahan; Shuying Liu; Linda Ehler; Marie A Planta; Shyam Kottilil; Tae-Wook Chun; Anthony Fauci
Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6057-62.
2003: Audrey L Kinter; Craig A Umscheid; James Arthos; Claudia Cicala; Yin Lin; Robert Jackson; Eileen T Donoghue; Linda Ehler; Joseph W Adelsberger; Ronald L Rabin; Anthony Fauci
HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2449-55.
2003: Mark Dybul; Marybeth Daucher; Mark A Jensen; Claire W Hallahan; Tae-Wook Chun; Michael Belson; Bertha Hidalgo; David C Nickle; Christian Yoder; Julia A Metcalf; Richard Davey; Linda Ehler; Diane Kress-Rock; Elizabeth Nies-Kraske; Shuying Liu; James I Mullins; Anthony Fauci
Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapy.
Journal of virology 2003;77(5):3229-37.
2003: Tae-Wook Chun; J Shawn Justement; Richard A Lempicki; Jun Yang; Glynn Dennis; Claire W Hallahan; Christina Sanford; Punita Pandya; Shuying Liu; Mary McLaughlin; Linda Ehler; Susan Moir; Anthony Fauci
Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1908-13.
2002: Stephen A Migueles; Alisha C Laborico; W Lesley Shupert; M Shirin Sabbaghian; Ronald L Rabin; Claire W Hallahan; Debbie Van Baarle; Stefan Kostense; Frank Miedema; Mary McLaughlin; Linda Ehler; Julia Metcalf; Shuying Liu; Mark Connors
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.
Nature immunology 2002;3(11):1061-8.
2002: Angela Malaspina; Susan Moir; David C Nickle; Eileen T Donoghue; Kisani M Ogwaro; Linda Ehler; Shuying Liu; Jo Ann M Mican; Mark Dybul; Tae-Wook Chun; James I Mullins; Anthony Fauci
Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma.
Journal of virology 2002;76(17):8855-63.
2002: Tae-Wook Chun; J Shawn Justement; Punita Pandya; Claire W Hallahan; Mary McLaughlin; Shuying Liu; Linda Ehler; Colin Kovacs; Anthony Fauci
Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy.
The Journal of infectious diseases 2002;185(11):1672-6.
2001: Susan Moir; Angela Malaspina; Kisani M Ogwaro; Eileen T Donoghue; Claire W Hallahan; Linda Ehler; Shiquan Liu; Joseph W Adelsberger; Réjean Lapointe; Patrick Hwu; Michael Baseler; Jan M Orenstein; Tae-Wook Chun; Jo Ann M Mican; Anthony Fauci
HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10362-7.
2001: Tae-Wook Chun; J Shawn Justement; Susan Moir; Claire W Hallahan; Linda Ehler; Shiquan Liu; Mary McLaughlin; Mark Dybul; JoAnn M Mican; Anthony Fauci
Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):253-8.
2000: Mario A Ostrowski; SJ Justement; Linda Ehler; SB Mizell; S Lui; JoAnn M Mican; B D Walker; E K Thomas; Robert A Seder; Anthony Fauci
The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6133-41.
2000: Susan Moir; Angela Malaspina; Y Li; Tae-Wook Chun; T Lowe; Joseph W Adelsberger; Michael Baseler; Linda Ehler; Shiquan Liu; Richard Davey; Jo Ann M Mican; Anthony Fauci
B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells.
The Journal of experimental medicine 2000;192(5):637-46.
2000: Mark Dybul; G Mercier; Michael Belson; Claire W Hallahan; Shuying Liu; C Perry; Betsey Herpin; Linda Ehler; Richard Davey; Julia A Metcalf; JoAnn M Mican; Robert A Seder; Anthony Fauci
CD40 ligand trimer and IL-12 enhance peripheral blood mononuclear cells and CD4+ T cell proliferation and production of IFN-gamma in response to p24 antigen in HIV-infected individuals: potential contribution of anergy to HIV-specific unresponsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1685-91.
2000: JC Gea-Banacloche; Stephen A Migueles; L Martino; W Lesley Shupert; AC McNeil; M Shirin Sabbaghian; Linda Ehler; C Prussin; R Stevens; Laurie Lambert; John D Altman; Claire W Hallahan; J C de Quiros; Mark Connors
Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):1082-92.
2000: H Moriuchi; M Moriuchi; SB Mizell; Linda Ehler; Anthony Fauci
In vitro reactivation of human immunodeficiency virus 1 from latently infected, resting CD4+ T cells after bacterial stimulation.
The Journal of infectious diseases 2000;181(6):2041-4.
1999: Mario A Ostrowski; Tae-Wook Chun; SJ Justement; Ivette Motola; M A Spinelli; Joseph W Adelsberger; Linda Ehler; SB Mizell; Claire W Hallahan; Anthony Fauci
Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals.
Journal of virology 1999;73(8):6430-5.
1998: Mario A Ostrowski; D C Krakauer; Y Li; SJ Justement; Gerald Learn; Linda Ehler; S K Stanley; M Nowak; Anthony Fauci
Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies.
Journal of virology 1998;72(10):7772-84.
1998: Audrey L Kinter; AT Catanzaro; J Monaco; M Ruiz; J Shawn Justement; Susan Moir; James Arthos; A Oliva; Linda Ehler; SB Mizell; Robert Jackson; M Ostrowski; James A Hoxie; R Offord; Anthony Fauci
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11880-5.
1998: Mario A Ostrowski; SJ Justement; AT Catanzaro; C A Hallahan; Linda Ehler; SB Mizell; P N Kumar; Jo Ann M Mican; Tae-Wook Chun; Anthony Fauci
Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3195-201.
1998: Mark Dybul; Drew Weissman; A Rubbert; Elizabeth Machado; M Cohn; Linda Ehler; M O'Callahan; SB Mizell; Anthony Fauci
The role of dendritic cells in the infection of CD4+ T cells with the human immunodeficiency virus: use of dendritic cells from individuals homozygous for the delta32CCR5 allele as a model.
AIDS research and human retroviruses 1998;14(13):1109-13.
1998: Tae-Wook Chun; D Engel; SB Mizell; Linda Ehler; Anthony Fauci
Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines.
The Journal of experimental medicine 1998;188(1):83-91.
1998: A Oliva; Audrey L Kinter; M Vaccarezza; A Rubbert; AT Catanzaro; Susan Moir; J Monaco; Linda Ehler; SB Mizell; Robert Jackson; Y Li; J W Romano; Anthony Fauci
Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro.
The Journal of clinical investigation 1998;102(1):223-31.
1997: Tae-Wook Chun; Lieven Stuyver; SB Mizell; Linda Ehler; Jo Ann M Mican; Michael Baseler; A L Lloyd; M A Nowak; Anthony Fauci
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13193-7.
1996: Audrey L Kinter; M Ostrowski; Delia Goletti; A Oliva; Drew Weissman; K Gantt; E Hardy; Robert Jackson; Linda Ehler; Anthony Fauci
HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous beta-chemokines and the viral inductive effects of other endogenous cytokines.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14076-81.