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Christian Ehnholm

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Chemicals & Drugs

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Pirkka-Pekka Laurila; Terho Lehtimäki; Daniel B Mirel; Jussi Naukkarinen; Matej Oresic; Aarno Palotie; Leena Peltonen; Olli T Raitakari; Aimo Ruokonen; Veikko Salomaa; Antti-Pekka Sarin; Sanni Söderlund; Jarkko Soronen; Ida Surakka; Jing Tang; Marja-Riitta Taskinen; Laxman Yetukuri; Christian Ehnholm; Johan G Eriksson; Tuulia Hyötyläinen; Marjo-Riitta Järvelin; Matti Jauhiainen; Antti Jula; Johannes Kettunen; Samuli Ripatti
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Markus Herrmann; Anthony C Keech; David R Sullivan; Anne-Sophie Veillard; Malcolm J Whiting; Christian Ehnholm
Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study.
Ilenia Minicocci; Anna Montali; Fabio Pannozzo; Giovanni Pigna; Fabiana Quagliarini; Marius Robert Robciuc; Maria Laura Sepe; Vincenzo Censi; Christian Ehnholm; Sergio Fazio; Claudia Gabiati; Matti Jauhiainen; Giancarlo Labbadia; Dieter Lütjohann; Marcello Arca
Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.

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All Publications

2013: Pirkka-Pekka Laurila; Terho Lehtimäki; Daniel B Mirel; Jussi Naukkarinen; Matej Oresic; Aarno Palotie; Leena Peltonen; Olli T Raitakari; Aimo Ruokonen; Veikko Salomaa; Antti-Pekka Sarin; Sanni Söderlund; Jarkko Soronen; Ida Surakka; Jing Tang; Marja-Riitta Taskinen; Laxman Yetukuri; Christian Ehnholm; Johan G Eriksson; Tuulia Hyötyläinen; Marjo-Riitta Järvelin; Matti Jauhiainen; Antti Jula; Johannes Kettunen; Samuli Ripatti
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):847-57.
2012: Markus Herrmann; Anthony C Keech; David R Sullivan; Anne-Sophie Veillard; Malcolm J Whiting; Christian Ehnholm
Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2012;50(12):2213-9.
2012: Ilenia Minicocci; Anna Montali; Fabio Pannozzo; Giovanni Pigna; Fabiana Quagliarini; Marius Robert Robciuc; Maria Laura Sepe; Vincenzo Censi; Christian Ehnholm; Sergio Fazio; Claudia Gabiati; Matti Jauhiainen; Giancarlo Labbadia; Dieter Lütjohann; Marcello Arca
Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.
The Journal of clinical endocrinology and metabolism 2012;97(7):E1266-75.
2012: Marius R Robciuc; Paulina Skrobuk; Matti Jauhiainen; Heikki A Koistinen; Vesa M Olkkonen; Kari Alitalo; Andrey Anisimov; Robert H Eckel; Christian Ehnholm
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
PloS one 2012;7(10):e46212.
2012: You Zhou; Marius R Robciuc; Martin Wabitsch; Hannele Yki-Järvinen; Christian Ehnholm; Anne Juuti; Marja Leivonen; Vesa M Olkkonen
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.
PloS one 2012;7(9):e45352.
2011: Marius R Robciuc; Henna Tyynismaa; Taneli Raivio; Aila Rissanen; Christian Ehnholm; Matti Jauhiainen; Jaakko Kaprio; Jussi Naukkarinen; Alfredo Ortega-Alonso; Kirsi H Pietiläinen
Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins.
Journal of lipid research 2011;52(8):1575-82.
2010: Melissa C Smart-Halajko; Marius R Robciuc; Jackie A Cooper; Matti Jauhiainen; Meena Kumari; Mika Kivimaki; Kay-Tee Khaw; S Matthijs Boekholdt; Nicholas J Wareham; Tom R Gaunt; Ian N M Day; Peter S Braund; Christopher P Nelson; Alistair Hall; Nilesh J Samani; Steve E Humphries; Christian Ehnholm; Philippa J Talmud
The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(11):2277-82.
2010: Sanni Söderlund; Hiroshi Watanabe; Christian Ehnholm; Matti Jauhiainen; Marja-Riitta Taskinen
Increased apolipoprotein E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic syndrome.
Metabolism: clinical and experimental 2010;59(10):1502-9.
2010: Marja-Riitta Taskinen; P J Barter; Christian Ehnholm; D R Sullivan; K Mann; R John Simes; J D Best; S Hamwood; A C Keech
Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes.
Diabetologia 2010;53(9):1846-55.
2010: C Oslakovic; M Jauhiainen; Christian Ehnholm; Björn Dahlbäck
The role of phospholipid transfer protein in lipoprotein-mediated neutralization of the procoagulant effect of anionic liposomes.
Journal of thrombosis and haemostasis : JTH 2010;8(4):766-72.
2010: Marius R Robciuc; Esa Tahvanainen; Matti Jauhiainen; Christian Ehnholm
Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.
Journal of lipid research 2010;51(4):824-31.
2010: Dana Bailey; Isabelle L Ruel; Anouar Hafiane; Haley Cochrane; Iulia Iatan; Matti Jauhiainen; Christian Ehnholm; Larbi Krimbou; Jacques Genest
Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis.
Journal of lipid research 2010;51(4):785-97.
2010: Pirkka-Pekka Laurila; Jussi Naukkarinen; Kati Kristiansson; Samuli Ripatti; Tuuli Kauttu; Kaisa Silander; Veikko Salomaa; Markus Perola; Pekka J Karhunen; Philip J Barter; Christian Ehnholm; Leena Peltonen
Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(2):346-52.
2010: Marius R Robciuc; Jari Metso; Anca Sima; Christian Ehnholm; Matti Jauhiainen
Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass.
Lipids in health and disease 2010;9():59.
2010: R John Simes; Merryn Voysey; Rachel O'Connell; Paul Glasziou; James D Best; Russell Scott; Christopher Pardy; Karen Byth; David R Sullivan; Christian Ehnholm; Anthony C Keech
A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.
PloS one 2010;5(1):e8580.
2009: Marja-Riitta Taskinen; David R Sullivan; Christian Ehnholm; Malcolm Whiting; Diana Zannino; R John Simes; Anthony C Keech; Philip J Barter
Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):950-5.
2009: Russell Scott; Richard O'Brien; Greg Fulcher; Chris Pardy; Michael D'Emden; Dana Tse; Marja-Riitta Taskinen; Christian Ehnholm; Anthony Keech
Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.
Diabetes care 2009;32(3):493-8.
2009: Cecilia Oslakovic; Michael J Krisinger; Astra Andersson; Matti Jauhiainen; Christian Ehnholm; Björn Dahlbäck
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins.
The Journal of biological chemistry 2009;284(9):5896-904.
2009: Shuhei Nakanishi; Riikka Vikstedt; Sanni Söderlund; Miriam Lee-Rueckert; Anne Hiukka; Christian Ehnholm; Mikko Muilu; Jari Metso; Jussi Naukkarinen; Leena Palotie; Petri T Kovanen; Matti Jauhiainen; Marja-Riitta Taskinen
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Journal of lipid research 2009;50(2):183-92.
2008: Josefin Ahnström; Olof Axler; Matti Jauhiainen; Veikko Salomaa; Aki S Havulinna; Christian Ehnholm; Ruth Frikke-Schmidt; Anne Tybjaerg-Hansen; Björn Dahlbäck
Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.
Journal of lipid research 2008;49(9):1912-7.
2008: Christina Christoffersen; Matti Jauhiainen; Markus Moser; Bo Porse; Christian Ehnholm; Michael Boesl; Björn Dahlbäck; Lars B Nielsen
Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice.
The Journal of biological chemistry 2008;283(4):1839-47.
2008: Daoguang Yan; Mikko I Mäyränpää; Jenny Wong; Julia Perttilä; Markku Lehto; Matti Jauhiainen; Petri T Kovanen; Christian Ehnholm; Andrew J Brown; Vesa M Olkkonen
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
The Journal of biological chemistry 2008;283(1):332-40.
2008: Wilfried Schgoer; Thomas Mueller; Matti Jauhiainen; Andreas Wehinger; Roland Gander; Ivan Tancevski; Karin Salzmann; Philipp Eller; Andreas Ritsch; Meinhard Haltmayer; Christian Ehnholm; Josef R Patsch; Bernhard Foeger
Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis.
Atherosclerosis 2008;196(1):219-26.
2007: Riikka Vikstedt; Jari Metso; Jukka Hakala; Vesa M Olkkonen; Christian Ehnholm; Matti Jauhiainen
Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.
Biochemistry 2007;46(42):11979-86.
2007: Mia Hedman; Raija Pahlman; Jouko Sundvall; Christian Ehnholm; Mikko Syvänne; Eero Jokinen; Matti Jauhiainen; Christer Holmberg; Marjatta Antikainen
Low HDL-C predicts the onset of transplant vasculopathy in pediatric cardiac recipients on pravastatin therapy.
Pediatric transplantation 2007;11(5):481-90.
2007: Daoguang Yan; Matti Jauhiainen; Reeni B Hildebrand; Ko Willems van Dijk; Theo Van berkel; Christian Ehnholm; Miranda van Eck; Vesa M Olkkonen
Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1618-24.
2007: Igor Bykov; Matti Jauhiainen; Vesa M Olkkonen; Sirkku Saarikoski; Christian Ehnholm; Sami Junnikkala; Antti Väkevä; Kai O Lindros; Seppo Meri
Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis.
Journal of hepatology 2007;46(5):907-14.
2007: Daoguang Yan; Markku Lehto; Laura Rasilainen; Jari Metso; Christian Ehnholm; Seppo Ylä-Herttuala; Matti Jauhiainen; Vesa M Olkkonen
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1108-14.
2007: Miranda van Eck; Dan Ye; Reeni B Hildebrand; J Kar Kruijt; Willeke de Haan; Menno Hoekstra; Patrick Rensen; Christian Ehnholm; Matti Jauhiainen; Theo Van berkel
Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice.
Circulation research 2007;100(5):678-85.
2007: Riikka Vikstedt; Dan Ye; Jari Metso; Reeni B Hildebrand; Theo Van berkel; Christian Ehnholm; Matti Jauhiainen; Miranda van Eck
Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):578-86.
2007: Niko L Setälä; Juha M Holopainen; Jari Metso; Susanne K Wiedmer; Gebrenegus Yohannes; Paavo K J Kinnunen; Christian Ehnholm; Matti Jauhiainen
Interfacial and lipid transfer properties of human phospholipid transfer protein: implications for the transfer mechanism of phospholipids.
Biochemistry 2007;46(5):1312-9.
2007: Ulrich Julius; Matti Jauhiainen; Christian Ehnholm; Jens Pietzsch
Lipid transfer protein activities in subjects with impaired glucose tolerance.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(2):237-43.
2007: Sarah Siggins; Igor Bykov; Martin Hermansson; Pentti Somerharju; Kai Lindros; Tatu A Miettinen; Matti Jauhiainen; Vesa M Olkkonen; Christian Ehnholm
Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.
Atherosclerosis 2007;190(1):114-23.
2006: Miriam Lee-Rueckert; Riikka Vikstedt; Jari Metso; Christian Ehnholm; Petri T Kovanen; Matti Jauhiainen
Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells.
Journal of lipid research 2006;47(8):1725-32.
2006: Vesa M Olkkonen; Marie Johansson; Monika Suchanek; Daoguang Yan; Riikka Hynynen; Christian Ehnholm; Matti Jauhiainen; Christoph Thiele; Markku Lehto
The OSBP-related proteins (ORPs): global sterol sensors for co-ordination of cellular lipid metabolism, membrane trafficking and signalling processes?
Biochemical Society transactions 2006;34(Pt 3):389-91.
2006: Jussi Naukkarinen; Christian Ehnholm; Leena Peltonen
Genetics of familial combined hyperlipidemia.
Current opinion in lipidology 2006;17(3):285-90.
2006: Henry J Pownall; Christian Ehnholm
The unique role of apolipoprotein A-I in HDL remodeling and metabolism.
Current opinion in lipidology 2006;17(3):209-13.
2006: Sarah Siggins; Christian Ehnholm; Matti Jauhiainen; Vesa M Olkkonen
Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(2):117-25.
2006: Hiroshi Watanabe; Sanni Söderlund; Aino Soro-Paavonen; Anne Hiukka; Eeva Leinonen; Corradina Alagona; Riitta Salonen; Tomi-Pekka Tuomainen; Christian Ehnholm; Matti Jauhiainen; Marja-Riitta Taskinen
Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):897-902.
2006: Juhani Kahri; Aino Soro-Paavonen; Christian Ehnholm; Marja-Riitta Taskinen
ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects.
Mediators of inflammation 2006;2006(3):12587.
2006: Aino Soro-Paavonen; Jukka Westerbacka; Christian Ehnholm; Marja-Riitta Taskinen
Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL.
Annals of medicine 2006;38(3):229-38.
2005: Riikka Hynynen; Saara Laitinen; Reijo Kakela; Kimmo Tanhuanpää; Sari Lusa / Löytökorpi; Christian Ehnholm; Pentti Somerharju; Elina Ikonen; Vesa M Olkkonen
Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis.
The Biochemical journal 2005;390(Pt 1):273-83.
2005: Sanni Söderlund; Aino Soro-Paavonen; Christian Ehnholm; Matti Jauhiainen; Marja-Riitta Taskinen
Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL.
Journal of lipid research 2005;46(8):1643-51.
2005: Matti Jauhiainen; Niko L Setälä; Christian Ehnholm; Jari Metso; Timo M T Tervo; Ove Eriksson; Juha M Holopainen
Phospholipid transfer protein is present in human tear fluid.
Biochemistry 2005;44(22):8111-6.
2005: Matti Jauhiainen; Christian Ehnholm
Determination of human plasma phospholipid transfer protein mass and activity.
Methods (San Diego, Calif.) 2005;36(2):97-101.
2005: Henry J Pownall; Christian Ehnholm
Enhancing reverse cholesterol transport: the case for phosphatidylcholine therapy.
Current opinion in lipidology 2005;16(3):265-8.
2005: Minna T Jänis; Jari Metso; Hilkka Lankinen; Tomas Strandin; Vesa M Olkkonen; Kerry-Anne Rye; Matti Jauhiainen; Christian Ehnholm
Apolipoprotein E activates the low-activity form of human phospholipid transfer protein.
Biochemical and biophysical research communications 2005;331(1):333-40.
2004: Minna T Jänis; Sarah Siggins; Esa Tahvanainen; Riikka Vikstedt; Kaisa Silander; Jari Metso; Arpo Aromaa; Marja-Riitta Taskinen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample.
Journal of lipid research 2004;45(12):2303-9.
2004: Tommi A Koivu; Toomas Uibu; Pekka Roto; Yue-Mei Fan; Saara Lehtinen; Hannu Jokela; Christian Ehnholm; Seppo T Nikkari; Terho Lehtimäki
Apolipoprotein E and A-IV polymorphisms in ethnic Russians living in Estonia.
Genetika 2004;40(9):1293-5.
2004: Tine Tholstrup; Christian Ehnholm; Matti Jauhiainen; Martin Petersen; Carl-Erik Høy; Pia Lund; Brittmarie Sandström
Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities.
The American journal of clinical nutrition 2004;79(4):564-9.
2004: Päivi Pajukanta; Heidi E Lilja; Janet S Sinsheimer; Rita M Cantor; Aldons J Lusis; Massimiliano Gentile; Xiaoqun Joyce Duan; Aino Soro-Paavonen; Jussi Naukkarinen; Janna Saarela; Markku Laakso; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
Nature genetics 2004;36(4):371-6.
2004: Sarah Siggins; Minna Kärkkäinen; Jukka Tenhunen; Jari Metso; Esa Tahvanainen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA.
Journal of lipid research 2004;45(2):387-95.
2003: Jean-François Mauger; Alice H Lichtenstein; Lynne M Ausman; Susan M Jalbert; Matti Jauhiainen; Christian Ehnholm; Benoît Lamarche
Effect of different forms of dietary hydrogenated fats on LDL particle size.
The American journal of clinical nutrition 2003;78(3):370-5.
2003: Sarah Siggins; Matti Jauhiainen; Vesa M Olkkonen; Jukka Tenhunen; Christian Ehnholm
PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma.
Journal of lipid research 2003;44(9):1698-704.
2003: Aino Soro; Matti Jauhiainen; Christian Ehnholm; Marja-Riitta Taskinen
Determinants of low HDL levels in familial combined hyperlipidemia.
Journal of lipid research 2003;44(8):1536-44.
2003: Catherine Desrumaux; Puiying A Mak; William A Boisvert; David Masson; Stupack Dwayne; Matti Jauhiainen; Christian Ehnholm; Linda K Curtiss
Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells.
Journal of lipid research 2003;44(8):1453-61.
2003: Marie Johansson; Virginie Bocher; Markku Lehto; Giulia Chinetti; Esa Kuismanen; Christian Ehnholm; Bart Staels; Vesa M Olkkonen
The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.
Molecular biology of the cell 2003;14(3):903-15.
2002: Nadia Haddy; Dirk De Bacquer; Marianne Mansour Chemaly; Mickaël Maurice; Christian Ehnholm; Alun Evans; Susanna Sans; Maria Do Carmo Martins; Guy De Backer; Gérard Siest; Sophie Visvikis
The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe.
European journal of human genetics : EJHG 2002;10(12):841-50.
2002: Terho Lehtimäki; Prasun Dastidar; Hannu Jokela; Timo Koivula; Saara Lehtinen; Christian Ehnholm; Reijo Punnonen
Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional apolipoprotein e genotype.
The Journal of clinical endocrinology and metabolism 2002;87(9):4147-53.
2002: Jari H Stengård; andrew clark; Kenneth M Weiss; Sharon L R Kardia; Deborah A Nickerson; Veikko Salomaa; Christian Ehnholm; Eric Boerwinkle; Charles F Sing
Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism.
American journal of human genetics 2002;71(3):501-17.
2002: Minna Kärkkäinen; Tomoichiro Oka; Vesa M Olkkonen; Jari Metso; Hiroaki Hattori; Matti Jauhiainen; Christian Ehnholm
Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).
The Journal of biological chemistry 2002;277(18):15413-8.
2002: Juha Vakkilainen; Matti Jauhiainen; Kati Ylitalo; Ilpo Nuotio; Jorma S A Viikari; Christian Ehnholm; Marja-Riitta Taskinen
LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins.
Journal of lipid research 2002;43(4):598-603.
2002: Alice H Lichtenstein; Lynne M Ausman; Susan M Jalbert; Montserrat Vilella-Bach; Matti Jauhiainen; Sandra McGladdery; Arja T Erkkilä; Christian Ehnholm; Jiri Frohlich; Ernst Schaefer
Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.
Journal of lipid research 2002;43(2):264-73.
2002: Saara Laitinen; Markku Lehto; Sanna Lehtonen; Kati Hyvärinen; Sanna Heino; Eero Lehtonen; Christian Ehnholm; Elina Ikonen; Vesa M Olkkonen
ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.
Journal of lipid research 2002;43(2):245-55.
2002: Veikko Salomaa; Vesa Rasi; Sangita Kulathinal; Elina Vahtera; Matti Jauhiainen; Christian Ehnholm; Juha Pekkanen
Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):353-8.
2001: C P J Maury; Mikko Liljeström; S Tiitinen; Kari Laiho; Kalevi Kaarela; Christian Ehnholm
Apolipoprotein E phenotypes in rheumatoid arthritis with or without amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(4):270-3.
2001: Jari H Stengård; Veikko Salomaa; Vesa Rasi; Elina Vahtera; Christian Ehnholm; Tom Krusius; M Perola; E Vartiainen
Utility of the Arg/Gln polymorphism of the factor VII (FVII) gene, serum lipid levels and body mass index in the prediction of the FVII:C and FVII:Ag in North Karelia; a cross-sectional and prospective study.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2001;12(6):445-52.
2001: Markku Lehto; Saara Laitinen; Giulia Chinetti; Marie Johansson; Christian Ehnholm; Bart Staels; Elina Ikonen; Vesa M Olkkonen
The OSBP-related protein family in humans.
Journal of lipid research 2001;42(8):1203-13.
2001: Katriina Aalto-Setälä; Kirsi Laitinen; Leena Erkkilä; Maija Leinonen; Matti Jauhiainen; Christian Ehnholm; M Tamminen; M Puolakkainen; I Penttilä; Pekka Saikku
Chlamydia pneumoniae does not increase atherosclerosis in the aortic root of apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):578-84.
2001: Alice H Lichtenstein; Matti Jauhiainen; S McGladdery; Lynne M Ausman; Susan M Jalbert; Montserrat Vilella-Bach; Christian Ehnholm; J Frohlich; Ernst Schaefer
Impact of hydrogenated fat on high density lipoprotein subfractions and metabolism.
Journal of lipid research 2001;42(4):597-604.
2001: Sonja Jaari; Ko Willems van Dijk; Vesa M Olkkonen; Anneke van Der Zee; Jari Metso; L Havekes; Matti Jauhiainen; Christian Ehnholm
Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;128(4):781-92.
2001: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
The impact of phospholipid transfer protein (PLTP) on HDL metabolism.
Atherosclerosis 2001;155(2):269-81.
2001: Mikko Syvänne; Pia Pajunen; Juhani Kahri; Sanni Lahdenperä; Christian Ehnholm; Markku S Nieminen; Marja-Riitta Taskinen
Determinants of the severity and extent of coronary artery disease in patients with type-2 diabetes and in nondiabetic subjects.
Coronary artery disease 2001;12(2):99-106.
2000: J Huuskonen; Vesa M Olkkonen; Christian Ehnholm; Jari Metso; I Julkunen; Matti Jauhiainen
Phospholipid transfer is a prerequisite for PLTP-mediated HDL conversion.
Biochemistry 2000;39(51):16092-8.
2000: Satu Vehkavaara; T Hakala-Ala-Pietilä; Antti Virkamäki; Robert Bergholm; Christian Ehnholm; Outi Hovatta; Marja-Riitta Taskinen; Hannele Yki-Järvinen
Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women.
Circulation 2000;102(22):2687-93.
2000: Dmitri Sviridov; LE Pyle; Matti Jauhiainen; Christian Ehnholm; NH Fidge
Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of prebeta-high density lipoprotein to alpha-high density lipoprotein.
Journal of lipid research 2000;41(11):1872-82.
2000: T Oka; Takeshi Kujiraoka; M Ito; Tohru Egashira; S Takahashi; M Nazeem Nanjee; Norman E Miller; Jari Metso; Vesa M Olkkonen; Christian Ehnholm; Matti Jauhiainen; H Hattori
Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive.
Journal of lipid research 2000;41(10):1651-7.
2000: Esa Tahvanainen; M Molin; S Vainio; L Tiret; V Nicaud; E Farinaro; L Masana; Christian Ehnholm
Intestinal fatty acid binding protein polymorphism at codon 54 is not associated with postprandial responses to fat and glucose tolerance tests in healthy young Europeans. Results from EARS II participants.
Atherosclerosis 2000;152(2):317-25.
2000: J Huuskonen; M Ekström; Esa Tahvanainen; A Vainio; Jari Metso; Pirkko J Pussinen; Christian Ehnholm; Vesa M Olkkonen; Matti Jauhiainen
Quantification of human plasma phospholipid transfer protein (PLTP): relationship between PLTP mass and phospholipid transfer activity.
Atherosclerosis 2000;151(2):451-61.
2000: Sanna Heino; Sari Lusa / Löytökorpi; Pentti Somerharju; Christian Ehnholm; Vesa M Olkkonen; Elina Ikonen
Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8375-80.
2000: J Huuskonen; Christian Ehnholm
Phospholipid transfer protein in lipid metabolism.
Current opinion in lipidology 2000;11(3):285-9.
1999: Saara Laitinen; Vesa M Olkkonen; Christian Ehnholm; Elina Ikonen
Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism.
Journal of lipid research 1999;40(12):2204-11.
1999: Jari H Stengård; Sharon L R Kardia; M Tervahauta; Christian Ehnholm; A Nissinen; Charles F Sing
Utility of the predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men aged 65 to 84 years is dependent on context defined by Apo E genotype and area of residence.
Clinical genetics 1999;56(5):367-77.
1999: Esa Tahvanainen; Matti Jauhiainen; H Funke; E Vartiainen; J Sundvall; Christian Ehnholm
Serum phospholipid transfer protein activity and genetic variation of the PLTP gene.
Atherosclerosis 1999;146(1):107-15.
1999: J Huuskonen; Gerd Wohlfahrt; Matti Jauhiainen; Christian Ehnholm; O Teleman; Vesa M Olkkonen
Structure and phospholipid transfer activity of human PLTP: analysis by molecular modeling and site-directed mutagenesis.
Journal of lipid research 1999;40(6):1123-30.
1999: Päivi Pajukanta; Joseph D Terwilliger; Markus Perola; Tero Hiekkalinna; Ilpo Nuotio; Pekka Ellonen; Maija Parkkonen; Jaana Hartiala; Kati Ylitalo; Jussi Pihlajamäki; Kimmo Porkka; Markku Laakso; Jorma Viikari; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
American journal of human genetics 1999;64(5):1453-63.
1999: Matti Jauhiainen; J Huuskonen; M Baumann; Jari Metso; T Oka; Tohru Egashira; H Hattori; Vesa M Olkkonen; Christian Ehnholm
Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I.
Journal of lipid research 1999;40(4):654-64.
1998: Mikko Syvänne; Markku S Nieminen; M Heikki Frick; Heikki Kauma; Silja Majahalme; Vesa Virtanen; Y Antero Kesäniemi; Amos Pasternack; Christian Ehnholm; Marja-Riitta Taskinen
Associations between lipoproteins and the progression of coronary and vein-graft atherosclerosis in a controlled trial with gemfibrozil in men with low baseline levels of HDL cholesterol.
Circulation 1998;98(19):1993-9.
1998: Esa Tahvanainen; Päivi Pajukanta; Kimmo Porkka; S Nieminen; L Ikävalko; Ilpo Nuotio; Marja-Riitta Taskinen; L Peltonen; Christian Ehnholm
Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(11):1810-7.
1998: J Huuskonen; Matti Jauhiainen; Christian Ehnholm; Vesa M Olkkonen
Biosynthesis and secretion of human plasma phospholipid transfer protein.
Journal of lipid research 1998;39(10):2021-30.
1998: Terho Lehtimäki; Toomas Uibu; Pekka Roto; Timo Koivula; Hannu Jokela; Christian Ehnholm; N Peltonen; Tapio Nikkari
Apolipoprotein E and A-IV polymorphisms in the Estonian population.
Clinical genetics 1998;54(1):106-7.
1998: Sonja Jaari; Ko Willems van Dijk; B van 't Hof; Anneke van Der Zee; Vesa M Olkkonen; Matti Jauhiainen; Marten H Hofker; L Havekes; Christian Ehnholm
Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice.
Journal of lipid research 1998;39(6):1248-53.
1998: Veikko Salomaa; Vesa Rasi; Jari H Stengård; Elina Vahtera; Juha Pekkanen; E Vartiainen; Christian Ehnholm; P Puska
Intra- and interindividual variability of hemostatic factors and traditional cardiovascular risk factors in a three-year follow-up.
Thrombosis and haemostasis 1998;79(5):969-74.
1998: Saara Lehtinen; P Luoma; Simo Näyhä; Juhani Hassi; Christian Ehnholm; Tapio Nikkari; N Peltonen; Hannu Jokela; Timo Koivula; Terho Lehtimäki
Apolipoprotein A-IV polymorphism in Saami and Finns: frequency and effect on serum lipid levels.
Annals of medicine 1998;30(2):218-23.
1998: Päivi Pajukanta; Ilpo Nuotio; Joseph D Terwilliger; Kimmo Porkka; Kati Ylitalo; Jussi Pihlajamäki; Anu Suomalainen; Ann-Christine Syvänen; T Lehtimäki; Jorma S A Viikari; Markku Laakso; Marja-Riitta Taskinen; Christian Ehnholm; Leena Peltonen
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Nature genetics 1998;18(4):369-73.
1998: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; T Sareneva; Pentti Somerharju; Christian Ehnholm
Oxidative modification of HDL3 in vitro and its effect on PLTP-mediated phospholipid transfer.
Biochimica et biophysica acta 1998;1391(2):181-92.
1998: Esa Tahvanainen; M Syvanne; M Heikki Frick; S Murtomaki-Repo; Marjatta Antikainen; Y A Kesaniemi; Heikki Kauma; A Pasternak; Marja-Riitta Taskinen; Christian Ehnholm
Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Invsestigators.
The Journal of clinical investigation 1998;101(5):956-60.
1998: Juha Vakkilainen; Kimmo Porkka; Ilpo Nuotio; Päivi Pajukanta; L Suurinkeroinen; Kati Ylitalo; Jorma S A Viikari; Christian Ehnholm; Marja-Riitta Taskinen
Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group.
European journal of clinical investigation 1998;28(1):24-32.
1998: Pirkko J Pussinen; Matti Jauhiainen; Jari Metso; LE Pyle; Y L Marcel; NH Fidge; Christian Ehnholm
Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I.
Journal of lipid research 1998;39(1):152-61.
1997: Petteri Knudsen; S Murtomäki; Marjatta Antikainen; Sonja Jaari; Sanni Lahdenperä; Christian Ehnholm; Marja-Riitta Taskinen
The Asn-291-->Ser and Ser-477-->Stop mutations of the lipoprotein lipase gene and their significance for lipid metabolism in patients with hypertriglyceridaemia.
European journal of clinical investigation 1997;27(11):928-35.
1997: S Murtomäki; Esa Tahvanainen; Marjatta Antikainen; L Tiret; V Nicaud; H Jansen; Christian Ehnholm
Hepatic lipase gene polymorphisms influence plasma HDL levels. Results from Finnish EARS participants. European Atherosclerosis Research Study.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(10):1879-84.
1997: Kimmo Porkka; Ilpo Nuotio; Päivi Pajukanta; Christian Ehnholm; L Suurinkeroinen; Mikko Syvänne; Terho Lehtimäki; Anne-Tiina Lahdenkari; Sanni Lahdenperä; Kati Ylitalo; Marjatta Antikainen; Markus Perola; Olli T Raitakari; Petri T Kovanen; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Phenotype expression in familial combined hyperlipidemia.
Atherosclerosis 1997;133(2):245-53.
1997: Terho Lehtimäki; H Frankberg-Lakkala; Tiina Solakivi; Anna-Maija Koivisto; P Laippala; Christian Ehnholm; Hannu Jokela; Timo Koivula; Tapio Nikkari
The effect of short-term fasting, apolipoprotein E gene polymorphism, and sex on plasma lipids.
The American journal of clinical nutrition 1997;66(3):599-605.
1997: P Marques-Vidal; Matti Jauhiainen; Jari Metso; Christian Ehnholm
Transformation of high density lipoprotein 2 particles by hepatic lipase and phospholipid transfer protein.
Atherosclerosis 1997;133(1):87-95.
1997: Pirkko J Pussinen; Vesa M Olkkonen; Matti Jauhiainen; Christian Ehnholm
Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein.
Journal of lipid research 1997;38(7):1473-81.
1997: Päivi Pajukanta; Kimmo Porkka; Marjatta Antikainen; Marja-Riitta Taskinen; Markus Perola; S Murtomäki-Repo; Sonja Jaari; Ilpo Nuotio; L Suurinkeroinen; Anne-Tiina Lahdenkari; Ann-Christine Syvänen; Jorma S A Viikari; Christian Ehnholm; Leena Peltonen
No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(5):841-50.
1997: Kati Ylitalo; Kimmo Porkka; Seppo Meri; Ilpo Nuotio; L Suurinkeroinen; Juha Vakkilainen; Päivi Pajukanta; Jorma S A Viikari; Leena Peltonen; Christian Ehnholm; Marja-Riitta Taskinen
Serum complement and familial combined hyperlipidemia.
Atherosclerosis 1997;129(2):271-7.
1997: Marju Tilly-Kiesi; C J Packard; Juhani Kahri; Christian Ehnholm; J Shepherd; Marja-Riitta Taskinen
In vivo metabolism of apo A-I and apo A-II in subjects with apo A-I(Lys107-->0) associated with reduced HDL cholesterol and Lp(AI w AII) deficiency.
Atherosclerosis 1997;128(2):213-22.
1997: Petteri Knudsen; Marjatta Antikainen; Mikko Uusi-Oukari; Sonja Jaari; Sanni Lahdenperä; A Bensadoun; Harald Funke; Heiko Wiebusch; Gerd Assmann; Marja-Riitta Taskinen; Christian Ehnholm
Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene.
Atherosclerosis 1997;128(2):165-74.
1997: Pirkko J Pussinen; Matti Jauhiainen; Christian Ehnholm
ApoA-II/apoA-I molar ratio in the HDL particle influences phospholipid transfer protein-mediated HDL interconversion.
Journal of lipid research 1997;38(1):12-21.
1996: Mikko Syvänne; Graciela Castro; C Dengremont; C De Geitere; Matti Jauhiainen; Christian Ehnholm; S Michelagnoli; G Franceschini; Juhani Kahri; Marja-Riitta Taskinen
Cholesterol efflux from Fu5AH hepatoma cells induced by plasma of subjects with or without coronary artery disease and non-insulin-dependent diabetes: importance of LpA-I:A-II particles and phospholipid transfer protein.
Atherosclerosis 1996;127(2):245-53.
1996: Tiina Saarto; Carl Blomqvist; Christian Ehnholm; Marja-Riitta Taskinen; Inkeri Elomaa
Effects of chemotherapy-induced castration on serum lipids and apoproteins in premenopausal women with node-positive breast cancer.
The Journal of clinical endocrinology and metabolism 1996;81(12):4453-7.
1996: J Huuskonen; Vesa M Olkkonen; Matti Jauhiainen; Jari Metso; Pentti Somerharju; Christian Ehnholm
Acyl chain and headgroup specificity of human plasma phospholipid transfer protein.
Biochimica et biophysica acta 1996;1303(3):207-14.
1996: Marja-Riitta Taskinen; J Puolakka; T Pyörälä; H Luotola; M Bjäörn; J Kääriänen; Sanni Lahdenperä; Christian Ehnholm
Hormone replacement therapy lowers plasma Lp(a) concentrations. Comparison of cyclic transdermal and continuous estrogen-progestin regimens.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(10):1215-21.
1996: Marjatta Antikainen; S Murtomäki; Mikko Syvänne; R Pahlman; Esa Tahvanainen; Matti Jauhiainen; M H Frick; Christian Ehnholm
The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.
The Journal of clinical investigation 1996;98(4):883-5.
1996: Mikko Uusi-Oukari; Christian Ehnholm; Matti Jauhiainen
Inhibition of hepatic lipase by m-aminophenylboronate. Application of phenylboronate affinity chromatography for purification of human postheparin plasma lipases.
Journal of chromatography. B, Biomedical applications 1996;682(2):233-42.
1996: Marjatta Antikainen; L Suurinkeroinen; Matti Jauhiainen; Christian Ehnholm; Marja-Riitta Taskinen
Development and evaluation of an ELISA method for the determination of lipoprotein lipase mass concentration--comparison with a commercial, one-step enzyme immunoassay.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1996;34(7):547-53.
1996: Arnold von Eckardstein; Matti Jauhiainen; Y Huang; Jari Metso; Claus Langer; Pirkko J Pussinen; S Wu; Christian Ehnholm; Gerd Assmann
Phospholipid transfer protein mediated conversion of high density lipoproteins generates pre beta 1-HDL.
Biochimica et biophysica acta 1996;1301(3):255-62.
1996: Kimmo Porkka; Christian Ehnholm
Smoking, alcohol and lipoprotein metabolism.
Current opinion in lipidology 1996;7(3):162-6.
1996: Marjatta Antikainen; H Tenkanen; Marja-Riitta Taskinen; Christian Ehnholm
Mutations affecting human lipoprotein lipase gene.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():59-61.
1996: Jari H Stengård; J Pekkanen; Christian Ehnholm; A Nissinen; Charles F Sing
Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men.
Human genetics 1996;97(5):677-84.
1996: A Lamberg; Matti Jauhiainen; Jari Metso; Christian Ehnholm; C Shoulders; J Scott; Taina Pihlajaniemi; Kari I Kivirikko
The role of protein disulphide isomerase in the microsomal triacylglycerol transfer protein does not reside in its isomerase activity.
The Biochemical journal 1996;315 ( Pt 2)():533-6.
1996: Timo E Strandberg; Reijo S Tilvis; O Lindberg; Jaakko Valvanne; Sirpa Sairanen; Christian Ehnholm; Jaakko Tuomilehto
High plasma insulin is associated with lower LDL cholesterol in elderly individuals.
Atherosclerosis 1996;121(2):267-73.
1996: Kimmo Kontula; Christian Ehnholm
Regulatory mutations in human lipoprotein disorders and atherosclerosis.
Current opinion in lipidology 1996;7(2):64-8.
1996: Petteri Knudsen; Marjatta Antikainen; Sonja Jaari; Mikko Uusi-Oukari; H Tenkanen; Sanni Lahdenperä; Juhani Kahri; Marju Tilly-Kiesi; A Bensadoun; Marja-Riitta Taskinen; Christian Ehnholm
A compound heterozygote for hepatic lipase gene mutations Leu334-->Phe and Thr383-->Met: correlation between hepatic lipase activity and phenotypic expression.
Journal of lipid research 1996;37(4):825-34.
1996: Mikko Syvänne; Marjatta Antikainen; Sonja Jaari; H Tenkanen; Sanni Lahdenperä; Christian Ehnholm; Marja-Riitta Taskinen
Heterozygosity for Asn291-->Ser mutation in the lipoprotein lipase gene in two Finnish pedigrees: effect of hyperinsulinemia on the expression of hypertriglyceridemia.
Journal of lipid research 1996;37(4):727-38.
1996: Taina Routi; Tapani Rönnemaa; Pia Salo; Ritva Seppänen; J Marniemi; J Viikari; Christian Ehnholm; Olli Simell
Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo.
The American journal of clinical nutrition 1996;63(3):386-91.
1996: Tiina Saarto; Carl Blomqvist; Christian Ehnholm; Marja-Riitta Taskinen; Inkeri Elomaa
Antiatherogenic effects of adjuvant antiestrogens: a randomized trial comparing the effects of tamoxifen and toremifene on plasma lipid levels in postmenopausal women with node-positive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(2):429-33.
1996: Sari Lusa / Löytökorpi; Matti Jauhiainen; Jari Metso; Pentti Somerharju; Christian Ehnholm
The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion.
The Biochemical journal 1996;313 ( Pt 1)():275-82.
1995: Veikko Salomaa; Vesa Rasi; J Pekkanen; Elina Vahtera; Matti Jauhiainen; E Vartiainen; Christian Ehnholm; J Tuomilehto; G Myllylä
Association of hormone replacement therapy with hemostatic and other cardiovascular risk factors. The FINRISK Hemostasis Study.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1549-55.
1995: Marju Tilly-Kiesi; Q Zhang; Sonja Jaari; Juhani Kahri; Sanni Lahdenperä; Christian Ehnholm; Marja-Riitta Taskinen
ApoA-IHelsinki (Lys107-->0) associated with reduced HDL cholesterol and LpA-I:A-II deficiency.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(9):1294-306.
1995: Pirkko J Pussinen; M Jauhianinen; Jari Metso; J Tyynelä; Christian Ehnholm
Pig plasma phospholipid transfer protein facilitates HDL interconversion.
Journal of lipid research 1995;36(5):975-85.
1995: Tuomo Kuusi; Hannele Yki-Järvinen; R Kauppinen-Mäkelin; Matti Jauhiainen; Christian Ehnholm; M Kauppila; P Seppälä; J Viikari; Erkki Kujansuu; S Rajala
Effect of insulin treatment on serum lipoprotein(a) in non-insulin-dependent diabetes.
European journal of clinical investigation 1995;25(3):194-200.
1995: Jari H Stengård; K E Zerba; J Pekkanen; Christian Ehnholm; A Nissinen; Charles F Sing
Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men.
Circulation 1995;91(2):265-9.
1994: Matti Mänttäri; Vesa Manninen; J K Huttunen; T Palosuo; Christian Ehnholm; OP Heinonen; M Heikki Frick
Serum ferritin and ceruloplasmin as coronary risk factors.
European heart journal 1994;15(12):1599-603.
1994: M Pursiainen; Matti Jauhiainen; Christian Ehnholm
Low-density lipoprotein activates the protease region of recombinant apo(a).
Biochimica et biophysica acta 1994;1215(1-2):170-5.
1994: Veikko Salomaa; Vesa Rasi; J Pekkanen; Elina Vahtera; Matti Jauhiainen; Erkki Vartiainen; G Myllylä; Christian Ehnholm
Haemostatic factors and prevalent coronary heart disease; the FINRISK Haemostasis Study.
European heart journal 1994;15(10):1293-9.
1994: Veikko Salomaa; Vesa Rasi; Elina Vahtera; J Pekkanen; M Pursiainen; Matti Jauhiainen; Erkki Vartiainen; Christian Ehnholm; G Myllylä
Haemostatic factors and lipoprotein (a) in three geographical areas in Finland: the Finrisk Haemostasis Study.
Journal of cardiovascular risk 1994;1(3):241-8.
1994: Christian Ehnholm; H Tenkanen; P de Knijff; L Havekes; M Rosseneu; H J Menzel; L Tiret
Genetic polymorphism of apolipoprotein A-IV in five different regions of Europe. Relations to plasma lipoproteins and to history of myocardial infarction: the EARS study. European Atherosclerosis Research Study.
Atherosclerosis 1994;107(2):229-38.
1994: H Tenkanen; Marja-Riitta Taskinen; Marjatta Antikainen; I Ulmanen; K Kontula; Christian Ehnholm
A novel amino acid substitution (His183-->Gln) in exon 5 of the lipoprotein lipase gene results in loss of catalytic activity: phenotypic expression of the mutant gene in a heterozygous state.
Journal of lipid research 1994;35(2):220-8.
1994: M Pursiainen; Matti Jauhiainen; Petri Kovanen; Christian Ehnholm
Proteolytic degradation of low-density lipoprotein by lipoprotein(a) and by recombinant apo(a).
Chemistry and physics of lipids 1994;67-68():25-33.
1994: K Kervinen; Markku Savolainen; J Salokannel; A Hynninen; J Heikkinen; Christian Ehnholm; M Juhani Koistinen; Y Antero Kesäniemi
Apolipoprotein E and B polymorphisms--longevity factors assessed in nonagenarians.
Atherosclerosis 1994;105(1):89-95.
1993: H T Vanhanen; S Blomqvist; Christian Ehnholm; M Hyvönen; Matti Jauhiainen; I Torstila; Tatu A Miettinen
Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment.
Journal of lipid research 1993;34(9):1535-44.
1993: M Välimäki; Juhani Kahri; Kalevi Laitinen; Sanni Lahdenperä; Tuomo Kuusi; Christian Ehnholm; Matti Jauhiainen; J M Bard; J C Fruchart; Marja-Riitta Taskinen
High density lipoprotein subfractions, apolipoprotein A-I containing lipoproteins, lipoprotein (a), and cholesterol ester transfer protein activity in alcoholic women before and after ethanol withdrawal.
European journal of clinical investigation 1993;23(7):406-17.
1993: Matti Jauhiainen; Jari Metso; R Pahlman; S Blomqvist; Arie Van Tol; Christian Ehnholm
Human plasma phospholipid transfer protein causes high density lipoprotein conversion.
The Journal of biological chemistry 1993;268(6):4032-6.
1992: H Tenkanen; Christian Ehnholm
Molecular basis for apo A-IV polymorphisms.
Annals of medicine 1992;24(5):369-74.
1992: Antti Sajantila; B Budowle; M Ström; V Johnsson; M Lukka; Leena Peltonen; Christian Ehnholm
PCR amplification of alleles at the DIS80 locus: comparison of a Finnish and a North American Caucasian population sample, and forensic casework evaluation.
American journal of human genetics 1992;50(4):816-25.
1992: P Helminen; Antti Sajantila; V Johnsson; M Lukka; Christian Ehnholm; Leena Peltonen
Amplification of three hypervariable DNA regions by polymerase chain reaction for paternity determinations: comparison with conventional methods and DNA fingerprinting.
Molecular and cellular probes 1992;6(1):21-6.
1992: Antti Sajantila; K Makkonen; Christian Ehnholm; Leena Peltonen
DNA profiling in a genetically isolated population using three hypervariable DNA markers.
Human heredity 1992;42(6):372-9.
1992: Antti Sajantila; S Puomilahti; V Johnsson; Christian Ehnholm
Amplification of reproducible allele markers for amplified fragment length polymorphism analysis.
BioTechniques 1992;12(1):16, 18, 20-2.
1992: Markku S Nieminen; K J Mattila; K Aalto-Setälä; Tuomo Kuusi; Kimmo Kontula; R Kauppinen-Mäkelin; Christian Ehnholm; Matti Jauhiainen; M Valle; Marja-Riitta Taskinen
Lipoproteins and their genetic variation in subjects with and without angiographically verified coronary artery disease.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(1):58-69.
1991: Christian Ehnholm; S E Bozas; H Tenkanen; L Kirszbaum; Jari Metso; B Murphy; ID Walker
The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I.
Biochimica et biophysica acta 1991;1086(3):255-60.
1991: J P Ojala; E Helve; Christian Ehnholm; K Aalto-Setälä; Kimmo Kontula; Matti J Tikkanen
Effect of apolipoprotein E polymorphism and XbaI polymorphism of apolipoprotein B on response to lovastatin treatment in familial and non-familial hypercholesterolaemia.
Journal of internal medicine 1991;230(5):397-405.
1991: M Välimäki; Kalevi Laitinen; R Ylikahri; Christian Ehnholm; Matti Jauhiainen; J M Bard; J C Fruchart; Marja-Riitta Taskinen
The effect of moderate alcohol intake on serum apolipoprotein A-I-containing lipoproteins and lipoprotein (a).
Metabolism: clinical and experimental 1991;40(11):1168-72.
1991: P Helminen; V Johnsson; Christian Ehnholm; Leena Peltonen
Proving paternity of children with deceased fathers.
Human genetics 1991;87(6):657-60.
1991: H Tenkanen; P Koshinen; Kimmo Kontula; K Aalto-Setälä; Matti Mänttäri; Vesa Manninen; S L Runeberg; M R Taskinen; Christian Ehnholm
Polymorphisms of the gene encoding cholesterol ester transfer protein and serum lipoprotein levels in subjects with and without coronary heart disease.
Human genetics 1991;87(5):574-8.
1991: H Tenkanen; M Lukka; Matti Jauhiainen; Jari Metso; M Baumann; Leena Peltonen; Christian Ehnholm
The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):851-6.
1991: Matti Jauhiainen; P Koskinen; Christian Ehnholm; M H Frick; Matti Mänttäri; Vesa Manninen; J K Huttunen
Lipoprotein (a) and coronary heart disease risk: a nested case-control study of the Helsinki Heart Study participants.
Atherosclerosis 1991;89(1):59-67.
1991: Matti Jauhiainen; Jari Metso; P Koskinen; Christian Ehnholm
Characterization of the enzyme activity of human plasma lipoprotein (a) using synthetic peptide substrates.
The Biochemical journal 1991;274 ( Pt 2)():491-6.
1991: Matti Mänttäri; Petri Koskinen; Christian Ehnholm; J K Huttunen; Vesa Manninen
Apolipoprotein E polymorphism influences the serum cholesterol response to dietary intervention.
Metabolism: clinical and experimental 1991;40(2):217-21.
1991: Antti Sajantila; M Ström; B Budowle; Pentti J Tienari; Christian Ehnholm; Leena Peltonen
The distribution of the HLA-DQ alpha alleles and genotypes in the Finnish population as determined by the use of DNA amplification and allele specific oligonucleotides.
International journal of legal medicine 1991;104(4):181-4.
1990: Christian Ehnholm; Matti Jauhiainen; Jari Metso
Interaction of lipoprotein(a) with fibronectin and its potential role in atherogenesis.
European heart journal 1990;11 Suppl E():190-5.
1990: Alpo F Vuorio; Antti Sajantila; T Hämäläinen; Ann-Christine Syvänen; Christian Ehnholm; L Peltonen
Amplification of the hypervariable region close to the apolipoprotein B gene: application to forensic problems.
Biochemical and biophysical research communications 1990;170(2):616-20.
1990: Päivi Heikkilä; AI Kahri; Petri Kovanen; Christian Ehnholm
Effects of mevinolin, an inhibitor of cholesterol synthesis, on the morphology and function of differentiating and differentiated rat adrenocortical cells in primary culture.
Cell and tissue research 1990;261(1):125-32.
1990: M J Tikkanen; J K Huttunen; Christian Ehnholm; P Pietinen
Apolipoprotein E4 homozygosity predisposes to serum cholesterol elevation during high fat diet.
Arteriosclerosis (Dallas, Tex.) 1990;10(2):285-8.
1989: E M Salonen; Matti Jauhiainen; Luciano Zardi; Antti Vaheri; Christian Ehnholm
Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.
The EMBO journal 1989;8(13):4035-40.
1989: AI Kahri; Päivi Heikkilä; Christian Ehnholm; H Ranki; Petri Kovanen
Sequential expression of high and low density lipoprotein receptors in differentiating fetal rat adrenocortical cells in primary culture.
Endocrinology 1989;125(1):68-75.
1989: Päivi Heikkilä; AI Kahri; Christian Ehnholm; Petri Kovanen
The effect of low- and high-density lipoprotein cholesterol on steroid hormone production and ACTH-induced differentiation of rat adrenocortical cells in primary culture.
Cell and tissue research 1989;256(3):487-94.
1989: Tuomo Kuusi; M S Nieminen; Christian Ehnholm; Hannele Yki-Järvinen; M Valle; E A Nikkilä; Marja-Riitta Taskinen
Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients.
Arteriosclerosis (Dallas, Tex.) 1989;9(2):237-41.
1988: C P J Maury; K J Tötterman; C G Gref; Christian Ehnholm
Serum amyloid A protein, apolipoprotein A-I, and apolipoprotein B during the course of acute myocardial infarction.
Journal of clinical pathology 1988;41(12):1263-8.
1988: Päivi Heikkilä; AI Kahri; Christian Ehnholm; Petri Kovanen
Endogenous cholesterol synthesis is sufficient for ACTH-induced differentiation of rat adrenocortical cells in primary culture.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(9):936-42.
1988: Jaakko Tuomilehto; Marja Silvasti; A Aro; A Koistinen; P Karttunen; C G Gref; Christian Ehnholm; M Uusitupa
Long term treatment of severe hypercholesterolaemia with guar gum.
Atherosclerosis 1988;72(2-3):157-62.
1988: P Helminen; Christian Ehnholm; M L Lokki; A Jeffreys; Leena Peltonen
Application of DNA "fingerprints" to paternity determinations.
Lancet 1988;1(8585):574-6.
1988: M Lukka; Jari Metso; Christian Ehnholm
Apolipoprotein A-IV polymorphism in the Finnish population: gene frequencies and description of a rare allele.
Human heredity 1988;38(6):359-62.
1987: Y A Kesäniemi; Christian Ehnholm; Tatu A Miettinen
Multicentric reticulohistiocytosis, another lipid disorder with normolipidemic xanthomatosis?
Atherosclerosis 1987;68(3):179-89.
1986: Christian Ehnholm; M Lukka; I Rostedt; K Harper
Monoclonal antibodies specific for different regions of human apolipoprotein A-I. Characterization of an antibody that does not bind to a genetic variant of apoA-I (Glu----136 Lys).
Journal of lipid research 1986;27(12):1259-64.