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Sabine Ehrt

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TOP 3
Jennifer L Small; Oleg V Tsodikov; Omar Vandal; Eva C Boritsch; Charles S Craik; Giselle M Knudsen; Anthony J O'Donoghue; Sabine Ehrt
Substrate Specificity of MarP, a Periplasmic Protease Required for Resistance to Acid and Oxidative Stress in Mycobacterium tuberculosis.
Joeli Marrero; Kyu Y Rhee; Carolina Trujillo; Sabine Ehrt
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
Brian D Robertson; Eric Rubin; Dirk Schnappinger; David Sherman; Jelle Thole; Paul van Helden; Omar Vandal; Gerhard Walzl; Digby Warner; Robert Wilkinson; Thomas Dick; Danny Altmann; Clif Barry; Bill Bishai; Stewart Cole; Ken Duncan; Chris Dye; Sabine Ehrt; Hanif Esmail; Joanne Flynn; Richard Hafner; Gray Handley; Willem Hanekom; Gilla Kaplan; Stefan H E Kaufmann; Peter Kim; Christian Lienhardt; Valerie Mizrahi; Douglas Young
Detection and treatment of subclinical tuberculosis.

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All Publications

2013: Jennifer L Small; Oleg V Tsodikov; Omar Vandal; Eva C Boritsch; Charles S Craik; Giselle M Knudsen; Anthony J O'Donoghue; Sabine Ehrt
Substrate Specificity of MarP, a Periplasmic Protease Required for Resistance to Acid and Oxidative Stress in Mycobacterium tuberculosis.
The Journal of biological chemistry 2013;288(18):12489-99.
2013: Joeli Marrero; Kyu Y Rhee; Carolina Trujillo; Sabine Ehrt
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
PLoS pathogens 2013;9(1):e1003116.
2012: Brian D Robertson; Eric Rubin; Dirk Schnappinger; David Sherman; Jelle Thole; Paul van Helden; Omar Vandal; Gerhard Walzl; Digby Warner; Robert Wilkinson; Thomas Dick; Danny Altmann; Clif Barry; Bill Bishai; Stewart Cole; Ken Duncan; Chris Dye; Sabine Ehrt; Hanif Esmail; Joanne Flynn; Richard Hafner; Gray Handley; Willem Hanekom; Gilla Kaplan; Stefan H E Kaufmann; Peter Kim; Christian Lienhardt; Valerie Mizrahi; Douglas Young
Detection and treatment of subclinical tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2012;92(6):447-52.
2012: Antje Blumenthal; Warwick J Britton; Sabine Ehrt; Gilles J Guillemin; Jennifer H Huch; Gayathri Nagalingam; George A Smythe; Lara Walker; Bernadette M Saunders
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
PloS one 2012;7(5):e37314.
2011: Maria de la Paz Santangelo; Sabine Ehrt; Petra M Gest; Mercedes Gonzalez-Juarrero; Marcelo E Guerin; Mathieu Coinçon; Racha Daher; Anne J Lenaerts; Ha Pham; Susan E Puckett; Gavin Ryan; Dirk Schnappinger; John S Spencer; Jurgen Sygusch; Michel Therisod; Mary Jackson
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
The Journal of biological chemistry 2011;286(46):40219-31.
2011: Sae Woong Park; Daniel J Wilson; Courtney C Aldrich; Clifton E Barry; Antje Blumenthal; Helena I Boshoff; Sabine Ehrt; HyungJin Eoh; Marcus Klotzsche; Ujjini Manjunatha; Kyu Rhee; Dirk Schnappinger
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
PLoS pathogens 2011;7(9):e1002264.
2011: Crystal M Darby; Sabine Ehrt; Aditya Venugopal; Carl F Nathan
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.
Tuberculosis (Edinburgh, Scotland) 2011;91(5):343-7.
2011: Kyu Y Rhee; Dirk Schnappinger; Aditya Venugopal; Luiz Pedro Carvalho; Ruslana Bryk; Sabine Ehrt; Joeli Marrero; Sae Woong Park; Carl Nathan
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
Trends in microbiology 2011;19(7):307-14.
2011: Aditya Venugopal; Ruslana Bryk; Shuangping Shi; Kyu Rhee; Poonam Rath; Dirk Schnappinger; Sabine Ehrt; Carl Nathan
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Cell host & microbe 2011;9(1):21-31.
2010: Luiz Pedro Carvalho; Steven M Fischer; Joeli Marrero; Carl Nathan; Sabine Ehrt; Kyu Y Rhee
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
Chemistry & biology 2010;17(10):1122-31.
2010: Tapan Biswas; Jennifer Small; Omar Vandal; Toshiko Odaira; Haiteng Deng; Sabine Ehrt; Oleg V Tsodikov
Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure (London, England : 1993) 2010;18(10):1353-63.
2010: Joeli Marrero; Kyu Y Rhee; Dirk Schnappinger; Kevin Pethe; Sabine Ehrt
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9819-24.
2010: Antje Blumenthal; Carolina Trujillo; Sabine Ehrt; Dirk Schnappinger
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.
PloS one 2010;5(12):e15667.
2010: Sheetal Gandotra; Maria B Lebron; Sabine Ehrt
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.
PLoS pathogens 2010;6(8):e1001040.
2009: Sabine Ehrt; Dirk Schnappinger
Mycobacterial survival strategies in the phagosome: defence against host stresses.
Cellular microbiology 2009;11(8):1170-8.
2009: Marcus Klotzsche; Sabine Ehrt; Dirk Schnappinger
Improved tetracycline repressors for gene silencing in mycobacteria.
Nucleic acids research 2009;37(6):1778-88.
2009: Antje Blumenthal; Toshihiko Kobayashi; Lynda M Pierini; Niaz Banaei; Joel D Ernst; Kensuke Miyake; Sabine Ehrt
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.
Cell host & microbe 2009;5(1):35-46.
2009: Omar H Vandal; Julia A Roberts; Toshiko Odaira; Dirk Schnappinger; Carl F Nathan; Sabine Ehrt
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
Journal of bacteriology 2009;191(2):625-31.
2008: Sabine Ehrt
Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam.
The Journal of experimental medicine 2008;205(10):2184-5.
2008: Omar H Vandal; Lynda M Pierini; Dirk Schnappinger; Carl F Nathan; Sabine Ehrt
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
Nature medicine 2008;14(8):849-54.
2008: Ruslana Bryk; Benjamin Gold; Aditya Venugopal; Jasbir Singh; Raghu Samy; Krzysztof Pupek; Hua Cao; Carmen Popescu; Mark Gurney; Srinivas Hotha; Joseph Cherian; Kyu Rhee; Lan Ly; Paul J Converse; Sabine Ehrt; Omar Vandal; Xiuju Jiang; Jean Schneider; Gang Lin; Carl Nathan
Selective killing of nonreplicating mycobacteria.
Cell host & microbe 2008;3(3):137-45.
2007: Sheetal Gandotra; Dirk Schnappinger; Mercedes Monteleone; Wolfgang Hillen; Sabine Ehrt
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.
Nature medicine 2007;13(12):1515-20.
2007: Sheetal Gandotra; Sihyug Jang; Peter J Murray; Padmini Salgame; Sabine Ehrt
Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis.
Infection and immunity 2007;75(11):5127-34.
2007: Nicolas C Stephanou; Feng Gao; Paola Bongiorno; Sabine Ehrt; Dirk Schnappinger; Stewart Shuman; Michael S Glickman
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks.
Journal of bacteriology 2007;189(14):5237-46.
2007: Xinzheng V Guo; Mercedes Monteleone; Marcus Klotzsche; Annette Kamionka; Wolfgang Hillen; Miriam Braunstein; Sabine Ehrt; Dirk Schnappinger
Silencing Mycobacterium smegmatis by using tetracycline repressors.
Journal of bacteriology 2007;189(13):4614-23.
2007: Sabine Ehrt; Dirk Schnappinger
Mycobacterium tuberculosis virulence: lipids inside and out.
Nature medicine 2007;13(3):284-5.
2006: Sabine Ehrt; Dirk Schnappinger
Controlling gene expression in mycobacteria.
Future microbiology 2006;1(2):177-84.
2006: Dirk Schnappinger; Sabine Ehrt
Introduction: genomic approaches in infectious diseases.
Microbes and infection / Institut Pasteur 2006;8(6):1611-2.
2006: Dirk Schnappinger; Gary K Schoolnik; Sabine Ehrt
Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another.
Microbes and infection / Institut Pasteur 2006;8(4):1132-40.
2006: Omar H Vandal; Michael H Gelb; Sabine Ehrt; Carl F Nathan
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
Infection and immunity 2006;74(3):1751-6.
2006: Shuangping Shi; Sabine Ehrt
Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
Infection and immunity 2006;74(1):56-63.
2005: Carl Nathan; Noel Y Calingasan; Jon Nezezon; Aihao Ding; M Scott Lucia; Krista La Perle; Michele Fuortes; Michael Lin; Sabine Ehrt; Nyoun Soo Kwon; Junyu Chen; Yoram Vodovotz; Khatuna Kipiani; M Flint Beal
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
The Journal of experimental medicine 2005;202(9):1163-9.
2005: Aihao Ding; Hongwei Yu; Jingxuan Yang; Shuangping Shi; Sabine Ehrt
Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88.
Immunology 2005;116(3):381-9.
2005: Shuangping Shi; Antje Blumenthal; Christopher Hickey; Sheetal Gandotra; David Levy; Sabine Ehrt
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3318-28.
2005: Rowan P Morris; Liem Nguyen; John Gatfield; Kevin C Visconti; Kien Nguyen; Dirk Schnappinger; Sabine Ehrt; Yang Liu; Leonid Heifets; Jean Pieters; Gary K Schoolnik; Charles J Thompson
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12200-5.
2005: Katherine B Hisert; Michael MacCoss; Michael Shiloh; K Heran Darwin; Shaneen Singh; Roger A Jones; Sabine Ehrt; Zhaoying Zhang; Barbara L Gaffney; Sheetal Gandotra; David W Holden; Diana Murray; Carl Nathan
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
Molecular microbiology 2005;56(5):1234-45.
2005: Sabine Ehrt; Xinzheng V Guo; Christopher Hickey; Marvin Ryou; Mercedes Monteleone; Lee W Riley; Dirk Schnappinger
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.
Nucleic acids research 2005;33(2):e21.
2003: K Heran Darwin; Sabine Ehrt; José-Carlos Gutierrez-Ramos; Nadine Weich; Carl F Nathan
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
Science (New York, N.Y.) 2003;302(5652):1963-6.
2003: Shuangping Shi; Carl Nathan; Dirk Schnappinger; Jorg Drenkow; Michele Fuortes; Ellen Block; Aihao Ding; Thomas Gingeras; Gary K Schoolnik; Shizuo Akira; Kiyoshi Takeda; Sabine Ehrt
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
The Journal of experimental medicine 2003;198(7):987-97.
2003: Dirk Schnappinger; Sabine Ehrt; Martin I Voskuil; Yang Liu; Joseph A Mangan; Irene M Monahan; Gregory M Dolganov; Brad Efron; Philip Butcher; Carl Nathan; Gary K Schoolnik
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.
The Journal of experimental medicine 2003;198(5):693-704.
2003: Sabine Ehrt; Dirk Schnappinger
Isolation of plasmids from E. coli by boiling lysis.
Methods in molecular biology (Clifton, N.J.) 2003;235():79-82.
2003: Sabine Ehrt; Dirk Schnappinger
Isolation of plasmids from E. coli by alkaline lysis.
Methods in molecular biology (Clifton, N.J.) 2003;235():75-8.
2001: I Kaps; Sabine Ehrt; S Seeber; Dirk Schnappinger; C Martin; Lee W Riley; Michael Niederweis
Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis.
Gene 2001;278(1-2):115-24.
2001: Sabine Ehrt; Dirk Schnappinger; Stefan Bekiranov; Jorg Drenkow; S Shi; Thomas Gingeras; Terry Gaasterland; Gary K Schoolnik; Carl Nathan
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.
The Journal of experimental medicine 2001;194(8):1123-40.
2000: Nancy A Buchmeier; AB Blanc-Potard; Sabine Ehrt; DL Piddington; Lee W Riley; E A Groisman
A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica.
Molecular microbiology 2000;35(6):1375-82.
1999: Michael Niederweis; Sabine Ehrt; Christian Heinz; U Klöcker; Stefanie Karosi; K M Swiderek; Lee W Riley; R Benz
Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis.
Molecular microbiology 1999;33(5):933-45.
1999: J Ruan; G St John; Sabine Ehrt; Lee W Riley; Carl Nathan
noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress.
Infection and immunity 1999;67(7):3276-83.
1997: Sabine Ehrt; Michael Shiloh; J Ruan; M Choi; S Gunzburg; Carl Nathan; Q Xie; Lee W Riley
A novel antioxidant gene from Mycobacterium tuberculosis.
The Journal of experimental medicine 1997;186(11):1885-96.
1997: F Schirmer; Sabine Ehrt; Wolfgang Hillen
Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.
Journal of bacteriology 1997;179(4):1329-36.
1995: Sabine Ehrt; F Schirmer; Wolfgang Hillen
Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250.
Molecular microbiology 1995;18(1):13-20.
1995: Walter Geissdörfer; S C Frosch; G Haspel; Sabine Ehrt; Wolfgang Hillen
Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1.
Microbiology (Reading, England) 1995;141 ( Pt 6)():1425-32.
1994: Sabine Ehrt; L N Ornston; Wolfgang Hillen
RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus.
Journal of bacteriology 1994;176(12):3493-9.
1994: Sabine Ehrt; Wolfgang Hillen
UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus.
FEMS microbiology letters 1994;117(2):137-42.